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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v24i8e34229</article-id>
      <article-id pub-id-type="pmid">36001380</article-id>
      <article-id pub-id-type="doi">10.2196/34229</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>The Barriers and Facilitators of eHealth-Based Lifestyle Intervention Programs for People With a Low Socioeconomic Status: Scoping Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Mavragani</surname>
            <given-names>Amaryllis</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Mehdizadeh</surname>
            <given-names>Hamed</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Porter</surname>
            <given-names>Gwenndolyn</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Velayati</surname>
            <given-names>Farnia</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Ayatollahi</surname>
            <given-names>Haleh</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes" equal-contrib="yes">
          <name name-style="western">
            <surname>Al-Dhahir</surname>
            <given-names>Isra</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff01" ref-type="aff">1</xref>
          <address>
            <institution>Faculty of Social and Behavioral Sciences</institution>
            <institution>Health, Medical and Neuropsychology Unit</institution>
            <institution>Leiden University</institution>
            <addr-line>Wassenaarseweg 52</addr-line>
            <addr-line>Leiden, 2333 AK</addr-line>
            <country>Netherlands</country>
            <phone>31 715273627</phone>
            <email>i.al-dhahir@fsw.leidenuniv.nl</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-8510-3313</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Reijnders</surname>
            <given-names>Thomas</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff01" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-2184-8727</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Faber</surname>
            <given-names>Jasper S</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff02" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-0380-0989</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>van den Berg-Emons</surname>
            <given-names>Rita J</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff03" ref-type="aff">3</xref>
          <xref rid="aff04" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-6433-3398</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Janssen</surname>
            <given-names>Veronica R</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff01" ref-type="aff">1</xref>
          <xref rid="aff05" ref-type="aff">5</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-4113-6716</ext-link>
        </contrib>
        <contrib id="contrib6" contrib-type="author">
          <name name-style="western">
            <surname>Kraaijenhagen</surname>
            <given-names>Roderik A</given-names>
          </name>
          <degrees>MD, PhD</degrees>
          <xref rid="aff06" ref-type="aff">6</xref>
          <xref rid="aff07" ref-type="aff">7</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-5102-0197</ext-link>
        </contrib>
        <contrib id="contrib7" contrib-type="author">
          <name name-style="western">
            <surname>Visch</surname>
            <given-names>Valentijn T</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff02" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-5502-1691</ext-link>
        </contrib>
        <contrib id="contrib8" contrib-type="author">
          <name name-style="western">
            <surname>Chavannes</surname>
            <given-names>Niels H</given-names>
          </name>
          <degrees>MD, Prof Dr</degrees>
          <xref rid="aff08" ref-type="aff">8</xref>
          <xref rid="aff09" ref-type="aff">9</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-8607-9199</ext-link>
        </contrib>
        <contrib id="contrib9" contrib-type="author">
          <name name-style="western">
            <surname>Evers</surname>
            <given-names>Andrea W M</given-names>
          </name>
          <degrees>Prof Dr</degrees>
          <xref rid="aff01" ref-type="aff">1</xref>
          <xref rid="aff10" ref-type="aff">10</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-0090-5091</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff01">
        <label>1</label>
        <institution>Faculty of Social and Behavioral Sciences</institution>
        <institution>Health, Medical and Neuropsychology Unit</institution>
        <institution>Leiden University</institution>
        <addr-line>Leiden</addr-line>
        <country>Netherlands</country>
      </aff>
      <aff id="aff02">
        <label>2</label>
        <institution>Faculty of Industrial Design Engineering</institution>
        <institution>Delft University of Technology</institution>
        <addr-line>Delft</addr-line>
        <country>Netherlands</country>
      </aff>
      <aff id="aff03">
        <label>3</label>
        <institution>Department of Rehabilitation Medicine</institution>
        <institution>Erasmus University Medical Centre</institution>
        <addr-line>Rotterdam</addr-line>
        <country>Netherlands</country>
      </aff>
      <aff id="aff04">
        <label>4</label>
        <institution>Capri Cardiac Rehabilitation</institution>
        <addr-line>Rotterdam</addr-line>
        <country>Netherlands</country>
      </aff>
      <aff id="aff05">
        <label>5</label>
        <institution>Department of Cardiology</institution>
        <institution>Leiden University Medical Center</institution>
        <addr-line>Leiden</addr-line>
        <country>Netherlands</country>
      </aff>
      <aff id="aff06">
        <label>6</label>
        <institution>Vital10</institution>
        <addr-line>Amsterdam</addr-line>
        <country>Netherlands</country>
      </aff>
      <aff id="aff07">
        <label>7</label>
        <institution>NDDO Institute for Prevention and Early Diagnostics (NIPED)</institution>
        <addr-line>Amsterdam</addr-line>
        <country>Netherlands</country>
      </aff>
      <aff id="aff08">
        <label>8</label>
        <institution>Department of Public Health and Primary Care</institution>
        <institution>Leiden University Medical Center</institution>
        <addr-line>Leiden</addr-line>
        <country>Netherlands</country>
      </aff>
      <aff id="aff09">
        <label>9</label>
        <institution>National eHealth Living Lab</institution>
        <institution>Leiden University Medical Centre</institution>
        <addr-line>Leiden</addr-line>
        <country>Netherlands</country>
      </aff>
      <aff id="aff10">
        <label>10</label>
        <institution>Medical Delta</institution>
        <institution>Leiden University, Delft University of Technology, Erasmus University</institution>
        <addr-line>Delft</addr-line>
        <country>Netherlands</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Isra Al-Dhahir <email>i.al-dhahir@fsw.leidenuniv.nl</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <month>8</month>
        <year>2022</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>24</day>
        <month>8</month>
        <year>2022</year>
      </pub-date>
      <volume>24</volume>
      <issue>8</issue>
      <elocation-id>e34229</elocation-id>
      <history>
        <date date-type="received">
          <day>13</day>
          <month>10</month>
          <year>2021</year>
        </date>
        <date date-type="rev-request">
          <day>28</day>
          <month>12</month>
          <year>2021</year>
        </date>
        <date date-type="rev-recd">
          <day>24</day>
          <month>3</month>
          <year>2022</year>
        </date>
        <date date-type="accepted">
          <day>31</day>
          <month>3</month>
          <year>2022</year>
        </date>
      </history>
      <copyright-statement>©Isra Al-Dhahir, Thomas Reijnders, Jasper S Faber, Rita J van den Berg-Emons, Veronica R Janssen, Roderik A Kraaijenhagen, Valentijn T Visch, Niels H Chavannes, Andrea W M Evers. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 24.08.2022.</copyright-statement>
      <copyright-year>2022</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://www.jmir.org/2022/8/e34229" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>Promoting health behaviors and preventing chronic diseases through a healthy lifestyle among those with a low socioeconomic status (SES) remain major challenges. eHealth interventions are a promising approach to change unhealthy behaviors in this target group.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This review aims to identify key components, barriers, and facilitators in the development, reach, use, evaluation, and implementation of eHealth lifestyle interventions for people with a low SES. This review provides an overview for researchers and eHealth developers, and can assist in the development of eHealth interventions for people with a low SES.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>We performed a scoping review based on Arksey and O’Malley’s framework. A systematic search was conducted on PubMed, MEDLINE (Ovid), Embase, Web of Science, and the Cochrane Library, using terms related to a combination of the following key constructs: eHealth, lifestyle, low SES, development, reach, use, evaluation, and implementation. There were no restrictions on the date of publication for articles retrieved upon searching the databases.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>The search identified 1323 studies, of which 42 met our inclusion criteria. An update of the search led to the inclusion of 17 additional studies. eHealth lifestyle interventions for people with a low SES were often delivered via internet-based methods (eg, websites, email, Facebook, and smartphone apps) and offline methods, such as texting. A minority of the interventions combined eHealth lifestyle interventions with face-to-face or telephone coaching, or wearables (blended care). We identified the use of different behavioral components (eg, social support) and technological components (eg, multimedia) in eHealth lifestyle interventions. Facilitators in the development included iterative design, working with different disciplines, and resonating intervention content with users. Facilitators for intervention reach were use of a personal approach and social network, reminders, and self-monitoring. Nevertheless, barriers, such as technological challenges for developers and limited financial resources, may hinder intervention development. Furthermore, passive recruitment was a barrier to intervention reach. Technical difficulties and the use of self-monitoring devices were common barriers for users of eHealth interventions. Only limited data on barriers and facilitators for intervention implementation and evaluation were available.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>While we found large variations among studies regarding key intervention components, and barriers and facilitators, certain factors may be beneficial in building and using eHealth interventions and reaching people with a low SES. Barriers and facilitators offer promising elements that eHealth developers can use as a toolbox to connect eHealth with low SES individuals. Our findings suggest that one-size-fits-all eHealth interventions may be less suitable for people with a low SES. Future research should investigate how to customize eHealth lifestyle interventions to meet the needs of different low SES groups, and should identify the components that enhance their reach, use, and effectiveness.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>eHealth</kwd>
        <kwd>lifestyle interventions</kwd>
        <kwd>health behaviors</kwd>
        <kwd>low socioeconomic status</kwd>
        <kwd>intervention development</kwd>
        <kwd>barriers</kwd>
        <kwd>facilitators</kwd>
        <kwd>prevention</kwd>
        <kwd>intervention evaluation</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <p>Chronic diseases, such as cardiovascular disease and type 2 diabetes, accounted for 74% of deaths globally in 2019 [<xref ref-type="bibr" rid="ref1">1</xref>]. These diseases are often preventable and treatable. Adopting a healthy lifestyle, such as smoking cessation, increased physical activity, a balanced diet, and decreased alcohol consumption, can reduce the risk of developing a chronic disease [<xref ref-type="bibr" rid="ref2">2</xref>]. Traditional lifestyle interventions have been shown to be effective in helping people adopt a healthy lifestyle [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>]. However, these interventions mostly focus on the general population and often disregard vulnerable groups, such as those with a low socioeconomic status (SES; people with a low income or low education, or who are from deprived neighborhoods). There is firm evidence that people with a low SES often engage in more risky lifestyle behaviors and have an increased risk for various chronic diseases and premature death than those with a high SES [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref5">5</xref>-<xref ref-type="bibr" rid="ref7">7</xref>]. Health inequalities for low SES are associated with a reduced life expectancy of 5 to 10 years and a reduced disability-free life expectancy of 10 to 20 years [<xref ref-type="bibr" rid="ref8">8</xref>]. Furthermore, it seems that low income and poverty are more often associated with poorer mental health [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref10">10</xref>]. A systematic review by Bull et al [<xref ref-type="bibr" rid="ref11">11</xref>] found that when lifestyle interventions focus on people with a low SES, most result in small and variable effects [<xref ref-type="bibr" rid="ref11">11</xref>]. These findings may be due to designers not tailoring lifestyle interventions specifically to people with a low SES or not taking into account their specific characteristics and needs [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref13">13</xref>]. For instance, compared to the general population, individuals with a low SES living in poverty may focus more on coping with their current stressful everyday life (ie, money-related stress and unfavorable work environment). These stressors can lead to choosing unhealthy coping strategies, such as tobacco smoking [<xref ref-type="bibr" rid="ref14">14</xref>], which could be detrimental to long-term health [<xref ref-type="bibr" rid="ref14">14</xref>]. These challenges call for a different approach to help this priority group adopt and maintain a healthy lifestyle.</p>
      <p>eHealth interventions could proactively support people with a low SES to adopt lifestyle changes [<xref ref-type="bibr" rid="ref15">15</xref>]. The use of the latest information and communication technologies, such as websites, smartphones, email, text messaging, tablets, and smartwatches [<xref ref-type="bibr" rid="ref16">16</xref>], offers health professionals and researchers more options to tailor intervention content to the specific needs and characteristics of the user [<xref ref-type="bibr" rid="ref17">17</xref>]. Furthermore, eHealth interventions can provide users with the information, skills, and resources needed for a positive lifestyle change efficiently and interactively [<xref ref-type="bibr" rid="ref18">18</xref>]. Health practitioners can reach diverse populations more easily with these interventions than with traditional interventions [<xref ref-type="bibr" rid="ref18">18</xref>]. eHealth interventions can be supported by video or audio and delivered in an accessible manner to patients for use in their own time and home environment [<xref ref-type="bibr" rid="ref19">19</xref>]. However, current eHealth interventions require users to have good digital skills and a high literacy level, which are often lacking in low SES groups. Moreover, such interventions must consider their different life situations, health care needs, and eHealth expectations [<xref ref-type="bibr" rid="ref20">20</xref>]. When eHealth interventions do not consider the needs of this target group, intervention uptake can hinder and reinforce the inequitable use of eHealth, exacerbating health inequalities [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref22">22</xref>].</p>
