Automatic text summarization (ATS) is a leading topic in the field of information retrieval research, particularly in the medical and biomedical domains, which offers an efficient solution to access the ever-growing amount of scientific and clinical literature by summarizing the source documents while maintaining their most informative contents [1]. The large quantity of biomedical data now accessible to clinicians makes it challenging to locate the correct data rapidly; thus, automatic summarization can provide highlights particular to clinical needs [2]. Moreover, achieving precise, succinct, and coherent information extraction from credible published biomedical resources to construct a simplified summarization plays an imperative role in clinical decision-making, educating patients, and medical education. At the same time, automating this process will provide better opportunities for users to obtain the most critical points of required clinical knowledge without having to delve into an enormous amount of text, saving hours of searching. It is highly desirable to accurately identify scientifically sound published studies and summarize selected studies against a given type (eg, intervention and prognosis) of clinical query.

The primary requirements in carrying out this task of extracting noteworthy information are the efficiency of the process, contextualization, and precision of retrieved contents. Efficiency pertains to reducing human involvement and achieving the required materials in a timely manner; contextualization refers to the user objective relevant to a clinical task; and precision of contents applies to the correct identification of needed contents from trustworthy resources. Owing to the massive increase in the biomedical research literature, finding relevant, scientifically sound, and fit-to-context information has become more and more challenging for precise automatic text classification and summarization. The field of text classification and ATS is well-explored [3-7]; however, minimal work has been done in a clinically fit-to-context summary of biomedical text [8,9]. Medical text summarization poses a unique set of challenges compared to summarization in other domains [10].

The main limitations of existing medical text summarization are as follows: (a) inability to capture the clinical context while ranking the sentences for the summary; (b) lack of consideration in checking the quality of the documents before performing summarization; (c) inability of identifying context and implicit information present in the biomedical text, which cannot explicitly match with the user query; (d) lack of purpose-driven ranking and selection of passage for the final summary; and (e) nonuse of a large training set for training deep neural network models. To overcome these limitations, this paper introduces a novel framework called Biomed-Summarizer, which provides a quality-aware Patient/Problem, Intervention, Comparison, and Outcome (PICO)-based intelligent and context-enabled summarization of contents of biomedical literature to satisfy the requirements listed above. Unlike the use of traditional features using a bag of words (BoW) approach, in which the text is tokenized into multiple words and each word is given a number representing the frequency of its use [3], more powerful word-embedding techniques have recently been introduced, such as word2vec [11,12] and GloVe [13], to combat the issues of data sparseness and context-overlooking by generating a vector space, typically of several hundred dimensions [14]. The word2vec approach creates vectors at the sentence or document level by employing the sentence2vec or doc2vec model [15]. The Biomed-Summarizer framework uses the Keras tokenizer [16] to generate a contextually rich set of features with a compact number of dimensions to enable semantics-based matching for precise extraction, summarization of contents, and avoiding sparseness. These features are then used as input to our bidirectional long-short term memory (Bi-LSTM) [17] classification model to identify the PICO sequence. PICO was initially proposed for formatting a clinical question. Subsequently, researchers have used the PICO structure for information retrieval and sentence identification in the text of biomedical documents [18-21]. In deciding which sequences to include in the final summary, we considered a comprehensive criterion that provides information on the quality of the study to which that sequence belongs, the relevance of the sequence to the user query, study type, credibility of the publishing venue, and freshness in term of the date of publication.

In summary, the main contributions of this paper are as follows. First, we introduce a novel framework, termed Biomed-Summarizer, for extractive multidocument ATS of biomedical documents. The summary construction is based on PICO elements identified in each record. Additionally, we employ contextual and quality parameters for the selection of a subset of a PICO sequence of sentences to include in the final summary.

Second, for quality recognition, a highly optimized multilayer feed-forward neural network model, multilayer perceptron (MLP), is presented to acquire significantly accurate results. This model offers binary classification to identify the soundness of a study based on data (title and abstract) and metadata (article type, authors, and publishing venue and date) features.

Third, for PICO elements classification, we propose a Bi-LSTM recurrent neural network (RNN) model trained on the vector representation of the text, which significantly boosts the performance compared to conventional machine-learning models such as support vector machine (SVM), logistic regression, decision tree, and naïve Bayes. Unlike previous studies that focused on the detection of PICO elements one-by-one by employing a separate binary classifier for each PICO element, the proposed approach is a multiclassifier model, which classifies PICO sequences simultaneously from any given biomedical study.

