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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v25i1e36964</article-id>
      <article-id pub-id-type="pmid">36729571</article-id>
      <article-id pub-id-type="doi">10.2196/36964</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>The Empowering Role of Web-Based Help Seeking on Depressive Symptoms: Systematic Review and Meta-analysis</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Kukafka</surname>
            <given-names>Rita</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Tannoubi</surname>
            <given-names>Amayra</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Coe</surname>
            <given-names>Amy</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>AL-Asadi</surname>
            <given-names>Ali</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author">
          <name name-style="western">
            <surname>Bizzotto</surname>
            <given-names>Nicole</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-4730-1367</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Marciano</surname>
            <given-names>Laura</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-8034-3227</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>de Bruijn</surname>
            <given-names>Gert-Jan</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-9759-3938</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Schulz</surname>
            <given-names>Peter Johannes</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Università della Svizzera italiana</institution>
            <addr-line>Via Buffi 13</addr-line>
            <addr-line>Lugano, 6900</addr-line>
            <country>Switzerland</country>
            <phone>41 58 666 4724</phone>
            <email>peter.schulz@usi.ch</email>
          </address>
          <xref rid="aff4" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-4281-489X</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Università della Svizzera italiana</institution>
        <addr-line>Lugano</addr-line>
        <country>Switzerland</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Harvard T H Chan School of Public Health and Dana-Farber Cancer Institute</institution>
        <addr-line>Boston, MA</addr-line>
        <country>United States</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>Department of Communication Studies</institution>
        <institution>Universiteit Antwerpen</institution>
        <addr-line>Antwerpen</addr-line>
        <country>Belgium</country>
      </aff>
      <aff id="aff4">
        <label>4</label>
        <institution>Department of Communication &#38; Media</institution>
        <institution>Ewha Womans University</institution>
        <addr-line>Seoul</addr-line>
        <country>Republic of Korea</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Peter Johannes Schulz <email>peter.schulz@usi.ch</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2023</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>2</day>
        <month>2</month>
        <year>2023</year>
      </pub-date>
      <volume>25</volume>
      <elocation-id>e36964</elocation-id>
      <history>
        <date date-type="received">
          <day>16</day>
          <month>5</month>
          <year>2022</year>
        </date>
        <date date-type="rev-request">
          <day>11</day>
          <month>9</month>
          <year>2022</year>
        </date>
        <date date-type="rev-recd">
          <day>16</day>
          <month>11</month>
          <year>2022</year>
        </date>
        <date date-type="accepted">
          <day>30</day>
          <month>11</month>
          <year>2022</year>
        </date>
      </history>
      <copyright-statement>©Nicole Bizzotto, Laura Marciano, Gert-Jan de Bruijn, Peter Johannes Schulz. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 02.02.2023.</copyright-statement>
      <copyright-year>2023</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://www.jmir.org/2023/1/e36964" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>Most research on web-based help seeking for mental health problems has focused on the antecedents of this behavior. Therefore, little is known about the outcomes of web-based help seeking in general or in specific mental health issues.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This study was a systematic review and meta-analysis of the literature on the antecedents and consequences of web-based help-seeking behaviors for depressive symptoms.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>A systematic literature search was carried out in 6 scientific databases, leading to 48 studies (for a total of 314,921 participants) included in the qualitative synthesis and 19 included in the meta-analysis.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>The results indicated a positive relationship between depressive symptoms and web-based help-seeking behaviors through online support groups (<italic>r</italic>=0.089; <italic>P</italic>=.009), and Generation Z (<italic>r</italic>=0.102; <italic>P</italic>=.008) tended to participate in support groups more than previous generations. In addition, web-based help seeking was positively related to empowerment (<italic>r</italic>=0.245; <italic>P</italic>=.004). Other forms of support reported included the internet and specific self-help tools, but no significant relationships were found with depressive symptoms.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>More studies examining the outcomes are needed, together with a more rigorous assessment of web-based help-seeking behaviors. Ultimately, we propose a summary framework for the literature on this topic, including the antecedents, patterns of use, and outcomes of web-based help seeking in the context of depressive symptoms.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>web-based help-seeking</kwd>
        <kwd>support groups</kwd>
        <kwd>depressive symptoms</kwd>
        <kwd>internet</kwd>
        <kwd>mental health</kwd>
        <kwd>empowerment</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>According to the World Health Organization [<xref ref-type="bibr" rid="ref1">1</xref>], more than 200 million people worldwide report having depressive symptoms annually. However, despite the availability of different treatments, the treatment gap (ie, the difference between the number of people who need care and those who receive care) is 72%-93% [<xref ref-type="bibr" rid="ref2">2</xref>]. Reasons are attributable to perceived stigma, poor mental health literacy, and negative attitudes toward seeking professionals [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>].</p>
        <p>As studies have demonstrated that different illnesses lead to distinctive patterns of web-based help seeking, it is crucial to examine the web-based behavior of individuals seeking help for specific illnesses such as depression [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>]. In particular, chronic patients increasingly seek web-based help to self-manage their conditions [<xref ref-type="bibr" rid="ref7">7</xref>-<xref ref-type="bibr" rid="ref10">10</xref>], and, as in the case of depressive symptomatology, they prefer to discuss their illness with others with the same disease [<xref ref-type="bibr" rid="ref11">11</xref>].</p>
        <p>The ability to connect with others anonymously is an essential feature of online support groups, which enables them to overcome their fear of stigmatization [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref13">13</xref>]. The latter is particularly important in the context of mental health, as it is a notable barrier to seeking formal aid [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. In addition, when compared with other mental health problems, people with depressive symptoms have different beliefs about their illness, resulting in diverse help-seeking trajectories, including long delays between the onset of symptoms and seeking help [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref15">15</xref>]. Notably, information gathering, social support, and empowerment in patients’ coping with depressive symptoms are important aspects to consider [<xref ref-type="bibr" rid="ref16">16</xref>]. These were key aspects before the internet revolution of peer-to-peer support groups, but presumably, their accessibility and importance have changed since then.</p>
        <p>In this review and meta-analysis, we aimed to systematically search and summarize the scientific literature on web-based help seeking and depressive symptoms and determine how web-based help-seeking behaviors are carried out in people with depressive symptomatology by considering both the antecedents and consequences of such behavior. On the basis of these findings, we propose an integrated framework that may help overcome the limitations of previous reviews on this topic.</p>
      </sec>
      <sec>
        <title>Depressive Symptoms and Web-Based Help Seeking</title>
        <p>The search for web-based health information and support has become increasingly frequent. In 2020, 7 out of 10 Americans [<xref ref-type="bibr" rid="ref17">17</xref>] obtained health-related information from the internet, and almost two-thirds of health consumers in the United States sought information on social media [<xref ref-type="bibr" rid="ref18">18</xref>]. Similar estimates were found in Europe [<xref ref-type="bibr" rid="ref19">19</xref>], where over half of those aged 16 to 74 years sought web-based help. The high accessibility, immediacy, and interactiveness generated by digital platforms are some of the reasons for the high prevalence of such behavior [<xref ref-type="bibr" rid="ref20">20</xref>]. Mental health disorders are a crucial public health issue, with prevalence rates of depressive and anxiety symptoms steadily increasing. People with depressive symptoms are likely to seek health information on the internet [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref22">22</xref>]. However, investigating how has been challenging owing to the large variability of web-based information and behaviors [<xref ref-type="bibr" rid="ref23">23</xref>-<xref ref-type="bibr" rid="ref25">25</xref>]. On the one hand, people with depressive symptoms search for web-based help to become better informed about how to manage their health conditions [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref26">26</xref>-<xref ref-type="bibr" rid="ref30">30</xref>]; however, web-based help seeking is not limited to seeking practical advice (ie, health information seeking) but also includes the emotional support that other users may solicit and provide, such as in online support groups [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>]. One can actively or passively participate in online support groups, thus affecting depression levels. For example, people who lurk (ie, observe rather than participate [<xref ref-type="bibr" rid="ref33">33</xref>]) are less likely to accrue benefits (eg, feel empowered) than those who actively participate. However, lurkers constitute a substantial proportion of online support groups, with estimates ranging from 45.5% to 90% [<xref ref-type="bibr" rid="ref34">34</xref>]. In addition, active web-based interactions with others may not only help alleviate [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref36">36</xref>] but also worsen symptoms of depression owing to exposure to others’ negative emotions and corumination [<xref ref-type="bibr" rid="ref37">37</xref>]. However, there is conflicting evidence on the extent to which people with depressive symptoms use web-based help-seeking services such as online support groups, how they use them (lurking vs posting activities), and the outcomes of such behavior.</p>
        <p>Because it is difficult to distinguish between these 2 highly intertwined behaviors—information exchange and emotional support [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref39">39</xref>]—we will use the term “web-based help-seeking” throughout the manuscript to refer to both health information and emotional support seeking.</p>
      </sec>
      <sec>
        <title>Outcomes of Web-Based Help Seeking</title>
        <p>Few studies have explored the outcomes of web-based help seeking in the context of general health [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>]. For example, in a recent systematic review, Smailhodzic et al [<xref ref-type="bibr" rid="ref42">42</xref>] found that social media use fostered equal communication between patients and health care professionals and empowered patients through improved disease management and control. Patient empowerment can be defined as the “feelings of power, control, and self-esteem that lead the patient to value autonomy—and thus interest in and desire to participate in healthcare decisions” [<xref ref-type="bibr" rid="ref43">43</xref>]. Schulz and Nakamoto [<xref ref-type="bibr" rid="ref43">43</xref>] applied the following four constructs (originally from Spreitzer [<xref ref-type="bibr" rid="ref44">44</xref>]) to the context of health: (1) “Meaningfulness” refers to the experience that what a person is doing is meaningful for their health; (2) “Self-efficacy” is the belief in one’s capabilities to produce the desired results by one’s actions; (3) “Self-determination” refers to a decision that is characterized by an autonomous initiation; and (4) “Impact” is the difference that the accomplishment of a task is perceived to make in the scheme of things. Few studies have examined empowerment within the context of web-based help seeking [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref46">46</xref>]. In particular, in online support groups, individuals can empower each other by exchanging information, encountering emotional support, finding recognition, and helping others [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref47">47</xref>]. Opportunities for empowering people who seek web-based help for their mental health symptoms remain an object of research. In particular, the extent to which people with depressive symptoms feel empowered by web-based help seeking remains an open question.</p>
      </sec>
      <sec>
        <title>Previous Reviews on Depressive Symptoms and Web-Based Help Seeking</title>
        <p>Previous systematic reviews have focused on the antecedents of web-based help-seeking behaviors as well as the different characteristics of web-based health channels [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref51">51</xref>]. Two recent systematic reviews and meta-analyses [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref51">51</xref>] found that contextual information (eg, quality and trust) of web-based information predicted web-based help-seeking behaviors better than other types of information (eg, attitudes toward seeking, perceived knowledge, and health literacy). However, these reviews investigated web-based help seeking in the context of general mental health problems, and no up-to-date reviews exist on web-based help seeking and depressive symptoms [<xref ref-type="bibr" rid="ref52">52</xref>]. In particular, systematic reviews on web-based help seeking and depressive symptoms are outdated because they refer to online support groups [<xref ref-type="bibr" rid="ref53">53</xref>-<xref ref-type="bibr" rid="ref56">56</xref>] without considering the rapid growth of social media–based communication and support [<xref ref-type="bibr" rid="ref57">57</xref>]. Online support groups and social media platforms may differ in terms of anonymity, participation rates, and social network opportunities. Furthermore, randomized controlled trials of web-based interventions, such as cognitive behavioral therapy [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref58">58</xref>], failed to capture the natural phenomenon of web-based help seeking outside the purpose of an intervention. In addition, previous systematic reviews reported inconsistent findings related to the benefits of social media use and social networking interventions in young people with depressive symptoms [<xref ref-type="bibr" rid="ref59">59</xref>]. Indeed, differences may emerge among different generational cohorts because of the development of the digital landscape, with younger generations being more technologically savvy [<xref ref-type="bibr" rid="ref60">60</xref>]. In this regard, younger generations have integrated technology into almost all areas of their lives, including web-based help-seeking behavior for mental health problems [<xref ref-type="bibr" rid="ref61">61</xref>].</p>
      </sec>
      <sec>
        <title>Study Aim</title>
        <p>In this review and meta-analysis, we aimed to systematically search and summarize the scientific literature on web-based help seeking and depressive symptoms and determine how web-based help-seeking behaviors are carried out in people with depressive symptomatology by considering both the antecedents and consequences of such behavior. On the basis of these findings, we propose an integrated framework that may help overcome the limitations of previous reviews on this topic.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <p>This systematic review was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement [<xref ref-type="bibr" rid="ref62">62</xref>]. The protocol was registered in PROSPERO (CRD42021250177).</p>
      <sec>
        <title>Search Strategy, Study Selection, and Data Extraction</title>
        <p>A systematic literature search was carried out from their inception in 6 electronic databases (September 14, 2022): PsycINFO, MEDLINE, Embase (via Ovid), CINAHL, Communication &#38; Mass Media Complete (via Ebscohost), and Web of Science (Clarivate Analytics) using key terms such as “depress*” OR “mood disord*” AND “help-seeking behavior” OR “information seeking” AND different types of study design like “surveys OR cross-sectional OR cohort*.” We did not restrict the search to a specific age range of participants. The detailed search strategy and keywords used are presented in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>. Finally, in October 2022, a manual search was conducted of the reference lists of the included studies in Google Scholar (limited to the first 100 entries for different combinations of keywords used in the other databases).</p>
        <p>We imported all entries in Zotero to automatically remove any duplicates. The first author and another coder (a Master student in Psychology and Health Communication) independently completed the title and abstract screening using Rayyan software [<xref ref-type="bibr" rid="ref63">63</xref>]. To obtain a measure of interrater reliability, we calculated Cohen κ statistic to screen titles and abstracts (Cohen κ=0.84). Disagreements (n=34) were resolved through a consensus meeting with a third researcher (LM). To be included in this phase, a study had to meet the following eligibility criteria: (1) include a measure of depressive symptoms, (2) include a measure of web-based help-seeking behavior (such as website consultation or online support groups), and (3) report a measure of the association between depressive symptoms and web-based help-seeking behaviors. In addition, in the case of compound scales for mental health symptoms, articles were included solely if they reported a score on the depression subscale.</p>
        <p>Studies reporting information on internet depression therapy, telephone depression counseling, or internet use outside health-related depression purposes were excluded. Studies were also excluded when their research methods were consistent in experiments, systematic reviews, or content analyses, or if they included a population with neurological disorders or inpatients. The latter limits clinical heterogeneity in participants. The first author then continued the full-text screening.</p>
        <p>The following information was extracted from the included studies (list of included studies in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref> [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref64">64</xref>-<xref ref-type="bibr" rid="ref108">108</xref>]): study design and methodology, the country where the study was conducted, sample size, sex (% male), the average age of participants, type of recruitment (web-based vs other), depressive symptoms measure, the type of web-based help-seeking behavior (“online support group” vs “internet in general” vs “specific applications”), and key findings. Furthermore, to analyze changes over time, studies were classified according to generational cohorts [<xref ref-type="bibr" rid="ref109">109</xref>] comprising Boomers I (born 1946-1954), Boomers II (1955-1964), Gen X (1965-1980), Gen Y or Millennials (1981-1996), and Gen Z (1997-2012). The detailed characteristics of all included studies are available in <xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref>. A summary of the extracted variables is presented in <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>. Data were reported in an MS Excel spreadsheet compiled by the first author and checked by LM. Missing data were handled by contacting the researchers for unreported data or additional details. In longitudinal studies, only the baseline information was extracted.</p>
      </sec>
      <sec>
        <title>Methodological Quality Assessment</title>
        <p>To assess the methodological quality of each study, we used an adapted version of the Strengthening the Reporting of Observational studies in Epidemiology (STROBE) checklist [<xref ref-type="bibr" rid="ref110">110</xref>]. In addition to the STROBE criteria, the following criteria were evaluated: (1) depressive symptom operationalization (0=self-reported diagnosis, 1=cutoff score on a depression rating scale, 2=diagnostic interview); (2) the presence of a reliability check for multiple-item measures of depression (1=present, 0=absent, NA=not applicable owing to single-item measures or clinical interviews); and (3) sampling strategy (1=random, 0=convenience). More information on the quality assessment of the studies can be found in <xref ref-type="supplementary-material" rid="app5">Multimedia Appendix 5</xref>.</p>
      </sec>
      <sec>
        <title>Meta-analysis</title>
        <p>Meta-analytic syntheses were carried out only for studies that included raw data convertible into effect sizes and similar concepts. The “meta” [<xref ref-type="bibr" rid="ref111">111</xref>] package in R (R Foundation for Statistical Computing) statistical software was used for the meta-analysis. The Fisher r-to-z transformation was calculated as a measure of effect size, and the results were converted back to r correlation coefficients for interpretation. Conversion formulas and “esc” package [<xref ref-type="bibr" rid="ref112">112</xref>,<xref ref-type="bibr" rid="ref113">113</xref>] were used when necessary to convert raw data to correlations. Meta-analyses were performed to link depressive symptoms with online support group use, internet use in general, and self-help tools as primary outcomes. We also included the following two outcomes: (1) empowerment of the person and (2) type of formal service used after using the abovementioned web-based services as secondary outcomes. We interpreted pooled effect sizes of <italic>r</italic>&#60;0.10, 0.10&#60;<italic>r</italic>&#60;0.50, and <italic>r</italic>&#62;0.50 as small, medium, and large, respectively [<xref ref-type="bibr" rid="ref114">114</xref>]. An inverse-variance method with a random-effects model and Hartung-Knapp-Sidik-Jonkman adjustment [<xref ref-type="bibr" rid="ref114">114</xref>] were used to adjust for study differences in sample sizes. The heterogeneity of results was calculated using the between-study variance <italic>τ</italic><sup>2</sup>, with the restricted maximum-likelihood estimator, and reported as the <italic>I</italic><sup>2</sup> statistic [<xref ref-type="bibr" rid="ref112">112</xref>,<xref ref-type="bibr" rid="ref115">115</xref>,<xref ref-type="bibr" rid="ref116">116</xref>]. We interpreted the <italic>I</italic><sup>2</sup> level as low (25%), moderate (50%), and high (75%) [<xref ref-type="bibr" rid="ref115">115</xref>]. When possible, additional meta-regression and subgroup analyses were carried out to investigate the role of moderators, such as generational cohort and sex of participants. Funnel plots and the Egger linear regression tests for funnel plot asymmetry were computed (when <italic>k</italic>≥10) to assess the presence of publication bias. Because of the paucity of studies investigating Generation Z, the article by Toscos [<xref ref-type="bibr" rid="ref64">64</xref>] was grouped with the millennials category.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Main Study Characteristics</title>
        <p>As shown in the PRISMA flowchart (<xref rid="figure1" ref-type="fig">Figure 1</xref>), the database search resulted in 3109 publications, including 1282 duplicates. Following title and abstract screening, 141 full texts were screened for eligibility, resulting in 48 included studies. In addition, at the beginning of September 2022, a manual search was carried out in Google Scholar, looking at the first 100 entries, resulting in 6 other added articles. A total of 48 studies were included in the qualitative synthesis and 19 were included in the meta-analysis. The retained studies were published in 37 different journals between 2002 and 2022.</p>
