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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v25i1e43224</article-id>
      <article-id pub-id-type="pmid">37018013</article-id>
      <article-id pub-id-type="doi">10.2196/43224</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Lessons for Vietnam on the Use of Digital Technologies to Support Patient-Centered Care in Low- and Middle-Income Countries in the Asia-Pacific Region: Scoping Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Mavragani</surname>
            <given-names>Amaryllis</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Ding</surname>
            <given-names>Qinglan</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Adriaans</surname>
            <given-names>Danielle</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author">
          <name name-style="western">
            <surname>Kosowicz</surname>
            <given-names>Leona</given-names>
          </name>
          <degrees>BPsychSci, GCertHlthProm, MDiet</degrees>
          <xref rid="aff01" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-4780-8333</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Tran</surname>
            <given-names>Kham</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff01" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7159-5668</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Khanh</surname>
            <given-names>Toan Tran</given-names>
          </name>
          <degrees>MPH, MD, PhD</degrees>
          <xref rid="aff02" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-5902-749X</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Dang</surname>
            <given-names>Thu Ha</given-names>
          </name>
          <degrees>MIPH, MD</degrees>
          <xref rid="aff01" ref-type="aff">1</xref>
          <xref rid="aff03" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-9105-6920</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Pham</surname>
            <given-names>Van An</given-names>
          </name>
          <degrees>MD</degrees>
          <xref rid="aff04" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-2319-128X</ext-link>
        </contrib>
        <contrib id="contrib6" contrib-type="author">
          <name name-style="western">
            <surname>Ta Thi Kim</surname>
            <given-names>Hue</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff05" ref-type="aff">5</xref>
          <xref rid="aff06" ref-type="aff">6</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-1951-5656</ext-link>
        </contrib>
        <contrib id="contrib7" contrib-type="author">
          <name name-style="western">
            <surname>Thi Bach Duong</surname>
            <given-names>Hoang</given-names>
          </name>
          <degrees>MD</degrees>
          <xref rid="aff05" ref-type="aff">5</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7735-5294</ext-link>
        </contrib>
        <contrib id="contrib8" contrib-type="author">
          <name name-style="western">
            <surname>Nguyen</surname>
            <given-names>Tran Dong</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff05" ref-type="aff">5</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-9022-8265</ext-link>
        </contrib>
        <contrib id="contrib9" contrib-type="author">
          <name name-style="western">
            <surname>Phuong</surname>
            <given-names>Anh Tuyet</given-names>
          </name>
          <degrees>BSc</degrees>
          <xref rid="aff04" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-9666-1959</ext-link>
        </contrib>
        <contrib id="contrib10" contrib-type="author">
          <name name-style="western">
            <surname>Le</surname>
            <given-names>Trong Hieu</given-names>
          </name>
          <xref rid="aff07" ref-type="aff">7</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-6812-7778</ext-link>
        </contrib>
        <contrib id="contrib11" contrib-type="author">
          <name name-style="western">
            <surname>Ta</surname>
            <given-names>Van Anh</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff05" ref-type="aff">5</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-2924-1583</ext-link>
        </contrib>
        <contrib id="contrib12" contrib-type="author">
          <name name-style="western">
            <surname>Wickramasinghe</surname>
            <given-names>Nilmini</given-names>
          </name>
          <degrees>BSc, PhD</degrees>
          <xref rid="aff08" ref-type="aff">8</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-1314-8843</ext-link>
        </contrib>
        <contrib id="contrib13" contrib-type="author">
          <name name-style="western">
            <surname>Schofield</surname>
            <given-names>Penelope</given-names>
          </name>
          <degrees>BSc(Hons), PhD</degrees>
          <xref rid="aff03" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-9495-9543</ext-link>
        </contrib>
        <contrib id="contrib14" contrib-type="author">
          <name name-style="western">
            <surname>Zelcer</surname>
            <given-names>John</given-names>
          </name>
          <degrees>BMedSci(Hons), BS, MB</degrees>
          <xref rid="aff08" ref-type="aff">8</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7811-4855</ext-link>
        </contrib>
        <contrib id="contrib15" contrib-type="author">
          <name name-style="western">
            <surname>Pham Le</surname>
            <given-names>Tuan</given-names>
          </name>
          <degrees>MPHM, MD, PhD</degrees>
          <xref rid="aff02" ref-type="aff">2</xref>
          <xref rid="aff09" ref-type="aff">9</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7386-4585</ext-link>
        </contrib>
        <contrib id="contrib16" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Nguyen</surname>
            <given-names>Tuan Anh</given-names>
          </name>
          <degrees>BPharm, MPharm, PhD</degrees>
          <xref rid="aff01" ref-type="aff">1</xref>
          <address>
            <institution>Social Gerontology Division</institution>
            <institution>National Ageing Research Institute</institution>
            <addr-line>Gate 4, Building 8</addr-line>
            <addr-line>34-54 Poplar Road</addr-line>
            <addr-line>Parkville, 3052</addr-line>
            <country>Australia</country>
            <phone>61 3 8387 2305</phone>
            <email>t.nguyen@nari.edu.au</email>
          </address>
          <xref rid="aff03" ref-type="aff">3</xref>
          <xref rid="aff10" ref-type="aff">10</xref>
          <xref rid="aff11" ref-type="aff">11</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-9528-9278</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff01">
        <label>1</label>
        <institution>Social Gerontology Division</institution>
        <institution>National Ageing Research Institute</institution>
        <addr-line>Parkville</addr-line>
        <country>Australia</country>
      </aff>
      <aff id="aff02">
        <label>2</label>
        <institution>Department of Family Medicine</institution>
        <institution>Hanoi Medical University</institution>
        <addr-line>Hanoi</addr-line>
        <country>Vietnam</country>
      </aff>
      <aff id="aff03">
        <label>3</label>
        <institution>School of Health Sciences</institution>
        <institution>Swinburne University of Technology</institution>
        <addr-line>Melbourne</addr-line>
        <country>Australia</country>
      </aff>
      <aff id="aff04">
        <label>4</label>
        <institution>Hanoi Medical University</institution>
        <addr-line>Hanoi</addr-line>
        <country>Vietnam</country>
      </aff>
      <aff id="aff05">
        <label>5</label>
        <institution>New Horizon Palliative Care Company Limited</institution>
        <addr-line>Hanoi</addr-line>
        <country>Vietnam</country>
      </aff>
      <aff id="aff06">
        <label>6</label>
        <institution>Hanoi University of Science and Technology</institution>
        <addr-line>Hanoi</addr-line>
        <country>Vietnam</country>