Fourth, to accurately extract the PICO sentences to be included in the final summary, we present a novel method of calculating the similarity between the query and medical text using the Jaccard coefficient after semantically enriching the text using medical ontologies.

Finally, we offer a publicly available dataset [22] comprising thousands of abstracts related to intracranial aneurysm (also known as cerebral or brain aneurysm) curated from the biomedical literature for PICO-based classification. Additionally, another open-source dataset [22] is presented for the quality recognition model.

We aimed to achieve these contributions through the precise, succinct, and coherent information extraction from credible published biomedical resources, and to construct a simplified summary containing the most informative contents that provide a review particular to clinical needs.

Figure 1 shows the architecture of the proposed Biomed-Summarizer framework highlighting four main modules: data preprocessing, quality recognition, contextual text classification, and text summarization. The main tasks in data preprocessing are sequence marker, cleaning, tokenization, vector generation, and feature creation. The quality recognition module identifies the scientific soundness of a study using a feed-forward deep-learning binary classifier that is trained on biomedical data and metadata features. The contextual text classification classifies the PICO sequence of sentences in the selected quality documents using the Bi-LSTM model, an RNN trained on a large set of data acquired from BioNLP [21] and domain-specific Medline abstracts. Lastly, the summarization module generates a summary from the classified PICO sequences of multiple documents using a sequence scoring method consisting of semantic similarity (between a query and a text sequence extracted from a biomedical study), the publishing venue’s credibility, and year of publication.

Biomed-Summarizer acquires data from two input sources: BioNLP dataset and PubMed. The BioNLP dataset is publicly available, whereas we retrieved the domain-specific abstracts from PubMed. The process used to parse raw abstracts retrieved from the PubMed and BioNLP is described below.

The proposed model, as shown in Figure 2, comprises multilayer feed-forwarded neural networks as a so-called MLP. The MLP is further optimized with an ensemble method using adaptive boosting (AdaBoost). The final AdaBoost-MLP, termed the prognosis quality recognition (PQR) model, was trained on a dataset acquired automatically through PubMed searches based on the following two criteria: selecting the “Clinical Query prognosis” filter and choosing scope as “narrow.” To build and evaluate the model, we performed the steps involved in the preparation of a dataset for training the deep-learning models, followed by training and tuning the deep-learning models. Additionally, we compared the performance of the proposed model with those of shallow machine-learning models in terms of precision and recall.

For training and testing the PQR model, we collected a dataset consisting of a total of 2686 Medline abstracts, 697 of which were considered to be positive studies (ie, scientifically sound). To retrieve positive studies, we used the interface of Clinical Queries [33]. To retrieve negative studies (ie, not scientifically sound), we used the interface of PubMed and retrieved studies that were not included in the positive set.

The PQR model is trained using five textual features, including two data features (title and abstract) and three metadata features (article type, publishing journal, and authors). The data features were preprocessed through applying the steps described above. The model consists of 5 layers with 3 hidden layers of size 100, 50, and 25, respectively. The input layers take the BoW vectors generated from data features. The “Maxout” activation function was used with 10 epochs. The data were split into a 70:30 ratio for training and testing.

To identify the best performer on our dataset, we compared a set of machine-learning algorithms, including SVM, naïve Bayes, k-nearest neighbor, and decision tree. These algorithms were tested in other studies [35,39] for addressing similar problems.

The CCA classification model aims to develop a multiclass classifier that can accurately classify text from selected quality documents (given by the quality model) into one of the following 7 classes: Aim, Methods, Population, Intervention, Results, Outcome, and Conclusion. We then merged Methods and Population into a single category (P) and Outcome and Conclusion into a single category (O) because of their strong correlation found in the text. Although our focus was to utilize PICO classes in the summarization task, we retained the other categories to enable additional non-PICO clinical applications such as summarization for medical education and deriving rules from clinical trials for developing the knowledge base of a clinical decision support system.

PICO is a well-known terminology in evidence-based medicine. Our proposed CCA classifier incorporates the Patient/Problem, Intervention, and Outcome PICO components in addition to two more classes, Aim and Results. PICO detection is a sequential sentence classification task rather than a single sentence problem; therefore, the sequence of sentences is jointly predicted. In this way, more complete context is captured from multiple sentences, which then improves the classification accuracy of predicting the current sentence. The steps followed to build and evaluate the model were: (a) preparation of a dataset for training the deep-learning model, (b) training and tuning the deep-learning model, and (c) comparison with traditional machine-learning models in terms of precision and recall.

