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<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="review-article" dtd-version="2.0">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v23i12e23804</article-id>
      <article-id pub-id-type="pmid">34860664</article-id>
      <article-id pub-id-type="doi">10.2196/23804</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Learning and Use of eHealth Among Older Adults Living at Home in Rural and Nonrural Settings: Systematic Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Kukafka</surname>
            <given-names>Rita</given-names>
          </name>
        </contrib>
        <contrib contrib-type="editor">
          <name>
            <surname>Eysenbach</surname>
            <given-names>Gunther</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Cheng</surname>
            <given-names>Christina</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Estrin</surname>
            <given-names>Deborah</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Airola</surname>
            <given-names>Ella</given-names>
          </name>
          <degrees>MEd</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Media Education Hub</institution>
            <institution>Faculty of Education</institution>
            <institution>University of Lapland</institution>
            <addr-line>P.O. Box 122</addr-line>
            <addr-line>Rovaniemi, FI-96101</addr-line>
            <country>Finland</country>
            <phone>358 44 4744389</phone>
            <email>ella.airola@ulapland.fi</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-4221-6980</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Media Education Hub</institution>
        <institution>Faculty of Education</institution>
        <institution>University of Lapland</institution>
        <addr-line>Rovaniemi</addr-line>
        <country>Finland</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Ella Airola <email>ella.airola@ulapland.fi</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <month>12</month>
        <year>2021</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>2</day>
        <month>12</month>
        <year>2021</year>
      </pub-date>
      <volume>23</volume>
      <issue>12</issue>
      <elocation-id>e23804</elocation-id>
      <history>
        <date date-type="received">
          <day>24</day>
          <month>8</month>
          <year>2020</year>
        </date>
        <date date-type="rev-request">
          <day>25</day>
          <month>10</month>
          <year>2020</year>
        </date>
        <date date-type="rev-recd">
          <day>23</day>
          <month>11</month>
          <year>2020</year>
        </date>
        <date date-type="accepted">
          <day>14</day>
          <month>10</month>
          <year>2021</year>
        </date>
      </history>
      <copyright-statement>©Ella Airola. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 02.12.2021.</copyright-statement>
      <copyright-year>2021</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://www.jmir.org/2021/12/e23804" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>Care policies emphasize deinstitutionalization and <italic>aging in place</italic> in response to demographic changes. Different eHealth technologies are one way to achieve this aim. However, there is a need to better understand older adults’ needs for eHealth services, and thus, these health solutions require further exploration.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>The purpose of this systematic literature review is to appraise, synthesize, and summarize the literature on older adults’ (aged ≥60 years) eHealth learning and use in real home settings, particularly in rural and remote areas, with a focus on the social and cultural context.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>A systematic search was conducted in January 2020 using 4 academic databases. The studies by means of qualitative thematic analysis to identify the barriers, enablers, and support practices involved in the domestication process were examined. In addition, we identified the various meanings attached to eHealth technologies for older adults living in rural and remote areas.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>In total, 31 empirical studies published between 2010 and 2020 were included in this review. A total of 17 articles included participants from rural and remote areas. The most regularly reported barriers related to older adults’ learning to use and use of eHealth were health-related difficulties, such as cognitive impairment or impaired hearing. The most reported enabler was the support provided for older adults in learning and use of eHealth. Support mainly comprised older adults’ own digital competences, which were distributed with their social network. It was found that eHealth technology is needed for rural and remote areas to facilitate access and reduce logistical barriers to health care services.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>The literature review provided information and practical implications for designers, health care providers, and policy makers. On the basis of these findings, eHealth technologies should be easy to use, and adequate support should be provided to older adults for use.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>aged</kwd>
        <kwd>barrier</kwd>
        <kwd>digital competence</kwd>
        <kwd>deinstitutionalization</kwd>
        <kwd>eHealth</kwd>
        <kwd>home care</kwd>
        <kwd>learning</kwd>
        <kwd>older adult</kwd>
        <kwd>rural health</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>The aim of this systematic literature review is to advance the understanding of older adults’ (aged ≥60 years) eHealth learning and use during its domestication. The main target is older adults living in rural and remote environments, as they are far removed from traditional health care services [<xref ref-type="bibr" rid="ref1">1</xref>-<xref ref-type="bibr" rid="ref4">4</xref>]. According to the World Health Organization, health is understood as “a state of complete physical, mental, and social well-being and not merely the absence of disease of infirmity” [<xref ref-type="bibr" rid="ref5">5</xref>]. As a general practice, eHealth can be seen as an umbrella concept for different health care services delivered or improved through information and communication technologies (ICTs) [<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref7">7</xref>].</p>
        <p>On the basis of future demographic changes, the world will face two challenges: a growing care burden per capita and organizational changes to health care systems [<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref9">9</xref>]. To achieve its sustainable development goals, the United Nations [<xref ref-type="bibr" rid="ref8">8</xref>] has outlined key policy changes that deal with current and future population dynamics. Recommendations include investing in life-long learning, especially digital competences, and promoting healthy aging and long-term care systems to meet the needs of the aging population. Care policy throughout Europe has emphasized deinstitutionalization and <italic>aging in place</italic> to reduce paternalistic care and improve the quality of care [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref11">11</xref>]. Furthermore, previous research in many cultural settings has found that older adults prefer living at home for as long as possible [<xref ref-type="bibr" rid="ref9">9</xref>].</p>
      </sec>
      <sec>
        <title>Theoretical Framework</title>
        <p>This study’s theoretical framework is built on the concept of <italic>distributed and situated digital competence</italic>, <italic>technology domestication,</italic> and previous research on <italic>barriers and enablers</italic> of technology use. The European Commission’s <italic>DigComp 2.0: The Digital Competence Framework for Citizens</italic> [<xref ref-type="bibr" rid="ref12">12</xref>] defines digital competence as a combination of knowledge, skills, and attitudes related to the use of ICT tools. One competence is the protection of health and well-being, which means, for example, being aware of digital technologies that can be used to enhance social well-being and social inclusion. However, the framework can be criticized for being decontextualized and centered around individuals. Therefore, a socially and culturally oriented approach is followed, and digital competences are understood as the distributed and situated competences of older adults and their social networks [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref14">14</xref>].</p>
        <p>The concept of domestication focuses on how technology users and nonusers adopt technologies culturally and socially in their everyday lives [<xref ref-type="bibr" rid="ref15">15</xref>-<xref ref-type="bibr" rid="ref17">17</xref>]. The domestication of technology includes four dimensions: appropriation, objectification, incorporation, and conversion. The process starts with appropriation, which does or does not create a relationship with the new technology, and continues to objectification, which is when the technology is given a place at home. Incorporation focuses on the technology’s place in and influence over the user’s everyday routines. Finally, the technology becomes familiar, and conversion is achieved [<xref ref-type="bibr" rid="ref15">15</xref>-<xref ref-type="bibr" rid="ref21">21</xref>]. Central to domestication are the public and personal meanings attached to the technology, which actively transform during the process [<xref ref-type="bibr" rid="ref19">19</xref>]. Meanings are understood as individuals’ thoughts and feelings regarding the technology and how it is seen as part of his or her own cultural context [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>].</p>
        <p>Research into health-related barriers has found that the key reasons older adults avoid ICT adoption are the accessibility of support, their health status, lack of need or interest, functionality, added value, cost, and concerns regarding privacy and trust [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref25">25</xref>]. In the present review, barriers were not understood as insurmountable obstacles but rather as challenges that can be solved. Conversely, the following key enablers influence older adults’ use of eHealth: motivation, support, and feedback [<xref ref-type="bibr" rid="ref26">26</xref>]. In addition, meaningful function and aesthetics are important when older adults adopt technology [<xref ref-type="bibr" rid="ref27">27</xref>].</p>
      </sec>
      <sec>
        <title>Objective</title>
        <p>Recent international literature reviews on eHealth and older adults focus on a variety of topics: eHealth access and use from a health equity perspective [<xref ref-type="bibr" rid="ref28">28</xref>], the facilitators of and barriers to eHealth use [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref29">29</xref>], and user involvement in technology design, including eHealth technologies [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref31">31</xref>]. In addition, Cheng et al [<xref ref-type="bibr" rid="ref32">32</xref>] published a systematic review of eHealth interventions targeted at socially disadvantaged groups, including older adults. However, we still lack a review that examines older adults’ eHealth learning and use in real home settings and in a rural context from users’ perspectives. The purpose of the present review is to fill this gap by focusing on studies that report barriers and enablers that older adults face when learning to use and while using eHealth technology and how older adults are supported during the process. In addition, what eHealth technology means to older adults in rural and remote areas was examined. In reviewing relevant studies, this research seeks to answer the following questions:</p>
        <list list-type="order">
          <list-item>
            <p>What barriers and enablers are related to the learning and use of eHealth technologies in domestication processes among older adults living at home?</p>
          </list-item>
          <list-item>
            <p>How are older adults living at home supported in their domestication of eHealth technologies?</p>
          </list-item>
          <list-item>
            <p>What are the meanings attached to eHealth technologies for older adults living in rural and remote areas?</p>
          </list-item>
        </list>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Overview</title>
        <p>The methodology follows the standard PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for studies that evaluate health care research [<xref ref-type="bibr" rid="ref33">33</xref>]. PRISMA includes a 27-item checklist (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref> [<xref ref-type="bibr" rid="ref33">33</xref>]) and a 4-phase diagram (<xref rid="figure1" ref-type="fig">Figure 1</xref>) to help authors ensure clarity and transparency. A systematic literature review was selected “to appraise, synthesize, and summarize” [<xref ref-type="bibr" rid="ref34">34</xref>] the literature and determine whether further primary research in the area is needed. The entire review process was undertaken by 1 author, and there were no additional authors.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>Flow of information through the different phases of the systematic review.</p>
          </caption>
          <graphic xlink:href="jmir_v23i12e23804_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Search Strategy</title>
        <p>To begin the search process, the author consulted an information specialist at her university library regarding search phrases and relevant databases. A literature search was conducted in January 2020 and included the following international web-based databases: ProQuest (ERIC—Education Collection, Social Science Database, Applied Social Sciences Index and Abstracts, Sociological Abstracts, and Sociology Database), Ebsco (AgeLine, Academic Search Elite, and CINAHL Complete), Web of Science (Arts and Humanities Citation Index, Social Sciences Citation Index, Science Citation Index Expanded, and Emerging Sources Citation Index), and Scopus (Elsevier). Relevant articles were found using the search terms specified in <xref ref-type="boxed-text" rid="box1">Textbox 1</xref> and their combinations. An example search string used to search Scopus (Elsevier) can be found in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>. The search was applied to the field title, abstract, and keywords. Although the conversions around eHealth began at the turn of the millennium [<xref ref-type="bibr" rid="ref6">6</xref>], the review’s start date of 2010 was chosen as there has been a lot of change in health technologies over the past decade [<xref ref-type="bibr" rid="ref35">35</xref>]. The initial database search yielded 3612 papers (n=393, 10.88% from ProQuest, n=394, 10.91% from Ebsco, n=2767, 76.61% from Web of Science, and n=58, 1.61% from Scopus). No articles were included that were identified from sources other than the abovementioned databases.</p>
        <boxed-text id="box1" position="float">
          <title>Content and search terms of literature search. During the search, some terms were truncated using “*” so the search considers all the results including the first part of the word. For example, by searching <italic>learn*</italic>, the search also considers terms <italic>learner</italic> and <italic>learning</italic>.</title>
          <p>
            <bold>Content and search terms</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Older people:<italic> older, senior, elderly, aged people, old age user, elder</italic></p>
            </list-item>
            <list-item>
              <p>Rural: <italic>rural, remote, sparsely populated area</italic></p>
            </list-item>
            <list-item>
              <p>Use: <italic>education, learn*, competence, digital skill, geragogy, use, reject, active aging, adoption, acceptance, barrier, enabler, facilitator</italic></p>
            </list-item>
            <list-item>
              <p>Digital technology: <italic>online, ICT, information, computer, internet, electronic, techolog*, digital, smart, management tool, virtual, mobile, robot, tele*, monitoring, assist*, gerontechology, compliance, reminder, dispens*, video, application, device</italic></p>
            </list-item>
            <list-item>
              <p>Health: <italic>health, care, wellbeing, physical, mental, social</italic></p>
            </list-item>
            <list-item>
              <p>Home: <italic>aging in place, independent, home, everyday life, living, daily life, domestication</italic></p>
            </list-item>
          </list>
        </boxed-text>
      </sec>
      <sec>
        <title>Study Selection</title>
        <p><xref rid="figure1" ref-type="fig">Figure 1</xref> shows a flowchart depicting how PRISMA was used to select the studies. All articles were exported to Refworks (ProQuest), a reference management system that automatically discards duplicate papers. Of the 3612 papers, the removal reduced the number of papers to 3115 (86.24%). The remaining articles were screened for title, abstract, and keywords to select studies relevant to the research topic. Following the screening of the 3115 articles, a total of 489 (15.7%) articles were obtained. The remaining articles were exported to NVivo 12 (QSR International), a qualitative data analysis software, and the remaining duplicates were manually discarded. Full-text articles were then assessed for eligibility based on the preliminary inclusion and exclusion criteria.</p>
        <p>Finally, full-text articles (31/489, 6.3%) that met the following criteria (<xref ref-type="boxed-text" rid="box2">Textbox 2</xref>) were accepted: published in a peer-reviewed scientific journal; written in English; published between January 1, 2010, and January 22, 2020; had an empirical study design aimed at supporting older adults’ use of eHealth technology in real home settings at the user’s home; completely or partially focused on technology users’ perspectives; had participants with a mean age of 60 years; and included participants who were older adults with or without health conditions. Initially, the aim was to select studies that included only older adults aged &#62;65 years, which is a common age limit for older adults in research [<xref ref-type="bibr" rid="ref36">36</xref>]; however, because of the low number of studies, the age range was extended to a mean of 60 years. In addition, living in rural or remote areas was a planned inclusion criterion; however, it was modified to living in any area, as not enough studies met the original criterion. However, one research question focused only on studies conducted in rural and remote areas.</p>