      </aff>
      <aff id="aff07">
        <label>7</label>
        <institution>Hanoi University of Pharmacy</institution>
        <addr-line>Hanoi</addr-line>
        <country>Vietnam</country>
      </aff>
      <aff id="aff08">
        <label>8</label>
        <institution>Iverson Health Innovation Research Institute</institution>
        <institution>Swinburne University of Technology</institution>
        <addr-line>Melbourne</addr-line>
        <country>Australia</country>
      </aff>
      <aff id="aff09">
        <label>9</label>
        <institution>Military and Civil Medical Association of Vietnam</institution>
        <addr-line>Hanoi</addr-line>
        <country>Vietnam</country>
      </aff>
      <aff id="aff10">
        <label>10</label>
        <institution>UniSA Clinical and Health Sciences</institution>
        <institution>University of South Australia</institution>
        <addr-line>Adelaide</addr-line>
        <country>Australia</country>
      </aff>
      <aff id="aff11">
        <label>11</label>
        <institution>Health Strategy and Policy Institute</institution>
        <institution>Ministry of Health of Vietnam</institution>
        <addr-line>Hanoi</addr-line>
        <country>Vietnam</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Tuan Anh Nguyen <email>t.nguyen@nari.edu.au</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2023</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>5</day>
        <month>4</month>
        <year>2023</year>
      </pub-date>
      <volume>25</volume>
      <elocation-id>e43224</elocation-id>
      <history>
        <date date-type="received">
          <day>5</day>
          <month>10</month>
          <year>2022</year>
        </date>
        <date date-type="rev-request">
          <day>1</day>
          <month>11</month>
          <year>2022</year>
        </date>
        <date date-type="rev-recd">
          <day>11</day>
          <month>1</month>
          <year>2023</year>
        </date>
        <date date-type="accepted">
          <day>1</day>
          <month>2</month>
          <year>2023</year>
        </date>
      </history>
      <copyright-statement>©Leona Kosowicz, Kham Tran, Toan Tran Khanh, Thu Ha Dang, Van An Pham, Hue Ta Thi Kim, Hoang Thi Bach Duong, Tran Dong Nguyen, Anh Tuyet Phuong, Trong Hieu Le, Van Anh Ta, Nilmini Wickramasinghe, Penelope Schofield, John Zelcer, Tuan Pham Le, Tuan Anh Nguyen. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 05.04.2023.</copyright-statement>
      <copyright-year>2023</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://www.jmir.org/2023/1/e43224" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>A rapidly aging population, a shifting disease burden and the ongoing threat of infectious disease outbreaks pose major concerns for Vietnam’s health care system. Health disparities are evident in many parts of the country, especially in rural areas, and the population faces inequitable access to patient-centered health care. Vietnam must therefore explore and implement advanced solutions to the provision of patient-centered care, with a view to reducing pressures on the health care system simultaneously. The use of digital health technologies (DHTs) may be one of these solutions.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This study aimed to identify the application of DHTs to support the provision of patient-centered care in low- and middle-income countries in the Asia-Pacific region (APR) and to draw lessons for Vietnam.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>A scoping review was undertaken. Systematic searches of 7 databases were conducted in January 2022 to identify publications on DHTs and patient-centered care in the APR. Thematic analysis was conducted, and DHTs were classified using the National Institute for Health and Care Excellence evidence standards framework for DHTs (tiers A, B, and C). Reporting was in line with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>Of the 264 publications identified, 45 (17%) met the inclusion criteria. The majority of the DHTs were classified as tier C (15/33, 45%), followed by tier B (14/33, 42%) and tier A (4/33, 12%). At an individual level, DHTs increased accessibility of health care and health-related information, supported individuals in self-management, and led to improvements in clinical and quality-of-life outcomes. At a systems level, DHTs supported patient-centered outcomes by increasing efficiency, reducing strain on health care resources, and supporting patient-centered clinical practice. The most frequently reported enablers for the use of DHTs for patient-centered care included alignment of DHTs with users’ individual needs, ease of use, availability of direct support from health care professionals, provision of technical support as well as user education and training, appropriate governance of privacy and security, and cross-sectorial collaboration. Common barriers included low user literacy and digital literacy, limited user access to DHT infrastructure, and a lack of policies and protocols to guide the implementation and use of DHTs.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>The use of DHTs is a viable option to increase equitable access to quality, patient-centered care across Vietnam and simultaneously reduce pressures on the health care system. Vietnam can take advantage of the lessons learned by other low- and middle-income countries in the APR when developing a national road map to digital health transformation. Recommendations that Vietnamese policy makers may consider include emphasizing stakeholder engagement, strengthening digital literacy, supporting the improvement of DHT infrastructure, increasing cross-sectorial collaboration, strengthening governance of cybersecurity, and leading the way in DHT uptake.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>digital health technologies</kwd>
        <kwd>digital health</kwd>
        <kwd>eHealth</kwd>
        <kwd>mobile health</kwd>
        <kwd>mHealth</kwd>
        <kwd>patient-centered care</kwd>
        <kwd>Vietnam</kwd>
        <kwd>Asia-Pacific region</kwd>
        <kwd>digital</kwd>
        <kwd>disease</kwd>
        <kwd>technology</kwd>
        <kwd>database</kwd>
        <kwd>self-management</kwd>
        <kwd>clinical</kwd>
        <kwd>users</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>Vietnam’s health care landscape is changing. The country’s population is aging rapidly, with more than 1 in 5 Vietnamese citizens being predicted to be aged &#62;65 years by 2050 [<xref ref-type="bibr" rid="ref1">1</xref>]. It is forecast that Vietnam will transition from its current classification as an aging country, where 7% of the population is aged ≥65 years, to an aged country (ie, 14% of the population aged ≥65 years) in just 16 years [<xref ref-type="bibr" rid="ref1">1</xref>]. By contrast, nearby countries Thailand and Singapore will take 20 years and 22 years, respectively, to reach this point [<xref ref-type="bibr" rid="ref1">1</xref>]. This rapid aging is contributing to a shift in disease burden from communicable diseases to noncommunicable diseases (NCDs), that is, diseases that are not transmitted among persons but rather are the result of genetic, physiological, environmental, and behavioral factors [<xref ref-type="bibr" rid="ref2">2</xref>].</p>
        <p>In 2019, NCDs such as cardiovascular diseases, diabetes, and Alzheimer disease made up 8 of the top 10 causes of death in Vietnam for males and females across all age groups [<xref ref-type="bibr" rid="ref3">3</xref>]. Furthermore, global health estimates published by the World Health Organization in 2020 showed that the percentage of deaths caused by NCDs in Vietnam has increased from 73% to 81% in &#60;20 years [<xref ref-type="bibr" rid="ref3">3</xref>]. This presents a major problem for the country’s health care system. NCDs are typically chronic and multimorbid and therefore require coordinated, long-term care [<xref ref-type="bibr" rid="ref4">4</xref>]. Preventive measures for NCDs are also challenging, given the numerous risk factors associated with NCD onset [<xref ref-type="bibr" rid="ref4">4</xref>]. Prevention and management of NCDs consequently demands considerable resources from all areas of the health care system.</p>