        <p>Before presenting the results of the studies, we acknowledge that they may be highly fragmentary owing to their heterogeneity. Hence, we have organized the description of the results as follows: the first part focuses on the descriptive characteristics of the included studies and the measures used for depressive symptoms. Then, the results will present the characteristics of web-based help seeking in terms of antecedents, patterns, and outcomes of behavior. Meta-analytic results will be reported following the related qualitative section.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart.</p>
          </caption>
          <graphic xlink:href="jmir_v25i1e36964_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Methodological Quality Assessment</title>
        <p>The articles’ quality scores ranged from 10 to 14 points (out of 15) based on the available study information (according to the STROBE checklist [<xref ref-type="bibr" rid="ref110">110</xref>]). In particular, only 19% (9/48) of studies reported having applied a random sampling strategy. In addition, the number of items for multi-item indicators of depressive symptoms ranged from 2 to 20, and scale reliability, assessed with α, was reported in 17 studies (range .72&#60;α&#60;.94). Many (38/48, 79%) studies adopted a cross-sectional design, whereas only 21% (10/48) of studies used a longitudinal design. Most of the studies were conducted in Western countries, particularly Europe (14/48, 29%) and North America (16/48, 33%).</p>
        <p>The analytical sample size varied greatly, with a median of 434.5, ranging from 32 [<xref ref-type="bibr" rid="ref65">65</xref>, <xref ref-type="bibr" rid="ref66">66</xref>] to 264,431 participants [<xref ref-type="bibr" rid="ref66">66</xref>]. On average, the mean percentage of male participants was 36.6%, which was calculated by excluding studies that looked specifically at the web-based help-seeking behavior of a specific population (eg, postpartum depression, adolescent girls, and patients with prostate cancer). The participants’ mean age was 37.03 years, ranging from 11 to 65 years. Studies predominantly investigated younger generations (Gen X, Y, Z; 33/48, 69%) rather than older generations (Boomers I and II; 14/48, 29%). Overall, 62% (30/48) of studies involved community-based adult samples, 21% (10/48) addressed caregivers or parents, and 12% (6/48) addressed patients with cancer.</p>
      </sec>
      <sec>
        <title>Overview of Web-Based Help Seeking and Depressive Symptoms</title>
        <p>In line with previous research in the field [<xref ref-type="bibr" rid="ref51">51</xref>], we distinguished different antecedents of web-based help seeking, such as psychological and instrumental factors. Psychological factors included intentions, attitudes, and beliefs. Intentions were assessed in 5 studies [<xref ref-type="bibr" rid="ref67">67</xref>-<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref117">117</xref>], stating that up to half of the respondents were generally willing to join online support groups [<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref68">68</xref>] and that participants with higher depression scores were substantially more likely to express willingness to use web-based chat sites and self-help resources [<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]. Concerning attitudes and beliefs toward web-based help seeking, 8 studies specifically addressed preferences in terms of comparison with offline help seeking—formal or informal—and showed that participants preferred face-to-face interventions over digital ones [<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref73">73</xref>], although 1 study [<xref ref-type="bibr" rid="ref73">73</xref>] found that internet-based information resources were the preferred support of Australian fathers. Furthermore, Leech et al [<xref ref-type="bibr" rid="ref74">74</xref>] reported that male participants were more likely to seek web-based help. Gold et al [<xref ref-type="bibr" rid="ref75">75</xref>] investigated differences in preferences among women participating in face-to-face versus online support groups. In total, 80% (47/60) of women in the face-to-face group, compared with only 31.2% (130/416) in the online support groups, agreed or strongly agreed that they would prefer to talk with someone in person than over the internet. Two studies [<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref119">119</xref>] reported that web-based help seeking was a common way to avoid the stigma associated with mental illness. In addition, attitudes toward self-reliance, defined as the tendency to make decisions by themselves, have been reported as barriers to web-based help seeking [<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref77">77</xref>].</p>
        <p>Instrumental factors relate to the utility, trustworthiness, and credibility of web-based help-seeking resources and information. These were assessed in 15 studies, including measures of perceived usefulness or satisfaction with the message board. In 8 studies, participants trusted web-based information [<xref ref-type="bibr" rid="ref21">21</xref>], which was judged as beneficial to manage their illness and allowed them to discuss the topic of depression more freely [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref79">79</xref>-<xref ref-type="bibr" rid="ref83">83</xref>]. In addition, in a WeChat professionally facilitated support group, community management was considered good or very good [<xref ref-type="bibr" rid="ref84">84</xref>]. Only in 1 study about multiple sclerosis, the reliability of website information was considered problematic according to the participants [<xref ref-type="bibr" rid="ref85">85</xref>].</p>
        <p>Interestingly, participants found relief not only in learning that they were not alone or “going crazy” [<xref ref-type="bibr" rid="ref75">75</xref>] but also in knowing that their struggle could help others [<xref ref-type="bibr" rid="ref86">86</xref>,<xref ref-type="bibr" rid="ref91">91</xref>]. In only 1 study [<xref ref-type="bibr" rid="ref118">118</xref>] that focused on mental health apps, participants expressed concerns about the accuracy and trustworthiness of the information reported in the app.</p>
      </sec>
      <sec>
        <title>Web-Based Help-Seeking Behaviors</title>
        <p>Our findings showed that people use different types of technology to support their mental health. Hence, web-based help-seeking behaviors were divided into (1) online support groups, (2) internet use in general, and (3) self-help tools.</p>
        <sec>
          <title>Online Support Groups</title>
          <p>Most (41/48, 85%) studies focused on using online support groups such as forums or bulletin boards—previously existing or created ad hoc for research purposes—through which people with depressive symptoms can discuss their issues with others and receive advice. Importantly, starting from 2013, with the work of Wright [<xref ref-type="bibr" rid="ref120">120</xref>], 23% (11/48) of studies investigated web-based communities present on social networking sites.</p>
          <p>Approximately half (19/41, 46%) of the studies addressed the use of online support groups in terms of “length and frequency of visits” and one-fourth (7/41, 17%) in terms of “duration of membership.” Two included studies reported that patients with depression were among the most frequent users of the internet for health information with respect to other chronic illnesses [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref80">80</xref>]. Furthermore, 3 studies showed that those with a greater need for help (ie, higher depression scores) reported a greater use of web-based resources and engagement [<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref120">120</xref>].</p>
          <p>The meta-analysis results showed that overall, the link between depressive symptoms and web-based help-seeking behaviors through online support groups was positive but very small, with considerable heterogeneity (<italic>k</italic>=14; <italic>r</italic>=0.089, 95% CI 0.026-0.151; <italic>P</italic>=.009; <italic>I</italic><sup>2</sup>=90%; <xref rid="figure2" ref-type="fig">Figure 2</xref>). Overall, less than 1% of help-seeking variation can be attributed to depression score variation. However, subgroup analyses showed significant differences in the effect size with respect to participants’ generations (<italic>P</italic>&#60;.001). Indeed, the effect size was not significant when studies included participants from Boomers I (<italic>k</italic>=2; <italic>r</italic>=0.016, 95% CI −0.176 to 0.207; <italic>P</italic>=.49; <italic>I</italic><sup>2</sup>=0%) and II (<italic>k</italic>=6; <italic>r</italic>=0.067, 95% CI −0.059 to 0.192; <italic>P</italic>=.23; <italic>I</italic><sup>2</sup>=94%). The effect was larger but still not significant for Generation Y or millennials (<italic>k</italic>=3; <italic>r</italic>=0.194, 95% CI −0.112 to 0.466; <italic>P</italic>=.11; <italic>I</italic><sup>2</sup>=86%) probably because of the high heterogeneity. The youngest participants, that is, Generation Z (<italic>k</italic>=3; <italic>r</italic>=0.102, 95% CI 0.062-0.142; <italic>P</italic>=.008; <italic>I</italic><sup>2</sup>=0%) reported a small, positive, and significant effect size, meaning that they more frequently searched for mental health information with respect to people of other generations. The funnel plot (<xref ref-type="supplementary-material" rid="app6">Multimedia Appendix 6</xref>) was symmetrical, and the results of the Egger test for funnel plot asymmetry were not significant (2-tailed <italic>t</italic> test, t<sub>12</sub>=−1.04; <italic>P</italic>=.32), thus indicating the absence of publication bias.</p>
          <fig id="figure2" position="float">
            <label>Figure 2</label>
            <caption>
              <p>Forest plot of the meta-analysis on online support group use and depressive symptoms.</p>
            </caption>
            <graphic xlink:href="jmir_v25i1e36964_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
        <sec>
          <title>General Internet Use</title>
          <p>A total of 17% (8/48) of studies assessed the general use of the internet in terms of website consultations [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref87">87</xref>,<xref ref-type="bibr" rid="ref88">88</xref>,<xref ref-type="bibr" rid="ref118">118</xref>,<xref ref-type="bibr" rid="ref129">129</xref>]. To address web-based help-seeking behavior, most (5/8, 62%) studies used a single-item measure, such as “Have you ever used internet for seeking health information?” [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref87">87</xref>,<xref ref-type="bibr" rid="ref88">88</xref>]. One study used a 5-point scale to investigate preferences for mental health support [<xref ref-type="bibr" rid="ref73">73</xref>], and another looked at the type of information searched (eg, symptoms, treatment, or suicide) [<xref ref-type="bibr" rid="ref65">65</xref>]. Findings in 1 study also mirror results from online support groups, that is, people with depressive symptoms were more likely to use the internet to find health information than people with other health conditions [<xref ref-type="bibr" rid="ref21">21</xref>]. However, the meta-analysis linking internet use in general and depressive symptoms included very few studies, and the effect size was not significant (<italic>k</italic>=4; <italic>r</italic>=0.313, 95% CI −0.233 to 0.709; <italic>P</italic>=.16; <italic>I</italic><sup>2</sup>=99%).</p>
        </sec>
        <sec>
          <title>Self-help Tools</title>
          <p>The last category included studies on self-help tools in terms of apps or websites, and 4 studies investigated this aspect [<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref118">118</xref>]. Three studies showed that participants with higher levels of depression also reported greater use of these apps and considered them to be more appealing [<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref87">87</xref>,<xref ref-type="bibr" rid="ref118">118</xref>]. The meta-analysis included only 2 studies and a nonsignificant effect size (<italic>k</italic>=2; <italic>r</italic>=0.041, 95% CI −0.208 to 0.286; <italic>P</italic>=.28; <italic>I</italic><sup>2</sup>=0%). Toscos et al [<xref ref-type="bibr" rid="ref70">70</xref>] found that students who participated in their survey were more interested in self-help apps than in other types of web-based help. The authors suggest that this is because of the features of these tools, which are capable of overcoming barriers such as stigma and hesitance to self-disclose.</p>
        </sec>
      </sec>
      <sec>
        <title>Outcomes</title>
        <p>The reported outcomes of web-based help seeking can be divided into the following: (1) changes in depressive symptomatology, (2) empowerment, and (3) formal service use<italic>.</italic> With respect to the former, 81% (34/48) of studies used self-report measures to assess depressive symptoms, whereas a few studies used diagnostic interviews (<xref ref-type="supplementary-material" rid="app7">Multimedia Appendix 7</xref>). The most common measure to assess depression was the Center for Epidemiologic Studies Depression Scale (17/48, 35%) in various versions, not only in the original version from 1997 [<xref ref-type="bibr" rid="ref89">89</xref>] (6/17, 35%) but also in the Iowa short form [<xref ref-type="bibr" rid="ref121">121</xref>] (6/17, 35%).</p>
        <p>Furthermore, results regarding changes in depressive symptomatology were inconsistent. In total, 4 studies found that engagement in web-based activities was not associated with a decrease in depressive symptoms [<xref ref-type="bibr" rid="ref90">90</xref>-<xref ref-type="bibr" rid="ref93">93</xref>]; whereas, others found that participants with higher levels of online support group participation had a greater resolution of their symptomatology [<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref93">93</xref>,<xref ref-type="bibr" rid="ref123">123</xref>,<xref ref-type="bibr" rid="ref124">124</xref>], sometimes indirectly through received and perceived social support or the experience of lower social isolation [<xref ref-type="bibr" rid="ref92">92</xref>,<xref ref-type="bibr" rid="ref124">124</xref>]. Only 1 study found that longer use time and session duration were associated with poorer depression outcomes [<xref ref-type="bibr" rid="ref95">95</xref>]. The diversity of results was supported by a longitudinal study [<xref ref-type="bibr" rid="ref80">80</xref>], which found that the positive effects of participating in online support groups were small for depressive symptoms. Similarly, in a study on WeChat [<xref ref-type="bibr" rid="ref71">71</xref>], the daily time spent showed no substantial relationship with health outcomes. Patient empowerment was classified according to Schulz and Nakamoto [<xref ref-type="bibr" rid="ref43">43</xref>] (<xref ref-type="supplementary-material" rid="app8">Multimedia Appendix 8</xref>). The most prevalent constructs addressed in the included studies were <italic>meaningfulness</italic> (n=12) and <italic>self-efficacy</italic> (n=9). The meaningfulness of web-based health information was operationalized as an additional “know how” and was related to a better understanding of the illness and treatment options [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref81">81</xref>-<xref ref-type="bibr" rid="ref84">84</xref>,<xref ref-type="bibr" rid="ref92">92</xref>,<xref ref-type="bibr" rid="ref97">97</xref>,<xref ref-type="bibr" rid="ref120">120</xref>], primarily resulting from the web-based social support offered by digital communities [<xref ref-type="bibr" rid="ref93">93</xref>,<xref ref-type="bibr" rid="ref98">98</xref>,<xref ref-type="bibr" rid="ref99">99</xref>]. In addition, self-efficacy was investigated in terms of a perceived enhanced ability to manage the illness and related symptoms [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref83">83</xref>-<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref92">92</xref>,<xref ref-type="bibr" rid="ref97">97</xref>,<xref ref-type="bibr" rid="ref120">120</xref>] or a better ability to discuss topics [<xref ref-type="bibr" rid="ref83">83</xref>]. Overall, web-based help seeking boosted the participants’ self-efficacy. However, Huber et al [<xref ref-type="bibr" rid="ref96">96</xref>] found that face-to-face support group members (vs online support group members) felt better prepared for a physician’s appointment. These results were confirmed by meta-analytic results that showed that in general, people with depressive symptoms felt empowered after engaging in web-based help-seeking behaviors. The meta-analysis, including 8 studies assessing the effects of web-based help seeking, showed a medium effect size (<italic>r</italic>=0.245, 95% CI 0.107-0.374; <italic>P</italic>=.004; <italic>I</italic><sup>2</sup>=96%; <xref rid="figure3" ref-type="fig">Figure 3</xref>). In addition, web-based help-seeking behaviors also influenced the relationship between patients and health care professionals and the patient’s propensity to seek formal services (psychotherapy or psychiatric treatment). Studies focused on patients and health care professionals [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref80">80</xref>-<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref91">91</xref>,<xref ref-type="bibr" rid="ref96">96</xref>] showed that using online support groups influences ongoing treatment [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref96">96</xref>] or exerted at least a minor impact on how participants communicated with their physician [<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref80">80</xref>], up to a point of delaying seeking professional help for a small percentage (52/604, 8.6%) of the participants [<xref ref-type="bibr" rid="ref83">83</xref>]. In contrast, 1 article [<xref ref-type="bibr" rid="ref123">123</xref>] reported that the use frequency of the web-based community was correlated only with help-seeking intentions from formal sources. According to the authors, as almost 88% (308/350) of the participants had been medicated for their mental health problems, users were making use of it to look for something other than (or in addition to) pharmacological interventions to help them deal with their mental health issues. However, a meta-analysis linking web-based help seeking and formal service use was not carried out because of the paucity of studies examining the 2 constructs.</p>
        <fig id="figure3" position="float">
          <label>Figure 3</label>
          <caption>
            <p>Forest plot of the meta-analysis on web-based help seeking and empowerment.</p>
          </caption>
          <graphic xlink:href="jmir_v25i1e36964_fig3.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>Studies of web-based help-seeking behaviors in the context of depressive symptoms have increased extensively in recent decades. However, an up-to-date review and meta-analysis of the link between these 2 concepts is still lacking. On the basis of 48 studies, this study reveals important findings, which can be summarized hereunder and will be discussed in detail in the following paragraph: (1) web-based communities on social networking sites are replacing forums during the last few years, and people with depressive symptoms tend to rely on web-based help more often than before; (2) users with depressive symptoms (and with more severe symptomatology) reported higher use of web-based resources; and (3) the current literature investigated this phenomenon in a highly heterogeneous manner, including antecedents (eg, psychological and instrumental), patterns of use (eg, online support groups, general internet use, and self-help tools), and outcomes (eg, empowerment and seeking medical help). In addition, although the results showed that people with depressive symptomatology feel more empowered when seeking web-based help, (4) more outcomes of such behavior (especially iatrogenic consequences) should be considered and investigated. Finally, to guide future research, we propose a summary framework that reports all the concepts included in an organized structure (<xref rid="figure4" ref-type="fig">Figure 4</xref>). The first result mirrors the evolution of networking sites (<xref rid="figure5" ref-type="fig">Figure 5</xref>). In particular, until the advent of the first social network sites, such as Facebook in 2004 and Twitter in 2006 [<xref ref-type="bibr" rid="ref99">99</xref>], online support groups found room on dedicated websites such as forums. Social networking sites have embedded online support groups in their features in various contexts related to health behavior or diseases, thus fostering participation rates and allowing access to online support groups at any time and location [<xref ref-type="bibr" rid="ref125">125</xref>,<xref ref-type="bibr" rid="ref126">126</xref>]. Note that social networking sites were not included in previous systematic reviews on the topic [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]. The meta-analysis results showed small positive effect sizes between depressive symptoms and web-based help-seeking behaviors, but the association was substantial only in the youngest generation, that is, Generation Z. Moreover, the qualitative summary provided evidence for the higher prevalence of people with depressive symptoms looking for information on the internet with respect to other chronic patients. This further stresses the importance of future studies on the investigation of web-based help seeking in young generations, which we proved are prone to managing their lives and health primarily on the internet. This is particularly relevant because new generations are heavy internet users [<xref ref-type="bibr" rid="ref127">127</xref>]. Furthermore, we found great heterogeneity in the studies’ results and methodologies, which we tried to summarize into conceptually comparable categories, including antecedents and patterns of use of online support groups, the internet, or specific self-help tools such as apps. Despite the most recent systematic review and meta-analysis, according to which contextual information plays a more crucial role than psychological information [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref51">51</xref>], studies have investigated both psychological and contextual factors as antecedents. Despite the participants’ preference for asking for help from formal services such as mental health professionals, they made more use of informal web-based services with respect to the other options. This is probably because of the possibility of overcoming geographic location and time constraints to connect (anonymously) with others with similar experiences [<xref ref-type="bibr" rid="ref128">128</xref>]. In addition, participation patterns play a role in health-related outcomes [<xref ref-type="bibr" rid="ref129">129</xref>-<xref ref-type="bibr" rid="ref131">131</xref>], where higher benefits were associated with posting (vs lurking) activities. Participants used online support groups to deal with depressive symptoms, as reported by the meta-analysis results. In addition, although the use of self-help tools such as mental health apps is a growing phenomenon [<xref ref-type="bibr" rid="ref132">132</xref>], few studies have examined this form of web-based help seeking. In particular, measures of web-based help-seeking behavior should be refined. Studies have assessed this concept very differently, with only some making use of validated scales (eg, the Intensity of Online Support Group Participation scale by Batenburg et al [<xref ref-type="bibr" rid="ref93">93</xref>]). Hence, future studies should rely on, and also develop, new measures of web-based help seeking by considering that this construct may cover both informational and socioemotional help simultaneously. As other authors noted earlier [<xref ref-type="bibr" rid="ref41">41</xref>], more consistent methods to measure web-based help-seeking behaviors are required. The limitations of self-reported measures should be overcome by using mixed method approaches to investigate the types of posts and activities carried out in online support groups to better disentangle clusters in the use of social networking sites and, at the same time, acknowledge the multidimensional nature of web-based help seeking [<xref ref-type="bibr" rid="ref120">120</xref>]. With respect to the outcomes, participants generally expressed that entering online support groups was beneficial and enhanced their mental health by promoting feelings of empowerment. Indeed, meta-analytic results showed that the link between empowerment and web-based help-seeking behaviors was positive and of medium size. This positive link is in line with previous systematic reviews that highlight the positive effects of web-based interventions on empowerment [<xref ref-type="bibr" rid="ref133">133</xref>]. In addition, a recent study by Johansson et al [<xref ref-type="bibr" rid="ref134">134</xref>] reported that participating in online support groups empowered patients to become more engaged and better contributed to the patient-provider relationship. However, the conceptualization of empowerment in these studies was vague; only 1 study explicitly mentioned empowerment [<xref ref-type="bibr" rid="ref81">81</xref>]. Hence, as suggested by Barr et al [<xref ref-type="bibr" rid="ref135">135</xref>], further work should develop a more appropriate measure to capture this construct, as it affects a broad range of health-related outcomes such as health status and medication adherence [<xref ref-type="bibr" rid="ref136">136</xref>,<xref ref-type="bibr" rid="ref137">137</xref>]. Measuring patient empowerment in people with depressive symptoms is crucial because it may influence self-stigma, one of the main barriers to seeking formal help [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref138">138</xref>]. In addition, more studies are needed to examine formal service use, a concept that has not been studied extensively. Owing to the scarcity of attention paid to this concept, it was not possible to make an informative summary in our study. However, empowerment is highly interconnected with formal service use and outcomes; empowerment not only increases self-management of chronic conditions but also influences the physician-patient relationship [<xref ref-type="bibr" rid="ref139">139</xref>]. In some cases, the results were contradictory. In 1 experiment, Audrain-Pontevia and Menvielle [<xref ref-type="bibr" rid="ref140">140</xref>] found that user empowerment was substantially but negatively related to user commitment to the physician. In contrast, McAllister et al [<xref ref-type="bibr" rid="ref141">141</xref>], found that empowerment promoted a more collaborative approach to health care. In particular, it needs to be clarified whether web-based resources act as gateways offering opportunities for improving access to therapy for people with mental health problems or whether online support groups are experienced as substitutes of formal services. In addition, other factors should be considered when studying empowerment, such as health literacy. According to the Health Empowerment Model, empowering processes may not always lead to better health-related outcomes in patients with low health literacy [<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref142">142</xref>]. Thus, we hypothesized that the positive or negative effects of web-based help-seeking behaviors may also depend on the level of health literacy. However, none of these studies assessed this variable. Ultimately, the proposed summary framework mirrors the categorization of variables reported in the included studies. As reported by previous theoretical models [<xref ref-type="bibr" rid="ref51">51</xref>], antecedents can be differentiated into psychological or instrumental factors. In particular, considering that there may be differences in terms of accessibility and participation between online support groups from the past (eg, forums) and new communities (eg, social networking sites), our model considers and differentiates a variety of channels and pays close attention to participation patterns by distinguishing, for example, active participation from lurking activities. In addition, the model emphasizes outcomes by differentiating between empowering processes and service use changes. Further research on this topic should consider the stage of participants’ trajectory with respect to their illness and whether web-based help seeking affects their attitudes toward mental health professionals and treatment options. Future research should evaluate other possible unintended consequences, such as the fostering of cyberchondria, defined as an excessive pattern of web-based health research associated with an increase in health anxiety [<xref ref-type="bibr" rid="ref143">143</xref>], a phenomenon frequently described in the context of the COVID-19 pandemic [<xref ref-type="bibr" rid="ref144">144</xref>].</p>
