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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v25i1e43116</article-id>
      <article-id pub-id-type="pmid">36853749</article-id>
      <article-id pub-id-type="doi">10.2196/43116</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Exposure to Pornography and Adolescent Sexual Behavior: Systematic Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Kukafka</surname>
            <given-names>Rita</given-names>
          </name>
        </contrib>
        <contrib contrib-type="editor">
          <name>
            <surname>Eysenbach</surname>
            <given-names>Gunther</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Price</surname>
            <given-names>Carrie</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Pathmendra</surname>
            <given-names>Pranujan</given-names>
          </name>
          <degrees>BSc/BAdvSt (Hons)</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Specialty of Child and Adolescent Health</institution>
            <institution>Faculty of Medicine and Health</institution>
            <institution>The University of Sydney</institution>
            <addr-line>Corner Hawkesbury Road and Hainsworth Street</addr-line>
            <addr-line>Westmead, 2145</addr-line>
            <country>Australia</country>
            <fax>61 298453489</fax>
            <phone>61 298450000</phone>
            <email>ppat9224@uni.sydney.edu.au</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-9425-6271</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Raggatt</surname>
            <given-names>Michelle</given-names>
          </name>
          <degrees>BBiomedSc(Hons)</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-3186-8959</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Lim</surname>
            <given-names>Megan SC</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <xref rid="aff3" ref-type="aff">3</xref>
          <xref rid="aff4" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-3136-6761</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Marino</surname>
            <given-names>Jennifer L</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff4" ref-type="aff">4</xref>
          <xref rid="aff5" ref-type="aff">5</xref>
          <xref rid="aff6" ref-type="aff">6</xref>
          <xref rid="aff7" ref-type="aff">7</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-6742-1940</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Skinner</surname>
            <given-names>S Rachel</given-names>
          </name>
          <degrees>PhD, MBBS</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff8" ref-type="aff">8</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-1970-9792</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Specialty of Child and Adolescent Health</institution>
        <institution>Faculty of Medicine and Health</institution>
        <institution>The University of Sydney</institution>
        <addr-line>Westmead</addr-line>
        <country>Australia</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Burnet Institute</institution>
        <addr-line>Melbourne</addr-line>
        <country>Australia</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>School of Public Health and Preventative Medicine</institution>
        <institution>Monash University</institution>
        <addr-line>Melbourne</addr-line>
        <country>Australia</country>
      </aff>
      <aff id="aff4">
        <label>4</label>
        <institution>Melbourne School of Population and Global Health</institution>
        <institution>University of Melbourne</institution>
        <addr-line>Melbourne</addr-line>
        <country>Australia</country>
      </aff>
      <aff id="aff5">
        <label>5</label>
        <institution>Department of Obstetrics and Gynaecology</institution>
        <institution>Royal Women’s Hospital and University of Melbourne</institution>
        <addr-line>Parkville</addr-line>
        <country>Australia</country>
      </aff>
      <aff id="aff6">
        <label>6</label>
        <institution>Centre for Adolescent Health</institution>
        <institution>Murdoch Children’s Research Institute</institution>
        <addr-line>Parkville</addr-line>
        <country>Australia</country>
      </aff>
      <aff id="aff7">
        <label>7</label>
        <institution>Department of Paediatrics</institution>
        <institution>University of Melbourne</institution>
        <addr-line>Parkville</addr-line>
        <country>Australia</country>
      </aff>
      <aff id="aff8">
        <label>8</label>
        <institution>Kids Research, Sydney Children’s Hospitals Network</institution>
        <addr-line>Westmead</addr-line>
        <country>Australia</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Pranujan Pathmendra <email>ppat9224@uni.sydney.edu.au</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2023</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>28</day>
        <month>2</month>
        <year>2023</year>
      </pub-date>
      <volume>25</volume>
      <elocation-id>e43116</elocation-id>
      <history>
        <date date-type="received">
          <day>30</day>
          <month>9</month>
          <year>2022</year>
        </date>
        <date date-type="rev-request">
          <day>1</day>
          <month>11</month>
          <year>2022</year>
        </date>
        <date date-type="rev-recd">
          <day>29</day>
          <month>1</month>
          <year>2023</year>
        </date>
        <date date-type="accepted">
          <day>31</day>
          <month>1</month>
          <year>2023</year>
        </date>
      </history>
      <copyright-statement>©Pranujan Pathmendra, Michelle Raggatt, Megan SC Lim, Jennifer L Marino, S Rachel Skinner. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 28.02.2023.</copyright-statement>
      <copyright-year>2023</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://www.jmir.org/2023/1/e43116" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>Formative experiences in adolescence lay the foundation for healthy and pleasurable romantic and sexual relationships. Exposure to pornography may affect these experiences.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>We aimed to synthesize evidence published in the past decade on the relationship between exposure to pornography and sexual behavior (earlier age of first sex [&#60;16 years], condomless sex, past-year multiple partners [&#62;1], lifetime multiple partners [&#62;1], group sex, sexual aggression including forced sex, paid sex, teenage pregnancy, and history of sexually transmitted infection) in adolescents aged between 10 and 19 years.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>We identified 19 eligible studies by searching MEDLINE, PsycINFO, Cochrane, CINAHL, Embase, and Web of Science databases from January 2010 to November 2022.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>Out of 8 studies that assessed earlier age of first sex, 5 studies, including 1 longitudinal study, found a statistically significant association with exposure to pornography. Given that most studies were cross-sectional or had substantial limitations, causal inference could not be made. Also, exposure to pornography was not measured consistently. The evidence was conflicting or insufficient to draw any conclusions regarding other outcomes.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>More quantitative research is needed to elucidate the association between pornography exposure and sexual behavior, and sex education should adopt evidence-based approaches to minimize the potential harms from pornography.</p>
        </sec>
        <sec sec-type="trial registration">
          <title>Trial Registration</title>
          <p>PROSPERO International Prospective Register of Systematic Reviews CRD42021227390; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=227390</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>adolescence</kwd>
        <kwd>teenager</kwd>
        <kwd>sexual debut</kwd>
        <kwd>sexual behavior</kwd>
        <kwd>risky behavior</kwd>
        <kwd>pornography use</kwd>
        <kwd>digital media</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <p>Adolescence (ages 10-19 years) is a period of marked physical, cognitive, and psychosocial development [<xref ref-type="bibr" rid="ref1">1</xref>]. Curiosity and experimentation are common in the context of adolescent psychosexual development [<xref ref-type="bibr" rid="ref2">2</xref>], and adolescents who experience healthy relationships are more likely to have healthy relationships in their young adulthood [<xref ref-type="bibr" rid="ref3">3</xref>]. However, some sexual behaviors can increase the risk of sexually transmitted infections or unplanned pregnancy [<xref ref-type="bibr" rid="ref4">4</xref>]. Examples include earlier age of first sexual experience, condomless sex, or sex with multiple partners [<xref ref-type="bibr" rid="ref5">5</xref>]. Studies have also suggested that teen dating violence, including sexual aggression in adolescence, is linked to substance abuse problems, depression, and psychosis [<xref ref-type="bibr" rid="ref6">6</xref>]. Hence, studying the factors associated with these types of sexual behaviors in adolescence is crucial for understanding how to best support the healthy development of adolescents.</p>
      <p>In adults and older populations of young adults, quantitative studies have demonstrated associations between pornography exposure and behaviors such as sex with multiple partners and condomless sex and sex during intoxication [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref8">8</xref>]. Qualitative and mixed methods studies have also supported this association [<xref ref-type="bibr" rid="ref9">9</xref>-<xref ref-type="bibr" rid="ref12">12</xref>]. In the era of en masse digitalization and the widespread use of smartphones and other readily accessible digital media, exposure to pornography has become ubiquitous [<xref ref-type="bibr" rid="ref13">13</xref>]. Studies in Australia [<xref ref-type="bibr" rid="ref8">8</xref>] and the United States [<xref ref-type="bibr" rid="ref14">14</xref>] suggest that adolescents are exposed to pornography by the age of 13 years on average for males and 17 years for females despite laws prohibiting showing or supplying pornography for those aged &#60;18 years [<xref ref-type="bibr" rid="ref15">15</xref>-<xref ref-type="bibr" rid="ref18">18</xref>]. This raises concerns as to whether exposure to pornography influences sexual behavior during adolescence.</p>