      <p>Studies have shown promising results for eHealth among people with a low SES [<xref ref-type="bibr" rid="ref23">23</xref>]. For instance, Brown et al [<xref ref-type="bibr" rid="ref23">23</xref>] showed that their eHealth lifestyle intervention for low SES individuals yielded small but significant changes in behavior. Hayba et al [<xref ref-type="bibr" rid="ref24">24</xref>] suggested that even modestly effective interventions, sustainably deployed to target vulnerable groups (eg, low SES groups), would add value to the field of public health. Even though there is a growing body of research on eHealth lifestyle interventions for this vulnerable group, there is a lack of insight into how eHealth interventions are currently developed, used, and implemented for people with a low SES. Recently, there has been an increased focus on the specific needs and characteristics of low SES groups to bridge this digital divide. For example, the World Health Organization’s digital intervention guidelines for eHealth usage to improve patient care devoted special attention to the needs, preferences, and circumstances of vulnerable groups, such as people with low (digital) literacy skills [<xref ref-type="bibr" rid="ref25">25</xref>]. However, current guidelines fall short for researchers and developers who want to develop eHealth lifestyle interventions tailored to people with a low SES. Therefore, this scoping review aims to identify intervention components, barriers, and facilitators in the development, reach, use, evaluation, and implementation of existing eHealth lifestyle interventions for low SES populations.</p>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Scoping Review Methodology</title>
        <p>We conducted a systematic scoping review from June to September 2019. In July 2021, we updated the search following the same procedures. There were no restrictions on the date of publication for articles retrieved upon searching the databases. Since the research area of eHealth lifestyle interventions for low SES groups is still in its infancy, a scoping review method was chosen because it is an appropriate methodology to map key concepts and identify knowledge gaps. A scoping review also offers the opportunity to review published literature with different methodological designs. It further examines the existing literature concerning the volume, nature, and characteristics of the primary research [<xref ref-type="bibr" rid="ref26">26</xref>]. We used Arksey and O’Malley’s methodological framework as a guide for the review [<xref ref-type="bibr" rid="ref26">26</xref>].</p>
      </sec>
      <sec>
        <title>Search Strategy and Eligibility Criteria</title>
        <p>We defined the following 5 categories based on 2 frameworks used for the development process of eHealth interventions: development, reach, use, evaluation, and implementation [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref28">28</xref>]. The first framework is the Center for eHealth Research (CeHRes) roadmap, a framework for eHealth development, implementation, and evaluation that combines and uses aspects from approaches like human-centered design, persuasive technology, and business modeling [<xref ref-type="bibr" rid="ref27">27</xref>]. The second framework is RE-AIM (reach, effectiveness, adoption, implementation, and maintenance), which describes the stages in intervention development and implementation [<xref ref-type="bibr" rid="ref28">28</xref>]. The categories <italic>development</italic>, <italic>use</italic>, and <italic>evaluation</italic> were derived from the CeHRes roadmap, and the categories <italic>reach</italic> and <italic>implementation</italic> were derived from the RE-AIM framework.</p>
        <p>After we defined the scope of the review, we developed a search strategy together with an experienced librarian and domain experts (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>). We searched PubMed, MEDLINE (Ovid), Embase, Web of Science, and the Cochrane Library, using a combination of the following key constructs: eHealth, lifestyle (physical activity, nutrition, alcohol, smoking, and sleep), low SES, and development, reach, use, evaluation, and implementation. The definitions of these key constructs are provided in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>. These databases were chosen because they cover a wide range of scientific articles on eHealth. For each construct, several keywords (spelling variations and synonyms) were used. Exclusion and inclusion criteria were defined based on relevant literature and in consultation with domain experts, after which relevant studies were selected (<xref ref-type="boxed-text" rid="box1">Textbox 1</xref>).</p>
        <boxed-text id="box1" position="float">
          <title>Inclusion and exclusion criteria for selecting the studies.</title>
          <p>
            <bold>Inclusion criteria</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Description of an eHealth/web-based intervention or mHealth/telemedicine intervention</p>
            </list-item>
            <list-item>
              <p>Definition of socioeconomic status (SES) as the position of an individual on a socioeconomic scale that measures factors by a single variable, such as education, income, or neighborhood status, or multiple variables</p>
            </list-item>
            <list-item>
              <p>Focus on at least one lifestyle component (physical activity, diet, alcohol, smoking, sleep, or overweight)</p>
            </list-item>
            <list-item>
              <p>Targeting of a low SES population (&#62;18 years of age)</p>
            </list-item>
            <list-item>
              <p>Presentation of information on development, use, reach, evaluation, or implementation</p>
            </list-item>
            <list-item>
              <p>Publication of full text in English</p>
            </list-item>
            <list-item>
              <p>Any study type (included study protocols)</p>
            </list-item>
          </list>
          <p>
            <bold>Exclusion criteria</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Measurement of SES using other variables (eg, race and ethnicity)</p>
            </list-item>
            <list-item>
              <p>Conference abstracts and reviews presenting filtered information, such as systematic reviews, scoping reviews, and narrative reviews</p>
            </list-item>
          </list>
        </boxed-text>
      </sec>
      <sec>
        <title>Data Extraction and Analysis</title>
        <p>The eligibility criteria were used to review the articles. Initially, IA screened the titles and abstracts for the first selection of articles. Then, IA checked the bibliographic reference lists of publications that remained after full-text selection to identify any additional eligible publications. Any doubt about the included studies was discussed with the other authors. We extracted general study characteristics (eg, the year of publication and country), and details on SES, effectiveness, development, reach, use, evaluation, and implementation. Data were extracted as barriers or facilitators if they were related to the development, reach, use, evaluation, or implementation phases of the intervention and they were identified or mentioned as facilitators or barriers by the included studies. Even if the barriers and facilitators were mentioned in one of the included studies, they were eligible for inclusion. If there were uncertainties concerning under which phase the barriers and facilitators fell, they were discussed with the other authors.</p>
        <p>Furthermore, we selected additional categories based on the CONSORT-EHEALTH checklist (V1.6), which provides helpful guidance on what eHealth studies should report [<xref ref-type="bibr" rid="ref29">29</xref>]. These added categories were the (behavioral) theories or models used to develop and evaluate an eHealth intervention. The categories also included the level of human involvement in the intervention (eg, automated or human guidance) during the development, evaluation, and implementation (eg, health professionals and researchers).</p>
        <p>The selected articles were mapped, and data were recorded in Microsoft Excel (<xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref>). Data were synthesized narratively, and the findings were then summarized and grouped into themes as defined by the authors.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Study Selection</title>
        <p>The systematic search across the databases revealed 2083 potentially relevant citations. After removing duplicates (n=765) and screening 1323 titles and abstracts, 72 full-text articles were screened for eligibility. Of these, 42 articles met the eligibility criteria and were included in this review (<xref rid="figure1" ref-type="fig">Figure 1</xref>). The updated search led to 17 articles that were included in this review.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>Flow diagram of the article selection process.</p>
          </caption>
          <graphic xlink:href="jmir_v24i8e34229_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Description of the Included Studies</title>
        <p>The studies included were randomized controlled trials (RCTs) [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref30">30</xref>-<xref ref-type="bibr" rid="ref40">40</xref>], observational studies [<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref56">56</xref>], and design studies [<xref ref-type="bibr" rid="ref57">57</xref>-<xref ref-type="bibr" rid="ref77">77</xref>]. Several RCTs and observational studies evaluated eHealth interventions on health outcomes (eg, BMI, blood pressure, and hemoglobin A<sub>1c</sub>) [<xref ref-type="bibr" rid="ref30">30</xref>, <xref ref-type="bibr" rid="ref34">34</xref>, <xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref37">37</xref>, <xref ref-type="bibr" rid="ref40">40</xref>, <xref ref-type="bibr" rid="ref43">43</xref>, <xref ref-type="bibr" rid="ref45">45</xref>, <xref ref-type="bibr" rid="ref47">47</xref>, <xref ref-type="bibr" rid="ref48">48</xref>, <xref ref-type="bibr" rid="ref53">53</xref>, <xref ref-type="bibr" rid="ref78">78</xref>], nutrition-related behavior outcomes [<xref ref-type="bibr" rid="ref32">32</xref>, <xref ref-type="bibr" rid="ref38">38</xref>, <xref ref-type="bibr" rid="ref39">39</xref>, <xref ref-type="bibr" rid="ref79">79</xref>, <xref ref-type="bibr" rid="ref80">80</xref>], physical activity–related outcomes, smoking-related outcomes [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref82">82</xref>], usage outcomes [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref54">54</xref>], and reach [<xref ref-type="bibr" rid="ref44">44</xref>], as well as feasibility and acceptability outcomes [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref80">80</xref>] (<xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref>). Design studies examined recruitment [<xref ref-type="bibr" rid="ref57">57</xref>], usability, feasibility [<xref ref-type="bibr" rid="ref57">57</xref>-<xref ref-type="bibr" rid="ref65">65</xref>], development, or acceptability of eHealth interventions [<xref ref-type="bibr" rid="ref58">58</xref>-<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref70">70</xref>]. The interventions were aimed at weight loss (n=9), physical activity (n=9), healthy eating (n=11), smoking (n=13), and alcohol use (n=2), and 17 interventions focused on multiple behaviors. The target audience of these interventions was mainly low SES participants; several studies also targeted a highly educated population [<xref ref-type="bibr" rid="ref31">31</xref>-<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref82">82</xref>].</p>
        <p>The different studies assessed the education level [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref30">30</xref>-<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref53">53</xref>-<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref82">82</xref>], occupation [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref67">67</xref>], or income level of the participants [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref74">74</xref>]. In addition, the participants were recruited from a low SES neighborhood (residents who were unemployed, had a low education, or had a financial disadvantage) [<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref64">64</xref>]. A summary of the study characteristics is presented in <xref ref-type="table" rid="table1">Table 1</xref>.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Summary of the study characteristics (N=59).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="210"/>
            <col width="290"/>
            <col width="250"/>
            <col width="250"/>
            <thead>
              <tr valign="top">
                <td>First author, year</td>
                <td>Study design</td>
                <td>Target population</td>
                <td>Type of eHealth technology</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Aguilera [<xref ref-type="bibr" rid="ref83">83</xref>], 2020</td>
                <td>Protocol</td>
                <td>Low income<sup>a</sup></td>
                <td>App (and SMS text messaging)</td>
              </tr>
              <tr valign="top">
                <td>Aldoory [<xref ref-type="bibr" rid="ref71">71</xref>], 2016</td>
                <td>Design</td>
                <td>Low income</td>
                <td>SMS text messaging</td>
              </tr>
              <tr valign="top">
                <td>Athavale [<xref ref-type="bibr" rid="ref72">72</xref>], 2016</td>
                <td>Design (part of RCT<sup>b</sup>)</td>
                <td>Low income<sup>a</sup> </td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Atkinson [<xref ref-type="bibr" rid="ref66">66</xref>], 2009</td>
                <td>Design</td>
                <td>Low income</td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Bond [<xref ref-type="bibr" rid="ref65">65</xref>], 2021</td>
                <td>Design</td>
                <td>Low income<sup>a</sup></td>
                <td>Web-based and SMS text messaging</td>
              </tr>
              <tr valign="top">
                <td>Brown [<xref ref-type="bibr" rid="ref23">23</xref>], 2014</td>
                <td>RCT</td>
                <td>Low SES<sup>c</sup> </td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Griffin [<xref ref-type="bibr" rid="ref48">48</xref>], 2020</td>
                <td>Observational</td>
                <td>Low income</td>
                <td>SMS text messaging</td>
              </tr>
              <tr valign="top">
                <td>Brunette [<xref ref-type="bibr" rid="ref81">81</xref>], 2015</td>
                <td>Quasiexperimental</td>
                <td>Socioeconomically disadvantaged<sup>d</sup></td>
                <td>Web-based (single session)</td>
              </tr>
