<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "http://dtd.nlm.nih.gov/publishing/2.0/journalpublishing.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="2.0">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v21i2e11711</article-id>
      <article-id pub-id-type="pmid">30785408</article-id>
      <article-id pub-id-type="doi">10.2196/11711</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Paper</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Original Paper</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>How Do Adolescents Use Electronic Diaries? A Mixed-Methods Study Among Adolescents With Depressive Symptoms</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Eysenbach</surname>
            <given-names>Gunther</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Hetrick</surname>
            <given-names>Sarah</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Păsărelu</surname>
            <given-names>Costina</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="author" id="contrib1" corresp="yes" equal-contrib="yes">
          <name name-style="western">
            <surname>Metsäranta</surname>
            <given-names>Kiki</given-names>
          </name>
          <degrees>RN, MNSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Department of Nursing Science</institution>
            <institution>University of Turku</institution>
            <addr-line>Hoitotieteen laitos</addr-line>
            <addr-line>Joukahaisenkatu 3-5</addr-line>
            <addr-line>Turun yliopisto, 20014</addr-line>
            <country>Finland</country>
            <phone>358 456716156</phone>
            <email>kianme@utu.fi</email>
          </address>
          <ext-link ext-link-type="orcid">http://orcid.org/0000-0001-8910-5500</ext-link>
        </contrib>
        <contrib contrib-type="author" id="contrib2" equal-contrib="yes">
          <name name-style="western">
            <surname>Kurki</surname>
            <given-names>Marjo</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">http://orcid.org/0000-0003-0737-2870</ext-link>
        </contrib>
        <contrib contrib-type="author" id="contrib3" equal-contrib="yes">
          <name name-style="western">
            <surname>Valimaki</surname>
            <given-names>Maritta</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">http://orcid.org/0000-0001-7234-2454</ext-link>
        </contrib>
        <contrib contrib-type="author" id="contrib4" equal-contrib="yes">
          <name name-style="western">
            <surname>Anttila</surname>
            <given-names>Minna</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">http://orcid.org/0000-0003-4523-5324</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
      <label>1</label>
      <institution>Department of Nursing Science</institution>
      <institution>University of Turku</institution>  
      <addr-line>Turun yliopisto</addr-line>
      <country>Finland</country></aff>
      <aff id="aff2">
      <label>2</label>
      <institution>Department of Nursing Science</institution>
      <institution>University of Turku</institution>  
      <addr-line>Turku</addr-line>
      <country>Finland</country></aff>
      <aff id="aff3">
        <label>3</label>
        <institution>Hong Kong Polytechnic University</institution>
        <addr-line>Hong Kong</addr-line>
        <country>China</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Kiki Metsäranta 
        <email>kianme@utu.fi</email></corresp>
      </author-notes>
      <pub-date pub-type="collection"><month>02</month><year>2019</year></pub-date>
      <pub-date pub-type="epub">
        <day>20</day>
        <month>02</month>
        <year>2019</year>
      </pub-date>
      <volume>21</volume>
      <issue>2</issue>
      <elocation-id>e11711</elocation-id>
      <!--history from ojs - api-xml-->
      <history>
        <date date-type="received">
          <day>26</day>
          <month>7</month>
          <year>2018</year>
        </date>
        <date date-type="rev-request">
          <day>21</day>
          <month>9</month>
          <year>2018</year>
        </date>
        <date date-type="rev-recd">
          <day>16</day>
          <month>11</month>
          <year>2018</year>
        </date>
        <date date-type="accepted">
          <day>23</day>
          <month>11</month>
          <year>2018</year>
        </date>
      </history>
      <copyright-statement>©Kiki Metsäranta, Marjo Kurki, Maritta Valimaki, Minna Anttila. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 20.02.2019.</copyright-statement>
      <copyright-year>2019</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="http://www.jmir.org/2019/2/e11711/" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>Depression in adolescence is common. Less than half of the adolescents with depression receive mental health care; furthermore, treatment tends to be suspended, and its success rates are low. There is a need for these adolescents to have a safe place to share their thoughts. Studies have shown that writing may be a useful treatment method for people with mental health problems.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This study aims to describe the use of an electronic diary (e-diary) among adolescents with depressive symptoms.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>This paper describes a substudy of a randomized controlled trial. We used a mixed-methods approach to understand the way in which e-diaries were used by participants in the intervention under the randomized controlled trial. Data were collected during 2008-2010 at 2 university hospitals in Finland. Study participants (N=89) were 15-17-year-old adolescents who had been referred to an adolescent outpatient psychiatric clinic due to depressive symptoms. Participants were instructed to use the e-diary at least once a week to describe their thoughts, feelings, and moods. The content of the e-diary data was analyzed using descriptive statistics and inductive content analysis.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>Overall, 53% (47/89) of the adolescents used the e-diary. Most of them (39/47, 83%) logged into the program during the first week, and about one-third (19/47, 40%) logged into the e-diary weekly as suggested. The number of words used in the e-diary per each log ranged between 8 and 1442 words. The 3 topics most often written about in the e-diary were related to mental health problems (mental disorder), social interaction (relationship), and one’s own development (identity).</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>An e-diary may be a usable tool to reflect experiences and thoughts, especially among adolescents who have signs of depression. The results of this study can be used to develop user-centered electronic health applications that allow users to express their own thoughts and experiences in ways other than systematic mood monitoring.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>adolescent</kwd>
        <kwd>depression</kwd>
        <kwd>electronic diary</kwd>
        <kwd>mental health</kwd>
        <kwd>mobile phone</kwd>
        <kwd>outpatient care</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <p>Depression in adolescence is common, and it causes serious impairments of one’s social, academic, and emotional lives [<xref ref-type="bibr" rid="ref1">1</xref>]. Depression is often unrecognized [<xref ref-type="bibr" rid="ref2">2</xref>] and is an undertreated disorder [<xref ref-type="bibr" rid="ref1">1</xref>]. It may increase the risk of drug use [<xref ref-type="bibr" rid="ref3">3</xref>] and suicide among adolescents [<xref ref-type="bibr" rid="ref2">2</xref>]. More than half of the adolescents with depression do not receive mental health care [<xref ref-type="bibr" rid="ref4">4</xref>]. Those who have access to care tend to drop out prematurely, or treatment is often unsuccessful [<xref ref-type="bibr" rid="ref5">5</xref>].</p>
      <p>Adolescents need a safe channel for sharing their concerns and feelings [<xref ref-type="bibr" rid="ref6">6</xref>]. Therefore, new treatment methods, such as Web-based interventions, need more attention. Web-based interventions have already been widely used among adolescents with depression [<xref ref-type="bibr" rid="ref7">7</xref>]. A commonly used therapeutic approach in these interventions is the cognitive behavioral therapy [<xref ref-type="bibr" rid="ref7">7</xref>-<xref ref-type="bibr" rid="ref9">9</xref>]. Besides structured mood tracking with validated instruments, Web-based interventions often include a variety of elements [<xref ref-type="bibr" rid="ref7">7</xref>], such as email remainders, diaries, discussion forums, or worksheets, focusing on goal setting, problem solving, and thought evaluation [<xref ref-type="bibr" rid="ref8">8</xref>]. On the other hand, multiple elements in interventions make it difficult to assess the elements that are most influential in increasing the effectiveness of the intervention [<xref ref-type="bibr" rid="ref7">7</xref>]. In addition, systematic and structured mood tracking does not allow adolescents to express their own emotions, feelings, or current concerns. Therefore, it may be valuable to assess how usable electronic diaries (e-diaries) are to adolescents in supporting them in expressing their burden using written and visual formats.</p>
      <p>In this study, an e-diary was used as a part of a Web-based intervention. We assumed that adolescents would be motivated to express their own perceptions of their life situation. Therefore, they had an opportunity to share their thoughts on specific weekly themes [<xref ref-type="bibr" rid="ref10">10</xref>]. At the same time, they had a chance to share their thoughts freely in the e-diary via expressive writing [<xref ref-type="bibr" rid="ref11">11</xref>]. Expressive writing is suitable for different therapeutic orientations [<xref ref-type="bibr" rid="ref11">11</xref>]. It has already been used as a treatment method in mental health [<xref ref-type="bibr" rid="ref11">11</xref>-<xref ref-type="bibr" rid="ref13">13</xref>] as well as for those people with depression and anxiety disorders [<xref ref-type="bibr" rid="ref14">14</xref>]. Writing can support a person as they approach their emotions or modulate the emotional intensity of those who may be less in touch with their emotions [<xref ref-type="bibr" rid="ref15">15</xref>]. Writing can also decrease stress and generate a desired change [<xref ref-type="bibr" rid="ref13">13</xref>].</p>
