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<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="2.0">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v21i12e15870</article-id>
      <article-id pub-id-type="pmid">31815676</article-id>
      <article-id pub-id-type="doi">10.2196/15870</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Paper</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Original Paper</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Attitudes Toward Blockchain Technology in Managing Medical Information: Survey Study</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Eysenbach</surname>
            <given-names>Gunther</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Raghavendra</surname>
            <given-names>Meda</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Kuo</surname>
            <given-names>Tsung-Ting</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author">
          <name name-style="western">
            <surname>Hau</surname>
            <given-names>Yong Sauk</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-9817-4815</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Lee</surname>
            <given-names>Jae Min</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-6822-1051</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Park</surname>
            <given-names>Jaechan</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-4657-2114</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author" corresp="yes" equal-contrib="yes">
          <name name-style="western">
            <surname>Chang</surname>
            <given-names>Min Cheol</given-names>
          </name>
          <degrees>MD</degrees>
          <xref rid="aff3" ref-type="aff">3</xref>
          <address>
            <institution>Department of Physical Medicine and Rehabilitation</institution>
            <institution>College of Medicine</institution>
            <institution>Yeungnam University</institution>
            <addr-line>317-1, Daemyungdong, Namku</addr-line>
            <addr-line>Taegu, 705-717</addr-line>
            <country>Republic of Korea</country>
            <phone>82 1093621220</phone>
            <email>wheel633@gmail.com</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7629-7213</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Department of Business Administration, School of Business, Yeungnam University</institution>
        <addr-line>Gyeongsan-si</addr-line>
        <country>Republic of Korea</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Department of Pediatrics</institution>
        <institution>College of Medicine</institution>
        <institution>Yeungnam University</institution>
        <addr-line>Taegu</addr-line>
        <country>Republic of Korea</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>Department of Physical Medicine and Rehabilitation</institution>
        <institution>College of Medicine</institution>
        <institution>Yeungnam University</institution>
        <addr-line>Taegu</addr-line>
        <country>Republic of Korea</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Min Cheol Chang <email>wheel633@gmail.com</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <month>12</month>
        <year>2019</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>9</day>
        <month>12</month>
        <year>2019</year>
      </pub-date>
      <volume>21</volume>
      <issue>12</issue>
      <elocation-id>e15870</elocation-id>
      <history>
        <date date-type="received">
          <day>14</day>
          <month>8</month>
          <year>2019</year>
        </date>
        <date date-type="rev-request">
          <day>3</day>
          <month>9</month>
          <year>2019</year>
        </date>
        <date date-type="rev-recd">
          <day>27</day>
          <month>9</month>
          <year>2019</year>
        </date>
        <date date-type="accepted">
          <day>20</day>
          <month>10</month>
          <year>2019</year>
        </date>
      </history>
      <copyright-statement>©Yong Sauk Hau, Jae Min Lee, Jaechan Park, Min Cheol Chang. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 09.12.2019.</copyright-statement>
      <copyright-year>2019</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://www.jmir.org/2019/12/e15870" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>The recently developed blockchain technology uses a peer-to-peer network to distribute data to all participants for storage. This method enhances data safety, reliability, integrity, and transparency. To successfully introduce blockchain technology to medical data management, it is essential to obtain consent from medical doctors and patients.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>The aim of this study was to examine medical doctors’ and patients’ attitudes toward the use of blockchain technology and interpret the findings within the framework of expectancy theory.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>In this questionnaire survey, we examined medical doctors’ (n=90) and patients’ (n=90) attitudes toward the use of blockchain technology in the management and distribution of medical information. The questionnaire comprised 8 questions that assessed attitudes toward new means of managing and distributing medical information using blockchain technology. Responses were rated on a scale that ranged from 1 (very negative) to 7 (very positive).</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>Medical doctors (mean 3.7-5.0) reported significantly more negative attitudes than patients (mean 6.3-6.8). Furthermore, self-employed doctors reported more negative attitudes than employed doctors and university professors.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>To successfully introduce blockchain technology to medical data management, it is necessary to promote positive attitudes toward this technology among medical doctors, especially self-employed doctors.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>electronic health records</kwd>
        <kwd>attitude</kwd>
        <kwd>medical staff</kwd>
        <kwd>patient</kwd>
        <kwd>surveys and questionnaires</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>In addition to an increase in life expectancy and use of health care services, medical advances have also led to an exponential growth in the amount of patient medical information available [<xref ref-type="bibr" rid="ref1">1</xref>]. At present, different hospitals store and manage different fragments of a patient’s medical information. This method of managing medical information entails 4 disadvantages [<xref ref-type="bibr" rid="ref1">1</xref>]. First, it makes it difficult for medical doctors to fully identify patients’ medical information. Second, as doctors do not have access to patients’ complete medical records, they may subject patients to redundant medical examinations that they have previously undergone in other hospitals. Third, when an interhospital transfer occurs, a patient or his/her guardian will be required to print the medical information on paper, transfer or copy imaging scans onto a CD, and submit them to another hospital. This process is not only inconvenient to the patient or guardian, but the process also carries the risk of omission of certain aspects of patient medical information. Finally, there is a risk that the information that is stored in the hospital may be hacked and leaked.</p>