              <tr valign="top">
                <td>Burner [<xref ref-type="bibr" rid="ref80">80</xref>], 2020</td>
                <td>Quasiexperimental</td>
                <td>Low income<sup>a</sup></td>
                <td>SMS text messaging</td>
              </tr>
              <tr valign="top">
                <td>Carolan-Olah [<xref ref-type="bibr" rid="ref64">64</xref>], 2021</td>
                <td>Design</td>
                <td>Low SES neighborhoods</td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Cavallo [<xref ref-type="bibr" rid="ref47">47</xref>], 2021</td>
                <td>Observational</td>
                <td>Low income</td>
                <td>Social media</td>
              </tr>
              <tr valign="top">
                <td>Lepore [<xref ref-type="bibr" rid="ref49">49</xref>], 2021</td>
                <td>Observational (part of RCT)</td>
                <td>Low income<sup>a</sup></td>
                <td>App</td>
              </tr>
              <tr valign="top">
                <td>Stanczyk [<xref ref-type="bibr" rid="ref31">31</xref>], 2013</td>
                <td>RCT</td>
                <td>Low, middle, and high education</td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Clarke [<xref ref-type="bibr" rid="ref39">39</xref>], 2019</td>
                <td>RCT</td>
                <td>Low income</td>
                <td>App</td>
              </tr>
              <tr valign="top">
                <td>van Dijk [<xref ref-type="bibr" rid="ref84">84</xref>], 2021</td>
                <td>Protocol</td>
                <td>Low SES<sup>a</sup></td>
                <td>Web-based on smartphone</td>
              </tr>
              <tr valign="top">
                <td>Brown [<xref ref-type="bibr" rid="ref46">46</xref>], 2012</td>
                <td>Observational</td>
                <td>Low SES<sup>c</sup></td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Evans [<xref ref-type="bibr" rid="ref62">62</xref>], 2019</td>
                <td>Design</td>
                <td>Low income</td>
                <td>App</td>
              </tr>
              <tr valign="top">
                <td>Flaherty [<xref ref-type="bibr" rid="ref67">67</xref>], 2020</td>
                <td>Design</td>
                <td>Low SES<sup>e</sup></td>
                <td>App</td>
              </tr>
              <tr valign="top">
                <td>Delrahim-Howlett [<xref ref-type="bibr" rid="ref38">38</xref>], 2011</td>
                <td>RCT</td>
                <td>Low income</td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Fontil [<xref ref-type="bibr" rid="ref61">61</xref>], 2016</td>
                <td>Design</td>
                <td>Low income</td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Garvin [<xref ref-type="bibr" rid="ref73">73</xref>], 2019</td>
                <td>Design</td>
                <td>Low income</td>
                <td>App</td>
              </tr>
              <tr valign="top">
                <td>Golsteijn [<xref ref-type="bibr" rid="ref85">85</xref>], 2017</td>
                <td>Protocol</td>
                <td>Low, middle, and high education</td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Foley [<xref ref-type="bibr" rid="ref37">37</xref>], 2016</td>
                <td>RCT</td>
                <td>Socioeconomically disadvantaged</td>
                <td>SMS text messaging</td>
              </tr>
              <tr valign="top">
                <td>Greene [<xref ref-type="bibr" rid="ref54">54</xref>], 2021</td>
                <td>Observational (secondary data analysis)</td>
                <td>Low and middle educated</td>
                <td>App</td>
              </tr>
              <tr valign="top">
                <td>Cavallo [<xref ref-type="bibr" rid="ref45">45</xref>], 2016</td>
                <td>Observational</td>
                <td>Low income</td>
                <td>Web-based and social media</td>
              </tr>
              <tr valign="top">
                <td>Tagai [<xref ref-type="bibr" rid="ref50">50</xref>], 2020</td>
                <td>Observational</td>
                <td>Low income</td>
                <td>SMS text messaging</td>
              </tr>
              <tr valign="top">
                <td>Golsteijn [<xref ref-type="bibr" rid="ref36">36</xref>], 2017</td>
                <td>RCT</td>
                <td>Low, middle, and high education</td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Griffin [<xref ref-type="bibr" rid="ref43">43</xref>], 2018</td>
                <td>Observational</td>
                <td>Low income</td>
                <td>SMS text messaging</td>
              </tr>
              <tr valign="top">
                <td>Kim [<xref ref-type="bibr" rid="ref86">86</xref>], 2018</td>
                <td>Nonrandomized design</td>
                <td>Low income<sup>a</sup></td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Kothari [<xref ref-type="bibr" rid="ref68">68</xref>], 2020</td>
                <td>Design</td>
                <td>Low income<sup>a</sup></td>
                <td>App</td>
              </tr>
              <tr valign="top">
                <td>Leak [<xref ref-type="bibr" rid="ref63">63</xref>], 2014</td>
                <td>Design</td>
                <td>Low income<sup>a</sup></td>
                <td>Social media</td>
              </tr>
              <tr valign="top">
                <td>Kendzor [<xref ref-type="bibr" rid="ref51">51</xref>], 2020</td>
                <td>Observational</td>
                <td>Low income</td>
                <td>App</td>
              </tr>
              <tr valign="top">
                <td>van Dongen [<xref ref-type="bibr" rid="ref44">44</xref>], 2012</td>
                <td>Observational</td>
                <td>Low, middle, and high education</td>
                <td>Web-based (email)</td>
              </tr>
              <tr valign="top">
                <td>Lohse [<xref ref-type="bibr" rid="ref52">52</xref>], 2013</td>
                <td>Observational</td>
                <td>Low income</td>
                <td>Social media</td>
              </tr>
              <tr valign="top">
                <td>Mayberry [<xref ref-type="bibr" rid="ref74">74</xref>], 2016</td>
                <td>Design</td>
                <td>Low income</td>
                <td>SMS text messaging</td>
              </tr>
              <tr valign="top">
                <td>Michie [<xref ref-type="bibr" rid="ref55">55</xref>], 2012</td>
                <td>Design and observational</td>
                <td>Low SES</td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Neuenschwander [<xref ref-type="bibr" rid="ref79">79</xref>], 2013</td>
                <td>Block equivalence randomized trial</td>
                <td>Low income</td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Pathak [<xref ref-type="bibr" rid="ref75">75</xref>], 2021</td>
                <td>Design</td>
                <td>Low income<sup>a</sup></td>
                <td>App (and SMS text messaging)</td>
              </tr>
              <tr valign="top">
                <td>Patten [<xref ref-type="bibr" rid="ref87">87</xref>], 2019</td>
                <td>Nonrandomized design</td>
                <td>Low income</td>
                <td>SMS text messaging</td>
              </tr>
              <tr valign="top">
                <td>Radhakrishnan [<xref ref-type="bibr" rid="ref53">53</xref>], 2016</td>
                <td>Design and observational</td>
                <td>Low, middle, and high education</td>
                <td>App (mobile device video game)</td>
              </tr>
              <tr valign="top">
                <td>Herring [<xref ref-type="bibr" rid="ref35">35</xref>], 2014</td>
                <td>RCT</td>
                <td>Low income<sup>a</sup></td>
                <td>Web-based (social media) and mobile phone (text messaging)</td>
              </tr>
              <tr valign="top">
                <td>Régnier [<xref ref-type="bibr" rid="ref60">60</xref>], 2018</td>
                <td>Design</td>
                <td>Low SES neighborhoods</td>
                <td>App</td>
              </tr>
              <tr valign="top">
                <td>Ramirez [<xref ref-type="bibr" rid="ref34">34</xref>], 2017</td>
                <td>Pilot RCT</td>
                <td>Low income<sup>a</sup></td>
                <td>Text messaging or voice</td>
              </tr>
              <tr valign="top">
                <td>Silfee [<xref ref-type="bibr" rid="ref56">56</xref>], 2018</td>
                <td>Design and observational</td>
                <td>Low income</td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Silfee [<xref ref-type="bibr" rid="ref42">42</xref>], 2019</td>
                <td>Observational</td>
                <td>Low income<sup>a</sup> </td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Silk [<xref ref-type="bibr" rid="ref41">41</xref>], 2008</td>
                <td>Observational</td>
                <td>Low income</td>
                <td>Web-based vs games</td>
              </tr>
              <tr valign="top">
                <td>Simons [<xref ref-type="bibr" rid="ref58">58</xref>], 2018</td>
                <td>Design</td>
                <td>Lower education</td>
                <td>App</td>
              </tr>
              <tr valign="top">
                <td>Simons [<xref ref-type="bibr" rid="ref40">40</xref>], 2018</td>
                <td>RCT</td>
                <td>Lower education</td>
                <td>App</td>
              </tr>
              <tr valign="top">
                <td>Spears [<xref ref-type="bibr" rid="ref59">59</xref>], 2019</td>
                <td>Design</td>
                <td>Low SES</td>
                <td>SMS text messaging</td>
              </tr>
              <tr valign="top">
                <td>Schneider [<xref ref-type="bibr" rid="ref33">33</xref>], 2012</td>
                <td>RCT</td>
                <td>Low, middle, and high education</td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Stanczyk [<xref ref-type="bibr" rid="ref82">82</xref>], 2014</td>
                <td>Data from RCT</td>
                <td>Low, middle, and high education</td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Springvloet [<xref ref-type="bibr" rid="ref32">32</xref>], 2015</td>
                <td>RCT</td>
                <td>Low, middle, and high education</td>
                <td>Web-based</td>
              </tr>
              <tr valign="top">
                <td>Stotz [<xref ref-type="bibr" rid="ref76">76</xref>], 2018</td>
                <td>Design</td>
                <td>Low income</td>
                <td>Web-based on smartphone</td>
              </tr>
              <tr valign="top">
                <td>Tabak [<xref ref-type="bibr" rid="ref77">77</xref>], 2018</td>
                <td>Design</td>
                <td>Low income<sup>a</sup></td>
                <td>SMS text messaging</td>
              </tr>
              <tr valign="top">
                <td>Lohse [<xref ref-type="bibr" rid="ref57">57</xref>], 2013</td>
                <td>Design</td>
                <td>Low income<sup>a</sup></td>
                <td>Social media</td>
              </tr>
              <tr valign="top">
                <td>Wayne [<xref ref-type="bibr" rid="ref30">30</xref>], 2015</td>
                <td>RCT</td>
                <td>Low SES</td>
                <td>App</td>
              </tr>
              <tr valign="top">
                <td>Wayne [<xref ref-type="bibr" rid="ref78">78</xref>], 2014</td>
                <td>Single arm</td>
                <td>Low SES</td>
                <td>App</td>
              </tr>
              <tr valign="top">
                <td>Whittemore [<xref ref-type="bibr" rid="ref70">70</xref>], 2020</td>
                <td>Design</td>
                <td>Low income</td>
                <td>SMS text and MMS messaging</td>
              </tr>
              <tr valign="top">
                <td>Yee [<xref ref-type="bibr" rid="ref69">69</xref>], 2020</td>
                <td>Design</td>
                <td>Low income<sup>a</sup></td>
                <td>SMS text messaging</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>Socioeconomic status was not specified in the study.</p>
            </fn>
            <fn id="table1fn2">
              <p><sup>b</sup>RCT: randomized controlled trial.</p>
            </fn>
            <fn id="table1fn3">
              <p><sup>c</sup>SES: socioeconomic status.</p>
            </fn>
            <fn id="table1fn4">
              <p><sup>d</sup>Low education, unemployment, or living in poverty.</p>
            </fn>
            <fn id="table1fn5">
              <p><sup>e</sup>Socioeconomic status was determined by the occupation and employment status of the household’s primary income earner.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Intervention Development and Evaluation</title>
        <p>In the various stages of the development and evaluation of the intervention (ie, problem definition, development, and implementation for the study) [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref84">84</xref>], several studies involved stakeholders, which included family members, experts, key informants [<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref84">84</xref>,<xref ref-type="bibr" rid="ref86">86</xref>], health professionals, and end users [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref64">64</xref>-<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>-<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref83">83</xref>]. However, some studies provided little information on the identification of stakeholders and did not clarify the level of involvement of stakeholders and end users [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]. The studies used multiple methods, such as interviews, focus groups, and user testing [<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref64">64</xref>-<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref83">83</xref>], to gain insights from end users and stakeholders. Researchers used focus groups to map the needs and problems of the (potential) users [<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref73">73</xref>] and to gain input from stakeholders to adapt existing interventions [<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]. These methods also helped the researchers to gain insight into the challenges that participants experienced while using the intervention [<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref86">86</xref>] and their thoughts on the requirements of successful participation [<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]. Furthermore, other methods used the Community Engagement Studio [<xref ref-type="bibr" rid="ref74">74</xref>], a consumer panel [<xref ref-type="bibr" rid="ref32">32</xref>], and a collective discussion group [<xref ref-type="bibr" rid="ref60">60</xref>]. The researchers used these methods to improve the accessibility of the interventions for the end users [<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref74">74</xref>]. For the development phase, facilitators and barriers were related to technology and content factors. However, regarding the evaluation of the interventions, limited facilitators and barriers were mentioned. Several studies adapted existing interventions, which were developed and tested in different SES groups with various health concerns, such as diabetes, hypertension, mental disorders, and pregnancy [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref85">85</xref>-<xref ref-type="bibr" rid="ref87">87</xref>].</p>