        <fig id="figure4" position="float">
          <label>Figure 4</label>
          <caption>
            <p>Proposed theoretical model.</p>
          </caption>
          <graphic xlink:href="jmir_v25i1e36964_fig4.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <fig id="figure5" position="float">
          <label>Figure 5</label>
          <caption>
            <p>Overview of the timeline of the included studies.</p>
          </caption>
          <graphic xlink:href="jmir_v25i1e36964_fig5.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <p>Gender differences should be considered when considering our model. For example, men may generally have higher levels of self-stigma, which, in turn, would affect their willingness to seek formal help [<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref145">145</xref>]. In previous reviews [<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref74">74</xref>], male participants were found to be more likely to seek informal support on the internet. This is arguably an important question that should be addressed in future research. In addition, further research is needed to explore the related implications of moving online support groups to social networking sites, especially considering the psychological and cognitive processes involved, as well as the antecedents and consequences. In addition, comorbidities should be controlled for specific psychopathological problems. Indeed, people with depressive symptoms often experience other psychopathological symptoms such as anxiety [<xref ref-type="bibr" rid="ref146">146</xref>].</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>The limitations identified in this systematic review are mainly related to the considerable heterogeneity in participants’ conditions and assessments of web-based help seeking, including its antecedents and consequences. In addition, most studies were conducted in Europe and North America, leaving out the results from Asian, African, and South American countries. The meta-analytic synthesis of the results was limited because of the heterogeneity of the studies. In addition, only a few studies, such as websites or self-help tools, have investigated channels other than online support groups. Therefore, meta-analyses and subgroup comparisons were not possible for the different types of web-based help-seeking communication. Eventually, most of the included studies lacked a theoretical background to guide the discussion of concepts of interest.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>In conclusion, as web-based help-seeking behavior in the context of depressive symptoms is an ever-growing phenomenon, especially in younger generations, high-quality research is needed to investigate the effects of such behaviors in terms of benefits and pitfalls. A more rigorous and coherent assessment of the construct of interest that considers antecedents, patterns of use, and consequences is also needed. In addition, it would be useful to consider how different social networking sites, platforms, and their features and affordances could influence web-based seeking behaviors.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>Search terms and strategy using Boolean operators.</p>
        <media xlink:href="jmir_v25i1e36964_app1.docx" xlink:title="DOCX File , 31 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Included studies.</p>
        <media xlink:href="jmir_v25i1e36964_app2.docx" xlink:title="DOCX File , 37 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Descriptive information of included articles.</p>
        <media xlink:href="jmir_v25i1e36964_app3.docx" xlink:title="DOCX File , 39 KB"/>
      </supplementary-material>
      <supplementary-material id="app4">
        <label>Multimedia Appendix 4</label>
        <p>Summary of variables in included articles.</p>
        <media xlink:href="jmir_v25i1e36964_app4.docx" xlink:title="DOCX File , 36 KB"/>
      </supplementary-material>
      <supplementary-material id="app5">
        <label>Multimedia Appendix 5</label>
        <p>Quality assessment of included articles.</p>
        <media xlink:href="jmir_v25i1e36964_app5.docx" xlink:title="DOCX File , 44 KB"/>
      </supplementary-material>
      <supplementary-material id="app6">
        <label>Multimedia Appendix 6</label>
        <p>Funnel plot.</p>
        <media xlink:href="jmir_v25i1e36964_app6.docx" xlink:title="DOCX File , 45 KB"/>
      </supplementary-material>
      <supplementary-material id="app7">
        <label>Multimedia Appendix 7</label>
        <p>Depression assessment.</p>
        <media xlink:href="jmir_v25i1e36964_app7.docx" xlink:title="DOCX File , 33 KB"/>
      </supplementary-material>
      <supplementary-material id="app8">
        <label>Multimedia Appendix 8</label>
        <p>Empowerment operationalization.</p>
        <media xlink:href="jmir_v25i1e36964_app8.docx" xlink:title="DOCX File , 36 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">PRISMA</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">STROBE</term>
          <def>
            <p>Strengthening the Reporting of Observational studies in Epidemiology</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This work was supported by the Swiss National Science Foundation under grants 200396 and P500PS_202974. The authors acknowledge the assistance of Stefano Giani (University of Amsterdam) in the systematic literature search. Authors also thank Jasmin Brummer for her help in the title and abstract screening.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <collab>World Health Organization</collab>
          </person-group>
          <source>Depression and other common mental disorders: global health estimates</source>
          <year>2017</year>
          <access-date>2022-05-16</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://apps.who.int/iris/handle/10665/254610">https://apps.who.int/iris/handle/10665/254610</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chisholm</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Sweeny</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Sheehan</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Rasmussen</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Smit</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Cuijpers</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Saxena</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Scaling-up treatment of depression and anxiety: a global return on investment analysis</article-title>
          <source>Lancet Psychiatry</source>
          <year>2016</year>
          <month>05</month>
          <volume>3</volume>
          <issue>5</issue>
          <fpage>415</fpage>
          <lpage>24</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://linkinghub.elsevier.com/retrieve/pii/S2215-0366(16)30024-4"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/S2215-0366(16)30024-4</pub-id>
          <pub-id pub-id-type="medline">27083119</pub-id>
          <pub-id pub-id-type="pii">S2215-0366(16)30024-4</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Gulliver</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Griffiths</surname>
              <given-names>KM</given-names>
            </name>
            <name name-style="western">
              <surname>Christensen</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>Perceived barriers and facilitators to mental health help-seeking in young people: a systematic review</article-title>
          <source>BMC Psychiatry</source>
          <year>2010</year>
          <month>12</month>
          <day>30</day>
          <volume>10</volume>
          <fpage>113</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcpsychiatry.biomedcentral.com/articles/10.1186/1471-244X-10-113"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/1471-244X-10-113</pub-id>
          <pub-id pub-id-type="medline">21192795</pub-id>
          <pub-id pub-id-type="pii">1471-244X-10-113</pub-id>
          <pub-id pub-id-type="pmcid">PMC3022639</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Rickwood</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Deane</surname>
              <given-names>FP</given-names>
            </name>
            <name name-style="western">
              <surname>Wilson</surname>
              <given-names>CJ</given-names>
            </name>
            <name name-style="western">
              <surname>Ciarrochi</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>Young people's help-seeking for mental health problems</article-title>
          <source>Aust E J Adv Ment Health</source>
          <year>2005</year>
          <month>12</month>
          <volume>4</volume>
          <issue>3</issue>
          <fpage>218</fpage>
          <lpage>51</lpage>
          <pub-id pub-id-type="doi">10.5172/jamh.4.3.218</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ou</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Ho</surname>
              <given-names>SS</given-names>
            </name>
          </person-group>
          <article-title>A meta-analysis of factors related to health information seeking: an integration from six theoretical frameworks</article-title>
          <source>Commun Res</source>
          <year>2021</year>
          <month>09</month>
          <day>11</day>
          <volume>49</volume>
          <issue>4</issue>
          <fpage>567</fpage>
          <lpage>93</lpage>
          <pub-id pub-id-type="doi">10.1177/00936502211043024</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Sedrak</surname>
              <given-names>MS</given-names>
            </name>
            <name name-style="western">
              <surname>Soto-Perez-De-Celis</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Nelson</surname>
              <given-names>RA</given-names>
            </name>
            <name name-style="western">
              <surname>Liu</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Waring</surname>
              <given-names>ME</given-names>
            </name>
            <name name-style="western">
              <surname>Lane</surname>
              <given-names>DS</given-names>
            </name>
            <name name-style="western">
              <surname>Paskett</surname>
              <given-names>ED</given-names>
            </name>
            <name name-style="western">
              <surname>Chlebowski</surname>
              <given-names>RT</given-names>
            </name>
          </person-group>
          <article-title>Online health information-seeking among older women with chronic illness: analysis of the women's health initiative</article-title>
          <source>J Med Internet Res</source>
          <year>2020</year>
          <month>04</month>
          <day>09</day>
          <volume>22</volume>
          <issue>4</issue>
          <fpage>e15906</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2020/4/e15906/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/15906</pub-id>
          <pub-id pub-id-type="medline">32271152</pub-id>
          <pub-id pub-id-type="pii">v22i4e15906</pub-id>
          <pub-id pub-id-type="pmcid">PMC7319595</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Barak</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Boniel-Nissim</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Suler</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>Fostering empowerment in online support groups</article-title>
          <source>Comput Human Behav</source>
          <year>2008</year>
          <month>09</month>
          <volume>24</volume>
          <issue>5</issue>
          <fpage>1867</fpage>
          <lpage>83</lpage>
          <pub-id pub-id-type="doi">10.1016/j.chb.2008.02.004</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Dwarswaard</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Bakker</surname>
              <given-names>EJ</given-names>
            </name>
            <name name-style="western">
              <surname>van Staa</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Boeije</surname>
              <given-names>HR</given-names>
            </name>
          </person-group>
          <article-title>Self-management support from the perspective of patients with a chronic condition: a thematic synthesis of qualitative studies</article-title>
          <source>Health Expect</source>
          <year>2016</year>
          <month>04</month>
          <volume>19</volume>
          <issue>2</issue>
          <fpage>194</fpage>
          <lpage>208</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/25619975"/>
          </comment>
          <pub-id pub-id-type="doi">10.1111/hex.12346</pub-id>
          <pub-id pub-id-type="medline">25619975</pub-id>
          <pub-id pub-id-type="pmcid">PMC5055271</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kingod</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Cleal</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Wahlberg</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Husted</surname>
              <given-names>GR</given-names>
            </name>
          </person-group>
          <article-title>Online peer-to-peer communities in the daily lives of people with chronic illness: a qualitative systematic review</article-title>
          <source>Qual Health Res</source>
          <year>2017</year>
          <month>01</month>
          <volume>27</volume>
          <issue>1</issue>
          <fpage>89</fpage>
          <lpage>99</lpage>
          <pub-id pub-id-type="doi">10.1177/1049732316680203</pub-id>
          <pub-id pub-id-type="medline">27956659</pub-id>
          <pub-id pub-id-type="pii">27/1/89</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Moorhead</surname>
              <given-names>SA</given-names>
            </name>
            <name name-style="western">
              <surname>Hazlett</surname>
              <given-names>DE</given-names>
            </name>
            <name name-style="western">
              <surname>Harrison</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Carroll</surname>
              <given-names>JK</given-names>
            </name>
            <name name-style="western">
              <surname>Irwin</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Hoving</surname>
              <given-names>C</given-names>
            </name>
          </person-group>
          <article-title>A new dimension of health care: systematic review of the uses, benefits, and limitations of social media for health communication</article-title>
          <source>J Med Internet Res</source>
          <year>2013</year>
          <month>04</month>
          <day>23</day>
          <volume>15</volume>
          <issue>4</issue>
          <fpage>e85</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2013/4/e85/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.1933</pub-id>
          <pub-id pub-id-type="medline">23615206</pub-id>
          <pub-id pub-id-type="pii">v15i4e85</pub-id>
          <pub-id pub-id-type="pmcid">PMC3636326</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lloyd-Evans</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Mayo-Wilson</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Harrison</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Istead</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Brown</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Pilling</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Johnson</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Kendall</surname>
              <given-names>T</given-names>
            </name>
          </person-group>
          <article-title>A systematic review and meta-analysis of randomised controlled trials of peer support for people with severe mental illness</article-title>
          <source>BMC Psychiatry</source>
          <year>2014</year>
          <month>03</month>
          <day>14</day>
          <volume>14</volume>
          <fpage>39</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcpsychiatry.biomedcentral.com/articles/10.1186/1471-244X-14-39"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/1471-244X-14-39</pub-id>
          <pub-id pub-id-type="medline">24528545</pub-id>
          <pub-id pub-id-type="pii">1471-244X-14-39</pub-id>
          <pub-id pub-id-type="pmcid">PMC3933205</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Naslund</surname>
              <given-names>JA</given-names>
            </name>
            <name name-style="western">
              <surname>Bondre</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Torous</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Aschbrenner</surname>
              <given-names>KA</given-names>
            </name>
          </person-group>
          <article-title>Social media and mental health: benefits, risks, and opportunities for research and practice</article-title>
          <source>J Technol Behav Sci</source>
          <year>2020</year>
          <month>09</month>
          <volume>5</volume>
          <issue>3</issue>
          <fpage>245</fpage>
          <lpage>57</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/33415185"/>
          </comment>
          <pub-id pub-id-type="doi">10.1007/s41347-020-00134-x</pub-id>
          <pub-id pub-id-type="medline">33415185</pub-id>
          <pub-id pub-id-type="pmcid">PMC7785056</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref13">
        <label>13</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Shalaby</surname>
              <given-names>RA</given-names>
            </name>
            <name name-style="western">
              <surname>Agyapong</surname>
              <given-names>VI</given-names>
            </name>
          </person-group>
          <article-title>Peer support in mental health: literature review</article-title>
          <source>JMIR Ment Health</source>
          <year>2020</year>
          <month>06</month>
          <day>09</day>
          <volume>7</volume>
          <issue>6</issue>
          <fpage>e15572</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://mental.jmir.org/2020/6/e15572/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/15572</pub-id>
          <pub-id pub-id-type="medline">32357127</pub-id>
          <pub-id pub-id-type="pii">v7i6e15572</pub-id>
          <pub-id pub-id-type="pmcid">PMC7312261</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref14">
        <label>14</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Moore</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Ayers</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Drey</surname>
              <given-names>N</given-names>
            </name>
          </person-group>
          <article-title>A thematic analysis of stigma and disclosure for perinatal depression on an online forum</article-title>
          <source>JMIR Ment Health</source>
          <year>2016</year>
          <month>05</month>
          <day>19</day>
          <volume>3</volume>
          <issue>2</issue>
          <fpage>e18</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://mental.jmir.org/2016/2/e18/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/mental.5611</pub-id>
          <pub-id pub-id-type="medline">27197516</pub-id>
          <pub-id pub-id-type="pii">v3i2e18</pub-id>
          <pub-id pub-id-type="pmcid">PMC4909386</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref15">
        <label>15</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Krendl</surname>
              <given-names>AC</given-names>
            </name>
            <name name-style="western">
              <surname>Freeman</surname>
              <given-names>JB</given-names>
            </name>
          </person-group>
          <article-title>Are mental illnesses stigmatized for the same reasons? Identifying the stigma-related beliefs underlying common mental illnesses</article-title>
          <source>J Ment Health</source>
          <year>2019</year>
          <month>06</month>
          <volume>28</volume>
          <issue>3</issue>
          <fpage>267</fpage>
          <lpage>75</lpage>
          <pub-id pub-id-type="doi">10.1080/09638237.2017.1385734</pub-id>
          <pub-id pub-id-type="medline">29020836</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref16">
        <label>16</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Crisp</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Griffiths</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Mackinnon</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Bennett</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Christensen</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>An online intervention for reducing depressive symptoms: secondary benefits for self-esteem, empowerment and quality of life</article-title>
          <source>Psychiatry Res</source>
          <year>2014</year>
          <month>04</month>
          <day>30</day>
          <volume>216</volume>
          <issue>1</issue>
          <fpage>60</fpage>
          <lpage>6</lpage>
          <pub-id pub-id-type="doi">10.1016/j.psychres.2014.01.041</pub-id>
          <pub-id pub-id-type="medline">24534125</pub-id>
          <pub-id pub-id-type="pii">S0165-1781(14)00082-1</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref17">
        <label>17</label>
        <nlm-citation citation-type="web">
          <article-title>The Great American Search for Healthcare Information</article-title>
          <source>Weber Shandwick</source>
          <access-date>2021-10-17</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.webershandwick.com/wp-content/uploads/2018/11/Healthcare-Info-Search-Report.pdf">https://www.webershandwick.com/wp-content/uploads/2018/11/Healthcare-Info-Search-Report.pdf</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref18">
        <label>18</label>
        <nlm-citation citation-type="web">
          <article-title>Social media and Health care by the numbers</article-title>
          <source>SMA (Southern Medical Association)</source>
          <access-date>2021-10-17</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://sma.org/social-media-healthcare-by-the-numbers/">https://sma.org/social-media-healthcare-by-the-numbers/</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref19">
        <label>19</label>
        <nlm-citation citation-type="web">
          <article-title>EU citizens: over half seek health information online</article-title>
          <source>eurostat</source>