      <p>As noted in a review by Peter and Valkenburg [<xref ref-type="bibr" rid="ref19">19</xref>] in 2016, there has been increasing empirical research on this subject area. However, whether pornography exposure is causally associated with sexual behavior in adolescence remains contentious [<xref ref-type="bibr" rid="ref19">19</xref>-<xref ref-type="bibr" rid="ref23">23</xref>]. It has been argued that adolescents are aware of the shortcomings and artificiality of pornography, hence the impact on sexual behavior is limited [<xref ref-type="bibr" rid="ref9">9</xref>], whereas others have argued the converse, claiming that pornography exposure is a strong predictor of earlier age of first sex, sexual aggression, and other sexual behaviors [<xref ref-type="bibr" rid="ref24">24</xref>], as well as a platform upon which adolescents develop their sexual identities and relationships [<xref ref-type="bibr" rid="ref25">25</xref>]. Previous systematic reviews of the evidence focused on college students [<xref ref-type="bibr" rid="ref24">24</xref>] and adolescents diagnosed with porn addiction [<xref ref-type="bibr" rid="ref26">26</xref>] and did not consider some potentially important sexual behaviors such as paid sex [<xref ref-type="bibr" rid="ref19">19</xref>]. We sought to update the Peter and Valkenburg [<xref ref-type="bibr" rid="ref19">19</xref>] review in the era of ubiquitous smartphones by systematically reviewing the empirical literature measuring exposure to pornography and its associations with sexual behaviors in adolescents in the general population.</p>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Overview</title>
        <p>We conducted a systematic review of quantitative studies that examined the associations between exposure to pornography and sexual behaviors in adolescents aged between 10 and 19 years. We followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines (<xref rid="figure1" ref-type="fig">Figure 1</xref> and <xref ref-type="supplementary-material" rid="app1">Multimedia Appendices 1</xref> and <xref ref-type="supplementary-material" rid="app2">2</xref>) [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref28">28</xref>]. This systematic review was registered with the International Prospective Register of Systematic Reviews (PROSPERO registration number: CRD42021227390).</p>
        <p>We searched 6 databases: CINAHL (via EBSCOhost), Cochrane Reviews (via Ovid, see <xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref> for specific Cochrane databases searched), Embase (via Ovid), MEDLINE (via Ovid), PsycINFO (via Ovid), and Web of Science (all databases: Web of Science, Current Contents Connect, BIOSIS Previews, CAB Abstracts, and MEDLINE). The search strategy, developed in MEDLINE and later adapted to other databases, used controlled vocabulary and free-text terms that related to the 2 key concepts of adolescents and pornography (<xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref>) as appropriate for each database. The search strategy, including adaptations, was developed by an experienced specialist research librarian. By design, search terms did not include “preteen*” and “prepubert*” because these terms were considered less likely to yield studies about young users of pornography than about child pornography (see <italic>Inclusion and Exclusion Criteria</italic>). Similarly, the names of apps were not included as search terms, because the apps are used not only for pornography by our definition (in subsequent section) but also for interactive sexual experiences. The searches were limited to peer-reviewed papers published from January 1, 2010, to November 30, 2022, to update a previous review article [<xref ref-type="bibr" rid="ref19">19</xref>]. Other studies that were found to be independent of our search strategy were identified through citation searches.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart of systematic literature search on adolescent (aged 10-19 years) use of pornography.</p>
          </caption>
          <graphic xlink:href="jmir_v25i1e43116_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Inclusion and Exclusion Criteria</title>
        <p>To be considered eligible, studies must have reported quantitative empirical findings on the association between exposure to pornography and sexual behavior outcomes (<xref ref-type="table" rid="table1">Table 1</xref>). Qualitative studies and systematic reviews were excluded from analysis. For this review, exposure to pornography was defined as a participant’s report of any contact with sexually explicit or erotic media (pornography), with the intent of sexual arousal [<xref ref-type="bibr" rid="ref29">29</xref>]. We included studies that did not define the exposure but used synonymous terms such as “sexually explicit material,” “adult or X-rated material,” or “pornography” without defining it in the methods. We excluded studies on child pornography, that is, sexually explicit or erotic material portraying individuals aged &#60;18 years.</p>
        <p>Sexual behavioral outcomes included those with established associations with adverse health and social outcomes (<xref ref-type="table" rid="table1">Table 1</xref>). Studies describing sexual aggression were limited to those that measured forced or coercive penetrative sex, excluding those that reported only on forced or coercive kissing and touching or used only the term “sexual acts” without further specification. Composite indices of sexual behaviors were excluded, as the association could not be clearly mapped to a specific behavior. The included studies were limited to those with adolescent participants (aged 10-19 years, inclusive), in which the age range was not provided, and the reported mean or median age was within this range. Included studies were those from a general population sample, and studies with clinical or specific population groups (eg, juvenile detention) were excluded. There was no restriction on the ethnicity of the participants or the study country. Multiple studies that analyzed the same cohort were considered together if they reported different associations.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>List of sexual behavior outcomes considered eligible for present systematic review.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="300"/>
            <col width="700"/>
            <thead>
              <tr valign="top">
                <td>Outcome</td>
                <td>Definition</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Earlier age of first sex</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Reported having had sex under the age of 16 years</p>
                    </list-item>
                    <list-item>
                      <p>Reported having had first sex under the age of 16 years</p>
                    </list-item>
                    <list-item>
                      <p>Reported mean age of population is below 16 years and participants reported having had sex</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Sex for payment OR paid sex</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Reported sex with sex workers</p>
                    </list-item>
                    <list-item>
                      <p>Reported having paid or received payment for sex</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Other sexual behaviors</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Reported having had condomless sex</p>
                    </list-item>
                    <list-item>
                      <p>Sex with multiple partners or group sex (&#62;1)</p>
                    </list-item>
                    <list-item>
                      <p>Multiple sexual partners over lifetime (&#62;1)</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Adverse sexual health consequences</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Teenage pregnancy</p>
                    </list-item>
                    <list-item>
                      <p>Reported history of STI<sup>a</sup></p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Sexual aggression OR violence indicative of forced sex (described scale must include forced sex)</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Reported perpetration of forced sex (defined or indicative of penetration)</p>
                    </list-item>
                    <list-item>
                      <p>Reported being a survivor of forced sex (defined or indicative of penetration)</p>
                    </list-item>
                  </list>
                </td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>STI: sexually transmitted infection.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Data Extraction</title>
        <p>The first author (PP) conducted the search and removed duplicates using EndNote X9 [<xref ref-type="bibr" rid="ref30">30</xref>]. PP reviewed the titles and abstracts (N=5852) and reviewed the full text (n=337) for eligibility (<xref rid="figure1" ref-type="fig">Figure 1</xref>). In cases of doubt (n=7), another author (SRS) was consulted. A total of 19 studies were eligible for inclusion. Information about the study location, design, sample size calculation, participants, setting, exposures, outcomes, control variables, methods of statistical analysis, effect sizes, and their variations were extracted by PP and MR. Where possible, effect sizes were calculated from the data if not reported through the study. Included studies either reported on sex or gender. For this systematic review, we used male/female/nonbinary gender or male/female sex to describe the gender or sex of the cohorts as reported in each study.</p>
      </sec>
      <sec>
        <title>Quality Assessment</title>
        <p>Study quality was assessed independently by the authors PP and MR using the Newcastle-Ottawa Scale [<xref ref-type="bibr" rid="ref31">31</xref>]. For the Newcastle-Ottawa scale used to assess longitudinal studies, we replaced the item “was follow-up long enough for outcome to occur” with “whether the outcome was assessed to be at low levels at baseline.” Cross-sectional studies were assessed based on the representativeness of the sample, sample size, addressing the influence of nonrespondents on the reported effect estimates, exposure, and outcome, reporting of statistical analyses, and comparison of outcome and control groups (<xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref> [<xref ref-type="bibr" rid="ref32">32</xref>-<xref ref-type="bibr" rid="ref50">50</xref>]). Longitudinal studies were assessed based on the representativeness of the sample, selection of a nonexposed cohort, assessment of exposure, outcome (at baseline and subsequent waves), follow-up rates, and comparability of outcome and control groups (<xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>). In cases of conflicts, 2 other authors (ML and JM) were consulted. Low risk of bias was classified as a score of ≥7, moderate risk of bias as a score of 4 to 6, and high risk of bias as a score of 0 to 3.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Included Studies</title>
