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<?covid-19-tdm?>
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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v22i12e24775</article-id>
      <article-id pub-id-type="pmid">33290247</article-id>
      <article-id pub-id-type="doi">10.2196/24775</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Paper</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Original Paper</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Subjective Well-Being of Chinese Sina Weibo Users in Residential Lockdown During the COVID-19 Pandemic: Machine Learning Analysis</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Eysenbach</surname>
            <given-names>Gunther</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Li</surname>
            <given-names>Ang</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Xue</surname>
            <given-names>Jia</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author">
          <name name-style="western">
            <surname>Wang</surname>
            <given-names>Yilin</given-names>
          </name>
          <degrees>BSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-3710-1123</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Wu</surname>
            <given-names>Peijing</given-names>
          </name>
          <degrees>BSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <xref rid="aff4" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-9108-5270</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Liu</surname>
            <given-names>Xiaoqian</given-names>
          </name>
          <degrees>DPhil</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-2740-8420</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Li</surname>
            <given-names>Sijia</given-names>
          </name>
          <degrees>BSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-4952-4123</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Zhu</surname>
            <given-names>Tingshao</given-names>
          </name>
          <degrees>DPhil</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-0020-3812</ext-link>
        </contrib>
        <contrib id="contrib6" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Zhao</surname>
            <given-names>Nan</given-names>
          </name>
          <degrees>DPhil</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Key Laboratory of Behavioral Science</institution>
            <institution>Institute of Psychology</institution>
            <institution>Chinese Academy of Sciences</institution>
            <addr-line>16 Lincui Road</addr-line>
            <addr-line>Chaoyang District</addr-line>
            <addr-line>Beijing, </addr-line>
            <country>China</country>
            <phone>86 010 64101377</phone>
            <email>zhaonan@psych.ac.cn</email>
          </address>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-8119-4577</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Key Laboratory of Behavioral Science</institution>
        <institution>Institute of Psychology</institution>
        <institution>Chinese Academy of Sciences</institution>
        <addr-line>Beijing</addr-line>
        <country>China</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Department of Psychology</institution>
        <institution>University of Chinese Academy of Sciences</institution>
        <addr-line>Beijing</addr-line>
        <country>China</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>Department of Psychology</institution>
        <institution>Nankai University</institution>
        <addr-line>Tianjin</addr-line>
        <country>China</country>
      </aff>
      <aff id="aff4">
        <label>4</label>
        <institution>Beijing University of Posts and Telecommunications</institution>
        <addr-line>Beijing</addr-line>
        <country>China</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Nan Zhao <email>zhaonan@psych.ac.cn</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <month>12</month>
        <year>2020</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>17</day>
        <month>12</month>
        <year>2020</year>
      </pub-date>
      <volume>22</volume>
      <issue>12</issue>
      <elocation-id>e24775</elocation-id>
      <history>
        <date date-type="received">
          <day>7</day>
          <month>10</month>
          <year>2020</year>
        </date>
        <date date-type="rev-request">
          <day>30</day>
          <month>10</month>
          <year>2020</year>
        </date>
        <date date-type="rev-recd">
          <day>19</day>
          <month>11</month>
          <year>2020</year>
        </date>
        <date date-type="accepted">
          <day>5</day>
          <month>12</month>
          <year>2020</year>
        </date>
      </history>
      <copyright-statement>©Yilin Wang, Peijing Wu, Xiaoqian Liu, Sijia Li, Tingshao Zhu, Nan Zhao. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 17.12.2020.</copyright-statement>
      <copyright-year>2020</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="http://www.jmir.org/2020/12/e24775/" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>During the COVID-19 pandemic, residential lockdowns were implemented in numerous cities in China to contain the rapid spread of the disease. Although these stringent regulations effectively slowed the spread of COVID-19, they may have posed challenges to the well-being of residents.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This study aims to explore the effects of residential lockdown on the subjective well-being (SWB) of individuals in China during the COVID-19 pandemic.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>The sample consisted of 1790 Sina Weibo users who were residents of cities that imposed residential lockdowns, of which 1310 users (73.18%) were female, and 3580 users who were residents of cities that were not locked down (gender-matched with the 1790 lockdown residents). In both the lockdown and nonlockdown groups, we calculated SWB indicators during the 2 weeks before and after the enforcement date of the residential lockdown using individuals’ original posts on Sina Weibo. SWB was calculated via online ecological recognition, which is based on established machine learning predictive models.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>The interactions of time (before the residential lockdown or after the residential lockdown) × area (lockdown or nonlockdown) in the integral analysis (N=5370) showed that after the residential lockdown, compared with the nonlockdown group, the lockdown group scored lower in some negative SWB indicators, including somatization (<italic>F</italic><sub>1,5368</sub>=13.593, <italic>P</italic>&#60;.001) and paranoid ideation (<italic>F</italic><sub>1,5368</sub>=14.333, <italic>P</italic>&#60;.001). The interactions of time (before the residential lockdown or after the residential lockdown) × area (developed or underdeveloped) in the comparison of residential lockdown areas with different levels of economic development (N=1790) indicated that the SWB of residents in underdeveloped areas showed no significant change after the residential lockdown (<italic>P</italic>&#62;.05), while that of residents in developed areas changed.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>These findings increase our understanding of the psychological impact and cost of residential lockdown during an epidemic. The more negative changes in the SWB of residents in developed areas imply a greater need for psychological intervention under residential lockdown in such areas.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>COVID-19</kwd>
        <kwd>residential lockdown</kwd>
        <kwd>subjective well-being</kwd>
        <kwd>online ecological recognition</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <p>Since the outbreak of COVID-19, therapeutic options to treat the disease have been limited, although research to produce an effective and safe vaccine is quickly progressing. Varying degrees of travel limitations on citizens, such as residential lockdowns, were enforced across China to contain the epidemic. Residential lockdown is a type of home quarantine during which residents are not allowed to go out unnecessarily and each family can only appoint a relatively fixed family member to purchase living supplies every 2-3 days. These vigorous actions played a key role in containing the spread of COVID-19 [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref2">2</xref>]; however, they have also had some effects on residents’ mental health, including their subjective well-being (SWB) [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>]. In psychology, the concepts of well-being, mental health, and happiness are often used as synonyms [<xref ref-type="bibr" rid="ref5">5</xref>]. The World Health Organization (WHO) defined mental health as a “state of well-being whereby individuals recognize their abilities, are able to cope with the normal stresses of life, work productively and fruitfully, and make a contribution to their communities” [<xref ref-type="bibr" rid="ref6">6</xref>].</p>
