We conducted a systematic literature review using four large databases to collect articles related to HOHC systems. We performed a qualitative content analysis to extract themes of facilitators and barriers to HOHC systems from each of the included articles.

Four large digital libraries—Scopus, Association for Computing Machinery (ACM), PubMed, and Web of Science—were searched for articles about HOHC systems. We selected these databases because they include a large number of health journals. After identifying the digital libraries, with the help of a professional librarian, specific keywords were used to search for the needed articles from the identified databases. The keywords used in the search were as follows: (“eHealth” OR “health” OR “Telemedicine” OR “mHealth” OR “Mobile health”) AND (“video conferencing” OR “Electronic consultation” OR “online consultation” OR “e consultation”). The keywords were tested on Scopus, ACM, and Web of Science databases to check their validity with three constraints (ie, controls) on the search. The constraints were made to search for (1) articles only, (2) articles published in English, and (3) articles published from 2008 to 2018, as shown in Table 1. Further, PubMed was searched for (1) clinical trial and journal articles, (2) articles with human subjects, and (3) articles published in English in the last 10 years with the following Medical Subject Headings (MeSH) as keywords: “Telemedicine” AND “Remote Consultation.”

After the first test, several decisions were made: (1) to expand publication year to include papers published from all years up to 2018, (2) to search for English articles only, and (3) to use constraints while searching the digital libraries.

The search for the identified keywords on the identified databases above was conducted on November 15, 2018, and an additional search on PubMed was conducted on November 15, 2019, which returned a total of 2518 English articles that were published from all years up to 2018. The details of each database search are as follows:

After collecting 2518 articles, 200 duplicate articles were removed, which left 2318 articles for the screening process. The screening process was completed by all authors assessing the eligibility of each article until consensus was reached. After the screening review of each article’s title and abstract, 2049 articles were removed because they did not meet the inclusion criteria, which left 269 articles for the next step.

In this process, all authors assessed the 269 articles following the inclusion and exclusion criteria, and meetings were held discussing the eligibility of articles until consensus was reached. Thus, the authors included 45 articles in the final review, as shown in Figure 1.

Manual qualitative content analysis was performed on the included studies in order to identify facilitators and barriers to real-time HOHC systems and the results were categorized into two main categories: facilitators and barriers [19]. In order to perform this thematic data extraction, the researchers predefined the facilitators and barriers to HOHC systems based on the Theory of Planned Behavior (TPB) and the Health Belief Model (HBM). According to the TPB, an individual’s intention to perform a certain behavior is influenced by internal and external factors. Internal factors are the individual’s characteristics, differences, knowledge, skills and abilities, emotions, and compulsions that influence the performance of intended behavior [20]. External factors are situational factors, such as time and opportunities, and depends on the action of other people who influence an individual’s control over the intended behavior [20]. According to the HBM, an individual will likely engage in health-related behaviors based on his or her perception of several variables that influence the uptake of health services. First, perceived susceptibility refers to the individual’s assessment of the possibility of getting a disease. Second, perceived severity is about the individual’s judgment of the seriousness of the disease. Third, perceived benefit reflects the individual’s evaluation of the effectiveness of the available action to reduce the threat of illness or disease. Fourth, perceived barrier refers to obstacles that prevent an individual from performing a healthy activity, such as high cost, time-consumption, side effects, and inconvenience. Fifth, cue to action refers to the internal and external process of decision making to perform or accept a healthy action. Finally, self-efficacy refers to an individual’s confidence in his or her ability to successfully perform a recommended health action [21,22].

Based on the above predefinition, facilitators to HOHC systems are the information and data gathered from examining positive feedback, comments, factors, and indicators mentioned in each article that helped in the users’ uptake of the system. Further, facilitators are divided into two subcategories: internal and external. The internal facilitators refer to the positive feedback, comments, factors, and indicators that have an effect on the user’s behavior and motivation while using the system. The external facilitators refer to the positive feedback, comments, factors, and indicators about the environment surrounding the system’s usage and the system itself.

The barriers to HOHC systems are the information and data gathered from examining negative feedback, comments, factors, and indicators mentioned in each article that hindered users’ uptake of the system. Further, the barriers are divided into two subcategories: internal and external. The internal barriers refer to the negative feedback, comments, factors, and indicators that have an effect on the user’s behavior and motivation while using the system. The external barriers refer to the negative feedback, comments, factors, and indicators about the environment surrounding the system’s usage and the system itself.