        <p>By contrast, potential infectious disease outbreaks continue to threaten the health care system, and additional resources must remain on standby to cope with such eventualities. Vietnam’s existing health care system is not adequately resourced to meet these challenges. Health disparities are evident in many parts of the country, especially in rural areas, and the population faces inequitable access to quality, patient-centered health care [<xref ref-type="bibr" rid="ref5">5</xref>]. This raises concerns since patient-centered care is widely considered to be an effective approach to health care from the perspective of patients, families, and health care professionals, and may also reduce health care costs [<xref ref-type="bibr" rid="ref6">6</xref>-<xref ref-type="bibr" rid="ref8">8</xref>]. Vietnam must therefore explore and implement advanced solutions to the provision of patient-centered care, with a view to reducing pressures on the health care system simultaneously.</p>
        <p>The use of digital health technologies (DHTs) may be one of these solutions. Digital health refers to “the use of information and communications technologies in medicine and other health professions to manage illnesses and health risks and to promote wellness” [<xref ref-type="bibr" rid="ref9">9</xref>]. This may include but is not limited to the use of wearable devices, mobile health (mHealth), telehealth, health IT, and telemedicine. DHTs have been shown to be effective in supporting the management of both NCDs, such as diabetes and cardiovascular disease, and infectious diseases, such as COVID-19 [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref17">17</xref>]. Evidence suggests that DHTs may also support several dimensions of patient-centered care, such as health knowledge, self-efficacy, quality of life, and access to health care [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>].</p>
      </sec>
      <sec>
        <title>Objectives</title>
        <p>Although there is increasing research demonstrating the value of DHTs in general, the potential of DHTs to support patient-centered care in Vietnam has thus far been relatively unexplored. Many neighboring low- and middle-income countries (LMICs) in the Asia-Pacific region (APR) are already exploring or implementing DHTs within their health care systems. This offers Vietnam the opportunity to gain insight into the effective use of DHTs from countries that share economic and cultural similarities, and to apply these learnings when developing its own approach to the use of DHTs to support patient-centered care for patients with communicable diseases and those with NCDs. This paper therefore aimed to identify the application of DHTs to support the provision of patient-centered care in LMICs in the APR and to draw lessons for Vietnam.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Study Design</title>
        <p>A scoping review protocol was developed and registered on the Open Science Framework [<xref ref-type="bibr" rid="ref20">20</xref>]. The review was undertaken using the following established methodologies: (1) identifying the research questions; (2) identifying relevant studies; (3) study selection; (4) charting the data; and (5) collating, summarizing, and reporting the results [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref22">22</xref>]. Reporting was in line with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref> [<xref ref-type="bibr" rid="ref21">21</xref>-<xref ref-type="bibr" rid="ref23">23</xref>]).</p>
      </sec>
      <sec>
        <title>Review Questions</title>
        <p>The research questions guiding this review were as follows:</p>
        <list list-type="order">
          <list-item>
            <p>What types of DHTs are being used in LMICs in the APR?</p>
          </list-item>
          <list-item>
            <p>What patient-centered outcomes are associated with the use of DHTs?</p>
          </list-item>
          <list-item>
            <p>What are the enablers and barriers for the use of DHTs to support patient-centered care outcomes?</p>
          </list-item>
          <list-item>
            <p>What lessons can Vietnam learn when developing its own approach to the use of DHTs to support patient-centered care?</p>
          </list-item>
        </list>
      </sec>
      <sec>
        <title>Search Strategy</title>
        <p>Using search terms related to DHTs and patient-centered care, we conducted a comprehensive search in January 2022 in the following 8 electronic databases: MEDLINE, PubMed, Embase, EMCare, PsycInfo, Ovid Nursing Database, Web of Science, and Scopus. The search strategy for MEDLINE is presented in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>.</p>
        <p>Studies were considered eligible if they met the following criteria: (1) published in English or Vietnamese; (2) set in LMICs in the APR; (3) discussed communicable diseases or NCDs; and (4) discussed the application of DHTs to support patient-centered care with regard to patient-centered outcomes, barriers and enablers for the use of DHTs, and policy or practice outcomes. LMICs were defined according to the relevant 2022 World Bank country classifications: low-income economies (gross national income of ≤US $1085 per capita), lower middle-income economies (gross national income between US $1086 and US $4255 per capita), and upper middle-income economies (gross national income between US $4256 and US $13,205 per capita) [<xref ref-type="bibr" rid="ref24">24</xref>]. When selecting LMICs for inclusion, we applied the World Bank definition of the APR, which includes countries geographically neighboring Vietnam within East Asia and the Pacific [<xref ref-type="bibr" rid="ref24">24</xref>]. The search was not limited by publication date or type, although publications that did not present outcomes (eg, protocol papers) were excluded at the screening stage.</p>
        <p>The database searches were supplemented by manual searches and references as appropriate. Duplicates were removed using an EndNote library (Clarivate) [<xref ref-type="bibr" rid="ref25">25</xref>], and the remaining titles were imported into Covidence software (Veritas Health Innovation Ltd) for screening [<xref ref-type="bibr" rid="ref26">26</xref>].</p>
      </sec>
      <sec>
        <title>Study Selection</title>
        <p>Interrater reliability of the screening process was established using an initial selection of 5 publications that were independently screened at the title and abstract and full-text levels by 4 reviewers. Discrepancies in screening decisions were discussed and resolved by consensus before the final inclusion and exclusion criteria were agreed upon. The titles and abstracts of the remaining publications were then independently screened by 2 reviewers per publication before 2 reviewers completed a full-text review of each publication remaining thereafter. Conflicts were resolved through consensus.</p>
      </sec>
      <sec>
        <title>Data Extraction</title>
        <p>A data extraction form was developed to identify the key characteristics of each study as well as relevant information regarding the application of DHTs in the provision of patient-centered care. Seven reviewers independently extracted the data and resolved inconsistencies through discussion with 2 additional researchers. The variables included authors, publication year, country of origin, aims, settings, study design, methodology, type of DHT, reported outcomes, enablers, barriers, and policy and practice implications.</p>
      </sec>
      <sec>
        <title>Data Synthesis</title>
        <p>Thematic analysis was used to synthesize and report the findings, following the approach described by Braun and Clarke [<xref ref-type="bibr" rid="ref27">27</xref>]. This involved (1) familiarization with the data, (2) searching for themes, (3) reviewing the themes, (4) defining and naming the themes, and (5) producing the report.</p>
