The Web of Science (WoS) Core Collection database was searched on September 16, 2020 and queried with the following search string: TOPIC: (“virtual reality*” OR “augmented reality*” OR “mixed reality*” OR “computer-mediated reality*”) AND TOPIC: (medic* OR illness* OR disease* OR health* OR pharma*). The search identified publications mentioning these words and their derivatives in the title, abstract, or keywords. No additional restrictions, such as publication type or language, were used. The “Analyze” and “Create Citation Report” functions of WoS were utilized for basic publication and citation counting. The full records of the resultant publications were exported to VOSviewer (version 1.6.15) and Bibliometrix (Version 3.0 operated under the web interface called Biblioshiny) for further bibliometric analyses.

VOSviewer was used to produce a term map showing phrases from titles and abstracts of the publications. For clarity, phrases occurring in at least 0.5% (42/8399) of the publications were included. Multiple appearances in a single publication counted as one. In the obtained map, the circle size represents the frequency of occurrence, whereas the color represents the citations per publication. The distance between 2 circles represents how 2 phrases co-occurred with each other in the publications. Meanwhile, a density map was produced to show author´s keywords in the publications. For clarity, keywords occurring in at least 0.1% (9/8399) of the publications were included. A keyword or cluster of keywords with higher frequency counts formed a red region, and those with lower frequency counts formed a yellow region.

Utilizing the software Biblioshiny, the Trend Topics function was used to reveal trends in abstract words. Words were included if they occurred in at least 5 publications. Each year was limited to 5 words.

To analyze citation per publication (CPP) differences between original articles and reviews as well as between core and noncore journals, a 2-sample t test was conducted. In order to assess differences in CPP between different research areas (as designated by WoS), a one-way analysis of variance was utilized. Statistical tests were performed with SPSS (version 26.0; IBM Corp, Armonk, NY). Results were deemed significant if P<.05.

The literature search identified 8399 publications published from 1992 until 2020. The annual publication count reached 100 since 2005 and exceeded 1000 since 2018 (Figure 1). The year 2020 had 802 published papers until the date of the literature search (9/16/2020). There were 5297 original articles (5297/8399, 63.07%; CPP=17.4) and 902 reviews (902/8399, 10.74%; CPP=31.1). Therefore, the article-to-review ratio was 5.9:1, with reviews having a significantly higher CPP than original articles (P<.001). Other major document types were proceedings papers (1908/8399, 22.72%; CPP=2.0; WoS tagged 2213, of which 305 were simultaneously tagged as original articles), editorial materials (135/8399, 1.61%; CPP=13.7), and meeting abstracts (130/8399, 1.55%; CPP=0.2). The analyzed papers were mainly published in English (8131/8399, 96.81%).

The 10 most productive authors by number of publications are listed in Table 1. The most productive author was Professor Giuseppe Riva from General Psychology and Communication Psychology, Catholic University of Milan, Italy. He also had the highest H-index among the 10 most productive authors. Meanwhile, the author with the highest CPP was Professor Albert “Skip” Rizzo from Medical Virtual Reality, Institute for Creative Technologies, University of Southern California. From the M-index, it was noted that among these authors, the most impactful newcomer to the field was Dr Silvia Serino from MySpace Lab, Department of Clinical Neurosciences, University Hospital Lausanne, Switzerland.

The 10 most productive organizations are listed in Table 2; 5 of these were in the United States, 2 each in the United Kingdom and Italy, and 1 in Canada. The University of London was the most productive organization, and the University of Toronto had the highest CPP, whereas the earliest research in this field was published at Harvard University.

The 10 most productive countries are listed in Table 3. The United States had contributions to nearly 30% of the VR publications in medicine and had the highest CPP. The international collaboration rates of these countries were mostly around 20%-30%, with the United States having a lower rate at 12.3%.

The 10 most productive journals are listed in Table 4. Computer science, surgery, and psychology were the 3 major research areas of these productive journals. Among the list, computer science journals seemed to have much lower CPP compared to others. According to Bradford’s law, core journals are defined as the most productive journals that collectively account for publishing one-third of all concerned articles [25]. By this definition, there were 85 core and 3565 noncore journals in this dataset. The CPP of core (14.8) and noncore (15.0) journals did not significantly differ (P=.845).