          <access-date>2022-09-13</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://ec.europa.eu/eurostat/web/products-eurostat-news/-/edn-20220406-1">https://ec.europa.eu/eurostat/web/products-eurostat-news/-/edn-20220406-1</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref20">
        <label>20</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Morahan-Martin</surname>
              <given-names>JM</given-names>
            </name>
          </person-group>
          <article-title>How internet users find, evaluate, and use online health information: a cross-cultural review</article-title>
          <source>Cyberpsychol Behav</source>
          <year>2004</year>
          <month>10</month>
          <volume>7</volume>
          <issue>5</issue>
          <fpage>497</fpage>
          <lpage>510</lpage>
          <pub-id pub-id-type="doi">10.1089/cpb.2004.7.497</pub-id>
          <pub-id pub-id-type="medline">15667044</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref21">
        <label>21</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Wagner</surname>
              <given-names>TH</given-names>
            </name>
            <name name-style="western">
              <surname>Baker</surname>
              <given-names>LC</given-names>
            </name>
            <name name-style="western">
              <surname>Bundorf</surname>
              <given-names>MK</given-names>
            </name>
            <name name-style="western">
              <surname>Singer</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Use of the Internet for health information by the chronically ill</article-title>
          <source>Prev Chronic Dis</source>
          <year>2004</year>
          <month>10</month>
          <volume>1</volume>
          <issue>4</issue>
          <fpage>A13</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/15670445"/>
          </comment>
          <pub-id pub-id-type="medline">15670445</pub-id>
          <pub-id pub-id-type="pii">A13</pub-id>
          <pub-id pub-id-type="pmcid">PMC1277953</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref22">
        <label>22</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Brohan</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Gauci</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Sartorius</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Thornicroft</surname>
              <given-names>G</given-names>
            </name>
            <collab>GAMIAN-Europe Study Group</collab>
          </person-group>
          <article-title>Self-stigma, empowerment and perceived discrimination among people with bipolar disorder or depression in 13 European countries: the GAMIAN-Europe study</article-title>
          <source>J Affect Disord</source>
          <year>2011</year>
          <month>03</month>
          <volume>129</volume>
          <issue>1-3</issue>
          <fpage>56</fpage>
          <lpage>63</lpage>
          <pub-id pub-id-type="doi">10.1016/j.jad.2010.09.001</pub-id>
          <pub-id pub-id-type="medline">20888050</pub-id>
          <pub-id pub-id-type="pii">S0165-0327(10)00569-0</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref23">
        <label>23</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Fox</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Duggan</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Health Online 2013</article-title>
          <source>Pew Research Center</source>
          <year>2013</year>
          <month>1</month>
          <day>15</day>
          <access-date>2022-05-16</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.pewresearch.org/internet/2013/01/15/health-online-2013/">https://www.pewresearch.org/internet/2013/01/15/health-online-2013/</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref24">
        <label>24</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Sciamanna</surname>
              <given-names>CN</given-names>
            </name>
            <name name-style="western">
              <surname>Clark</surname>
              <given-names>MA</given-names>
            </name>
            <name name-style="western">
              <surname>Houston</surname>
              <given-names>TK</given-names>
            </name>
            <name name-style="western">
              <surname>Diaz</surname>
              <given-names>JA</given-names>
            </name>
          </person-group>
          <article-title>Unmet needs of primary care patients in using the Internet for health-related activities</article-title>
          <source>J Med Internet Res</source>
          <year>2002</year>
          <month>12</month>
          <volume>4</volume>
          <issue>3</issue>
          <fpage>E19</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2002/3/e19/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.4.3.e19</pub-id>
          <pub-id pub-id-type="medline">12554550</pub-id>
          <pub-id pub-id-type="pmcid">PMC1761942</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref25">
        <label>25</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Suzuki</surname>
              <given-names>LK</given-names>
            </name>
            <name name-style="western">
              <surname>Calzo</surname>
              <given-names>JP</given-names>
            </name>
          </person-group>
          <article-title>The search for peer advice in cyberspace: an examination of online teen bulletin boards about health and sexuality</article-title>
          <source>J App Dev Psychol</source>
          <year>2004</year>
          <month>11</month>
          <volume>25</volume>
          <issue>6</issue>
          <fpage>685</fpage>
          <lpage>98</lpage>
          <pub-id pub-id-type="doi">10.1016/j.appdev.2004.09.002</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref26">
        <label>26</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lindley</surname>
              <given-names>CK</given-names>
            </name>
          </person-group>
          <article-title>Information seeking and concern for mental well-being?</article-title>
          <source>Purdue University</source>
          <year>2015</year>
          <access-date>2022-05-16</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://docs.lib.purdue.edu/open_access_theses/474/">https://docs.lib.purdue.edu/open_access_theses/474/</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref27">
        <label>27</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Park</surname>
              <given-names>HA</given-names>
            </name>
          </person-group>
          <article-title>Development of a health information technology acceptance model using consumers' health behavior intention</article-title>
          <source>J Med Internet Res</source>
          <year>2012</year>
          <month>10</month>
          <day>01</day>
          <volume>14</volume>
          <issue>5</issue>
          <fpage>e133</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2012/5/e133/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.2143</pub-id>
          <pub-id pub-id-type="medline">23026508</pub-id>
          <pub-id pub-id-type="pii">v14i5e133</pub-id>
          <pub-id pub-id-type="pmcid">PMC3510715</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref28">
        <label>28</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lambert</surname>
              <given-names>SD</given-names>
            </name>
            <name name-style="western">
              <surname>Loiselle</surname>
              <given-names>CG</given-names>
            </name>
          </person-group>
          <article-title>Health information seeking behavior</article-title>
          <source>Qual Health Res</source>
          <year>2007</year>
          <month>10</month>
          <volume>17</volume>
          <issue>8</issue>
          <fpage>1006</fpage>
          <lpage>19</lpage>
          <pub-id pub-id-type="doi">10.1177/1049732307305199</pub-id>
          <pub-id pub-id-type="medline">17928475</pub-id>
          <pub-id pub-id-type="pii">17/8/1006</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref29">
        <label>29</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Niederdeppe</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Hornik</surname>
              <given-names>RC</given-names>
            </name>
            <name name-style="western">
              <surname>Kelly</surname>
              <given-names>BJ</given-names>
            </name>
            <name name-style="western">
              <surname>Frosch</surname>
              <given-names>DL</given-names>
            </name>
            <name name-style="western">
              <surname>Romantan</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Stevens</surname>
              <given-names>RS</given-names>
            </name>
            <name name-style="western">
              <surname>Barg</surname>
              <given-names>FK</given-names>
            </name>
            <name name-style="western">
              <surname>Weiner</surname>
              <given-names>JL</given-names>
            </name>
            <name name-style="western">
              <surname>Schwartz</surname>
              <given-names>JS</given-names>
            </name>
          </person-group>
          <article-title>Examining the dimensions of cancer-related information seeking and scanning behavior</article-title>
          <source>Health Commun</source>
          <year>2007</year>
          <volume>22</volume>
          <issue>2</issue>
          <fpage>153</fpage>
          <lpage>67</lpage>
          <pub-id pub-id-type="doi">10.1080/10410230701454189</pub-id>
          <pub-id pub-id-type="medline">17668995</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref30">
        <label>30</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Zimmerman</surname>
              <given-names>MS</given-names>
            </name>
            <name name-style="western">
              <surname>Shaw Jr</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Health information seeking behaviour: a concept analysis</article-title>
          <source>Health Info Libr J</source>
          <year>2020</year>
          <month>09</month>
          <volume>37</volume>
          <issue>3</issue>
          <fpage>173</fpage>
          <lpage>91</lpage>
          <pub-id pub-id-type="doi">10.1111/hir.12287</pub-id>
          <pub-id pub-id-type="medline">32052549</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref31">
        <label>31</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chang</surname>
              <given-names>HJ</given-names>
            </name>
          </person-group>
          <article-title>Online supportive interactions: using a network approach to examine communication patterns within a psychosis social support group in Taiwan</article-title>
          <source>J Am Soc Inf Sci</source>
          <year>2009</year>
          <month>07</month>
          <volume>60</volume>
          <issue>7</issue>
          <fpage>1504</fpage>
          <lpage>17</lpage>
          <pub-id pub-id-type="doi">10.1002/asi.21070</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref32">
        <label>32</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Gilmour</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Machin</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Brownlow</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Jeffries</surname>
              <given-names>C</given-names>
            </name>
          </person-group>
          <article-title>Facebook-based social support and health: a systematic review</article-title>
          <source>Psychol Pop Media</source>
          <year>2020</year>
          <month>07</month>
          <volume>9</volume>
          <issue>3</issue>
          <fpage>328</fpage>
          <lpage>46</lpage>
          <pub-id pub-id-type="doi">10.1037/ppm0000246</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref33">
        <label>33</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Edelmann</surname>
              <given-names>N</given-names>
            </name>
          </person-group>
          <article-title>Reviewing the definitions of "lurkers" and some implications for online research</article-title>
          <source>Cyberpsychol Behav Soc Netw</source>
          <year>2013</year>
          <month>09</month>
          <volume>16</volume>
          <issue>9</issue>
          <fpage>645</fpage>
          <lpage>9</lpage>
          <pub-id pub-id-type="doi">10.1089/cyber.2012.0362</pub-id>
          <pub-id pub-id-type="medline">23848960</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref34">
        <label>34</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Nonnecke</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Preece</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>Persistence and lurkers in discussion lists: a pilot study</article-title>
          <source>Proceedings of the 33rd Annual Hawaii International Conference on System Sciences</source>
          <year>2000</year>
          <conf-name>HICSS '00</conf-name>
          <conf-date>January 7, 2000</conf-date>
          <conf-loc>Maui, HI, USA</conf-loc>
          <fpage>10</fpage>
          <pub-id pub-id-type="doi">doi:10.1109/HICSS.2000.926714</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref35">
        <label>35</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Richards</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Richardson</surname>
              <given-names>T</given-names>
            </name>
          </person-group>
          <article-title>Computer-based psychological treatments for depression: a systematic review and meta-analysis</article-title>
          <source>Clin Psychol Rev</source>
          <year>2012</year>
          <month>06</month>
          <volume>32</volume>
          <issue>4</issue>
          <fpage>329</fpage>
          <lpage>42</lpage>
          <pub-id pub-id-type="doi">10.1016/j.cpr.2012.02.004</pub-id>
          <pub-id pub-id-type="medline">22466510</pub-id>
          <pub-id pub-id-type="pii">S0272-7358(12)00027-X</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref36">
        <label>36</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Taylor-Jackson</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Moustafa</surname>
              <given-names>AA</given-names>
            </name>
          </person-group>
          <person-group person-group-type="editor">
            <name name-style="western">
              <surname>Moustafa</surname>
              <given-names>AA</given-names>
            </name>
          </person-group>
          <article-title>The relationships between social media use and factors relating to depression</article-title>
          <source>The Nature of Depression: An Updated Review</source>
          <year>2021</year>
          <publisher-loc>Cambridge, MA, USA</publisher-loc>
          <publisher-name>Academic Press</publisher-name>
          <fpage>171</fpage>
          <lpage>82</lpage>
        </nlm-citation>
      </ref>
      <ref id="ref37">
        <label>37</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>van Uden-Kraan</surname>
              <given-names>CF</given-names>
            </name>
            <name name-style="western">
              <surname>Drossaert</surname>
              <given-names>CH</given-names>
            </name>
            <name name-style="western">
              <surname>Taal</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Shaw</surname>
              <given-names>BR</given-names>
            </name>
            <name name-style="western">
              <surname>Seydel</surname>
              <given-names>ER</given-names>
            </name>
            <name name-style="western">
              <surname>van de Laar</surname>
              <given-names>MA</given-names>
            </name>
          </person-group>
          <article-title>Empowering processes and outcomes of participation in online support groups for patients with breast cancer, arthritis, or fibromyalgia</article-title>
          <source>Qual Health Res</source>
          <year>2008</year>
          <month>03</month>
          <volume>18</volume>
          <issue>3</issue>
          <fpage>405</fpage>
          <lpage>17</lpage>
          <pub-id pub-id-type="doi">10.1177/1049732307313429</pub-id>
          <pub-id pub-id-type="medline">18235163</pub-id>
          <pub-id pub-id-type="pii">18/3/405</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref38">
        <label>38</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ekberg</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>McDermott</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Moynihan</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Brindle</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Little</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Leydon</surname>
              <given-names>GM</given-names>
            </name>
          </person-group>
          <article-title>The role of helplines in cancer care: intertwining emotional support with information or advice-seeking needs</article-title>
          <source>J Psychosoc Oncol</source>
          <year>2014</year>
          <volume>32</volume>
          <issue>3</issue>
          <fpage>359</fpage>
          <lpage>81</lpage>
          <pub-id pub-id-type="doi">10.1080/07347332.2014.897294</pub-id>
          <pub-id pub-id-type="medline">24611530</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref39">
        <label>39</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kowitt</surname>
              <given-names>SD</given-names>
            </name>
            <name name-style="western">
              <surname>Urlaub</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Guzman-Corrales</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Mayer</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Ballesteros</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Graffy</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Simmons</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Cummings</surname>
              <given-names>DM</given-names>
            </name>
            <name name-style="western">
              <surname>Fisher</surname>
              <given-names>EB</given-names>
            </name>
          </person-group>
          <article-title>Emotional support for diabetes management: an international cross-cultural study</article-title>
          <source>Diabetes Educ</source>
          <year>2015</year>
          <month>06</month>
          <volume>41</volume>
          <issue>3</issue>
          <fpage>291</fpage>
          <lpage>300</lpage>
          <pub-id pub-id-type="doi">10.1177/0145721715574729</pub-id>
          <pub-id pub-id-type="medline">25722064</pub-id>
          <pub-id pub-id-type="pii">0145721715574729</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref40">
        <label>40</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Giustini</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Ali</surname>
              <given-names>SM</given-names>
            </name>
            <name name-style="western">
              <surname>Fraser</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Kamel Boulos</surname>
              <given-names>MN</given-names>
            </name>
          </person-group>
          <article-title>Effective uses of social media in public health and medicine: a systematic review of systematic reviews</article-title>
          <source>Online J Public Health Inform</source>
          <year>2018</year>
          <month>9</month>
          <day>21</day>
          <volume>10</volume>
          <issue>2</issue>
          <fpage>e215</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/30349633"/>
          </comment>
          <pub-id pub-id-type="doi">10.5210/ojphi.v10i2.8270</pub-id>
          <pub-id pub-id-type="medline">30349633</pub-id>
          <pub-id pub-id-type="pii">ojphi-10-e215</pub-id>
          <pub-id pub-id-type="pmcid">PMC6194097</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref41">
        <label>41</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kauer</surname>
              <given-names>SD</given-names>
            </name>
            <name name-style="western">
              <surname>Mangan</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Sanci</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>Do online mental health services improve help-seeking for young people? A systematic review</article-title>
          <source>J Med Internet Res</source>
          <year>2014</year>
          <month>03</month>
          <day>04</day>
          <volume>16</volume>
          <issue>3</issue>
          <fpage>e66</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2014/3/e66/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.3103</pub-id>
          <pub-id pub-id-type="medline">24594922</pub-id>
          <pub-id pub-id-type="pii">v16i3e66</pub-id>
          <pub-id pub-id-type="pmcid">PMC3961801</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref42">
        <label>42</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Smailhodzic</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Hooijsma</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Boonstra</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Langley</surname>
              <given-names>DJ</given-names>
            </name>
          </person-group>
          <article-title>Social media use in healthcare: a systematic review of effects on patients and on their relationship with healthcare professionals</article-title>
          <source>BMC Health Serv Res</source>
          <year>2016</year>
          <month>08</month>
          <day>26</day>
          <volume>16</volume>
          <issue>1</issue>
          <fpage>442</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-016-1691-0"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/s12913-016-1691-0</pub-id>
          <pub-id pub-id-type="medline">27562728</pub-id>
          <pub-id pub-id-type="pii">10.1186/s12913-016-1691-0</pub-id>
          <pub-id pub-id-type="pmcid">PMC5000484</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref43">
        <label>43</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Schulz</surname>
              <given-names>PJ</given-names>
            </name>
            <name name-style="western">
              <surname>Nakamoto</surname>
              <given-names>K</given-names>
            </name>
          </person-group>
          <article-title>Health literacy and patient empowerment in health communication: the importance of separating conjoined twins</article-title>
          <source>Patient Educ Couns</source>
          <year>2013</year>
          <month>01</month>
          <volume>90</volume>
          <issue>1</issue>
          <fpage>4</fpage>
          <lpage>11</lpage>
          <pub-id pub-id-type="doi">10.1016/j.pec.2012.09.006</pub-id>
          <pub-id pub-id-type="medline">23063359</pub-id>
          <pub-id pub-id-type="pii">S0738-3991(12)00379-5</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref44">
        <label>44</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Spreitzer</surname>
              <given-names>GM</given-names>
            </name>
          </person-group>
          <article-title>Psychological empowerment in the workplace: dimensions, measurement, and validation</article-title>
          <source>Acad Manag J</source>
          <year>1995</year>
          <month>10</month>
          <day>01</day>
          <volume>38</volume>
          <issue>5</issue>
          <fpage>1442</fpage>
          <lpage>65</lpage>
          <pub-id pub-id-type="doi">10.2307/256865</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref45">
        <label>45</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Atanasova</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Petric</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Collective empowerment in online health communities: scale development and empirical validation</article-title>
          <source>J Med Internet Res</source>
          <year>2019</year>
          <month>11</month>
          <day>20</day>
          <volume>21</volume>
          <issue>11</issue>
          <fpage>e14392</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2019/11/e14392/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/14392</pub-id>
          <pub-id pub-id-type="medline">31746772</pub-id>
          <pub-id pub-id-type="pii">v21i11e14392</pub-id>
          <pub-id pub-id-type="pmcid">PMC6893566</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref46">
        <label>46</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Petrič</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Atanasova</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Kamin</surname>
              <given-names>T</given-names>
            </name>
          </person-group>
          <article-title>Impact of social processes in online health communities on patient empowerment in relationship with the physician: emergence of functional and dysfunctional empowerment</article-title>
          <source>J Med Internet Res</source>
          <year>2017</year>
          <month>03</month>
          <day>13</day>
          <volume>19</volume>
          <issue>3</issue>
          <fpage>e74</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2017/3/e74/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.7002</pub-id>
          <pub-id pub-id-type="medline">28288953</pub-id>
          <pub-id pub-id-type="pii">v19i3e74</pub-id>