The first author (HKYA) analyzed all the articles and extracted the facilitators and the barriers to the HOHC system. The second and third authors (KTW and EVG) validated the results of the extracted information by performing a full-text reading of the articles. After that, several group meetings were held to discuss the discovered themes and data until consensus was achieved among all authors. The authors also extracted basic characteristics from each study, summarized their aims, and described the HOHC system that was used in each study. Further, they summarized the effectiveness of each HOHC system used in each article and the patients’ satisfaction with it.

We analyzed each study qualitatively to extract themes of facilitators and barriers to HOHC systems. Also, the results of the analyses indicate that HOHC systems use video conferencing via different platforms as a medium to facilitate online consultations. Further, HOHC systems have been used for different types of diseases with patients of different ages and characteristics.

HOHC was provided to male and female patients with ages ranging from less than 1 year old to over 80 years old. It was also provided to patients with different health conditions and diseases (see Table 2). The duration of HOHC usage ranged from 2 weeks to 12 months and the studies were conducted in 11 different countries: United States (n=23), Australia (n=5), Canada (n=4), Italy (n=4), United Kingdom (n=2), China (n=1), Spain (n=1), Korea (n=1), Norway (n=1), Denmark (n=1), and Iran (n=1). Table 3 provides a comprehensive summary of the characteristics of each study [14-17,23-63]. Further, for detailed information about each study aim and the system used, see Table A1-1 in Multimedia Appendix 1.

HOHC systems in all reviewed articles featured the use of synchronous video conferencing systems or software as a medium to facilitate the communication between a health professional and a patient or a patient’s carer. The video conferencing feature was a part of a complex telemedicine system or a simple stand-alone software program on a patient’s mobile phone or personal computer. The results showed that 25 of the studies conducted online consultation via specially developed telemedicine systems that provide video conferencing as part of its main services. The remaining studies used off-the-shelf video conferencing software to conduct the home online consultation. In total, 4 studies used Skype software, 4 studies used Vidyo software, 5 studies used Web-based video conferencing systems, 2 studies used Adobe Connect, and other studies used different platforms, including Cisco WebEx, Moodle, Cisco Jabber, Facebook Messenger, or the Microsoft NetMeeting system (see Table A2-1 in Multimedia Appendix 2).

The complexity of the HOHC system used was related to the complexity of the patient’s health condition. If a patient had multiple and complex health conditions, a complex telemedicine system was used for monitoring his or her health condition. In contrast, when a patient had a single health condition, a simple system was used for remote treatment (see Table 4).

The effectiveness of an HOHC system to deliver remote consultation is determined by its ability to achieve the health care outcomes as reported by the authors of each article. Out of 45 included studies, 44 (98%) reported that online consultation systems were effective in improving patients’ overall health conditions and in assessing patients’ health conditions successfully. However, the level of evidence [64] is different in each study, ranging from Level II to Level VI. Despite this different in range, the included studies presented a medium-high strength on the level-of-evidence grade [64], with the majority of the articles falling under Level II and Level IV (see Table A3-1 in Multimedia Appendix 3).

Several studies reported that the online consultation was effective and was as good as in-person consultation [14,27,28,32-35,37,38,46,54,55]. However, 1 study reported that patients preferred a combination of online consultation and face-to-face consultation [43], and 2 studies reported that participants preferred face-to-face consultation [34,56].

On the other hand, the study by Peel et al [49] reported failure in implementing a home telerehabilitation program of geriatric rehabilitation for elderly people. The program faced challenges with patients who had low mobility, complex social problems, low hearing and vision, and cognitive impairment. Also, patients required assistance from a third person to use the system. However, the authors concluded that the system had the potential to deliver remote rehabilitation services, but it faced many barriers that needed to be overcome to ensure its effectiveness.