The neural network model is heavily used in text processing due to the ability to process arbitrary-length sequences. RNNs are immensely popular in multiclass text classification. To build and evaluate the classification model, we employed the Bi-LSTM model as a type of RNN. This model preserves the long-term dependency of the text and is one of the most popular models in text classification.

As shown in Figure 3, the input layer consists of 250 dimensions showing the numeric features created using the Keras tokenizer, embedding layer, LSTM logical hidden layers, classification layer, and output layer. In brief, the trained CCA model has the following features: (1) an initial training dataset comprising 173,401 records, 90% (n=156,060) of which were used for training and 10% (n=17,341) of which were used for testing; (2) the first hidden layer is the embedding layer that uses 100-dimension vectors to represent each paragraph; (3) the next layer is the LSTM layer with 100 memory units, and the recurrent dropout rate was set to 0.2; (4) the next layer is the dense layer with 5 nodes, and we used the SoftMax activation function for multiclassification, and categorical_crossentropy as a loss function; (5) the training dataset is further divided into two parts, 10% of which was used to validate the category and minimize the loss function, resulting in 140,454 records used for training and 15,606 used for validation; (6) the model was then trained across 5 epochs with a minibatch size of 64.

For the ATS task, we developed a sentence-scoring mechanism based on a multifeatured matrix, consisting of 4 features (relevance, study type, venue credibility, and freshness), where each feature was learned with a specific method as explained in the following sections.

First, an individual score value is assigned to each feature, which is then aggregated in the final column as a final score using the formula in Equation 1:

where R_score is the relevance score, ST_rank is the study type rank, VC_score is the publishing venue credibility score, f_score is the freshness score, and β=70 and γ=10 are the scaling constants to keep the aggregate score in the range of 0 to 100.

For the relevance score, we developed a semantic similarity algorithm, Jaccard similarity with semantic enrichments (JS²E) as a 6-step algorithm that uses the BioPortal application programming interface to access biomedical ontologies (SNOMED CT, MedDRA, NBO, NIFSTD) for obtaining semantic enrichment and the Jaccard similarity metric to find similarities between two texts.

In step 1, an individual sequence of text is obtained from the query, which is preprocessed to remove the special characters, separate characters, and different formatting tags. In step 2, the preprocessed text is annotated using BioPortal. In step 3, each token is enriched using “definition,” “synonyms,” and “prefLabel” relations from selected ontologies. In step 4, the annotations of text are retrieved using the “definition” relationship, along with the preprocessing (step 1) and annotation (step 2) procedures. In step 5, the annotated tokens received in step 2 are combined with the “synonyms” and “preflabel” obtained in step 3 and the annotated tokens received in step 4, and the data structure of metatokens is constructed. Finally, in step 6, the Jaccard similarity between the metatokens of the text sequence and the query is calculated using Equation 2:

where S_m are the metaset tokens of the text sequence in a document and Q_m are the metaset tokens of the query.

The study type plays a vital role in proving a study’s usefulness for a user concerning a clinical task. For instance, if a surgeon wants to look for advances in successful surgical treatments, randomized control trials or a meta-analysis of randomized controlled trials will be the priority. The priority will change if the user is interested in prognosis-related studies. Study types can be used to grade evidence concerning quality and other elements [34,51,52]. To find the priority of different study types in the category of prognosis, we conducted a questionnaire-based survey among domain experts who were asked to assign a score value for each study type. An example of a filled-in questionnaire by a physician is provided in Multimedia Appendix 1.

The final rank value is then learned from the average value of rank values assigned by the domain experts, as shown in Equation 3.

where V_i represents the rank values assigned to a study type by each domain expert, n is the total number of domain experts that participated in the questionnaire, and α=0.1 is a scaling constant to keep the final score value in the range of 0 to 1.

The credibility of a study publishing venue, including journals, proceedings, and books, is also an important parameter; however, it is more of a subjective matter. Therefore, it is necessary to consult with the stakeholders of the service. For this study, we sought to obtain a list of valuable publishing venues. We involved resident doctors to rank various venues concerning their credibility. An example of a filled questionnaire by a physician is provided in Multimedia Appendix 1. The final credibility score was determined from the average value of rank values assigned by the domain experts, as shown in Equation 4:

where S_i is the initial rank assigned by the domain experts, S_f is the mapped score obtained through mappings {1→10, 2→9, 3→8, 4→7, 5→6, and 6→5}, and α=0.1 is a scaling constant to keep the final score value in the range of 0 to 1. We applied the majority vote method before using the mapping function.