        <p>Initial searches identified 5852 abstracts, and 19 studies met the inclusion criteria (<xref rid="figure1" ref-type="fig">Figure 1</xref>). This included 11 cross-sectional studies [<xref ref-type="bibr" rid="ref32">32</xref>-<xref ref-type="bibr" rid="ref42">42</xref>], 2 case-control studies [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>], and 6 prospective cohort studies [<xref ref-type="bibr" rid="ref45">45</xref>-<xref ref-type="bibr" rid="ref50">50</xref>]. Furthermore, 8 studies addressed early age (&#60;16 years) of first sex [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>]; 5 studies addressed sexual behaviors including condomless sex [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>]; 2 studies examined multiple sexual partners during lifetime; a single study examined group sex [<xref ref-type="bibr" rid="ref35">35</xref>]; 3 studies examined coercive or forced sex [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>]; and 5 studies examined other behaviors including paid sex [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref45">45</xref>], teenage pregnancy [<xref ref-type="bibr" rid="ref44">44</xref>], and history of sexually transmitted infections [<xref ref-type="bibr" rid="ref36">36</xref>].</p>
        <p>The included studies were conducted across 13 countries (<xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>), and 2 studies were conducted internationally across various countries in Europe [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref40">40</xref>] (<xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>). Most studies were conducted in European countries (n=9) [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref50">50</xref>], followed by countries in Asia (n=6) [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref47">47</xref>], the United States (n=3) [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref42">42</xref>], and Eastern Uganda (n=1) [<xref ref-type="bibr" rid="ref34">34</xref>]. Ten studies reported on the frequency of pornography exposure [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref50">50</xref>], and of these studies, one [<xref ref-type="bibr" rid="ref33">33</xref>] reported “regular” exposure without further definition. Four studies reported exposure to different pornography contents [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref42">42</xref>], including violent pornography (aggressive sexual acts) and pornography with condomless sex (<xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>). Exposure to pornography was not uniformly measured; 7 studies did not define pornography in their methods [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref45">45</xref>] and a further 6 studies defined it as “sexually explicit content,” “adult content,” “banned media,” or “R-rated media” [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref47">47</xref>] (<xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>). Similarly, the definitions of outcomes varied across studies. Age at first sex was measured prospectively in one study by asking at each follow-up whether an adolescent had ever had sexual intercourse [<xref ref-type="bibr" rid="ref50">50</xref>] and retrospectively in 2 studies by asking the age at first sexual intercourse [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref41">41</xref>]. Another longitudinal study assessed the outcome of the first sexual experience in a sexually naive population at baseline, with a mean age at baseline of &#60;16 years [<xref ref-type="bibr" rid="ref48">48</xref>]. Four studies had a mean sample age of &#60;16 years, so any participant in these samples who had sexual intercourse was considered to have had a young age of first sex [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>]. “Multiple sexual partners” included an adolescent self-reporting sex with more than one partner over their lifetime (n=2) [<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>] and having ever participated in group sex (n=1) [<xref ref-type="bibr" rid="ref35">35</xref>]. Studies of forced or coercive sex included participants as perpetrators (n=3) [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>] and survivors (n=2) [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref39">39</xref>]. Studies of paid sex included participants as buyers (n=3) [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref45">45</xref>] or sellers (n=2) [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref45">45</xref>]. Because of the heterogeneity in how exposure and outcomes were measured across studies, a meta-analysis was not possible.</p>
      </sec>
      <sec>
        <title>Early Age of First Sex</title>
        <p>A total of 8 studies (2 prospective cohorts, 1 case-control, and 5 cross-sectional) assessed the relationship between pornography exposure in adolescence and earlier age of first sex (defined as below the age of 16 years; <xref ref-type="table" rid="table2">Table 2</xref> [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>]). Of the 6 cross-sectional studies that examined this outcome, 2 studies [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref41">41</xref>] assessed only male adolescents, whereas the other 4 studies [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>] studied cohorts of both males and females and the analysis was not stratified by sex. Two prospective cohort studies reported conflicting findings regarding this association. The first study, of 639 male adolescents, conducted in Belgium [<xref ref-type="bibr" rid="ref50">50</xref>] found a positive longitudinal relationship between exposure to pornography and an earlier age of first sex. The second study [<xref ref-type="bibr" rid="ref48">48</xref>] reported no association between exposure to pornography and an earlier age of first sex in the overall sample. However, adolescents with a later age of first exposure to pornography had a significantly lower probability of reporting first sexual experience in subsequent waves than their counterparts with earlier exposure to porn. Subsequent sensitivity analyses to account for missing values showed no major association between the timing of porn exposure and first sex in males but showed an association between regular exposure to porn versus no exposure and first sex in females [<xref ref-type="bibr" rid="ref48">48</xref>]. Both studies were assessed to have a low risk of bias. Four cross-sectional studies of low to moderate risk of bias conducted in Sweden [<xref ref-type="bibr" rid="ref35">35</xref>], Thailand [<xref ref-type="bibr" rid="ref32">32</xref>], Eastern Uganda [<xref ref-type="bibr" rid="ref34">34</xref>], and 23 EU countries [<xref ref-type="bibr" rid="ref40">40</xref>] supported this association. Two studies did not identify any substantial associations. In 2013, Sahay et al [<xref ref-type="bibr" rid="ref43">43</xref>] presented a <italic>P</italic> value close to the threshold and conjectured that the rarity of the outcome in their sample limited the power to detect a true association.</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Reported associations between pornography exposure and early age of first sex.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="30"/>
            <col width="100"/>
            <col width="0"/>
            <col width="100"/>
            <col width="0"/>
            <col width="200"/>
            <col width="0"/>
            <col width="110"/>
            <col width="0"/>
            <col width="170"/>
            <col width="0"/>
            <col width="260"/>
            <thead>
              <tr valign="top">
                <td colspan="4">Study (year)</td>
                <td colspan="2">Country of study</td>
                <td colspan="2">Sample size, n (% F/M/NB<sup>a</sup>, gender or F/M sex as reported) and age for analyzed sample, mean (SD)</td>
                <td colspan="2">Risk of bias</td>
                <td colspan="2">Effect estimate, <italic>P</italic> value</td>
                <td>Comment on association</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="13">
                  <bold>Outcome is reporting the age of first sex below 16 years</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="12">
                  <bold>Cross sectional studies</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Donevan et al [<xref ref-type="bibr" rid="ref35">35</xref>] (2017)</td>
                <td colspan="2">Sweden</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>370 (100% male); NR<sup>b</sup> (only analyzed 18-year-old males)</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Low</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Mean age (at first vaginal sex) for frequent viewers is 14.50 years vs average users is 15.61 years vs infrequent users is 15.25 years (<italic>P</italic>=.001).</p>
                    </list-item>
                    <list-item>
                      <p>Overall mean age at first vaginal sex is 15.42 years</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Frequent users were more likely to try out sexual acts seen in pornography (<italic>P</italic>=.002)</p>
                    </list-item>
                    <list-item>
                      <p>Mean age at first anal sex is &#62;16 years</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Svedin et al [<xref ref-type="bibr" rid="ref41">41</xref>] (2011)</td>
                <td colspan="2">Sweden</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Reference group of nonfrequent viewers of pornography, 13.5% of n=1429-1702 (100% male)</p>
                    </list-item>
                    <list-item>
                      <p>Frequent users of pornography, 19.5% of n=172-200 (100% male)</p>
                    </list-item>
                    <list-item>
                      <p>Overall, 18.15 (0.74) years</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Low</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>AOR<sup>c</sup> 0.77, 95% CI 0.48-1.23; <italic>P</italic>=.27</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Frequent users were also more likely to report believing porn to be one of the best ways to learn about sex (38.1% vs 18.1%; <italic>P</italic>&#60;.001)</p>
                    </list-item>
                    <list-item>
                      <p>Adjusted for other covariates including background sociodemographic status, parental relationship, problems in conduct, and other sexual behaviors</p>
                    </list-item>
                    <list-item>
                      <p>Significant when nonadjusted</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td colspan="13">
                  <bold>Outcome is reporting of any sex, but mean age of cohort is below 16 years</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="12">
                  <bold>Cross-sectional study</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Atwood et al [<xref ref-type="bibr" rid="ref32">32</xref>] (2012)</td>