In total, 12 studies reported on participants’ satisfaction with the use of HOHC systems. In Thomas et al [55], parents’ satisfaction with the remote treatment received an average score of 9.5 out of 10. In the study of Eslami Jahromi and Ahmadian [35], 16 out of 30 patients were satisfied with the teletherapy services. Bernocchi et al [27] reported that 100% of patients were satisfied with the program: 60% were very satisfied and 40% were satisfied. Dimitropoulos et al [32] reported that participants rated their satisfaction with the program with a mean rating of 4.71 out of 5. In Azar et al [25], the overall satisfaction with the program was high, with a mean rating of 4.1-4.4 out of 5. All patients in the Woodend et al [60] study showed high satisfaction with the program at different stages: 92% in the first month, 92% in the second month, and 97% in the third month. Walsh and Coleman [57] found that patients’ satisfaction with the program was overwhelmingly favorable. In the Pietrabissa et al [50] study, the level of participants’ satisfaction was rated as 4 out of 5. Further, Edwards and Patel [33] reported that 95% of patients and 98% of health care staff were very satisfied with the 2619 home televisit sessions. In Westra and Niessen [58], patients’ satisfaction with the HOHC system received a mean rating score of 3.91 out of 5. Also, in the Portaro et al [51] study, participants reported that the system was reasonable and user friendly. In the study by Wu and Keyes [14], all 17 participants expressed a favorable opinion of the program.

The identified facilitators and barriers from each article are summarized in Table 5 (facilitators) and Table 6 (barriers), which provide results for each facilitator and barrier addressed in the included studies. Further, thematic extraction of facilitators and barriers from each article can be found in Table A4-1 in Multimedia Appendix 4.

HOHC systems in all reviewed articles required patients to have access to the Internet and phone line services to receive the needed health care services at their home. All studies used Internet access as an inclusion criterion in order to participate in the study. However, some studies reported that participants dropped out due to later Internet connection issues [14,45,55,56].

Internet speed that affected the quality of the HOHC was mentioned in 20 studies. In total, 15 out of 20 studies (75%) reported that slow Internet speed during the consultation resulted in poor video and audio quality, loss of connection, and participants’ frustration [14,23,27,28,32,33,35,39,40,42,43,47, 53-55]. On the other hand, fast Internet speed was reported in 5 out of the 20 studies (25%), which had a positive impact on the communication quality between patients and care providers [17,28,42,54,55].

Poor signal from the wireless and 3G networks was reported in 3 studies, which affected the quality of the online consultation [29,42]. For example, the wireless and 3G network signals were affected by the home interior and the weather conditions [54], which reduced the wireless and 3G signal strength.

Ease of use of the HOHC system was related to how easily patients and clinicians were able to navigate and use its services. Ease of use was reported by patients and clinicians in 22 studies as a key factor of system effectiveness, high satisfaction, and the acceptability of the HOHC system [16,17,24,25,28-30, 32,35,37,40-43,48,49,51,53,55,57,61]. On the other hand, in 7 studies some participants reported that they had difficulty using the online consultation system. Most of them reported that they had difficulty navigating or installing the system on their computer [14,15,34,39,53,58,60].

Participants’ familiarity with the technology used for HOHC was reported in 6 studies and helped them to accept and adapt to it faster [26,29,35,41,56,59]. For example, participants were familiar with Skype because it is a popular platform for online communication [35]. In contrast, patients’ lack of knowledge, unfamiliarity with communication technology, and fear of the unknown resulted in resistance to the use of the HOHC technology, which was reported in 11 studies [23,26,33,34,36,37,41,43,54,56]. Also, nurses’ resistance to the system limited the uptake of the HOHC technology [57].

Patients’ training was reported in 20 studies, which helped patients to use the system and its equipment easily [16,24,27,30,31,35-37,39,40,46,47,49,53-55,57,62]. Training was provided by the health care provider to patients before starting the online therapy; training was given in the following forms: face-to-face [25,30,39,61,62], through video orientation, or though manual documentation [32]. The type of training provided depended on the type of health condition and the specific online consultation system. For example, participants in the multiple sclerosis study completed 192 online sessions, 40 of which were online training sessions [44]. However, the lack of patients’ training and knowledge regarding technology use was considered as a barrier to HOHC in 3 studies [23,30,41].

Training for clinicians to use the online consultation system was reported in 10 studies. In-person training aimed to familiarize clinicians with the system, the system’s equipment, and the treatment procedures [15,25,26,30-32,36,39,46,49,52, 55,56]. In addition, few authors reported that individual clinicians’ skills, such as communication skills, helped in delivering the best care for patients and contributed to the treatment plan in some studies [24,25,45,63]. However, lack of staff training affected the uptake of online consultation. For example, Peel et al [49] indicated frequent changes of staff during the study and their lack of training limited the uptake of the eHAB™ system.