      <p>As a comprehensive psychological indicator, SWB describes an individual’s subjective evaluation of their living quality and happiness [<xref ref-type="bibr" rid="ref7">7</xref>]. It focuses on personal experience in a specific social context to reflect individuals’ mental health [<xref ref-type="bibr" rid="ref8">8</xref>-<xref ref-type="bibr" rid="ref11">11</xref>]. As a social group experience [<xref ref-type="bibr" rid="ref11">11</xref>], SWB has also become a surveying mark of government action, governance capability, and social development trends [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref13">13</xref>]. During the COVID-19 crisis, the loss or significant reduction of SWB may not only increase the incidence of panic disorder, anxiety, depression, and other mental health issues [<xref ref-type="bibr" rid="ref14">14</xref>] but also cause a series of problems at the social level, such as social hindrance, unstable social environment, and decline of trust in the government [<xref ref-type="bibr" rid="ref15">15</xref>]. To adequately and effectively prepare for the psychological impact and cost of residential lockdown (eg, targeted psychological crisis intervention), it is necessary to examine the mental health of residents from the SWB perspective.</p>
      <p>At present, the assessment of positive SWB indicators mainly relies on self-report inventories such as the Psychological Well-Being (PWB) scale [<xref ref-type="bibr" rid="ref16">16</xref>]. In addition, because mental health is the crucial element or is even considered to be a synonym of SWB [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>], some psychiatric status rating scales are widely used to assess negative SWB indicators [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref18">18</xref>], such as the Symptom Checklist 90 (SCL-90), with good reliability and validity [<xref ref-type="bibr" rid="ref19">19</xref>-<xref ref-type="bibr" rid="ref21">21</xref>].</p>
      <p>However, it is almost impossible to conduct a SWB survey measuring the immediate psychological impact of residential lockdown without delay, as it is difficult to anticipate whether and when a residential lockdown will start, and a questionnaire cannot be used for ecological momentary assessment [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>]. On the other hand, retrospective measurement is also unsuitable for this aim because individuals’ recall bias may result in inability to accurately trace back to the original baseline state [<xref ref-type="bibr" rid="ref24">24</xref>]. Facing these challenges in conducting an accurate pre-post comparative analysis during unexpected residential lockdown, it is necessary to develop a new method to capture the SWB status of a large number of individuals in a timely fashion.</p>
      <p>With the rise of interdisciplinary research, information technology and computing models are increasingly being used in the evaluation of psychological characteristics, and the popularity of web-based social media provides a new platform for such research. Information collected from these social media platforms can clarify the public’s response and can be mapped to psychological indices [<xref ref-type="bibr" rid="ref25">25</xref>]. For example, Kosinski et al [<xref ref-type="bibr" rid="ref26">26</xref>] used digital records on Facebook to automatically and accurately predict users’ personal attributes. Qiu et al [<xref ref-type="bibr" rid="ref27">27</xref>] also showed that users’ personalities manifested on web-based social media. In China, Sina Weibo is a leading social media platform; by March 2020, it comprised more than 550 million monthly active users. By using machine learning–trained predictive models, users’ ecological behavior on Sina Weibo can be tracked to identify their psychological traits, such as their mental health status [<xref ref-type="bibr" rid="ref28">28</xref>]. Based on web-based big data, these prediction models provided a rationale for our research. According to previous studies, online ecological recognition (OER) can be defined as the method of acquiring users’ psychological characteristics by machine learning models based on ecological web-based social media data [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref30">30</xref>]. Therefore, in this study, to effectively examine the impact of the residential lockdown on SWB, we conducted OER on publicly available Sina Weibo data to identify users’ SWB with high ecological validity on a large scale.</p>
      <p>In the present study, we aimed to explore the impact of the residential lockdown on SWB of individuals during the COVID-19 pandemic. To examine individuals’ SWB before and after the residential lockdown, we used data from posts by active Sina Weibo users to calculate SWB indicators through OER based on trained predictive models [<xref ref-type="bibr" rid="ref5">5</xref>]. The main purpose of this study was to obtain empirical evidence to provide deep insight into the psychological impact and cost of the residential lockdown. This will in turn form the basis for a concrete plan to develop and implement targeted intervention policies to cope with the COVID-19 pandemic efficiently and effectively.</p>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Sampling</title>
        <p>We searched for the following keywords on Baidu (baidu.com): <italic>residential lockdown</italic> (居民出行管控) + <italic>city</italic> or <italic>211 measure</italic> (211举措; the abbreviation of the residential lockdown policy) + <italic>city</italic>. After locating the cities that had issued residential lockdowns from January 20 to February 20, 2020, we finally obtained 17 prefecture-level cities in which local governments implemented the same residential lockdown policy. Then, we identified the specific time period for the implementation of the residential lockdown from the announcement released by the local COVID-19 Prevention and Control Headquarters, and we took the enforcement date as the demarcation point of this study. The residential lockdown cities and the enforcement and ending dates of their residential lockdowns are shown in <xref ref-type="table" rid="table1">Table 1</xref>. Given that the lockdown enforcement durations of Ningbo, Taizhou, and Yiwu were all &#60;2 weeks, we excluded these three residential lockdown cities from the subsequent analysis.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Residential lockdown cities and their enforcement and ending dates (in 2020).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="200"/>
            <col width="400"/>
            <col width="200"/>
            <col width="200"/>
            <thead>
              <tr valign="top">
                <td>Residential lockdown city</td>
                <td>Province</td>
                <td>Enforcement date</td>
                <td>Ending date</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Bengbu</td>
                <td>Anhui</td>
                <td>February 3</td>
                <td>March 22</td>
              </tr>
              <tr valign="top">
                <td>Ezhou</td>
                <td>Hubei</td>
                <td>February 4</td>
                <td>March 25</td>
              </tr>
              <tr valign="top">
                <td>Fangchenggang</td>
                <td>Guangxi Zhuang Autonomous Region</td>
                <td>February 2</td>
                <td>March 6</td>
              </tr>
              <tr valign="top">
                <td>Fuyang</td>
                <td>Anhui</td>
                <td>February 5</td>
                <td>March 9</td>
              </tr>
              <tr valign="top">
                <td>Guigang</td>
                <td>Guangxi Zhuang Autonomous Region</td>
                <td>February 3</td>
                <td>February 24</td>
              </tr>
              <tr valign="top">
                <td>Huaibei</td>
                <td>Anhui</td>
                <td>February 3</td>
                <td>March 20</td>
              </tr>
              <tr valign="top">
                <td>Huanggang</td>
                <td>Hubei</td>
                <td>February 1</td>
                <td>March 22</td>
              </tr>
              <tr valign="top">
                <td>Huangshi</td>
                <td>Hubei</td>
                <td>February 17</td>
                <td>March 23</td>
              </tr>
              <tr valign="top">
                <td>Nanyang</td>
                <td>Henan</td>
                <td>February 4</td>
                <td>March 11</td>
              </tr>
              <tr valign="top">
                <td>Ningbo<sup>a</sup></td>
                <td>Zhejiang</td>
                <td>February 4</td>
                <td>February 10</td>
              </tr>
              <tr valign="top">
                <td>Songyuan</td>
                <td>Jilin</td>
                <td>February 4</td>
                <td>March 20</td>
              </tr>
              <tr valign="top">
                <td>Taizhou<sup>a</sup></td>
                <td>Zhejiang</td>
                <td>February 2</td>
                <td>February 13</td>
              </tr>
              <tr valign="top">
                <td>Wenzhou</td>
                <td>Zhejiang</td>
                <td>February 1</td>