        <p>Studies adapted these interventions and the delivery modality for use in different low SES groups. Nevertheless, many studies retained most of the content and components of the existing interventions [<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]. Many studies chose to adapt the content of the intervention and apply linguistic and content simplification, such as using plain language and low content load through the use of images and videos [<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref86">86</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]. Some studies also made cultural adaptations by using updated cultural components [<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref86">86</xref>], translating the content into a second language (eg, Spanish), and employing bilingual coaches [<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]. Although intervention adaptation was common, documentation of the adjustment process was scarce. Only 3 studies [<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref85">85</xref>] described in detail the adaptation process and what changes they performed. Furthermore, 2 studies used frameworks (Stirman and the intervention mapping protocol) [<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref85">85</xref>], and 1 study [<xref ref-type="bibr" rid="ref87">87</xref>] used a model (Stage Model) to adapt the intervention.</p>
      </sec>
      <sec>
        <title>Tailoring</title>
        <p>The majority of the studies tailored the eHealth interventions in various ways to the characteristics and skills of people with a low SES [<xref ref-type="bibr" rid="ref23">23</xref>, <xref ref-type="bibr" rid="ref31">31</xref>-<xref ref-type="bibr" rid="ref37">37</xref>, <xref ref-type="bibr" rid="ref40">40</xref>, <xref ref-type="bibr" rid="ref45">45</xref>, <xref ref-type="bibr" rid="ref46">46</xref>, <xref ref-type="bibr" rid="ref50">50</xref>, <xref ref-type="bibr" rid="ref58">58</xref>, <xref ref-type="bibr" rid="ref61">61</xref>, <xref ref-type="bibr" rid="ref62">62</xref>, <xref ref-type="bibr" rid="ref64">64</xref>, <xref ref-type="bibr" rid="ref66">66</xref>, <xref ref-type="bibr" rid="ref69">69</xref>-<xref ref-type="bibr" rid="ref72">72</xref>, <xref ref-type="bibr" rid="ref74">74</xref>-<xref ref-type="bibr" rid="ref77">77</xref>, <xref ref-type="bibr" rid="ref81">81</xref>-<xref ref-type="bibr" rid="ref86">86</xref>, <xref ref-type="bibr" rid="ref88">88</xref>]. One method of customizing the eHealth intervention matched the content delivery (eg, visual or text information) to the user’s language and digital literacy skills [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref84">84</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]. Another method tailored feedback, advice, and information to the characteristics (eg, cultural adaptations and practical advice relevant to their situation) of individuals with a low SES [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>-<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref81">81</xref>-<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref85">85</xref>] or the timing and type of text messages (eg, feedback) [<xref ref-type="bibr" rid="ref83">83</xref>]. However, it is unknown how tailoring was applied (technology or human tailoring, or a combination of both methods). A few studies based tailoring on theoretical models of behavioral change [<xref ref-type="bibr" rid="ref31">31</xref>-<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref70">70</xref>] and gathered information through questionnaires [<xref ref-type="bibr" rid="ref31">31</xref>-<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref85">85</xref>], self-monitoring data [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref83">83</xref>], or intervention goals [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref74">74</xref>]. However, tailoring the intervention system to deliver feedback or advice proved challenging as it required technological expertise and financial recourses [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref40">40</xref>]. It is unclear whether tailoring led to better results. Because of tailoring the feedback, 1 study showed that lower-educated smokers were more likely to revisit the intervention website [<xref ref-type="bibr" rid="ref82">82</xref>].</p>
      </sec>
      <sec>
        <title>Reach</title>
        <p>The included studies applied multiple strategies to recruit low SES participants. However, some studies (n=5; 8%) provided limited details on the strategies they used to reach their participants [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref79">79</xref>]. The recruitment strategies and places are summarized in <xref ref-type="table" rid="table2">Table 2</xref>.</p>
        <p>Different methods were found to be helpful to reach low SES participants. Lohse et al [<xref ref-type="bibr" rid="ref52">52</xref>] found that Facebook is an effective tool to reach low-income women. Furthermore, the studies that used a personal approach to recruit participants reported a higher enrollment rate [<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref82">82</xref>,<xref ref-type="bibr" rid="ref86">86</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]. For example, Patten et al [<xref ref-type="bibr" rid="ref87">87</xref>] found that reaching the targeted population with a face-to-face outreach method was more successful compared to recruitment through flyers. Kim et al [<xref ref-type="bibr" rid="ref86">86</xref>] found that personal or telephone approaches to recruiting participants were responsible for most of the enrollments in their study. Moreover, participants indicated that they were more receptive to participating in a study when their doctor had previously discussed it with them [<xref ref-type="bibr" rid="ref86">86</xref>]. Another study found that smokers recruited through general practitioners were more likely to be lower educated and already living with smoking-related illnesses than participants recruited through the internet [<xref ref-type="bibr" rid="ref82">82</xref>].</p>
        <p>Some studies experienced challenges in reaching low SES groups. These studies reached mainly medium or highly educated [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref44">44</xref>] participants with stable incomes and relatively healthy lifestyles [<xref ref-type="bibr" rid="ref33">33</xref>]. van Dongen et al [<xref ref-type="bibr" rid="ref44">44</xref>] indicated that people with a low SES may be reached with the right strategies, such as integrating an eHealth intervention into standard midwifery care, increasing awareness about the intervention’s existence by expanding mass media use, and involving key community representatives of the target group. Additionally, some studies recommended increasing the reach of lifestyle interventions by collaborating with other experts, such as designers and health professionals [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]. <xref ref-type="table" rid="table3">Tables 3</xref> and <xref ref-type="table" rid="table4">4</xref> show the barriers and facilitators for reach found in the studies.</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Participant recruitment, places, and strategies.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="820"/>
            <col width="0"/>
            <col width="150"/>
            <col width="0"/>
            <thead>
              <tr valign="top">
                <td colspan="3">Recruitment characteristic</td>
                <td colspan="2">Number of studies</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="3">
                  <bold>Individuals involved in recruitment</bold>
                </td>
                <td colspan="2">
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Health professionals [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref81">81</xref>-<xref ref-type="bibr" rid="ref85">85</xref>]<sup>.</sup></td>
                <td colspan="2">11</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Researchers [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref81">81</xref>] and research assistants [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref80">80</xref>]</td>
                <td colspan="2">8</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Study coordinators [<xref ref-type="bibr" rid="ref86">86</xref>], managers [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>], organization staff [<xref ref-type="bibr" rid="ref68">68</xref>], and agent assistance [<xref ref-type="bibr" rid="ref48">48</xref>]</td>
                <td colspan="2">5</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Paraprofessionals [<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref79">79</xref>] and volunteers [<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]</td>
                <td colspan="2">4</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Snowballing (<italic>participants recruited other participants</italic>) [<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref82">82</xref>]</td>
                <td colspan="2">4</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td colspan="3">
                  <bold>Recruitment places</bold>
                </td>
                <td colspan="2">
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td> Health care setting [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref83">83</xref>-<xref ref-type="bibr" rid="ref86">86</xref>]</td>
                <td colspan="2">19</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Federal Benefit and Assistance Program for low-income women [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref73">73</xref>] and families [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref79">79</xref>]</td>
                <td colspan="2">12</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Workplaces [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref77">77</xref>] and care services [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref60">60</xref>]</td>
                <td colspan="2">4</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Local communities [<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]</td>
                <td colspan="2">5</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Food bank distributors [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]</td>
                <td colspan="2">3</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Public health insurance [<xref ref-type="bibr" rid="ref70">70</xref>]</td>
                <td colspan="2">1</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Local nongovernmental organizations [<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref60">60</xref>]</td>
                <td colspan="2">2</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Public places [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]</td>
                <td colspan="2">2</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Research agencies [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref71">71</xref>]</td>
                <td colspan="2">2</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td colspan="3">
                  <bold>Recruitment strategies</bold>
                </td>
                <td colspan="2">
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Online [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref76">76</xref>-<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref82">82</xref>,<xref ref-type="bibr" rid="ref84">84</xref>-<xref ref-type="bibr" rid="ref87">87</xref>]</td>
                <td colspan="2">27</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Newspaper advertisements [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref85">85</xref>], banners [<xref ref-type="bibr" rid="ref44">44</xref>], flyers, and posters [<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]</td>
                <td colspan="2">16</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Personal contact (face-to-face) [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref83">83</xref>] or via phone [<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]</td>
                <td colspan="2">12</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Postal invitation letters [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref57">57</xref>]</td>
                <td colspan="2">3</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Local television campaigns [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref82">82</xref>]</td>
                <td colspan="2">2</td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Regional health authority [<xref ref-type="bibr" rid="ref33">33</xref>]</td>
                <td colspan="2">1</td>
                <td>
                  <break/>
                </td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Overview of facilitators identified in the eHealth interventions.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="670"/>
            <col width="0"/>
            <col width="300"/>
            <thead>
              <tr valign="top">
                <td colspan="3">Facilitators per phase</td>
                <td>Studies</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="3">
                  <bold>Development</bold>
                </td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Iterative design of the intervention (user-centered approach)</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref74">74</xref>-<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref85">85</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Study staff collaborating with other experts or a digital health company</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref88">88</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Broad number of data sources to inform development</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref75">75</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Participants’ knowledge of technology</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Providing devices</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref51">51</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Concise and clear content</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>-<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref75">75</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Use of visual and multimedia elements</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref63">63</xref>-<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref73">73</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Resonating content of the intervention with participants</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref85">85</xref>]</td>
              </tr>
              <tr valign="top">
                <td colspan="3">
                  <bold>Evaluation</bold>
                </td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Conducting formative evaluation in the early stage of the intervention</td>
                <td colspan="2"> [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref74">74</xref>-<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref85">85</xref>]</td>
              </tr>
              <tr valign="top">
                <td colspan="3">
                  <bold>Reach</bold>
                </td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Recruitment through Facebook, and active recruitment through health care professionals and tailored recruitment strategies</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref82">82</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Collaborating with other experts, such as designers and health professionals, and local community services</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref76">76</xref>]</td>