        <p>The recently developed blockchain technology differs from the conventional method of data storage in a central server or specific institution. Specifically, it uses a peer-to-peer network that distributes the data to all participants for storage; these users are responsible for hosting and managing the data [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>]. This technology enhances data safety, reliability, integrity, and transparency [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>]. Conventional centralized networks store data in a central server so that only a single central institution has access to the information. In contrast, blockchain-based distribution networks assign an account that contains distributable data to each user [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>]. This renders hacking virtually impossible because anyone who wishes to modify the stored data will have to simultaneously hack into a vast number of user accounts [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>]. Given this advantage, blockchain technology has been applied in diverse fields, such as finance, distribution, logistics, public services, and arts [<xref ref-type="bibr" rid="ref6">6</xref>].</p>
        <p>Recently, technology has gained a growing interest in the field of medicine [<xref ref-type="bibr" rid="ref7">7</xref>-<xref ref-type="bibr" rid="ref11">11</xref>]. Particularly, the use of blockchain technology in the transfer of medical data allows the patient rather than the hospital to own medical data. As a result, the patient rather than the hospital has control over medical data [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref7">7</xref>]. This enables patients to conveniently submit a complete set of medical data to any hospital upon transfer, and it helps physicians gain a better understanding of patients on the basis of the submitted data and plan suitable treatments [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref7">7</xref>]. In addition, it can reduce health care costs because patients are less likely to be subjected to redundant medical examinations when complete medical information is available. Moreover, it greatly reduces the risk of potential disclosure of patient medical information [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref7">7</xref>]. These advantages of blockchain technology are expected to have a positive influence on clinicians and patients.</p>
      </sec>
      <sec>
        <title>Objectives</title>
        <p>However, the initial stages of introduction of blockchain technology to medical practice may involve challenges. Particularly, the introduction of blockchain technology to medical data management necessitates the fulfillment of 2 criteria: (1) it must solve technical problems, and (2) health care service providers (ie, medical doctors) and consumers (ie, patients) must consent to its use. According to expectancy theory [<xref ref-type="bibr" rid="ref12">12</xref>], which is a widely used theory of human motivation in the field of psychology, medical doctors and patients are more likely to use blockchain technology when they hold positive attitudes toward it, and they are less likely to use it when they hold negative attitudes toward it. In this regard, medical doctors’ and patients’ attitudes are salient factors that must be examined in research studies on the application of blockchain technology to medical data management because a person’s attitude toward using a new information technology is indicative of their likelihood of using it [<xref ref-type="bibr" rid="ref13">13</xref>]. However, the extant research on the introduction of blockchain technology to the health care sector has not shed any light on medical doctors’ and patients’ attitudes. Therefore, this study attempted to examine medical doctors’ and patients’ attitudes toward the use of blockchain technology and interpret the findings within the framework of expectancy theory [<xref ref-type="bibr" rid="ref12">12</xref>].</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Survey</title>
        <p>The investigations were carried out following the rules of the Declaration of Helsinki of 1975. We conducted a questionnaire survey among practicing medical doctors who were between the ages of 30 and 49 years. Before the participants responded to the questionnaires, they viewed a video. The authors do not have any associations or relationships with the company that produced the video. In addition, a questionnaire survey was conducted among patients who were between the ages of 30 and 49 years. We think that the medical doctors under the age of 30 years are not experienced in the medical field enough to conduct this survey, and some doctors and patients over the age 49 years might find it difficult to understand blockchain technology. These participants were recruited from the lobby of a university hospital, and they provided consent before their participation in the survey.</p>
        <p>The questionnaire comprised items that assessed attitudes toward new means of managing and distributing medical information using blockchain technology [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>]. The questionnaire comprised the following items: (1) unlike traditional methods of medical data management, which bestow complete control over medical information to the hospital, blockchain technology allows a patient to choose the extent to which their medical information is stored, distributed, and managed; (2) blockchain technology delivers each aspect of a patient’s medical information to medical doctors; (3) as blockchain technology renders it impossible for one to hack medical information, it enhances the security of patient medical information; (4) blockchain technology prohibits anyone from revising a medical chart without patient consent once it has been created by a medical doctor; (5) blockchain technology allows patients to access information anywhere and at any time; (6) as blockchain technology allows hospitals to exchange medical information, patients do not have to print medical charts on paper, copy imaging scans onto a CD, and submit them to another hospital; (7) as blockchain technology reduces the likelihood of patients being subjected to redundant medical examinations, it lowers health care costs and reduces the time that patients spend at a hospital; and (8) blockchain technology makes it possible for one to use standardized medical big data to enhance the precision and personalization of medical treatments.</p>