                <td colspan="2">Thailand</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>420 (50.5% female)</p>
                    </list-item>
                    <list-item>
                      <p>13.45 (0.5) years</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Moderate</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>AOR 2.73, 95% CI 1.25-5.96; <italic>P</italic>&#60;.01</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Adjusted for parental relationships, relationship status, sex refusal, and self-efficacy</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Bukenya [<xref ref-type="bibr" rid="ref34">34</xref>] (2020)</td>
                <td colspan="2">Uganda</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>598 (52% male)</p>
                    </list-item>
                    <list-item>
                      <p>14.2 (2.6) years</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Low</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>AOR 2.29, 95% CI 1.60-3.29; <italic>P</italic>=NR</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>46.3% of sample was aged 15-19 years</p>
                    </list-item>
                    <list-item>
                      <p>Adjusted for covariates including age, education level, parental relationship, substance use, sexing experience, history of being bullied, experienced physical arrack, intentions of participating in verbal sex jokes, and engagement in labor activities</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Sahay [<xref ref-type="bibr" rid="ref43">43</xref>] (2013)</td>
                <td colspan="2">India</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>205 (47% female)</p>
                    </list-item>
                    <list-item>
                      <p>14.6 (NR) years</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Moderate</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>AOR 2.6, 95% CI 0.95-7.05; <italic>P</italic>=.06</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Low proportion of population reporting outcome; 31.7% (13/41) of case defined as having ever had an intimate relationship, and 28.6% (44/164) of control were aged 16-19 years</p>
                    </list-item>
                    <list-item>
                      <p>Adjusted for medium of instruction, access to sexual health material, history of sexual abuse, parental relationship, and reported STD<sup>d</sup> symptoms</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Ševčíková et al [<xref ref-type="bibr" rid="ref40">40</xref>] (2014)</td>
                <td colspan="2">EU countries</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>11,712 (50% female)</p>
                    </list-item>
                    <list-item>
                      <p>Overall mean age NR, but across categories of porn exposure, mean age ranged from 13.24 to 14.12 years</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Low</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>AOR 3.25; β<sup>e</sup>=1.18, SE 0.12; <italic>P</italic>&#60;.01</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Adjusted for restrictive parental mediation, gender, and national location (indicative of liberalism in wider context); model particularly adjusted for these variables, not covariates</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="12">
                  <bold>Prospective cohort study</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td colspan="11">
                  <bold>Matković et al [<xref ref-type="bibr" rid="ref48">48</xref>] (2018)</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td rowspan="2"/>
                <td colspan="2">Croatia (Rijeka)</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>866 (39% male)</p>
                    </list-item>
                    <list-item>
                      <p>At baseline, n=1037, 15.8 (0.5) years</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Low</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Moderately frequent exposure</p>
                    </list-item>
                    <list-item>
                      <p>Male: β=0.89, SE 0.59; <italic>P</italic>=.128</p>
                    </list-item>
                    <list-item>
                      <p>Female: β=0.09, SE 0.29; <italic>P</italic>=.754</p>
                    </list-item>
                    <list-item>
                      <p>Most frequent exposure</p>
                    </list-item>
                    <list-item>
                      <p>Male: β=0.14, SE 0.69; <italic>P</italic>=.837</p>
                    </list-item>
                    <list-item>
                      <p>Female: β=0.76, SE0.39; <italic>P</italic>=.051</p>
                    </list-item>
                    <list-item>
                      <p>Age of exposure to porn, males: β=−1.72 to −1.79; <italic>P</italic>&#60;.05</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Adjusted for pubertal status, education (school type), age at first exposure to porn, age, parental mediation, sexual intention (in the form of sensation seeking), and a contextual variable indicative of peer participation in sex.</p>
                    </list-item>
                    <list-item>
                      <p>Compared with males with earliest exposure to porn, those who had later exposure to porn had significantly lower probability of reporting the outcome.</p>
                    </list-item>
                    <list-item>
                      <p>Nonsignificant in females</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td colspan="2">Croatia<break/>(Zagreb)</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>n=793</p>
                    </list-item>
                    <list-item>
                      <p>At baseline, 16.1 (0.44) years, and 67.8% female</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <break/>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>β=0.63; <italic>P</italic>&#60;.05</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Replication analysis, associations in Rijeka panel were not corroborated</p>
                    </list-item>
                    <list-item>
                      <p>Analysis is comparing regular users of porn to those who do not use porn</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Vandenbosch et al [<xref ref-type="bibr" rid="ref50">50</xref>] (2013)</td>
                <td colspan="2">Belgium</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>584 (58% male in overall population of n=639)</p>
                    </list-item>
                    <list-item>
                      <p>14.78 (1.18) years at baseline, study is in 2 waves, 6 months apart</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Low</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>AOR 4.96, 95% CI 1.34-18.40; <italic>P</italic>=.02</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Comparing frequent users of pornography to nonfrequent users</p>
                    </list-item>
                    <list-item>
                      <p>Adjusted for variables by including control variables such as country of origin, gender, age, educational level, parental relationships, peer communication, and sensation seeking, which were added as predictors in analyses at wave 2</p>
                    </list-item>
                  </list>
                </td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table2fn1">
              <p><sup>a</sup>F/M/NB: female/male/nonbinary.</p>
            </fn>
            <fn id="table2fn2">
              <p><sup>b</sup>NR: not reported.</p>
            </fn>
            <fn id="table2fn3">
              <p><sup>c</sup>AOR: adjusted odds ratio.</p>
            </fn>
            <fn id="table2fn4">
              <p><sup>d</sup>STD: sexually transmitted disease.</p>
            </fn>
            <fn id="table2fn5">
              <p><sup>e</sup>β: unstandardized regression coefficient.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Condomless Sex</title>
        <p>A total of 5 studies (3 prospective cohorts, 1 case-control, and 1 cross-sectional) assessed the relationship between pornography exposure in adolescence and participation in condomless sex (<xref ref-type="table" rid="table3">Table 3</xref> [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>]). Two studies [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref42">42</xref>] were conducted in the United States, and one each in Croatia [<xref ref-type="bibr" rid="ref46">46</xref>], Taiwan [<xref ref-type="bibr" rid="ref47">47</xref>] and the Netherlands [<xref ref-type="bibr" rid="ref49">49</xref>]. The largest study assessing this outcome was a prospective cohort study of 2054 participants conducted in Taiwan [<xref ref-type="bibr" rid="ref47">47</xref>], and the smallest was a cross-sectional study of 206 participants conducted in the United States [<xref ref-type="bibr" rid="ref37">37</xref>]. Of the 2 cross-sectional studies that examined this outcome, one studied a cohort of male adolescents [<xref ref-type="bibr" rid="ref37">37</xref>], whereas the other examined a cohort of males and females, where analysis was not stratified by gender [<xref ref-type="bibr" rid="ref42">42</xref>]. The 3 longitudinal studies reported cohorts of male and female adolescents, where the analysis was not stratified by sex. However, one study [<xref ref-type="bibr" rid="ref46">46</xref>] included gender as an interaction term to analyze the effects of gender on the association, while another [<xref ref-type="bibr" rid="ref47">47</xref>] adjusted for gender in the regression models.</p>
        <p>The results of these studies were mixed. Among 3 longitudinal studies [<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>], one conducted in Taiwan [<xref ref-type="bibr" rid="ref47">47</xref>] reported a positive association and was assessed to have a moderate risk of bias, while the studies from Croatia and the Netherlands [<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref49">49</xref>] reported no major associations and were assessed to have a low risk of bias. Both cross-sectional studies supported a positive association between exposure to pornography and condomless sex in the samples [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref42">42</xref>]. Nelson et al (2019) examined pornography patterns in non-heterosexual male adolescents [<xref ref-type="bibr" rid="ref40">40</xref>], a study that was assessed to have a low risk of bias. Specifically, this study found that those who viewed more condomless sex (&#62;50% of total pornography viewed) were more likely to have reported participating in condomless sex [<xref ref-type="bibr" rid="ref37">37</xref>]. Another cross-sectional study that found an association, by Wright et al [<xref ref-type="bibr" rid="ref42">42</xref>], was assessed to have a high risk of bias owing to poor adjustment of confounders and ascertainment of exposures and outcomes.</p>