      <p>In general, diary writing can help adolescents to cope with numerous developmental challenges [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref15">15</xref>]. Diary writers describes or comments on an event that has happened and explores their feelings that occur almost simultaneously to writing in the diary [<xref ref-type="bibr" rid="ref16">16</xref>]. Diary writing can create a narrative of events, thoughts, hopes, and emotions. Writing in a diary can, therefore, be seen as the self-reflection of one’s own life [<xref ref-type="bibr" rid="ref17">17</xref>]. However, knowledge is still lacking on how a Web-based e-diary could be used for adolescents with depression. In this study, we aimed is to describe how adolescents with depressive symptoms use e-diary, which was a part of a Web-based program for adolescents with depression.</p>
      <p>This study is a substudy of the Depis.Net-study on the effectiveness of a Web-based intervention for adolescents with depression (ISRCTN80379583). The study included 6 adolescent psychiatry outpatient clinics at 2 Finnish University Hospitals, where psychiatric examination and treatment were offered to adolescents between 13 and 17 years of age. Data were gathered using the Depis.Net-program, developed at the University of Turku, Department of Nursing Science [<xref ref-type="bibr" rid="ref10">10</xref>]. The theoretical framework of the program is based on the self-determination theory [<xref ref-type="bibr" rid="ref18">18</xref>], and it is tailored to improve adolescents’ self-management skills and awareness of their own well-being and mental health [<xref ref-type="bibr" rid="ref10">10</xref>].</p>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Design</title>
        <p>A mixed-methods study design with quantitative and qualitative descriptive data [<xref ref-type="bibr" rid="ref19">19</xref>] was used to provide a deep understanding of the studied phenomena and the descriptive approach. In this study, the quantitative data were used to describe how adolescents used the e-diary, while the qualitative data were used to identify the contents adolescents discussed in their e-diaries. We assumed that using quantitative and qualitative approaches together will allow complementary information to arise—the quantitative data augmented the qualitative data, which were analyzed with the method of content analysis [<xref ref-type="bibr" rid="ref20">20</xref>]. The criteria of Tong et al [<xref ref-type="bibr" rid="ref21">21</xref>] were followed for reporting the qualitative data.</p>
      </sec>
      <sec>
        <title>Participants</title>
        <p>Participants (N=89) in this study were adolescents who were between 15 and 17 years of age at the time of obtaining informed consent. This study is a part of a two-arm randomized controlled trial (Depis.Net), and participants of this paper were adolescents who were randomized solely into an intervention group. The inclusion criteria for the randomized controlled trial were as follows: those aged 15-17 (at the time of recruitment) years and able to speak Finnish. Adolescents with serious mental disorders, such as psychotic depression, bipolar disorder, substance abuse, or a primary eating disorder, were excluded; those admitted to psychiatric hospital wards or involved in a brief intervention at an outpatient clinic (≤3 appointments) were also excluded. Participants in the intervention group were given personal identifiers (IDs) for logging into the Depis.Net program, which included an e-diary. They could use the program from any computer with internet access. We included in the analysis all potential participants of the intervention group who had an opportunity to use the e-diary.</p>
      </sec>
      <sec>
        <title>Data Collection</title>
        <p>Participants’ information, including their age, gender, education, previous use of mental health services, previous depression, and medication use during the last 6 months, was collected from medical records by nurses at the outpatient clinics. Outpatient clinic nurses assessed the overall severity of disturbance using the Children’s Global Assessment Scale (C-GAS) [<xref ref-type="bibr" rid="ref22">22</xref>]. Depressive symptoms were identified using the Beck Depression Inventory (BDI-21) [<xref ref-type="bibr" rid="ref23">23</xref>], which is a self-assessment instrument that has been validated for adolescents [<xref ref-type="bibr" rid="ref24">24</xref>].</p>
        <p>The Depis.Net intervention took 6 weeks—a 1-week introduction and 5 weeks during which themes changed weekly (well-being, home and family, adolescents’ rights and responsibilities, adolescent depression, and treatment of adolescents’ depression). The intervention also included health information, self-monitoring, and the use of e-diary where adolescents could reflect on their own life situation. The e-diary included technical instructions as well as personal writings that other adolescents could not see. Adolescents were given ideas related to the weekly theme, which aimed to support them in the use of the e-diary. They were asked to describe their current thoughts, feelings, and moods at least once a week, whenever they had time and the willingness to do so. They were also encouraged to use extra characters in the text, such as emoticons, pictures, song lyrics, or comics. They had access to material from all weeks and the e-diary during the 6-week program. It was possible to use the e-diary at any time within any week because the weeks did not close after they had been activated.</p>
        <p>To support adolescents in their use of the e-diary, supportive short message service (SMS) text messages were sent every Monday. They informed participants of the theme of that week. Feedback based on previous week was also offered to participants. In addition, those who had not used the e-diary by Thursday received an additional SMS text message to encourage them to write in it. Those who had used the e-diary during the week received feedback from the trained tutor through the program. Trained tutors read adolescents’ e-diary entries daily. If any severe concern was identified in an adolescent’s text, such as a threat of suicide, the trained tutors informed it to the responsible nurse or physician.</p>
      </sec>
      <sec>
        <title>Data Analysis</title>
        <p>Descriptive quantitative statistical methods (frequencies, averages) were used [<xref ref-type="bibr" rid="ref25">25</xref>], and qualitative data were analyzed using content analysis [<xref ref-type="bibr" rid="ref20">20</xref>]. First, using descriptive statistics, the content of e-diaries was described by how often and how much adolescents wrote and used pictures (eg, emoticons, combination of signs, photos, or drawings). The number of words was calculated, and the pictures were checked. For example, <italic>I should do lots of schoolwork at some point (I hate school &gt;:/</italic>  <italic>)....i.e. it seems in fact, that I have quite a lot of stress! </italic>  <italic>8O So typical &gt;_&lt;“”</italic> included 27 words and 3 pictures (<italic>&gt;:/, 8O, &gt;_&lt;“”</italic>). After this, an Excel table was generated to gather detailed information from 1 week at a time. The table was used to obtain a general overview of the 6-week period. The e-diary program made one automatic timestamp when an adolescent logged in. Automatic timestamps and the time of logging in were calculated. Background information on adolescents’ baseline characteristics and BDI-21 and C-GAS scores were analyzed by frequencies and percentages.</p>
        <p>Then, data were analyzed using inductive content analysis made from the manifest content. The sentence was used as a unit of analysis because, with smaller (word) or larger analysis units, the overall vision or some essential information could go unnoticed. For the inductive content analysis, printed e-diary entries were read a number of times to understand their content clearly. After this, the sentences that corresponded to the question “what issues have been addressed in the diaries” were manually highlighted [<xref ref-type="bibr" rid="ref20">20</xref>]. These sentences were transferred into a separate document and categorized by relevant phrases [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref26">26</xref>], which were coded (a coding phase) [<xref ref-type="bibr" rid="ref20">20</xref>]. The content of the e-diaries was then exported to the qualitative data analysis software, NVivo, where the coding of the sentences continued [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref27">27</xref>]. The codes and their content were compared to identify differences and similarities; subcategories were further formed. In the next step, these subcategories were abstracted and organized into categories based on the similarity of their content. A total of 7 subcategories were formed, which were further combined into 3 categories and named through reflection and discussions with the cowriters. [<xref ref-type="bibr" rid="ref20">20</xref>]</p>
        <p>To increase the validity of the analysis during the analysis process, the data were coded independently by 2 coders (KM and MK) and categories were formed by 3 authors (KM, MK, and MA) [<xref ref-type="bibr" rid="ref21">21</xref>]. Comments and thoughts were written in a notebook, which aimed to make the internal thinking visible. The notes also allowed the ideas related to the interpretation of the data to be revisited. Conclusions in all the phases were compared with the original data [<xref ref-type="bibr" rid="ref26">26</xref>].</p>
      </sec>
      <sec>
        <title>Ethical Issues</title>
        <p>The ethical approval was received from the ethics committee (#R08075H). Hospital administrators granted permissions to conduct the study. Good scientiﬁc practices [<xref ref-type="bibr" rid="ref28">28</xref>] and the principles for medical research and legislation [<xref ref-type="bibr" rid="ref29">29</xref>] were adhered to. The research assistants provided verbal and written information about the purpose and process of the study to adolescents. Adolescents’ participation in the trial was voluntary, and they gave written informed consent. It was possible to withdraw from the study without giving any reason, and it did not affect treatment. If there were severe concerns, such as suicidal ideation, a research assistant informed the responsible nurse or physician to ensure the safety of the adolescent. Anonymity was ensured by having personal access to the program only with a username and password. Unidentiﬁable codes (IDs) were used, and only the research assistants had access to the program. Anonymity was guaranteed in all phases of the study and reporting of the results. Printed e-diaries included only the unidentiﬁable IDs. They were stored in a locked space, and the e-diary texts were protected by passwords.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Characteristics of Electronic Diary Users</title>