        <boxed-text id="box2" position="float">
          <title>Inclusion and exclusion criteria.</title>
          <p>
            <bold>Inclusion criteria</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Academic paper published in a peer-reviewed scientific journal</p>
            </list-item>
            <list-item>
              <p>Written in English</p>
            </list-item>
            <list-item>
              <p>Published between 2010 and 2020</p>
            </list-item>
            <list-item>
              <p>Had an empirical study design aimed at supporting older adults’ eHealth use</p>
            </list-item>
            <list-item>
              <p>Was located in real home settings at the user’s home</p>
            </list-item>
            <list-item>
              <p>Had participants with a mean age of 60 years</p>
            </list-item>
            <list-item>
              <p>Completely or partially focused on users’ perspectives</p>
            </list-item>
          </list>
          <p>
            <bold>Exclusion criteria</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Did not include older adult participants</p>
            </list-item>
            <list-item>
              <p>Was not conducted in real home settings</p>
            </list-item>
            <list-item>
              <p>Was conducted in a laboratory or included no user experience with eHealth</p>
            </list-item>
            <list-item>
              <p>Was a review or theoretical study</p>
            </list-item>
            <list-item>
              <p>Only had a biomedical or technical perspective</p>
            </list-item>
          </list>
        </boxed-text>
      </sec>
      <sec>
        <title>Data Exclusion and Analysis</title>
        <p>For the final set of full-text articles, a data extraction sheet was developed (<xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref> [<xref ref-type="bibr" rid="ref37">37</xref>-<xref ref-type="bibr" rid="ref65">65</xref>]). The gathered data included information on article titles, authors, journals, publication years, methods, eHealth technologies, target groups, total number of participants, participant genders and ages, participants’ area of residence (eg, rural or remote), and countries of residence. The included articles were analyzed in NVivo 12 using a qualitative thematic approach guided by the concepts of domestication and digital competence. In addition, previous research on the barriers to and enablers of technology use was used. The author thoroughly read and reread the articles and identified 154 subcategories that described significant sentences and phrases concerning the research questions. The obtained subcategories were clustered into 8 upper-level categories to produce a more nuanced understanding.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Study Characteristics</title>
        <p>The selected 31 articles were published in 29 different journals representing multidisciplinary research. Of the 31 papers, 16 (52%) were quantitative, 4 (13%) were qualitative, and 11 (35%) were mixed methods studies. Most studies used &#62;1 method; only 16% (5/31) used just one method. The most common qualitative data collection methods were surveys and questionnaires (20/31, 65%) and technical logs (12/31, 39%). The most common qualitative data collection methods were interviews (9/31, 29%) and focus groups (5/31, 16%). The studies were conducted in the following 12 countries: the United States (9/31, 29%), Canada (2/31, 6%), Italy (2/31, 6%), Spain (2/31, 6%), Sweden (2/31, 6%), the United Kingdom (2/31, 6%), France (1/31, 3%), Germany (1/31, 3%), Ireland (1/31, 3%), Lebanon (1/31, 3%), Norway (1/31, 3%), and Switzerland <italic>(</italic>1/31, 3%). In 19% (6/31) of studies, the country was not identified.</p>
        <p>The number of participants ranged from 1 to 4380, although not all were older adults. In all articles, either the mean or median age and SD or the age range was defined. However, in studies in which only the SD and mean or median age were given, it was not possible to strictly count the age of the youngest and oldest participants. In 90% (28/31) of articles, the mean or median age of the technology users was ≥60 years, and in 39% (12/31) of articles, the minimum age was &#62;60 years. Some articles (6/31, 19%) included technology users aged&#60;50 years, and it was possible to separate them from the older adults in the findings. This means that the findings were still based on participants who were aged &#62;60 years or whose mean or median age was ≥60 years. In 42% (13/31) of articles, most participants were women, and in 35% (11/31) of articles, most participants were men. In 6% (2/31) of papers, female and male participants were equally represented, and in 16% (5/31) of papers, gender was not defined.</p>
        <p>All participants used eHealth technologies in real home settings. The eHealth technologies that occurred most frequently were mobile apps (18/31, 58%), monitoring systems (12/31, 39%), web-based platforms (11/31, 35%), assistive technologies (2/31, 6%), and ambient awareness technology (1/31, 3%). No eHealth robots were included in this study. Most technologies were targeted at older adults with different noncommunicable diseases. Of those, the largest target groups were cardiac disease (5/31, 16%), diabetes (3/31, 10%), and cancer (3/31, 10%). In total, 2 technologies were used for older adults with polypharmacy issues and 2 for those in palliative care. In 16% (5/31) of studies, eHealth technologies were aimed at isolated older adults, and in 13% (4/31) of studies, the technology was for older adults with depression, anxiety, or apathetic qualities. In total, 1 eHealth technology was only for healthy older adults, and 5 were for older adults or adults of any age group in general. In some studies, the participants were veterans (4/31, 13%), and in others, they were older family caregivers (4/31, 13%).</p>
      </sec>
      <sec>
        <title>Barriers and Enablers in the Domestication Process</title>
        <sec>
          <title>Overview</title>
          <p>The first research question focused on the barriers and enablers related to the learning and use of eHealth technologies in the domestication process among older adults living at home. Thematic analysis produced 111 subcategories related to these barriers and enablers. The subcategories were clustered into 4 dimensions of the domestication process [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref17">17</xref>]: appropriation (40/111, 36%), objectification (10/111, 9%), incorporation (27/111, 24.3%), and conversion (34/111, 30.6%). A summary of these findings is presented in <xref ref-type="table" rid="table1">Tables 1</xref> and <xref ref-type="table" rid="table2">2</xref>.</p>
          <table-wrap position="float" id="table1">
            <label>Table 1</label>
            <caption>
              <p>Summary of the findings concerning the barriers to learning and use of eHealth technologies among older adults (N=31).</p>
            </caption>
            <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
              <col width="30"/>
              <col width="30"/>
              <col width="700"/>
              <col width="0"/>
              <col width="240"/>
              <thead>
                <tr valign="top">
                  <td colspan="4">Dimension of domestication and barriers</td>
                  <td>Papers, n (%)</td>
                </tr>
              </thead>
              <tbody>
                <tr valign="top">
                  <td colspan="5">
                    <bold>Appropriation</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>eHealth technology</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Lack of connectivity</td>
                  <td colspan="2">9 (29)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Technical problems</td>
                  <td colspan="2">8 (26)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Difficult to use</td>
                  <td colspan="2">6 (19)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Unclear instructions</td>
                  <td colspan="2">5 (16)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Cost</td>
                  <td colspan="2">4 (13)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Technical limitations</td>
                  <td colspan="2">4 (13)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Difficult to learn to use</td>
                  <td colspan="2">3 (10)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>No feedback</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Lack of effectiveness</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Lack of technical device</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Technology was unexpected</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>Old age user</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Health-related difficulties</td>
                  <td colspan="2">17 (55)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Lack of previous experience</td>
                  <td colspan="2">5 (16)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Uncertain with the technology</td>
                  <td colspan="2">5 (16)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Irritation or frustration</td>
                  <td colspan="2">4 (13)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Lack of motivation or interest</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Personal factors</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Fatigue</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Being intimidated</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Lack of digital competence</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Skeptical</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Unwilling to use the technology</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td colspan="5">
                    <bold>Objectification</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>Object at home</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Design</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Placement in the home</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Ergonomics</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>Data protection and security of the eHealth</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Concerns about security or privacy</td>
                  <td colspan="2">4 (13)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Lack of reliability</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td colspan="5">
                    <bold>Incorporation</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>Everyday life</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Unsuitable for everyday life</td>
                  <td colspan="2">3 (10)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Time constraints or power dynamics</td>
                  <td colspan="2">3 (10)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Lack of utility</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Inappropriate technology</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Logistical difficulties</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Not meaningful information</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Not meaningful service</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Technology used only occasionally</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td colspan="5">
                    <bold>Conversion</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>Social interactions</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Need for face-to-face contact</td>
                  <td colspan="2">7 (23)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Lack of support</td>
                  <td colspan="2">3 (10)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Family relationships</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Feeling like an outsider</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Lack of communication</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Lack of patient–professional communication</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Shyness</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>unable to use independently</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>Society and culture</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Older age</td>
                  <td colspan="2">4 (13)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Not culturally relevant</td>
                  <td colspan="2">3 (10)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Living in rural area</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Lower socioeconomic status</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Being female</td>
                  <td colspan="2">1 (3)</td>
                </tr>
              </tbody>
            </table>
          </table-wrap>
          <table-wrap position="float" id="table2">
            <label>Table 2</label>
            <caption>
              <p>Summary of the findings concerning the enablers of learning and use of eHealth technologies among older adults (N=31).</p>
            </caption>
            <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
              <col width="30"/>
              <col width="30"/>
              <col width="700"/>
              <col width="0"/>
              <col width="240"/>
              <thead>
                <tr valign="top">
                  <td colspan="4">Dimension of domestication and enablers</td>
                  <td>Papers, n (%)</td>
                </tr>
              </thead>
              <tbody>
                <tr valign="top">
                  <td colspan="5">
                    <bold>Appropriation</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>eHealth technology</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Usability</td>
                  <td colspan="2">18 (58)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Personalization or flexibility</td>
                  <td colspan="2">13 (42)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Familiarity</td>
                  <td colspan="2">9 (29)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Feedback</td>
                  <td colspan="2">7 (23)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Accessibility</td>
                  <td colspan="2">3 (10)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Automated service</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Novelty effect</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Offers personal challenge</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Positive experiences of others</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>Old age user</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Satisfaction</td>
                  <td colspan="2">14 (15)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Confidence or self-esteem</td>
                  <td colspan="2">4 (13)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Self-efficacy</td>
                  <td colspan="2">4 (13)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Feeling of success</td>
                  <td colspan="2">3 (10)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Open-minded</td>
                  <td colspan="2">3 (10)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Digital competence of the user</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Interest in electronic devices</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>No feeling of privacy loss</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Own choice</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td colspan="5">
                    <bold>Objectification</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>Object at home</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Placement in the home</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Design</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>Data protection and security of the eHealth</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Technology’s security or safety</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>User privacy</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Reliability</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td colspan="5">
                    <bold>Incorporation</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>Everyday life</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Suitable for everyday life</td>
                  <td colspan="2">10 (32)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Service provided educational information</td>
                  <td colspan="2">8 (26)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Active part of user’s own care, self-care</td>
                  <td colspan="2">7 (23)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Playful</td>
                  <td colspan="2">7 (23)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>No logistical barriers</td>
                  <td colspan="2">7 (23)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>No temporal barriers</td>
                  <td colspan="2">6 (19)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Improve quality of daily life</td>
                  <td colspan="2">6 (19)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Useful service</td>
                  <td colspan="2">6 (19)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Increased security</td>
                  <td colspan="2">5 (16)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Systematic use of the technology</td>
                  <td colspan="2">4 (13)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Extends one’s own habitat</td>
                  <td colspan="2">3 (10)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Healthier lifestyle</td>