        <table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Reported associations between pornography exposure and sexual behaviors.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="30"/>
            <col width="120"/>
            <col width="120"/>
            <col width="170"/>
            <col width="140"/>
            <col width="170"/>
            <col width="220"/>
            <thead>
              <tr valign="top">
                <td colspan="3">Study (year)</td>
                <td>Country of study</td>
                <td>Sample size, n (% F/M/NB<sup>a</sup>, gender or F/M sex as reported) and age for analyzed sample, mean (SD)</td>
                <td>Risk of bias</td>
                <td>Effect estimate, <italic>P</italic> value</td>
                <td>Comment on association</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="8">
                  <bold>Condomless sex</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="7">
                  <bold>Cross-sectional studies</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Nelson et al [<xref ref-type="bibr" rid="ref37">37</xref>] (2019)</td>
                <td>United States</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>206 (100% male)</p>
                    </list-item>
                    <list-item>
                      <p>16 (1.0) years</p>
                    </list-item>
                  </list>
                </td>
                <td>Low</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>AOR<sup>b</sup> 2.4, 95% CI 1.1-5.2; <italic>P</italic>=NR<sup>c</sup></p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Referred comparator group is those who reported &#60;50% of porn viewed contains condomless anal sex</p>
                    </list-item>
                    <list-item>
                      <p>Adjusted for age and ethnicity</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Wright [<xref ref-type="bibr" rid="ref42">42</xref>] (2020)</td>
                <td>United States</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>n=95 adolescents who reported having had intercourse in the last year (56.6% female)</p>
                    </list-item>
                    <list-item>
                      <p>45.4% of case are aged 18 years</p>
                    </list-item>
                  </list>
                </td>
                <td>High</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>OR<sup>d</sup> 1.92, 95% CI 1.23-2.98; <italic>P</italic>=NR</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Odds ratio increased to 2.97 (1.48-5.93) when parents did not discuss any topics about sexual health</p>
                    </list-item>
                    <list-item>
                      <p>Parental communication about sex was used as a conditional variable</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="7">
                  <bold>Prospective cohort studies</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Koletić et al [<xref ref-type="bibr" rid="ref46">46</xref>] (2019)</td>
                <td>Croatia</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Zagreb cohort: at baseline: n=1057, (35.6% male), 16.14 (0.45) years; analyzed sample in model, n=246</p>
                    </list-item>
                    <list-item>
                      <p>Rijeka cohort: at baseline: n=1071 (38.4% male), 15.82 (0.49) years; analyzed sample in model, n=297</p>
                    </list-item>
                  </list>
                </td>
                <td>Low</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Zagreb cohort: AOR 1.02, 95% CI 0.84-1.24; <italic>P</italic>&#62;.05</p>
                    </list-item>
                    <list-item>
                      <p>Rijeka cohort: AOR 0.99, 95% CI 0.78-1.28; <italic>P</italic>&#62;.05</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Association was nonsignificant in nonadjusted model; potential correlation between initial baseline exposure to porn and condomless sex at final time point not examined</p>
                    </list-item>
                    <list-item>
                      <p>Adjusted for parents’ education, age, pubertal timing, sensation seeking, and multiple partners; interaction term of gender and pornography use was found to be nonsignificant</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Lin et al [<xref ref-type="bibr" rid="ref47">47</xref>] (2020)</td>
                <td>Taiwan</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>N=2054 (51% male at baseline, n=2690)</p>
                    </list-item>
                    <list-item>
                      <p>At baseline, 13.3 (0.49) years</p>
                    </list-item>
                  </list>
                </td>
                <td>Moderate</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>β<sup>e</sup>=0.274, SE 0.131; <italic>P</italic>&#60;.05</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Adjusted for gender, parental education level, socioeconomic status, socioeconomic status, status of family (including cohesion, number of siblings), education level, relationship status, history of depressive symptoms, and impact of participant’s school</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Peter et al [<xref ref-type="bibr" rid="ref49">49</xref>] (2011)</td>
                <td>The Netherlands</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>N=1445 (51% male); at baseline, 14.49 (1.68) years</p>
                    </list-item>
                  </list>
                </td>
                <td>Low</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>AOR 0.980, 95% CI 0.658-1.459; <italic>P</italic>=NS<sup>f</sup></p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Association was significant in the adult cohort; when age interaction terms were included in logistic regression models, nonsignificant associations were observed across both cohorts</p>
                    </list-item>
                    <list-item>
                      <p>Controlled for sensation seeking, life satisfaction, peer relationships, sexual orientation, relationship status, number of lifetime sex partners, and casual condomless sexual behavior of friends</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td colspan="8">
                  <bold>Group sex</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="7">
                  <bold>Cross-sectional studies</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Donevan and Mattebo [<xref ref-type="bibr" rid="ref35">35</xref>] (2017)</td>
                <td>Sweden</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>370 (100% male), NR (18-year-olds); adolescents who reported having had group sex (n=23)</p>
                    </list-item>
                  </list>
                </td>
                <td>Low</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>OR 1.65, 95% CI .48-5.73; <italic>P</italic>&#62;.05</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Odds ratio calculated by this review’s authors</p>
                    </list-item>
                    <list-item>
                      <p>Frequent and average users of porn as reported by study were used as the exposed group; infrequent users were used as the control group</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td colspan="8">
                  <bold>Lifetime sexual partners</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="7">
                  <bold>Prospective cohort studies</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Koletić et al [<xref ref-type="bibr" rid="ref46">46</xref>] (2019)</td>
                <td>Croatia</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Zagreb cohort: at baseline: n=1057, (35.6% male), 16.14 (0.45) years; analyzed sample in model, n=246</p>
                    </list-item>
                    <list-item>
                      <p>Rijeka cohort: at baseline: n=1071 (38.4% male), 15.82 (0.49) years; analyzed sample in model, n=293</p>
                    </list-item>
                  </list>
                </td>
                <td>Low</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Zagreb cohort: AOR 1.31, 95% CI 0.94-1.73; <italic>P</italic>&#62;.05</p>
                    </list-item>
                    <list-item>
                      <p>Rijeka cohort: AOR 1.05, 95% CI .77-1.43; <italic>P</italic>&#62;.05</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Association was significant in nonadjusted model; potential correlation between initial baseline exposure to porn and condomless sex at final time point not examined</p>
                    </list-item>
                    <list-item>
                      <p>Adjusted for parents’ education, age, pubertal timing, sensation seeking, and multiple partners; interaction term of gender and pornography use was found to be nonsignificant</p>
                    </list-item>
                    <list-item>
                      <p>Assessed 2 or more sexual partners over lifetime</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Lin, Liu, and Yi [<xref ref-type="bibr" rid="ref47">47</xref>] (2020)</td>
                <td>Taiwan</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>N=1477 (51% male at baseline, n=2690); at baseline, 13.3 (0.49)</p>
                    </list-item>
                  </list>
                </td>
                <td>Moderate</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>β=2.725, SE 1.059; <italic>P</italic>&#60;.05</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Positive significant association when exposure considers multiple media (internet, magazines, etc) of porn rather than specific types of pornography</p>
                    </list-item>
                    <list-item>
                      <p>Adjusted for gender, parental education level, socioeconomic status, socioeconomic status, status of family (including cohesion, number of siblings), education level, relationship status, history of depressive symptoms, and impact of participant’s school</p>
                    </list-item>
                    <list-item>
                      <p>Assessed 2 or more sexual partners over lifetime</p>
                    </list-item>
                  </list>
                </td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table3fn1">
              <p><sup>a</sup>F/M/NB: female/male/nonbinary.</p>
            </fn>
            <fn id="table3fn2">
              <p><sup>b</sup>AOR: adjusted odds ratio.</p>
            </fn>
            <fn id="table3fn3">
              <p><sup>c</sup>NR: not reported.</p>
            </fn>
            <fn id="table3fn4">
              <p><sup>d</sup>OR: odds ratio.</p>
            </fn>
            <fn id="table3fn5">