        <p>Outcomes were considered patient centered if they mapped against established definitions and determinants of patient-centered care, that is, health care that aligns with patients’ values, needs, and preferences, as well as increases patient autonomy and involvement in their care [<xref ref-type="bibr" rid="ref28">28</xref>]. Systems-level determinants of patient-centered care were also considered in addition to this definition, including factors related to system characteristics and structures and processes, as well as external policies, regulations, and resources [<xref ref-type="bibr" rid="ref29">29</xref>].</p>
        <p>Further to the thematic analysis, the full texts of the selected articles were analyzed to identify the types of DHTs used. The DHTs were then grouped according to classifications set out by the National Institute for Health and Care Excellence evidence standards framework for DHTs [<xref ref-type="bibr" rid="ref30">30</xref>]. This framework classifies DHTs by intended purpose and stratifies them into 3 tiers based on the potential risk to service users and to the system (tier A, tier B, and tier C). Tier A comprises DHTs intended to save costs, release staff time, or improve efficiency; tier B includes DHTs that help citizens and patients to manage their own health and wellness; and tier C comprises DHTs used for treating and diagnosing medical conditions or for guiding care choices [<xref ref-type="bibr" rid="ref30">30</xref>]. Each tier is further divided into subcategories that relate to the intended purpose of the DHT in question.</p>
      </sec>
      <sec>
        <title>Ethical Considerations</title>
        <p>Ethics approval was not required for this review paper.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Overview</title>
        <p>A total of 264 publications were identified through the database search, of which 45 (17%) were included in the final analysis (<xref rid="figure1" ref-type="fig">Figure 1</xref>). Of these 45 articles, 19 (42%) were quantitative studies (including n=3, 16%, randomized controlled trials), 7 (16%) were qualitative studies, 4 (9%) were mixed methods studies, 6 (13%) were technical reports, and 9 (20%) were review papers. The included articles were published between 2010 and 2021, with a majority published in 2020 (11/45, 24%) and 2021 (13/45, 29%). Most of the studies were conducted in India (14/45, 31%) and China (11/45,24%). Studies from Malaysia, Pakistan, Bangladesh, Indonesia, Nepal, Sri Lanka, Thailand, and Vietnam were also included. Of the 45 publications, 20 (44%) focused on NCDs (eg, diabetes, cardiovascular disease, and mental health conditions), 3 (7%) focused on communicable diseases (eg, COVID-19, tuberculosis, and acute diarrhea), and 5 (11%) encompassed both communicable diseases and NCDs, whereas the remaining publications (17/45, 38%) did not focus on a specific health condition or did not include this information. Of the 45 publications, 33 (73%) presented data on novel or specific DHTs, whereas the remaining studies (12/45, 27%) mapped the existing landscape of DHT-supported health care in specific countries or populations or provided evidence on enablers and barriers for DHT-supported health care. Detailed characteristics of the included studies are presented in <xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref> [<xref ref-type="bibr" rid="ref30">30</xref>-<xref ref-type="bibr" rid="ref75">75</xref>].</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) diagram of the study selection process.</p>
          </caption>
          <graphic xlink:href="jmir_v25i1e43224_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Classification of DHTs</title>
        <p>Among the 33 studies presenting novel or specific DHTs, the majority of the DHTs were classified as tier C (n=15, 45%), followed by tier B (n=14, 42%) and tier A (n=4, 12%). The DHTs identified were further classified by intended purpose (<xref ref-type="boxed-text" rid="box1">Textbox 1</xref> [<xref ref-type="bibr" rid="ref30">30</xref>]).</p>
        <boxed-text id="box1" position="float">
          <title>Summary of identified digital health technologies classified according to the National Institute for Health and Care Excellence evidence standards framework for digital health and care technologies.</title>
          <p>Tier A</p>
          <list list-type="bullet">
            <list-item>
              <p>System services: health information systems [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>] and mobile apps (medical document digitizer [<xref ref-type="bibr" rid="ref33">33</xref>] and patient appointment flow optimizer [<xref ref-type="bibr" rid="ref34">34</xref>])</p>
            </list-item>
          </list>
          <p>Tier B</p>
          <list list-type="bullet">
            <list-item>
              <p>Communicating about health and care: telemedicine and teleconsultation platforms (telephone, SMS text messaging, and video) [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref42">42</xref>] and appointment reminders [<xref ref-type="bibr" rid="ref36">36</xref>]</p>
            </list-item>
            <list-item>
              <p>Health and care diaries: mobile apps to track and record users’ health information for self-monitoring [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>]</p>
            </list-item>
            <list-item>
              <p>Promoting good health: internet-based health information [<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref46">46</xref>] and nonpersonalized health education via SMS text messaging [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref48">48</xref>]</p>
            </list-item>
          </list>
          <p>Tier C</p>
          <list list-type="bullet">
            <list-item>
              <p>Inform clinical management: mobile apps to allow remote monitoring of patient health information to provide personalized recommendations direct to users and inform clinical decision-making by health care professionals [<xref ref-type="bibr" rid="ref49">49</xref>-<xref ref-type="bibr" rid="ref59">59</xref>]</p>
            </list-item>
            <list-item>
              <p>Diagnose a condition: artificial intelligence–based self-diagnosis tool [<xref ref-type="bibr" rid="ref60">60</xref>]; mobile-based assessment tools [<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]; and software solution to allow mobile monitoring, assessment, and diagnosis [<xref ref-type="bibr" rid="ref63">63</xref>]</p>
            </list-item>
          </list>
        </boxed-text>
      </sec>
      <sec>
        <title>Patient-Centered Outcomes of DHTs</title>
        <p>In studies that evaluated the outcomes of DHT use, DHTs supported patient-centered outcomes at an individual level and a systems level.</p>
        <sec>
          <title>Individual-Level Outcomes</title>
          <p>At an individual level, DHTs increased accessibility of health care and health-related information, supported individuals to self-manage their health, and led to improvements in clinical and quality-of-life outcomes.</p>
          <sec>
            <title>Increased Accessibility</title>
            <p>Nedungadi et al [<xref ref-type="bibr" rid="ref58">58</xref>] designed and pilot-tested a self-monitoring system for managing well-being in rural areas of India. The device was shown to accurately monitor patient conditions, was easy to understand and valued by patients, and was able to be delivered at a low cost. Overall, the device contributed to filling a gap in access to health care and health-related information in rural Indian locations, where health care resources are scarce. An mHealth device for diabetes management and education developed in China showed similar results [<xref ref-type="bibr" rid="ref64">64</xref>]. The multimedia teaching platform within the device enabled users to easily access diabetes-related information, which was identified as an unmet need within the diabetes community. Secondary benefits of DHTs that increased accessibility included reduced travel times and reduced health care–related costs for both patients and their families [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]. The findings about increased accessibility and the associated benefits were further confirmed in qualitative studies that explored the benefits of mHealth and internet hospitals [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref66">66</xref>], as well as in review papers that addressed this topic [<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]. Overall, these DHTs promoted patient-centered outcomes by providing flexible health care options that met patients’ individual access needs.</p>