        <p>Of the 89 participants, 47 used the e-diary. Almost all e-diary users were females. The majority of them were in high school compared to nonusers, many of whom were in a vocational school. More e-diary users had had previous episodes of depression. They had also used mental health services and medication more frequently than nonusers. According to BDI-21, more e-diary users had moderate or severe depression symptoms than nonusers. However, nonusers had slightly more serious problems in functioning (C-GAS) than did e-diary users. Characteristics of the e-diary users and nonusers are described in <xref ref-type="table" rid="table1">Table 1</xref>.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Characteristic of electronic diary users and nonusers.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="370"/>
            <col width="300"/>
            <col width="300"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Characteristics</td>
                <td>Users, n (%)</td>
                <td>Nonusers, n (%)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="4"><bold>Age (Years)</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>15</td>
                <td>16 (34)</td>
                <td>9 (22)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>16</td>
                <td>17 (36)</td>
                <td>21 (51)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>17</td>
                <td>13 (28)</td>
                <td>11 (27)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>18<sup>a</sup></td>
                <td>1 (2)</td>
                <td>0 (0%)</td>
              </tr>
              <tr valign="top">
                <td colspan="4"><bold>Gender</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Female</td>
                <td>45 (96)</td>
                <td>21 (51)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Male</td>
                <td>2 (4)</td>
                <td>20 (49)</td>
              </tr>
              <tr valign="top">
                <td colspan="4"><bold>Education</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Comprehensive school</td>
                <td>20 (43)</td>
                <td>18 (47)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>High school</td>
                <td>24 (51)</td>
                <td>9 (24)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Vocational school</td>
                <td>3 (6)</td>
                <td>11 (29)</td>
              </tr>
              <tr valign="top">
                <td colspan="4"><bold>Previous depression</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Yes</td>
                <td>32 (71)</td>
                <td>23 (61)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>No</td>
                <td>13 (29)</td>
                <td>15 (49)</td>
              </tr>
              <tr valign="top">
                <td colspan="4"><bold>Previous use of mental health services</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Yes</td>
                <td>32 (71)</td>
                <td>26 (68)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>No</td>
                <td>13 (29)</td>
                <td>12 (32)</td>
              </tr>
              <tr valign="top">
                <td colspan="4"><bold>Medication</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Yes</td>
                <td>21 (46)</td>
                <td>14 (37)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>No</td>
                <td>25 (54)</td>
                <td>24 (63)</td>
              </tr>
              <tr valign="top">
                <td colspan="4"><bold>Beck Depression Inventory 21 score</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>&lt;10</td>
                <td>5 (11)</td>
                <td>14 (34)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>10-16</td>
                <td>6 (13)</td>
                <td>10 (24)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>17-29</td>
                <td>19 (41)</td>
                <td>10 (24)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>30-63</td>
                <td>16 (35)</td>
                <td>7 (17)</td>
              </tr>
              <tr valign="top">
                <td colspan="4"><bold>Children’s Global Assessment Scale score</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>90-81</td>
                <td>1 (2)</td>
                <td>1 (3)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>80-71</td>
                <td>3 (6)</td>
                <td>6 (16)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>70-61</td>
                <td>18 (38)</td>
                <td>11 (30)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>60-51</td>
                <td>14 (30)</td>
                <td>7 (19)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>50-41</td>
                <td>10 (21)</td>
                <td>8 (22)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>40-31</td>
                <td>1 (2)</td>
                <td>4 (11)</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>Respondents who turned 18 years of age after the recruitment.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Usage of Electronic Diary</title>
        <p>Overall, 53% (47/89) of the participants used the e-diary during data collection. Most of the adolescents (16/47, 34%) logged into the e-diary within 2 weeks, and 21% (10/47) logged into the e-diary at least once during each of the 5 weeks. The adolescents logged into the program a total of 147 times (range 1-13 times; median 2; mean 3.1, SD 2.3). Most adolescents (39/47, 83%) logged into the e-diary during the first week, and over half (27/47, 57%) of the e-diary logs were made during the 2 first weeks. In addition, 21% (10/47) of the adolescents relogged into their e-diary and modified or added their output later. Nearly all (22766/22855, 99.61%) of the e-diary logs were made using text form (words), while pictures were rarely used (89/22855, 0.39%). The most logged themes, based on the number of log-ins, were “well-being” and “adolescents rights and responsibilities” (<xref ref-type="table" rid="table2">Table 2</xref>). The number of words used ranged from 8 to 1442 per each log (mean 174.2, SD 204.4).</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Usage of the electronic diary within 1 week and all 5 weeks.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="350"/>
            <col width="140"/>
            <col width="140"/>
            <col width="170"/>
            <col width="200"/>
            <thead>
              <tr valign="top">
                <td>Topic</td>
                <td>Words (n=22,766), n (%)</td>
                <td>Pictures (n=89), n (%)</td>
                <td>Total (N=22,855), n (%)</td>
                <td>Logging frequency (N=147), n (%)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Well-being</td>
                <td>8081 (35.50)</td>
                <td>23 (25.84)</td>
                <td>8104 (35.46)</td>
                <td>51 (35.70)</td>
              </tr>
              <tr valign="top">
                <td>Home and family</td>
                <td>4286 (18.83)</td>
                <td>20 (22.47)</td>
                <td>4306 (18.84)</td>
                <td>33 (22.45)</td>
              </tr>
              <tr valign="top">
                <td>Adolescents rights and responsibilities</td>
                <td>4877 (21.42)</td>
                <td>29 (32.58)</td>
                <td>4906 (21.47)</td>
                <td>24 (16.33)</td>
              </tr>
              <tr valign="top">
                <td>Adolescent depression</td>
                <td>2742 (12.04)</td>
                <td>5 (5.62)</td>
                <td>2747 (12.02)</td>
                <td>21 (14.29)</td>
              </tr>
              <tr valign="top">
                <td>Treatment of adolescents’ depression</td>
                <td>2780 (12.21)</td>
                <td>12 (13.48)</td>
                <td>2792 (12.22)</td>
                <td>18 (12.24)</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>Logging days and hours.</p>
          </caption>
          <graphic xlink:href="jmir_v21i2e11711_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <p>Sundays to Tuesdays were the most common days for writing in the e-diary, and evenings were the most common time of the day (<xref ref-type="fig" rid="figure1">Figure 1</xref>). Adolescents did not use the e-diary at all after 2 am. Logs made in the program at night time (from 23 pm to 2 am) or in the mornings (from 09 am to 12 pm) were also very limited.</p>
      </sec>
      <sec>
        <title>Topics of the Electronic Diary</title>
        <p>In this study, 3 main categories were formed to represent the topics of the adolescents’ e-diaries—mental disorder, relationship, and identity (<xref ref-type="table" rid="table3">Table 3</xref>).</p>
        <sec>
          <title>Mental Disorder</title>
          <p>Adolescents discussed and described their symptoms of mental disorder, for example, self-mutilation, substance abuse, and eating problems. They also discussed the destructive thoughts that reflected their moods and maintained their symptoms. They discussed how mental disorder and fatigue decreased their functional and coping capacity. Adolescents described themselves being alone and alienated from others.</p>
          <p>They wrote about outpatient care, medication, and how they had tried to help themselves. They highlighted that they feel easier when they have succeeded in adjusting their own thoughts. For example, writing and making e-diary entries in the program were mentioned as helping to clarify feelings and thoughts. Adolescents described different kinds of self-help methods, with which they had tried to find solutions to their mental health problems and improve their well-being. Even though they pointed out what might help them, they wrote that they do not know or have not found ways to obtain relief from mental disorders; there was understanding as to what would help but no strength to accomplish it. They expressed that the things that could help to dissolve bad feeling can also cause them, for example, music or writing.</p>