        <p>The items that were used to measure attitudes toward blockchain technology were adapted from a validated measure that has been used in previous studies, such as those that have been conducted by Venkatesh et al [<xref ref-type="bibr" rid="ref13">13</xref>] and Min et al [<xref ref-type="bibr" rid="ref16">16</xref>]. Responses to each item were recorded on a scale that ranged from 1 (<italic>very negative</italic>) to 7 (<italic>very positive</italic>). Higher scores were indicative of more positive attitudes, whereas lower scores were indicative of more negative attitudes.</p>
        <p>The item that was used to gauge the levels of medical doctors’ and patients’ previous knowledge about blockchain technology was adapted from a validated measure in a similar previous study by Bettman and Park [<xref ref-type="bibr" rid="ref17">17</xref>]. The level of previous knowledge about blockchain technology was gauged on a scale ranging from 1 (<italic>do not know it at all</italic>) to 7 (<italic>know it very well</italic>).</p>
      </sec>
      <sec>
        <title>Statistical Analysis</title>
        <p>The collected data were analyzed using SPSS Version 24.0 (IBM Corporation). The data were analyzed in 2 steps. In the first step, the demographic characteristics and attitudes of medical doctors and patients were compared using the Mann-Whitney <italic>U</italic> and Chi-square tests. In the second step, Kruskal-Wallis and Mann-Whitney <italic>U</italic> tests were conducted to compare the demographic characteristics and attitudes of self-employed and employed doctors and university professors; the least significant difference test was used as a posthoc test. The level of statistical significance was specified as <italic>P</italic>&#60;.05.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Demographics</title>
        <p>A total of 90 medical doctors from 16 different departments and 90 patients participated in this survey. <xref ref-type="table" rid="table1">Table 1</xref> presents their demographic characteristics, and <xref ref-type="table" rid="table2">Table 2</xref> summarizes the distribution of medical doctors across the 16 different departments that they represented.</p>
        <p>The results of the first step of data analysis revealed no significant differences in the demographic characteristics of medical doctors and patients (<xref ref-type="table" rid="table1">Table 1</xref>).</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Significance of the difference in the demographic characteristics of medical doctors and patients.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="430"/>
            <col width="280"/>
            <col width="190"/>
            <col width="100"/>
            <thead>
              <tr valign="top">
                <td>Demographic characteristics</td>
                <td>Medical doctors (n=90)</td>
                <td>Patients (n=90)</td>
                <td><italic>P</italic> value</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Age (years), 30s:40s, n</td>
                <td>62:28</td>
                <td>60:30</td>
                <td>.75</td>
              </tr>
              <tr valign="top">
                <td>Gender, male:female, n</td>
                <td>62:28</td>
                <td>60:30</td>
                <td>.75</td>
              </tr>
              <tr valign="top">
                <td> Level of prior knowledge<sup>a</sup>, mean (SD)</td>
                <td>3.0 (1.4)</td>
                <td>3.0 (1.5)</td>
                <td>.69</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>Level of prior knowledge about blockchain technology was rated on a scale that ranged from 1 (Do not know it at all) to 7 (Know it very well). Higher scores are indicative of a higher level of prior knowledge about blockchain technology.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Distribution of medical doctors across the departments that they represented (N=90).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="670"/>
            <col width="330"/>
            <thead>
              <tr valign="top">
                <td>Department</td>
                <td>Frequency, n (%)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Rehabilitation and physical medicine</td>
                <td>27 (30)</td>
              </tr>
              <tr valign="top">
                <td>Pediatrics</td>
                <td>14 (16)</td>
              </tr>
              <tr valign="top">
                <td>Neurosurgery</td>
                <td>6 (7)</td>
              </tr>
              <tr valign="top">
                <td>Anesthesiology</td>
                <td>6 (7)</td>
              </tr>
              <tr valign="top">
                <td>Family medicine</td>
                <td>6 (7)</td>
              </tr>
              <tr valign="top">
                <td>General practice</td>
                <td>6 (7)</td>
              </tr>
              <tr valign="top">
                <td>Internal medicine</td>
                <td>5 (6)</td>
              </tr>
              <tr valign="top">
                <td>Orthopedics</td>
                <td>3 (3)</td>
              </tr>
              <tr valign="top">
                <td>Dermatology</td>
                <td>3 (3)</td>
              </tr>
              <tr valign="top">
                <td>Plastic surgery</td>
                <td>3 (3)</td>
              </tr>
              <tr valign="top">
                <td>Obstetrics and gynecology</td>
                <td>3 (3)</td>
              </tr>
              <tr valign="top">
                <td>Diagnostic medicine</td>
                <td>3 (3)</td>
              </tr>
              <tr valign="top">
                <td>Psychiatry</td>
                <td>2 (2)</td>
              </tr>
              <tr valign="top">
                <td>General surgery</td>
                <td>1 (1)</td>
              </tr>
              <tr valign="top">
                <td>Radiology</td>
                <td>1 (1)</td>
              </tr>
              <tr valign="top">
                <td>Radiation oncology</td>
                <td>1 (1)</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
      <sec>
        <title>Result of Survey</title>
        <p>The emergent means for all items that measured attitudes toward blockchain technology (ie, &#62;3.5) were indicative of positive attitudes among both medical doctors and patients (<xref ref-type="table" rid="table3">Table 3</xref>).</p>