                  <td colspan="2">3 (10)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Meaningful service</td>
                  <td colspan="2">3 (10)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>No financial barriers</td>
                  <td colspan="2">3 (10)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Brings joy</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Fewer clinical visits</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Technology provides freedom</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Helpful</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Not in a hurry</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td colspan="5">
                    <bold>Conversion</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>Social interactions</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Support practices</td>
                  <td colspan="2">27 (87)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Social connectedness and belonging</td>
                  <td colspan="2">10 (32)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Patient–professional communication</td>
                  <td colspan="2">9 (29)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Visual contact</td>
                  <td colspan="2">4 (13)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Shared experience</td>
                  <td colspan="2">3 (10)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Face-to-face meeting</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Group assignments</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Social comparison</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Feeling less lonely</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Individual attention</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Loneliness</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Relationship with technology</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>Society and culture</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Cost-effectiveness</td>
                  <td colspan="2">8 (26)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Cultural relevance</td>
                  <td colspan="2">4 (13)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Supports independence</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Feeling of being equal</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Being female</td>
                  <td colspan="2">2 (6)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>User feels like an active citizen</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Being considered <italic>cool</italic></td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Educated or employed</td>
                  <td colspan="2">1 (3)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>Older age</td>
                  <td colspan="2">1 (3)</td>
                </tr>
              </tbody>
            </table>
          </table-wrap>
        </sec>
        <sec>
          <title>Appropriation</title>
          <p>Of the 31 articles, 30 (97%) reported barriers and enablers in the appropriation phase of the domestication process; this dimension had more barriers than the others. Older users’ <italic>health-related difficulties</italic> was the most common barrier in the appropriation phase and the whole domestication process (17/31, 55%). For example, difficulties included cognitive impairment or dementia [<xref ref-type="bibr" rid="ref37">37</xref>-<xref ref-type="bibr" rid="ref39">39</xref>] and impaired hearing or vision [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>]. The most common barriers related to the eHealth technologies themselves were <italic>a lack of connectivity</italic> (eg, a lack of access to fast enough internet connections), which was reported in 29% (9/31) of articles [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref43">43</xref>] and other <italic>technical problems</italic>, which were reported in 26% (8/31) of articles [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref45">45</xref>]. <italic>The usability</italic> of eHealth technology, which included ease of use, was the ruling enabler and was reported in 58% (18/31) of studies [<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>]. <italic>Satisfaction</italic> was also seen as a significant enabler in the domestication process and was reported in 45% (14/31) of studies [<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]. In addition, <italic>personalization or flexibility</italic> of eHealth technology was reported as an enabler in 42% (13/31) of studies [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>]. That the technology o<italic>ffered a personal challenge</italic> was reported as an enabler in 3% (1/31) of article [<xref ref-type="bibr" rid="ref37">37</xref>]; the article reported that if the tasks proposed in a mental training system are slightly above users’ capabilities, users’ motivation is increased and training outcomes are improved. That the <italic>technology was unexpected</italic> was reported as a barrier in 3% (1/31) of articles [<xref ref-type="bibr" rid="ref51">51</xref>], and this refers to users feeling they had received a remote monitoring system unexpectedly without a choice and without knowing what the system was.</p>
        </sec>
        <sec>
          <title>Objectification</title>
          <p>Objectification was the least-coded dimension, and there was not a big difference between the different subcategories. The <italic>design</italic> of the eHealth technology and its placement in the home were reported as barriers and enablers. As a barrier, design referred to the look of a computer [<xref ref-type="bibr" rid="ref50">50</xref>] and the weight and size of a remote monitoring system [<xref ref-type="bibr" rid="ref51">51</xref>]. As an enabler, it was connected to the range of soundscapes provided to the users in an interaction radio [<xref ref-type="bibr" rid="ref52">52</xref>]. In 3% (1/31) of articles [<xref ref-type="bibr" rid="ref50">50</xref>], it was found that if a technology is placed <italic>out of the way</italic>, the placement can be a barrier to its use; however, if it is placed where the user spends time, it is used more often. In the Ottenberg et al [<xref ref-type="bibr" rid="ref51">51</xref>] study, in addition to the weight and size of the system, wiring configurations challenged its placement. Furthermore, <italic>ergonomic challenges</italic>, such as typing or using a mouse, were reported as barriers in 3% (1/31) of articles [<xref ref-type="bibr" rid="ref40">40</xref>], and this was in the context of a web-based pain management program designed for older adults with chronic pain. The objectification dimension also included barriers and enablers related to data protection and security. Here, the most common barriers were <italic>concerns about security or privacy</italic> [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>]. The leading enablers were <italic>technology security or safety</italic> [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref51">51</xref>] and <italic>user privacy</italic> [<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref50">50</xref>].</p>
        </sec>
        <sec>
          <title>Incorporation</title>
          <p>Of the 31 articles, 24 (77%) reported barriers and enablers during the incorporation phase. As reported in 32% (10/31) of articles, the most common enabler was that the eHealth technology was <italic>suitable for everyday life</italic> of older adults. For example, this was evident in how users did not actively think they used the technology [<xref ref-type="bibr" rid="ref52">52</xref>], were able to use it in a self-selected environment [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref53">53</xref>], and found that it matched their needs [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]. A total of 2 equally common barriers, each reported in 10% (3/31) of articles, were that the technology was <italic>unsuitable for everyday life</italic> and that there were <italic>time constraints or power dynamics</italic> in using it, which means, for example, that users had scheduling conflicts [<xref ref-type="bibr" rid="ref38">38</xref>], were busy [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref53">53</xref>], or expected faster replies via the technology [<xref ref-type="bibr" rid="ref53">53</xref>]. The reasons the technology was not suitable for users’ daily lives were that the users had to change or constrain their behaviors when using it [<xref ref-type="bibr" rid="ref52">52</xref>], were busy or on holiday [<xref ref-type="bibr" rid="ref53">53</xref>], and had experienced a stressful life event that caused them to disengage with the service [<xref ref-type="bibr" rid="ref56">56</xref>].</p>
        </sec>
        <sec>
          <title>Conversion</title>
          <p>The conversion dimension had more enablers than the other dimensions. The most common enabler in the conversion phase and the entire domestication process was <italic>support practices</italic>, which was reported in 87% (27/31) of articles. The findings are presented in detail in <italic>the Support Practices During Domestication</italic> section below. Regarding social interactions, s<italic>ocial connectedness and belonging</italic> were mentioned as enablers in the learning and use of eHealth technology in 32% (10/31) of studies [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref57">57</xref>]. The common barriers related to social interactions were that older adults had a <italic>need for face-to-face contact</italic> [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref51">51</xref>] and felt a <italic>lack of support</italic> while using the technology [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref58">58</xref>].</p>
          <p>Regarding society and culture, <italic>cost-effectiveness</italic> was the most common enabler in the conversion phase, as reported in 26% (8/31) of articles. However, it was almost never reported from a user’s perspective and was more society driven, providing “huge savings in clinical costs” [<xref ref-type="bibr" rid="ref59">59</xref>], “significant saves in the health budgets” [<xref ref-type="bibr" rid="ref60">60</xref>], and “suggesting a cost reduction for the health care system” [<xref ref-type="bibr" rid="ref46">46</xref>]. In addition, in 13% (4/31) of articles, <italic>cultural relevance</italic> was noted as an enabler, which means, for example, that the users could incorporate their religious or spiritual perspectives into the service [<xref ref-type="bibr" rid="ref48">48</xref>] or that televisions were used as devices, as they were best integrated into the older adults’ lives [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref59">59</xref>].</p>
          <p>In addition, o<italic>lder age</italic> and <italic>being female</italic> were reported as enablers and barriers in different articles. For example, 3% (1/31) of articles [<xref ref-type="bibr" rid="ref60">60</xref>] reported that women needed more assistance using a mobile health app than men, and in 6% (2/31) of articles [<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref67">67</xref>], women were more active eHealth technology users than men. Older age was mainly seen as a barrier in cases where older adults needed more help using the technology [<xref ref-type="bibr" rid="ref60">60</xref>] or used it less than younger people [<xref ref-type="bibr" rid="ref60">60</xref>-<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]. However, in 3% (1/31) of articles [<xref ref-type="bibr" rid="ref60">60</xref>], older patients reported greater improvements in several measures than younger patients. In 3% (1/31) of articles [<xref ref-type="bibr" rid="ref62">62</xref>], it was reported that <italic>a</italic> l<italic>ower social class</italic> reduced the prevalence of eHealth technology use.</p>
        </sec>
      </sec>
      <sec>
        <title>Support Practices During Domestication</title>
        <p>To understand how older adults were supported while domesticating eHealth technologies, the thematic analysis produced 25 subcategories related to their learning to use and the use of technology. The subcategories were clustered into two upper-level categories: social network support (22/31, 71%) and nonsocial support (3/31, 10%). Of the 31 articles, 27 (87%) reported that support was provided to users during the domestication process [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref17">17</xref>].</p>
        <sec>
          <title>Social Network Support</title>
          <p>Social network support was provided in 87% (27/31) of articles. During the learning process at the beginning of domestication, <italic>face-to-face support</italic> was more common than long-distance support. Face-to-face support was provided to users in 45% (14/31) of articles and long-distance support in 13% (4/31) of articles. The most common way to teach older adults was <italic>a training session</italic>, which was used in 42% (13/31) of articles. Training sessions were used to introduce the users to the use of the technology, and it could happen either at users’ homes [<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>] or in a clinical setting [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref47">47</xref>]. The training was usually given by technical staff [<xref ref-type="bibr" rid="ref59">59</xref>], health care professionals [<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref63">63</xref>], or the researcher of the study [<xref ref-type="bibr" rid="ref53">53</xref>]. <italic>Long-distance support</italic> was more common than face-to-face support after initial training. Long-distance support was provided to users in 39% (12/31) of articles and face-to-face support in 10% (3/31) of articles. Long-distance support was mostly provided <italic>via phone</italic>, and it was mainly related to technical issues [<xref ref-type="bibr" rid="ref59">59</xref>] or questions related to the study [<xref ref-type="bibr" rid="ref61">61</xref>], although it also took the form of consultation with a health care professional [<xref ref-type="bibr" rid="ref42">42</xref>] or communication with a peer [<xref ref-type="bibr" rid="ref38">38</xref>]. In some articles, it was not possible to identify whether social network support was face-to-face or long-distance.</p>
          <p>During the domestication process, eHealth technology users distributed their digital competence [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref14">14</xref>] with the following members of social networks: <italic>spouses, grandchildren, other family members and relatives, family caregivers, peers, friends, health care professionals, coaches, researchers, technical staff,</italic> and <italic>proctors</italic>. Social networks expanded as the domestication process went further. Digital competences were most commonly distributed among health care professionals, such as nurses, therapists, and social workers. This was reported in 48% (15/31) of articles [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>]. Second, technical staff was mentioned in 23% (7/31) of studies [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref63">63</xref>].</p>
        </sec>
        <sec>
          <title>Nonsocial Support</title>
          <p>Nonsocial support practices in the learning process were <italic>written instructions</italic> [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref63">63</xref>], <italic>video instructions</italic> [<xref ref-type="bibr" rid="ref53">53</xref>], and <italic>diaries</italic> [<xref ref-type="bibr" rid="ref52">52</xref>]. Users owned their diaries before engaging in the study, and their use to support learning was not planned beforehand. Nonsocial support practices were not defined after users passed the introduction phase; however, in 3% (1/31) of articles, users were encouraged to “access the video at any time during the trial” [<xref ref-type="bibr" rid="ref53">53</xref>]. None of the articles reported the provision of only nonsocial support. Nonsocial support was always connected to social network support.</p>
        </sec>
      </sec>
      <sec>
        <title>Meanings of eHealth in Rural and Remote Areas</title>
        <sec>
          <title>Overview</title>
          <p>The focus of the third research question was on the meanings attached to eHealth technologies for older adults living in rural and remote areas. The terms <italic>rural</italic>, <italic>remote</italic>, and <italic>sparsely populated area</italic> were used to search the databases (<xref ref-type="boxed-text" rid="box1">Textbox 1</xref>) for this literature review. However, in only 55% (17/31) of articles, every participant (12/17, 71%) or part of the participants (5/17, 29%) lived in rural or remote areas. The minimum amount of rural or remote participants per selected article was 13.29%. The thematic analysis produced 17 subcategories of meanings attached to eHealth technologies for older adults living in rural and remote areas. The subcategories were clustered into 2 upper-level categories: needed for rural and remote areas (13/17, 76%) and source of inconvenience and concern (4/17, 24%). The articles defined rural and remote areas as underserved areas with limited access to health care.</p>
        </sec>
        <sec>
          <title>Needed for Rural and Remote Area</title>
          <p>Of the 17 articles, 14 (82%) reported that different eHealth technologies, such as home telehealth monitoring and videoconferencing for consultation, were needed in rural and remote areas. A total of 2 meanings clearly stood out: first, 71% (12/17) of articles [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref56">56</xref>] reported that eHealth technologies <italic>facilitate access to health care services</italic> for older rural adults; second, 65% (11/17) of articles [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref64">64</xref>] reported that there are <italic>no logistical barriers</italic> to health care services when older rural adults use eHealth technology at home. Other, less commonly reported meanings were <italic>no temporal barriers</italic> [<xref ref-type="bibr" rid="ref61">61</xref>], <italic>no financial barriers</italic> [<xref ref-type="bibr" rid="ref48">48</xref>]<italic>, supports relationship with care provider</italic> [<xref ref-type="bibr" rid="ref64">64</xref>], <italic>no physical or physiological stress</italic> [<xref ref-type="bibr" rid="ref39">39</xref>], <italic>ability to support rural caregivers</italic> [<xref ref-type="bibr" rid="ref42">42</xref>], <italic>reduces boundaries of home</italic> [<xref ref-type="bibr" rid="ref50">50</xref>], <italic>reduces feelings of isolation</italic> [<xref ref-type="bibr" rid="ref44">44</xref>], <italic>ensures equal access to health care services</italic> [<xref ref-type="bibr" rid="ref41">41</xref>], <italic>increases feelings of security</italic> [<xref ref-type="bibr" rid="ref44">44</xref>], <italic>no weather-related barriers</italic> [<xref ref-type="bibr" rid="ref39">39</xref>], and <italic>permits religious or spiritual inclusion</italic> [<xref ref-type="bibr" rid="ref48">48</xref>].</p>