                <td>February 19</td>
              </tr>
              <tr valign="top">
                <td>Wuhan</td>
                <td>Hubei</td>
                <td>February 11</td>
                <td>April 8</td>
              </tr>
              <tr valign="top">
                <td>Xiaogan</td>
                <td>Hubei</td>
                <td>February 14</td>
                <td>March 14</td>
              </tr>
              <tr valign="top">
                <td>Yiwu<sup>a</sup></td>
                <td>Zhejiang</td>
                <td>February 4</td>
                <td>February 12</td>
              </tr>
              <tr valign="top">
                <td>Zhongshan</td>
                <td>Guangdong</td>
                <td>February 7</td>
                <td>March 27</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>q</sup>Ningbo, Taizhou, and Yiwu were not included in subsequent analyses because the enforcement duration in these cities was less than 2 weeks.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Participants and Data Collection</title>
        <p>The sample in this study was obtained from the original Sina Weibo data pool [<xref ref-type="bibr" rid="ref30">30</xref>] containing more than 1.16 million active users. The retrieved data included users’ account profiles and posts. Privacy was strictly protected during this process, referring to the ethical principles listed by Kosinski et al [<xref ref-type="bibr" rid="ref31">31</xref>]. This study was approved by the Review Board of Institute of Psychology, Chinese Academy of Sciences (ethical code H15009).</p>
        <p>From the data pool, we selected Sina Weibo users who met the following criteria: (1) Published at least one original Weibo post per day on average within 2 weeks before and after the corresponding enforcement date of the residential lockdown (see <xref ref-type="table" rid="table2">Table 2</xref>); (2) authentication type was no-institutional, such as individual user; (3) the geolocation of the user’s account profile was in China, not “overseas” or “others.”</p>
        <sec>
          <title>Lockdown Group</title>
          <p>We combined all the residential lockdown cities mentioned in <xref ref-type="table" rid="table1">Table 1</xref> except Ningbo, Taizhou, and Yiwu as the lockdown group. Then, we downloaded each user’s original posts during the 2 weeks before and after the enforcement date of the residential lockdown in their city of residence for analysis in this study.</p>
        </sec>
        <sec>
          <title>Nonlockdown Group</title>
          <p>We combined users who did not live in the abovementioned 17 residential lockdown cities as the entire nonlockdown sample group. Because cities under residential lockdown are a minority among all the cities in China, to increase the generalizability of the results and reduce sampling error, we built the nonlockdown group at twice the sample size of the lockdown group in each of the 14 residential lockdown cities by random sampling without replacement of users in the whole nonlockdown sample group. The male-female ratio of the nonlockdown group was same as that of the lockdown group. Finally, we downloaded each user’s original posts during the 2 weeks before and after the enforcement date from the paired residential lockdown city for analysis in this study.</p>
          <p>The final sample contained 5370 users, among whom the male-female ratio was 1:2.7 (see <xref ref-type="table" rid="table2">Table 2</xref> for details).</p>
          <table-wrap position="float" id="table2">
            <label>Table 2</label>
            <caption>
              <p>Numbers of users in each group in the final sample and corresponding time periods of data extraction (N=5370).</p>
            </caption>
            <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
              <col width="200"/>
              <col width="220"/>
              <col width="220"/>
              <col width="180"/>
              <col width="180"/>
              <thead>
                <tr valign="top">
                  <td>Residential lockdown city</td>
                  <td colspan="2">Time period (in 2020)</td>
                  <td>Lockdown group</td>
                  <td>Nonlockdown group</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Before the residential lockdown</td>
                  <td>After the residential lockdown</td>
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                </tr>
              </thead>
              <tbody>
                <tr valign="top">
                  <td>Bengbu</td>
                  <td>January 21 to February 3</td>
                  <td>February 4-17</td>
                  <td>25</td>
                  <td>50</td>
                </tr>
                <tr valign="top">
                  <td>Ezhou</td>
                  <td>January 21 to February 3</td>
                  <td>February 4-17</td>
                  <td>16</td>
                  <td>32</td>
                </tr>
                <tr valign="top">
                  <td>Fangchenggang</td>
                  <td>January 19 to February 1</td>
                  <td>February 2-15</td>
                  <td>18</td>
                  <td>36</td>
                </tr>
                <tr valign="top">
                  <td>Fuyang</td>
                  <td>January 22 to February 4</td>
                  <td>February 5-18</td>
                  <td>14</td>
                  <td>28</td>
                </tr>
                <tr valign="top">
                  <td>Guigang</td>
                  <td>January 20 to February 2</td>
                  <td>February 3-16</td>
                  <td>32</td>
                  <td>64</td>
                </tr>
                <tr valign="top">
                  <td>Huaibei</td>
                  <td>January 20 to February 2</td>
                  <td>February 3-16</td>
                  <td>25</td>
                  <td>50</td>
                </tr>
                <tr valign="top">
                  <td>Huanggang</td>
                  <td>January 18-31</td>
                  <td>February 1-14</td>
                  <td>28</td>
                  <td>56</td>
                </tr>
                <tr valign="top">
                  <td>Huangshi</td>
                  <td>February 3-16</td>
                  <td>February 17 to March 1</td>
                  <td>11</td>
                  <td>22</td>
                </tr>
                <tr valign="top">
                  <td>Nanyang</td>
                  <td>January 21 to February 3</td>
                  <td>February 4-17</td>
                  <td>42</td>
                  <td>84</td>
                </tr>
                <tr valign="top">
                  <td>Songyuan</td>
                  <td>January 21 to February 3</td>
                  <td>February 4-17</td>
                  <td>16</td>
                  <td>32</td>
                </tr>
                <tr valign="top">
                  <td>Wenzhou</td>
                  <td>January 19 to February 1</td>
                  <td>February 2-15</td>
                  <td>235</td>
                  <td>470</td>
                </tr>
                <tr valign="top">
                  <td>Wuhan</td>
                  <td>January 28 to February 10</td>
                  <td>February 11-24</td>
                  <td>1084</td>
                  <td>2168</td>
                </tr>
                <tr valign="top">
                  <td>Xiaogan</td>
                  <td>January 31 to February 13</td>
                  <td>February 14-27</td>
                  <td>10</td>
                  <td>20</td>
                </tr>
                <tr valign="top">
                  <td>Zhongshan</td>
                  <td>January 24 to February 6</td>
                  <td>February 7-20</td>
                  <td>234</td>
                  <td>468</td>
                </tr>
              </tbody>
            </table>
          </table-wrap>
        </sec>
      </sec>
      <sec>
        <title>Compartmentalization by Economic Development Level</title>
        <p>SWB is influenced by various factors in the long term [<xref ref-type="bibr" rid="ref32">32</xref>-<xref ref-type="bibr" rid="ref35">35</xref>], and there is an inevitable connection between the level of economic development and SWB. Clark and Senik [<xref ref-type="bibr" rid="ref36">36</xref>] reported that economic development was generally identified with growth in gross domestic product (GDP) per capita, which improved residents’ welfare [<xref ref-type="bibr" rid="ref37">37</xref>]. Therefore, differentiating the lockdown group by GDP per capita could clarify the impact of the residential lockdown under different economic development conditions.</p>