Freshness represents the date of publication of a study, which is useful to consider to keep up with the advancement in a domain. We included this attribute in summarization with a higher rank assigned to more recent studies, following the less current studies, as described in Table 2.

The final score was calculated according to Equation 5:

where R_i is the initial value assigned to each year obtained from Table 2, R_f is the mapped score obtained through mappings {1→10, 2→9, 3→8, and 4→7}, and α=0.1 is a scaling constant to keep the final score value in the range of 0 to 1.

The aggregate score calculated using Equation 1 provides the final rank values for a text sequence. Two types of summary structures can be generated: (1) a PICO-based summary, in which we select the top k text sequences in each part of PICO out of a total n number of sentences to be included in the final summary as |n/k| sentences from the Patient/Population component, |n/k| sentences from the Intervention component, and |n/k| from the Outcome component; and (2) a non-PICO-based summary, where we select the top k text sequences without considering their classification.

Our proposed model of automatic summarization can generate a summary for a single document or multiple documents simultaneously. For summaries of a single document, the selected set of representative PICO sequences is arranged in a template of Population/Problem, Intervention, and Outcome, as shown in Textbox 2. The templates are displayed according to the number of documents retained after a quality check. For instance, if we have a set of 5 studies retrieved against a user query, our algorithm will generate 5 individual summaries presented in the order of the most recent document summary followed by the others.

In the case of a multidocument summary, our algorithm first identifies PICO sequences in all documents, finds the score for each sequence, selects the highest-scoring sequence in each category, and concatenates all scored sequences to obtain a combined summary of each type. In this case, the sequences included in the summary may or may not belong to a single document; however, each sequence is linked to its corresponding documents for audit, transparency, and education.

To clarify the steps of the proposed Biomed-Summarizer framework, we take the following example query: “How does family history affect rupture probability in intracranial aneurysms; is it a significant factor?“ (Abstract Query-Intracranial aneurysm family history). As shown in Figure 4, the user query was first abstracted from a detailed user query to increase the recall of retrieving studies. Second, the query was run on the PubMed search service, which returned a total of 239 studies, 130 of which were prognosis studies. Third, these studies were run through a quality model, “PQM,” which identified 74 studies as scientifically sound and the rest were filtered out. Fourth, the set of 74 studies was given to the PICO classification model in the form of text sequences, which were classified into five classes: Aim (32), Patients (9), Intervention (1), Results (168), and Outcome (49). Fifth, the PICO text sequences and the detailed query were passed through semantic similarity, in which the texts were first enriched semantically using medical ontologies, and the similarity score was calculated using the Jaccard coefficient. Sixth, the documents were ranked according to the accumulated score of four parameters: relevance score of the query and text, study type, venue’s credibility score, and freshness score. Finally, the required summary is created and presented to the user.

To evaluate the performance of the proposed framework, we prepared two different datasets to test the proposed Biomed Summarizer framework. One dataset was used for the development and testing of the PQR model (D1), whereas the other was used for the development and testing of the CCA model (D2). The preparation protocols of both datasets are outlined in Table 3. These datasets are available to the research community via a GitHub link [22].

To evaluate the CCA and PQR classification models, we performed experiments on a 64-bit Windows operating system with an Intel Core i5 CPU, 3.20-Hz processor with 8-GB memory using dataset D1 and D2, respectively. The experiment was performed using RapidMiner studio [54] to train and test the PQR models, whereas the python deep learning library Keras was used for the CCA classification model [55].

The aim of this experiment was to quantify the comparative analysis of the proposed deep-learning model with other machine-learning models. Using the default settings of RapidMiner, the SVM model followed the kernel type “dot,” kernel cache of 200, and complexity constant c of 0.0; the DT criterion was “gain_ratio” with a maximum depth of 10; the k of the k-nearest neighbor was 5 with the mixed measure of “MixedEuclideanDistance.” The comparison of the performance of these models with that of a deep-learning model was assessed in terms of the F1-score, accuracy, and area under the curve (AUC) value, as shown in Table 4.