        </sec>
        <sec>
          <title>Source of Inconvenience and Concern</title>
          <p>Although eHealth technology was principally seen as needed for rural and remote areas, 24% (4/17) of articles identified sources of inconvenience and concern. Here, the most commonly coded meanings are related to internet connectivity and use. Approximately 18% (3/17) of studies reported that rural areas <italic>lack access to high-speed internet</italic> [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref61">61</xref>]. Approximately 12% (2/17) of studies [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref61">61</xref>] noted <italic>cultural differences regarding internet use</italic> in rural areas compared with urban areas. Older adults in rural areas are still uncomfortable using the internet. Approximately 6% (1/17) of studies [<xref ref-type="bibr" rid="ref45">45</xref>] reported that living in rural areas required <italic>additional equipment</italic>, such as “protectors to protect equipment,” and rural participants had to <italic>learn how to reset</italic> the technology “to decrease the need for providers to make a home visit specific to technical support.” The latter was the only meaning assigned to learning to use eHealth technology in rural areas.</p>
        </sec>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>To advance the understanding of older adults’ (aged ≥60 years) eHealth learning and use during its domestication, a systematic literature review of 31 empirical studies published between 2010 and January 2020 was conducted. The aim was to summarize the literature on the barriers and enablers that older adults encounter when learning to use and using eHealth technology and how they are supported in real home settings. The main targets were rural and remote older adults. The key findings of this review confirmed that social networks supporting older adults are important enablers for learning how to use and using eHealth technology. In addition, this review revealed that health-related difficulties often prevent older adults from domesticating eHealth technologies. Various eHealth technologies have been reported as necessary for older adults in rural and remote areas, although some sources of inconvenience and concern related to internet connectivity and use were found.</p>
        <p>One of the goals of this review was to find out which barriers and enablers are related to learning how to use and using eHealth technologies in the domestication processes among older adults living at home. The findings were divided into 4 dimensions (appropriation, objectification, incorporation, and conversion) of the domestication process [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref17">17</xref>]. The barriers and enablers are in line with previous similar systematic reviews [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref26">26</xref>]. The accessibility of support and training, usability of the technology, and its suitability for daily life were also stressed in the present review. However, for example, concerns regarding the cost or importance of motivation to use eHealth technologies were not key factors in this review. There was a significant difference between the number of reported barriers (n=48) and enablers (n=63), with enablers being more common. This may be because of a desire to highlight the benefits of eHealth technology in a study, even if unintentionally. The appropriation dimension had the most barriers, which suggests that the first phase of domestication is critical. Previous research [<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>] has expressed that access and support for older adults using technology, especially in the early weeks of its domestication, may be the most important factor in successful technology adoption. Overall, the studies focused less on the learning process than on the use of technology.</p>
        <p>In addition, this systematic review asked how older adults living at home are supported during the domestication of eHealth technology. In most cases, older adults distributed their digital competences with their social networks, which supported the domestication of eHealth technology. The social network included <italic>warm experts</italic> who are “nonprofessional persons who help inexperienced users come to terms with digital devices” [<xref ref-type="bibr" rid="ref70">70</xref>], such as family members and peers. The network also included formal personnel, such as health care professionals and technical staff. Previous qualitative research related to eHealth learning and use [<xref ref-type="bibr" rid="ref71">71</xref>] has underlined that there is a need to clarify the role of peer-to-peer support in the domestication of technology. This study revealed that peer-to-peer support has its place in the digital health technology context [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref52">52</xref>] as well as in other settings [<xref ref-type="bibr" rid="ref14">14</xref>]. However, health care professionals were found to be the ones with whom digital competences were most often distributed; therefore, this review argues that digital competences related to eHealth learning and use are not only technical skills but also knowledge and skills related to health care, which is why health care professionals are also needed to support eHealth technology users.</p>
        <p>This review’s final aim was to better understand the meanings attached to eHealth technologies for older adults living in rural and remote areas. Although the literature includes few studies set in rural and remote areas, this review confirms that eHealth technologies are needed in rural and remote areas for several reasons. eHealth technology is seen as solving many problems related to limited access to health care services, such as logistical, temporal, financial, and weather-related barriers. In addition, eHealth technologies can foster a sense of belonging in older rural residents by reducing feelings of isolation and by connecting them with peers or care providers. Previous research has also shown that ICT services can reduce social isolation and promote social connectivity in older adults experiencing physical and cognitive decline or living in remote areas [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref73">73</xref>]. However, the use of eHealth technology in rural and remote areas is hampered by the lack of high-speed internet connections and older adults’ lack of comfort in using ICTs. These issues are targets for future development. The findings of this systematic review confirm that the use and nonuse of eHealth technology are related to its fit in older adults’ technology-related cultural understanding and the context in which people act and live [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref14">14</xref>].</p>
        <p>This review reveals several gaps that suggest directions for future research. First, a stronger focus on older adults’ learning processes is required in research on the domestication of eHealth technology. In the literature search, numerous articles focused only on older adults and the use of eHealth technology from a biomedical [<xref ref-type="bibr" rid="ref74">74</xref>] or technical perspective [<xref ref-type="bibr" rid="ref75">75</xref>]. They were excluded from the review as they did not focus on the user’s point of view. Burholt and Dobbs [<xref ref-type="bibr" rid="ref2">2</xref>] also found that research on rural aging is dominated by a biomedical perspective. Second, as this review confirmed, eHealth technology is needed in rural and remote areas. Therefore, more studies in these settings are required to better understand the processes of domesticating eHealth technology among older rural residents. Third, research efforts in eHealth technology studies in real home settings are limited. Several studies were excluded from this review as they focused on a communal dwelling [<xref ref-type="bibr" rid="ref76">76</xref>] or nursing home [<xref ref-type="bibr" rid="ref77">77</xref>], although the aim of the care policies is aging in place [<xref ref-type="bibr" rid="ref10">10</xref>], which may be because it is easier to reach older adults and conduct research in organized environments. Finally, methodologically, studies on the domestication of technology were mostly qualitative, and mixed methods studies were most common [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref78">78</xref>]. However, the studies reviewed here were mainly quantitative. Therefore, future qualitative studies on this topic should include the voices of older adults. Furthermore, by the time this review is published, new papers relevant to this topic will have also been published. Therefore, new systematic literature reviews should be regularly conducted on the topic of eHealth knowledge and use among older adults living at home in rural and remote areas.</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>This review has several limitations. First, as there was only 1 reviewer involved, this review’s quality and reliability were somewhat weakened. Additional reviewers would have challenged the decisions made by the author. Second, although the selected studies were conducted in 12 countries, Western countries and English-speaking countries dominated, and studies not written in English were excluded. As noted in earlier reviews [<xref ref-type="bibr" rid="ref30">30</xref>], this may create a bias by, for example, basing the findings mainly on reports from Western cultures. Furthermore, despite this review’s intent, not all the studies were set in rural and remote areas, and therefore, its findings cannot be directly adopted in rural and remote contexts, with the exception of those of the third research question. The search included a comprehensive variation of health- and technology-related search terms (<xref ref-type="boxed-text" rid="box1">Textbox 1</xref>). The search terms did not include common abbreviations, such as <italic>eHealth</italic> and <italic>mHealth.</italic> However, these absences did not likely have a significant effect on the results. In addition, health technologies develop rapidly [<xref ref-type="bibr" rid="ref35">35</xref>]; therefore, this review’s start date of 2010 may seem distant. However, a 10-year period is commonly used in qualitative reviews of eHealth technology [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]. As noted by Vuojärvi [<xref ref-type="bibr" rid="ref79">79</xref>], “although technologies change rapidly, people and the ways technologies are used in everyday lives, and particularly in the learning process, do not necessarily do so.”</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>This literature review provides information and practical implications for designers, health care providers, and policy makers. eHealth technology targeted at older adults should be easy to use, and adequate support and training should be provided to users [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref80">80</xref>]. There are plenty of barriers that prevent older adults from ably and independently using eHealth technologies at home. Special attention should be paid to the most common barriers to learning how to use and using eHealth technologies: health-related difficulties, lack of internet connectivity, and other technical problems. We would like to emphasize the importance of considering older adults’ social and cultural practices when designing and implementing eHealth technologies. Social network support and technology integration into everyday life in rural areas contribute to a successful domestication process.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), a 27-item checklist.</p>
        <media xlink:href="jmir_v23i12e23804_app1.pdf" xlink:title="PDF File  (Adobe PDF File), 103 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>An example search string for Scopus (Elsevier).</p>
        <media xlink:href="jmir_v23i12e23804_app2.pdf" xlink:title="PDF File  (Adobe PDF File), 50 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Summary of included articles.</p>
        <media xlink:href="jmir_v23i12e23804_app3.pdf" xlink:title="PDF File  (Adobe PDF File), 147 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">ICT</term>
          <def>
            <p>information and communication technology</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">PRISMA</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This study was part of a larger research project called HARVEST—eHealth and Aging in Rural Areas: Transforming Everyday Life, Digital Competences, and Technology (2018-2021). The project is nationally supported by the Academy of Finland (318835) as part of the international JPI MYBL (Joint Programming Initiative More Years, Better Lives) call. JPI MYBL is supported by the J-AgeII. J-AgeII is funded by Horizon 2020, the EU Framework Program for Research and Innovation, under grant agreement 643850, the JPI MYBL.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Black</surname>
              <given-names>AD</given-names>
            </name>
            <name name-style="western">
              <surname>Car</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Pagliari</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Anandan</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Cresswell</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Bokun</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>McKinstry</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Procter</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Majeed</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Sheikh</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>The impact of eHealth on the quality and safety of health care: a systematic overview</article-title>
          <source>PLoS Med</source>
          <year>2011</year>
          <month>01</month>
          <day>18</day>
          <volume>8</volume>
          <issue>1</issue>
          <fpage>e1000387</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://dx.plos.org/10.1371/journal.pmed.1000387"/>
          </comment>
          <pub-id pub-id-type="doi">10.1371/journal.pmed.1000387</pub-id>
          <pub-id pub-id-type="medline">21267058</pub-id>
          <pub-id pub-id-type="pmcid">PMC3022523</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Burholt</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Dobbs</surname>
              <given-names>C</given-names>
            </name>
          </person-group>
          <article-title>Research on rural ageing: where have we got to and where are we going in Europe?</article-title>
          <source>J Rural Stud</source>
          <year>2012</year>
          <month>10</month>
          <volume>28</volume>
          <issue>4</issue>
          <fpage>432</fpage>
          <lpage>46</lpage>
          <pub-id pub-id-type="doi">10.1016/j.jrurstud.2012.01.009</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kilpeläinen</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Seppänen</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Information technology and everyday life in ageing rural villages</article-title>
          <source>J Rural Stud</source>
          <year>2014</year>
          <month>01</month>
          <volume>33</volume>
          <fpage>1</fpage>
          <lpage>8</lpage>
          <pub-id pub-id-type="doi">10.1016/j.jrurstud.2013.10.005</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Pruchno</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <article-title>Technology and aging: an evolving partnership</article-title>
          <source>Gerontologist</source>
          <year>2019</year>
          <month>01</month>
          <day>09</day>
          <volume>59</volume>
          <issue>1</issue>
          <fpage>1</fpage>
          <lpage>5</lpage>
          <pub-id pub-id-type="doi">10.1093/geront/gny153</pub-id>
          <pub-id pub-id-type="medline">30629258</pub-id>
          <pub-id pub-id-type="pii">5281343</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <nlm-citation citation-type="web">
          <article-title>Official records of World Health Organization, no 2. Summary report on proceedings minutes and final acts of the international health conference health in New York from 19 June to 22 July 1946</article-title>
          <source>United Nations World Health Organization Interim Commission</source>
          <access-date>2021-11-16</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://apps.who.int/iris/bitstream/handle/10665/85573/Official_record2_eng.pdf?sequence=1&#38;isAllowed=y">https://apps.who.int/iris/bitstream/handle/10665/85573/Official_record2_eng.pdf?sequence=1&#38;isAllowed=y</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Eysenbach</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>What is e-health?</article-title>
          <source>J Med Internet Res</source>
          <year>2001</year>
          <volume>3</volume>
          <issue>2</issue>
          <fpage>E20</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2001/2/e20/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.3.2.e20</pub-id>
          <pub-id pub-id-type="medline">11720962</pub-id>
          <pub-id pub-id-type="pmcid">PMC1761894</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Oh</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Rizo</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Enkin</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Jadad</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>What is eHealth (3): a systematic review of published definitions</article-title>
          <source>J Med Internet Res</source>
          <year>2005</year>
          <month>02</month>