              </tr>
              <tr valign="top">
                <td colspan="3">
                  <bold>Use</bold>
                </td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Social support (friends, family, and peers)</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref74">74</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Self-monitoring</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Human coach can be helpful for participants</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Practical advice to incorporate a healthy lifestyle in daily life</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref73">73</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Reminders</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Trust (eg, have a familiar face posting on a social media page) and credible information</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Recipes and meal ideas may be useful</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref73">73</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Helping participants with technology use</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>User friendliness and simplicity</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref73">73</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Interactive features</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref64">64</xref>-<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Providing incentives and rewards (eg, virtual or financial rewards)</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Links to more information</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Combining social media with face-to-face group sessions</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Networking with others encourages participants’ use of social media interventions</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref63">63</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Activities must focus on pleasure and not obligation</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Incorporating affordable options</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref61">61</xref>]</td>
              </tr>
              <tr valign="top">
                <td colspan="3">
                  <bold>Implementation</bold>
                </td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Supplying the intervention through different platforms</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref36">36</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Increasing direct communication with the health coach</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref61">61</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Training health care professionals</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref70">70</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Collaborating with health insurance</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref70">70</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Server support staff and marketing team continually monitoring the intervention for technical issues</td>
                <td colspan="2"> [<xref ref-type="bibr" rid="ref76">76</xref>]</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <table-wrap position="float" id="table4">
          <label>Table 4</label>
          <caption>
            <p>Overview of barriers identified in the eHealth interventions.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="600"/>
            <col width="0"/>
            <col width="370"/>
            <thead>
              <tr valign="top">
                <td colspan="3">Barriers per phase</td>
                <td>Studies</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="3">
                  <bold>Development</bold>
                </td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Technical challenges with the intervention software or prototype</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Amount of information or visuals</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref85">85</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td> Limited financial resources for the intervention</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref72">72</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Optimal frequency for reminders or messages</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]</td>
              </tr>
              <tr valign="top">
                <td colspan="3">
                  <bold>Evaluation</bold>
                </td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Evaluation is time-consuming</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref62">62</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Slow iterations of the intervention in the academic field</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref65">65</xref>]</td>
              </tr>
              <tr valign="top">
                <td colspan="3">
                  <bold>Reach</bold>
                </td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Introductory study presentations and sending reminders to clinicians had a limited effect on increasing referrals</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref86">86</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Passive recruitment (flyers)</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref87">87</xref>]</td>
              </tr>
              <tr valign="top">
                <td colspan="3">
                  <bold>Use</bold>
                </td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Technical difficulties using a self-monitoring device or eHealth intervention (eg, lack of internet access, problems with telephones, and poor signal)</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref49">49</xref>-<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref85">85</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Limited digital skills of users and lack of knowledge of innovative technologies</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Not wanting extra push notifications and lost notifications among all the notifications from other apps</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Not allowed to carry a smartphone during work or does not carry a phone</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref75">75</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Literacy and not mastering the language</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref70">70</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Lack of time in a low SES<sup>a</sup> group</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref78">78</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Financial problems (eg, paying bills)</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Lack of familiarity with other participants before using social media and trust in social media or the internet</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref60">60</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Waning participant interest toward the end of the intervention period and low motivation</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref61">61</xref>]</td>
              </tr>
              <tr valign="top">
                <td colspan="3">
                  <bold>Implementation</bold>
                </td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Limited time of staff or coaches</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref74">74</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Limited financial resources</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref72">72</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Difficulties getting medical data of participants from participating health care facilities</td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref86">86</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Limited ability of peer coaches</td>
                <td colspan="2"> [<xref ref-type="bibr" rid="ref72">72</xref>]</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table4fn1">
              <p><sup>a</sup>SES: socioeconomic status.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Use of eHealth Interventions</title>
        <p>Most studies did not mention how the participants used the eHealth lifestyle interventions. However, many studies gained insight into the intervention usage by evaluating the concepts of adherence, user engagement, and acceptance [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref81">81</xref>]. Most of the studies showed that participants with a low SES accepted the eHealth interventions [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref80">80</xref>]. When there was high adherence, usage, and user engagement, interventions seemed effective [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref81">81</xref>].</p>
        <p>Several studies mentioned explicitly measuring intervention usage with Google Analytics (eg, user interactions with content) [<xref ref-type="bibr" rid="ref40">40</xref>], log data [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref61">61</xref>], registration data [<xref ref-type="bibr" rid="ref44">44</xref>], emails sent, quiz questions accessed [<xref ref-type="bibr" rid="ref44">44</xref>], questionnaires [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref64">64</xref>], or self-monitoring questionnaires [<xref ref-type="bibr" rid="ref39">39</xref>]. The data analysis demonstrated that interventions were used as intended [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref81">81</xref>]. However, Régnier et al [<xref ref-type="bibr" rid="ref60">60</xref>] found that the intervention was used to a less extent due to different barriers, such as technical issues, lack of language skills, and searching for real contact. In addition, Simons et al [<xref ref-type="bibr" rid="ref40">40</xref>] reported decreased use during the intervention because of lesser engagement with the intervention. It also emerged that there was a difference between users within the interventions [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref81">81</xref>]. For example, in a study, it was found that the users who received notifications with tips, facts, and feedback mostly used the intervention [<xref ref-type="bibr" rid="ref40">40</xref>]. Using periodic email prompts significantly increased the reuse of the intervention [<xref ref-type="bibr" rid="ref33">33</xref>]. Schneider et al [<xref ref-type="bibr" rid="ref33">33</xref>] concluded that it is crucial to develop strategies that encourage engagement from people with a low SES. Furthermore, hedonic elements (eg, visual elements) in the intervention were significantly associated with increased use [<xref ref-type="bibr" rid="ref54">54</xref>]. In another study, personal and nuisance factors were associated with lower intervention use, including lower educational achievement and perceived barriers (eg, no time or interest and technical problems) [<xref ref-type="bibr" rid="ref49">49</xref>]. Barriers and facilitators for using the interventions were diverse and varied in terms of individual and technological factors (<xref ref-type="table" rid="table3">Tables 3</xref> and <xref ref-type="table" rid="table4">4</xref>).</p>
        <p>Other studies have analyzed adherence to interventions [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref87">87</xref>] by measuring the numbers of messages sent by participants, completion of coach calls [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref87">87</xref>], or intention to visit or revisit the intervention, or using specific features of the intervention, self-monitoring data, and days that participants used the intervention [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref49">49</xref>]. Adherence to the intervention decreased gradually in certain studies [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref49">49</xref>]. Griffin et al [<xref ref-type="bibr" rid="ref48">48</xref>] showed that noncompleters of the intervention had certain characteristics (were younger, were African American, had a high BMI, had a lower education [high school or lower], and had a low income) when compared with participants who completed the intervention. Engagement with interventions was measured through the self-management behavior of participants [<xref ref-type="bibr" rid="ref86">86</xref>], the tracking of their behavior via self-monitoring devices [<xref ref-type="bibr" rid="ref86">86</xref>], self-reporting [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref64">64</xref>], and the presence of several likes, comments, and posts or messages assessed throughout the intervention delivery [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref86">86</xref>], as well as by capturing the frequency of user logins [<xref ref-type="bibr" rid="ref86">86</xref>]. At the time when intervention engagement was high in several studies [<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref72">72</xref>], in other studies, engagement decreased during the use of the intervention [<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref71">71</xref>]. In 1 study, participants were more engaged with text messages than voice messages [<xref ref-type="bibr" rid="ref34">34</xref>]. Another study showed that participant contributions appeared to vary across time of the day and day of the week (more active in the beginning part of the week and during the middle of the day) [<xref ref-type="bibr" rid="ref47">47</xref>].</p>
      </sec>
      <sec>
        <title>Delivery Mode of the Intervention</title>
        <p>There was a wide variation in the delivery mode of the intervention. <xref ref-type="table" rid="table1">Table 1</xref> provides an overview of the modes used to deliver the intervention. The studies cited several reasons for using a certain delivery mode. Using the internet [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref86">86</xref>], smartphone apps [<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref78">78</xref>], or text messages [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref75">75</xref>] offers many benefits. Internet-based [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref86">86</xref>] and text-based [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref87">87</xref>] interventions are good channels for reaching hard-to-reach groups and might be effective in changing healthy behavior [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref70">70</xref>]. They also help to investigate new channels or to deliver interventions to low SES individuals [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref79">79</xref>]. Finally, low SES individuals use the internet, which provides the interventions an opportunity to reach this target group [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref56">56</xref>-<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref86">86</xref>].</p>
        <p>Studies reporting on the effectiveness of the delivery mode demonstrated no unequivocal results. Three studies showed that a web-based intervention was more effective for low SES participants [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref79">79</xref>] than non-eHealth interventions, such as in-person counselling for low SES participants [<xref ref-type="bibr" rid="ref79">79</xref>] and game-based versions [<xref ref-type="bibr" rid="ref41">41</xref>], and website users had deeper knowledge and a higher intention to use the website henceforth [<xref ref-type="bibr" rid="ref41">41</xref>]. Another study [<xref ref-type="bibr" rid="ref53">53</xref>] demonstrated that a gamified intervention significantly improved heart failure self-management knowledge in low SES and high SES participants. Participants with lower education levels and older adults preferred a digital game to any other medium for receiving information on self-management of heart failure. One RCT reported no interaction effects between delivery strategy (video versus text advice) and education level in terms of message processing mechanisms and future use of a smoking cessation intervention [<xref ref-type="bibr" rid="ref82">82</xref>].</p>