        <p>We took the GDP per capita published by the Municipal Bureau of Statistics of each residential lockdown city in 2017 as the indicator of economic development level. Using between-groups linkage and taking the squared Euclidean distance as the measurement standard, we applied a hierarchical clustering analysis on the 14 residential lockdown cities included in our study. The dendrogram of the whole process of clustering indicated that when the 14 residential lockdown cities were divided into 2 categories, the distance between the categories was relatively large and the characteristics of each category were relatively prominent; therefore, the categories could be readily defined. We applied an additional hierarchical clustering analysis with a cluster number of 2 on the 14 residential lockdown cities. The results suggested that the first category included Wuhan, Ezhou, Zhongshan, and Fangchenggang, and the second category included the remaining 10 residential lockdown cities. Based on this result, in this study, we grouped Wuhan, Ezhou, Zhongshan, and Fangchenggang into developed areas with residential lockdowns and grouped the remaining 10 residential lockdown cities into underdeveloped areas with residential lockdowns. All analyses were performed using SPSS Statistics 26 (IBM Corporation).</p>
      </sec>
      <sec>
        <title>Measurement of SWB and Procedure</title>
        <p>We applied OER by employing established machine learning models [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref38">38</xref>] to calculate the SWB indicators of the users in the final sample before and after the corresponding enforcement date of the residential lockdown. First, we used the TextMind system [<xref ref-type="bibr" rid="ref39">39</xref>], a Chinese language psychological analysis system, to extract psycholinguistic features from active Sina Weibo users’ original posts. This system first segmented the users’ original Weibo posts and extracted independent and linguistically labeled words [<xref ref-type="bibr" rid="ref40">40</xref>]; then, it used the Simplified Chinese Language Inquiry and Word Count (SCLIWC) to determine the word frequency statistics [<xref ref-type="bibr" rid="ref41">41</xref>].</p>
        <p>Next, we used these extracted psycholinguistic features as the input of established machine learning models to calculate the SWB indicators. The SWB indicators in our research included both positive and negative indicators, which are depicted in <xref ref-type="table" rid="table3">Table 3</xref>. Because the SCL-90 is also widely used in the assessment of negative SWB indicators [<xref ref-type="bibr" rid="ref17">17</xref>], we used factors of the SCL-90 as our negative SWB indicators.</p>
        <table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Positive and negative SWB indicators.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="370"/>
            <col width="600"/>
            <thead>
              <tr valign="top">
                <td colspan="2">SWB<sup>a</sup> indicator</td>
                <td>Definition</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="3">
                  <bold>Positive<sup>b</sup></bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Self-acceptance</td>
                <td>Possession of a positive attitude toward the self</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Environmental mastery</td>
                <td>Sense of mastery and competence in managing the environment</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Positive relations</td>
                <td>Warm, satisfying, trusting relationships with others</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Purpose in life</td>
                <td>Goals in life and a sense of directedness</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Personal growth</td>
                <td>Feeling of continued development</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Autonomy</td>
                <td>Self-determining and independent</td>
              </tr>
              <tr valign="top">
                <td colspan="3">
                  <bold>Negative<sup>c</sup></bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Somatization</td>
                <td>Distress arising from perceptions of bodily disfunction</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Obsessive-compulsive</td>
                <td>Thoughts, impulses, and actions that are experienced as unremitting and irresistible by the individual, but are of an ego-alien or unwanted nature</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Interpersonal sensitivity</td>
                <td>Feelings of personal inadequacy and inferiority, particularly in comparison to other persons</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Depression</td>
                <td>Withdrawal of life interest, lack of motivation, and loss of vital energy</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Anxiety</td>
                <td>Restlessness, nervousness, and tension</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Hostility</td>
                <td>Thoughts, feelings, or actions that are characteristics of the negative affect state of anger</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Phobic anxiety</td>
                <td>Persistent fear response to a specific person, place, object, or situation which is characterized as being irrational and disproportionate to the stimulus, and which leads to avoidance or escape behavior</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Paranoid Ideation</td>
                <td>Paranoid behavior fundamentally as a disordered mode of thinking</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Psychoticism</td>
                <td>Withdrawn, isolated, schizoid lifestyle, and first-rank symptoms of schizophrenia.</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table3fn1">
              <p><sup>a</sup>SWB: subjective well-being.</p>
            </fn>
            <fn id="table3fn2">
              <p><sup>b</sup>Source: Psychological Well-Being scale [<xref ref-type="bibr" rid="ref42">42</xref>].</p>
            </fn>
            <fn id="table3fn3">
              <p><sup>c</sup>Source: Symptom Checklist 90 [<xref ref-type="bibr" rid="ref19">19</xref>].</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <p>We used Li, Hao, Bai, and Zhu’s machine learning model [<xref ref-type="bibr" rid="ref28">28</xref>] to calculate the positive SWB indicators. To establish this predictive model, 1785 active Sina Weibo users were invited to complete Scales of PWB on the internet [<xref ref-type="bibr" rid="ref42">42</xref>] and were asked for approval to access their Weibo data. Then, we used multivariate adaptive regression splines and other algorithms to fit the relationship between the psycholinguistic features and self-report scores, and the evaluation was conducted by 10-fold cross-validation. To predict the negative SWB indicators, we used Hao et al’s [<xref ref-type="bibr" rid="ref38">38</xref>] machine-learning model to predict them. To establish this model, we used Weibo data of 448 active Sina Weibo users and their SCL-90 scores [<xref ref-type="bibr" rid="ref19">19</xref>]. We used a linear regression algorithm to fit the relationship between the psycholinguistic features and self-report scores and conducted 10-fold cross-validation. For most SWB indicators, the Pearson correlation coefficient between the predicted and self-report scores achieved a moderate level (≥.30) [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref38">38</xref>]. For more details about the established SWB models, please see [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref38">38</xref>].</p>
        <p>To explore the overall impact of the residential lockdown on SWB, we conducted 2 (times: before the residential lockdown, after the residential lockdown) × 2 (areas: lockdown, nonlockdown) repeated measures analysis of variance (RM ANOVA) on all our samples. In this analysis, time was the within-subject factor, while area was the between-subject factor. Moreover, to explore the impact of the residential lockdown on the SWB of residents at different economic development levels, we applied 2 (times: before the residential lockdown, after the residential lockdown) × 2 (areas: developed, underdeveloped) RM ANOVA on the residential lockdown cities. All these analyses were performed using SPSS 26.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Demographics</title>
        <p>Among the 5370 active Sina Weibo users, 1790 were in the lockdown group (1310 female, 73.18%) and 3580 were in the non-lockdown group (gender matched with the lockdown group). According to the birthdates the users registered in their account profiles (1160/5370, 21.60%), the users’ ages ranged from 21 to 83 years, with a median age of 29.95 (SD 6.30) years. <xref ref-type="table" rid="table4">Table 4</xref> features the demographic profiles of these users.</p>
        <table-wrap position="float" id="table4">
          <label>Table 4</label>
          <caption>
            <p>Demographic characteristics of users in the lockdown group and nonlockdown group (N=5370), n (%).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="120"/>
            <col width="250"/>
            <col width="220"/>
            <col width="200"/>
            <col width="180"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Characteristic</td>
                <td>Developed areas with residential lockdown (n=1352)</td>
                <td>Underdeveloped areas with residential lockdown (n=438)</td>
                <td>Lockdown group (n<italic>=</italic>1790)</td>
                <td>Nonlockdown group (n<italic>=</italic>3580)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="6">