          <day>24</day>
          <volume>7</volume>
          <issue>1</issue>
          <fpage>e1</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2005/1/e1/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.7.1.e1</pub-id>
          <pub-id pub-id-type="medline">15829471</pub-id>
          <pub-id pub-id-type="pii">v7e1</pub-id>
          <pub-id pub-id-type="pmcid">PMC1550636</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <nlm-citation citation-type="web">
          <article-title>World population ageing 2019</article-title>
          <source>United Nations</source>
          <year>2019</year>
          <access-date>2021-11-24</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.un.org/en/development/desa/population/publications/pdf/ageing/WorldPopulationAgeing2019-Report.pdf">https://www.un.org/en/development/desa/population/publications/pdf/ageing/WorldPopulationAgeing2019-Report.pdf</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <collab>World Health Organization</collab>
          </person-group>
          <source>Global health and aging</source>
          <year>2011</year>
          <access-date>2021-11-16</access-date>
          <publisher-name>National Institute on Aging, National Institute of Health</publisher-name>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.who.int/ageing/publications/global_health.pdf">https://www.who.int/ageing/publications/global_health.pdf</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kröger</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Bagnato</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <person-group person-group-type="editor">
            <name name-style="western">
              <surname>Martinelli</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Anttonen</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Mätzke</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Care for older people in early twenty-first-century Europe: Dimensions and directions of change</article-title>
          <source>Social Services Disrupted: Changes, Challenges and Policy Implications for Europe in Times of Austerity. New Horizons in Social Policy Series</source>
          <year>2017</year>
          <publisher-loc>Cheltenham, England</publisher-loc>
          <publisher-name>Elgar</publisher-name>
          <fpage>201</fpage>
          <lpage>18</lpage>
        </nlm-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Murgic</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Hébert</surname>
              <given-names>PC</given-names>
            </name>
            <name name-style="western">
              <surname>Sovic</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Pavlekovic</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Paternalism and autonomy: views of patients and providers in a transitional (post-communist) country</article-title>
          <source>BMC Med Ethics</source>
          <year>2015</year>
          <month>09</month>
          <day>29</day>
          <volume>16</volume>
          <issue>1</issue>
          <fpage>65</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcmedethics.biomedcentral.com/articles/10.1186/s12910-015-0059-z"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/s12910-015-0059-z</pub-id>
          <pub-id pub-id-type="medline">26420014</pub-id>
          <pub-id pub-id-type="pii">10.1186/s12910-015-0059-z</pub-id>
          <pub-id pub-id-type="pmcid">PMC4589086</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Vuorikari</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Punie</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Carretero</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>den Brande</surname>
              <given-names>LV</given-names>
            </name>
          </person-group>
          <source>DigComp 2.0: The Digital Competence Framework for Citizens. Update Phase 1: The Conceptual Reference Model</source>
          <year>2016</year>
          <publisher-loc>Luxembourg</publisher-loc>
          <publisher-name>Publication Office of the European Union</publisher-name>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://op.europa.eu/en/publication-detail/-/publication/bc52328b-294e-11e6-b616-01aa75ed71a1"/>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref13">
        <label>13</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lipponen</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <person-group person-group-type="editor">
            <name name-style="western">
              <surname>Lloyd</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Talja</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Information literacy as a situated and distributed activity</article-title>
          <source>Practising Information Literacy: Bringing Theories of Learning, Practice and Information Literacy Together</source>
          <year>2010</year>
          <publisher-loc>Wagga Wagga</publisher-loc>
          <publisher-name>Centre for Information Studies, Charles Sturt University</publisher-name>
          <fpage>51</fpage>
          <lpage>64</lpage>
        </nlm-citation>
      </ref>
      <ref id="ref14">
        <label>14</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Rasi</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Kilpeläinen</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>The digital competences and agency of older people living in rural villages in Finnish Lapland</article-title>
          <source>Seminar net Int J Media Technol Lifelong Learn</source>
          <year>2015</year>
          <month>11</month>
          <day>7</day>
          <volume>11</volume>
          <issue>2</issue>
          <fpage>149</fpage>
          <lpage>60</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://journals.hioa.no/index.php/seminar/article/view/2357"/>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref15">
        <label>15</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Haddon</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>The contribution of domestication research to in-home computing and media consumption</article-title>
          <source>Inf Soc</source>
          <year>2006</year>
          <month>09</month>
          <volume>22</volume>
          <issue>4</issue>
          <fpage>195</fpage>
          <lpage>203</lpage>
          <pub-id pub-id-type="doi">10.1080/01972240600791325</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref16">
        <label>16</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lie</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Sørensen</surname>
              <given-names>KH</given-names>
            </name>
          </person-group>
          <source>Making Technology Our Own? Domesticating Technology Into Everyday Life</source>
          <year>1996</year>
          <publisher-loc>Oslo, Norway</publisher-loc>
          <publisher-name>Scandinavian University Press</publisher-name>
        </nlm-citation>
      </ref>
      <ref id="ref17">
        <label>17</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Silverstone</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Haddon</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <person-group person-group-type="editor">
            <name name-style="western">
              <surname>Mansell</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Silverstone</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <article-title>Design and the domestication of information and communication technologies: technical change and everyday life</article-title>
          <source>Communication by Design: The Politics of Information and Communication Technologies</source>
          <year>1996</year>
          <publisher-loc>Oxford, England, UK</publisher-loc>
          <publisher-name>Oxford University Press</publisher-name>
          <fpage>44</fpage>
          <lpage>74</lpage>
        </nlm-citation>
      </ref>
      <ref id="ref18">
        <label>18</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Hynes</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Richardson</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <person-group person-group-type="editor">
            <name name-style="western">
              <surname>Dwivedi</surname>
              <given-names>YK</given-names>
            </name>
            <name name-style="western">
              <surname>Lal</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Williams</surname>
              <given-names>MD</given-names>
            </name>
            <name name-style="western">
              <surname>Schneberger</surname>
              <given-names>SL</given-names>
            </name>
            <name name-style="western">
              <surname>Wade</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>What use is domestication theory to information systems research?</article-title>
          <source>Handbook of Research on Contemporary Theoretical Models in Information Systems</source>
          <year>2009</year>
          <publisher-loc>Hershey, PA</publisher-loc>
          <publisher-name>IGI Global</publisher-name>
          <fpage>482</fpage>
          <lpage>94</lpage>
        </nlm-citation>
      </ref>
      <ref id="ref19">
        <label>19</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Hynes</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Rommes</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <person-group person-group-type="editor">
            <name name-style="western">
              <surname>Berker</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Hartmann</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Punie</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Ward</surname>
              <given-names>KJ</given-names>
            </name>
          </person-group>
          <article-title>Fitting the internet into our lives: internet courses for disadvantaged users</article-title>
          <source>Domestication of Media and Technologies</source>
          <year>2006</year>
          <publisher-loc>Berkshire, England</publisher-loc>
          <publisher-name>Open University Press</publisher-name>
          <fpage>123</fpage>
          <lpage>44</lpage>
        </nlm-citation>
      </ref>
      <ref id="ref20">
        <label>20</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Scheerder</surname>
              <given-names>AJ</given-names>
            </name>
            <name name-style="western">
              <surname>van Deursen</surname>
              <given-names>AJ</given-names>
            </name>
            <name name-style="western">
              <surname>van Dijk</surname>
              <given-names>JA</given-names>
            </name>
          </person-group>
          <article-title>Internet use in the home: digital inequality from a domestication perspective</article-title>
          <source>New Media Soc</source>
          <year>2019</year>
          <month>05</month>
          <day>02</day>
          <volume>21</volume>
          <issue>10</issue>
          <fpage>2099</fpage>
          <lpage>18</lpage>
          <pub-id pub-id-type="doi">10.1177/1461444819844299</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref21">
        <label>21</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Silverstone</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <person-group person-group-type="editor">
            <name name-style="western">
              <surname>Berker</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Hartmann</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Punie</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Ward</surname>
              <given-names>KJ</given-names>
            </name>
          </person-group>
          <article-title>Domesticating domestication: reflections on the life of a concept</article-title>
          <source>Domestication of Media and Technologies</source>
          <year>2006</year>
          <publisher-loc>Berkshire, England</publisher-loc>
          <publisher-name>Open University Press</publisher-name>
          <fpage>123</fpage>
          <lpage>44</lpage>
        </nlm-citation>
      </ref>
      <ref id="ref22">
        <label>22</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Gubrium</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Holstein</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>Introduction</article-title>
          <source>Aging and Everyday Life</source>
          <year>2000</year>
          <publisher-loc>Oxford, England</publisher-loc>
          <publisher-name>Blackwell Publishers</publisher-name>
        </nlm-citation>
      </ref>
      <ref id="ref23">
        <label>23</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Haddon</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>Domestication analysis, objects of study, and the centrality of technologies in everyday life</article-title>
          <source>Can J Commun</source>
          <year>2011</year>
          <month>08</month>
          <day>04</day>
          <volume>36</volume>
          <issue>2</issue>
          <fpage>311</fpage>
          <lpage>23</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://eprints.lse.ac.uk/62128/"/>
          </comment>
          <pub-id pub-id-type="doi">10.22230/cjc.2011v36n2a2322</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref24">
        <label>24</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Yusif</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Soar</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Hafeez-Baig</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Older people, assistive technologies, and the barriers to adoption: a systematic review</article-title>
          <source>Int J Med Inform</source>
          <year>2016</year>
          <month>10</month>
          <volume>94</volume>
          <fpage>112</fpage>
          <lpage>6</lpage>
          <pub-id pub-id-type="doi">10.1016/j.ijmedinf.2016.07.004</pub-id>
          <pub-id pub-id-type="medline">27573318</pub-id>
          <pub-id pub-id-type="pii">S1386-5056(16)30155-1</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref25">
        <label>25</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Heart</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Kalderon</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>Older adults: are they ready to adopt health-related ICT?</article-title>
          <source>Int J Med Inform</source>
          <year>2013</year>
          <month>11</month>
          <volume>82</volume>
          <issue>11</issue>
          <fpage>e209</fpage>
          <lpage>31</lpage>
          <pub-id pub-id-type="doi">10.1016/j.ijmedinf.2011.03.002</pub-id>
          <pub-id pub-id-type="medline">21481631</pub-id>
          <pub-id pub-id-type="pii">S1386-5056(11)00068-2</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref26">
        <label>26</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kampmeijer</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Pavlova</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Tambor</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Golinowska</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Groot</surname>
              <given-names>W</given-names>
            </name>
          </person-group>
          <article-title>The use of e-health and m-health tools in health promotion and primary prevention among older adults: a systematic literature review</article-title>
          <source>BMC Health Serv Res</source>
          <year>2016</year>
          <month>09</month>
          <day>05</day>
          <volume>16</volume>
          <issue>Suppl 5</issue>
          <fpage>290</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-016-1522-3"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/s12913-016-1522-3</pub-id>
          <pub-id pub-id-type="medline">27608677</pub-id>
          <pub-id pub-id-type="pii">10.1186/s12913-016-1522-3</pub-id>
          <pub-id pub-id-type="pmcid">PMC5016733</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref27">
        <label>27</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Deutsch</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>Erel</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Paz</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Hoffman</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Zuckerman</surname>
              <given-names>O</given-names>
            </name>
          </person-group>
          <article-title>Home robotic devices for older adults: opportunities and concerns</article-title>
          <source>Comput Human Behav</source>
          <year>2019</year>
          <month>09</month>
          <volume>98</volume>
          <fpage>122</fpage>
          <lpage>33</lpage>
          <pub-id pub-id-type="doi">10.1016/j.chb.2019.04.002</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref28">
        <label>28</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Fang</surname>
              <given-names>ML</given-names>
            </name>
            <name name-style="western">
              <surname>Siden</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Korol</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Demestihas</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Sixsmith</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Sixsmith</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>A scoping review exploration of the intended and unintended consequences of eHealth on older people: a health equity impact assessment</article-title>
          <source>Human Technol</source>
          <year>2018</year>
          <month>11</month>
          <day>30</day>
          <fpage>297</fpage>
          <lpage>323</lpage>
          <pub-id pub-id-type="doi">10.17011/ht/urn.201811224835</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref29">
        <label>29</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Spann</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Stewart</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>Barriers and facilitators of older people's mHealth usage: a qualitative review of older people's views</article-title>
          <source>Human Technol</source>
          <year>2018</year>
          <month>11</month>
          <day>30</day>
          <fpage>264</fpage>
          <lpage>96</lpage>
          <pub-id pub-id-type="doi">10.17011/ht/urn.201811224834</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref30">