          <p>Adolescents expressed their hope of recovery from mental disorder. They described how they had experienced positive changes that had occurred within their mental health. However, there were descriptions of despondency about never getting better.</p>
          <table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Topics of the electronic diary.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="190"/>
            <col width="190"/>
            <col width="590"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Main category</td>
                <td>Code</td>
                <td>Expression<sup>a</sup></td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="4"><bold>Mental disorder</bold></td>
              </tr>
              <tr valign="top">
                <td rowspan="12"><break/></td>
                <td rowspan="5">Symptoms</td>
                <td>Self-harm</td>
                <td>I took some scissors and cut long wounds in my legs. (ID<sup>b</sup> 431)</td>
              </tr>
              <tr valign="top">
                <td>Suicidal thoughts</td>
                <td>I now have fewer thoughts of suicide. I still think about it, but not all the time. (ID 439)</td>
              </tr>
              <tr valign="top">
                <td>Tiredness</td>
                <td>When I am tired and start thinking about problems, I feel bad. (ID 5)</td>
              </tr>
              <tr valign="top">
                <td>Loneliness</td>
                <td>I feel lonely when I am with my friends, like I'm in a bubble. (ID 116)</td>
              </tr>
              <tr valign="top">
                <td>Distress</td>
                <td>I can’t find time to relax, or if I have a free moment, I get stressed because I know that there is still school work or something else to be done. This depression never ends. (ID 299)</td>
              </tr>
              <tr valign="top">
                <td rowspan="5">Treatment</td>
                <td>Outpatient care</td>
                <td>After the conversation /with the nurse/ my thoughts went from a blob to well-structured body. (ID 79)</td>
              </tr>
              <tr valign="top">
                <td>Medication</td>
                <td>Compared to the previous weeks I feel better. Probably because the doctor increased my night drugs. (ID 357)</td>
              </tr>
              <tr valign="top">
                <td rowspan="3">Self-help</td>
                <td>I can write more. This is very relieving. Surprisingly so. I can deal with my thoughts. (ID 290)</td>
              </tr>
              <tr valign="top">
                <td>Music always makes me feel both good and bad feelings. (ID 508)</td>
              </tr>
              <tr valign="top">
                <td>I've been thinking a lot and have tried many ways to get rid of this bad feeling, but I haven’t really found help. (ID 299)</td>
              </tr>
              <tr valign="top">
                <td rowspan="2">Recovery</td>
                <td>Hope</td>
                <td>Five years from now, I hope I will be a healthy young woman. (ID 475)</td>
              </tr>
              <tr valign="top">
                <td>Despondency</td>
                <td>I feel like I’m not getting better and therefore I can’t imagine my future. (ID 438)</td>
              </tr>
              <tr valign="top">
                <td colspan="4"><bold>Relationship</bold></td>
              </tr>
              <tr valign="top">
                <td rowspan="7"><break/></td>
                <td rowspan="3">Supportive</td>
                <td>Resource of everyday life</td>
                <td>Family, friends, and schoolmates can be a resource. (ID 8)</td>
              </tr>
              <tr valign="top">
                <td rowspan="2">Reciprocity</td>
                <td>Typically, I am the one who listens to others’ problems. Sometimes I’d like for my friends to listen to me, to how I feel. (ID 440)</td>
              </tr>
              <tr valign="top">
                <td>I was active at school (I don’t usually speak during lessons, just with friends during breaks), and I even spoke with my classmates. (ID 26)</td>
              </tr>
              <tr valign="top">
                <td rowspan="4">Nonsupportive</td>
                <td rowspan="2">Bullying</td>
                <td>I have experienced so many different things in my circle of friends, I’ve been insulted, discriminated against and, bullied in every possible way. (ID 499)</td>
              </tr>
              <tr valign="top">
                <td>I’m afraid to bring my own opinions into the classroom because everyone would laugh. (ID 475)</td>
              </tr>
              <tr valign="top">
                <td rowspan="2">Conflicts</td>
                <td>On Saturday morning was terrible, my dad complained to me about everything and I cried and told him that I did my best and my mum tried to calm him down. (ID 431)</td>
              </tr>
              <tr valign="top">
                <td>When my mum is normal it is much easier to be at home. (ID 64)</td>
              </tr>
              <tr valign="top">
                <td colspan="4"><bold>Identity</bold></td>
              </tr>
              <tr valign="top">
                <td rowspan="4"><break/></td>
                <td rowspan="4">Ego development</td>
                <td>Temporal changes</td>
                <td>For almost two years my self-esteem has been higher, because I learned not to think too much about others’ opinions. (ID 436)</td>
              </tr>
              <tr valign="top">
                <td>Strengths</td>
                <td>Before, around age 9-12, I had self-esteem problems, but I got over them quite well. (ID 100)</td>
              </tr>
              <tr valign="top">
                <td>Weaknesses</td>
                <td>I consider myself to be a weak person. Vulnerable, small, pathetic. (ID 449)</td>
              </tr>
              <tr valign="top">
                <td>Capacities</td>
                <td>I like my way of thinking; my positivity also shows. (ID 116)</td>
              </tr>
              <tr valign="top">
                <td rowspan="2"><break/></td>
                <td rowspan="2">Future expectations</td>
                <td>Dreams</td>
                <td>My plans and dreams cover just the next two years, and during that time I want to go to USA and get a dog and an apartment. And I want to be HAPPY. (ID 147)</td>
              </tr>
              <tr valign="top">
                <td>Fears</td>
                <td>I think that all my dreams have been crushed, and I don’t expect anything from the future. (ID 120)</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table3fn1">
              <p><sup>a</sup>Translated from Finnish.</p>
            </fn>
            <fn id="table3fn2">
              <p><sup>b</sup>ID: Identifier.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        </sec>
        <sec>
          <title>Relationship</title>
          <p>Adolescents described their involvement in relationships in different situations and events in their communities such as at home, at school, and during leisure-time activities. They discussed their interpersonal relationships with family members, friends, peers, and loved ones. In these writings, adolescents described how they had acted or what had happened, and how relationships have influenced their experience of their environment. In other words, adolescents discussed and described how they feel in different situations with different people.</p>
          <p>The nature of relationships was described as being supportive or demanding depending on the behavior and its interpretation. Adolescents expressed the fact that supportive relationships were important resources in everyday life. At the same time, one major fear was losing someone, especially a loved one. They also discussed reciprocity in relationships, how it worked at its best, and what hindered it.</p>
          <p>Demanding relationships were discussed in bullying situations and with different kind of difficulties and conflicts with people. Experiences of bullying by friends and schoolmates were described. Conflicts and problems were pointed out, especially with family members. In addition, conflicts with friends and schoolmates were mentioned. Adolescents discussed explanations for these conflicts as being the interpretations of interaction situations, and they discussed how their own and other people’s behavior affect how they interact with other people.</p>
        </sec>
        <sec>
          <title>Identity</title>
          <p>Adolescents discussed their ego development by reflecting on how temporal changes had influenced the way they see themselves and their abilities. They described and discussed their positive and negative self-experiences. Positive expressions were related to adolescents’ strengths and things they liked about themselves. Negative expressions were related to weaknesses and things they did not like about themselves; in these writings, adolescents revealed dissatisfaction and difficulty with accepting themselves. They also considered their capacities to reflect on how the experience of oneself was related to the opinions of others and how these opinions affect them. It emerged that thinking of others’ opinions undermines self-esteem.</p>
          <p>Adolescents wrote about their future expectations, for example, what kind of person they would like to be. Future dreams were related to education, work, having their own home and family. Beside this, there were fears expressed about a future in which dreams and aspirations seemed distant or impossible to achieve.</p>
        </sec>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>In this study, we assumed that e-diary writing might be a usable tool for reflecting thoughts for those who have depressive symptoms. Indeed, adolescents included different topics in their e-diaries. They described and discussed negative and positive events in their lives as well as difficulties and good experiences. They also pointed out their hopes and concerns [<xref ref-type="bibr" rid="ref6">6</xref>] about their future and recovery from mental disorder. Despite the structure and content of the weekly program, adolescents had the chance to bring up concerns and other issues that were important to them, regardless of the week session. We can therefore assume that the instruction of the e-diary supported, but did not restrict, adolescents in dealing with important issues in e-diaries.</p>