                  <bold>Gender</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Male</td>
                <td>348 (25.74)</td>
                <td>132 (30.14)</td>
                <td>480 (26.82)</td>
                <td>960 (26.82)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Female</td>
                <td>1004 (74.26)</td>
                <td>306 (69.86)</td>
                <td>1310 (73.18)</td>
                <td>2620 (73.18)</td>
              </tr>
              <tr valign="top">
                <td colspan="6">
                  <bold>Age (years)</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>18-30</td>
                <td>198 (14.64)</td>
                <td>57 (13.01)</td>
                <td>255 (14.25)</td>
                <td>464 (12.96)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>31-40</td>
                <td>92 (6.80)</td>
                <td>36 (8.22)</td>
                <td>128 (7.15)</td>
                <td>249 (6.96)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>≥41</td>
                <td>11 (0.81)</td>
                <td>7 (1.60)</td>
                <td>18 (1.01)</td>
                <td>46 (1.28)</td>
              </tr>
              <tr valign="top">
                <td colspan="2">Missing data</td>
                <td>1051 (77.74)</td>
                <td>338 (77.17)</td>
                <td>1389 (77.60)</td>
                <td>2821 (78.80)</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
      <sec>
        <title>All Residential Lockdown Cities</title>
        <p>In this analysis, we compared the SWB scores of residents of different areas across the country during different periods. As shown in <xref ref-type="table" rid="table5">Table 5</xref>, there were significant (including marginally significant) interactions of area and time on 2 negative SWB indicators.</p>
        <table-wrap position="float" id="table5">
          <label>Table 5</label>
          <caption>
            <p>Repeated measures analysis of variance on subjective well-being across China.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="160"/>
            <col width="90"/>
            <col width="90"/>
            <col width="90"/>
            <col width="90"/>
            <col width="80"/>
            <col width="80"/>
            <col width="80"/>
            <col width="80"/>
            <col width="80"/>
            <col width="80"/>
            <thead>
              <tr valign="top">
                <td>Indicator</td>
                <td colspan="4">Residential lockdown area, mean (SD)</td>
                <td colspan="2">Area</td>
                <td colspan="2">Time</td>
                <td colspan="2">Area × Time</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="2">Lockdown group (n=1790)</td>
                <td colspan="2">Nonlockdown group (n=3580)</td>
                <td>
                  <italic>F<sub>1,5368</sub></italic>
                </td>
                <td><italic>P</italic> value</td>
                <td>
                  <italic>F<sub>1,5368</sub></italic>
                </td>
                <td><italic>P</italic> value</td>
                <td>
                  <italic>F<sub>1,5368</sub></italic>
                </td>
                <td><italic>P</italic> value</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>T-before<sup>a</sup></td>
                <td>T-after<sup>b</sup></td>
                <td>T-before</td>
                <td>T-after</td>
                <td colspan="6">
                  <break/>
                </td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Somatization</td>
                <td>8.38 (2.94)</td>
                <td>8.64 (3.04)</td>
                <td>8.56 (3.25)</td>
                <td>8.98 (3.30)</td>
                <td>10.457</td>
                <td>.001</td>
                <td>56.414</td>
                <td>&#60;.001</td>
                <td>3.430</td>
                <td>.06</td>
              </tr>
              <tr valign="top">
                <td>Paranoid Ideation</td>
                <td>5.46 (1.46)</td>
                <td>5.61 (1.45)</td>
                <td>5.58 (1.85)</td>
                <td>5.82 (2.11)</td>
                <td>12.418</td>
                <td>&#60;.001</td>
                <td>66.862</td>
                <td>&#60;.001</td>
                <td>3.405</td>
                <td>.07</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table5fn1">
              <p><sup>a</sup>T-before: the period before the residential lockdown.</p>
            </fn>
            <fn id="table5fn2">
              <p><sup>b</sup>T-after: the period after the residential lockdown.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <sec>
          <title>Somatization</title>
          <p>The main effect of the area was significant (<italic>F</italic><sub>1,5368</sub>=10.457, <italic>P</italic>=.001, η<sub>p</sub><sup>2</sup>=0.002). The main effect of time was significant (<italic>F</italic><sub>1,5368</sub>=56.414, <italic>P</italic>&#60;.001, η<sub>p</sub><sup>2</sup>=0.010. The interaction of area and time was marginally significant (<italic>F</italic><sub>1,5368</sub>=3.430, <italic>P</italic>=.06, η<sub>p</sub><sup>2</sup>=0.001. After simple effect analysis, our findings were as follows:</p>
          <p>Area: In the T-before period, there was no significant difference between the lockdown group and the nonlockdown group; in the T-after period, the somatization of residents in the lockdown group was significantly lower than that of residents in the non-lockdown group (<italic>F</italic><sub>1,5368</sub>=13.593, <italic>P</italic>&#60;.001, η<sub>p</sub><sup>2</sup>=0.003).</p>
          <p>Time: After the implementation of the residential lockdown, somatization of the residents in both groups increased significantly (lockdown group: <italic>F</italic><sub>1,5368</sub>=12.009, <italic>P</italic>=.001, η<sub>p</sub><sup>2</sup>=0.002; nonlockdown group: <italic>F</italic><sub>1,5368</sub>=65.748, <italic>P</italic>&#60;.001, η<sub>p</sub><sup>2</sup>=0.012).</p>
        </sec>
        <sec>
          <title>Paranoid Ideation</title>
          <p>The main effect of area was significant (<italic>F</italic><sub>1,5368</sub>=12.418, <italic>P</italic>&#60;.001, η<sub>p</sub><sup>2</sup><italic>=</italic>0.002). The main effect of time was significant (<italic>F</italic><sub>1,5368</sub>=66.862, <italic>P</italic>&#60;.001, η<sub>p</sub><sup>2</sup>=0.012). The interaction of area and time was marginally significant (<italic>F</italic><sub>1,5368</sub>=3.405, <italic>P</italic>=.07, η<sub>p</sub><sup>2</sup>=0.001). After simple effect analysis, our findings were as follows:</p>
          <p>Area: In both periods, the paranoid ideation of residents in the lockdown group was significantly lower than that of residents in the nonlockdown group (T-before: <italic>F</italic><sub>1,5368</sub>=6.008, <italic>P</italic>=.01, η<sub>p</sub><sup>2</sup>=0.001; T-after: <italic>F</italic><sub>1,5368</sub>=14.333, <italic>P</italic>&#60;.001, η<sub>p</sub><sup>2</sup>=0.003).</p>
          <p>Time: After the implementation of the residential lockdown, the paranoid ideation of residents in both groups increased significantly (lockdown group: <italic>F</italic><sub>1,5368</sub>=15.033, <italic>P</italic>&#60;.001, η<sub>p</sub><sup>2</sup>=0.003; non-lockdown group: <italic>F</italic><sub>1,5368</sub>=75.334, <italic>P</italic>&#60;.001, η<sub>p</sub><sup>2</sup>=0.014).</p>
          <p>However, for self-acceptance, environmental mastery, positive relations, purpose in life, personal growth, autonomy, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, and psychoticism, the interactions of area and time were not significant (all <italic>P</italic> values &#62;.10).</p>
          <p>The interactions of somatization and paranoid ideation are presented in <xref rid="figure1" ref-type="fig">Figure 1</xref>.</p>
          <fig id="figure1" position="float">
            <label>Figure 1</label>
            <caption>
              <p>Interactions of area and time on (a) somatization and (b) paranoid ideation across China. T-after: the period after the residential lockdown; T-before: the period before the residential lockdown.</p>
            </caption>
            <graphic xlink:href="jmir_v22i12e24775_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
      </sec>
      <sec>
        <title>Residential Lockdown Areas at Different Economic Development Levels</title>
        <p>According to the clustering analysis above, we grouped Wuhan, Ezhou, Zhongshan, and Fangchenggang into developed areas with residential lockdowns, and we grouped the remaining 10 residential lockdown cities into underdeveloped areas with residential lockdowns. To further explore the different effects of residential lockdown on the SWB of residents of areas with different economic development, we compared the SWB scores of residents of developed areas and underdeveloped areas during the different periods.</p>
        <p>As shown in <xref ref-type="table" rid="table6">Table 6</xref>, there were significant (including marginally significant) interactions of area and time on 2 positive SWB indicators and 5 negative SWB indicators.</p>
