A novel coronavirus, severe acute respiratory syndrome 2 (SARS-CoV-2), was identified in Wuhan, China, in December 2019; the virus quickly spread worldwide and was labeled a pandemic by the World Health Organization on March 11, 2020 [1]. SARS-CoV-2 can result in severe respiratory infection, causing coronavirus disease (COVID-19). The rapid spread and high estimated infectivity of SARS-CoV-2 coupled with the severity of COVID-19 led to widespread shuttering of businesses and implementation of mandatory stay-at-home orders across the United States. Although reported cases are not stratified by race and ethnicity in all US jurisdictions or may be incompletely reported due to missing information, available data indicate the emergence of racial and ethnic disparities in the occurrence of COVID-19 [2], mirroring disparities that have been well characterized in other disease processes.

Racial and ethnic disparities in COVID-19 occurrence may be due to multiple factors. Asian, Black, and Hispanic Americans are all more likely to be uninsured than non-Hispanic White Americans [3], resulting in reduced access to health care. Increased prevalence of preexisting conditions that are known to be associated with poor outcomes in COVID-19 patients, including diabetes [4,5] among Black and Hispanic people and hypertension [5-7] among Black people, may increase susceptibility and disease severity in these populations. The long-term effects of structural racism and income inequality that cause larger proportions of people of color to work in conditions that are not conducive to social distancing [8] or to live in crowded conditions [8,9] also facilitate efficient transmission of the virus. In addition to combatting these existing disparities, in a rapidly evolving pandemic, accurate information is necessary for individuals to exercise appropriate prevention and care-seeking behavior. We examined whether there were racial or ethnic differences in knowledge, stigma, and experience of symptoms during the early stages of the COVID-19 pandemic.

Advertisements on Facebook, Snapchat, and Twitter were used to conduct a nationwide web-based survey with US adults aged 18 years or older from March 27 through April 1, 2020 [10]. Participants were eligible to participate if they were at least 18 years of age. We sought to obtain a racially and ethnically diverse sample by overrecruiting people of color and Hispanic participants. Therefore, because a sufficient number of non-Hispanic White participants had been enrolled, enrollment of non-Hispanic White participants was stopped on the final day of recruiting to increase the representation of communities of color in the survey. Participants were not compensated for completing the survey. All study procedures were reviewed and approved by the Emory University Institutional Review Board.

The survey included questions on knowledge of effective prevention methods, a COVID-19 stigma scale, and current COVID-19–related symptoms (see Multimedia Appendix 1). We used chi-square tests with Holm Bonferroni correction to account for multiple comparisons to assess differences across these domains based on race and ethnicity (Asian, Hispanic, non-Hispanic Black, non-Hispanic White, and other/multiple race). Corrected P values <.05 were considered statistically significant. The full survey is included in Multimedia Appendix 1. All analyses were conducted using SAS 9.4 (SAS Institute).

A total of 1435 participants consented to participate and completed the survey. Of the 1435 participants, 52 (3.6%) were Asian, 548 (38.2%) were Hispanic, 158 (11.0%) were non-Hispanic Black, 587 (40.9%) were non-Hispanic White, and 90 (6.3%) were of other or multiple races. There were race and ethnicity differences in gender, annual income, educational status, and geographic region of residence across categories of race and ethnicity (Table 1).

When asked whether they were currently experiencing symptoms possibly related to COVID-19, a plurality of participants (635/1435, 44.3%) reported no symptoms (Table 2). Of those experiencing COVID-19 symptoms, the most frequently reported symptoms were cough (328/1435, 22.9%), sneezing (322/1435, 22.4%), and headache (311/1435, 21.7%). The only symptom that differed by race/ethnicity was sore throat. Racial/ethnic differences were observed in perceived likelihood of currently having COVID-19 by race/ethnicity. Hispanic (192/544, 35.3%) and non-Hispanic Black (54/157, 34.4%) participants were more likely to report that it was somewhat likely, likely, or very likely that they currently had COVID-19 compared to Asian (11/51, 21.6%) and non-Hispanic White (121/580, 20.9%) participants.

When asked about their knowledge of numbers of cases and COVID-19 deaths, non-Hispanic White (376/587, 64.1%) and Asian (32/52, 61.5%) participants were more likely to correctly estimate that there were currently 100,000 or more cases in the US compared to Hispanic (269/548, 49.1%) and non-Hispanic Black (73/158, 46.2%) participants. No differences were observed in the estimated number of deaths expected from COVID-19 by the end of 2020.

Non-Hispanic White (180/587, 30.7%) and Asian (13/52, 25.0%) participants were more likely to answer all 14 COVID-19 knowledge scale questions correctly compared to Hispanic (108/548, 19.7%) and non-Hispanic Black (25/158, 15.8%) participants. Overall, 46.6% of participants endorsed at least one stigmatizing statement related to COVID-19, with no difference by race.

Overall, 954/1247 participants (76.5%) indicated willingness to participate in future research studies of diagnostic and serologic testing for SARS-CoV-2, with no differences by race and ethnicity.