        <label>30</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Fischer</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Peine</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Östlund</surname>
              <given-names>B</given-names>
            </name>
          </person-group>
          <article-title>The importance of user involvement: a systematic review of involving older users in technology design</article-title>
          <source>Gerontologist</source>
          <year>2020</year>
          <month>09</month>
          <day>15</day>
          <volume>60</volume>
          <issue>7</issue>
          <fpage>e513</fpage>
          <lpage>e523</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/31773145"/>
          </comment>
          <pub-id pub-id-type="doi">10.1093/geront/gnz163</pub-id>
          <pub-id pub-id-type="medline">31773145</pub-id>
          <pub-id pub-id-type="pii">5644100</pub-id>
          <pub-id pub-id-type="pmcid">PMC7491439</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref31">
        <label>31</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Merkel</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Kucharski</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Participatory design in gerontechnology: a systematic literature review</article-title>
          <source>Gerontologist</source>
          <year>2019</year>
          <month>01</month>
          <day>09</day>
          <volume>59</volume>
          <issue>1</issue>
          <fpage>e16</fpage>
          <lpage>25</lpage>
          <pub-id pub-id-type="doi">10.1093/geront/gny034</pub-id>
          <pub-id pub-id-type="medline">29788319</pub-id>
          <pub-id pub-id-type="pii">4999719</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref32">
        <label>32</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Cheng</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Beauchamp</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Elsworth</surname>
              <given-names>GR</given-names>
            </name>
            <name name-style="western">
              <surname>Osborne</surname>
              <given-names>RH</given-names>
            </name>
          </person-group>
          <article-title>Applying the electronic health literacy lens: systematic review of electronic health interventions targeted at socially disadvantaged groups</article-title>
          <source>J Med Internet Res</source>
          <year>2020</year>
          <month>08</month>
          <day>13</day>
          <volume>22</volume>
          <issue>8</issue>
          <fpage>e18476</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2020/8/e18476/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/18476</pub-id>
          <pub-id pub-id-type="medline">32788144</pub-id>
          <pub-id pub-id-type="pii">v22i8e18476</pub-id>
          <pub-id pub-id-type="pmcid">PMC7453328</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref33">
        <label>33</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Liberati</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Altman</surname>
              <given-names>DG</given-names>
            </name>
            <name name-style="western">
              <surname>Tetzlaff</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Mulrow</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Gøtzsche</surname>
              <given-names>PC</given-names>
            </name>
            <name name-style="western">
              <surname>Ioannidis</surname>
              <given-names>JP</given-names>
            </name>
            <name name-style="western">
              <surname>Clarke</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Devereaux</surname>
              <given-names>PJ</given-names>
            </name>
            <name name-style="western">
              <surname>Kleijnen</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Moher</surname>
              <given-names>D</given-names>
            </name>
          </person-group>
          <article-title>The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration</article-title>
          <source>PLoS Med</source>
          <year>2009</year>
          <month>07</month>
          <day>21</day>
          <volume>6</volume>
          <issue>7</issue>
          <fpage>e1000100</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://dx.plos.org/10.1371/journal.pmed.1000100"/>
          </comment>
          <pub-id pub-id-type="doi">10.1371/journal.pmed.1000100</pub-id>
          <pub-id pub-id-type="medline">19621070</pub-id>
          <pub-id pub-id-type="pmcid">PMC2707010</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref34">
        <label>34</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Heyn</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Meeks</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Pruchno</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <article-title>Methodological guidance for a quality review article</article-title>
          <source>Gerontologist</source>
          <year>2019</year>
          <month>03</month>
          <day>14</day>
          <volume>59</volume>
          <issue>2</issue>
          <fpage>197</fpage>
          <lpage>201</lpage>
          <pub-id pub-id-type="doi">10.1093/geront/gny123</pub-id>
          <pub-id pub-id-type="medline">30698698</pub-id>
          <pub-id pub-id-type="pii">5304498</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref35">
        <label>35</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Patrick</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Hekler</surname>
              <given-names>EB</given-names>
            </name>
            <name name-style="western">
              <surname>Estrin</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Mohr</surname>
              <given-names>DC</given-names>
            </name>
            <name name-style="western">
              <surname>Riper</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Crane</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Godino</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Riley</surname>
              <given-names>WT</given-names>
            </name>
          </person-group>
          <article-title>The pace of technologic change: implications for digital health behavior intervention research</article-title>
          <source>Am J Prev Med</source>
          <year>2016</year>
          <month>11</month>
          <volume>51</volume>
          <issue>5</issue>
          <fpage>816</fpage>
          <lpage>24</lpage>
          <pub-id pub-id-type="doi">10.1016/j.amepre.2016.05.001</pub-id>
          <pub-id pub-id-type="medline">27745681</pub-id>
          <pub-id pub-id-type="pii">S0749-3797(16)30138-6</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref36">
        <label>36</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lee</surname>
              <given-names>SB</given-names>
            </name>
            <name name-style="western">
              <surname>Oh</surname>
              <given-names>JH</given-names>
            </name>
            <name name-style="western">
              <surname>Park</surname>
              <given-names>JH</given-names>
            </name>
            <name name-style="western">
              <surname>Choi</surname>
              <given-names>SP</given-names>
            </name>
            <name name-style="western">
              <surname>Wee</surname>
              <given-names>JH</given-names>
            </name>
          </person-group>
          <article-title>Differences in youngest-old, middle-old, and oldest-old patients who visit the emergency department</article-title>
          <source>Clin Exp Emerg Med</source>
          <year>2018</year>
          <month>12</month>
          <volume>5</volume>
          <issue>4</issue>
          <fpage>249</fpage>
          <lpage>55</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.15441/ceem.17.261"/>
          </comment>
          <pub-id pub-id-type="doi">10.15441/ceem.17.261</pub-id>
          <pub-id pub-id-type="medline">30571903</pub-id>
          <pub-id pub-id-type="pii">ceem.17.261</pub-id>
          <pub-id pub-id-type="pmcid">PMC6301865</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref37">
        <label>37</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Boquete</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Rodríguez-Ascariz</surname>
              <given-names>JM</given-names>
            </name>
            <name name-style="western">
              <surname>Amo-Usanos</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Martínez-Arribas</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Amo-Usanos</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Otón</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>User-friendly cognitive training for the elderly: a technical report</article-title>
          <source>Telemed J E Health</source>
          <year>2011</year>
          <volume>17</volume>
          <issue>6</issue>
          <fpage>456</fpage>
          <lpage>60</lpage>
          <pub-id pub-id-type="doi">10.1089/tmj.2010.0149</pub-id>
          <pub-id pub-id-type="medline">21612520</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref38">
        <label>38</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Colón-Semenza</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Latham</surname>
              <given-names>NK</given-names>
            </name>
            <name name-style="western">
              <surname>Quintiliani</surname>
              <given-names>LM</given-names>
            </name>
            <name name-style="western">
              <surname>Ellis</surname>
              <given-names>TD</given-names>
            </name>
          </person-group>
          <article-title>Peer coaching through mHealth targeting physical activity in people with parkinson disease: feasibility study</article-title>
          <source>JMIR Mhealth Uhealth</source>
          <year>2018</year>
          <month>02</month>
          <day>15</day>
          <volume>6</volume>
          <issue>2</issue>
          <fpage>e42</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://mhealth.jmir.org/2018/2/e42/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/mhealth.8074</pub-id>
          <pub-id pub-id-type="medline">29449201</pub-id>
          <pub-id pub-id-type="pii">v6i2e42</pub-id>
          <pub-id pub-id-type="pmcid">PMC5832905</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref39">
        <label>39</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Read Paul</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Salmon</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Sinnarajah</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Spice</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <article-title>Web-based videoconferencing for rural palliative care consultation with elderly patients at home</article-title>
          <source>Support Care Cancer</source>
          <year>2019</year>
          <month>09</month>
          <volume>27</volume>
          <issue>9</issue>
          <fpage>3321</fpage>
          <lpage>30</lpage>
          <pub-id pub-id-type="doi">10.1007/s00520-018-4580-8</pub-id>
          <pub-id pub-id-type="medline">30613908</pub-id>
          <pub-id pub-id-type="pii">10.1007/s00520-018-4580-8</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref40">
        <label>40</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Philip</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Roberts</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Currie</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Mort</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>technology for older adults: maximising personal and social interaction: exploring opportunities for eHealth to support the older rural population with chronic pain</article-title>
          <source>Scott Geogr J</source>
          <year>2015</year>
          <month>01</month>
          <day>15</day>
          <volume>131</volume>
          <issue>3-4</issue>
          <fpage>181</fpage>
          <lpage>93</lpage>
          <pub-id pub-id-type="doi">10.1080/14702541.2014.978806</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref41">
        <label>41</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Vaskinn</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Wilsgård</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>Holm</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Wootton</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Elvevåg</surname>
              <given-names>B</given-names>
            </name>
          </person-group>
          <article-title>A feasibility study of a telephone-based screening service for mild cognitive impairment and its uptake by elderly people</article-title>
          <source>J Telemed Telecare</source>
          <year>2013</year>
          <month>01</month>
          <volume>19</volume>
          <issue>1</issue>
          <fpage>5</fpage>
          <lpage>10</lpage>
          <pub-id pub-id-type="doi">10.1177/1357633X12473904</pub-id>
          <pub-id pub-id-type="medline">23390214</pub-id>
          <pub-id pub-id-type="pii">1357633X12473904</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref42">
        <label>42</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Hicken</surname>
              <given-names>BL</given-names>
            </name>
            <name name-style="western">
              <surname>Daniel</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Luptak</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Grant</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Kilian</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Rupper</surname>
              <given-names>RW</given-names>
            </name>
          </person-group>
          <article-title>Supporting Caregivers of Rural Veterans Electronically (SCORE)</article-title>
          <source>J Rural Health</source>
          <year>2017</year>
          <month>06</month>
          <volume>33</volume>
          <issue>3</issue>
          <fpage>305</fpage>
          <lpage>13</lpage>
          <pub-id pub-id-type="doi">10.1111/jrh.12195</pub-id>
          <pub-id pub-id-type="medline">27437642</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref43">
        <label>43</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Pavic</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Klaas</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Theile</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Kraft</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Tröster</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Blum</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Guckenberger</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Mobile health technologies for continuous monitoring of cancer patients in palliative care aiming to predict health status deterioration: a feasibility study</article-title>
          <source>J Palliat Med</source>
          <year>2020</year>
          <month>05</month>
          <volume>23</volume>
          <issue>5</issue>
          <fpage>678</fpage>
          <lpage>85</lpage>
          <pub-id pub-id-type="doi">10.1089/jpm.2019.0342</pub-id>
          <pub-id pub-id-type="medline">31873052</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref44">
        <label>44</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Blusi</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Asplund</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Jong</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Older family carers in rural areas: experiences from using caregiver support services based on Information and Communication Technology (ICT)</article-title>
          <source>Eur J Ageing</source>
          <year>2013</year>
          <month>09</month>
          <volume>10</volume>
          <issue>3</issue>
          <fpage>191</fpage>
          <lpage>9</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/28804294"/>
          </comment>
          <pub-id pub-id-type="doi">10.1007/s10433-013-0260-1</pub-id>
          <pub-id pub-id-type="medline">28804294</pub-id>
          <pub-id pub-id-type="pii">260</pub-id>
          <pub-id pub-id-type="pmcid">PMC5549122</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref45">
        <label>45</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Sorocco</surname>
              <given-names>KH</given-names>
            </name>
            <name name-style="western">
              <surname>Bratkovich</surname>
              <given-names>KL</given-names>
            </name>
            <name name-style="western">
              <surname>Wingo</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Qureshi</surname>
              <given-names>SM</given-names>
            </name>
            <name name-style="western">
              <surname>Mason</surname>
              <given-names>PJ</given-names>
            </name>
          </person-group>
          <article-title>Integrating care coordination home telehealth and home based primary care in rural Oklahoma: a pilot study</article-title>
          <source>Psychol Serv</source>
          <year>2013</year>
          <month>08</month>
          <volume>10</volume>
          <issue>3</issue>
          <fpage>350</fpage>
          <lpage>2</lpage>
          <pub-id pub-id-type="doi">10.1037/a0032785</pub-id>
          <pub-id pub-id-type="medline">23937085</pub-id>
          <pub-id pub-id-type="pii">2013-28609-003</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref46">
        <label>46</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Pigini</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Bovi</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Panzarino</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Gower</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Ferratini</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Andreoni</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Sassi</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Rivolta</surname>
              <given-names>MW</given-names>
            </name>
            <name name-style="western">
              <surname>Ferrarin</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Pilot test of a new personal health system integrating environmental and wearable sensors for telemonitoring and care of elderly people at home (SMARTA project)</article-title>