      </sec>
      <sec>
        <title>Implementation</title>
        <p>Most studies did not adequately describe how their respective eHealth lifestyle interventions were implemented, perhaps because almost all the interventions were pilot projects and were not implemented in practice after the study was completed. The few barriers and facilitators that were identified are listed in <xref ref-type="table" rid="table3">Tables 3</xref> and <xref ref-type="table" rid="table4">4</xref>.</p>
        <p>Several studies reported that they collaborated with different disciplines for implementation [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref85">85</xref>]. Golsteijn et al [<xref ref-type="bibr" rid="ref85">85</xref>] created a network of hospitals and radiotherapy institutes to implement the intervention. However, their results on implementation are unknown. Furthermore, it appears that health professionals play an important role in the implementation of interventions [<xref ref-type="bibr" rid="ref70">70</xref>].</p>
        <p>Very few studies discussed the cost of their eHealth interventions. Limited finances and staff time presented several challenges in implementing these interventions [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref72">72</xref>]. Tabak et al [<xref ref-type="bibr" rid="ref77">77</xref>] considered practicality and sustainability of the intervention by choosing interventions that prevented higher cost, for example, providing automatic feedback instead of individualized feedback. Other examples include finding enough coaches with the expertise to guide participants [<xref ref-type="bibr" rid="ref72">72</xref>] and working with their time constraints [<xref ref-type="bibr" rid="ref74">74</xref>]. Studies that reported on how they evaluated the implementation of their interventions were scarce. However, 1 study [<xref ref-type="bibr" rid="ref85">85</xref>] used intervention mapping to develop an implementation plan. Two studies plan to evaluate implementation in the future. Whittemore et al [<xref ref-type="bibr" rid="ref70">70</xref>] aimed to document an implementation analysis, and Foley et al [<xref ref-type="bibr" rid="ref37">37</xref>] aimed to evaluate implementation through the RE-AIM framework.</p>
      </sec>
      <sec>
        <title>Effectiveness</title>
        <p>A number of studies (n=19) [<xref ref-type="bibr" rid="ref23">23</xref>, <xref ref-type="bibr" rid="ref30">30</xref>, <xref ref-type="bibr" rid="ref32">32</xref>, <xref ref-type="bibr" rid="ref33">33</xref>, <xref ref-type="bibr" rid="ref34">34</xref>, <xref ref-type="bibr" rid="ref35">35</xref>, <xref ref-type="bibr" rid="ref36">36</xref>, <xref ref-type="bibr" rid="ref38">38</xref>, <xref ref-type="bibr" rid="ref39">39</xref>, <xref ref-type="bibr" rid="ref41">41</xref>, <xref ref-type="bibr" rid="ref43">43</xref>, <xref ref-type="bibr" rid="ref45">45</xref>, <xref ref-type="bibr" rid="ref46">46</xref>, <xref ref-type="bibr" rid="ref48">48</xref>, <xref ref-type="bibr" rid="ref50">50</xref>, <xref ref-type="bibr" rid="ref79">79</xref>-<xref ref-type="bibr" rid="ref82">82</xref>] investigated the effectiveness of interventions for smoking cessation [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref81">81</xref>], healthy eating behaviors [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref79">79</xref>], alcohol [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref80">80</xref>], weight loss [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>], physical activity [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref40">40</xref>], and multiple lifestyle changes [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref78">78</xref>]. Three studies [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref81">81</xref>] were effective in achieving smoking cessation in the low SES group. Furthermore, some studies reported significant improvements in eating behaviors [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref79">79</xref>], reduction in weight [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref48">48</xref>], and increase in physical activity [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref48">48</xref>]. Two RCTs showed that interventions were more effective in high SES participants than in low SES participants [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref36">36</xref>]. One study [<xref ref-type="bibr" rid="ref32">32</xref>] found educational differences in high-energy snack intake. In this previous study, the plus group (environmental-level factors) received information on the availability and location of healthy food in the home environment and the prices of healthy food products in the supermarkets that the participants usually shop at. The plus approach targeted higher-educated participants more effectively than the basic approach, which was more effective for lower-educated participants. The authors argued that higher-educated participants understood and applied the environmental-level information easier than the lower-educated participants. The intervention as described by Golsteijn et al [<xref ref-type="bibr" rid="ref36">36</xref>] resulted in a significant improvement in self-reported physical activity. However, the highly educated group initially participated more on the web than their lower-educated peers. In contrast to a study, they found minor effects in low SES participants, but no effect in participants with a higher SES [<xref ref-type="bibr" rid="ref23">23</xref>]. The authors stated that this is likely because the user testing of the intervention was conducted exclusively with smokers with a low SES, which contributed to its effectiveness in the low SES group.</p>
        <p>Two studies [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref45">45</xref>] reported minor significant improvements and modest effects on reuse of a healthy lifestyle program [<xref ref-type="bibr" rid="ref33">33</xref>]. Other studies reported an insignificant effect [<xref ref-type="bibr" rid="ref40">40</xref>] due to lower user engagement and dropouts.</p>
      </sec>
      <sec>
        <title>Intervention Components</title>
        <p>Studies applied diverse components within the interventions. For example, they employed visual and multimedia elements, such as images, infographics, videos, and social support. To a lesser extent, there was human or virtual coaching, and incentives were used. <xref ref-type="table" rid="table5">Table 5</xref> presents an overview of the components in eHealth lifestyle interventions.</p>
        <table-wrap position="float" id="table5">
          <label>Table 5</label>
          <caption>
            <p>Overview of the eHealth lifestyle intervention components (N=59).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="800"/>
            <col width="200"/>
            <thead>
              <tr valign="top">
                <td>Components</td>
                <td>Studies, n (%)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td> Multimedia (images, infographs, and videos) [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref55">55</xref>-<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref59">59</xref>-<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref84">84</xref>-<xref ref-type="bibr" rid="ref86">86</xref>]</td>
                <td>30 (51)</td>
              </tr>
              <tr valign="top">
                <td> Self-monitoring [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref34">34</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>-<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref76">76</xref>-<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref84">84</xref>,<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]</td>
                <td> 28 (47)</td>
              </tr>
              <tr valign="top">
                <td> Tips [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref38">38</xref>-<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>-<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref75">75</xref>-<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref84">84</xref>-<xref ref-type="bibr" rid="ref88">88</xref>]</td>
                <td>28 (47)</td>
              </tr>
              <tr valign="top">
                <td>Social support [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref71">71</xref>-<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref84">84</xref>-<xref ref-type="bibr" rid="ref87">87</xref>]</td>
                <td>25 (42)</td>
              </tr>
              <tr valign="top">
                <td> Reminders [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref84">84</xref>-<xref ref-type="bibr" rid="ref86">86</xref>]</td>
                <td>23 (39)</td>
              </tr>
              <tr valign="top">
                <td> Rewards/incentives [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref45">45</xref>-<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]</td>
                <td>22 (37)</td>
              </tr>
              <tr valign="top">
                <td> Coach [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref84">84</xref>-<xref ref-type="bibr" rid="ref87">87</xref>]</td>
                <td>18 (31)</td>
              </tr>
              <tr valign="top">
                <td> Theoretical frameworks [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref31">31</xref>-<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref73">73</xref>-<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref85">85</xref>]</td>
                <td> 23 (39)</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <sec>
          <title>Theoretical Frameworks</title>
          <p>Several studies (n=23, 39%) stated that they used one or more theoretical frameworks in their interventions [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref31">31</xref>-<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref73">73</xref>-<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref85">85</xref>]. The frameworks most commonly used were the social cognitive theory [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref85">85</xref>], I-Change Model [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref85">85</xref>], and theory of planned behavior [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref85">85</xref>], followed by the Health Belief Model [<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref85">85</xref>], theories of self-regulation [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref85">85</xref>], and Precaution Adoption Process Model [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref85">85</xref>]. However, several studies mentioned using the Techniques of Behavior Change [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref77">77</xref>]; the theories for the rest of the studies can be found in <xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref>. Few studies used the frameworks to develop, adapt, evaluate, or implement the eHealth interventions [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref79">79</xref>]. It is unclear whether these theories were associated with desirable effects. Although not all studies have reported why they chose the theories [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref82">82</xref>], a few mentioned using the constructs or determinants of the theories [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref85">85</xref>], due to their suitability and available evidence [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref85">85</xref>]. Furthermore, it appeared that some interventions included components, such as self-monitoring, reminders, and social support based on behavioral strategies or theoretical frameworks, to promote lifestyle change or maintain healthy behaviors.</p>
        </sec>
        <sec>
          <title>Multimedia and Visual Elements</title>
          <p>Many studies included multimedia in their interventions, such as videos [<xref ref-type="bibr" rid="ref35">35</xref>, <xref ref-type="bibr" rid="ref36">36</xref>, <xref ref-type="bibr" rid="ref37">37</xref>, <xref ref-type="bibr" rid="ref61">61</xref>, <xref ref-type="bibr" rid="ref79">79</xref>, <xref ref-type="bibr" rid="ref85">85</xref>, <xref ref-type="bibr" rid="ref86">86</xref>] or images [<xref ref-type="bibr" rid="ref23">23</xref>, <xref ref-type="bibr" rid="ref38">38</xref>, <xref ref-type="bibr" rid="ref40">40</xref>, <xref ref-type="bibr" rid="ref46">46</xref>, <xref ref-type="bibr" rid="ref53">53</xref>, <xref ref-type="bibr" rid="ref55">55</xref>, <xref ref-type="bibr" rid="ref59">59</xref>, <xref ref-type="bibr" rid="ref62">62</xref>, <xref ref-type="bibr" rid="ref63">63</xref>, <xref ref-type="bibr" rid="ref89">89</xref>]. Although it was unclear why studies included these materials; some used videos [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref86">86</xref>] to introduce the intervention components [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref61">61</xref>], provide skills training [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref79">79</xref>], give home exercise instructions [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref85">85</xref>], or introduce the participants to their coach [<xref ref-type="bibr" rid="ref86">86</xref>]. Other studies used visual materials, such as images and videos, to increase engagement [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref76">76</xref>]. Interventions applied images because of their visual appeal and ease to recall [<xref ref-type="bibr" rid="ref55">55</xref>], or to enhance learning and motivate users to continue using the program [<xref ref-type="bibr" rid="ref76">76</xref>]. There was almost no mention of using graphic artists [<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref76">76</xref>] or photographers [<xref ref-type="bibr" rid="ref76">76</xref>] to create illustrations for the interventions. However, Evans et al [<xref ref-type="bibr" rid="ref62">62</xref>] stated that selecting illustrations for the app was challenging because matching the main text with illustrations was not always easy and required more iterations to meet the criteria. It was also challenging to find the right graphic artist to design proper images based on the given assignment. In 1 study [<xref ref-type="bibr" rid="ref56">56</xref>], long videos resulted in lower engagement with Facebook participants. Another qualitative study [<xref ref-type="bibr" rid="ref60">60</xref>] found that participants who experience language barriers rely more on visual materials (ie, videos) than written materials. However, a study reported that illustrations crowded with visual details confused participants [<xref ref-type="bibr" rid="ref62">62</xref>]. Another study [<xref ref-type="bibr" rid="ref63">63</xref>] highlighted that participants emphasized the importance of photos and visual appeal. In the study by Silfee et al [<xref ref-type="bibr" rid="ref56">56</xref>], participants were more likely to read and comment on Facebook posts containing messages with images. One study [<xref ref-type="bibr" rid="ref40">40</xref>] made it possible for the participants to see their daily steps via graphs. Although participants appreciated graphs, they used them significantly less at the end of the intervention due to decreased interest and outdated graph data. Only 1 study chose audio to increase the media on the website and facilitate relapse prevention and coping [<xref ref-type="bibr" rid="ref55">55</xref>].</p>