              <p><sup>e</sup>β: unstandardized regression coefficient.</p>
            </fn>
            <fn id="table3fn6">
              <p><sup>f</sup>NS: nonsignificant <italic>P</italic> value.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Multiple Sexual Partners</title>
        <p>Two prospective studies examined the association between pornography exposure and multiple lifetime sexual partners [<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>]. These studies were conducted in Croatia [<xref ref-type="bibr" rid="ref46">46</xref>] and Taiwan [<xref ref-type="bibr" rid="ref47">47</xref>]. Both studies examined male and female cohorts. Koletić et al [<xref ref-type="bibr" rid="ref46">46</xref>] included gender as an interaction term to analyze the effects of gender on the association, whereas Lin et al [<xref ref-type="bibr" rid="ref47">47</xref>] adjusted for gender in the regression models. The study by Lin et al, 2020 [<xref ref-type="bibr" rid="ref47">47</xref>] found an association between pornography exposure and multiple sexual partners and was assessed to have a moderate risk of bias owing to not measuring the outcome at baseline, having a low proportion of the sample reporting the outcome, and limited assessment of follow-up and retention rates (<xref ref-type="table" rid="table3">Table 3</xref>). This study reported exposure to pornography across different media (such as comic books and web sites) in a single exposure variable. Koletić et al [<xref ref-type="bibr" rid="ref46">46</xref>] found a major association but only in a nonadjusted model. A single cross-sectional study conducted in Sweden on a cohort of male adolescents reported a nonsignificant association between exposure to pornography and participation in group sex [<xref ref-type="bibr" rid="ref35">35</xref>], that is, sex with multiple partners simultaneously (<xref ref-type="table" rid="table1">Tables 1</xref> and <xref ref-type="table" rid="table3">3</xref>).</p>
      </sec>
      <sec>
        <title>Forced or Coercive Sex</title>
        <p>A total of three cross-sectional studies [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>] assessed the relationship between pornography exposure in adolescence and experiences of forced or coercive penetrative sex (<xref ref-type="table" rid="table4">Table 4</xref>). These studies were conducted in the United States [<xref ref-type="bibr" rid="ref39">39</xref>], Sweden [<xref ref-type="bibr" rid="ref41">41</xref>] and 5 European countries [<xref ref-type="bibr" rid="ref33">33</xref>]. The largest study was by Barter et al [<xref ref-type="bibr" rid="ref33">33</xref>] in 2021 of 3277 adolescents, and the smallest was conducted by Rostad et al [<xref ref-type="bibr" rid="ref39">39</xref>] in 2019 with 1766 adolescents. Furthermore, 2 out of 3 studies reported a major positive association in reported experiences of forced or coercive sex in males only [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref39">39</xref>]. Two of the 3 studies [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref39">39</xref>] stratified their analyses as male or female, and one of the studies examined only male adolescents [<xref ref-type="bibr" rid="ref33">33</xref>].</p>
        <table-wrap position="float" id="table4">
          <label>Table 4</label>
          <caption>
            <p>Reported associations between pornography exposure and forced/coercive sex, paid sex, teenage pregnancy, and history of sexually transmitted infection.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="30"/>
            <col width="160"/>
            <col width="0"/>
            <col width="130"/>
            <col width="0"/>
            <col width="170"/>
            <col width="0"/>
            <col width="110"/>
            <col width="0"/>
            <col width="170"/>
            <col width="0"/>
            <col width="200"/>
            <thead>
              <tr valign="top">
                <td colspan="4">Study (year)</td>
                <td colspan="2">Country of study</td>
                <td colspan="2">Sample size, n (% F/M/NB<sup>a</sup>, gender or F/M sex as reported) and age for analyzed sample, mean (SD)</td>
                <td colspan="2">Risk of bias</td>
                <td colspan="2">Effect estimate, <italic>P</italic> value</td>
                <td>Comment on association</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="13">
                  <bold>Forced or coercive sex</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="12">
                  <bold>Cross-sectional studies</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Rostad et al [<xref ref-type="bibr" rid="ref39">39</xref>] (2019)</td>
                <td colspan="2">United States</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>N=1766 responded (52.3% female), 15.42 (0.65) years</p>
                    </list-item>
                    <list-item>
                      <p>Analysis performed on: n=746 (female) and n=578 (male)</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Low</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Male victimization: AOR<sup>b</sup> 2.60, 95% CI 1.40-4.83</p>
                    </list-item>
                    <list-item>
                      <p>Female victimization: AOR 1.63, 95% CI 0.96-2.76</p>
                    </list-item>
                    <list-item>
                      <p>Male perpetration: AOR 3.34, 95% CI 1.85-6.04</p>
                    </list-item>
                    <list-item>
                      <p>Female perpetration: AOR 0.99, 95% CI 0.39-2.55</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Adjusted for age, socioeconomic status, substance use, history of suspension or expulsion from school, tolerance of rape myths, attitudes based on gender, experiences of drinking, and marijuana use</p>
                    </list-item>
                    <list-item>
                      <p>Analysis stratified by gender</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Svedin et al [<xref ref-type="bibr" rid="ref41">41</xref>] (2011)</td>
                <td colspan="2">Sweden</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Overall, 18.15 (0.74) years</p>
                    </list-item>
                    <list-item>
                      <p>Analyzed sample: n=172-200 (100% male) adolescents who were frequently exposed to porn; n=1429-1702 (100% male) reference group of male adolescents who were less frequently exposed to porn</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Low</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>AOR 1.49, 95% CI 0.80-2.76; <italic>P</italic>=.18</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Adjusted for other covariates including background sociodemographic status, parental relationship, problems in conduct, and other sexual behaviors</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Barter et al [<xref ref-type="bibr" rid="ref33">33</xref>] (2021)</td>
                <td colspan="2">England, Italy, Norway, Bulgaria, and Cyprus</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>N=4564 (NR<sup>c</sup>)</p>
                    </list-item>
                    <list-item>
                      <p>NR (14-17) years (14.7 years in England and 15.3 years in Italy)</p>
                    </list-item>
                    <list-item>
                      <p>Analysis conducted on n=3277</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Low</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Male perpetration: AOR 2.46, 95% CI 1.80-3.34</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Nonsignificant association in females, not reported</p>
                    </list-item>
                    <list-item>
                      <p>Adjusted for age, country of residence, negative gender attitudes, aggression in peers, experiences of bullying, and violence in household</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td colspan="13">
                  <bold>Paid sex (bought sex)</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="12">
                  <bold>Cross-sectional studies</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Ng and Wong [<xref ref-type="bibr" rid="ref38">38</xref>]<sup>d</sup> (2016)</td>
                <td colspan="2">Singapore</td>
                <td colspan="2">300 (100% male), median=8 (IQR 18-19) years</td>
                <td colspan="2">Low</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>AOR 1.47, 95% CI 1.04-2.09</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Adjusted for alcohol consumption, rebellious attitudes, self-esteem, perceived external control, academic performance, participation in cocurricular activities, age of first sex, and history of having a sexually active girlfriend</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Svedin et al [<xref ref-type="bibr" rid="ref41">41</xref>] (2011)</td>
                <td colspan="2">Sweden</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Overall, 18.15 (0.74) years</p>
                    </list-item>
                    <list-item>
                      <p>Analyzed sample: n=172-200 (100% male) adolescents who were frequently exposed to porn; n=1429-1702 (100% male) reference group of male adolescents who were less frequently exposed to porn</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Low</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>AOR 1.71, 95% CI .71-4.14; <italic>P</italic>=.23</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Adjusted for background sociodemographic status, parental relationship, problems in conduct, early ages of first sex, paid sex, experiences of sexual aggression, and perceived feelings of sexual lust</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="12">
                  <bold>Prospective cohort studies</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Averdijk [<xref ref-type="bibr" rid="ref45">45</xref>] (2020)</td>
                <td colspan="2">Switzerland</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>602 (males only)</p>
                    </list-item>
                    <list-item>
                      <p>At baseline (n=1675), overall: 13.7 (0.37) years</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Moderate</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>OR<sup>e</sup> 1.284; β coefficient 0.250; <italic>P</italic>&#60;.01</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Stratified by gender, analyzed males only owing to no prevalence of outcome in females</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td colspan="13">
                  <bold>Paid sex (sold sex)</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="12">
                  <bold>Cross-sectional studies</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Svedin et al [<xref ref-type="bibr" rid="ref41">41</xref>] (2011)</td>