          <pub-id pub-id-type="pmcid">PMC5368349</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref47">
        <label>47</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>van Uden-Kraan</surname>
              <given-names>CF</given-names>
            </name>
            <name name-style="western">
              <surname>Drossaert</surname>
              <given-names>CH</given-names>
            </name>
            <name name-style="western">
              <surname>Taal</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Seydel</surname>
              <given-names>ER</given-names>
            </name>
            <name name-style="western">
              <surname>van de Laar</surname>
              <given-names>MA</given-names>
            </name>
          </person-group>
          <article-title>Participation in online patient support groups endorses patients' empowerment</article-title>
          <source>Patient Educ Couns</source>
          <year>2009</year>
          <month>01</month>
          <volume>74</volume>
          <issue>1</issue>
          <fpage>61</fpage>
          <lpage>9</lpage>
          <pub-id pub-id-type="doi">10.1016/j.pec.2008.07.044</pub-id>
          <pub-id pub-id-type="medline">18778909</pub-id>
          <pub-id pub-id-type="pii">S0738-3991(08)00394-7</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref48">
        <label>48</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chang</surname>
              <given-names>CC</given-names>
            </name>
            <name name-style="western">
              <surname>Huang</surname>
              <given-names>MH</given-names>
            </name>
          </person-group>
          <article-title>Antecedents predicting health information seeking: a systematic review and meta-analysis</article-title>
          <source>Int J Inf Manag</source>
          <year>2020</year>
          <month>10</month>
          <volume>54</volume>
          <fpage>102115</fpage>
          <pub-id pub-id-type="doi">10.1016/j.ijinfomgt.2020.102115</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref49">
        <label>49</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kubb</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Foran</surname>
              <given-names>HM</given-names>
            </name>
          </person-group>
          <article-title>Online health information seeking by parents for their children: systematic review and agenda for further research</article-title>
          <source>J Med Internet Res</source>
          <year>2020</year>
          <month>08</month>
          <day>25</day>
          <volume>22</volume>
          <issue>8</issue>
          <fpage>e19985</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2020/8/e19985/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/19985</pub-id>
          <pub-id pub-id-type="medline">32840484</pub-id>
          <pub-id pub-id-type="pii">v22i8e19985</pub-id>
          <pub-id pub-id-type="pmcid">PMC7479585</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref50">
        <label>50</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Mirzaei</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Aslani</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Luca</surname>
              <given-names>EJ</given-names>
            </name>
            <name name-style="western">
              <surname>Schneider</surname>
              <given-names>CR</given-names>
            </name>
          </person-group>
          <article-title>Predictors of health information-seeking behavior: systematic literature review and network analysis</article-title>
          <source>J Med Internet Res</source>
          <year>2021</year>
          <month>07</month>
          <day>02</day>
          <volume>23</volume>
          <issue>7</issue>
          <fpage>e21680</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2021/7/e21680/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/21680</pub-id>
          <pub-id pub-id-type="medline">33979776</pub-id>
          <pub-id pub-id-type="pii">v23i7e21680</pub-id>
          <pub-id pub-id-type="pmcid">PMC8285748</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref51">
        <label>51</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Wang</surname>
              <given-names>X</given-names>
            </name>
            <name name-style="western">
              <surname>Shi</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Kong</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>Online health information seeking: a review and meta-analysis</article-title>
          <source>Health Commun</source>
          <year>2021</year>
          <month>09</month>
          <volume>36</volume>
          <issue>10</issue>
          <fpage>1163</fpage>
          <lpage>75</lpage>
          <pub-id pub-id-type="doi">10.1080/10410236.2020.1748829</pub-id>
          <pub-id pub-id-type="medline">32290679</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref52">
        <label>52</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ali</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Farrer</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Gulliver</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Griffiths</surname>
              <given-names>KM</given-names>
            </name>
          </person-group>
          <article-title>Online peer-to-peer support for young people with mental health problems: a systematic review</article-title>
          <source>JMIR Ment Health</source>
          <year>2015</year>
          <month>5</month>
          <day>19</day>
          <volume>2</volume>
          <issue>2</issue>
          <fpage>e19</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://mental.jmir.org/2015/2/e19/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/mental.4418</pub-id>
          <pub-id pub-id-type="medline">26543923</pub-id>
          <pub-id pub-id-type="pii">v2i2e19</pub-id>
          <pub-id pub-id-type="pmcid">PMC4607385</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref53">
        <label>53</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ebert</surname>
              <given-names>DD</given-names>
            </name>
            <name name-style="western">
              <surname>Donkin</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Andersson</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Andrews</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Berger</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Carlbring</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Rozenthal</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Choi</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>Laferton</surname>
              <given-names>JA</given-names>
            </name>
            <name name-style="western">
              <surname>Johansson</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Kleiboer</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Lange</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Lehr</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Reins</surname>
              <given-names>JA</given-names>
            </name>
            <name name-style="western">
              <surname>Funk</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Newby</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Perini</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Riper</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Ruwaard</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Sheeber</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Snoek</surname>
              <given-names>FJ</given-names>
            </name>
            <name name-style="western">
              <surname>Titov</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Ünlü Ince</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>van Bastelaar</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Vernmark</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>van Straten</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Warmerdam</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Salsman</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Cuijpers</surname>
              <given-names>P</given-names>
            </name>
          </person-group>
          <article-title>Does Internet-based guided-self-help for depression cause harm? An individual participant data meta-analysis on deterioration rates and its moderators in randomized controlled trials</article-title>
          <source>Psychol Med</source>
          <year>2016</year>
          <month>10</month>
          <volume>46</volume>
          <issue>13</issue>
          <fpage>2679</fpage>
          <lpage>93</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://boris.unibe.ch/id/eprint/94893"/>
          </comment>
          <pub-id pub-id-type="doi">10.1017/S0033291716001562</pub-id>
          <pub-id pub-id-type="medline">27649340</pub-id>
          <pub-id pub-id-type="pii">S0033291716001562</pub-id>
          <pub-id pub-id-type="pmcid">PMC5560500</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref54">
        <label>54</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Frost</surname>
              <given-names>RL</given-names>
            </name>
            <name name-style="western">
              <surname>Rickwood</surname>
              <given-names>DJ</given-names>
            </name>
          </person-group>
          <article-title>A systematic review of the mental health outcomes associated with Facebook use</article-title>
          <source>Comput Human Behav</source>
          <year>2017</year>
          <month>11</month>
          <volume>76</volume>
          <fpage>576</fpage>
          <lpage>600</lpage>
          <pub-id pub-id-type="doi">10.1016/j.chb.2017.08.001</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref55">
        <label>55</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Griffiths</surname>
              <given-names>KM</given-names>
            </name>
            <name name-style="western">
              <surname>Calear</surname>
              <given-names>AL</given-names>
            </name>
            <name name-style="western">
              <surname>Banfield</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Systematic review on Internet Support Groups (ISGs) and depression (1): do ISGs reduce depressive symptoms?</article-title>
          <source>J Med Internet Res</source>
          <year>2009</year>
          <month>09</month>
          <day>30</day>
          <volume>11</volume>
          <issue>3</issue>
          <fpage>e40</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2009/3/e40/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.1270</pub-id>
          <pub-id pub-id-type="medline">19793719</pub-id>
          <pub-id pub-id-type="pii">v11i3e40</pub-id>
          <pub-id pub-id-type="pmcid">PMC2802256</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref56">
        <label>56</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Griffiths</surname>
              <given-names>KM</given-names>
            </name>
            <name name-style="western">
              <surname>Calear</surname>
              <given-names>AL</given-names>
            </name>
            <name name-style="western">
              <surname>Banfield</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Tam</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Systematic review on Internet Support Groups (ISGs) and depression (2): what is known about depression ISGs?</article-title>
          <source>J Med Internet Res</source>
          <year>2009</year>
          <month>09</month>
          <day>30</day>
          <volume>11</volume>
          <issue>3</issue>
          <fpage>e41</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2009/3/e41/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.1303</pub-id>
          <pub-id pub-id-type="medline">19793718</pub-id>
          <pub-id pub-id-type="pii">v11i3e41</pub-id>
          <pub-id pub-id-type="pmcid">PMC2802257</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref57">
        <label>57</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Burns</surname>
              <given-names>JM</given-names>
            </name>
            <name name-style="western">
              <surname>Davenport</surname>
              <given-names>TA</given-names>
            </name>
            <name name-style="western">
              <surname>Christensen</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Luscombe</surname>
              <given-names>GM</given-names>
            </name>
            <name name-style="western">
              <surname>Mendoza</surname>
              <given-names>JA</given-names>
            </name>
            <name name-style="western">
              <surname>Bresnan</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Blanchard</surname>
              <given-names>ME</given-names>
            </name>
            <name name-style="western">
              <surname>Hickie</surname>
              <given-names>IB</given-names>
            </name>
          </person-group>
          <article-title>Game On: Exploring the Impact of Technologies on Young Men's Mental Health and Wellbeing</article-title>
          <source>Young and Well Cooperative Research Centre</source>
          <year>2013</year>
          <month>7</month>
          <access-date>2022-12-30</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://apo.org.au/sites/default/files/resource-files/2013-07/apo-nid34943.pdf">https://apo.org.au/sites/default/files/resource-files/2013-07/apo-nid34943.pdf</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref58">
        <label>58</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Reger</surname>
              <given-names>MA</given-names>
            </name>
            <name name-style="western">
              <surname>Gahm</surname>
              <given-names>GA</given-names>
            </name>
          </person-group>
          <article-title>A meta-analysis of the effects of internet- and computer-based cognitive-behavioral treatments for anxiety</article-title>
          <source>J Clin Psychol</source>
          <year>2009</year>
          <month>01</month>
          <volume>65</volume>
          <issue>1</issue>
          <fpage>53</fpage>
          <lpage>75</lpage>
          <pub-id pub-id-type="doi">10.1002/jclp.20536</pub-id>
          <pub-id pub-id-type="medline">19051274</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref59">
        <label>59</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Rice</surname>
              <given-names>SM</given-names>
            </name>
            <name name-style="western">
              <surname>Goodall</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Hetrick</surname>
              <given-names>SE</given-names>
            </name>
            <name name-style="western">
              <surname>Parker</surname>
              <given-names>AG</given-names>
            </name>
            <name name-style="western">
              <surname>Gilbertson</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Amminger</surname>
              <given-names>GP</given-names>
            </name>
            <name name-style="western">
              <surname>Davey</surname>
              <given-names>CG</given-names>
            </name>
            <name name-style="western">
              <surname>McGorry</surname>
              <given-names>PD</given-names>
            </name>
            <name name-style="western">
              <surname>Gleeson</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Alvarez-Jimenez</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Online and social networking interventions for the treatment of depression in young people: a systematic review</article-title>
          <source>J Med Internet Res</source>
          <year>2014</year>
          <month>09</month>
          <day>16</day>
          <volume>16</volume>
          <issue>9</issue>
          <fpage>e206</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2014/9/e206/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.3304</pub-id>
          <pub-id pub-id-type="medline">25226790</pub-id>
          <pub-id pub-id-type="pii">v16i9e206</pub-id>
          <pub-id pub-id-type="pmcid">PMC4180352</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref60">
        <label>60</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Papp-Zipernovszky</surname>
              <given-names>O</given-names>
            </name>
            <name name-style="western">
              <surname>Csabai</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Schulz</surname>
              <given-names>PJ</given-names>
            </name>
            <name name-style="western">
              <surname>Varga</surname>
              <given-names>JT</given-names>
            </name>
          </person-group>
          <article-title>Does health literacy reinforce disease knowledge gain? A prospective observational study of Hungarian COPD patients</article-title>
          <source>J Clin Med</source>
          <year>2021</year>
          <month>09</month>
          <day>03</day>
          <volume>10</volume>
          <issue>17</issue>
          <fpage>3990</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.mdpi.com/resolver?pii=jcm10173990"/>
          </comment>
          <pub-id pub-id-type="doi">10.3390/jcm10173990</pub-id>
          <pub-id pub-id-type="medline">34501438</pub-id>
          <pub-id pub-id-type="pii">jcm10173990</pub-id>
          <pub-id pub-id-type="pmcid">PMC8432554</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref61">
        <label>61</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>McCrindle</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Understanding Generation Z: Recruiting, Training and Leading the Next Generation</article-title>
          <source>Academia</source>
          <year>2019</year>
          <access-date>2022-12-27</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://generationz.com.au/wp-content/uploads/2019/12/Understanding_Generation_Z_report_McCrindle.pdf">https://generationz.com.au/wp-content/uploads/2019/12/Understanding_Generation_Z_report_McCrindle.pdf</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref62">
        <label>62</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Moher</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Liberati</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Tetzlaff</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Altman</surname>
              <given-names>DG</given-names>
            </name>
            <collab>PRISMA Group</collab>
          </person-group>
          <article-title>Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement</article-title>
          <source>PLoS Med</source>
          <year>2009</year>
          <month>07</month>
          <day>21</day>
          <volume>6</volume>
          <issue>7</issue>
          <fpage>e1000097</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://dx.plos.org/10.1371/journal.pmed.1000097"/>
          </comment>
          <pub-id pub-id-type="doi">10.1371/journal.pmed.1000097</pub-id>
          <pub-id pub-id-type="medline">19621072</pub-id>
          <pub-id pub-id-type="pmcid">PMC2707599</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref63">
        <label>63</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ouzzani</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Hammady</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Fedorowicz</surname>
              <given-names>Z</given-names>
            </name>
            <name name-style="western">
              <surname>Elmagarmid</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Rayyan-a web and mobile app for systematic reviews</article-title>
          <source>Syst Rev</source>
          <year>2016</year>
          <month>12</month>
          <day>05</day>
          <volume>5</volume>
          <issue>1</issue>
          <fpage>210</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-016-0384-4"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/s13643-016-0384-4</pub-id>
          <pub-id pub-id-type="medline">27919275</pub-id>
          <pub-id pub-id-type="pii">10.1186/s13643-016-0384-4</pub-id>
          <pub-id pub-id-type="pmcid">PMC5139140</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref64">
        <label>64</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Toscos</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Coupe</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Flanagan</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Drouin</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Carpenter</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Reining</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Roebuck</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Mirro</surname>
              <given-names>MJ</given-names>
            </name>
          </person-group>
          <article-title>Teens using screens for help: impact of suicidal ideation, anxiety, and depression levels on youth preferences for telemental health resources</article-title>
          <source>JMIR Ment Health</source>
          <year>2019</year>
          <month>06</month>
          <day>21</day>
          <volume>6</volume>
          <issue>6</issue>
          <fpage>e13230</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://mental.jmir.org/2019/6/e13230/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/13230</pub-id>
          <pub-id pub-id-type="medline">31228179</pub-id>
          <pub-id pub-id-type="pii">v6i6e13230</pub-id>
          <pub-id pub-id-type="pmcid">PMC6611146</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref65">
        <label>65</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Van Meter</surname>
              <given-names>AR</given-names>
            </name>
            <name name-style="western">
              <surname>Birnbaum</surname>
              <given-names>ML</given-names>
            </name>
            <name name-style="western">
              <surname>Rizvi</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Kane</surname>
              <given-names>JM</given-names>
            </name>
          </person-group>
          <article-title>Online help-seeking prior to diagnosis: can web-based resources reduce the duration of untreated mood disorders in young people?</article-title>
          <source>J Affect Disord</source>
          <year>2019</year>
          <month>06</month>
          <day>01</day>
          <volume>252</volume>
          <fpage>130</fpage>
          <lpage>4</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/30981056"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.jad.2019.04.019</pub-id>
          <pub-id pub-id-type="medline">30981056</pub-id>
          <pub-id pub-id-type="pii">S0165-0327(18)33288-9</pub-id>
          <pub-id pub-id-type="pmcid">PMC6529208</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref66">
        <label>66</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>DeAndrea</surname>
              <given-names>DC</given-names>
            </name>
            <name name-style="western">
              <surname>Anthony</surname>
              <given-names>JC</given-names>
            </name>
          </person-group>
          <article-title>Online peer support for mental health problems in the United States: 2004-2010</article-title>
          <source>Psychol Med</source>
          <year>2013</year>
          <month>11</month>
          <volume>43</volume>
          <issue>11</issue>
          <fpage>2277</fpage>
          <lpage>88</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/23410539"/>
          </comment>
          <pub-id pub-id-type="doi">10.1017/S0033291713000172</pub-id>
          <pub-id pub-id-type="medline">23410539</pub-id>
          <pub-id pub-id-type="pii">S0033291713000172</pub-id>
          <pub-id pub-id-type="pmcid">PMC4327823</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref67">
        <label>67</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Fonseca</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Gorayeb</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Canavarro</surname>
              <given-names>MC</given-names>
            </name>
          </person-group>
          <article-title>Women's use of online resources and acceptance of e-mental health tools during the perinatal period</article-title>
          <source>Int J Med Inform</source>
          <year>2016</year>
          <month>10</month>
          <volume>94</volume>
          <fpage>228</fpage>
          <lpage>36</lpage>
          <pub-id pub-id-type="doi">10.1016/j.ijmedinf.2016.07.016</pub-id>
          <pub-id pub-id-type="medline">27573331</pub-id>
          <pub-id pub-id-type="pii">S1386-5056(16)30177-0</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref68">
        <label>68</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Köhle</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Drossaert</surname>
              <given-names>CH</given-names>
            </name>
            <name name-style="western">
              <surname>Van Uden-Kraan</surname>
              <given-names>CF</given-names>
            </name>
            <name name-style="western">
              <surname>Schreurs</surname>
              <given-names>KM</given-names>
            </name>
            <name name-style="western">
              <surname>Hagedoorn</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Verdonck-de Leeuw</surname>