        </sec>
        <sec>
          <title>Social Support</title>
          <p>Participants’ peers [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref86">86</xref>] or significant others [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref87">87</xref>] provided social support, online or offline [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]. Other studies only gave advice on how people can get social support to help each other to adopt new behaviors [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref88">88</xref>]. Three studies mentioned that participants had positive experiences with the social support provided by their significant others [<xref ref-type="bibr" rid="ref34">34</xref>] or peers [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref71">71</xref>] (they perceived a sense of community and social [<xref ref-type="bibr" rid="ref71">71</xref>], emotional, and instrumental support [<xref ref-type="bibr" rid="ref34">34</xref>]) and that peers motivated them [<xref ref-type="bibr" rid="ref56">56</xref>]. For others, the ability to network and interact with peers was an important reason to visit the social media of the intervention [<xref ref-type="bibr" rid="ref63">63</xref>]. However, it is difficult to determine whether social support contributed to the increased effectiveness of some interventions.</p>
          <p>Several studies provided support through social media [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]. Participants were part of an online social network where they could, for example, discuss their goals [<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref86">86</xref>] and challenges [<xref ref-type="bibr" rid="ref86">86</xref>], and offer each other social support [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref61">61</xref>]. However, the studies identified different challenges in supporting active participation in the social support component, such as lack of a connection with other participants before accessing the eHealth intervention, limited engagement with other participants on social media [<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref61">61</xref>], and not receiving timely responses from other participants [<xref ref-type="bibr" rid="ref63">63</xref>]. Furthermore, in a qualitative study [<xref ref-type="bibr" rid="ref61">61</xref>], participants experienced their level of literacy as an obstacle to taking part in online discussions, while in another study, posting about themselves made some participants with low SES uncomfortable [<xref ref-type="bibr" rid="ref56">56</xref>], and others did not want to share their unsuccessful weight loss [<xref ref-type="bibr" rid="ref56">56</xref>]. Involving support persons in the intervention appears to be complicated; some participants with low SES had no support person or did not want to involve one [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref74">74</xref>]. Furthermore, Pathak et al [<xref ref-type="bibr" rid="ref75">75</xref>] showed that participants who had no family disliked messages that alluded to family support, and the term was replaced by loved ones (similar to familial relations). The interventions [<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref63">63</xref>] offered many solutions to encourage the use of social support on social media, such as team-building exercises and enlisting friends [<xref ref-type="bibr" rid="ref45">45</xref>]. The majority of participants of a smoking intervention relapsed, nonrelapsers reported significantly less temptation to smoke, and the qualitative data showed that nonrelapsers were able to manage temptation and reported greater support [<xref ref-type="bibr" rid="ref50">50</xref>].</p>
        </sec>
        <sec>
          <title>Self-monitoring</title>
          <p>Several studies used few self-monitoring devices, based on emerging evidence or previous studies [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref85">85</xref>], such as pedometers [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref86">86</xref>] and weight scales [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]. Participants with a low SES monitored their diets digitally [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref60">60</xref>], with a calorie-counting book [<xref ref-type="bibr" rid="ref45">45</xref>], or kept paper records [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]. Physical activity was also tracked through Fitbit devices [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref77">77</xref>] and MyFitnessPal [<xref ref-type="bibr" rid="ref56">56</xref>]. Participants entered self-monitoring data [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref43">43</xref>], or this was done automatically [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]. Simons et al [<xref ref-type="bibr" rid="ref40">40</xref>] found that continuous engagement with a self-monitoring device was challenging, due to participants not wearing the tracker or forgetting to charge it. Few studies provided information about the participants’ experiences, or why the studies chose self-monitoring devices. However, some studies mentioned that participants found self-monitoring devices easy [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref61">61</xref>] and comfortable to use [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]. In 2 studies, participants struggled to use tracking devices [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref56">56</xref>], while in another study, participants desired digital apps for calorie counting [<xref ref-type="bibr" rid="ref45">45</xref>]. It is difficult to determine whether self-monitoring led to increased effectiveness of the intervention. However, 1 study found that food photo journaling improved dietary choices more than having a health coach only [<xref ref-type="bibr" rid="ref30">30</xref>].</p>
        </sec>
        <sec>
          <title>Reminders</title>
          <p>Sending reminders to participants was used by many studies; however, it is unclear in some studies how they applied the reminders in their interventions [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref71">71</xref>]. Two studies applied reminders to improve the adoption of and adherence to healthy behaviors [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref78">78</xref>] and to improve heart failure self-management skills [<xref ref-type="bibr" rid="ref53">53</xref>]. Other studies applied reminders to encourage participants with low and high SES to visit or revisit the intervention [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref86">86</xref>], to remind users about their goals [<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref85">85</xref>], and to remind users to submit their self-monitoring information [<xref ref-type="bibr" rid="ref37">37</xref>]. Reminders were often used in the form of automatic emails [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref86">86</xref>,<xref ref-type="bibr" rid="ref89">89</xref>], push messages via smartphones [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref86">86</xref>], text messages via mobile phones [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref59">59</xref>], and news updates [<xref ref-type="bibr" rid="ref85">85</xref>]. The majority of studies did not report on how the participants evaluated the reminders. However, 2 studies showed that participants with a low SES found reminders helpful [<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]. Furthermore, 2 studies indicated that participants had a greater need for reminders [<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]. Some interventions that employed reminders appeared to be effective [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref33">33</xref>]. For example, in an RCT, reminders increased revisits to the intervention [<xref ref-type="bibr" rid="ref33">33</xref>].</p>
        </sec>
        <sec>
          <title>Coaches</title>
          <p>Several studies included a coaching component in the intervention [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref84">84</xref>-<xref ref-type="bibr" rid="ref87">87</xref>]. The coaches provided guidance mainly by telephone [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref84">84</xref>,<xref ref-type="bibr" rid="ref87">87</xref>], followed by face-to-face counselling [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref87">87</xref>], text messages, email [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref78">78</xref>], online counselling [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref86">86</xref>], or combinations of these methods [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref78">78</xref>]. This was done through health professionals [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref85">85</xref>], researchers [<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref87">87</xref>], parahealth professionals [<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref72">72</xref>], and automatic phone [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref72">72</xref>]. The roles of the coaches varied and included guiding participants in setting goals [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>], helping to solve problems [<xref ref-type="bibr" rid="ref85">85</xref>], and providing behavioral skills training [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref56">56</xref>], and they also stimulated discussions on the online platforms of the interventions [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]. Interactions with the coaches varied from single, daily, or regular monthly contact [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref87">87</xref>] to ad hoc, based on needs [<xref ref-type="bibr" rid="ref85">85</xref>].</p>
          <p>Some coaches were experienced in behavioral change methods [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref87">87</xref>], and 3 coaches applied motivational interviewing [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]. It is difficult to determine whether coaching led to increased effectiveness of the intervention. However in 3 studies, the coaching component seemed promising [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]. The coaching component was positively associated with intervention usage [<xref ref-type="bibr" rid="ref49">49</xref>] or higher engagement [<xref ref-type="bibr" rid="ref47">47</xref>]. Furthermore, several studies reported that participants with a low SES appreciated the coaches [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]. Moreover, in 1 study, after the coach stopped engaging on social media (eg, posting and commenting), intervention engagement considerably decreased and passive engagement increased [<xref ref-type="bibr" rid="ref56">56</xref>].</p>
        </sec>
        <sec>
          <title>Incentives</title>
          <p>Many studies [<xref ref-type="bibr" rid="ref23">23</xref>, <xref ref-type="bibr" rid="ref32">32</xref>, <xref ref-type="bibr" rid="ref34">34</xref>, <xref ref-type="bibr" rid="ref35">35</xref>, <xref ref-type="bibr" rid="ref38">38</xref>, <xref ref-type="bibr" rid="ref41">41</xref>, <xref ref-type="bibr" rid="ref45">45</xref>, <xref ref-type="bibr" rid="ref52">52</xref>, <xref ref-type="bibr" rid="ref53">53</xref>, <xref ref-type="bibr" rid="ref56">56</xref>, <xref ref-type="bibr" rid="ref71">71</xref>, <xref ref-type="bibr" rid="ref76">76</xref>, <xref ref-type="bibr" rid="ref79">79</xref>, <xref ref-type="bibr" rid="ref87">87</xref>] offered participants incentives (eg, gift cards) [<xref ref-type="bibr" rid="ref23">23</xref>, <xref ref-type="bibr" rid="ref32">32</xref>, <xref ref-type="bibr" rid="ref34">34</xref>, <xref ref-type="bibr" rid="ref35">35</xref>, <xref ref-type="bibr" rid="ref38">38</xref>, <xref ref-type="bibr" rid="ref41">41</xref>, <xref ref-type="bibr" rid="ref45">45</xref>, <xref ref-type="bibr" rid="ref52">52</xref>, <xref ref-type="bibr" rid="ref53">53</xref>, <xref ref-type="bibr" rid="ref56">56</xref>, <xref ref-type="bibr" rid="ref71">71</xref>, <xref ref-type="bibr" rid="ref76">76</xref>, <xref ref-type="bibr" rid="ref79">79</xref>, <xref ref-type="bibr" rid="ref87">87</xref>] for completing the assessments [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref87">87</xref>] to improve response rates [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref52">52</xref>], when submitting their saliva [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref87">87</xref>] or sending their self-monitoring data [<xref ref-type="bibr" rid="ref35">35</xref>]. Nonetheless, it is unclear whether incentives delivered positive results. In fact, Radhakrishnan et al [<xref ref-type="bibr" rid="ref53">53</xref>] found that the rewards and incentives offered in a game intervention did not match the real-time behavior, while in another study, participants suggested a greater frequency of incentives [<xref ref-type="bibr" rid="ref45">45</xref>].</p>
        </sec>
        <sec>
          <title>Tips</title>
          <p>Providing practical information as tips was mentioned in several studies [<xref ref-type="bibr" rid="ref23">23</xref>, <xref ref-type="bibr" rid="ref38">38</xref>-<xref ref-type="bibr" rid="ref40">40</xref>, <xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref45">45</xref>, <xref ref-type="bibr" rid="ref48">48</xref>, <xref ref-type="bibr" rid="ref49">49</xref>, <xref ref-type="bibr" rid="ref53">53</xref>, <xref ref-type="bibr" rid="ref54">54</xref>, <xref ref-type="bibr" rid="ref58">58</xref>, <xref ref-type="bibr" rid="ref60">60</xref>-<xref ref-type="bibr" rid="ref62">62</xref>, <xref ref-type="bibr" rid="ref64">64</xref>, <xref ref-type="bibr" rid="ref66">66</xref>, <xref ref-type="bibr" rid="ref68">68</xref>, <xref ref-type="bibr" rid="ref71">71</xref>, <xref ref-type="bibr" rid="ref75">75</xref>-<xref ref-type="bibr" rid="ref77">77</xref>, <xref ref-type="bibr" rid="ref79">79</xref>, <xref ref-type="bibr" rid="ref84">84</xref>-<xref ref-type="bibr" rid="ref88">88</xref>]. Various studies chose this practical component based on theories [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref75">75</xref>]. Participants appreciated tips or found it useful to receive practical solutions as tips [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]. However, tips have to fit into the socioeconomic and sociocultural realities of people with a low SES [<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]. It is unclear whether tips led to increased effectiveness of the intervention. However, Greene et al [<xref ref-type="bibr" rid="ref54">54</xref>] found that intervention use was significantly higher among those who found the “Tip of the Day” motivating.</p>