        <table-wrap position="float" id="table6">
          <label>Table 6</label>
          <caption>
            <p>Repeated measures analysis of variance on subjective well-being in the residential lockdown areas.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="180"/>
            <col width="100"/>
            <col width="100"/>
            <col width="100"/>
            <col width="100"/>
            <col width="70"/>
            <col width="70"/>
            <col width="70"/>
            <col width="70"/>
            <col width="70"/>
            <col width="70"/>
            <thead>
              <tr valign="top">
                <td>Indicator</td>
                <td colspan="4">Residential lockdown area, mean (SD)</td>
                <td colspan="2">Area</td>
                <td colspan="2">Time</td>
                <td colspan="2">Area × Time</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="2">Developed (n=1352)</td>
                <td colspan="2">Underdeveloped (n=438)</td>
                <td>
                  <italic>F<sub>1,1788</sub></italic>
                </td>
                <td><italic>P</italic> value</td>
                <td>
                  <italic>F<sub>1,1788</sub></italic>
                </td>
                <td><italic>P</italic> value</td>
                <td>
                  <italic>F<sub>1,1788</sub></italic>
                </td>
                <td><italic>P</italic> value</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>T-before<sup>a</sup></td>
                <td>T-after<sup>b</sup></td>
                <td>T-before</td>
                <td>T-after</td>
                <td colspan="6">
                  <break/>
                </td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Purpose in life</td>
                <td>12.19 (1.23)<break/></td>
                <td>12.14 (1.30)</td>
                <td>11.96 (1.20)</td>
                <td>12.08 (1.53)</td>
                <td>5.548</td>
                <td>.02</td>
                <td>0.698</td>
                <td>.40</td>
                <td>5.057</td>
                <td>.03</td>
              </tr>
              <tr valign="top">
                <td>Autonomy</td>
                <td>10.92 (1.81)<break/></td>
                <td>10.84 (1.75)</td>
                <td>10.57 (1.85)</td>
                <td>10.67 (1.79)</td>
                <td>8.351</td>
                <td>.004</td>
                <td>0.099</td>
                <td>.75</td>
                <td>4.984</td>
                <td>.03</td>
              </tr>
              <tr valign="top">
                <td>Interpersonal sensitivity</td>
                <td>9.31 (2.73)<break/></td>
                <td>9.55 (2.74)</td>
                <td>9.81 (2.97)</td>
                <td>9.63 (2.96)</td>
                <td>4.342</td>
                <td>.04</td>
                <td>0.248</td>
                <td>.62</td>
                <td>9.850</td>
                <td>.002</td>
              </tr>
              <tr valign="top">
                <td>Anxiety</td>
                <td>9.48±3.85<break/></td>
                <td>9.99±4.16</td>
                <td>10.00 (3.95)</td>
                <td>10.04±4.42</td>
                <td>1.880</td>
                <td>.17</td>
                <td>9.527</td>
                <td>.002</td>
                <td>7.273</td>
                <td>.007</td>
              </tr>
              <tr valign="top">
                <td>Hostility</td>
                <td>5.44 (2.00)<break/></td>
                <td>5.60 (2.08)</td>
                <td>5.75 (2.22)</td>
                <td>5.66 (2.13)</td>
                <td>3.382</td>
                <td>.07</td>
                <td>0.466</td>
                <td>.50</td>
                <td>5.202</td>
                <td>.02</td>
              </tr>
              <tr valign="top">
                <td>Paranoid ideation</td>
                <td>5.43 (1.42)</td>
                <td>5.61 (1.45)</td>
                <td>5.57 (1.55)</td>
                <td>5.61 (1.47)</td>
                <td>1.155</td>
                <td>.28</td>
                <td>7.822</td>
                <td>.005</td>
                <td>3.083</td>
                <td>.08</td>
              </tr>
              <tr valign="top">
                <td>Psychoticism</td>
                <td>8.63 (2.55)<break/></td>
                <td>8.84 (2.83)</td>
                <td>9.03 (2.89)</td>
                <td>8.97 (2.69)</td>
                <td>4.251</td>
                <td>.04</td>
                <td>1.074</td>
                <td>.30</td>
                <td>3.584</td>
                <td>.06</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table6fn1">
              <p><sup>a</sup>T-before: the period before the residential lockdown.</p>
            </fn>
            <fn id="table6fn2">
              <p><sup>b</sup>T-after: the period after the residential lockdown.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <sec>
          <title>Purpose in Life</title>
          <p>The main effect of area was significant (<italic>F</italic><sub>1,1788</sub>=5.548, <italic>P</italic>=.02, η<sub>p</sub><sup>2</sup>=0.003). The main effect of time was not significant (<italic>F</italic><sub>1,1788</sub>=0.698, <italic>P</italic>=.40, η<sub>p</sub><sup>2</sup>=0.000). The interaction of area and time was significant (<italic>F</italic><sub>1,1788</sub>=5.057, <italic>P</italic>=.03, η<sub>p</sub><sup>2</sup>=0.003). After simple effect analysis, our findings were as follows:</p>
          <p>Area: In the T-before period, the purpose in life of residents of developed areas with residential lockdowns was significantly higher than that of residents of underdeveloped areas with residential lockdowns (<italic>F</italic><sub>1,1788</sub>=11.363, <italic>P</italic>=.001, η<sub>p</sub><sup>2</sup>=0.006); in the T-after period, there was no significant difference between developed and underdeveloped areas with residential lockdowns.</p>
          <p>Time: After the implementation of the residential lockdown, there were no significant changes in either developed or underdeveloped areas with residential lockdowns.</p>
        </sec>
        <sec>
          <title>Autonomy</title>
          <p>The main effect of area was significant (<italic>F</italic><sub>1,1788</sub>=8.351, <italic>P</italic>=.004, η<sub>p</sub><sup>2</sup>=0.005). The main effect of time was not significant (<italic>F</italic><sub>1,1788</sub>=.099, <italic>P</italic>=.75, η<sub>p</sub><sup>2</sup>=0.000). The interaction of area and time was significant (<italic>F</italic><sub>1,1788</sub>=4.984, <italic>P</italic>=.03, η<sub>p</sub><sup>2</sup>=0.003). After simple effect analysis, our findings were as follows:</p>
          <p>Area: In the T-before period, the autonomy of residents of developed areas with residential lockdowns was significantly higher than that of residents of under-developed areas with residential lockdowns (<italic>F</italic><sub>1,1788</sub>=12.229, <italic>P</italic>&#60;.001, η<sub>p</sub><sup>2</sup>=0.007; in the T-after period, there was no significant difference between developed and underdeveloped areas with residential lockdown.</p>
          <p>Time: After the implementation of residential lockdown, there were no significant changes in either developed or underdeveloped areas with residential lockdowns.</p>
        </sec>
        <sec>
          <title>Interpersonal Sensitivity</title>
          <p>The main effect of area was significant (<italic>F</italic><sub>1,1788</sub>=4.342, <italic>P</italic>=.04, η<sub>p</sub><sup>2</sup>=0.002). The main effect of time was not significant (<italic>F</italic><sub>1,1788</sub>=0.248, <italic>P</italic>=.62, η<sub>p</sub><sup>2</sup>=0.000). The interaction of area and time was significant (<italic>F</italic><sub>1,1788</sub>= 9.850, <italic>P</italic>=.002, η<sub>p</sub><sup>2</sup>=0.005). After simple effect analysis, our findings were as follows:</p>
          <p>Area: In the T-before period, the interpersonal sensitivity of residents of developed areas with residential lockdowns was significantly lower than that of residents of underdeveloped areas with residential lockdowns (<italic>F</italic><sub>1,1788</sub>=10.643, <italic>P</italic>=.001, η<sub>p</sub><sup>2</sup>=0.006); in the T-after period, there was no significant difference between developed and underdeveloped areas with residential lockdowns.</p>
          <p>Time: After the implementation of residential lockdown, the interpersonal sensitivity of residents in developed areas with residential lockdowns increased significantly (<italic>F</italic><sub>1,1788</sub>=13.514, <italic>P</italic>&#60;.001, η<sub>p</sub><sup>2</sup>=0.008); meanwhile, there was no significant change in underdeveloped areas with residential lockdowns.</p>
        </sec>
        <sec>
          <title>Anxiety</title>
          <p>The main effect of area was not significant (<italic>F</italic><sub>1,1788</sub>=1.880, <italic>P</italic>=.17, η<sub>p</sub><sup>2</sup>=0.001). The main effect of time was significant (<italic>F</italic><sub>1,1788</sub>=9.527, <italic>P</italic>=.002, η<sub>p</sub><sup>2</sup>=0.005). The interaction of area and time was significant (<italic>F</italic><sub>1,1788</sub>=7.273, <italic>P</italic>=.007, η<sub>p</sub><sup>2</sup>=0.004). After simple effect analysis, our findings were as follows:</p>