        <table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Significance of the difference in attitudes toward the use of blockchain technology in the management of medical information between medical doctors and patients.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="664"/>
            <col width="137"/>
            <col width="121"/>
            <col width="78"/>
            <thead>
              <tr valign="top">
                <td>Blockchain technology application</td>
                <td>Medical doctors, mean (SD)</td>
                <td>Patients, mean (SD)</td>
                <td><italic>P</italic> value<sup>a</sup></td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>(1) Unlike traditional methods of medical data management, which bestow complete control over medical information to the hospital, blockchain technology allows a patient to choose the extent to which their medical information is stored, distributed, and managed.</td>
                <td>3.9 (1.9)</td>
                <td>6.4 (0.8)</td>
                <td>
                  <italic>&#60;.001</italic>
                </td>
              </tr>
              <tr valign="top">
                <td>(2) Blockchain technology delivers each aspect of a patient’s medical information to medical doctors.</td>
                <td>4.4 (1.9)</td>
                <td>6.3 (0.9)</td>
                <td>
                  <italic>&#60;.001</italic>
                </td>
              </tr>
              <tr valign="top">
                <td>(3) As blockchain technology renders it impossible for one to hack medical information, it enhances the security of patient medical information.</td>
                <td>4.4 (1.8)</td>
                <td>6.8 (0.5)</td>
                <td>
                  <italic>&#60;.001</italic>
                </td>
              </tr>
              <tr valign="top">
                <td>(4) Blockchain technology prohibits anyone from revising a medical chart without patient consent once it has been created by a medical doctor.</td>
                <td>3.7 (1.9)</td>
                <td>6.4 (1.0)</td>
                <td>
                  <italic>&#60;.001</italic>
                </td>
              </tr>
              <tr valign="top">
                <td>(5) Blockchain technology allows patients to access information anywhere and at any time.</td>
                <td>4.2 (1.9)</td>
                <td>6.7 (0.6)</td>
                <td>
                  <italic>&#60;.001</italic>
                </td>
              </tr>
              <tr valign="top">
                <td>(6) As blockchain technology allows hospitals to exchange medical information, patients do not have to print medical charts on paper, copy imaging scans onto a CD, and submit them to another hospital.</td>
                <td>5.0 (1.9)</td>
                <td>6.8 (0.5)</td>
                <td>
                  <italic>&#60;.001</italic>
                </td>
              </tr>
              <tr valign="top">
                <td> (7) As blockchain technology reduces the likelihood of patients being subjected to redundant medical examinations, it lowers health care costs and reduces the time that patients spend at a hospital.</td>
                <td>4.7 (2.0)</td>
                <td>6.8 (0.5)</td>
                <td>
                  <italic>&#60;.001</italic>
                </td>
              </tr>
              <tr valign="top">
                <td>(8) Blockchain technology makes it possible for one to use standardized medical big data to enhance the precision and personalization of medical treatments.</td>
                <td>4.7 (2.0)</td>
                <td>6.7 (0.8)</td>
                <td>
                  <italic>&#60;.001</italic>
                </td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table3fn1">
              <p><sup>a</sup>Values in italics are significant at the .05 level of significance.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <p>However, medical doctors reported significantly more negative attitudes than patients across all items (mean 3.7-5.0; <xref ref-type="table" rid="table3">Table 3</xref>). Medical doctors reported the most negative attitude (mean 3.7) for the following item (ie, item 4): “blockchain technology prohibits anyone from revising a medical chart without patient consent once it has been created by a medical doctor.” The second most negative attitude (mean 3.9) was reported for the following item (ie, item 1): “unlike traditional methods of medical data management, which bestow complete control over medical information to the hospital, blockchain technology allows a patient to choose the extent to which their medical information is stored, distributed, and managed.” Meanwhile, patients reported more positive attitudes than medical doctors across all items (mean 6.3-6.8; <xref ref-type="table" rid="table3">Table 3</xref>).</p>
        <p>The results of the second step of data analysis revealed no significant difference in the demographic characteristics of self-employed and employed doctors and university professors (<xref ref-type="table" rid="table4">Table 4</xref>).</p>
        <p>Self-employed doctors reported significantly more negative attitudes than employed doctors and university professors on the following two items (<xref ref-type="table" rid="table5">Table 5</xref>): “since blockchain technology allows hospitals to exchange medical information, patients do not have to print medical charts on paper, copy imaging scans onto a CD, and submit them to another hospital” (item 6) and “since blockchain technology reduces the likelihood of patients being subjected to redundant medical examinations, it lowers health care costs and reduces the time that patients spend at a hospital.” (item 7). There was no significant difference among the 3 groups on the other items (<xref ref-type="table" rid="table5">Table 5</xref>).</p>
        <table-wrap position="float" id="table4">
          <label>Table 4</label>
          <caption>
            <p>Significance of the difference in the demographic characteristics of self-employed and employed doctors and university professors.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="280"/>
            <col width="210"/>
            <col width="190"/>
            <col width="210"/>
            <col width="110"/>
            <thead>
              <tr valign="top">
                <td>Demographic characteristics</td>
                <td>Self-employed doctors (n=14)</td>
                <td>Employed doctors (n=54)</td>
                <td>University professors (n=22)</td>
                <td><italic>P</italic> value</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Age (years), 30s:40s, n</td>
                <td>7:7</td>