              <given-names>IM</given-names>
            </name>
            <name name-style="western">
              <surname>Bohlmeijer</surname>
              <given-names>ET</given-names>
            </name>
          </person-group>
          <article-title>Intent to use a web-based psychological intervention for partners of cancer patients: associated factors and preferences</article-title>
          <source>J Psychosoc Oncol</source>
          <year>2018</year>
          <volume>36</volume>
          <issue>2</issue>
          <fpage>203</fpage>
          <lpage>21</lpage>
          <pub-id pub-id-type="doi">10.1080/07347332.2017.1397831</pub-id>
          <pub-id pub-id-type="medline">29336704</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref69">
        <label>69</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>March</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Day</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Ritchie</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Rowe</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Gough</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Hall</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Yuen</surname>
              <given-names>CY</given-names>
            </name>
            <name name-style="western">
              <surname>Donovan</surname>
              <given-names>CL</given-names>
            </name>
            <name name-style="western">
              <surname>Ireland</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Attitudes toward e-mental health services in a community sample of adults: online survey</article-title>
          <source>J Med Internet Res</source>
          <year>2018</year>
          <month>02</month>
          <day>19</day>
          <volume>20</volume>
          <issue>2</issue>
          <fpage>e59</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2018/2/e59/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.9109</pub-id>
          <pub-id pub-id-type="medline">29459357</pub-id>
          <pub-id pub-id-type="pii">v20i2e59</pub-id>
          <pub-id pub-id-type="pmcid">PMC5838359</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref70">
        <label>70</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Toscos</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Carpenter</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Drouin</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Roebuck</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Kerrigan</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Mirro</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>College students' experiences with, and willingness to use, different types of telemental health resources: do gender, depression/anxiety, or stress levels matter?</article-title>
          <source>Telemed J E Health</source>
          <year>2018</year>
          <month>12</month>
          <volume>24</volume>
          <issue>12</issue>
          <fpage>998</fpage>
          <lpage>1005</lpage>
          <pub-id pub-id-type="doi">10.1089/tmj.2017.0243</pub-id>
          <pub-id pub-id-type="medline">29658826</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref71">
        <label>71</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Yu</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Li</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Li</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Xi</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Xiao</surname>
              <given-names>X</given-names>
            </name>
            <name name-style="western">
              <surname>Xiao</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Tebes</surname>
              <given-names>JK</given-names>
            </name>
          </person-group>
          <article-title>New path to recovery and well-being: cross-sectional study on WeChat use and endorsement of WeChat-based mHealth among people living with schizophrenia in China</article-title>
          <source>J Med Internet Res</source>
          <year>2020</year>
          <month>09</month>
          <day>18</day>
          <volume>22</volume>
          <issue>9</issue>
          <fpage>e18663</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2020/9/e18663/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/18663</pub-id>
          <pub-id pub-id-type="medline">32945774</pub-id>
          <pub-id pub-id-type="pii">v22i9e18663</pub-id>
          <pub-id pub-id-type="pmcid">PMC7532456</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref72">
        <label>72</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Houston</surname>
              <given-names>TK</given-names>
            </name>
            <name name-style="western">
              <surname>Cooper</surname>
              <given-names>LA</given-names>
            </name>
            <name name-style="western">
              <surname>Ford</surname>
              <given-names>DE</given-names>
            </name>
          </person-group>
          <article-title>Internet support groups for depression: a 1-year prospective cohort study</article-title>
          <source>Am J Psychiatry</source>
          <year>2002</year>
          <month>12</month>
          <volume>159</volume>
          <issue>12</issue>
          <fpage>2062</fpage>
          <lpage>8</lpage>
          <pub-id pub-id-type="doi">10.1176/appi.ajp.159.12.2062</pub-id>
          <pub-id pub-id-type="medline">12450957</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref73">
        <label>73</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Giallo</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Dunning</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Gent</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Attitudinal barriers to help-seeking and preferences for mental health support among Australian fathers</article-title>
          <source>J Reprod Infant Psychol</source>
          <year>2017</year>
          <month>07</month>
          <volume>35</volume>
          <issue>3</issue>
          <fpage>236</fpage>
          <lpage>47</lpage>
          <pub-id pub-id-type="doi">10.1080/02646838.2017.1298084</pub-id>
          <pub-id pub-id-type="medline">29517311</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref74">
        <label>74</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Leech</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Dorstyn</surname>
              <given-names>DS</given-names>
            </name>
            <name name-style="western">
              <surname>Li</surname>
              <given-names>W</given-names>
            </name>
          </person-group>
          <article-title>eMental health service use among Australian youth: a cross-sectional survey framed by Andersen's model</article-title>
          <source>Aust Health Rev</source>
          <year>2020</year>
          <month>12</month>
          <volume>44</volume>
          <issue>6</issue>
          <fpage>891</fpage>
          <lpage>7</lpage>
          <pub-id pub-id-type="doi">10.1071/AH19095</pub-id>
          <pub-id pub-id-type="medline">31837712</pub-id>
          <pub-id pub-id-type="pii">AH19095</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref75">
        <label>75</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Gold</surname>
              <given-names>KJ</given-names>
            </name>
            <name name-style="western">
              <surname>Normandin</surname>
              <given-names>MM</given-names>
            </name>
            <name name-style="western">
              <surname>Boggs</surname>
              <given-names>ME</given-names>
            </name>
          </person-group>
          <article-title>Are participants in face-to-face and internet support groups the same? Comparison of demographics and depression levels among women bereaved by stillbirth</article-title>
          <source>Arch Womens Ment Health</source>
          <year>2016</year>
          <month>12</month>
          <volume>19</volume>
          <issue>6</issue>
          <fpage>1073</fpage>
          <lpage>8</lpage>
          <pub-id pub-id-type="doi">10.1007/s00737-016-0657-x</pub-id>
          <pub-id pub-id-type="medline">27562824</pub-id>
          <pub-id pub-id-type="pii">10.1007/s00737-016-0657-x</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref76">
        <label>76</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Simmons</surname>
              <given-names>LA</given-names>
            </name>
            <name name-style="western">
              <surname>Wu</surname>
              <given-names>Q</given-names>
            </name>
            <name name-style="western">
              <surname>Yang</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Bush</surname>
              <given-names>HM</given-names>
            </name>
            <name name-style="western">
              <surname>Crofford</surname>
              <given-names>LJ</given-names>
            </name>
          </person-group>
          <article-title>Sources of health information among rural women in Western Kentucky</article-title>
          <source>Public Health Nurs</source>
          <year>2015</year>
          <volume>32</volume>
          <issue>1</issue>
          <fpage>3</fpage>
          <lpage>14</lpage>
          <pub-id pub-id-type="doi">10.1111/phn.12134</pub-id>
          <pub-id pub-id-type="medline">24905745</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref77">
        <label>77</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>McNair</surname>
              <given-names>RP</given-names>
            </name>
            <name name-style="western">
              <surname>Bush</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <article-title>Mental health help seeking patterns and associations among Australian same sex attracted women, trans and gender diverse people: a survey-based study</article-title>
          <source>BMC Psychiatry</source>
          <year>2016</year>
          <month>07</month>
          <day>04</day>
          <volume>16</volume>
          <fpage>209</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-016-0916-4"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/s12888-016-0916-4</pub-id>
          <pub-id pub-id-type="medline">27377408</pub-id>
          <pub-id pub-id-type="pii">10.1186/s12888-016-0916-4</pub-id>
          <pub-id pub-id-type="pmcid">PMC4932693</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref78">
        <label>78</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Akhther</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Sopory</surname>
              <given-names>P</given-names>
            </name>
          </person-group>
          <article-title>Seeking and sharing mental health information on social media during COVID-19: role of depression and anxiety, peer support, and health benefits</article-title>
          <source>J Technol Behav Sci</source>
          <year>2022</year>
          <volume>7</volume>
          <issue>2</issue>
          <fpage>211</fpage>
          <lpage>26</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/35036521"/>
          </comment>
          <pub-id pub-id-type="doi">10.1007/s41347-021-00239-x</pub-id>
          <pub-id pub-id-type="medline">35036521</pub-id>
          <pub-id pub-id-type="pii">239</pub-id>
          <pub-id pub-id-type="pmcid">PMC8749346</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref79">
        <label>79</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kramer</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Boon</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Schotanus-Dijkstra</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>van Ballegooijen</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Kerkhof</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>van der Poel</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>The mental health of visitors of web-based support forums for bereaved by suicide</article-title>
          <source>Crisis</source>
          <year>2015</year>
          <volume>36</volume>
          <issue>1</issue>
          <fpage>38</fpage>
          <lpage>45</lpage>
          <pub-id pub-id-type="doi">10.1027/0227-5910/a000281</pub-id>
          <pub-id pub-id-type="medline">25410257</pub-id>
          <pub-id pub-id-type="pii">X0658R36051J7383</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref80">
        <label>80</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Millard</surname>
              <given-names>RW</given-names>
            </name>
            <name name-style="western">
              <surname>Fintak</surname>
              <given-names>PA</given-names>
            </name>
          </person-group>
          <article-title>Use of the Internet by patients with chronic illness</article-title>
          <source>Dis Manag Health Outcomes</source>
          <year>2002</year>
          <volume>10</volume>
          <issue>3</issue>
          <fpage>187</fpage>
          <lpage>194</lpage>
          <pub-id pub-id-type="doi">10.2165/00115677-200210030-00006</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref81">
        <label>81</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Mo</surname>
              <given-names>PK</given-names>
            </name>
            <name name-style="western">
              <surname>Coulson</surname>
              <given-names>NS</given-names>
            </name>
          </person-group>
          <article-title>Online support group use and psychological health for individuals living with HIV/AIDS</article-title>
          <source>Patient Educ Couns</source>
          <year>2013</year>
          <month>12</month>
          <volume>93</volume>
          <issue>3</issue>
          <fpage>426</fpage>
          <lpage>32</lpage>
          <pub-id pub-id-type="doi">10.1016/j.pec.2013.04.004</pub-id>
          <pub-id pub-id-type="medline">23669152</pub-id>
          <pub-id pub-id-type="pii">S0738-3991(13)00135-3</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref82">
        <label>82</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Nimrod</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Online depression communities: members' interests and perceived benefits</article-title>
          <source>Health Commun</source>
          <year>2013</year>
          <volume>28</volume>
          <issue>5</issue>
          <fpage>425</fpage>
          <lpage>34</lpage>
          <pub-id pub-id-type="doi">10.1080/10410236.2012.691068</pub-id>
          <pub-id pub-id-type="medline">22809441</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref83">
        <label>83</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Powell</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>McCarthy</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Eysenbach</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Cross-sectional survey of users of Internet depression communities</article-title>
          <source>BMC Psychiatry</source>
          <year>2003</year>
          <month>12</month>
          <day>10</day>
          <volume>3</volume>
          <fpage>19</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcpsychiatry.biomedcentral.com/articles/10.1186/1471-244X-3-19"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/1471-244X-3-19</pub-id>
          <pub-id pub-id-type="medline">14664725</pub-id>
          <pub-id pub-id-type="pii">1471-244X-3-19</pub-id>
          <pub-id pub-id-type="pmcid">PMC317315</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref84">
        <label>84</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Han</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Guo</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Hong</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>Impact of professionally facilitated peer support for family carers of people with dementia in a WeChat virtual community</article-title>
          <source>J Telemed Telecare</source>
          <year>2022</year>
          <month>01</month>
          <volume>28</volume>
          <issue>1</issue>
          <fpage>68</fpage>
          <lpage>76</lpage>
          <pub-id pub-id-type="doi">10.1177/1357633X20910830</pub-id>
          <pub-id pub-id-type="medline">32192386</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref85">
        <label>85</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Higueras</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Salas</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Meca-Lallana</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Carrascal Rueda</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Rodríguez De la Fuente</surname>
              <given-names>O</given-names>
            </name>
            <name name-style="western">
              <surname>Cabello-Moruno</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Maurino</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Ruiz Díaz</surname>
              <given-names>MÁ</given-names>
            </name>
          </person-group>
          <article-title>Information-seeking strategies of people with multiple sclerosis in Spain: the INFOSEEK-MS study</article-title>
          <source>Patient Prefer Adherence</source>
          <year>2022</year>
          <month>1</month>
          <day>11</day>
          <volume>16</volume>
          <fpage>51</fpage>
          <lpage>60</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/35046641"/>
          </comment>
          <pub-id pub-id-type="doi">10.2147/PPA.S344690</pub-id>
          <pub-id pub-id-type="medline">35046641</pub-id>
          <pub-id pub-id-type="pii">344690</pub-id>
          <pub-id pub-id-type="pmcid">PMC8762518</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref86">
        <label>86</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Nimrod</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>From knowledge to hope: online depression communities</article-title>
          <source>Int J Disabil Hum Dev</source>
          <year>2012</year>
          <month>3</month>
          <day>1</day>
          <volume>11</volume>
          <issue>1</issue>
          <fpage>23</fpage>
          <lpage>30</lpage>
          <pub-id pub-id-type="doi">10.1515/ijdhd.2012.009</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref87">
        <label>87</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Oh</surname>
              <given-names>YS</given-names>
            </name>
            <name name-style="western">
              <surname>Song</surname>
              <given-names>NK</given-names>
            </name>
          </person-group>
          <article-title>Investigating relationships between health-related problems and online health information seeking</article-title>
          <source>Comput Inform Nurs</source>
          <year>2017</year>
          <month>01</month>
          <volume>35</volume>
          <issue>1</issue>
          <fpage>29</fpage>
          <lpage>35</lpage>
          <pub-id pub-id-type="doi">10.1097/CIN.0000000000000234</pub-id>
          <pub-id pub-id-type="medline">26950091</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref88">
        <label>88</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Simmons</surname>
              <given-names>CA</given-names>
            </name>
            <name name-style="western">
              <surname>Lindsey</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Delaney</surname>
              <given-names>MJ</given-names>
            </name>
            <name name-style="western">
              <surname>Whalley</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Beck</surname>
              <given-names>JG</given-names>
            </name>
          </person-group>
          <article-title>Real-world barriers to assessing and treating mental health problems with IPV survivors: a qualitative study</article-title>
          <source>J Interpers Violence</source>
          <year>2015</year>
          <month>07</month>
          <volume>30</volume>
          <issue>12</issue>
          <fpage>2067</fpage>
          <lpage>86</lpage>
          <pub-id pub-id-type="doi">10.1177/0886260514552275</pub-id>
          <pub-id pub-id-type="medline">25304669</pub-id>
          <pub-id pub-id-type="pii">0886260514552275</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref89">
        <label>89</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Radloff</surname>
              <given-names>LS</given-names>
            </name>
          </person-group>
          <article-title>The CES-D scale: a self-report depression scale for research in the general population</article-title>
          <source>Appl Psychol Meas</source>
          <year>2016</year>
          <month>07</month>
          <day>26</day>
          <volume>1</volume>
          <issue>3</issue>
          <fpage>385</fpage>
          <lpage>401</lpage>
          <pub-id pub-id-type="doi">10.1177/014662167700100306</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref90">
        <label>90</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>McKechnie</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Barker</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Stott</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>The effectiveness of an Internet support forum for carers of people with dementia: a pre-post cohort study</article-title>
          <source>J Med Internet Res</source>
          <year>2014</year>
          <month>02</month>
          <day>28</day>
          <volume>16</volume>
          <issue>2</issue>
          <fpage>e68</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2014/2/e68/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.3166</pub-id>
          <pub-id pub-id-type="medline">24583789</pub-id>
          <pub-id pub-id-type="pii">v16i2e68</pub-id>
          <pub-id pub-id-type="pmcid">PMC3961748</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref91">
        <label>91</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Nimrod</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>The membership life cycle in online support groups</article-title>
          <source>Int J Commun</source>
          <year>2012</year>
          <volume>6</volume>
          <issue>2012</issue>
          <fpage>1245</fpage>
          <lpage>61</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://ijoc.org/index.php/ijoc/article/view/1399/757"/>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref92">
        <label>92</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Trail</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Friedman</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Rutter</surname>
              <given-names>CM</given-names>
            </name>
            <name name-style="western">
              <surname>Tanielian</surname>
              <given-names>T</given-names>
            </name>
          </person-group>
          <article-title>The relationship between engagement in online support groups and social isolation among military caregivers: longitudinal questionnaire study</article-title>
          <source>J Med Internet Res</source>
          <year>2020</year>
          <month>04</month>
          <day>23</day>
          <volume>22</volume>
          <issue>4</issue>
          <fpage>e16423</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2020/4/e16423/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/16423</pub-id>
          <pub-id pub-id-type="medline">32324141</pub-id>
          <pub-id pub-id-type="pii">v22i4e16423</pub-id>
          <pub-id pub-id-type="pmcid">PMC7206524</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref93">
        <label>93</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Batenburg</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Das</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>Emotional approach coping and the effects of online peer-led support group participation among patients with breast cancer: a longitudinal study</article-title>
          <source>J Med Internet Res</source>
          <year>2014</year>
          <month>11</month>
          <day>28</day>
          <volume>16</volume>
          <issue>11</issue>
          <fpage>e256</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2014/11/e256/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.3517</pub-id>
          <pub-id pub-id-type="medline">25474819</pub-id>
          <pub-id pub-id-type="pii">v16i11e256</pub-id>
          <pub-id pub-id-type="pmcid">PMC4260065</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref94">
        <label>94</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Wagner</surname>
              <given-names>TH</given-names>
            </name>
            <name name-style="western">
              <surname>Hibbard</surname>
              <given-names>JH</given-names>
            </name>
          </person-group>
          <article-title>Who uses self-care books, advice nurses, and computers for health information?</article-title>
          <source>Int J Technol Assess Health Care</source>
          <year>2001</year>
          <volume>17</volume>
          <issue>4</issue>
          <fpage>590</fpage>
          <lpage>600</lpage>
          <pub-id pub-id-type="medline">11758302</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref95">
        <label>95</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Marinova</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Rogers</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>MacBeth</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Predictors of adolescent engagement and outcomes - a cross-sectional study using the togetherall (formerly Big White Wall) digital mental health platform</article-title>