          <p>Area: In the T-before period, the anxiety of residents of developed areas with residential lockdowns was significantly lower than that of residents of underdeveloped areas with residential lockdowns (<italic>F</italic><sub>1,1788</sub>=5.923, <italic>P</italic>=.02, η<sub>p</sub><sup>2</sup>=0.003); in the T-after period, there was no significant difference between developed and underdeveloped areas with residential lockdowns.</p>
          <p>Time: After the implementation of residential lockdown, the anxiety of residents of developed areas with residential lockdowns increased significantly (<italic>F</italic><sub>1,1788</sub>=34.173, <italic>P</italic>&#60;.001, η<sub>p</sub><sup>2</sup>=.019); meanwhile, there was no significant change in underdeveloped areas with residential lockdowns.</p>
        </sec>
        <sec>
          <title>Hostility</title>
          <p>The main effect of area was marginally significant (<italic>F</italic><sub>1,1788</sub>=3.382, <italic>P</italic>=.07, η<sub>p</sub><sup>2</sup>=0.002). The main effect of time was not significant (<italic>F</italic><sub>1,1788</sub>=0.466, <italic>P</italic>=.50, η<sub>p</sub><sup>2</sup>=0.000). The interaction of area and time was significant (<italic>F</italic><sub>1,1788</sub>=5.202, <italic>P</italic>=.02, η<sub>p</sub><sup>2</sup>=0.003). After simple effect analysis, our findings were as follows:</p>
          <p>Area: In the T-before period, the hostility of residents of developed areas with residential lockdowns was significantly lower than that of residents of underdeveloped areas with residential lockdowns (<italic>F</italic><sub>1,1788</sub>=7.487, <italic>P</italic>=.006, η<sub>p</sub><sup>2</sup>=0.004); in the T-after period, there was no significant difference between developed and underdeveloped areas with residential lockdowns.</p>
          <p>Time: After the implementation of residential lockdown, the hostility of residents of developed areas with residential lockdowns increased significantly (<italic>F</italic><sub>1,1788</sub>=8.974, <italic>P</italic>=.003, η<sub>p</sub><sup>2</sup>=0.005); meanwhile, there was no significant change in underdeveloped areas with residential lockdowns.</p>
        </sec>
        <sec>
          <title>Paranoid Ideation</title>
          <p>The main effect of area was not significant (<italic>F</italic><sub>1,1788</sub>=1.155, <italic>P</italic>=.28, η<sub>p</sub><sup>2</sup>=0.001). The main effect of time was significant (<italic>F</italic><sub>1,1788</sub>=7.822, <italic>P</italic>=.005, η<sub>p</sub><sup>2</sup>=0.004). The interaction of area and time was marginally significant (<italic>F</italic><sub>1,1788</sub>=3.083, <italic>P</italic>=.08, η<sub>p</sub><sup>2</sup>=0.002). After simple effect analysis, our findings were as follows:</p>
          <p>Area: In both periods, there were no significant differences between developed and underdeveloped areas with residential lockdowns.</p>
          <p>Time: After the implementation of residential lockdown, the paranoid ideation of residents of developed areas with residential lockdowns increased significantly (<italic>F</italic><sub>1,1788</sub>=21.177, <italic>P</italic>&#60;.001, η<sub>p</sub><sup>2</sup>=0.012); meanwhile, there was no significant change in underdeveloped areas with residential lockdowns.</p>
        </sec>
        <sec>
          <title>Psychoticism</title>
          <p>The main effect of area was significant (<italic>F</italic><sub>1,1788</sub>=4.251, <italic>P</italic>=.04, η<sub>p</sub><sup>2</sup>=.002). The main effect of time was not significant (<italic>F</italic><sub>1,1788</sub>=1.074, <italic>P</italic>=.30, η<sub>p</sub><sup>2</sup>=0.001). The interaction of area and time was marginally significant (<italic>F</italic><sub>1,1788</sub>=3.584, <italic>P</italic>=.06, η<sub>p</sub><sup>2</sup>=0.002). After simple effect analysis, our findings were as follows:</p>
          <p>Area: In the T-before period, the psychoticism of residents of developed areas with residential lockdowns was significantly lower than that of residents of underdeveloped areas with residential lockdowns (<italic>F</italic><sub>1,1788</sub>=7.822, <italic>P</italic>=.005, η<sub>p</sub><sup>2</sup>=0.004); in the T-after period, there was no significant difference between developed and underdeveloped areas with residential lockdowns.</p>
          <p>Time: After the implementation of residential lockdown, the psychoticism of residents of developed areas with residential lockdowns increased significantly (<italic>F</italic><sub>1,1788</sub>=8.768, <italic>P</italic>=.003, η<sub>p</sub><sup>2</sup>=0.005); meanwhile, there was no significant change in underdeveloped areas with residential lockdowns.</p>
          <p>However, for self-acceptance, environmental mastery, positive relations, personal growth, somatization, obsessive-compulsive, depression, and phobic anxiety, the interactions of area and time were not significant (all <italic>P</italic> values &#62;.10).</p>
          <p>The interactions of purpose in life, autonomy, interpersonal sensitivity, anxiety, hostility, paranoid ideation, and psychoticism are presented in <xref rid="figure2" ref-type="fig">Figure 2</xref>.</p>
          <fig id="figure2" position="float">
            <label>Figure 2</label>
            <caption>
              <p>Interactions of area and time on (a) purpose in life, (b) autonomy, (c) interpersonal sensitivity, (d) anxiety, (e) hostility, (f) paranoid ideation, and (g) psychoticism in the residential lockdown areas. T-after: the period after the residential lockdown; T-before: the period before the residential lockdown.</p>
            </caption>
            <graphic xlink:href="jmir_v22i12e24775_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>This study aimed to investigate the impact of the residential lockdown on SWB. We obtained the SWB indices of residents inside and outside cities with residential lockdown before and after the enforcement of the residential lockdown policy through OER. In addition, by introducing economic factors, we also made a transverse comparison of SWB in residential lockdown cities divided by economic development level. The results of the RM ANOVAs revealed that the lockdown group scored lower on negative SWB indicators than the nonlockdown group. Moreover, the SWB of residents in underdeveloped areas remained relatively stable after the implementation of the residential lockdown. On the whole, the strict regulations of the residential lockdown and the limitation on residents’ travel did have an impact on SWB; however, this impact was positive, and the degree of positivity was greater in underdeveloped areas.</p>
        <p>By comparing the residential lockdown cities with corresponding cities without residential lockdowns all over China, the main effect of time from RM ANOVA indicated that as time progressed, the overall SWB of the residents was adversely affected to some degree by the epidemic. This impact was mainly manifested by a general decrease in the scores of positive SWB indicators and an increase in the scores of negative SWB indicators. These results are consistent with previous studies: COVID-19 has caused public pressure and panic owing to the high degree of uncertainty and infectivity of the disease, which has had a deleterious effect on people’s mental health [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref14">14</xref>].</p>
        <p>However, it is worth mentioning that the simple effect of the interaction in the integral analysis indicated that the implementation of the residential lockdown had a positive influence on the control of residents’ negative mental states. Specifically, compared with the nonlockdown group, residents in the lockdown group scored lower on negative SWB indicators. This finding also suggests that stringent residential lockdowns during a pandemic will not only ensure residents’ health and life but will also effectively control the prevailing negative mental states of residents. Our findings are in keeping with those of Suryawanshi and More [<xref ref-type="bibr" rid="ref43">43</xref>], who reported that the positive impact of the lockdown was far greater than the negative impact. Two factors may explain the above results. First, because the residential lockdowns were implemented only after the outbreak of COVID-19, people had a full understanding of the epidemic and were aware that only residential lockdown could effectively stop the spread of the virus by cutting off the transmission route. Therefore, on balance, because the powerful residential lockdown slowed the spread of the virus and curbed the rapid deterioration of the epidemic, it provided greater psychological comfort to the residents compared with the discomfort caused by restriction of personal freedom [<xref ref-type="bibr" rid="ref43">43</xref>]. Second, the residential lockdown offered family members an opportunity to reevaluate and improve their family relations [<xref ref-type="bibr" rid="ref43">43</xref>], which could effectively relieve their state of mind.</p>