                <td colspan="2">Sweden</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Overall, 18.15 (0.74) years</p>
                    </list-item>
                  </list>
                  <list list-type="bullet">
                    <list-item>
                      <p>Analyzed sample: n=172-200 (100% male) adolescents who were frequently exposed to porn; n=1429-1702 (100% male) reference group of male adolescents who were less frequently exposed to porn</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Low</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>AOR 2.68, 95% CI 1.13-6.35; <italic>P</italic>=.03</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Adjusted for background sociodemographic status, parental relationship, problems in conduct, other sexual behaviors, and perceived feelings of sexual lust</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="12">
                  <bold>Prospective cohort studies</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Averdijk [<xref ref-type="bibr" rid="ref45">45</xref>] (2020)</td>
                <td colspan="2">Switzerland</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>1197 (52% of target population, n=1675 is male)</p>
                    </list-item>
                    <list-item>
                      <p>At baseline: 13.7 (0.37) years</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Moderate</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>AOR 0.463; B coefficient −0.770; <italic>P</italic>&#60;.01</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Association is conditional on gender; high levels of porn use amplified the difference (females had a higher level of selling sex than males)</p>
                    </list-item>
                    <list-item>
                      <p>Odds ratio was adjusted for gender by including it as an interaction term</p>
                    </list-item>
                    <list-item>
                      <p>Unadjusted model was nonsignificant</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td colspan="13">
                  <bold>Teenage pregnancy</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="12">
                  <bold>Case-control analysis</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Siti-HaidahSiti-Haidah et al [<xref ref-type="bibr" rid="ref44">44</xref>] (2017)</td>
                <td colspan="2">Malaysia</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>215 (100% female)</p>
                    </list-item>
                    <list-item>
                      <p>75% above 15, age range of 12-19 years</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Moderate</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>AOR 9.9, 95% CI 4.3-22.5; <italic>P</italic>&#60;.001</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Adjusted for background demographics including, ethnicity, socioeconomic status, and parental education</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td colspan="13">
                  <bold>History of sexually transmitted infections</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="12">
                  <bold>Cross-sectional studies</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Kim et al [<xref ref-type="bibr" rid="ref36">36</xref>] (2016)</td>
                <td colspan="2">South Korea</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>2387 (25.4% female)</p>
                    </list-item>
                    <list-item>
                      <p>NR (12-19 years age range)</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">Low</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Male: AOR 2.623, 95% CI 1.214-5.668</p>
                    </list-item>
                    <list-item>
                      <p>Female: AOR 14.00, 95% CI 2.150-91.170</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Analysis stratified by gender</p>
                    </list-item>
                  </list>
                </td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table4fn1">
              <p><sup>a</sup>F/M/NB: female/male/nonbinary.</p>
            </fn>
            <fn id="table4fn2">
              <p><sup>b</sup>AOR: adjusted odds ratio</p>
            </fn>
            <fn id="table4fn3">
              <p><sup>c</sup>NR: not reported.</p>
            </fn>
            <fn id="table4fn4">
              <p><sup>d</sup>Reported median age of cohort (IQR).</p>
            </fn>
            <fn id="table4fn5">
              <p><sup>e</sup>OR: odds ratio.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Paid Sex</title>
        <p>The relationship between pornography exposure and “paying for sex” was inconsistent (<xref ref-type="table" rid="table4">Table 4</xref>). Studies have been conducted in Singapore [<xref ref-type="bibr" rid="ref38">38</xref>], Sweden [<xref ref-type="bibr" rid="ref41">41</xref>], and Switzerland [<xref ref-type="bibr" rid="ref45">45</xref>]. A prospective cohort study [<xref ref-type="bibr" rid="ref45">45</xref>] reporting this exposure and outcome found a positive association between exposure to pornography and sex. This was supported by one [<xref ref-type="bibr" rid="ref38">38</xref>] of the 2 cross-sectional studies [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>] that examined this association. There are an insufficient number of studies examining both male and female adolescents to conclude whether this association was gender dependent, as both Ng et al [<xref ref-type="bibr" rid="ref38">38</xref>] and Svedin et al [<xref ref-type="bibr" rid="ref41">41</xref>] reported on male adolescents yet found opposing substantial associations. Regarding the outcome of selling sex, a prospective cohort study found no association with pornography viewing [<xref ref-type="bibr" rid="ref45">45</xref>]. However, they reported an interaction effect with gender, whereby females with high pornography consumption were more likely to sell sex than those with low consumption. One cross-sectional study [<xref ref-type="bibr" rid="ref41">41</xref>] that sampled only male adolescents found a positive association between selling sex and viewing pornography. There are an insufficient number of studies examining this association to draw conclusions.</p>
      </sec>
      <sec>
        <title>Sexual Health Consequences</title>
        <p>One study reported a major association between exposure to pornography and teenage pregnancy [<xref ref-type="bibr" rid="ref44">44</xref>], whereas another found an association with a history of sexually transmitted diseases [<xref ref-type="bibr" rid="ref36">36</xref>] (<xref ref-type="table" rid="table4">Table 4</xref>). The study of teenage pregnancy was assessed to have a moderate risk of bias, largely due to poor assessment of nonrespondents and limited justification of sample size. Both studies were limited by a lack of representative samples.</p>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <p>We identified 19 papers published in the past 10 years that reported the association between pornography exposure and sexual behaviors in adolescents. Our review found that exposure to pornography in adolescence is associated with an earlier age of first sex (below 16 years of age). Notably, recent studies with higher-quality evidence supported the existence of a relationship between exposure to pornography and earlier age of first sex for adolescents aged 10-19 years. Out of the studies, 4 cross-sectional studies [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>] and 1 longitudinal study found this association. Two cross-sectional studies did not report a significant association, with the study by Sahay et al [<xref ref-type="bibr" rid="ref43">43</xref>] limited by a low proportion of the population reporting the outcome, and the study by Svedin et al [<xref ref-type="bibr" rid="ref41">41</xref>] limited by the retrospective nature of the reported outcomes and the era in which data collection occurred (before access to smartphones and high-resolution internet video). Another longitudinal study by Matković [<xref ref-type="bibr" rid="ref48">48</xref>] also found inconsistent associations between pornography exposure and age of first sex, depending on how the exposure was measured (timing and quantity) and the gender of the adolescent. However, these were not consistently present in all analyses. The study was limited by the baseline mean age of the sample being 15.8 (SD 0.5) years and the fact that sexual debut soon after this age would be expected. A review by Peter and Valkenburg in 2016 [<xref ref-type="bibr" rid="ref19">19</xref>] also reported an association between pornography exposure and earlier age of sexual activity, and our review has strengthened this finding with the inclusion of additional, more recent studies. We did not find an association between exposure to pornography and any other sexual behaviors. Notably, a positive association between exposure to pornography and earlier age at first sex in adolescence does not imply a causal relationship, even when a temporal association is identified, as in a longitudinal study [<xref ref-type="bibr" rid="ref50">50</xref>]. For example, adolescents who are more interested in sexual activity and therefore more likely to become sexually active may also be more likely to view pornography because of their interest in it. Both Donevan et al [<xref ref-type="bibr" rid="ref35">35</xref>] and Svedin et al [<xref ref-type="bibr" rid="ref41">41</xref>] reported higher exposure to pornography in those seeking it as a source of inspiration or knowledge about sex.</p>
      <p>There was a limited number of studies, mainly cross-sectional, examining the relationship between exposure to pornography and forced sex, paid sex, multiple partners, teenage pregnancy, and history of sexually transmitted infection [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>-<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>]. There is clearly a need for more longitudinal studies to determine whether exposure to pornography is associated with other sexual behaviors in adolescents. In contrast to previous reviews [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref26">26</xref>], we examined forced penetrative sex separately from sexual aggression (aggressive intentions or coerced nonpenetrative sexual behaviors such as kissing or touching). We found mixed results, which might be clarified if the studies were to report these outcomes separately. We excluded some studies [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref52">52</xref>] where forced sex was measured only as “forced sexual acts” and hence accounted for forced sexual behaviors that are strictly not forced sexual intercourse, such as kissing or touching against one’s will. It is also worth noting that one study included in this review found an association between exposure to pornography and forced sex [<xref ref-type="bibr" rid="ref39">39</xref>] focused specifically on violent pornography, defined as any erotic media depicting individuals being forced into sexual acts. A recent meta-analysis found that violent pornography was modestly correlated with sexual aggression and noted difficulties in interpreting the data owing to citation biases and researcher expectancy effects [<xref ref-type="bibr" rid="ref53">53</xref>]. In addition, a systematic review conducted in 2021 aligned with our observations, noting the difficulty of clarifying the association between pornography consumption and nonconsensual acts such as rape [<xref ref-type="bibr" rid="ref54">54</xref>]. This may differ from the impact of nonviolent pornography, which has been associated with reduced sexual aggression in older populations [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]. It is possible that exposure to violent pornography is associated with sexually aggressive behavior.</p>