When the research area (of journals) was examined, the top 6 areas in descending order of publication count were computer science (CS), engineering (En), neurosciences and neurology (Neuro), surgery (Surg), psychology (Psy), and rehabilitation (Rehab). The CPPs of these 6 groups were significantly (P<.001) different from each other. Post-hoc tests revealed that the CPPs of Surg (25.1, SD 40.0), Psy (19.0, SD 35.6), and Neuro (20.3, SD 44.1) were greater than those of En (8.5, SD 26.8) and CS (9.5, SD 76.0); Surg was greater than that of Rehab (12.3, SD 24.5); and Others (15.6, SD 57.5) was greater than those of CS and En. Since some journals can be assigned to multiple research areas, a mutual exclusion procedure was performed in reverse hierarchical order (ie, the Rehab group retained all relevant papers first, then the Psy group retained all relevant papers excluding those coassigned to the Rehab group, then the Surg group retained all relevant papers excluding those coassigned to the Rehab and Psy groups, and so on). Finally, the Others group consisted of papers not assigned to the other 6 groups. In summary, papers dealing with clinical topics of surgery, neurosciences, psychology, and rehabilitation generally had more citations than those dealing with topics of computer science and engineering. This is consistent to a previous study in which neurosciences and surgery were among the top scientific categories with high citations [26].

VOSviewer was used to generate a term map that tagged the phrases mentioned in the titles and abstracts of the publications with their CPPs (Figure 2). Phrases located in the upper part of the figure generally had higher CPPs. They were mainly related to surgery, such as laparoscopic skill (95/8399, CPP=29.9), surgical skill (190/8399, CPP=35.9), surgical training (195/8399, CPP=29.1), and surgical simulation (103/8399, CPP=26.5). Bibliometrix was used to illustrate the temporal changes in the abstract words (Figure 3). The most common words in the 2000s were related to diagnostic procedures such as angiographic, echocardiographic, ureteroscopy, and colonoscopy. In the 2010s, the most common words were related to brain diseases and mental health disorders, such as schizophrenia, AD (Alzheimer’s disease), and ASD. Table 5 lists the medical conditions mentioned in at least 0.5% (42/8399) of the titles and abstracts of publications of VR research in medicine. This list was enriched with neuropsychological (eg, anxiety, depression), neurophysiological (eg, pain), and neuropathological (eg, Parkinson, Alzheimer) conditions and diseases.

Author keywords also revealed that rehabilitation and simulation were the 2 major foci. As seen in Figure 4, the former was centered by words related to aging and neurodegenerative problems, such as Parkinson’s disease (PD), stroke, dementia, gait, and cognition. The latter was centered by words related to surgery and education, such as surgical training, image-guided surgery, virtual patient, and robotic surgery. There were also other words related to emotion and perception, such as anxiety, stress, and pain, which occupied subclusters with lower frequency densities. The 10 author keywords with the highest frequencies and CPPs are listed in Table 6.

The highest frequency keyword was simulation. Table 7 lists the 10 most cited papers that mentioned “simulation” in their keywords. Besides laparoscopic skills, the use of simulation in general medical education was also covered in terms of implementation issues, availability of products on the market, and recommendations.

The use of AR can be facilitated by many related technologies, for example, wearable tactile sensors [37] and skin-like electronics [38]. In surgery, AR can enhance the surgeon’s vision by offering a virtual transparency of the patient [39]. When learning anatomy, AR can create an illusion that allows the display of internal anatomical structures on the body of the user [40]. These cases illustrate the versatility of AR.

This bibliometric analysis of 8399 publications on VR research in medicine revealed that the field began to develop in the 1990s, grew in the 2000s, and has been thriving in the 2010s in terms of both publications and citation counts. Original articles accounted for 63.1% of the literature. The article-to-review ratio was 5.9:1.

The literature had global contributions not only from North America and Europe but also from Asia and Oceania, implying that the application of VR in medicine has attracted worldwide attention. Diagnostic and surgical procedures as well as rehabilitation in neurodegenerative and mental health disorders were major research themes.

The use of VR simulators helped in diagnostic and surgical procedures, such as improving novice hospital residents’ laparoscopic skills in terms of error and procedure time reduction [28]. It was also used to assess the suturing skills of different groups of operators [41]. In surgery, it was suggested that VR and simulation could be of value for 4 aspects, namely training and education, surgical planning, image guidance, and telesurgery [42].