                <td>13:41</td>
                <td>14:8</td>
                <td>.15</td>
              </tr>
              <tr valign="top">
                <td>Gender, male:female, n</td>
                <td>12:2</td>
                <td>36:18</td>
                <td>14:8</td>
                <td>.32</td>
              </tr>
              <tr valign="top">
                <td>Level of prior knowledge<sup>a</sup>, mean (SD)</td>
                <td>3.1 (1.5)</td>
                <td>3.0 (1.5)</td>
                <td>2.8 (1.4)</td>
                <td>.74</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table4fn1">
              <p><sup>a</sup>Level of prior knowledge about blockchain technology was rated on a scale that ranged from 1 (<italic>Do not know it at all</italic>) to 7 (<italic>Know it very well</italic>). Higher scores are indicative of a higher level of prior knowledge about blockchain technology.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <table-wrap position="float" id="table5">
          <label>Table 5</label>
          <caption>
            <p>Significance of the difference in attitudes toward new methods of managing medical information using blockchain technology among self-employed doctors, employed doctors, and university professors.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="496"/>
            <col width="145"/>
            <col width="141"/>
            <col width="148"/>
            <col width="70"/>
            <thead>
              <tr valign="top">
                <td>Blockchain technology application</td>
                <td>Self-employed doctors, mean (SD)</td>
                <td>Employed doctors, mean (SD)</td>
                <td>University professors, mean (SD)</td>
                <td><italic>P</italic> value</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>(1) Unlike traditional methods of medical data management, which bestow complete control over medical information to the hospital, blockchain technology allows a patient to choose the extent to which their medical information is stored, distributed, and managed.</td>
                <td>3.0 (1.9)</td>
                <td>4.0 (1.9)</td>
                <td>4.4 (1.7)</td>
                <td>.09</td>
              </tr>
              <tr valign="top">
                <td>(2) Blockchain technology delivers each aspect of a patient’s medical information to medical doctors.</td>
                <td>3.5 (2.4)</td>
                <td>4.5 (1.9)</td>
                <td>4.8 (1.6)</td>
                <td>.10</td>
              </tr>
              <tr valign="top">
                <td>(3) As blockchain technology renders it impossible for one to hack medical information, it enhances the security of patient medical information.</td>
                <td>4.5 (2.0)</td>
                <td>4.4 (1.8)</td>
                <td>4.5 (1.8)</td>
                <td>&#62;.99</td>
              </tr>
              <tr valign="top">
                <td>(4) Blockchain technology prohibits anyone from revising a medical chart without patient consent once it has been created by a medical doctor.</td>
                <td>3.1 (1.9)</td>
                <td>3.9 (2.1)</td>
                <td>3.5 (1.5)</td>
                <td>.42</td>
              </tr>
              <tr valign="top">
                <td>(5) Blockchain technology allows patients to access information anywhere and at any time.</td>
                <td>3.3 (2.1)</td>
                <td>4.3(1.9)</td>
                <td>4.7 (1.6)</td>
                <td>.07</td>
              </tr>
              <tr valign="top">
                <td>(6) As blockchain technology allows hospitals to exchange medical information, patients do not have to print medical charts on paper, copy imaging scans onto a CD, and submit them to another hospital.</td>
                <td>3.5 (2.4)</td>
                <td>5.2 (1.8)</td>
                <td>5.4 (1.3)</td>
                <td>
                  <italic>.02<sup>a,b</sup></italic>
                </td>
              </tr>
              <tr valign="top">
                <td>(7) As blockchain technology reduces the likelihood of patients being subjected to redundant medical examinations, it lowers health care costs and reduces the time that patients spend at a hospital.</td>
                <td>2.9 (2.4)</td>
                <td>5.0 (1.9)</td>
                <td>5.1 (1.7)</td>
                <td>
                  <italic>.02<sup>a,b</sup></italic>
                </td>
              </tr>
              <tr valign="top">
                <td>(8) Blockchain technology makes it possible for one to use standardized medical big data to enhance the precision and personalization of medical treatments.</td>
                <td>3.8 (2.4)</td>
                <td>4.9 (2.0)</td>
                <td>5.0 (1.9)</td>
                <td>.14</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table5fn1">
              <p><sup>a</sup>Mean item score for self-employed doctors &#60; mean item score for employed doctors and university professors.</p>
            </fn>
            <fn id="table5fn2">
              <p><sup>b</sup>Values in italics are significant at the .05 level of significance.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>This study examined medical doctors’ and patients’ attitudes toward new methods of managing and distributing medical information using blockchain technology. The major findings of this study can be summarized into 3 points. First, medical doctors reported significantly more negative attitudes than patients across all items that measured attitudes toward the application of blockchain technology to the management and distribution of medical information (<xref ref-type="table" rid="table3">Table 3</xref>). Second, self-employed doctors reported significantly more negative attitudes than employed doctors and university professors on the sixth and seventh items, which pertain to 2 advantages of blockchain technology, namely, convenient exchange of medical information among hospitals and lower number of redundant medical examinations (<xref ref-type="table" rid="table5">Table 5</xref>). Third, patients obtained means that ranged from 6 to 7 across all the items; this indicates that they held very positive attitudes toward the application of blockchain technology to medical data management (<xref ref-type="table" rid="table3">Table 3</xref>).</p>