Saving costs was reported in 21 studies as an advantage of using HOHC. In some studies, cost savings were calculated based on the cost of the traveled mileage per patient [16] or were reported without details of cost savings [15,23,31,35,38,42-44, 48,50,56,58]. Other studies compared the cost of online consultation to traditional face-to-face consultation [14,26,29,33,36,39,47,57].

Reducing travel time was reported in 15 articles as an advantage of using HOHC. Participants reported that online consultation eliminated the burden of traveling from home to health center or outpatient unit [15,16,23,28,29,31,35,42-44,48,54,58]. In addition, both reducing travel and waiting times were reported in 9 articles as an advantage of using HOHC. Patients reported that HOHC eliminated their waiting times for therapy [15,23,28,31,35,38,44,58] and clinicians reported that it reduced their travel time; thus, there was no waiting time [54].

Security was reported in 10 studies as an advantage of using HOHC to protect the patients’ information. Skype was used in a few studies, which provides 256-bit encryption as a security feature [35,59]. Further, other studies used Vidyo as a platform, which provides a higher level of security as it is compliant with the Health Insurance Portability and Accountability Act (HIPPAA) [16]. Some studies implemented security in their system to comply with HIPPAA [38], and other studies did not specify the type of implemented security features [26,36,37,46,51,58]. However, few studies indicated that participants had security concerns about online consultation [40,42]. Further, Skype is not HIPAA compliant, as mentioned in Williams et al [59], and may not provide a high level of security.

Privacy was reported in 12 studies in terms of saving participants’ data privately and creating a sense of privacy at home while conducting the online consultation [14,23,26,30,31,36,37,41,48,53,57,61]. In contrast, 5 studies indicated that participants had a concern about their privacy. Participants who had not disclosed their health condition to their family indicated that during the online consultation the information might be overheard by one of their family members [42,59]. Also, participants reported that someone living at home could be seen by others during the video conferencing consultation [29,31,40].

Managing participants over the HOHC was reported in 7 studies as an advantage. Clinicians reported that the online consultation system was faster at documenting and saving patients’ records [38]. Also, online consultation provided greater scheduling capability and flexibility for patients and clinicians [15,37,43,48,53]. Further, some methods of online consultation enabled clinicians to take control over participants’ computers when necessary [44]. However, other studies reported that patients had time and scheduling conflicts with the online treatment time [34,59] due to a medical appointment or medical emergency, which made them skip some of the online treatment sessions [48].

Participants in 11 studies reported that HOHC was convenient at meeting their health needs. The convenience aspect of the online consultation was related to eliminating travel and waiting times, saving costs, and completing the consultation from the comfort of their home at any time [14,15,17,31,40,42, 43,48,50,55,59]. On the other hand, in the Ehlers et al [34] study, some of the women reported that wearing an accelerometer was inconvenient. In Peel et al [49], the weight and size of the device made it challenging for patients to carry around the home and to store at home due to the lack of sufficient space.

Motivation and engagement were reported in 8 studies as advantages of conducting HOHC. Motivation and engagement were related to the encouraging and engaging communication between therapist and participants and among participants themselves [14,15,26,32,46,50,53,55]. However, 1 study reported that patients’ engagement was difficult with young children present [24].

The HOHC system approach enabled better treatment compliance for patients. It was reported in 5 studies that patients showed better compliance, adherence, and accountability to the overall treatment, which helped them to recover faster during online treatment [26,37,38,43,44].

HOHC improved patients’ access to health care services, which was reported in 9 studies. Patients reported that online consultation helped them to gain access to specialist care [42,51], to general care, and to real-time assessment [24,35,38,43,45,59,62]. However, 1 study reported that participants had less access to care providers, due to a technical issue. For example, in the Westra and Niessen [58] study, patients in the online group perceived accessibility and convenience to be lower, compared to the patients in the control group, due to lack of physical presence.

In total, 2 studies reported that online consultation enabled body language communication and created a feeling of presence between patients and therapists. For example, Williams et al [59] reported that online consultation enabled psychologists and psychiatrists to read patients’ body language cues. Participants also rated the feeling of presence with a score of 4.17 out of 5 during their online therapy session [41]. On the other hand, several studies reported that body language and social presence were disadvantages of online consultation. For example, lack of eye contact and emotional expression were reported by 24 participants, who said that it made them feel uncomfortable [35]. Further, 5 women reported that lacking a social presence made them feel disconnected during the online consultation [34]. Also, 52% of elderly patients, with a mean age of 76.75 years, reported that they did not like the lack of physical contact during a TeleHomeCare visit [31]. Moreover, clinicians reported difficulties engaging with very young children during the online therapy [24] or reported an inadequate ability to physically examine their patients [58].