      <p>Before considering the significance of our findings, we recognize that our systematic review was not without its limitations, particularly the potential for missing literature. This may have been the case because our choice of search terms and databases was not sent for external peer review [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref28">28</xref>], and we excluded grey literature. However, using a wide array of databases spanning across multiple disciplines (<xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref>), consulting with an expert librarian, and searching citations of included articles, we conducted a comprehensive search to address the aims of this review. This review included studies from 13 different countries and 2 cross-national European studies (Appendix 4). Most studies were conducted in high-income Western settings. For multiple lifetime sexual partners, no major association with pornography exposure was found when the study was conducted in a Western country (Croatia) [<xref ref-type="bibr" rid="ref46">46</xref>], but there was an association in an Eastern country (Taiwan) [<xref ref-type="bibr" rid="ref47">47</xref>]. A similar pattern was identified for the outcomes of group sex, teenage pregnancy, and history of sexually transmitted infections (<xref ref-type="table" rid="table3">Tables 3</xref> and <xref ref-type="table" rid="table4">4</xref>), yet there are insufficient studies examining or comparing culturally diverse locations to draw conclusions. The role of cultural influence on the relationship between pornography exposure and sexual behaviors is under-studied in adolescents, but this review suggests that country and culture may be important. Several articles assessing the relationship between exposure to pornography and outcomes of sexual behavior in older populations have suggested the significance of cultural context as an influence on how susceptible an individual is to adopt the sexual scripts prescribed in pornography [<xref ref-type="bibr" rid="ref56">56</xref>-<xref ref-type="bibr" rid="ref58">58</xref>]. In certain cultures, where access to sexual health education is limited, adolescents tend to use pornography as one of the few sources of sexual health knowledge [<xref ref-type="bibr" rid="ref59">59</xref>]. It is possible that in societies without sex education, adolescents may more readily adopt sexual scripts presented in pornography [<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref61">61</xref>], normalizing sexual behaviors depicted in pornography. Despite this conjecture, the role of culture in adolescents’ exposure to pornography and its relationship with sexual behaviors remains unknown, and further studies are recommended.</p>
      <p>Inconsistent findings on the association between exposure to pornography in adolescence and sexual behavior also likely reflect the limitations of research studies. Consistent with a previous review [<xref ref-type="bibr" rid="ref19">19</xref>], we found that exposure to pornography was not assessed in a uniform or reproducible manner (<xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>). Nearly half of the studies did not define pornography in their methods, and a further 5 studies defined it simply as “sexually explicit content,” “adult content,” or “banned material.” A lack of specificity in exposure may impact a study’s ability to identify an existing association. It also prevents the pooling of data in a meta-analysis, limiting the ability to increase the power to detect an association. There is a clear need to standardize the definition and quantification of pornography. Two studies identified that adolescents commonly reported using pornography as an information source [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref41">41</xref>]. Such ideas align with previous findings that adolescents learn about sex, sexual identities, and sexuality through pornography [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]. Pornography content, perceptions of that content, frequency of use, and reasons for use are important dimensions of pornography exposure. A consistent and reliable measurement of these dimensions will help elucidate the pathways between pornography and sexual behavior in adolescents. In addition, as in the case of studies assessing sexual aggression indicative of forced sex (<xref ref-type="table" rid="table4">Table 4</xref> and <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>), questionnaires assessing sexual behaviors require careful piloting and validation to ensure that they are understood by adolescents as intended. Furthermore, statistical analyses that do not combine forced sex with other sexually aggressive acts into one outcome can help to further clarify the observed associations. A review of how sexual aggression has been measured and reported thus far in the literature could help clarify the literature on pornography use and its associations with forced sex. To further clarify the nature of the observed associations, studies should also control for baseline confounders, such as access to or the quality of sexual health knowledge received by adolescents. While we recommend further research to develop more reliable and robust measures of exposure and outcomes, we also recognize that this type of research on adolescents’ behavior presents ethical barriers. There is a high level of moral concern in society regarding the potentially harmful influence of pornography on adolescents, including among research participants. This concern is likely to translate into barriers to the approval and funding of research on this topic.</p>
      <p>Most studies in this review were not inclusive of adolescents who were sexuality or gender-diverse. It has also been reported that same-sex-attracted male adolescents use pornography to negotiate their sexual identity, learn about the mechanics of sex and performance, and define ideas of pain and pleasure [<xref ref-type="bibr" rid="ref63">63</xref>]. Another study found that sexuality diverse adolescents used social media to share sexual information [<xref ref-type="bibr" rid="ref64">64</xref>].  Hence, it is possible that pornography may have different associations with sexual behaviors in sexuality diverse adolescents than in cisgender heterosexual peers. We recommend studies on sexual behaviors and their relationship to pornography in sexuality and gender-diverse adolescents.</p>
      <p>Recent findings [<xref ref-type="bibr" rid="ref65">65</xref>] suggest that sexual attitudes mediate the relationship between pornography exposure and sexual behavior. Recent studies in the United States [<xref ref-type="bibr" rid="ref66">66</xref>] have found that adults use pornography as a source of sex information. In college students, studies suggest a mediating role of sexual education in the relationship between exposure to pornography and sexual behaviors [<xref ref-type="bibr" rid="ref67">67</xref>-<xref ref-type="bibr" rid="ref69">69</xref>]. It is possible that individuals are most strongly influenced by pornography when they have limited access to sex education. Therefore, supporting international guidelines [<xref ref-type="bibr" rid="ref70">70</xref>], we also recommend that sex education be school based, universal, comprehensive, accurate, evidence informed, and age appropriate.</p>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist (2020) for systematic review on adolescent (aged 10-19 years) use of pornography.</p>
        <media xlink:href="jmir_v25i1e43116_app1.docx" xlink:title="DOCX File , 32 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>PRISMA-S (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Literature Search Extension) checklist for systematic review on adolescent (aged 10-19 years) use of pornography.</p>
        <media xlink:href="jmir_v25i1e43116_app2.docx" xlink:title="DOCX File , 20 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Search strategies used for systematic literature search on adolescent (aged 10-19 years) use of pornography.</p>
        <media xlink:href="jmir_v25i1e43116_app3.docx" xlink:title="DOCX File , 15 KB"/>
      </supplementary-material>
      <supplementary-material id="app4">
        <label>Multimedia Appendix 4</label>
        <p>Summary, definition of exposure, and grading of quality of studies included in the present systematic review.</p>
        <media xlink:href="jmir_v25i1e43116_app4.docx" xlink:title="DOCX File , 38 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">PRISMA</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>We thank Ms Kanchana Ekanayake (Associate of the Australian Library and Information Association, AALIA, and Certified Professional, CP) for their assistance in developing the search strategy for this systematic review. This work was supported by a summer research scholarship (2020) from the Faculty of Medicine and Health at the University of Sydney. We also disclose that no protocol was prepared for this review. This review is registered in PROSPERO, the International Prospective Register of Systematic Reviews (CRD42021227390). All quality assessments and extracted data are available in the <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>. PP was supported by a Research Training Program Scholarship at the University of Sydney. JLM was supported by the Australian National Health and Medical Research Council (grant numbers 1161445 and 1134894). ML was supported by the National Health and Medical Research Council (NHMRC) Career Development Fellowship.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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          <access-date>2022-10-22</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://unesdoc.unesco.org/ark:/48223/pf0000260770">https://unesdoc.unesco.org/ark:/48223/pf0000260770</ext-link>
          </comment>
        </nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