        <p>The 3 major findings of this study can be interpreted within the framework of the expectancy theory of psychological motivation [<xref ref-type="bibr" rid="ref12">12</xref>], which suggests that people are motivated to pursue positive outcomes and avoid negative outcomes [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref18">18</xref>]. In this regard, the first finding can be interpreted to mean that medical doctors have more negative attitudes about blockchain technology than patients as they expect its use to lead to negative outcomes. For example, medical doctors’ attitudes were most negative for the fourth item, which delineates how blockchain technology makes it difficult for one to revise medical charts (<xref ref-type="table" rid="table3">Table 3</xref>). This feature of blockchain technology may be disadvantageous to medical doctors, when there is a medical dispute between them and a patient or guardian. Similarly, the second most negative attitudes were reported for the first item, which articulates the fact that blockchain technology allows patients to have complete control over their medical data (<xref ref-type="table" rid="table3">Table 3</xref>). This may have caused medical doctors to be concerned about potential misuse of patient medical information. The second major finding of this study has practical implications as it suggests that the use of blockchain technology may lead to negative outcomes among self-employed doctors. According to expectancy theory [<xref ref-type="bibr" rid="ref12">12</xref>], there is a perceived association between a person’s actions and their consequent rewards [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref18">18</xref>]. Rewards may be of various types (eg, money and praise from other people) [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref18">18</xref>]. Self-employed doctors reported significantly more negative attitudes than employed doctors and university professors on the sixth and seventh items (<xref ref-type="table" rid="table5">Table 5</xref>). These items pertain to 2 advantages of blockchain technology: (1) it facilitates convenient transfer of medical information among hospitals, and (2) it lowers health care costs and reduces the time that patients spend at a hospital by minimizing the need for redundant medical examinations. As the profits that are earned from medical examinations contribute to self-employed doctors’ incomes, they may worry that the use of blockchain technology will lower their income. More specifically, patients may decline undergoing a medical examination that has been recommended by a smaller clinic if they have already undergone similar examinations in a larger hospital, even when such examinations are required to make an accurate medical diagnosis.</p>
        <p>The third finding of this study suggests that patients hold very favorable attitudes toward the use of blockchain technology. This may be because of the fact that the application of blockchain technology to medical data management will yield outcomes that are beneficial rather than harmful to patients. Expectancy theory suggests that people cognitively analyze the gains and losses of behaviors in which they intend to engage [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref18">18</xref>]. In this regard, blockchain technology may offer patients several gains and lead to only a few losses. For instance, it grants patients direct control over their medical information and enhances the transparency and stability of their medical records [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>]. Moreover, blockchain technology can decrease health care costs by diminishing the need for redundant medical examinations and making it easier to transfer patient medical information to another hospital [<xref ref-type="bibr" rid="ref1">1</xref>]. In addition, it can contribute to medical research by granting researchers access to patients’ personal medical data [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref4">4</xref>].</p>
        <p>The 3 major findings of this study, which are consistent with the premises of expectancy theory [<xref ref-type="bibr" rid="ref12">12</xref>], suggest that to successfully introduce blockchain technology to medical data management, it is necessary to promote positive attitudes toward this technology among medical doctors. This can be achieved by alleviating their concerns about the adverse outcomes of the introduction of blockchain technology to medical data management and raising awareness about its potential advantages to medical doctors. In addition, the findings suggest that it is especially necessary to alleviate self-employed doctors’ concerns about potential problems that may result from introducing blockchain technology to medical data management.</p>
        <p>At present, many companies worldwide are researching the means by which blockchain technology can be introduced to the health care sector [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref6">6</xref>]. Some pilot projects have been conducted in the domains of management and distribution of medical data. Although various studies have actively examined the new means by which blockchain technology can be applied to medical data management in the health care sector [<xref ref-type="bibr" rid="ref2">2</xref>-<xref ref-type="bibr" rid="ref7">7</xref>], none of the past studies have examined the attitudes of direct users of blockchain technology in health care sectors, namely, medical doctors and patients.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>In this study, we ascertained the extent to which the attitudes of medical doctors and patients are favorable toward the use of blockchain technology in the management and distribution of medical information. We found that medical doctors reported more negative attitudes than patients. Therefore, to introduce blockchain technology to medical data management, it is necessary to alleviate the concerns that medical doctors (especially self-employed doctors) have about the use of blockchain technology. Our study has some limitations. First, we did not examine the specific factors that lead to negative and positive attitudes toward the use of blockchain technology in medical data management. Second, diverse age groups were not represented in the study sample. Third, the number of doctors working in a specific department (physical medicine and rehabilitation) is disproportionately high. Fourth, the number of included subjects was relatively small. Fourth, a qualitative analysis method, such as a qualitative survey, can be effectively used to clearly show medical doctors’ and patients’ attitudes toward blockchain technology. However, we analyzed them by using only the quantitative analysis method using a questionnaire-based survey. Future studies that address these limitations will be able to enrich the present findings.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group/>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">NRF</term>
          <def>
            <p>National Research Foundation</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>The 2017 Yeungnam University Research Grant supported this work. The National Research Foundation of Korea (NRF) Grant (NRF-2019R1F1A1061348) supported this work.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chang</surname>