        <p>Furthermore, we used GDP per capita as an indicator of economic development level to classify the cities under residential lockdown. After performing RM ANOVA, we found that the positive impact of the residential lockdown was different in areas with different economic development levels. The SWB of residents in underdeveloped areas with residential lockdown (eg, Huanggang, Huangshi) was found to be relatively stable over time. In contrast, the results showed that during the lockdown in developed areas (eg, Wuhan, Zhongshan), the SWB of the residents generally changed significantly for the worse, although two SWB indicators did not show significant changes (ie, purpose in life and autonomy). The difference in the stability of residents’ mental states between the residential lockdown areas at high and low economic development levels can mainly be explained by the following reasons.</p>
        <sec>
          <title>Urban and Rural Population Ratio</title>
          <p>Economists generally believe that regional economic growth is related to population structure (eg, urban and rural population ratio), among which GDP per capita is positively associated with urban population size [<xref ref-type="bibr" rid="ref44">44</xref>]. In the residential lockdown areas with higher economic development, the urban population size is larger, and the problems produced by the residential lockdown (eg, unemployment) had a strong impact on urban commuters, which posed great risks to local residents’ SWB.</p>
        </sec>
        <sec>
          <title>Communication and Transportation</title>
          <p>The statistical yearbooks of the residential lockdown cities reported that in the more economically developed areas, key indicators (eg, passenger traffic, number of civil vehicles) would score higher. For example, in 2017, the passenger traffic of Wuhan was 299.5 million, and the number of civil vehicles was 2.75 million [<xref ref-type="bibr" rid="ref45">45</xref>]. These figures show that residents of more economically developed areas may have had greater transport demand and therefore were more affected by stringent residential lockdown due to the restrictions on their travel.</p>
        </sec>
        <sec>
          <title>Floating Population</title>
          <p>Economic development is the decisive factor in the formation of population flow. The population usually flows to developed areas with better economic development [<xref ref-type="bibr" rid="ref46">46</xref>]. During the residential lockdown, the original pattern of life was disrupted, face-to-face association outside home was cut off, and residents mainly obtained social support from family members [<xref ref-type="bibr" rid="ref47">47</xref>]. However, most members of the floating population make their living without the company of family. Hence, in more economically developed areas, the size of the floating population without family is larger, and the psychological impact of the residential lockdown on residents was more significant.</p>
          <p>With the fast rise in the number of confirmed cases, COVID-19 has become a global pandemic. The decision of whether to enforce residential lockdowns is a difficult challenge faced by governments worldwide. The above results indicate that residential lockdowns not only have important medical value in protecting public health and life safety but may also have psychological value in maintaining SWB in China. Furthermore, in developed areas, the urban and floating populations are larger, and the relationship between transportation and life is more important; thus, the SWB of local residents is more likely to be affected by the residential lockdown and fluctuate greatly. These findings provide new references for local governments of areas at different economic development levels to consider the benefit and cost of residential lockdown and to prepare for the possible risks. For example, local governments in developed areas should make more preparations for psychological interventions and associated costs during and following residential lockdown.</p>
          <p>To date, Britain, America, and many other countries have adopted lockdowns that are similar to those in China to some extent. Despite cultural differences, the effectiveness of residential lockdown in stopping disease spread is obvious [<xref ref-type="bibr" rid="ref48">48</xref>]. However, the positive and negative psychological effects of the lockdown are complicated. These effects will also be influenced by the enforcement time, the effects of lockdown, and other factors mentioned above. In addition, in view of the fact that the level of economic development is a common indicator, different regions of the world will also have differences in urban and rural population ratios, floating population, communication and transportation, etc, which may influence the psychological effects caused by residential lockdown. Our findings with regard to the overall effect of the residential lockdown on SWB and the differences in the impact on mental states under different economic development conditions are instructive to analogous policies around the world.</p>
        </sec>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>Although this study reveals changes in SWB caused by residential lockdown, there are some limitations to be highlighted. First, considering that most of the respondents in our sample are female, there may be some bias in the results. Second, more than 70% of our sample did not provide age information on the internet, which prevented us from evaluating the possible influence of age. In future studies, obtaining more age information and expanding the ranges of age and gender could be helpful. Third, in this study, transverse comparison of SWB in cities divided by economic development level only targeted residential lockdown areas; therefore, in future studies, this comparison can be extended to areas without residential lockdowns. Fourth, in light of the fact that not only economic factors but other factors such as social environment and cultural background may affect SWB, future studies could consider more factors to obtain a more comprehensive understanding of the lockdown effect. Additionally, it should be noted that the patterns we observed may be largely determined by the Chinese culture, and any application of our conclusions to a different culture should be made very carefully.</p>
      </sec>
      <sec>
        <title>Conclusion</title>
        <p>In this study, to explore the impact of residential lockdown during the COVID-19 pandemic on individual SWB in China, we predicted residents’ SWB by OER and compared the SWB of residents of different areas with different economic development levels. The results demonstrated that in China and in the context of the COVID-19 pandemic, the residential lockdown alleviated the negative psychological changes caused by the epidemic to a certain extent. In addition, compared with developed areas, the psychological benefit of the residential lockdown was more obvious in underdeveloped areas. This study sheds light on the psychological effects of strict residential lockdown during pandemics and provides new clues for epidemic prevention in areas with different socioeconomic situations.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>CONSORT-eHEALTH checklist (V 1.6.1).</p>
        <media xlink:href="jmir_v22i12e24775_app1.pdf" xlink:title="PDF File, 1MB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">GDP</term>
          <def>
            <p>gross domestic product</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">OER</term>
          <def>
            <p>online ecological recognition</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">PWB</term>
          <def>
            <p>Psychological Well-Being scale</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">RM ANOVA</term>
          <def>
            <p>repeated measures analysis of variance</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">SCL-90</term>
          <def>
            <p>Symptom Checklist 90</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">SCLIWC</term>
          <def>
            <p>Simplified Chinese Language Inquiry and Word Count</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">SWB</term>
          <def>
            <p>subjective well-being</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb8">WHO</term>
          <def>
            <p>World Health Organization</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This study is financially supported by National Natural Science Foundation of China (31700984), Youth Innovation Promotion Association CAS, National Key Research &#38; Development Program of China (2016YFC1307200), and China Social Science Fund (17AZD041).</p>
    </ack>
    <fn-group>
      <fn fn-type="con">
        <p>NZ and TZ conceived and planned the article. NZ is the principal investigator and the guarantor of the paper. YW and NZ carried out the study and drafted the manuscript. DJ and PW collected the data. YW, PW, and SL analyzed the data. NZ, XL, YW, and TZ reviewed and edited the manuscript.</p>
      </fn>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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