          </sec>
          <sec>
            <title>Improved Self-management</title>
            <p>DHTs were shown to support patients in self-monitoring and self-managing diabetes, COVID-19 infection, medication adherence, cardiovascular disease, and general health, increasing patients’ involvement in their own health care [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]; for example, Vitale et al [<xref ref-type="bibr" rid="ref53">53</xref>] developed a diabetes telemanagement system that was found to improve diabetes self-management in terms of frequency of blood glucose monitoring and frequency of insulin use. A COVID-19 symptom monitoring system developed by Lim et al [<xref ref-type="bibr" rid="ref50">50</xref>] supported patient decision-making with regard to symptom severity and actions required. Finally, Chew et al [<xref ref-type="bibr" rid="ref43">43</xref>] found evidence of improved medication adherence in people taking long-term medications who used a novel medication adherence app. A systematic review that explored the use of DHTs for self-management of cardiovascular disease reported that mHealth platforms can improve patient knowledge and confidence in self-management, increase active symptom monitoring and recording, and improve adherence to medications and appointments [<xref ref-type="bibr" rid="ref69">69</xref>].</p>
          </sec>
          <sec>
            <title>Improved Clinical and Quality-of-Life Outcomes</title>
            <p>In a cluster randomized controlled trial, Guo et al [<xref ref-type="bibr" rid="ref49">49</xref>] compared the use of an mHealth platform to usual care for the management of patients with atrial fibrillation. Patients in the intervention group had significantly lower rates of the composite outcome “ischemic stroke/systemic thromboembolism, death, and rehospitalization” (<italic>P</italic>&#60;.001) as well as consistently lower heart rates than those receiving usual care. In a cross-sectional study by Vitale et al [<xref ref-type="bibr" rid="ref53">53</xref>], patients with diabetes who received comprehensive care involving teleconsultations achieved better intermediate health outcomes than those receiving usual care (ie, significantly lower glycated hemoglobin: <italic>P</italic>=.003, cholesterol: <italic>P</italic>&#60;.001, and diastolic blood pressure: <italic>P</italic>=.02). Finally, a WeChat-based intervention implemented in China reduced depressive symptoms in participants who participated for a 3-month period [<xref ref-type="bibr" rid="ref55">55</xref>]. In contrast to these studies, a randomized controlled trial assessing the effectiveness of an SMS text messaging system for managing coronary heart disease reported no significant changes in any clinical outcomes measured [<xref ref-type="bibr" rid="ref48">48</xref>]. A single study specifically reported on quality-of-life outcomes related to DHT use. Gupta et al [<xref ref-type="bibr" rid="ref62">62</xref>] developed and implemented a telemedicine device for otology screening in rural India. Use of the device resulted in 265,615 referrals, and 45% (9443/20,986) of the referred patients who reported for and received treatment reported a “significant improvement in their quality of life.” Finally, in an evaluation of a mobile obstetrics monitoring platform, patients who received care using the platform almost unanimously reported an increased feeling of safety while being remotely monitored, which may be considered an aspect of quality of life [<xref ref-type="bibr" rid="ref63">63</xref>]. On the whole, these DHTs contributed to patient-centered outcomes by enabling access to health care that was effective and met patients’ clinical and psychosocial needs.</p>
          </sec>
        </sec>
        <sec>
          <title>Systems-Level Outcomes</title>
          <p>DHTs also supported systems-level determinants of patient-centered outcomes, including increased efficiency, reduced strain on health care resources, and support for patient-centered clinical practice.</p>
          <sec>
            <title>Increased Efficiency</title>
            <p>In some of the studies (6/45, 13%), DHTs reduced the amount of time clinical staff spent undertaking administrative tasks and thereby increased their availability for tasks that directly benefited patients. Ali et al [<xref ref-type="bibr" rid="ref33">33</xref>] trialed a mobile app for document digitization in hospitals and found a considerable time reduction in data aggregation and data transfer activities. Similarly, an eHealth system implemented at a primary health care center in India reduced the amount of time that staff spent generating reports [<xref ref-type="bibr" rid="ref31">31</xref>]. Another group of researchers developed a mobile app to improve patient flow during hospital appointments [<xref ref-type="bibr" rid="ref34">34</xref>]. The app was shown to reduce the number of times patients requested appointment information from hospital staff and to reduce the amount of time staff spent seeking appointment-related information and responding to patients. A qualitative study reported that mHealth allows staff to have timely access to patient records at the time of treatment [<xref ref-type="bibr" rid="ref66">66</xref>], and this finding was echoed in the evaluation of the mobile obstetrics monitoring platform described earlier, which allowed health care workers to remotely view patient records [<xref ref-type="bibr" rid="ref63">63</xref>]. A narrative review paper also highlighted the role of DHTs in increasing operational efficiencies [<xref ref-type="bibr" rid="ref67">67</xref>].</p>
          </sec>
          <sec>
            <title>Reduced Strain on Health Care Resources</title>
            <p>DHTs supported reducing strain on health care resources in 3 ways. First, DHTs were shown to facilitate remote monitoring of patients’ health status [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]; for example, the COVID-19 symptom monitoring system designed by Lim et al [<xref ref-type="bibr" rid="ref50">50</xref>] monitored patient stability, connected health care professionals and patients via teleconsultations, and alerted patients and health care professionals to changes in, and worsening of, symptoms. Most of the patients were thereby enabled to recover at home rather than needing to be hospitalized, reducing unnecessary use of health care resources and simultaneously supporting patient preference. Reductions in emergency conditions and resultant hospitalizations also emerged as benefits of remote monitoring in several other publications [<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]. Second, DHTs reduced the need for referral to other health care professionals or diagnostic services. According to a narrative review, the use of teleconsultations coupled with services such as teleradiology and telepathology may enable patients to receive advice and diagnoses in a shorter time period and without the need for referral to specialists, thereby freeing up specialist availability while also providing patients with faster access to the care they need [<xref ref-type="bibr" rid="ref65">65</xref>]. Third and last, DHTs enabled patients to be triaged to a care mode that best suited their needs and preferences [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref70">70</xref>]. As in the case of remote monitoring, this enabled some patients to receive remote care rather than receiving face-to-face care and thereby contributed to both meeting patient preferences and the conservation of clinic and hospital resources.</p>
          </sec>
          <sec>
            <title>Support for Patient-Centered Clinical Practice</title>