        <p>On the other hand, 47% (42/89) of the participants did not use the e-diary at all. About one-third (19/47, 40%) logged into the e-diary each week. Välimäki et al [<xref ref-type="bibr" rid="ref7">7</xref>], in their systematic review and meta-analysis, have identified high dropout rates in Web-based interventions for adolescents. Reasons for low usage in Web-based interventions remain unknown. First, we can assume that adolescents simply may not like to use Web-based interventions because they are out of date or they do not meet their expectations. Second, there is some evidence that young girls in particular prefer to use the internet and smartphone apps for social communication and entertainment but not for purposes related to mental health [<xref ref-type="bibr" rid="ref9">9</xref>]. Third, adolescents who did not log into the e-diary may have been reluctant to do so if they did not experience any advantage in writing or if they had a fear of disclosing painful or difficult topics [<xref ref-type="bibr" rid="ref11">11</xref>]. Fourth, as shown in a previous study [<xref ref-type="bibr" rid="ref12">12</xref>], adolescents with depression may also have difficulties with motivation and concentration, and they may have found Web-based intervention rather demanding. On the other hand, we found in this study that e-diary users more often had a history of depression and previous experience of mental health care services, and their depressive symptoms were more severe compared with those of nonusers. We can therefore assume that, despite burdening depressive symptoms, young people may find an e-diary useful.</p>
        <p>We still found that boys were in a clear minority (2/47, 4%) when it came to writing in the e-diary. This is surprising because boys are active users of information technology. On the other hand, diary keeping is a more common habit for girls, especially at the age of 14-15 years [<xref ref-type="bibr" rid="ref15">15</xref>]. To satisfy boys’ needs for technology use, more action and gaming elements might be more usable for young male participants. We assumed at the beginning of the study that adolescents might be reluctant to continue the intervention. Therefore, we sent them reminder SMS text messages and supportive feedback to encourage and motivate their program use [<xref ref-type="bibr" rid="ref10">10</xref>]. Despite the SMS text message reminder, we found that both participation and e-diary entries decreased after the first week. We can, therefore, assume that SMS text messages did not have much value in supporting adolescents’ participation, although a more recent study with adults has showed that participants preferred receiving SMS text message reminders on Mondays and that they preferred slightly humorous SMS text messages [<xref ref-type="bibr" rid="ref30">30</xref>]. It is also possible that the feedback and SMS text messages were not supportive enough. Gender may also be one explanation since intervention dropouts have previously more often been among women rather than men [<xref ref-type="bibr" rid="ref31">31</xref>]. While participants’ engagement is an important factor for Web-based interventions [<xref ref-type="bibr" rid="ref23">23</xref>], more studies are still needed to determine whether participation in electronic health applications could be increased [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref32">32</xref>]. In future, it would be important to explore whether enhancing real-time support [<xref ref-type="bibr" rid="ref23">23</xref>] can increase engagement in the Web-based interventions.</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>This study has limitations that should be taken into consideration. First, the data were limited because the number of nonusers increased during the follow-up. Second, the data were collected during 2008-2010, and it could be questioned whether the data are still up to date. However, writing diary entries has a long history, and generally, as in this study, it includes descriptions or comments about events that occur or will occur at about the same time as they are written about [<xref ref-type="bibr" rid="ref16">16</xref>]. Therefore, we can assume that these data provide us relevant knowledge about topics that concern the minds of adolescents.</p>
        <p>On the other hand, technology use has been developed during the last decade, especially mobile technology. If a mobile version of the e-diary was used in this study, the number and time of logs could be different [<xref ref-type="bibr" rid="ref33">33</xref>]. Third, e-diary entries were written in Finnish, and they represent the quite homogenous nature of Finnish culture. Therefore, the results of this study may not be culturally generalizable. Even so, writing in itself is beneficial for ethnically diverse groups and with a broad spectrum of people, including those who are less socially, academically, or physically advantaged [<xref ref-type="bibr" rid="ref34">34</xref>]. In general, the results can therefore be valuable in different lingual and cultural regions when engaging Web-based interventions are being designed for young people with mental health problems.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>Not all adolescents in this study were willing to use the e-diary to express their emotions or feelings [<xref ref-type="bibr" rid="ref7">7</xref>]. We also found that adolescents who used the e-diary were more often girls and had current or previous experiences of depression and mental health care services. These adolescents were willing to describe their thoughts about mental health problems and their need for recovery. They also had the ability to reflect on their thoughts in writing, which was supported by specific themes. For future purposes, it is important to explore the reasons for nonuse and suspensions as well as how to support engagement in Web-based interventions.</p>
        <p>We are already aware that Web-based interventions with structured monitoring are effective for adolescents with depression [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref9">9</xref>]. Based on this study, we can only assume that an e-diary with an element of expressive writing may have an additional value for some young people, especially for girls, to help them reflect their own thoughts and feelings about their burdening situation. On the other hand, the methods could not reach young boys, who still need more engaging technology where they can share their thoughts, feelings, and moods. In general, participant engagement is an important factor for Web-based interventions [<xref ref-type="bibr" rid="ref23">23</xref>]. More studies are still needed to identify how participant engagement in Web-based interventions could be supported [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref32">32</xref>]. Results of this study can still be used to develop user-centered electronic health applications, which can allow users to express their own thoughts and feelings in ways other than systematic mood monitoring.</p>
      </sec>
    </sec>
  </body>
  <back>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">BDI-21</term>
          <def>
            <p>Beck Depression Inventory-21</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">C-GAS</term>
          <def>
            <p>Children’s Global Assessment Scale</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">e-diary</term>
          <def>
            <p>electronic diary</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">ID</term>
          <def>
            <p>identifier</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">SMS</term>
          <def>
            <p>short message service</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This study was funded by the Academy of Finland (#8214245), The Hospital District of Southwest Finland (#13893), The Paulo Foundation, the Finnish Cultural Foundation, the Yrjö Jahnsson Foundation (#5920), and the Foundations’ Professor Pool.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Merikangas</surname>
            <given-names>KR</given-names>
          </name>
          <name name-style="western">
            <surname>Nakamura</surname>
            <given-names>EF</given-names>
          </name>
          <name name-style="western">
            <surname>Kessler</surname>
            <given-names>RC</given-names>
          </name>
        </person-group>
        <article-title>Epidemiology of mental disorders in children and adolescents</article-title>
        <source>Dialogues in clinical neuroscience</source>  
        <year>2009</year>  
        <volume>11</volume>  
        <issue>1</issue>  
        <fpage>7</fpage>  
        <lpage>20</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/19432384"/>
        </comment>  
        <pub-id pub-id-type="medline">19432384</pub-id>
        <pub-id pub-id-type="pmcid">PMC2807642</pub-id></nlm-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Thapar</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Collishaw</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Pine</surname>
            <given-names>DS</given-names>
          </name>
          <name name-style="western">
            <surname>Thapar</surname>
            <given-names>AK</given-names>
          </name>
        </person-group>
        <article-title>Depression in adolescence</article-title>
        <source>Lancet</source>  
        <year>2012</year>  
        <month>03</month>  
        <day>17</day>  
        <volume>379</volume>  
        <issue>9820</issue>  
        <fpage>1056</fpage>  
        <lpage>67</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/22305766"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1016/S0140-6736(11)60871-4</pub-id>
        <pub-id pub-id-type="medline">22305766</pub-id>
        <pub-id pub-id-type="pii">S0140-6736(11)60871-4</pub-id>
        <pub-id pub-id-type="pmcid">PMC3488279</pub-id></nlm-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Gladstone</surname>
            <given-names>TG</given-names>
          </name>
          <name name-style="western">