Geriatrics has been exploring the use of VR tasks to assess and train episodic memory in the elderly population, by simulating various environments representative of daily life that cannot be physically replicated in the clinic or rehabilitation centers [43]. The use of VR might also help rehabilitation clinicians conduct telerehabilitation on a remote basis so that the patient (eg, after stroke) carries out exercises at home in a virtual environment and data are then transmitted to the clinician [44]. Moreover, VR could incorporate gamified elements so that the process could be more rewarding (eg, for encouraging patients with PD to do more remotely supervised aerobic exercise) [45]. Nonimmersive VR has also been used to add cognitive challenges and virtual obstacles to treadmill training for older adults, targeting attention, perception, and dual tasking during walking with the aim to reduce fall risk [46]. Since the existing studies were quite diverse, more studies should be conducted to optimize the implementation and evaluate the beneficiary effects in different population groups, so that a recommendation can be made for how to use VR in cognitive rehabilitation [47].

Meanwhile, the use of immersive VR was beneficial in managing a spectrum of emotional problems, such as the fear of heights [48], anxiety disorders [17], depression [49], and ASD [50]. Immersive VR could also reduce pain in patients, such as those with severe burn injuries during wound care [51] and pediatric patients during invasive medical procedures [52,53]. Two functions of VR for this category are distraction [54] and creation of presence [55,56]. Whereas the former distracts the subject from the real-world situation, such as pain-inducing medical procedures, the latter enables the subject to “experience” designed scenarios to facilitate management strategies such as cognitive reappraisal or cognitive behavioral therapy.

To the authors’ knowledge, no previous bibliometric analysis on VR research in the medicine literature overall has been published. A bibliometric analysis of VR research in general (including nonmedical areas) by Cipresso et al [2] similarly revealed the dominance by the United States, United Kingdom, Germany, and China in this research field [2]. Five authors in the top 10 list of this study were also in the top 10 list of Cipresso et al [2], namely Giuseppe Riva, Brenda K. Wiederhold, Albert “Skip” Rizzo, Cristina Botella, and Mariano Alcaniz. This implies that medicine might be among the most important scientific areas for applications of VR in general. The general VR research literature covered broader aspects apart from the research areas reported here and had large shares from mathematical and computational biology, radiology, and social sciences [2]. For VR research in ASD, the United States accounted for 51.2% of all publications, followed by the United Kingdom (16.5%), India, Spain, and China (3%-5% each) [57]. VR research in rehabilitation was similarly led by the United States (29.8%) and the United Kingdom (9.0%), followed by Italy (7.7%), Canada (7.4%), and Germany (5.1%) [58]. Meanwhile, the United Kingdom was most productive in VR research in dementia (43.2%), followed by the United States (39.5%), France (33.5%), Switzerland (28.6%), Germany, Greece, and Italy (23.2% each) [24].

A bibliometric analysis of artificial intelligence research in health and medicine similarly found that the United States was the top contributing country (30.8% versus 29.3% in this VR report) [59]. While China and Italy were the second and third most productive countries in artificial intelligence research in medicine, the United Kingdom did not enter the top 20 list. Here, for VR research in medicine, China and Italy were sixth and fifth on the list, whereas the United Kingdom ranked second. Both fields seemed to have different diseases of interest, but both shared stroke, cancer, AD, and PD [59].

The current work searched one literature database only, implying that some papers could inevitably have been missed. However, as different databases record citation counts differently, it would be impossible to merge data from multiple databases. Moreover, publication and citation counts might not directly reflect the scientific quality of the papers, which might be influenced by various parameters including the sample size, study design, and standard of reporting. These would be best addressed by a systematic review with a focused scope, whereas the current work used bibliometric approach reports on the overall landscape of the literature in the research field.

Literature in the field of VR research in medicine represented over 8000 publications. The analyzed literature had global contributions with the heaviest contributions from the United States and United Kingdom. More clinically related research areas such as surgery, psychology, neurosciences, and rehabilitation had higher average numbers of citations than computer science and engineering. Diagnostic and surgical procedures and rehabilitation were major research themes. Medical conditions commonly investigated were pain, stroke, anxiety, depression, fear, cancer, and neurodegenerative disorders. The high potential and diversity of applications of VR and AR in medicine are already highly visible, and further improvements in these technologies are expected to both enhance their functionality and make them more accessible to patients, which will finally translate to significant therapeutic or preventive impact.