          <source>Gerontology</source>
          <year>2017</year>
          <volume>63</volume>
          <issue>3</issue>
          <fpage>281</fpage>
          <lpage>6</lpage>
          <pub-id pub-id-type="doi">10.1159/000455168</pub-id>
          <pub-id pub-id-type="medline">28099965</pub-id>
          <pub-id pub-id-type="pii">000455168</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref47">
        <label>47</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Williams</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Pennathur</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Bossen</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Gloeckner</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Adapting telemonitoring technology use for older adults: a pilot study</article-title>
          <source>Res Gerontol Nurs</source>
          <year>2016</year>
          <volume>9</volume>
          <issue>1</issue>
          <fpage>17</fpage>
          <lpage>23</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/26020575"/>
          </comment>
          <pub-id pub-id-type="doi">10.3928/19404921-20150522-01</pub-id>
          <pub-id pub-id-type="medline">26020575</pub-id>
          <pub-id pub-id-type="pmcid">PMC4839531</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref48">
        <label>48</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Barrera</surname>
              <given-names>TL</given-names>
            </name>
            <name name-style="western">
              <surname>Cummings</surname>
              <given-names>JP</given-names>
            </name>
            <name name-style="western">
              <surname>Armento</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Cully</surname>
              <given-names>JA</given-names>
            </name>
            <name name-style="western">
              <surname>Bush Amspoker</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Wilson</surname>
              <given-names>NL</given-names>
            </name>
            <name name-style="western">
              <surname>Mallen</surname>
              <given-names>MJ</given-names>
            </name>
            <name name-style="western">
              <surname>Shrestha</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Kunik</surname>
              <given-names>ME</given-names>
            </name>
            <name name-style="western">
              <surname>Stanley</surname>
              <given-names>MA</given-names>
            </name>
          </person-group>
          <article-title>Telephone-delivered cognitive-behavioral therapy for older, rural veterans with depression and anxiety in home-based primary care</article-title>
          <source>Clin Gerontol</source>
          <year>2017</year>
          <volume>40</volume>
          <issue>2</issue>
          <fpage>114</fpage>
          <lpage>23</lpage>
          <pub-id pub-id-type="doi">10.1080/07317115.2016.1254133</pub-id>
          <pub-id pub-id-type="medline">28452676</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref49">
        <label>49</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Luptak</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Dailey</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Juretic</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Rupper</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Hill</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Hicken</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Bair</surname>
              <given-names>B</given-names>
            </name>
          </person-group>
          <article-title>The Care Coordination Home Telehealth (CCHT) rural demonstration project: a symptom-based approach for serving older veterans in remote geographical settings</article-title>
          <source>Rural Remote Health</source>
          <year>2010</year>
          <volume>10</volume>
          <issue>2</issue>
          <fpage>1375</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.rrh.org.au/articles/subviewnew.asp?ArticleID=1375"/>
          </comment>
          <pub-id pub-id-type="medline">20518592</pub-id>
          <pub-id pub-id-type="pii">1375</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref50">
        <label>50</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Blusi</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Kristiansen</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Jong</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Exploring the influence of internet-based caregiver support on experiences of isolation for older spouse caregivers in rural areas: a qualitative interview study</article-title>
          <source>Int J Older People Nurs</source>
          <year>2015</year>
          <month>09</month>
          <volume>10</volume>
          <issue>3</issue>
          <fpage>211</fpage>
          <lpage>20</lpage>
          <pub-id pub-id-type="doi">10.1111/opn.12074</pub-id>
          <pub-id pub-id-type="medline">25425070</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref51">
        <label>51</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ottenberg</surname>
              <given-names>AL</given-names>
            </name>
            <name name-style="western">
              <surname>Swetz</surname>
              <given-names>KM</given-names>
            </name>
            <name name-style="western">
              <surname>Mueller</surname>
              <given-names>LA</given-names>
            </name>
            <name name-style="western">
              <surname>Gerhardson</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Mueller</surname>
              <given-names>PS</given-names>
            </name>
          </person-group>
          <article-title>"We as Human Beings Get Farther and Farther Apart": the experiences of patients with remote monitoring systems</article-title>
          <source>Heart Lung</source>
          <year>2013</year>
          <volume>42</volume>
          <issue>5</issue>
          <fpage>313</fpage>
          <lpage>9</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/23582212"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.hrtlng.2013.03.002</pub-id>
          <pub-id pub-id-type="medline">23582212</pub-id>
          <pub-id pub-id-type="pii">S0147-9563(13)00076-9</pub-id>
          <pub-id pub-id-type="pmcid">PMC3878022</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref52">
        <label>52</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Baharin</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Viller</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Rintel</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>SonicAIR: supporting independent living with reciprocal ambient audio awareness</article-title>
          <source>ACM Trans Comput Hum Interact</source>
          <year>2015</year>
          <month>07</month>
          <day>09</day>
          <volume>22</volume>
          <issue>4</issue>
          <fpage>1</fpage>
          <lpage>23</lpage>
          <pub-id pub-id-type="doi">10.1145/2754165</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref53">
        <label>53</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Garattini</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Wherton</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Prendergast</surname>
              <given-names>D</given-names>
            </name>
          </person-group>
          <article-title>Linking the lonely: an exploration of a communication technology designed to support social interaction among older adults</article-title>
          <source>Univ Access Inf Soc</source>
          <year>2011</year>
          <month>6</month>
          <day>7</day>
          <volume>11</volume>
          <issue>2</issue>
          <fpage>211</fpage>
          <lpage>22</lpage>
          <pub-id pub-id-type="doi">10.1007/s10209-011-0235-y</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref54">
        <label>54</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Sadek</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>Mohktari</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Nonintrusive remote monitoring of sleep in home-based situation</article-title>
          <source>J Med Syst</source>
          <year>2018</year>
          <month>03</month>
          <day>01</day>
          <volume>42</volume>
          <issue>4</issue>
          <fpage>64</fpage>
          <pub-id pub-id-type="doi">10.1007/s10916-018-0917-6</pub-id>
          <pub-id pub-id-type="medline">29497864</pub-id>
          <pub-id pub-id-type="pii">10.1007/s10916-018-0917-6</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref55">
        <label>55</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Holz</surname>
              <given-names>EM</given-names>
            </name>
            <name name-style="western">
              <surname>Botrel</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Kaufmann</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Kübler</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Long-term independent brain-computer interface home use improves quality of life of a patient in the locked-in state: a case study</article-title>
          <source>Arch Phys Med Rehabil</source>
          <year>2015</year>
          <month>03</month>
          <volume>96</volume>
          <issue>3 Suppl</issue>
          <fpage>S16</fpage>
          <lpage>26</lpage>
          <pub-id pub-id-type="doi">10.1016/j.apmr.2014.03.035</pub-id>
          <pub-id pub-id-type="medline">25721543</pub-id>
          <pub-id pub-id-type="pii">S0003-9993(14)00365-7</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref56">
        <label>56</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Naik</surname>
              <given-names>AD</given-names>
            </name>
            <name name-style="western">
              <surname>White</surname>
              <given-names>CD</given-names>
            </name>
            <name name-style="western">
              <surname>Robertson</surname>
              <given-names>SM</given-names>
            </name>
            <name name-style="western">
              <surname>Armento</surname>
              <given-names>ME</given-names>
            </name>
            <name name-style="western">
              <surname>Lawrence</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Stelljes</surname>
              <given-names>LA</given-names>
            </name>
            <name name-style="western">
              <surname>Cully</surname>
              <given-names>JA</given-names>
            </name>
          </person-group>
          <article-title>Behavioral health coaching for rural-living older adults with diabetes and depression: an open pilot of the HOPE study</article-title>
          <source>BMC Geriatr</source>
          <year>2012</year>
          <month>07</month>
          <day>24</day>
          <volume>12</volume>
          <fpage>37</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcgeriatr.biomedcentral.com/articles/10.1186/1471-2318-12-37"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/1471-2318-12-37</pub-id>
          <pub-id pub-id-type="medline">22828177</pub-id>
          <pub-id pub-id-type="pii">1471-2318-12-37</pub-id>
          <pub-id pub-id-type="pmcid">PMC3542105</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref57">
        <label>57</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Far</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>Ferron</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Iberra</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Baez</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Tranquillini</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Casati</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Doppio</surname>
              <given-names>N</given-names>
            </name>
          </person-group>
          <article-title>The interplay of physical and social wellbeing in older adults: investigating the relationship between physical and social interaction with virtual social environments</article-title>
          <source>PeerJ Comput Sci</source>
          <year>2015</year>
          <month>11</month>
          <day>25</day>
          <volume>1</volume>
          <fpage>e30</fpage>
          <pub-id pub-id-type="doi">10.7717/peerj-cs.30</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref58">
        <label>58</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Piau</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Crissey</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Brechemier</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Balardy</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Nourhashemi</surname>
              <given-names>F</given-names>
            </name>
          </person-group>
          <article-title>A smartphone Chatbot application to optimize monitoring of older patients with cancer</article-title>
          <source>Int J Med Inform</source>
          <year>2019</year>
          <month>08</month>
          <volume>128</volume>
          <fpage>18</fpage>
          <lpage>23</lpage>
          <pub-id pub-id-type="doi">10.1016/j.ijmedinf.2019.05.013</pub-id>
          <pub-id pub-id-type="medline">31160007</pub-id>
          <pub-id pub-id-type="pii">S1386-5056(19)30210-2</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref59">
        <label>59</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Costa</surname>
              <given-names>CR</given-names>
            </name>
            <name name-style="western">
              <surname>Iglesias</surname>
              <given-names>MJ</given-names>
            </name>
            <name name-style="western">
              <surname>Rifón</surname>
              <given-names>LE</given-names>
            </name>
            <name name-style="western">
              <surname>Carballa</surname>
              <given-names>MG</given-names>
            </name>
            <name name-style="western">
              <surname>Rodríguez</surname>
              <given-names>SV</given-names>
            </name>
          </person-group>
          <article-title>The acceptability of TV-based game platforms as an instrument to support the cognitive evaluation of senior adults at home</article-title>
          <source>PeerJ</source>
          <year>2017</year>
          <volume>5</volume>
          <fpage>e2845</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.7717/peerj.2845"/>
          </comment>
          <pub-id pub-id-type="doi">10.7717/peerj.2845</pub-id>
          <pub-id pub-id-type="medline">28070464</pub-id>
          <pub-id pub-id-type="pii">2845</pub-id>
          <pub-id pub-id-type="pmcid">PMC5214704</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref60">
        <label>60</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>de Garibay</surname>
              <given-names>VG</given-names>
            </name>
            <name name-style="western">
              <surname>Fernández</surname>
              <given-names>MA</given-names>
            </name>
            <name name-style="western">
              <surname>de la Torre-Díez</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>López-Coronado</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Utility of a mHealth app for self-management and education of cardiac diseases in Spanish urban and rural areas</article-title>
          <source>J Med Syst</source>
          <year>2016</year>
          <month>08</month>
          <volume>40</volume>
          <issue>8</issue>
          <fpage>186</fpage>
          <pub-id pub-id-type="doi">10.1007/s10916-016-0531-4</pub-id>
          <pub-id pub-id-type="medline">27329050</pub-id>
          <pub-id pub-id-type="pii">10.1007/s10916-016-0531-4</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref61">
        <label>61</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Parker</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Rajapakshe</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Moldovan</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Araujo</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Crook</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>An internet-based means of monitoring quality of life in post-prostate radiation treatment: a prospective cohort study</article-title>
          <source>JMIR Res Protoc</source>
          <year>2015</year>
          <month>09</month>
          <day>28</day>
          <volume>4</volume>
          <issue>3</issue>
          <fpage>e115</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.researchprotocols.org/2015/3/e115/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/resprot.3974</pub-id>
          <pub-id pub-id-type="medline">26416584</pub-id>
          <pub-id pub-id-type="pii">v4i3e115</pub-id>
          <pub-id pub-id-type="pmcid">PMC4704929</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref62">
        <label>62</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Strain</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Wijndaele</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Brage</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Physical activity surveillance through smartphone apps and wearable trackers: examining the UK potential for nationally representative sampling</article-title>
          <source>JMIR Mhealth Uhealth</source>
          <year>2019</year>
          <month>01</month>
          <day>29</day>
          <volume>7</volume>
          <issue>1</issue>
          <fpage>e11898</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://mhealth.jmir.org/2019/1/e11898/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/11898</pub-id>
          <pub-id pub-id-type="medline">30694198</pub-id>
          <pub-id pub-id-type="pii">v7i1e11898</pub-id>
          <pub-id pub-id-type="pmcid">PMC6371078</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref63">
        <label>63</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Evangelista</surname>
              <given-names>LS</given-names>
            </name>
            <name name-style="western">
              <surname>Lee</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Moore</surname>
              <given-names>AA</given-names>
            </name>
            <name name-style="western">