            <surname>Marko-Holguin</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Rothberg</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Nidetz</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Diehl</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>DeFrino</surname>
            <given-names>DT</given-names>
          </name>
          <name name-style="western">
            <surname>Harris</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Ching</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Eder</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Canel</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Bell</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Beardslee</surname>
            <given-names>WR</given-names>
          </name>
          <name name-style="western">
            <surname>Brown</surname>
            <given-names>CH</given-names>
          </name>
          <name name-style="western">
            <surname>Griffiths</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Van Voorhees</surname>
            <given-names>Benjamin W</given-names>
          </name>
        </person-group>
        <article-title>An internet-based adolescent depression preventive intervention: study protocol for a randomized control trial</article-title>
        <source>Trials</source>  
        <year>2015</year>  
        <month>05</month>  
        <day>01</day>  
        <volume>16</volume>  
        <fpage>203</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-015-0705-2"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1186/s13063-015-0705-2</pub-id>
        <pub-id pub-id-type="medline">25927539</pub-id>
        <pub-id pub-id-type="pii">10.1186/s13063-015-0705-2</pub-id>
        <pub-id pub-id-type="pmcid">PMC4418055</pub-id></nlm-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Costello</surname>
            <given-names>EJ</given-names>
          </name>
          <name name-style="western">
            <surname>He</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Sampson</surname>
            <given-names>NA</given-names>
          </name>
          <name name-style="western">
            <surname>Kessler</surname>
            <given-names>RC</given-names>
          </name>
          <name name-style="western">
            <surname>Merikangas</surname>
            <given-names>KR</given-names>
          </name>
        </person-group>
        <article-title>Services for adolescents with psychiatric disorders: 12-month data from the National Comorbidity Survey-Adolescent</article-title>
        <source>Psychiatr Serv</source>  
        <year>2014</year>  
        <month>03</month>  
        <day>01</day>  
        <volume>65</volume>  
        <issue>3</issue>  
        <fpage>359</fpage>  
        <lpage>66</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/24233052"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1176/appi.ps.201100518</pub-id>
        <pub-id pub-id-type="medline">24233052</pub-id>
        <pub-id pub-id-type="pii">1777606</pub-id>
        <pub-id pub-id-type="pmcid">PMC4123755</pub-id></nlm-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Harpaz-Rotem</surname>
            <given-names>I</given-names>
          </name>
          <name name-style="western">
            <surname>Leslie</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Rosenheck</surname>
            <given-names>RA</given-names>
          </name>
        </person-group>
        <article-title>Treatment retention among children entering a new episode of mental health care</article-title>
        <source>Psychiatr Serv</source>  
        <year>2004</year>  
        <month>09</month>  
        <volume>55</volume>  
        <issue>9</issue>  
        <fpage>1022</fpage>  
        <lpage>8</lpage>  
        <pub-id pub-id-type="doi">10.1176/appi.ps.55.9.1022</pub-id>
        <pub-id pub-id-type="medline">15345762</pub-id>
        <pub-id pub-id-type="pii">55/9/1022</pub-id></nlm-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Anttila</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Anttila</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Kurki</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Hätönen</surname>
            <given-names>H</given-names>
          </name>
          <name name-style="western">
            <surname>Marttunen</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Välimäki</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>Concerns and hopes among adolescents attending adolescent psychiatric outpatient clinics</article-title>
        <source>Child Adolesc Ment Health</source>  
        <year>2014</year>  
        <month>08</month>  
        <day>13</day>  
        <volume>20</volume>  
        <issue>2</issue>  
        <fpage>81</fpage>  
        <lpage>88</lpage>  
        <pub-id pub-id-type="doi">10.1111/camh.12074</pub-id></nlm-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Välimäki</surname>
            <given-names>Maritta</given-names>
          </name>
          <name name-style="western">
            <surname>Anttila</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Anttila</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Lahti</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>Web-Based Interventions Supporting Adolescents and Young People With Depressive Symptoms: Systematic Review and Meta-Analysis</article-title>
        <source>JMIR Mhealth Uhealth</source>  
        <year>2017</year>  
        <month>12</month>  
        <day>08</day>  
        <volume>5</volume>  
        <issue>12</issue>  
        <fpage>e180</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://mhealth.jmir.org/2017/12/e180/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/mhealth.8624</pub-id>
        <pub-id pub-id-type="medline">29222079</pub-id>
        <pub-id pub-id-type="pii">v5i12e180</pub-id>
        <pub-id pub-id-type="pmcid">PMC5741826</pub-id></nlm-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Renton</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Tang</surname>
            <given-names>H</given-names>
          </name>
          <name name-style="western">
            <surname>Ennis</surname>
            <given-names>N</given-names>
          </name>
          <name name-style="western">
            <surname>Cusimano</surname>
            <given-names>MD</given-names>
          </name>
          <name name-style="western">
            <surname>Bhalerao</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Schweizer</surname>
            <given-names>TA</given-names>
          </name>
          <name name-style="western">
            <surname>Topolovec-Vranic</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>Web-based intervention programs for depression: a scoping review and evaluation</article-title>
        <source>J Med Internet Res</source>  
        <year>2014</year>  
        <month>09</month>  
        <day>23</day>  
        <volume>16</volume>  
        <issue>9</issue>  
        <fpage>e209</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://www.jmir.org/2014/9/e209/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.3147</pub-id>
        <pub-id pub-id-type="medline">25249003</pub-id>
        <pub-id pub-id-type="pii">v16i9e209</pub-id>
        <pub-id pub-id-type="pmcid">PMC4211022</pub-id></nlm-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Stasiak</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Fleming</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Lucassen</surname>
            <given-names>MFG</given-names>
          </name>
          <name name-style="western">
            <surname>Shepherd</surname>
            <given-names>MJ</given-names>
          </name>
          <name name-style="western">
            <surname>Whittaker</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Merry</surname>
            <given-names>SN</given-names>
          </name>
        </person-group>
        <article-title>Computer-Based and Online Therapy for Depression and Anxiety in Children and Adolescents</article-title>
        <source>J Child Adolesc Psychopharmacol</source>  
        <year>2016</year>  
        <month>04</month>  
        <volume>26</volume>  
        <issue>3</issue>  
        <fpage>235</fpage>  
        <lpage>45</lpage>  
        <pub-id pub-id-type="doi">10.1089/cap.2015.0029</pub-id>
        <pub-id pub-id-type="medline">26465266</pub-id></nlm-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Välimäki</surname>
            <given-names>Maritta</given-names>
          </name>
          <name name-style="western">
            <surname>Kurki</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Hätönen</surname>
            <given-names>Heli</given-names>
          </name>
          <name name-style="western">
            <surname>Koivunen</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Selander</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Saarijärvi</surname>
            <given-names>Simo</given-names>
          </name>
          <name name-style="western">
            <surname>Anttila</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>Developing an internet-based support system for adolescents with depression</article-title>
        <source>JMIR Res Protoc</source>  
        <year>2012</year>  
        <month>12</month>  
        <day>12</day>  
        <volume>1</volume>  
        <issue>2</issue>  
        <fpage>e22</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://www.researchprotocols.org/2012/2/e22/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/resprot.2263</pub-id>
        <pub-id pub-id-type="medline">23612485</pub-id>
        <pub-id pub-id-type="pii">v1i2e22</pub-id>
        <pub-id pub-id-type="pmcid">PMC3626154</pub-id></nlm-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Cummings</surname>
            <given-names>JA</given-names>
          </name>
          <name name-style="western">
            <surname>Hayes</surname>
            <given-names>AM</given-names>
          </name>
          <name name-style="western">
            <surname>Saint</surname>
            <given-names>DS</given-names>
          </name>
          <name name-style="western">
            <surname>Park</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>Expressive writing in psychotherapy: A tool to promote and track therapeutic change</article-title>
        <source>Professional Psychology: Research and Practice</source>  
        <year>2014</year>  
        <volume>45</volume>  