              <given-names>MC</given-names>
            </name>
            <name name-style="western">
              <surname>Hau</surname>
              <given-names>YS</given-names>
            </name>
            <name name-style="western">
              <surname>Park</surname>
              <given-names>JC</given-names>
            </name>
            <name name-style="western">
              <surname>Lee</surname>
              <given-names>JM</given-names>
            </name>
          </person-group>
          <article-title>The application of blockchain technology in stroke rehabilitation</article-title>
          <source>Am J Phys Med Rehabil</source>
          <year>2019</year>
          <month>07</month>
          <volume>98</volume>
          <issue>7</issue>
          <fpage>e74</fpage>
          <pub-id pub-id-type="doi">10.1097/PHM.0000000000001083</pub-id>
          <pub-id pub-id-type="medline">30516553</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Jo</surname>
              <given-names>BW</given-names>
            </name>
            <name name-style="western">
              <surname>Khan</surname>
              <given-names>RM</given-names>
            </name>
            <name name-style="western">
              <surname>Lee</surname>
              <given-names>Y</given-names>
            </name>
          </person-group>
          <article-title>Hybrid blockchain and internet-of-things network for underground structure health monitoring</article-title>
          <source>Sensors (Basel)</source>
          <year>2018</year>
          <month>12</month>
          <day>4</day>
          <volume>18</volume>
          <issue>12</issue>
          <fpage>pii: E4268</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://www.mdpi.com/resolver?pii=s18124268"/>
          </comment>
          <pub-id pub-id-type="doi">10.3390/s18124268</pub-id>
          <pub-id pub-id-type="medline">30518124</pub-id>
          <pub-id pub-id-type="pii">s18124268</pub-id>
          <pub-id pub-id-type="pmcid">PMC6308517</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Park</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Youn</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Rhee</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Shin</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Smart contract-based review system for an IoT data marketplace</article-title>
          <source>Sensors (Basel)</source>
          <year>2018</year>
          <month>10</month>
          <day>22</day>
          <volume>18</volume>
          <issue>10</issue>
          <fpage>pii: E3577</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://www.mdpi.com/resolver?pii=s18103577"/>
          </comment>
          <pub-id pub-id-type="doi">10.3390/s18103577</pub-id>
          <pub-id pub-id-type="medline">30360413</pub-id>
          <pub-id pub-id-type="pii">s18103577</pub-id>
          <pub-id pub-id-type="pmcid">PMC6211088</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Mackey</surname>
              <given-names>TK</given-names>
            </name>
            <name name-style="western">
              <surname>Kuo</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Gummadi</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Clauson</surname>
              <given-names>KA</given-names>
            </name>
            <name name-style="western">
              <surname>Church</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Grishin</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Obbad</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Barkovich</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Palombini</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>'Fit-for-purpose?' - challenges and opportunities for applications of blockchain technology in the future of healthcare</article-title>
          <source>BMC Med</source>
          <year>2019</year>
          <month>03</month>
          <day>27</day>
          <volume>17</volume>
          <issue>1</issue>
          <fpage>68</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-019-1296-7"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/s12916-019-1296-7</pub-id>
          <pub-id pub-id-type="medline">30914045</pub-id>
          <pub-id pub-id-type="pii">10.1186/s12916-019-1296-7</pub-id>
          <pub-id pub-id-type="pmcid">PMC6436239</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ren</surname>
              <given-names>YJ</given-names>
            </name>
            <name name-style="western">
              <surname>Leng</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Cheng</surname>
              <given-names>YP</given-names>
            </name>
            <name name-style="western">
              <surname>Wang</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>Secure data storage based on blockchain and coding in edge computing</article-title>
          <source>Math Biosci Eng</source>
          <year>2019</year>
          <month>03</month>
          <day>7</day>
          <volume>16</volume>
          <issue>4</issue>
          <fpage>1874</fpage>
          <lpage>92</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://www.aimspress.com/article/10.3934/mbe.2019091"/>
          </comment>
          <pub-id pub-id-type="doi">10.3934/mbe.2019091</pub-id>
          <pub-id pub-id-type="medline">31137190</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Yli-Huumo</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Ko</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Choi</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Park</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Smolander</surname>
              <given-names>K</given-names>
            </name>
          </person-group>
          <article-title>Where is current research on blockchain technology?-a systematic review</article-title>
          <source>PLoS One</source>
          <year>2016</year>
          <volume>11</volume>
          <issue>10</issue>
          <fpage>e0163477</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://dx.plos.org/10.1371/journal.pone.0163477"/>
          </comment>
          <pub-id pub-id-type="doi">10.1371/journal.pone.0163477</pub-id>
          <pub-id pub-id-type="medline">27695049</pub-id>
          <pub-id pub-id-type="pii">PONE-D-16-17351</pub-id>
          <pub-id pub-id-type="pmcid">PMC5047482</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Balis</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Tagopoulos</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>Dimola</surname>
              <given-names>K</given-names>
            </name>
          </person-group>