We tuned the hyperparameters of the MLP by varying the hidden layers, size of layers, activation function, and epochs, and obtained varied results as shown in Table 5.

As highlighted in Table 5, the highest accuracy and F1-score were obtained with the setting of 3 hidden layers consisting of 100, 50, and 25 neurons, respectively. The activation function was set to Maxout, and the model was trained on 10 epochs. Finally, we boosted the performance of the selected model with an ensemble approach using AdaBoost. The results of the optimized version of the proposed model are shown in Table 6, demonstrating an F1-score of about 97% and an accuracy of 95.41% with an AUC of 0.999.

We experimented with the combination of dataset D1 described above. The classification model results are shown in Table 7.

The individual decision class performance of the proposed model is reported in Table 8. We found high F1-score values (≥80) for classes with top support (Aim, Outcome, Results, Population) as compared to the scores of the minor classes, which indicated that the dataset size needed to be increased for each of these minor classes to obtain a higher F1-score.

We measured the correlation strength based on the standard guideline of the Pearson correlation coefficient in the biomedical domain [20]. We evaluated different similarity approaches, including string similarity (Jaccard), term frequency (count vectorizer), and pretrained word embedding using GloVe, Google word2vec, and fastText. The results showed that semantic enrichment is crucial to find the similarity between the texts because it significantly increases the size of the token set of texts by including synonyms, definitions, and prefLabel from ontologies. We tested this method on a well-known biomedical dataset, BIOSSES [56], which contained 100 pairs of sentences manually annotated by the experts. As shown in Table 9, the Pearson correlation coefficient after semantic enrichment increased by 8.9% relative to that of the best-performing Jaccard similarity. Concerning the pretrained word-embedding model GloVe, word2vec (Google), and fastText (Facebook), the correlation improved by 41.8%, 60.5%, and 17.3%, respectively.

The PICO-based summary obtained after classification and performing JS²E was then compared with the classical summary obtained using JS²E without classification. We considered the JS²E summary without classification as a baseline summary. Evaluation and comparison of two summaries were performed by three independent evaluators and scored between 0 and 5 on the following three metrics: summary relevance to the inbound query (M1); Aim, Population, Intervention, Results, and Outcome classification representation in the summary (M2); and model summary better than the baseline summary (M3).

Table 10 shows the Pearson correlation coefficients of the scores of each evaluator (A, B, and C) concerning the average scores of the remaining two evaluators for each evaluation metric (M1, M2, and M3). There was a strong association among the scores of each evaluator concerning each metric, suggesting that automated summarization performed best on all three parameters. The lowest correlation coefficient was 0.728, which is still considered to be high on the correlation scale.

The distribution of the scores by each of the evaluators concerning each metric is described in Table 11. The distribution suggests that there are sufficient instances for each of the scores in the evaluation dataset.

The proposed Biomed-Summarizer framework generates extractive summaries for single and multiple documents with acceptable accuracy. The evaluation results signify that the proposed framework performs significantly better than existing approaches, which was also evident from the correlation matrix generated by comparing the candidate and reference summaries obtained for each defined parameter. The PQR model trained on a large dataset of biomedical literature of intracranial aneurysm showed an accuracy of 95.41% in terms of recognizing quality articles. The CCA multiclass classification model outperformed the traditional machine-learning algorithms and achieved 93% accuracy for classifying five categories: Aim, Population, Intervention, Results, and Outcome. The semantic similarity algorithm demonstrated a significant Pearson correlation coefficient of 0.61 (on a 0-1 scale) from a well-known BIOSSES dataset after semantic enrichment, representing an improvement of 8.9% over the baseline Jaccard similarity score.

An accurate clinical summarization is expected to revolutionize the field of domain-specific knowledge graphs [57] and clinical decision support systems. For example, an individual PICO-extracted element from a biomedical text could be represented as a relationship in a knowledge graph, which could then be used for various clinical applications or could be directly supplied to clinical decision support systems for physicians to link to internal data-driven instances. The importance of linking external evidence (extracted from the biomedical literature) to internal evidence is important when the internal data are unable to capture all critical risk factors. One of our motivations was to extract the evidence from a PICO-based summarization of documents relevant to intracranial aneurysm (also known as cerebral or brain aneurysm). Since neither decision support systems nor knowledge graphs providing external evidence for complex neurological diseases such as intracranial aneurysm exist, there is a need to achieve automated summarization for such conditions to enhance translational research and clinical decision making synergistically. The proposed automated summarization framework will be pivotal to develop a hybrid machine-learning and knowledge-based clinical decision support system, termed NeuroAssist [58], which aims to predict aneurysmal rupture (ie, subarachnoid hemorrhage). The other possible application areas of the proposed framework include automation of writing systematic reviews over a set of published clinical trials, extraction of evidence for evidence-based medicine, precision medicine, and development of clinical assistants/chatbots.