            <p>In 9% (4/45) of the studies, DHTs were reported to support health care staff in efficient decision-making, accurate assessment, and timely diagnosis [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref63">63</xref>]. This enabled health care staff to provide care that was closely aligned with patients’ clinical needs, whereby patients received the right care at the right time. DHTs also improved continuity of care (eg, by reducing repeated patient and health care provider interactions) [<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref66">66</xref>] and facilitated multidisciplinary teamwork by connecting different health care professionals remotely [<xref ref-type="bibr" rid="ref63">63</xref>]. For patients, this translated into a more seamless health care journey and enabled them to receive holistic health care from a number of disciplines when required.</p>
          </sec>
        </sec>
      </sec>
      <sec>
        <title>Enablers and Barriers for the Use of DHTs for Patient-Centered Care</title>
        <p>Enablers and barriers for the use of DHTs for patient-centered care emerged at the level of the device or platform, the user, and the broader environment (<xref ref-type="table" rid="table1">Table 1</xref>). At the device or platform level (ie, characteristics and design of DHTs), the most commonly reported enablers related to the ability of DHTs to meet users’ individual needs, such as those that integrated easily with users’ lives or workflows [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref69">69</xref>] and those that were adapted to local languages, cultures, and literacy levels [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref71">71</xref>]. Co-design methodology was commonly suggested as an enabler to developing DHTs that aligned with users’ individual needs [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]. Incorporation of direct support from health care professionals (eg, teleconsultations) was also recommended [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref69">69</xref>], as was ensuring that users found DHTs easy to use [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref72">72</xref>]. Although no barriers to patient-centered outcomes pertaining to the characteristics or design of DHTs were specifically reported in these studies, each of the enablers, if considered in reverse, could be considered barriers (eg, DHTs that are not adapted to local languages).</p>
        <p>Regarding the user level, the availability of technical support and user education and training with regard to DHTs was the most commonly reported enabler [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>], whereas low literacy and technical literacy emerged as a user-level barrier in several of the publications (9/45, 20%) [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>].</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Enablers and barriers for the use of digital health technologies (DHTs) for patient-centered care.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="120"/>
            <col width="470"/>
            <col width="410"/>
            <thead>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Enablers</td>
                <td>Barriers</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Device or platform level</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Uses triaging to assess users’ suitability for DHT-supported vs face-to-face care [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref64">64</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>DHT is individualized to users’ needs [<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref71">71</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Platform type suits the needs of the user [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Allows personalized monitoring and self-management [<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>DHT use integrates with users’ daily lives and workflows [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Adapted to local language, culture, context, and literacy levels [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref71">71</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Provides accurate and clear information [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref60">60</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Incorporates direct support from health care professionals [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Content is adaptable to changing clinical evidence [<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref54">54</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Enables multidisciplinary collaboration [<xref ref-type="bibr" rid="ref63">63</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Uses centralized, sharable data [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Validated for use in the proposed context [<xref ref-type="bibr" rid="ref39">39</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Co-designed in collaboration with end users (eg, considers their needs and concerns) [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>DHTs that are easy and fun to use [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref72">72</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Adequate device performance (eg, battery life and processing speed) [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Data stored, shared, and used securely [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>None specifically reported</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>User level</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Adequate provider-patient relationship building [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Technical support, training, or education available for users [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>User willingness to adapt and positive attitude toward change [<xref ref-type="bibr" rid="ref68">68</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Behavioral factors such as perception of DHTs as trustworthy [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref68">68</xref>], useful [<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref72">72</xref>], and able to meet users’ needs and health goals [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref72">72</xref>]</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Low literacy and technology literacy [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>User concerns around the following aspects:</p>
                      <list list-type="bullet">
                        <list-item>
                          <p>Privacy and security [<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref67">67</xref>-<xref ref-type="bibr" rid="ref69">69</xref>]</p>
                        </list-item>
                        <list-item>
                          <p>Financial risks [<xref ref-type="bibr" rid="ref51">51</xref>]</p>
                        </list-item>
                        <list-item>
                          <p>Self-ability to use DHTs [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]</p>
                        </list-item>
                        <list-item>
                          <p>Effort, time consumption, and workload disruption [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref72">72</xref>]</p>
                        </list-item>
                        <list-item>
                          <p>Credibility and reliability of content [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]</p>
                        </list-item>
                      </list>
                    </list-item>
                  </list>
                  <list list-type="bullet">
                    <list-item>