Patients reported that their interactions with the clinical staff during face-to-face treatment before the online consultation helped them to be more comfortable and to have a good relationship with clinical staff during the online consultation [27,29,31]. Furthermore, patients’ past in-person treatment experience with a therapist encouraged them to participate in online consultation treatment [50].

Several studies reported that providing feedback and technical support helped in the uptake of online consultation. Participants reported that they felt well-supported during the online consultation by clinicians [15,26], which helped them to be more social with others [29,43]. The technical support helped participants overcome technical issues in a timely manner [14,16,44,53,58]. In total, 2 studies reported that organizational support [33] and health insurance coverage helped in the uptake of the online consultation [57]. However, lack of online consultation system integration and cross-synchronization with another system at the hospital prevented documentation of patients’ records [57] and prevented them from accessing desired features offered by other platforms [15]. Also, incompatibility of the HOHC technology with patients’ devices prevented them from participating in the online consultation. For example, 5 individuals withdrew from the Beck et al [17] study because the Vidyo software did not work with their old operating systems. Several studies indicated that law and policy prevented the uptake of online consultation. Most of the laws and policies were related to legal issues and reimbursement that the health organization did not support [16,17,26,29,33,36,41,61].

Involving health care experts during the development of the online consultation application enabled better patient experiences. For example, 1 study reported that the development of the TeleBurn app involved pediatric burn care, health communication, nursing, public health, biostatistics, information technology, and clinical psychology experts, which resulted in an app that helped patients to heal faster and to comply to the treatment better than face-to-face treatment [38].

Several studies reported that family involvement during the treatment to provide the care needed for their family member helped in the uptake of the online consultation. Family carers were involved in the treatment of family members who needed assistance from the beginning of the treatment, especially with patients younger than 12 years old or above 69 years old [15,27,32,39,43,51,62]. In contrast, 1 study reported a failure in implementing online consultation for the elderly because it required assistance from a third person and no family members were available for the study [49].

In total, 7 studies reported that home layout complications and lack of a dedicated room to conduct the online consultation reduced the quality of the consultation. Distractions from the surrounding home environment reduced patients’ attention during many online sessions because other family members were doing other home tasks, such as cooking, watching TV, answering the phone, and talking with other members of the family [32,34,40,49,53,59].

In this article, we reviewed 45 studies that used HOHC systems to deliver real-time remote health care services to patients in their homes. This review contributes to the literature by conceptualizing a framework of facilitators and barriers to HOHC. In this section, we discuss the framework and then outline the practical implications and limitations of this review.

The Results section identified a framework of four requirements—17 facilitators (10 internal and 7 external) and 8 barriers (5 external and 3 internal)—categorized as internal and external influencers on HOHC, as shown in Table 7.

External factors refer to the environment surrounding the system’s usage and the system itself that influence users’ acceptance and use of HOHC services [20-22]. This includes the technological capabilities of the HOHC system and the user capabilities of the patient and the clinician. The technological capabilities include the representation of the information, since online consultation simulates a face-to-face consultation between patient and health professional [64]. In fact, the results showed that patients and clinicians are able to communicate over video conferencing, and some patients are willing to pay for the online consultation because they found that it provides a similar experience to an in-person consultation. User capabilities include the way the patient explains or presents his or her health condition to his or her health professional, as well as the way the health professional interviews the patient to elicit all the needed information in order to perform a successful diagnosis [64]. Internal factors refer to the users’ behaviors and motivations while using and interacting with the system, which are keys to patients’ acceptance of the use of this technology. These factors include patients’ beliefs and patients’ perceptions of the relative advantages and disadvantages of HOHC compared with existing health care practices [20-22]. Figure 2 provides an illustrative overview of the identified framework of requirements, facilitators, and barriers to HOHC, as well as the correlation between facilitators and barriers.

There are four requirements for HOHC. Security and privacy are very important requirements because the communication supported by HOHC is personal and confidential. The security and privacy of the HOHC can be considered from the aspect of its compliance with the HIPAA. This act sets the standard for security and privacy for patients’ sensitive health information and records that are held or transferred in electronic form between health care providers and patients [16,28]. Another requirement is the Internet service availability for this type of consultation, without which patients cannot access online consultation. The availability of a device is a requirement and it can be either a personal device (eg, mobile phone, tablet, or PC) or a telemedicine device provided by the health care provider to patients. These requirements are essential for delivering any HOHC, and online consultation cannot be performed without them.