The current work in the biomedical domain is mainly focused on issues of concept- or sentence-based relevance without relating a concept or sentence to a clinical context. Although the sentence-based classification approach is well-regarded for ATS, relying on only the relevance of a sentence without capturing its clinical context and semantics may lead to a clinically undesirable summary. Some of the summarization work focuses on creating summaries from abstracts only, which may result in low recall due to missing an important sequence of text that exists only in the body of the document. In addition, in previous works, the dataset used for training and testing [29] contained only 1000 abstracts, which is not sufficient for a deep-learning model to be generalized. Recently, a new dataset was published in the BioNLP 2018 proceedings [21], but it does not consider the quality evaluation of the source documents used for extracting the text for summarization. Therefore, we curated a dataset comprising over tens of thousands of abstracts from Medline and combined it with the BioNLP dataset.

PICO-based ATS remains an unexplored area; however, work has been done on individual aspects such as PICO elements identification in the text [21,29,30], quality recognition of therapy-related biomedical studies [40,41], and sentence-based summarization without PICO and quality evaluation [3,32]. To the best of our knowledge, the proposed Biomed-Summarizer framework for biomedical ATS is the first of its kind to use a quality recognition model, PICO-based classification using LSTM-based recurrent deep neural network model for key sentence identification trained on contextual vectors, and the JS²E algorithm for semantic matching of the user query and PICO text sequences.

The proposed approach offers a few potential benefits compared to existing methods. First, unlike traditional machine-learning approaches that depend on features that are well-structured and less noisy, deep learning deals well with an unstructured noisy text. Therefore, our deep-learning model can be reused for domains using data of the same nature. Additionally, the accuracy of the proposed deep-learning model is expected to increase further if the volume of the dataset is extended. Second, our approach considers the quality evaluation of the documents being used in summarization in addition to publishing venue credibility, which offers two-fold benefits: it enhances the confidence of physicians on the system-generated summary and has applicability in real clinical settings, and, because it filters out the documents with the lowest quality from the retrieval set, the computational time of summary creation is reduced with respect to checking the similarity of the text with the query. Third, our proposed model is based on the PICO structure, which provides additional semantics as compared to a non-PICO approach in terms of understanding the problem, interventions, and outcomes.

Traditional approaches are not cognizant of capturing the clinical context; therefore, the resultant summary includes sentences based on a high similarity score and sentence position, and is therefore less clinically effective. Textbox 3 shows an example of a summary generated by the proposed method considering the clinical context; sequence 1 represents the aim of the study, sequence 2 represents the patient population included in the study, and sequence 3 represents the outcome of the study. In contrast, the conventional method selects the top three sequences based on high relevancy but misses the clinical context.

The training datasets could be reviewed for the noise generated during the creation of automated annotation to obtain even more accurate results in PQR and CCA models. The current summary is a textual summary that contains sentences in the original form as they are presented in the source documents without any further processing to extract statistical information for an easy catch up of the contents.

Compared to traditional approaches, state-of-the-art deep neural network models can achieve high accuracy for an ATS task when trained on nonsparse semantically enriched features. Additionally, the automated pipeline for seeking research evidence can enable the seamless curation of voluminous biomedical literature to use in clinical decisions. By designing the proposed Biomed-Summarizer framework, we employed a set of methods for information extraction from credible published biomedical resources to construct a simplified summary that is precise, relevant, and contextually suited to clinical needs. We designed the framework to provide openness for other researchers to use, extend, or even make use of a subpart of it and extend for designing their own systems and services. Alongside the framework, we created a specialized dataset containing PICO elements and a few other text sequences such as Aim, Method, and Result for researchers to use in their experiments in the domain of brain aneurysm. The PICO dataset was extended using a custom data-mining process by incorporating the rigorous text processing techniques on PubMed research documents. This method can be further used to create a PICO dataset in other related biomedical domains by obtaining related research papers from PubMed. The evaluation results signify that the proposed Biomed-Summarizer framework performs significantly better than existing approaches.