        <issue>5</issue>  
        <fpage>378</fpage>  
        <lpage>386</lpage>  
        <pub-id pub-id-type="doi">10.1037/a0037682</pub-id></nlm-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Baikie</surname>
            <given-names>KA</given-names>
          </name>
          <name name-style="western">
            <surname>Geerligs</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>Wilhelm</surname>
            <given-names>K</given-names>
          </name>
        </person-group>
        <article-title>Expressive writing and positive writing for participants with mood disorders: an online randomized controlled trial</article-title>
        <source>J Affect Disord</source>  
        <year>2012</year>  
        <month>02</month>  
        <volume>136</volume>  
        <issue>3</issue>  
        <fpage>310</fpage>  
        <lpage>9</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.jad.2011.11.032</pub-id>
        <pub-id pub-id-type="medline">22209127</pub-id>
        <pub-id pub-id-type="pii">S0165-0327(11)00749-X</pub-id></nlm-citation>
      </ref>
      <ref id="ref13">
        <label>13</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Boniel-Nissim</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Barak</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <article-title>The therapeutic value of adolescents' blogging about social-emotional difficulties</article-title>
        <source>Psychol Serv</source>  
        <year>2013</year>  
        <month>08</month>  
        <volume>10</volume>  
        <issue>3</issue>  
        <fpage>333</fpage>  
        <lpage>41</lpage>  
        <pub-id pub-id-type="doi">10.1037/a0026664</pub-id>
        <pub-id pub-id-type="medline">23937092</pub-id>
        <pub-id pub-id-type="pii">2011-28639-001</pub-id></nlm-citation>
      </ref>
      <ref id="ref14">
        <label>14</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Kerner</surname>
            <given-names>EA</given-names>
          </name>
          <name name-style="western">
            <surname>Fitzpatrick</surname>
            <given-names>MR</given-names>
          </name>
        </person-group>
        <article-title>Integrating writing into psychotherapy practice: A matrix of change processes and structural dimensions</article-title>
        <source>Psychotherapy (Chic)</source>  
        <year>2007</year>  
        <month>09</month>  
        <volume>44</volume>  
        <issue>3</issue>  
        <fpage>333</fpage>  
        <lpage>46</lpage>  
        <pub-id pub-id-type="doi">10.1037/0033-3204.44.3.333</pub-id>
        <pub-id pub-id-type="medline">22122259</pub-id>
        <pub-id pub-id-type="pii">2007-14639-016</pub-id></nlm-citation>
      </ref>
      <ref id="ref15">
        <label>15</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Seiffge-Krenke</surname>
            <given-names>I</given-names>
          </name>
        </person-group>
        <article-title>Imaginary companions in adolescence: sign of a deficient or positive development</article-title>
        <source>J Adolesc</source>  
        <year>1997</year>  
        <month>04</month>  
        <volume>20</volume>  
        <issue>2</issue>  
        <fpage>137</fpage>  
        <lpage>54</lpage>  
        <pub-id pub-id-type="doi">10.1006/jado.1996.0072</pub-id>
        <pub-id pub-id-type="medline">9104650</pub-id>
        <pub-id pub-id-type="pii">S0140-1971(96)90072-X</pub-id></nlm-citation>
      </ref>
      <ref id="ref16">
        <label>16</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Cucu-Oancea</surname>
            <given-names>O</given-names>
          </name>
        </person-group>
        <article-title>Using Diaries - A Real Challenge for the Social Scientist</article-title>
        <source>Procedia - Social and Behavioral Sciences</source>  
        <year>2013</year>  
        <month>10</month>  
        <volume>92</volume>  
        <fpage>231</fpage>  
        <lpage>238</lpage>  
        <pub-id pub-id-type="doi">10.1016/J.SBSPRO.2013.08.665</pub-id></nlm-citation>
      </ref>
      <ref id="ref17">
        <label>17</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Travers</surname>
            <given-names>C</given-names>
          </name>
        </person-group>
        <article-title>Unveiling a reflective diary methodology for exploring the lived experiences of stress and coping</article-title>
        <source>Journal of Vocational Behavior</source>  
        <year>2011</year>  
        <month>08</month>  
        <volume>79</volume>  
        <issue>1</issue>  
        <fpage>204</fpage>  
        <lpage>216</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.jvb.2010.11.007</pub-id></nlm-citation>
      </ref>
      <ref id="ref18">
        <label>18</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ryan</surname>
            <given-names>RM</given-names>
          </name>
          <name name-style="western">
            <surname>Deci</surname>
            <given-names>EL</given-names>
          </name>
        </person-group>
        <article-title>Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being</article-title>
        <source>Am Psychol</source>  
        <year>2000</year>  
        <month>01</month>  
        <volume>55</volume>  
        <issue>1</issue>  
        <fpage>68</fpage>  
        <lpage>78</lpage>  
        <pub-id pub-id-type="medline">11392867</pub-id></nlm-citation>
      </ref>
      <ref id="ref19">
        <label>19</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Kettles</surname>
            <given-names>AM</given-names>
          </name>
          <name name-style="western">
            <surname>Creswell</surname>
            <given-names>JW</given-names>
          </name>
          <name name-style="western">
            <surname>Zhang</surname>
            <given-names>W</given-names>
          </name>
        </person-group>
        <article-title>Mixed methods research in mental health nursing</article-title>
        <source>J Psychiatr Ment Health Nurs</source>  
        <year>2011</year>  
        <month>08</month>  
        <volume>18</volume>  
        <issue>6</issue>  
        <fpage>535</fpage>  
        <lpage>42</lpage>  
        <pub-id pub-id-type="doi">10.1111/j.1365-2850.2011.01701.x</pub-id>
        <pub-id pub-id-type="medline">21749560</pub-id></nlm-citation>
      </ref>
      <ref id="ref20">
        <label>20</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Graneheim</surname>
            <given-names>UH</given-names>
          </name>
          <name name-style="western">
            <surname>Lundman</surname>
            <given-names>B</given-names>
          </name>
        </person-group>
        <article-title>Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness</article-title>
        <source>Nurse Educ Today</source>  
        <year>2004</year>  
        <month>02</month>  
        <volume>24</volume>  
        <issue>2</issue>  
        <fpage>105</fpage>  
        <lpage>12</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.nedt.2003.10.001</pub-id>
        <pub-id pub-id-type="medline">14769454</pub-id>
        <pub-id pub-id-type="pii">S0260691703001515</pub-id></nlm-citation>
      </ref>
      <ref id="ref21">
        <label>21</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Tong</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Sainsbury</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Craig</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups</article-title>
        <source>Int J Qual Health Care</source>  
        <year>2007</year>  
        <month>12</month>  
        <volume>19</volume>  
        <issue>6</issue>  
        <fpage>349</fpage>  
        <lpage>57</lpage>  
        <pub-id pub-id-type="doi">10.1093/intqhc/mzm042</pub-id>
        <pub-id pub-id-type="medline">17872937</pub-id>
        <pub-id pub-id-type="pii">mzm042</pub-id></nlm-citation>
      </ref>
      <ref id="ref22">
        <label>22</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Palmqvist</surname>
            <given-names>B</given-names>
          </name>
          <name name-style="western">
            <surname>Carlbring</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Andersson</surname>
            <given-names>G</given-names>
          </name>
        </person-group>
        <article-title>Internet-delivered treatments with or without therapist input: does the therapist factor have implications for efficacy and cost?</article-title>
        <source>Expert Rev Pharmacoecon Outcomes Res</source>  
        <year>2007</year>  
        <month>06</month>  
        <volume>7</volume>  
        <issue>3</issue>  
        <fpage>291</fpage>  
        <lpage>7</lpage>  
        <pub-id pub-id-type="doi">10.1586/14737167.7.3.291</pub-id>
        <pub-id pub-id-type="medline">20528315</pub-id></nlm-citation>
      </ref>
      <ref id="ref23">
        <label>23</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Rice</surname>
            <given-names>SM</given-names>
          </name>
          <name name-style="western">
            <surname>Goodall</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Hetrick</surname>
            <given-names>SE</given-names>
          </name>
          <name name-style="western">
            <surname>Parker</surname>
            <given-names>AG</given-names>
          </name>
          <name name-style="western">
            <surname>Gilbertson</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Amminger</surname>
            <given-names>GP</given-names>
          </name>
          <name name-style="western">
            <surname>Davey</surname>
            <given-names>CG</given-names>
          </name>
          <name name-style="western">
            <surname>McGorry</surname>
            <given-names>PD</given-names>
          </name>
          <name name-style="western">
            <surname>Gleeson</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Alvarez-Jimenez</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>Online and social networking interventions for the treatment of depression in young people: a systematic review</article-title>
        <source>J Med Internet Res</source>  
        <year>2014</year>  
        <month>09</month>  
        <day>16</day>  
        <volume>16</volume>  
        <issue>9</issue>  
        <fpage>e206</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://www.jmir.org/2014/9/e206/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.3304</pub-id>