                      <p>Possible inaccuracy of user data entry or reporting [<xref ref-type="bibr" rid="ref66">66</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Difficulty developing patient-provider rapport via DHTs [<xref ref-type="bibr" rid="ref38">38</xref>]</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Environmental level</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Decreasing prices of electronic devices in general [<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref75">75</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Improved mobile technology infrastructure [<xref ref-type="bibr" rid="ref75">75</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Community “hubs” that enable wider access to DHTs [<xref ref-type="bibr" rid="ref65">65</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Adequate DHT infrastructure (eg, in rural areas) [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref75">75</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Positive promotion of DHTs to users [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Governance that ensures security, privacy, and integrity of DHTs [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref65">65</xref>-<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref74">74</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Inclusion of DHT-based care in health insurance [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref71">71</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Cross-sectorial collaboration on development, implementation, and promotion of DHTs [<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref71">71</xref>]</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Limited user access to mobile phones, computers, internet, and reliable electricity in some locations [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>High cost of implementing or accessing some DHTs [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref75">75</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Environmental factors that limit users’ ability to independently implement lifestyle recommendations (eg, lack of public exercise spaces) [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref47">47</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Lack of policies and protocols to guide DHT implementation and use [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]</p>
                    </list-item>
                  </list>
                </td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <p>Finally, at a broader environmental level, governance that ensures security, privacy, and integrity of DHTs [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref65">65</xref>-<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref74">74</xref>] as well as cross-sectorial collaboration between and within government and nongovernment sectors on development, implementation, and promotion of DHTs [<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref71">71</xref>] were the most frequently reported enablers. Limited user access to DHT infrastructure (especially among populations residing in rural areas and those with low socioeconomic status) [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref65">65</xref>] and a lack of policies and protocols to guide the implementation and use of DHTs [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref68">68</xref>] emerged as common barriers at the environmental level.</p>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>This scoping review is the first to bring together evidence regarding the use of DHTs to support patient-centered care in LMICs in the APR, contributing to an increase in the knowledge base about the value of DHTs in non-Western countries. The findings suggest that many LMICs in the APR are successfully using DHTs to support the equitable provision of patient-centered care and simultaneously reduce pressures on their health care systems. To optimize success when developing its own approach to the use of DHTs to address the country’s specific health care challenges, Vietnam should take advantage of the lessons learned by these neighboring countries. In line with the findings of previous studies, DHTs were shown to be a viable option for the management of NCDs such as diabetes, cardiovascular disease, and depression in LMICs in the APR, which is encouraging, given the rise of NCDs in Vietnam. Evidence from a study on remote monitoring of patients with COVID-19 infection also demonstrated the potential of DHTs to conserve health care resources in the face of communicable disease outbreaks [<xref ref-type="bibr" rid="ref50">50</xref>]. Perhaps most promisingly, DHTs were able to increase access to health-related information and health care services in rural and low-income areas. This suggests that DHTs may go some way toward addressing the health disparities that persist in Vietnam.</p>
        <p>However, both the development and implementation of DHTs to support patient-centered care were not without challenges. Although several enablers for the use of DHTs were identified, so too were many barriers at the user and environmental levels. These barriers need to be considered and accounted for when planning for widespread use of DHTs. It is also important to note that, although no barriers pertaining to the individual characteristics or design of DHTs were specifically reported, a lack of evidence regarding device- and platform-level barriers in the included studies does not indicate the absence of barriers at this level. Each of the enablers reported at the device and platform levels may also act as a barrier to patient-centered outcomes if not fulfilled. The same is true of enablers at the user and environmental levels. Therefore, policy makers should take a holistic view with regard to enablers and barriers and give equal weight to both when planning for DHT use. There are several recommendations that Vietnamese policy makers may consider.</p>
        <p>First, it is important to emphasize stakeholder engagement. According to our findings, DHTs that strongly align with the needs of end users reflect patient-centered principles and are likely to enable patient-centered outcomes. Therefore, it is crucial to engage with end users at all stages of DHT development and implementation to understand and meet their needs. This could be achieved by adopting a co-design approach. Co-design has been well established as a methodology for the development and ongoing improvement of health care services [<xref ref-type="bibr" rid="ref76">76</xref>]. It is defined as “collective creativity as it is applied across the whole span of a design process” [<xref ref-type="bibr" rid="ref77">77</xref>], which in this context refers to the involvement of a diverse range of stakeholders (ie, patients and their carers, health care professionals, researchers, and technology designers) throughout the development and implementation of DHTs. Several studies identified in this review used elements of co-design to determine the feasibility, acceptability, and usability of DHTs, and this approach was strongly recommended to increase the likelihood of patient-centered outcomes [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref59">59</xref>].</p>
        <p>Second, measures are needed to strengthen digital literacy among the Vietnamese population. According to the <italic>Global Competitiveness Index 4.0 2019 Rankings</italic>, which measure digital skills among the active population on a scale ranging from 1 to 7, Vietnam achieved a value of 3.8 [<xref ref-type="bibr" rid="ref78">78</xref>]. Although Vietnam is ranked fourth in a list of 8 Association of Southeast Asian Nations member states in terms of digital literacy [<xref ref-type="bibr" rid="ref79">79</xref>], it comes in 97th when compared with global estimates among 141 countries [<xref ref-type="bibr" rid="ref78">78</xref>]. Our findings demonstrated that low digital literacy is a key barrier to the uptake of DHTs for both patients and health care staff and as such may restrict access to patient-centered health care if not addressed. Digital literacy education is therefore required. A multimodal approach is needed, including school-based education, community education and adult learning, and workforce training and development. This would enable the Vietnamese population to develop strong foundations in digital literacy, as well as improve their digital literacy in later life. For guidance, Vietnam may look to the World Health Organization’s Global Strategy on Digital Health 2020-2025, which includes improved digital literacy in its strategic objectives [<xref ref-type="bibr" rid="ref80">80</xref>]. Our findings suggest that, even with adequate digital literacy, users value the availability of technical support and training for the use of specific DHTs. As such, DHT developers should consider this an essential component of their product.</p>