        </sec>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>This scoping review provides an overview of the most commonly applied components in eHealth lifestyle interventions (development, reach, use, evaluation, and implementation) for people with a low SES. It also investigates the most common barriers and facilitators for current eHealth lifestyle interventions. The components that emerged can be classified into behavioral components (such as basic theoretical foundation, coaching, social support, reminders, self-monitoring, and incentives) and technological components (such as visual multimedia, reminders, and self-monitoring). Nevertheless, we found considerable heterogeneity in components, barriers, and facilitators, showing significant variation between studies. Moreover, we believe that the majority of barriers and facilitators for development and use are related to technology (eg, technical difficulties) and environmental factors (eg, financial resources of the intervention developers or target group). However, there was limited reporting about the barriers or facilitators within specific interventions, partly because many authors did not always share the lessons learned within their interventions. We should note that the barriers and facilitators may not be generalizable across different lifestyle behaviors, and few may apply to all SES groups and not only to eHealth interventions for low SES groups.</p>
        <p>The studies examined the effectiveness of eHealth lifestyle interventions and showed promising but inconsistent results. They showed small effects of smoking cessation, nutrition, increased physical activity, and weight loss. These studies provided limited information about which components contributed to the effectiveness of the intervention, making it difficult to conclude why these interventions worked when compared to those that were unsuccessful. This is in line with the results of the systematic review by Kohl et al [<xref ref-type="bibr" rid="ref90">90</xref>], which found that effect sizes were small, variable, and unsustainable in eHealth lifestyle interventions for different SES populations and concluded that the efficacy of intervention elements were unclear.</p>
      </sec>
      <sec>
        <title>Different Delivery Methods</title>
        <p>The results of this review suggest that eHealth lifestyle interventions delivered via different delivery modes (ie, websites, SMS text messages, or apps) or combined with professional personal support seem to be accepted by people with a low SES. However, it is still unclear which delivery method is the most effective for this target group because each delivery mode has its advantages. Danaher et al [<xref ref-type="bibr" rid="ref91">91</xref>] and Iribarren et al [<xref ref-type="bibr" rid="ref92">92</xref>] suggested that interventions delivered via text messages may be an attractive option as they are inexpensive, suitable for most mobile phones, and require little user effort. Conversely, interventions delivered via websites or apps provide a visually pleasing option (ie, videos) for communicating the information and make the intervention interactive. However, it is crucial to consider the digital literacy levels of people with a low SES when choosing the delivery method of an intervention. Blended care (combination of face-to-face services with eHealth) offers people with a low SES timely guidance, which can promote engagement and adherence to the intervention. Therefore, we suggest that combinations of varied eHealth delivery modes and face-to-face elements (ie, human coaching) could engage people with a low SES successfully.</p>
      </sec>
      <sec>
        <title>Reaching the Low SES Group</title>
        <p>Overall, it was clear from the studies that it was difficult to reach low SES individuals for participation in eHealth interventions, which is typical for this group. Thus, a different approach to reach this group is crucial. For example, studies have been successful in reaching participants with active recruiting strategies, such as face-to-face or personal contact [<xref ref-type="bibr" rid="ref31">31</xref>]. The personal approach may reduce the distance between intervention staff and potential users, create a sense of security, and increase engagement [<xref ref-type="bibr" rid="ref93">93</xref>]. Long-term relationships build trust between health professionals and patients, and such an approach is needed to reach people with a low SES [<xref ref-type="bibr" rid="ref93">93</xref>,<xref ref-type="bibr" rid="ref94">94</xref>]. Moreover, with this rapport, individuals may perceive health professionals as more credible, especially within ethnic minorities [<xref ref-type="bibr" rid="ref94">94</xref>]. Another promising strategy is collaboration with the social network of people with a low SES (eg, caregivers, relatives, and experts) [<xref ref-type="bibr" rid="ref44">44</xref>]. Recent studies identified the importance of using a personal approach and connecting via existing networks (ie, community centers or ambassadors) to successfully recruit low SES populations for lifestyle interventions [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref93">93</xref>]. Furthermore, we found that social media may achieve this goal since it has a broad reach, but the lack of robust evidence makes it difficult to draw firm conclusions. Social media may be particularly effective to reach young people. However, reaching people with a low SES remains challenging as there is no clear reach strategy. A similar pattern of results was obtained in the systematic review by Bonevski et al [<xref ref-type="bibr" rid="ref95">95</xref>], which found that proven strategies to reach socially disadvantaged groups were rare. This highlights the importance of tailoring reach strategies, both online and offline, to target different types of groups (eg, young populations and ethnic minorities) within the low SES population. Lessons can also be drawn from traditional lifestyle interventions that provide insight into reaching low SES groups [<xref ref-type="bibr" rid="ref96">96</xref>].</p>
      </sec>
      <sec>
        <title>First Phase of Intervention Design and Co-creation</title>
        <p>We noted that few studies based their interventions on behavioral theories. When behavioral theories were reported, authors rarely elaborated on how they applied these theories. These results seem to be consistent with other research that found that behavioral theories were seldom applied in interventions [<xref ref-type="bibr" rid="ref88">88</xref>,<xref ref-type="bibr" rid="ref97">97</xref>,<xref ref-type="bibr" rid="ref98">98</xref>]. One possible explanation for this might be that intervention components are developed with a practical viewpoint in mind or a pre-existing belief in the benefit of these components, since they have been used previously in effective interventions [<xref ref-type="bibr" rid="ref98">98</xref>] Alternatively, it may be that certain behavioral theories were not found to be useful for the development of the intervention at hand and were therefore not applied [<xref ref-type="bibr" rid="ref99">99</xref>]. However, using theories in interventions has been indicated to increase their effectiveness.</p>
        <p>There are several issues to consider in the co-creation of eHealth interventions, such as how and when stakeholders and users get involved. In recent years, more attention has been paid to the role of stakeholders (including users) in public interventions; however, involving stakeholders (eg, people with a low SES and health professionals) from the beginning is time-consuming and expensive [<xref ref-type="bibr" rid="ref32">32</xref>]. Follow-up research needs to explore the best way to actively involve low SES individuals in developing and evaluating interventions, as co-creating with end users seems promising.</p>
      </sec>
      <sec>
        <title>Implementation</title>
        <p>The results of this review show that the development, evaluation, and implementation of eHealth are difficult to distinguish from each other and that the implementation of the intervention takes place during its development. As advocated by Pieterse et al [<xref ref-type="bibr" rid="ref100">100</xref>], eHealth development and implementation should be intertwined. Implementation should be accounted for from the start of the development process; this is especially true for people with a low SES, since their characteristics, such as low digital skills, may hinder the interventions’ implementation [<xref ref-type="bibr" rid="ref61">61</xref>].</p>
        <p>A shortage of resources is also known to impact implementation. These findings are directly in line with previous findings. For example, Lau et al [<xref ref-type="bibr" rid="ref101">101</xref>] and Ross et al [<xref ref-type="bibr" rid="ref102">102</xref>] found in their reviews that available resources, including time, funding, and staff, can be both barriers and facilitators in the implementation of interventions.</p>
      </sec>
      <sec>
        <title>Recommendation for Design and Research, and Limitations</title>
        <p>There are still unanswered questions in the development, reach, use, evaluation, and implementation of eHealth interventions for a low SES population, as the research is in its infancy. Using existing guidelines (eg, the CONSORT checklist) or other frameworks could guide in reporting information comprehensively and clearly [<xref ref-type="bibr" rid="ref29">29</xref>]. For instance, use of the behavior change technique taxonomy by Michie et al [<xref ref-type="bibr" rid="ref89">89</xref>] can help researchers to report on the behavioral theories and techniques applied in the intervention. Furthermore, it is vital to report more detailed information on how participants use the components of eHealth interventions, which may help identify elements that contribute to the effectiveness of eHealth interventions. This information could be beneficial for future studies and interventions as it can guide developers in the design and implementation of effective eHealth interventions. Another recommendation is to collaborate with researchers, developers, and stakeholders (including users) in the development, evaluation, and implementation of eHealth lifestyle interventions, to fine-tune these to the target group’s needs and requirements. Involving the social networks (eg, relatives and peers) of low SES participants in eHealth lifestyle interventions also seems promising. Research shows that engaging social networks can support low SES participants who experience problems with their digital skills [<xref ref-type="bibr" rid="ref60">60</xref>]. It is therefore important to investigate what role social networks should play within eHealth lifestyle interventions. Finally, although many studies advised making the content of eHealth interventions accessible to people with low skills, clear recommendations for developers and researchers on how eHealth interventions for low SES populations can be developed, implemented, and evaluated were lacking. Future research should focus on how we can devise holistic eHealth guidelines that can assist developers and researchers with the creation of eHealth interventions that take the capabilities and requirements of this target group into account.</p>
        <p>This review is the first to focus on state-of-the-art available knowledge about developing and evaluating eHealth lifestyle interventions, and reaching people with a low SES to realize behavioral change and improve health in these people. The barriers and facilitators that we found offer promising elements that eHealth developers can use as a toolbox to connect eHealth with low SES target groups. Further research on the method of using these tools is still needed. However, this review has some limitations. First, we only included studies on eHealth interventions that focused on lifestyle behaviors and excluded studies on interventions aimed at other relevant areas for low SES individuals (mental health, and medical, legal, and financial issues). These interventions may provide additional insights. Second, as the primary focus was to gain insight into how eHealth lifestyle interventions are developed and evaluated for low SES individuals, we did not assess the quality of the studies and their results (ie, systematic review). Finally, we focused on the low SES group in general and did not distinguish between subgroups. Although ethnicity is not an indicator of SES, ethnic minorities (eg, non-Western immigrants and African American individuals) were often mentioned as prominent groups in the studies. It is therefore important to consider the differences within the low SES population, with the aim of not further increasing health disparities.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>This scoping review provides an overview of the available scientific knowledge on the behavioral and technological components, barriers, and facilitators in the development, evaluation, and implementation of eHealth lifestyle interventions. Although eHealth intervention development is diverse, contributing to the varying results in this review, certain factors may be beneficial for building and using eHealth interventions and reaching people with a low SES. Iterative design of interventions, use of visual and multimedia elements, and social support seem to be important facilitators for eHealth interventions. Technical challenges using eHealth interventions, lack of time in low SES groups, and limited resources appear to be key barriers for eHealth interventions. Understanding these barriers and facilitators may generate insights into how to optimize eHealth interventions for people with a low SES. Developing eHealth interventions for people with a low SES requires consideration of their specific needs and characteristics, and the involvement of users. This may contribute to the use of interventions and may facilitate their implementation.</p>
        <p>Guidelines should be developed to aid stakeholders in developing and evaluating eHealth interventions. Moreover, high-quality studies are needed to investigate how eHealth lifestyle interventions can be customized to meet the needs of participants with a low SES. Future studies could benefit significantly from detailed reporting on eHealth interventions for this target group.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>Full search strings per database.</p>
        <media xlink:href="jmir_v24i8e34229_app1.doc" xlink:title="DOC File , 252 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Key constructs and definitions for data extraction.</p>
        <media xlink:href="jmir_v24i8e34229_app2.doc" xlink:title="DOC File , 32 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Overview of included publications (characteristic studies and theories).</p>
        <media xlink:href="jmir_v24i8e34229_app3.xlsx" xlink:title="XLSX File  (Microsoft Excel File), 24 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">CeHRes</term>
          <def>
            <p>Center for eHealth Research</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">RCT</term>
          <def>
            <p>randomized controlled trial</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">RE-AIM</term>
          <def>
            <p>reach, effectiveness, adoption, implementation, and maintenance</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">SES</term>
          <def>
            <p>socioeconomic status</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>We acknowledge support from Medical Delta (MD 2.0 program), ZonMw (The Netherlands Organization for Health Research and Development), and the Netherlands Cardiovascular Research Initiative, an initiative with support of the Dutch Heart Foundation (CVON2016-12 BENEFIT). We would like to thank the librarian Jan W Schoones at Leiden University Medical Centre (LUMC) for his contribution to the development of the search strategy. We would like to thank Mike Keesman, PhD, for his valuable inputs during the initial phase of the research.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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