          <source>J Affect Disord</source>
          <year>2022</year>
          <month>08</month>
          <day>15</day>
          <volume>311</volume>
          <fpage>284</fpage>
          <lpage>93</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(22)00572-9"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.jad.2022.05.058</pub-id>
          <pub-id pub-id-type="medline">35588912</pub-id>
          <pub-id pub-id-type="pii">S0165-0327(22)00572-9</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref96">
        <label>96</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Huber</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Muck</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Maatz</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Keck</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Enders</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Maatouk</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>Ihrig</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Face-to-face vs. online peer support groups for prostate cancer: a cross-sectional comparison study</article-title>
          <source>J Cancer Surviv</source>
          <year>2018</year>
          <month>02</month>
          <volume>12</volume>
          <issue>1</issue>
          <fpage>1</fpage>
          <lpage>9</lpage>
          <pub-id pub-id-type="doi">10.1007/s11764-017-0633-0</pub-id>
          <pub-id pub-id-type="medline">28861845</pub-id>
          <pub-id pub-id-type="pii">10.1007/s11764-017-0633-0</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref97">
        <label>97</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Brailovskaia</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Margraf</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>Comparing Facebook users and Facebook non-users: relationship between personality traits and mental health variables - an exploratory study</article-title>
          <source>PLoS One</source>
          <year>2016</year>
          <month>12</month>
          <day>1</day>
          <volume>11</volume>
          <issue>12</issue>
          <fpage>e0166999</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://dx.plos.org/10.1371/journal.pone.0166999"/>
          </comment>
          <pub-id pub-id-type="doi">10.1371/journal.pone.0166999</pub-id>
          <pub-id pub-id-type="medline">27907020</pub-id>
          <pub-id pub-id-type="pii">PONE-D-16-30486</pub-id>
          <pub-id pub-id-type="pmcid">PMC5131958</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref98">
        <label>98</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Park</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Lee</surname>
              <given-names>DS</given-names>
            </name>
            <name name-style="western">
              <surname>Shablack</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Verduyn</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Deldin</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Ybarra</surname>
              <given-names>O</given-names>
            </name>
            <name name-style="western">
              <surname>Jonides</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Kross</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>When perceptions defy reality: the relationships between depression and actual and perceived Facebook social support</article-title>
          <source>J Affect Disord</source>
          <year>2016</year>
          <month>08</month>
          <volume>200</volume>
          <fpage>37</fpage>
          <lpage>44</lpage>
          <pub-id pub-id-type="doi">10.1016/j.jad.2016.01.048</pub-id>
          <pub-id pub-id-type="medline">27126138</pub-id>
          <pub-id pub-id-type="pii">S0165-0327(15)30863-6</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref99">
        <label>99</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>van Dijck</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <source>The Culture of Connectivity: A Critical History of Social Media</source>
          <year>2013</year>
          <publisher-loc>Oxford, UK</publisher-loc>
          <publisher-name>Oxford University Press</publisher-name>
        </nlm-citation>
      </ref>
      <ref id="ref100">
        <label>100</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Algtewi</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Owens</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Baker</surname>
              <given-names>SR</given-names>
            </name>
          </person-group>
          <article-title>Online support groups for head and neck cancer and health-related quality of life</article-title>
          <source>Qual Life Res</source>
          <year>2017</year>
          <month>09</month>
          <volume>26</volume>
          <issue>9</issue>
          <fpage>2351</fpage>
          <lpage>62</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/28417218"/>
          </comment>
          <pub-id pub-id-type="doi">10.1007/s11136-017-1575-8</pub-id>
          <pub-id pub-id-type="medline">28417218</pub-id>
          <pub-id pub-id-type="pii">10.1007/s11136-017-1575-8</pub-id>
          <pub-id pub-id-type="pmcid">PMC5548849</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref101">
        <label>101</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Klemm</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Hardie</surname>
              <given-names>T</given-names>
            </name>
          </person-group>
          <article-title>Depression in Internet and face-to-face cancer support groups: a pilot study</article-title>
          <source>Oncol Nurs Forum</source>
          <year>2002</year>
          <month>05</month>
          <volume>29</volume>
          <issue>4</issue>
          <fpage>E45</fpage>
          <lpage>51</lpage>
          <pub-id pub-id-type="doi">10.1188/02.ONF.E45-E51</pub-id>
          <pub-id pub-id-type="medline">12011918</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref102">
        <label>102</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kumar</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Tran</surname>
              <given-names>JL</given-names>
            </name>
            <name name-style="western">
              <surname>Ramirez</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Lee</surname>
              <given-names>WN</given-names>
            </name>
            <name name-style="western">
              <surname>Foschini</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Juusola</surname>
              <given-names>JL</given-names>
            </name>
          </person-group>
          <article-title>Design, recruitment, and baseline characteristics of a virtual 1-year mental health study on behavioral data and health outcomes: observational Study</article-title>
          <source>JMIR Ment Health</source>
          <year>2020</year>
          <month>07</month>
          <day>23</day>
          <volume>7</volume>
          <issue>7</issue>
          <fpage>e17075</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://mental.jmir.org/2020/7/e17075/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/17075</pub-id>
          <pub-id pub-id-type="medline">32706712</pub-id>
          <pub-id pub-id-type="pii">v7i7e17075</pub-id>
          <pub-id pub-id-type="pmcid">PMC7413286</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref103">
        <label>103</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lieberman</surname>
              <given-names>MA</given-names>
            </name>
            <name name-style="western">
              <surname>Goldstein</surname>
              <given-names>BA</given-names>
            </name>
          </person-group>
          <article-title>Self-help on-line: an outcome evaluation of breast cancer bulletin boards</article-title>
          <source>J Health Psychol</source>
          <year>2005</year>
          <month>11</month>
          <volume>10</volume>
          <issue>6</issue>
          <fpage>855</fpage>
          <lpage>62</lpage>
          <pub-id pub-id-type="doi">10.1177/1359105305057319</pub-id>
          <pub-id pub-id-type="medline">16176962</pub-id>
          <pub-id pub-id-type="pii">10/6/855</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref104">
        <label>104</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Meng</surname>
              <given-names>X</given-names>
            </name>
            <name name-style="western">
              <surname>D'Arcy</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Adams</surname>
              <given-names>GC</given-names>
            </name>
          </person-group>
          <article-title>Associations between adult attachment style and mental health care utilization: findings from a large-scale national survey</article-title>
          <source>Psychiatry Res</source>
          <year>2015</year>
          <month>09</month>
          <day>30</day>
          <volume>229</volume>
          <issue>1-2</issue>
          <fpage>454</fpage>
          <lpage>61</lpage>
          <pub-id pub-id-type="doi">10.1016/j.psychres.2015.05.092</pub-id>
          <pub-id pub-id-type="medline">26213376</pub-id>
          <pub-id pub-id-type="pii">S0165-1781(15)00406-0</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref105">
        <label>105</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Merchant</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Goldin</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Manjanatha</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Harter</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Chandler</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Lipp</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Nguyen</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Naslund</surname>
              <given-names>JA</given-names>
            </name>
          </person-group>
          <article-title>Opportunities to expand access to mental health services: a case for the role of online peer support communities</article-title>
          <source>Psychiatr Q</source>
          <year>2022</year>
          <month>06</month>
          <volume>93</volume>
          <issue>2</issue>
          <fpage>613</fpage>
          <lpage>25</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/35226251"/>
          </comment>
          <pub-id pub-id-type="doi">10.1007/s11126-022-09974-7</pub-id>
          <pub-id pub-id-type="medline">35226251</pub-id>
          <pub-id pub-id-type="pii">10.1007/s11126-022-09974-7</pub-id>
          <pub-id pub-id-type="pmcid">PMC8883016</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref106">
        <label>106</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Naslund</surname>
              <given-names>JA</given-names>
            </name>
            <name name-style="western">
              <surname>Aschbrenner</surname>
              <given-names>KA</given-names>
            </name>
            <name name-style="western">
              <surname>Marsch</surname>
              <given-names>LA</given-names>
            </name>
            <name name-style="western">
              <surname>Bartels</surname>
              <given-names>SJ</given-names>
            </name>
          </person-group>
          <article-title>The future of mental health care: peer-to-peer support and social media</article-title>
          <source>Epidemiol Psychiatr Sci</source>
          <year>2016</year>
          <month>04</month>
          <volume>25</volume>
          <issue>2</issue>
          <fpage>113</fpage>
          <lpage>22</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/26744309"/>
          </comment>
          <pub-id pub-id-type="doi">10.1017/S2045796015001067</pub-id>
          <pub-id pub-id-type="medline">26744309</pub-id>
          <pub-id pub-id-type="pii">S2045796015001067</pub-id>
          <pub-id pub-id-type="pmcid">PMC4830464</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref107">
        <label>107</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Nimrod</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Online depression communities: does gender matter?</article-title>
          <source>Cyberpsychology</source>
          <year>2012</year>
          <volume>6</volume>
          <issue>1</issue>
          <fpage>6</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.5817/CP2012-1-6"/>
          </comment>
          <pub-id pub-id-type="doi">10.5817/CP2012-1-6</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref108">
        <label>108</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Roystonn</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Vaingankar</surname>
              <given-names>JA</given-names>
            </name>
            <name name-style="western">
              <surname>Chua</surname>
              <given-names>BY</given-names>
            </name>
            <name name-style="western">
              <surname>Sambasivam</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Shafie</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Jeyagurunathan</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Verma</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Abdin</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Chong</surname>
              <given-names>SA</given-names>
            </name>
            <name name-style="western">
              <surname>Subramaniam</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>The public health impact and policy implications of online support group use for mental health in Singapore: cross-sectional survey</article-title>
          <source>JMIR Ment Health</source>
          <year>2020</year>
          <month>08</month>
          <day>04</day>
          <volume>7</volume>
          <issue>8</issue>
          <fpage>e18114</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://mental.jmir.org/2020/8/e18114/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/18114</pub-id>
          <pub-id pub-id-type="medline">32749231</pub-id>
          <pub-id pub-id-type="pii">v7i8e18114</pub-id>
          <pub-id pub-id-type="pmcid">PMC7435627</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref109">
        <label>109</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Brunjes</surname>
              <given-names>K</given-names>
            </name>
          </person-group>
          <article-title>Age Range by Generation</article-title>
          <source>Beresford Research</source>
          <access-date>2021-10-18</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.beresfordresearch.com/age-range-by-generation/">https://www.beresfordresearch.com/age-range-by-generation/</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref110">
        <label>110</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Knottnerus</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Tugwell</surname>
              <given-names>P</given-names>
            </name>
          </person-group>
          <article-title>STROBE--a checklist to Strengthen the Reporting of Observational Studies in Epidemiology</article-title>
          <source>J Clin Epidemiol</source>
          <year>2008</year>
          <month>04</month>
          <volume>61</volume>
          <issue>4</issue>
          <fpage>323</fpage>
          <pub-id pub-id-type="doi">10.1016/j.jclinepi.2007.11.006</pub-id>
          <pub-id pub-id-type="medline">18313555</pub-id>
          <pub-id pub-id-type="pii">S0895-4356(07)00424-6</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref111">
        <label>111</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Schwarzer</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Carpenter</surname>
              <given-names>JR</given-names>
            </name>
            <name name-style="western">
              <surname>Rücker</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <source>Meta-Analysis with R</source>
          <year>2015</year>
          <publisher-loc>Cham, Switzerland</publisher-loc>
          <publisher-name>Springer</publisher-name>
        </nlm-citation>
      </ref>
      <ref id="ref112">
        <label>112</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Peterson</surname>
              <given-names>RA</given-names>
            </name>
            <name name-style="western">
              <surname>Brown</surname>
              <given-names>SP</given-names>
            </name>
          </person-group>
          <article-title>On the use of beta coefficients in meta-analysis</article-title>
          <source>J Appl Psychol</source>
          <year>2005</year>
          <month>01</month>
          <volume>90</volume>
          <issue>1</issue>
          <fpage>175</fpage>
          <lpage>81</lpage>
          <pub-id pub-id-type="doi">10.1037/0021-9010.90.1.175</pub-id>
          <pub-id pub-id-type="medline">15641898</pub-id>
          <pub-id pub-id-type="pii">2004-22497-013</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref113">
        <label>113</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lüdecke</surname>
              <given-names>D</given-names>
            </name>
          </person-group>
          <article-title>esc: Effect Size Computation for Meta Analysis</article-title>
          <source>Zenodo</source>
          <year>2018</year>
          <month>5</month>
          <day>18</day>
          <access-date>2022-12-27</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://zenodo.org/record/1249218#.Y6txf3bMJPY">https://zenodo.org/record/1249218#.Y6txf3bMJPY</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref114">
        <label>114</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>IntHout</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Ioannidis</surname>
              <given-names>JP</given-names>
            </name>
            <name name-style="western">
              <surname>Borm</surname>
              <given-names>GF</given-names>
            </name>
          </person-group>
          <article-title>The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method</article-title>
          <source>BMC Med Res Methodol</source>
          <year>2014</year>
          <month>02</month>
          <day>18</day>
          <volume>14</volume>
          <fpage>25</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/1471-2288-14-25"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/1471-2288-14-25</pub-id>
          <pub-id pub-id-type="medline">24548571</pub-id>
          <pub-id pub-id-type="pii">1471-2288-14-25</pub-id>
          <pub-id pub-id-type="pmcid">PMC4015721</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref115">
        <label>115</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Higgins</surname>
              <given-names>JP</given-names>
            </name>
            <name name-style="western">
              <surname>Thompson</surname>
              <given-names>SG</given-names>
            </name>
            <name name-style="western">
              <surname>Deeks</surname>
              <given-names>JJ</given-names>
            </name>
            <name name-style="western">
              <surname>Altman</surname>
              <given-names>DG</given-names>
            </name>
          </person-group>
          <article-title>Measuring inconsistency in meta-analyses</article-title>
          <source>BMJ</source>
          <year>2003</year>
          <month>09</month>
          <day>06</day>
          <volume>327</volume>
          <issue>7414</issue>
          <fpage>557</fpage>
          <lpage>60</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/12958120"/>
          </comment>
          <pub-id pub-id-type="doi">10.1136/bmj.327.7414.557</pub-id>
          <pub-id pub-id-type="medline">12958120</pub-id>
          <pub-id pub-id-type="pii">327/7414/557</pub-id>
          <pub-id pub-id-type="pmcid">PMC192859</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref116">
        <label>116</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ried</surname>
              <given-names>K</given-names>
            </name>
          </person-group>
          <article-title>Interpreting and understanding meta-analysis graphs--a practical guide</article-title>
          <source>Aust Fam Physician</source>
          <year>2006</year>
          <month>08</month>
          <volume>35</volume>
          <issue>8</issue>
          <fpage>635</fpage>
          <lpage>8</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://www.racgp.org.au/afp/200608/10624"/>
          </comment>
          <pub-id pub-id-type="medline">16894442</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref117">
        <label>117</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Mitchell</surname>
              <given-names>KM</given-names>
            </name>
            <name name-style="western">
              <surname>Holtz</surname>
              <given-names>BE</given-names>
            </name>
            <name name-style="western">
              <surname>McCarroll</surname>
              <given-names>AM</given-names>
            </name>
          </person-group>
          <article-title>Assessing college students' perceptions of and intentions to use a mobile app for mental health</article-title>
          <source>Telemed J E Health</source>
          <year>2022</year>
          <month>04</month>
          <volume>28</volume>
          <issue>4</issue>
          <fpage>566</fpage>
          <lpage>74</lpage>
          <pub-id pub-id-type="doi">10.1089/tmj.2021.0106</pub-id>
          <pub-id pub-id-type="medline">34166099</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref118">
        <label>118</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Grist</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Cliffe</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Denne</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Croker</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Stallard</surname>
              <given-names>P</given-names>
            </name>
          </person-group>
          <article-title>An online survey of young adolescent girls' use of the internet and smartphone apps for mental health support</article-title>
          <source>BJPsych Open</source>
          <year>2018</year>
          <month>07</month>
          <volume>4</volume>
          <issue>4</issue>
          <fpage>302</fpage>
          <lpage>6</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/30083383"/>
          </comment>
          <pub-id pub-id-type="doi">10.1192/bjo.2018.43</pub-id>
          <pub-id pub-id-type="medline">30083383</pub-id>
          <pub-id pub-id-type="pii">00043</pub-id>
          <pub-id pub-id-type="pmcid">PMC6066993</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref119">
        <label>119</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Teaford</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Goyal</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>McNeish</surname>
              <given-names>SG</given-names>
            </name>
          </person-group>
          <article-title>Identification of postpartum depression in an online community</article-title>
          <source>J Obstet Gynecol Neonatal Nurs</source>
          <year>2015</year>
          <volume>44</volume>
          <issue>5</issue>
          <fpage>578</fpage>
          <lpage>86</lpage>
          <pub-id pub-id-type="doi">10.1111/1552-6909.12740</pub-id>
          <pub-id pub-id-type="medline">26285029</pub-id>
          <pub-id pub-id-type="pii">S0884-2175(15)35306-5</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref120">
        <label>120</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Wright</surname>
              <given-names>KB</given-names>
            </name>
            <name name-style="western">
              <surname>Rosenberg</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Egbert</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Ploeger</surname>
              <given-names>NA</given-names>
            </name>
            <name name-style="western">
              <surname>Bernard</surname>
              <given-names>DR</given-names>
            </name>
            <name name-style="western">
              <surname>King</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Communication competence, social support, and depression among college students: a model of facebook and face-to-face support network influence</article-title>
          <source>J Health Commun</source>
          <year>2013</year>
          <volume>18</volume>
          <issue>1</issue>
          <fpage>41</fpage>
          <lpage>57</lpage>
          <pub-id pub-id-type="doi">10.1080/10810730.2012.688250</pub-id>
          <pub-id pub-id-type="medline">23030518</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref121">
        <label>121</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Carpenter</surname>
              <given-names>JS</given-names>
            </name>
            <name name-style="western">
              <surname>Andrykowski</surname>
              <given-names>MA</given-names>
            </name>
            <name name-style="western">
              <surname>Wilson</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Hall</surname>
              <given-names>LA</given-names>
            </name>
            <name name-style="western">
              <surname>Rayens</surname>