              <surname>Motie</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Ghasemzadeh</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Sarrafzadeh</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Mangione</surname>
              <given-names>CM</given-names>
            </name>
          </person-group>
          <article-title>Examining the effects of remote monitoring systems on activation, self-care, and quality of life in older patients with chronic heart failure</article-title>
          <source>J Cardiovasc Nurs</source>
          <year>2015</year>
          <volume>30</volume>
          <issue>1</issue>
          <fpage>51</fpage>
          <lpage>7</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/24365871"/>
          </comment>
          <pub-id pub-id-type="doi">10.1097/JCN.0000000000000110</pub-id>
          <pub-id pub-id-type="medline">24365871</pub-id>
          <pub-id pub-id-type="pmcid">PMC4447139</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref64">
        <label>64</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>West</surname>
              <given-names>SP</given-names>
            </name>
            <name name-style="western">
              <surname>Lagua</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Trief</surname>
              <given-names>PM</given-names>
            </name>
            <name name-style="western">
              <surname>Izquierdo</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Weinstock</surname>
              <given-names>RS</given-names>
            </name>
          </person-group>
          <article-title>Goal setting using telemedicine in rural underserved older adults with diabetes: experiences from the informatics for diabetes education and telemedicine project</article-title>
          <source>Telemed J E Health</source>
          <year>2010</year>
          <month>05</month>
          <volume>16</volume>
          <issue>4</issue>
          <fpage>405</fpage>
          <lpage>16</lpage>
          <pub-id pub-id-type="doi">10.1089/tmj.2009.0136</pub-id>
          <pub-id pub-id-type="medline">20507198</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref65">
        <label>65</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Bock</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Demiris</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Choi</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Le</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Thompson</surname>
              <given-names>HJ</given-names>
            </name>
            <name name-style="western">
              <surname>Samuel</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Huang</surname>
              <given-names>D</given-names>
            </name>
          </person-group>
          <article-title>Engaging older adults in the visualization of sensor data facilitated by an open platform for connected devices</article-title>
          <source>Technol Health Care</source>
          <year>2016</year>
          <month>03</month>
          <day>11</day>
          <volume>24</volume>
          <issue>4</issue>
          <fpage>541</fpage>
          <lpage>50</lpage>
          <pub-id pub-id-type="doi">10.3233/THC-161150</pub-id>
          <pub-id pub-id-type="medline">27002473</pub-id>
          <pub-id pub-id-type="pii">THC1150</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref66">
        <label>66</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Wakefield</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Drwal</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Scherubel</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Klobucar</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Johnson</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Kaboli</surname>
              <given-names>P</given-names>
            </name>
          </person-group>
          <article-title>Feasibility and effectiveness of remote, telephone-based delivery of cardiac rehabilitation</article-title>
          <source>Telemed J E Health</source>
          <year>2014</year>
          <month>01</month>
          <volume>20</volume>
          <issue>1</issue>
          <fpage>32</fpage>
          <lpage>8</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/24161003"/>
          </comment>
          <pub-id pub-id-type="doi">10.1089/tmj.2013.0079</pub-id>
          <pub-id pub-id-type="medline">24161003</pub-id>
          <pub-id pub-id-type="pmcid">PMC3880057</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref67">
        <label>67</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Saleh</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Farah</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>El Arnaout</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Dimassi</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>El Morr</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Muntaner</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Ammar</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Hamadeh</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Alameddine</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>mHealth use for non-communicable diseases care in primary health: patients' perspective from rural settings and refugee camps</article-title>
          <source>J Public Health (Oxf)</source>
          <year>2018</year>
          <month>12</month>
          <day>01</day>
          <volume>40</volume>
          <issue>suppl_2</issue>
          <fpage>ii52</fpage>
          <lpage>63</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/30307516"/>
          </comment>
          <pub-id pub-id-type="doi">10.1093/pubmed/fdy172</pub-id>
          <pub-id pub-id-type="medline">30307516</pub-id>
          <pub-id pub-id-type="pii">5126971</pub-id>
          <pub-id pub-id-type="pmcid">PMC6294037</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref68">
        <label>68</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kamimura</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Ishiwata</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Inoue</surname>
              <given-names>T</given-names>
            </name>
          </person-group>
          <article-title>Medication reminder device for the elderly patients with mild cognitive impairment</article-title>
          <source>Am J Alzheimers Dis Other Demen</source>
          <year>2012</year>
          <month>06</month>
          <volume>27</volume>
          <issue>4</issue>
          <fpage>238</fpage>
          <lpage>42</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://journals.sagepub.com/doi/10.1177/1533317512450066?url_ver=Z39.88-2003&#38;rfr_id=ori:rid:crossref.org&#38;rfr_dat=cr_pub%3dpubmed"/>
          </comment>
          <pub-id pub-id-type="doi">10.1177/1533317512450066</pub-id>
          <pub-id pub-id-type="medline">22739031</pub-id>
          <pub-id pub-id-type="pii">27/4/238</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref69">
        <label>69</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Mitzner</surname>
              <given-names>TL</given-names>
            </name>
            <name name-style="western">
              <surname>Savla</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Boot</surname>
              <given-names>WR</given-names>
            </name>
            <name name-style="western">
              <surname>Sharit</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Charness</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Czaja</surname>
              <given-names>SJ</given-names>
            </name>
            <name name-style="western">
              <surname>Rogers</surname>
              <given-names>WA</given-names>
            </name>
          </person-group>
          <article-title>Technology adoption by older adults: findings from the PRISM trial</article-title>
          <source>Gerontologist</source>
          <year>2019</year>
          <month>01</month>
          <day>09</day>
          <volume>59</volume>
          <issue>1</issue>
          <fpage>34</fpage>
          <lpage>44</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/30265294"/>
          </comment>
          <pub-id pub-id-type="doi">10.1093/geront/gny113</pub-id>
          <pub-id pub-id-type="medline">30265294</pub-id>
          <pub-id pub-id-type="pii">5108474</pub-id>
          <pub-id pub-id-type="pmcid">PMC6326254</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref70">
        <label>70</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Olsson</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Viscovi</surname>
              <given-names>D</given-names>
            </name>
          </person-group>
          <article-title>Warm experts for elderly users: who are they and what do they do?</article-title>
          <source>Human Technol</source>
          <year>2018</year>
          <month>11</month>
          <day>30</day>
          <volume>14</volume>
          <issue>3</issue>
          <fpage>324</fpage>
          <lpage>42</lpage>
          <pub-id pub-id-type="doi">10.17011/ht/urn.201811224836</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref71">
        <label>71</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Airola</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Rasi</surname>
              <given-names>P</given-names>
            </name>
          </person-group>
          <article-title>Domestication of a robotic medication-dispensing service among older people in Finnish Lapland</article-title>
          <source>Human Technology</source>
          <year>2020</year>
          <volume>16</volume>
          <issue>2</issue>
          <fpage>117</fpage>
          <lpage>38</lpage>
          <pub-id pub-id-type="doi">10.17011/ht/urn.202008245639</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref72">
        <label>72</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Hasan</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Linger</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>Enhancing the wellbeing of the elderly: social use of digital technologies in aged care</article-title>
          <source>Educ Gerontol</source>
          <year>2016</year>
          <month>06</month>
          <day>28</day>
          <volume>42</volume>
          <issue>11</issue>
          <fpage>749</fpage>
          <lpage>57</lpage>
          <pub-id pub-id-type="doi">10.1080/03601277.2016.1205425</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref73">
        <label>73</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Tsai</surname>
              <given-names>H-Y</given-names>
            </name>
            <name name-style="western">
              <surname>Shillair</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Cotten</surname>
              <given-names>SR</given-names>
            </name>
            <name name-style="western">
              <surname>Winstead</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Yost</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>Getting grandma online: are tablets the answer for increasing digital inclusion for older adults in the U.S.?</article-title>
          <source>Educ Gerontol</source>
          <year>2015</year>
          <volume>41</volume>
          <issue>10</issue>
          <fpage>695</fpage>
          <lpage>709</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/26877583"/>
          </comment>
          <pub-id pub-id-type="doi">10.1080/03601277.2015.1048165</pub-id>
          <pub-id pub-id-type="medline">26877583</pub-id>
          <pub-id pub-id-type="pmcid">PMC4748942</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref74">
        <label>74</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Brenes</surname>
              <given-names>GA</given-names>
            </name>
            <name name-style="western">
              <surname>Danhauer</surname>
              <given-names>SC</given-names>
            </name>
            <name name-style="western">
              <surname>Lyles</surname>
              <given-names>MF</given-names>
            </name>
            <name name-style="western">
              <surname>Hogan</surname>
              <given-names>PE</given-names>
            </name>
            <name name-style="western">
              <surname>Miller</surname>
              <given-names>ME</given-names>
            </name>
          </person-group>
          <article-title>Telephone-delivered cognitive behavioral therapy and telephone-delivered nondirective supportive therapy for rural older adults with generalized anxiety disorder: a randomized clinical trial</article-title>
          <source>JAMA Psychiatry</source>
          <year>2015</year>
          <month>10</month>
          <volume>72</volume>
          <issue>10</issue>
          <fpage>1012</fpage>
          <lpage>20</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/26244854"/>
          </comment>
          <pub-id pub-id-type="doi">10.1001/jamapsychiatry.2015.1154</pub-id>
          <pub-id pub-id-type="medline">26244854</pub-id>
          <pub-id pub-id-type="pii">2423199</pub-id>
          <pub-id pub-id-type="pmcid">PMC4939613</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref75">
        <label>75</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Do</surname>
              <given-names>HM</given-names>
            </name>
            <name name-style="western">
              <surname>Pham</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Sheng</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Yang</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Liu</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>RiSH: a robot-integrated smart home for elderly care</article-title>
          <source>Rob Auton Syst</source>
          <year>2018</year>
          <month>03</month>
          <volume>101</volume>
          <fpage>74</fpage>
          <lpage>92</lpage>
          <pub-id pub-id-type="doi">10.1016/j.robot.2017.12.008</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref76">
        <label>76</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Son</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>A pilot study to test the feasibility of a home mobility monitoring system in community-dwelling older adults</article-title>
          <source>Int J Environ Res Public Health</source>
          <year>2019</year>
          <month>04</month>
          <day>29</day>
          <volume>16</volume>
          <issue>9</issue>
          <fpage>1512</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.mdpi.com/resolver?pii=ijerph16091512"/>
          </comment>
          <pub-id pub-id-type="doi">10.3390/ijerph16091512</pub-id>
          <pub-id pub-id-type="medline">31035678</pub-id>
          <pub-id pub-id-type="pii">ijerph16091512</pub-id>
          <pub-id pub-id-type="pmcid">PMC6539780</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref77">
        <label>77</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Fossum</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Alexander</surname>
              <given-names>GL</given-names>
            </name>
            <name name-style="western">
              <surname>Ehnfors</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Ehrenberg</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Effects of a computerized decision support system on pressure ulcers and malnutrition in nursing homes for the elderly</article-title>
          <source>Int J Med Inform</source>
          <year>2011</year>
          <month>09</month>
          <volume>80</volume>
          <issue>9</issue>
          <fpage>607</fpage>
          <lpage>17</lpage>
          <pub-id pub-id-type="doi">10.1016/j.ijmedinf.2011.06.009</pub-id>
          <pub-id pub-id-type="medline">21783409</pub-id>
          <pub-id pub-id-type="pii">S1386-5056(11)00131-6</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref78">
        <label>78</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Haddon</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>Roger Silverstone’s legacies: domestication</article-title>
          <source>New Media Soc</source>
          <year>2016</year>
          <month>06</month>
          <day>30</day>
          <volume>9</volume>
          <issue>1</issue>
          <fpage>25</fpage>
          <lpage>32</lpage>
          <pub-id pub-id-type="doi">10.1177/1461444807075201</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref79">
        <label>79</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Vuojärvi</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <source>Conceptualising Personal and Mobile Learning Environments in Higher Education: Focus on Students' Perspective. Academic Dissertation. Acta Universitatis Lapponiensis 266</source>
          <year>2013</year>
          <publisher-loc>Rovaniemi, Finland</publisher-loc>
          <publisher-name>Lapland University Press</publisher-name>
        </nlm-citation>
      </ref>
      <ref id="ref80">
        <label>80</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Peek</surname>
              <given-names>ST</given-names>
            </name>
            <name name-style="western">
              <surname>Wouters</surname>
              <given-names>EJ</given-names>
            </name>
            <name name-style="western">
              <surname>van Hoof</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Luijkx</surname>
              <given-names>KG</given-names>
            </name>
            <name name-style="western">
              <surname>Boeije</surname>
              <given-names>HR</given-names>
            </name>
            <name name-style="western">
              <surname>Vrijhoef</surname>
              <given-names>HJ</given-names>
            </name>
          </person-group>
          <article-title>Factors influencing acceptance of technology for aging in place: a systematic review</article-title>
          <source>Int J Med Inform</source>
          <year>2014</year>
          <month>04</month>
          <volume>83</volume>
          <issue>4</issue>
          <fpage>235</fpage>
          <lpage>48</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://linkinghub.elsevier.com/retrieve/pii/S1386-5056(14)00017-3"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.ijmedinf.2014.01.004</pub-id>
          <pub-id pub-id-type="medline">24529817</pub-id>
          <pub-id pub-id-type="pii">S1386-5056(14)00017-3</pub-id>
        </nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