High Internet speed affects the quality of the consultation and can positively influence patients’ acceptance of and satisfaction with HOHC. In fact, the results indicate that patients and clinical staff showed higher satisfaction and acceptance of online consultations when the Internet speed was high. However, low Internet speed can negatively influence patients’ acceptance of and satisfaction with HOHC. This indicates that there is a correlation between Internet speed and patients’ convenience with, satisfaction with, and acceptance of HOHC, which might be one of the reasons that some patients preferred in-person consultations rather than HOHC when the Internet speed was low.

Poor network services and wireless signal coverage are barriers to HOHC, which can occur because of problems with the network services and coverage themselves or because of home indoor and outdoor obstruction. This barrier affects Internet speed, which influences the quality of the HOHC; therefore, it influences patients’ acceptance of and satisfaction with HOHC. Thus, this indicates a correlation between poor networks and slow Internet speed.

Saving costs on health care services for both health care providers and patients is a key driver for adopting HOHC. It is evident that online consultations reduce service costs as well as eliminate travel costs and wait times for health care providers and patients, indicating a correlation between saving costs for patients and convenience.

Patients’ and clinicians’ training is considered a facilitator by both patients and clinicians, which enables them to use the HOHC system easily. Conversely, lack of training poses a challenge to the use of online systems and might influence users’ adoption and increase their resistance to them.

The ease of use of the online consultation system can positively influence patients’ acceptance of and satisfaction with HOHC. However, some patients with complex health conditions require complex HOHC systems, which include vital signs monitoring sensors linked to the health care provider’s data center for real-time monitoring or requiring patients to regularly report data to the health care provider. These complex systems are not easy to use, and patients might encounter technical issues and difficulties while using them. These difficulties negatively influence patients’ acceptance of and convenience with HOHC, which increase patients’ reluctance to use the technology. Therefore, the difficulty in using the system as well as the complexity of the system itself are related to patients’ complex health conditions. However, technical support, regarding technical issues during the online consultation, which patients can receive over the phone, via an online session, or by controlling their devices remotely, can reduce system difficulty.

The correlation between management and providing support to patients can be supported by the flexibility offered by online consultation in the terms of choosing a suitable time for the online treatment, documenting and tracking patients’ treatment progress in real time, as well as giving feedback to patients in a timely manner. Also, the flexibility and scheduling capabilities of online consultation systems promote convenience and compliance with treatment.

Compliance with treatment over HOHC can be more effective than in-person treatment, as it is enforced by the HOHC approach and the system as a whole. This is because patients are held accountable and are encouraged by their family members to follow the online treatment procedures. Also, compliance is aided by the convenience of the online consultation, as patients follow the treatment from the comfort of their homes at a convenient time that suits them. This indicates that compliance with treatment has a correlation with convenience and family involvement.

The lack of organizational support regarding the law, policy, and reimbursement are some of the most argued barriers to online consultation because health insurance companies do not fully support this type of consultation [41]. In addition, lacking support from hospitals to integrate HOHC with patients’ health records, for full record documentation, and for cross-synchronization with other system platforms is limiting the adoption of HOHC.

Accessibility to specialist care is one of the drivers that promote the use of HOHC, since it improves patients’ access to health care specialists, despite patients’ remote locations and lack of experts in their area.

Home obstructions are a barrier to online consultation. Patients are distracted by other things happening at home and the family members around them, which affects their privacy concerns.

Saving time for both health care provider staff and patients is one of the most appreciated facilitators of HOHC. Eliminating travel time is important, especially for patients in underserved areas or for nurses who perform in-person home visits. Online consultation also promotes convenience by eliminating patients’ waiting times at hospitals, outpatient units, and specialist offices.

Online consultation resistance often comes from patients’ lack of knowledge, unfamiliarity with technology, and resistance to change to new approaches. In this context, it should be noted that patients’ familiarity with the system is important in reducing their resistance. Based on the reviewed papers, users who were familiar with similar and mainstream video conferencing systems did not show resistance to online consultations. Also, patients’ past treatment experiences and familiarity with clinicians can assist in reducing technology resistance. Patients who previously had treatment for a specific health condition or patients who were familiar with the clinician who provided care for them during face-to-face consultation were more open to use HOHC systems and were encouraged to use them.