              <given-names>MK</given-names>
            </name>
            <name name-style="western">
              <surname>Sachs</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Cunningham</surname>
              <given-names>LL</given-names>
            </name>
          </person-group>
          <article-title>Psychometrics for two short forms of the Center for Epidemiologic Studies-Depression Scale</article-title>
          <source>Issues Ment Health Nurs</source>
          <year>1998</year>
          <volume>19</volume>
          <issue>5</issue>
          <fpage>481</fpage>
          <lpage>94</lpage>
          <pub-id pub-id-type="doi">10.1080/016128498248917</pub-id>
          <pub-id pub-id-type="medline">9782864</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref122">
        <label>122</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Batenburg</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Das</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>Emotional coping differences among breast cancer patients from an online support group: a cross-sectional study</article-title>
          <source>J Med Internet Res</source>
          <year>2014</year>
          <month>02</month>
          <day>05</day>
          <volume>16</volume>
          <issue>2</issue>
          <fpage>e28</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2014/2/e28/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.2831</pub-id>
          <pub-id pub-id-type="medline">24499687</pub-id>
          <pub-id pub-id-type="pii">v16i2e28</pub-id>
          <pub-id pub-id-type="pmcid">PMC3936302</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref123">
        <label>123</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kobori</surname>
              <given-names>O</given-names>
            </name>
            <name name-style="western">
              <surname>Yoshinaga</surname>
              <given-names>N</given-names>
            </name>
          </person-group>
          <article-title>Investigation of the effects of an online support group for mental health problems on stigma and help-seeking among Japanese adults: cross-sectional study</article-title>
          <source>JMIR Form Res</source>
          <year>2021</year>
          <month>09</month>
          <day>07</day>
          <volume>5</volume>
          <issue>9</issue>
          <fpage>e21348</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://formative.jmir.org/2021/9/e21348/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/21348</pub-id>
          <pub-id pub-id-type="medline">34491206</pub-id>
          <pub-id pub-id-type="pii">v5i9e21348</pub-id>
          <pub-id pub-id-type="pmcid">PMC8456335</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref124">
        <label>124</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Frison</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Eggermont</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>The impact of daily stress on adolescents’ depressed mood: the role of social support seeking through Facebook</article-title>
          <source>Comput Human Behav</source>
          <year>2015</year>
          <month>03</month>
          <volume>44</volume>
          <fpage>315</fpage>
          <lpage>25</lpage>
          <pub-id pub-id-type="doi">10.1016/j.chb.2014.11.070</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref125">
        <label>125</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chou</surname>
              <given-names>WY</given-names>
            </name>
            <name name-style="western">
              <surname>Hunt</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Folkers</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Augustson</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>Cancer survivorship in the age of YouTube and social media: a narrative analysis</article-title>
          <source>J Med Internet Res</source>
          <year>2011</year>
          <month>01</month>
          <day>17</day>
          <volume>13</volume>
          <issue>1</issue>
          <fpage>e7</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2011/1/e7/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.1569</pub-id>
          <pub-id pub-id-type="medline">21247864</pub-id>
          <pub-id pub-id-type="pii">v13i1e7</pub-id>
          <pub-id pub-id-type="pmcid">PMC3221357</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref126">
        <label>126</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chung</surname>
              <given-names>JE</given-names>
            </name>
          </person-group>
          <article-title>Social networking in online support groups for health: how online social networking benefits patients</article-title>
          <source>J Health Commun</source>
          <year>2014</year>
          <volume>19</volume>
          <issue>6</issue>
          <fpage>639</fpage>
          <lpage>59</lpage>
          <pub-id pub-id-type="doi">10.1080/10810730.2012.757396</pub-id>
          <pub-id pub-id-type="medline">23557148</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref127">
        <label>127</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Curtis</surname>
              <given-names>BL</given-names>
            </name>
            <name name-style="western">
              <surname>Ashford</surname>
              <given-names>RD</given-names>
            </name>
            <name name-style="western">
              <surname>Magnuson</surname>
              <given-names>KI</given-names>
            </name>
            <name name-style="western">
              <surname>Ryan-Pettes</surname>
              <given-names>SR</given-names>
            </name>
          </person-group>
          <article-title>Comparison of smartphone ownership, social media use, and willingness to use digital interventions between generation Z and millennials in the treatment of substance use: cross-sectional questionnaire study</article-title>
          <source>J Med Internet Res</source>
          <year>2019</year>
          <month>04</month>
          <day>17</day>
          <volume>21</volume>
          <issue>4</issue>
          <fpage>e13050</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2019/4/e13050/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/13050</pub-id>
          <pub-id pub-id-type="medline">30994464</pub-id>
          <pub-id pub-id-type="pii">v21i4e13050</pub-id>
          <pub-id pub-id-type="pmcid">PMC6492066</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref128">
        <label>128</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Bell</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Mok</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Gardiner</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Pirkis</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>Suicide-related internet use among suicidal young people in the UK: characteristics of users, effects of use, and barriers to offline help-seeking</article-title>
          <source>Arch Suicide Res</source>
          <year>2018</year>
          <volume>22</volume>
          <issue>2</issue>
          <fpage>263</fpage>
          <lpage>77</lpage>
          <pub-id pub-id-type="doi">10.1080/13811118.2017.1334609</pub-id>
          <pub-id pub-id-type="medline">28590842</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref129">
        <label>129</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Han</surname>
              <given-names>JY</given-names>
            </name>
            <name name-style="western">
              <surname>Hou</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Gustafson</surname>
              <given-names>DH</given-names>
            </name>
          </person-group>
          <article-title>Lurking as an active participation process: a longitudinal investigation of engagement with an online cancer support group</article-title>
          <source>Health Commun</source>
          <year>2014</year>
          <volume>29</volume>
          <issue>9</issue>
          <fpage>911</fpage>
          <lpage>23</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/24345206"/>
          </comment>
          <pub-id pub-id-type="doi">10.1080/10410236.2013.816911</pub-id>
          <pub-id pub-id-type="medline">24345206</pub-id>
          <pub-id pub-id-type="pmcid">PMC4469645</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref130">
        <label>130</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Petrovčič</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Petrič</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Differences in intrapersonal and interactional empowerment between lurkers and posters in health-related online support communities</article-title>
          <source>Comput Human Behav</source>
          <year>2014</year>
          <month>05</month>
          <volume>34</volume>
          <fpage>39</fpage>
          <lpage>48</lpage>
          <pub-id pub-id-type="doi">10.1016/j.chb.2014.01.008</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref131">
        <label>131</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Setoyama</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Yamazaki</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Namayama</surname>
              <given-names>K</given-names>
            </name>
          </person-group>
          <article-title>Benefits of peer support in online Japanese breast cancer communities: differences between lurkers and posters</article-title>
          <source>J Med Internet Res</source>
          <year>2011</year>
          <month>12</month>
          <day>29</day>
          <volume>13</volume>
          <issue>4</issue>
          <fpage>e122</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2011/4/e122/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.1696</pub-id>
          <pub-id pub-id-type="medline">22204869</pub-id>
          <pub-id pub-id-type="pii">v13i4e122</pub-id>
          <pub-id pub-id-type="pmcid">PMC3278108</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref132">
        <label>132</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Neary</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Schueller</surname>
              <given-names>SM</given-names>
            </name>
          </person-group>
          <article-title>State of the field of mental health apps</article-title>
          <source>Cogn Behav Pract</source>
          <year>2018</year>
          <month>11</month>
          <volume>25</volume>
          <issue>4</issue>
          <fpage>531</fpage>
          <lpage>7</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/33100810"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.cbpra.2018.01.002</pub-id>
          <pub-id pub-id-type="medline">33100810</pub-id>
          <pub-id pub-id-type="pmcid">PMC7584258</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref133">
        <label>133</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Forsman</surname>
              <given-names>AK</given-names>
            </name>
            <name name-style="western">
              <surname>Nordmyr</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>Psychosocial links between internet use and mental health in later life: a systematic review of quantitative and qualitative evidence</article-title>
          <source>J Appl Gerontol</source>
          <year>2017</year>
          <month>12</month>
          <volume>36</volume>
          <issue>12</issue>
          <fpage>1471</fpage>
          <lpage>518</lpage>
          <pub-id pub-id-type="doi">10.1177/0733464815595509</pub-id>
          <pub-id pub-id-type="medline">26245208</pub-id>
          <pub-id pub-id-type="pii">0733464815595509</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref134">
        <label>134</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Johansson</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Islind</surname>
              <given-names>AS</given-names>
            </name>
            <name name-style="western">
              <surname>Lindroth</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Angenete</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Gellerstedt</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Online communities as a driver for patient empowerment: systematic review</article-title>
          <source>J Med Internet Res</source>
          <year>2021</year>
          <month>02</month>
          <day>09</day>
          <volume>23</volume>
          <issue>2</issue>
          <fpage>e19910</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2021/2/e19910/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/19910</pub-id>
          <pub-id pub-id-type="medline">33560233</pub-id>
          <pub-id pub-id-type="pii">v23i2e19910</pub-id>
          <pub-id pub-id-type="pmcid">PMC7902187</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref135">
        <label>135</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Barr</surname>
              <given-names>PJ</given-names>
            </name>
            <name name-style="western">
              <surname>Scholl</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>Bravo</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Faber</surname>
              <given-names>MJ</given-names>
            </name>
            <name name-style="western">
              <surname>Elwyn</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>McAllister</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Assessment of patient empowerment--a systematic review of measures</article-title>
          <source>PLoS One</source>
          <year>2015</year>
          <month>5</month>
          <day>13</day>
          <volume>10</volume>
          <issue>5</issue>
          <fpage>e0126553</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://dx.plos.org/10.1371/journal.pone.0126553"/>
          </comment>
          <pub-id pub-id-type="doi">10.1371/journal.pone.0126553</pub-id>
          <pub-id pub-id-type="medline">25970618</pub-id>
          <pub-id pub-id-type="pii">PONE-D-14-21091</pub-id>
          <pub-id pub-id-type="pmcid">PMC4430483</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref136">
        <label>136</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Náfrádi</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Nakamoto</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Schulz</surname>
              <given-names>PJ</given-names>
            </name>
          </person-group>
          <article-title>Is patient empowerment the key to promote adherence? A systematic review of the relationship between self-efficacy, health locus of control and medication adherence</article-title>
          <source>PLoS One</source>
          <year>2017</year>
          <month>10</month>
          <day>17</day>
          <volume>12</volume>
          <issue>10</issue>
          <fpage>e0186458</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://dx.plos.org/10.1371/journal.pone.0186458"/>
          </comment>
          <pub-id pub-id-type="doi">10.1371/journal.pone.0186458</pub-id>
          <pub-id pub-id-type="medline">29040335</pub-id>
          <pub-id pub-id-type="pii">PONE-D-16-38852</pub-id>
          <pub-id pub-id-type="pmcid">PMC5645121</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref137">
        <label>137</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Wallerstein</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Oetzel</surname>
              <given-names>JG</given-names>
            </name>
            <name name-style="western">
              <surname>Sanchez-Youngman</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Boursaw</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Dickson</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Kastelic</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Koegel</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Lucero</surname>
              <given-names>JE</given-names>
            </name>
            <name name-style="western">
              <surname>Magarati</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Ortiz</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Parker</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Peña</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Richmond</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Duran</surname>
              <given-names>B</given-names>
            </name>
          </person-group>
          <article-title>Engage for Equity: a long-term study of community-based participatory research and community-engaged research practices and outcomes</article-title>
          <source>Health Educ Behav</source>
          <year>2020</year>
          <month>06</month>
          <volume>47</volume>
          <issue>3</issue>
          <fpage>380</fpage>
          <lpage>90</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/32437293"/>
          </comment>
          <pub-id pub-id-type="doi">10.1177/1090198119897075</pub-id>
          <pub-id pub-id-type="medline">32437293</pub-id>
          <pub-id pub-id-type="pmcid">PMC8093095</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref138">
        <label>138</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Anderson</surname>
              <given-names>B</given-names>
            </name>
          </person-group>
          <article-title>Collaborative care and motivational interviewing: improving depression outcomes through patient empowerment interventions</article-title>
          <source>Am J Manag Care</source>
          <year>2007</year>
          <month>11</month>
          <volume>13</volume>
          <issue>4 Suppl</issue>
          <fpage>S103</fpage>
          <lpage>6</lpage>
          <pub-id pub-id-type="medline">18041866</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref139">
        <label>139</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lorig</surname>
              <given-names>KR</given-names>
            </name>
            <name name-style="western">
              <surname>Holman</surname>
              <given-names>HR</given-names>
            </name>
          </person-group>
          <article-title>Self-management education: history, definition, outcomes, and mechanisms</article-title>
          <source>Ann Behav Med</source>
          <year>2003</year>
          <month>08</month>
          <volume>26</volume>
          <issue>1</issue>
          <fpage>1</fpage>
          <lpage>7</lpage>
          <pub-id pub-id-type="doi">10.1207/S15324796ABM2601_01</pub-id>
          <pub-id pub-id-type="medline">12867348</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref140">
        <label>140</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Audrain-Pontevia</surname>
              <given-names>AF</given-names>
            </name>
            <name name-style="western">
              <surname>Menvielle</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>Do online health communities enhance patient-physician relationship? An assessment of the impact of social support and patient empowerment</article-title>
          <source>Health Serv Manage Res</source>
          <year>2018</year>
          <month>08</month>
          <volume>31</volume>
          <issue>3</issue>
          <fpage>154</fpage>
          <lpage>62</lpage>
          <pub-id pub-id-type="doi">10.1177/0951484817748462</pub-id>
          <pub-id pub-id-type="medline">29280679</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref141">
        <label>141</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>McAllister</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Dunn</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Payne</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Davies</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Todd</surname>
              <given-names>C</given-names>
            </name>
          </person-group>
          <article-title>Patient empowerment: the need to consider it as a measurable patient-reported outcome for chronic conditions</article-title>
          <source>BMC Health Serv Res</source>
          <year>2012</year>
          <month>06</month>
          <day>13</day>
          <volume>12</volume>
          <fpage>157</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmchealthservres.biomedcentral.com/articles/10.1186/1472-6963-12-157"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/1472-6963-12-157</pub-id>
          <pub-id pub-id-type="medline">22694747</pub-id>
          <pub-id pub-id-type="pii">1472-6963-12-157</pub-id>
          <pub-id pub-id-type="pmcid">PMC3457855</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref142">
        <label>142</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Camerini</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Schulz</surname>
              <given-names>PJ</given-names>
            </name>
          </person-group>
          <article-title>Effects of functional interactivity on patients' knowledge, empowerment, and health outcomes: an experimental model-driven evaluation of a web-based intervention</article-title>
          <source>J Med Internet Res</source>
          <year>2012</year>
          <month>07</month>
          <day>18</day>
          <volume>14</volume>
          <issue>4</issue>
          <fpage>e105</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2012/4/e105/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.1953</pub-id>
          <pub-id pub-id-type="medline">22810046</pub-id>
          <pub-id pub-id-type="pii">v14i4e105</pub-id>
          <pub-id pub-id-type="pmcid">PMC3409610</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref143">
        <label>143</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Starcevic</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Berle</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Arnáez</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Recent insights into cyberchondria</article-title>
          <source>Curr Psychiatry Rep</source>
          <year>2020</year>
          <month>08</month>
          <day>27</day>
          <volume>22</volume>
          <issue>11</issue>
          <fpage>56</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/32852626"/>
          </comment>
          <pub-id pub-id-type="doi">10.1007/s11920-020-01179-8</pub-id>
          <pub-id pub-id-type="medline">32852626</pub-id>
          <pub-id pub-id-type="pii">10.1007/s11920-020-01179-8</pub-id>
          <pub-id pub-id-type="pmcid">PMC7450158</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref144">
        <label>144</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Han</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Zhan</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Li</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Xu</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Xu</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Zhao</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>Associations between the perceived severity of the COVID-19 pandemic, cyberchondria, depression, anxiety, stress, and lockdown experience: cross-sectional survey study</article-title>
          <source>JMIR Public Health Surveill</source>
          <year>2021</year>
          <month>09</month>
          <day>16</day>
          <volume>7</volume>
          <issue>9</issue>
          <fpage>e31052</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://publichealth.jmir.org/2021/9/e31052/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/31052</pub-id>
          <pub-id pub-id-type="medline">34478402</pub-id>
          <pub-id pub-id-type="pii">v7i9e31052</pub-id>
          <pub-id pub-id-type="pmcid">PMC8448083</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref145">
        <label>145</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Yousaf</surname>
              <given-names>O</given-names>
            </name>
            <name name-style="western">
              <surname>Grunfeld</surname>
              <given-names>EA</given-names>
            </name>
            <name name-style="western">
              <surname>Hunter</surname>
              <given-names>MS</given-names>
            </name>
          </person-group>
          <article-title>A systematic review of the factors associated with delays in medical and psychological help-seeking among men</article-title>
          <source>Health Psychol Rev</source>
          <year>2015</year>
          <volume>9</volume>
          <issue>2</issue>
          <fpage>264</fpage>
          <lpage>76</lpage>
          <pub-id pub-id-type="doi">10.1080/17437199.2013.840954</pub-id>
          <pub-id pub-id-type="medline">26209212</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref146">
        <label>146</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Hirschfeld</surname>
              <given-names>RM</given-names>
            </name>
          </person-group>
          <article-title>The comorbidity of major depression and anxiety disorders: recognition and management in primary care</article-title>
          <source>Prim Care Companion J Clin Psychiatry</source>
          <year>2001</year>
          <month>12</month>
          <volume>3</volume>
          <issue>6</issue>
          <fpage>244</fpage>
          <lpage>54</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/15014592"/>
          </comment>
          <pub-id pub-id-type="doi">10.4088/pcc.v03n0609</pub-id>
          <pub-id pub-id-type="medline">15014592</pub-id>
          <pub-id pub-id-type="pmcid">PMC181193</pub-id>
        </nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