        <pub-id pub-id-type="medline">25226790</pub-id>
        <pub-id pub-id-type="pii">v16i9e206</pub-id>
        <pub-id pub-id-type="pmcid">PMC4180352</pub-id></nlm-citation>
      </ref>
      <ref id="ref24">
        <label>24</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Palermo</surname>
            <given-names>TM</given-names>
          </name>
          <name name-style="western">
            <surname>Valenzuela</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Stork</surname>
            <given-names>PP</given-names>
          </name>
        </person-group>
        <article-title>A randomized trial of electronic versus paper pain diaries in children: impact on compliance, accuracy, and acceptability</article-title>
        <source>Pain</source>  
        <year>2004</year>  
        <month>02</month>  
        <volume>107</volume>  
        <issue>3</issue>  
        <fpage>213</fpage>  
        <lpage>9</lpage>  
        <pub-id pub-id-type="medline">14736583</pub-id>
        <pub-id pub-id-type="pii">S0304395903004135</pub-id></nlm-citation>
      </ref>
      <ref id="ref25">
        <label>25</label>
        <nlm-citation citation-type="book">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Grove</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Burns</surname>
            <given-names>N</given-names>
          </name>
          <name name-style="western">
            <surname>Gray</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <source>The Practice of Nursing Research. 7th Edition. Appraisal, Synthesis, and Generation of Evidence</source>  
        <year>2012</year>  
        <month>08</month>  
        <day>29</day>  
        <publisher-loc>Philadelphia, USA</publisher-loc>
        <publisher-name>Saunders</publisher-name></nlm-citation>
      </ref>
      <ref id="ref26">
        <label>26</label>
        <nlm-citation citation-type="book">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Holloway</surname>
            <given-names>I</given-names>
          </name>
          <name name-style="western">
            <surname>Wheeler</surname>
            <given-names>S</given-names>
          </name>
        </person-group>
        <source>Qualitative research in nursing and healthcare. 3rd Edition</source>  
        <year>2015</year>  
        <publisher-loc>Hoboken, NJ</publisher-loc>
        <publisher-name>Wiley-Blackwell</publisher-name></nlm-citation>
      </ref>
      <ref id="ref27">
        <label>27</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Elo</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Kyngäs</surname>
            <given-names>Helvi</given-names>
          </name>
        </person-group>
        <article-title>The qualitative content analysis process</article-title>
        <source>J Adv Nurs</source>  
        <year>2008</year>  
        <month>04</month>  
        <volume>62</volume>  
        <issue>1</issue>  
        <fpage>107</fpage>  
        <lpage>15</lpage>  
        <pub-id pub-id-type="doi">10.1111/j.1365-2648.2007.04569.x</pub-id>
        <pub-id pub-id-type="medline">18352969</pub-id>
        <pub-id pub-id-type="pii">JAN4569</pub-id></nlm-citation>
      </ref>
      <ref id="ref28">
        <label>28</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
        <collab>The National Advisory Board on Social Welfare and Health Care Ethics: Ministry of Social Affairs and Mental Health</collab> </person-group>
        <source>Ethical grounds for the social and health care field</source>  
        <year>2012</year>  
        <publisher-loc>Helsinki, Finland</publisher-loc>
        <publisher-name>Etene Publications</publisher-name>
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://julkaisut.valtioneuvosto.fi/handle/10024/69923">http://julkaisut.valtioneuvosto.fi/handle/10024/69923</ext-link>
          <ext-link ext-link-type="webcite" xlink:href="70sY6lXZP"/>
        </comment> </nlm-citation>
      </ref>
      <ref id="ref29">
        <label>29</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <collab>World Medical Association</collab>
        </person-group>
        <article-title>World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects</article-title>
        <source>JAMA</source>  
        <year>2013</year>  
        <month>11</month>  
        <day>27</day>  
        <volume>310</volume>  
        <issue>20</issue>  
        <fpage>2191</fpage>  
        <lpage>4</lpage>  
        <pub-id pub-id-type="doi">10.1001/jama.2013.281053</pub-id>
        <pub-id pub-id-type="medline">24141714</pub-id>
        <pub-id pub-id-type="pii">1760318</pub-id></nlm-citation>
      </ref>
      <ref id="ref30">
        <label>30</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Kauppi</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Kannisto</surname>
            <given-names>KA</given-names>
          </name>
          <name name-style="western">
            <surname>Hätönen</surname>
            <given-names>Heli</given-names>
          </name>
          <name name-style="western">
            <surname>Anttila</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Löyttyniemi</surname>
            <given-names>Eliisa</given-names>
          </name>
          <name name-style="western">
            <surname>Adams</surname>
            <given-names>CE</given-names>
          </name>
          <name name-style="western">
            <surname>Välimäki</surname>
            <given-names>Maritta</given-names>
          </name>
        </person-group>
        <article-title>Mobile phone text message reminders: Measuring preferences of people with antipsychotic medication</article-title>
        <source>Schizophr Res</source>  
        <year>2015</year>  
        <month>10</month>  
        <volume>168</volume>  
        <issue>1-2</issue>  
        <fpage>514</fpage>  
        <lpage>22</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.schres.2015.07.044</pub-id>
        <pub-id pub-id-type="medline">26293215</pub-id>
        <pub-id pub-id-type="pii">S0920-9964(15)00410-7</pub-id></nlm-citation>
      </ref>
      <ref id="ref31">
        <label>31</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Kannisto</surname>
            <given-names>KA</given-names>
          </name>
          <name name-style="western">
            <surname>Korhonen</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Adams</surname>
            <given-names>CE</given-names>
          </name>
          <name name-style="western">
            <surname>Koivunen</surname>
            <given-names>MH</given-names>
          </name>
          <name name-style="western">
            <surname>Vahlberg</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Välimäki</surname>
            <given-names>Maritta Anneli</given-names>
          </name>
        </person-group>
        <article-title>Factors Associated With Dropout During Recruitment and Follow-Up Periods of a mHealth-Based Randomized Controlled Trial for Mobile.Net to Encourage Treatment Adherence for People With Serious Mental Health Problems</article-title>
        <source>J Med Internet Res</source>  
        <year>2017</year>  
        <month>12</month>  
        <day>21</day>  
        <volume>19</volume>  
        <issue>2</issue>  
        <fpage>e46</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://www.jmir.org/2017/2/e46/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.6417</pub-id>
        <pub-id pub-id-type="medline">28223262</pub-id>
        <pub-id pub-id-type="pii">v19i2e46</pub-id>
        <pub-id pub-id-type="pmcid">PMC5340923</pub-id></nlm-citation>
      </ref>
      <ref id="ref32">
        <label>32</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Krogh</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Larsson</surname>
            <given-names>B</given-names>
          </name>
          <collab>Salvesen</collab>
          <name name-style="western">
            <surname>Linde</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>A comparison between prospective Internet-based and paper diary recordings of headache among adolescents in the general population</article-title>
        <source>Cephalalgia</source>  
        <year>2016</year>  
        <month>04</month>  
        <volume>36</volume>  
        <issue>4</issue>  
        <fpage>335</fpage>  
        <lpage>45</lpage>  
        <pub-id pub-id-type="doi">10.1177/0333102415591506</pub-id>
        <pub-id pub-id-type="medline">26092285</pub-id>
        <pub-id pub-id-type="pii">0333102415591506</pub-id></nlm-citation>
      </ref>
      <ref id="ref33">
        <label>33</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Lee</surname>
            <given-names>SW</given-names>
          </name>
          <name name-style="western">
            <surname>Kim</surname>
            <given-names>I</given-names>
          </name>
          <name name-style="western">
            <surname>Yoo</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Park</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Jeong</surname>
            <given-names>B</given-names>
          </name>
          <name name-style="western">
            <surname>Cha</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>Insights from an expressive writing intervention on Facebook to help alleviate depressive symptoms</article-title>
        <source>Computers in Human Behavior</source>  
        <year>2016</year>  
        <month>09</month>  
        <volume>62</volume>  
        <fpage>613</fpage>  
        <lpage>619</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.chb.2016.04.034</pub-id></nlm-citation>
      </ref>
      <ref id="ref34">
        <label>34</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Lumley</surname>
            <given-names>MA</given-names>
          </name>
          <name name-style="western">
            <surname>Provenzano</surname>
            <given-names>KM</given-names>
          </name>
        </person-group>
        <article-title>Stress management through written emotional disclosure improves academic performance among college students with physical symptoms</article-title>
        <source>Journal of Educational Psychology</source>  
        <year>2003</year>  
        <volume>95</volume>  
        <issue>3</issue>  
        <fpage>641</fpage>  
        <lpage>649</lpage>  
        <pub-id pub-id-type="doi">10.1037/0022-0663.95.3.641</pub-id></nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