HOHC systems enable engagement and motivation between therapists and participants. Skilled therapists are able to engage patients in the treatment and motivate them to make healthy progress. Video conferencing can enable excellent body language and communication between patients and therapists, thus supporting patients’ confidence. However, lack of eye contact as well as physical and social contact (ie, poor body language and communication) during online consultation can be a barrier as well. In this context, emotional support is provided in real-time feedback, which encourages patients to commit to the treatment program.

Patients’ positive perceptions of the system’s privacy and security—the sense of privacy while conducting the online consultation at home—can encourage the use of HOHC. However, despite the technical effort to ensure patients’ data security and privacy, some patients show concern regarding the security of the system and their personal privacy. Patients’ perceptions of HOHC privacy and security are subjective; thus, it can be considered as both a facilitator and a barrier, positively or negatively influencing the view and understanding of the HOHC system.

Most patients gain a high level of convenience when HOHC systems are easy to use and reduce travel time and costs, which is reflected in their satisfaction with online consultation. Also, patients are satisfied with HOHC because it is effective and convenient and provides a similar experience to face-to-face (ie, in-person) consultation. However, a small number of patients preferred face-to-face consultation for their own reasons, such as their belief that the physical presence of a health care professional would enable superior interpretation of body language and emotional expression or simply because it was their personal preference. Also, patients’ satisfaction with health care alternatives (ie, satisfaction with primary health care) has a negative influence on their attitudes toward the adoption of e-consultation and on their perception of the relative advantage of HOHC [64].

HOHC systems are effective in delivering health care services, as indicated in 44 out of 45 (98%) of the included studies. However, the use of HOHC systems with young and old patients might be difficult because young children might not engage in the online treatment [24] and patients older than 80 years might find it challenging to use them [49]. Since these results were reported only in 2 studies, and other studies with younger and older patients have been successful without reporting additional difficulties, we, therefore, do not consider age to have a significant influence on the use of HOHC.

Patients’ different health conditions, especially ones that require physical examinations, might be perceived as less accessible to clinicians by patients. Patients who underwent plastic surgery perceived that HOHC resulted in lower access to clinicians, who are to examine their surgical scars; however, the findings of that study were not significant [58]. In contrast, using HOHC with patients with burn injuries, which require a physical examination, has been successful [38]. Therefore, we can argue that the varying health conditions of patients have no significant influence on the use of HOHC.

The proposed framework (see Figure 2) of HOHC facilitators and barriers can be used for future analysis or during any development of real-time HOHC systems in a health care context. Health care providers, during the development of HOHC systems, can use the framework as a guideline to emphasize the facilitators and minimize or eliminate the barriers to ensure the delivery of effective online consultations to their patients at home. Also, this framework can be used as a clear guideline for researchers who are testing new approaches with which to implement or use HOHC to deliver care to patients with specific diseases.

There are several limitations to our study. First, our systematic review used the qualitative content analysis method to discover themes of facilitators and barriers to HOHC systems. This method is subject to our subjective interpretation of the findings, which may have introduced bias into the study. Also, our study is focused on a specific type of online health consultation system: a real-time HOHC system. Thus, the results may not be generalizable to all online health consultation systems, such as store-and-forward online health consultation.

A meta-analysis of the included studies was not conducted, as the number of participants in the reviewed articles varied considerably (ie, from 2 to 927 participants). Also, some studies conducted a randomized controlled trial, while other studies used cross-sectional interviews. Moreover, there could be bias in the included studies— selection bias, method bias, and reporting bias—but we did not conduct a risk-of-bias assessment.

However, despite these limitations, most of the included articles elicited similar requirements, facilitators, and barriers to HOHC, which propose a strong framework of facilitators and barriers for HOHC systems.

HOHC systems can be of great benefit to patients in terms of convenience, reliability, health care availability, and cost savings. HOHC systems are tailored to meet patients’ needs, as well as to ensure effectiveness in improving patients’ well-being and satisfaction with the health care provided. Patients’ acceptance of HOHC is enforced by the facilitators, which promote effective and convenient remote treatment. However, some patients influenced by the identified barriers preferred face-to-face consultation and showed resistance to the HOHC. Future work will focus on further testing of the framework with a well-established HOHC system that receives full organizational support and a study with a large sample size of patients in order to validate the framework.