        <p>Third, support is needed for the improvement of DHT infrastructure. Population-wide access to affordable and reliable mobile devices, computers, internet and mobile networks, and electricity is essential for the use of DHTs according to the studies included in this review. Promisingly, the Vietnamese government has already committed to improving the nation’s digital infrastructure in its National Digital Transformation Program 2025-2030 [<xref ref-type="bibr" rid="ref81">81</xref>]. Targets include improvements to internet and mobile networks throughout the country, as well as the establishment of a telemedicine unit in 100% of the health care services. However, no measures or targets relate specifically to improving digital infrastructure in rural and low-income regions of Vietnam. Our findings indicate that these regions may require additional support to achieve equitable access to DHTs, using measures such as subsidized access to these technologies and inclusion of DHT-supported care in medical insurance plans [<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref71">71</xref>].</p>
        <p>Fourth, our findings highlight cross-sectorial collaboration on development, implementation, and promotion of DHTs as a key enabler for the use of DHTs to support patient-centered care. This aligns with findings from previous studies [<xref ref-type="bibr" rid="ref82">82</xref>,<xref ref-type="bibr" rid="ref83">83</xref>]. A coordinated, whole-system approach is needed to overcome the complexities and costs of implementing a comprehensive DHT system in Vietnam. This should involve collaboration between the ministry of health and other relevant government departments (ie, the ministry of science and technology and the ministry of information and communications), as well as local and international collaboration with health care providers, the private sector, researchers, technology developers, social entrepreneurs, and consumers [<xref ref-type="bibr" rid="ref67">67</xref>].</p>
        <p>Fifth, efforts must be made to strengthen the governance of health-related cybersecurity<bold><italic>.</italic></bold> The use of DHTs to record, store, and share health data increases the risk of privacy and security breaches [<xref ref-type="bibr" rid="ref84">84</xref>]. Data security is a key concern for end users according to this review and is likely to affect the uptake of DHTs. Adequate governance of DHTs with regard to cybersecurity is therefore needed to protect users’ information and to promote trust in the security and integrity of DHTs. Currently, data protection laws in Vietnam are fragmented. Cyberinformation security (ie, information exchanged in a telecommunications or computer network environment) is governed by Law No. 86/2015/QH13 (2015), whereas cybersecurity falls under Law No. 24/2018/QH14 (2018) [<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]. Although the law on cybersecurity recognizes <italic>health</italic> as an information system critical for national security, no detail on specific regulations or protections is provided with regard to health data in either of these laws. To promote trust, specific regulations concerning the protection of health data that are recorded, stored, and shared using DHTs are required. Resources must also be dedicated to enforcing the resultant regulations.</p>
        <p>Sixth and last, we found that a lack of policies and protocols to guide DHT implementation and use was a common barrier to the application of DHTs to support patient-centered care. Conversely, clear positions and policies at the government level promoted confidence in DHTs within the broader community and guided their appropriate use. The Vietnamese government therefore has the opportunity to lead the way in DHT uptake in the nation. Developing and publishing guidelines on the use of DHTs, including patient-centered DHT-supported care, would set the standard for quality use of DHTs and inform best practice for both health care professionals and technology developers. Vietnam could look to neighboring countries as an example. In India, the ministry of health and family welfare collaborated with the Medical Council of India to develop telemedicine guidelines [<xref ref-type="bibr" rid="ref38">38</xref>]. These guidelines supported the health care system to adapt quickly to telehealth during the COVID-19 pandemic while still maintaining a consistent standard of patient-centered care. Without such guidelines, many disparate approaches to telehealth could have resulted, and the quality of DHT-supported care would have been likely to vary.</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>This study may have been limited in its ability to provide a comprehensive overview of the use of DHTs to support patient-centered outcomes in all LMICs in the APR. Although the scoping review methodology allowed for a broad search, it was necessary to limit the search to papers published in English and Vietnamese. This may have excluded publications available in other regional languages.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>The use of DHTs is a viable option to increase equitable access to quality, patient-centered care across Vietnam and simultaneously reduce pressures faced by the health care system owing in part to a rapidly aging population and an increase in NCDs. Vietnam can take advantage of the lessons learned by other LMICs in the APR when developing its own approach to the use of DHTs. The following strategies are recommended: (1) emphasize stakeholder engagement, (2) strengthen digital literacy, (3) support the improvement of DHT infrastructure, (4) increase cross-sectorial collaboration, (5) strengthen governance of cybersecurity, and (6) lead the way in DHT uptake. Mapping existing DHT applications in Vietnam and evaluating the effectiveness of these DHT applications should be considered for future research. Investigations of the needs, preferences, and experiences of key Vietnamese stakeholders (eg, patients and their carers, health care workers and providers, and DHT developers) related to DHTs are also needed. This information would support the Vietnamese government to develop a national road map for DHTs and align the approach to DHT use most closely with local needs.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist.</p>
        <media xlink:href="jmir_v25i1e43224_app1.pdf" xlink:title="PDF File  (Adobe PDF File), 498 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Search strategy and results for MEDLINE.</p>
        <media xlink:href="jmir_v25i1e43224_app2.docx" xlink:title="DOCX File , 16 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Characteristics of the included studies.</p>
        <media xlink:href="jmir_v25i1e43224_app3.docx" xlink:title="DOCX File , 54 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">APR</term>
          <def>
            <p>Asia-Pacific region</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">DHT</term>
          <def>
            <p>digital health technology</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">LMICs</term>
          <def>
            <p>low- and middle-income countries</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">mHealth</term>
          <def>
            <p>mobile health</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">NCD</term>
          <def>
            <p>noncommunicable disease</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">PRISMA-ScR</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>TAN was supported by a National Health and Medical Research Council (NHMRC)–Australian Research Council Dementia Research Development Fellowship (APP1103860) and an NHMRC–National Foundation for Science and Technology Development of Vietnam international collaborative research grant (APP1154644) and is currently supported by an NHMRC–e-ASIA grant (APP2001548).</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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