          <article-title>Moving towards a blockchain-based healthcare information system</article-title>
          <source>Stud Health Technol Inform</source>
          <year>2019</year>
          <month>07</month>
          <day>4</day>
          <volume>262</volume>
          <fpage>168</fpage>
          <lpage>71</lpage>
          <pub-id pub-id-type="doi">10.3233/SHTI190044</pub-id>
          <pub-id pub-id-type="medline">31349293</pub-id>
          <pub-id pub-id-type="pii">SHTI190044</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Bernardi</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Lima</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Pellison</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Marques</surname>
              <given-names>PM</given-names>
            </name>
            <name name-style="western">
              <surname>Rijo</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Galliez</surname>
              <given-names>RM</given-names>
            </name>
            <name name-style="western">
              <surname>Kritski</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Alves</surname>
              <given-names>D</given-names>
            </name>
          </person-group>
          <article-title>Blockchain based network for tuberculosis: a data sharing initiative in Brazil</article-title>
          <source>Stud Health Technol Inform</source>
          <year>2019</year>
          <month>07</month>
          <day>4</day>
          <volume>262</volume>
          <fpage>264</fpage>
          <lpage>7</lpage>
          <pub-id pub-id-type="doi">10.3233/SHTI190069</pub-id>
          <pub-id pub-id-type="medline">31349318</pub-id>
          <pub-id pub-id-type="pii">SHTI190069</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Dimitrov</surname>
              <given-names>DV</given-names>
            </name>
          </person-group>
          <article-title>Blockchain applications for healthcare data management</article-title>
          <source>Healthc Inform Res</source>
          <year>2019</year>
          <month>01</month>
          <volume>25</volume>
          <issue>1</issue>
          <fpage>51</fpage>
          <lpage>6</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.e-hir.org/DOIx.php?id=10.4258/hir.2019.25.1.51"/>
          </comment>
          <pub-id pub-id-type="doi">10.4258/hir.2019.25.1.51</pub-id>
          <pub-id pub-id-type="medline">30788182</pub-id>
          <pub-id pub-id-type="pmcid">PMC6372466</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Drosatos</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Kaldoudi</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>Blockchain applications in the biomedical domain: a scoping review</article-title>
          <source>Comput Struct Biotechnol J</source>
          <year>2019</year>
          <volume>17</volume>
          <fpage>229</fpage>
          <lpage>40</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://linkinghub.elsevier.com/retrieve/pii/S2001-0370(18)30285-X"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.csbj.2019.01.010</pub-id>
          <pub-id pub-id-type="medline">30847041</pub-id>
          <pub-id pub-id-type="pii">S2001-0370(18)30285-X</pub-id>
          <pub-id pub-id-type="pmcid">PMC6389656</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Shuaib</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Saleous</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Shuaib</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Zaki</surname>
              <given-names>N</given-names>
            </name>
          </person-group>
          <article-title>Blockchains for secure digitized medicine</article-title>
          <source>J Pers Med</source>
          <year>2019</year>
          <month>07</month>
          <day>13</day>
          <volume>9</volume>
          <issue>3</issue>
          <fpage>pii: E35</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://www.mdpi.com/resolver?pii=jpm9030035"/>
          </comment>
          <pub-id pub-id-type="doi">10.3390/jpm9030035</pub-id>
          <pub-id pub-id-type="medline">31337080</pub-id>
          <pub-id pub-id-type="pii">jpm9030035</pub-id>
          <pub-id pub-id-type="pmcid">PMC6789651</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Vroom</surname>
              <given-names>VH</given-names>
            </name>
          </person-group>
          <source>Work and Motivation</source>
          <year>1964</year>
          <publisher-loc>New York</publisher-loc>
          <publisher-name>John Wiley</publisher-name>
        </nlm-citation>
      </ref>
      <ref id="ref13">
        <label>13</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Venkatesh</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Morris</surname>
              <given-names>MG</given-names>
            </name>
            <name name-style="western">
              <surname>Davis</surname>
              <given-names>GB</given-names>
            </name>
            <name name-style="western">
              <surname>Davis</surname>
              <given-names>FD</given-names>
            </name>
          </person-group>
          <article-title>User acceptance of information technology: toward a unified view</article-title>
          <source>Manag Inf Syst Q</source>
          <year>2003</year>
          <volume>27</volume>
          <issue>3</issue>
          <fpage>425</fpage>
          <lpage>80</lpage>
          <pub-id pub-id-type="doi">10.2307/30036540</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref14">
        <label>14</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chen</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Ding</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Xu</surname>
              <given-names>Z</given-names>
            </name>
            <name name-style="western">
              <surname>Zheng</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Yang</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Blockchain-based medical records secure storage and medical service framework</article-title>
          <source>J Med Syst</source>
          <year>2018</year>
          <month>11</month>
          <day>22</day>
          <volume>43</volume>
          <issue>1</issue>
          <fpage>5</fpage>
          <pub-id pub-id-type="doi">10.1007/s10916-018-1121-4</pub-id>
          <pub-id pub-id-type="medline">30467604</pub-id>
          <pub-id pub-id-type="pii">10.1007/s10916-018-1121-4</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref15">
        <label>15</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Gordon</surname>
              <given-names>WJ</given-names>
            </name>
            <name name-style="western">
              <surname>Catalini</surname>
              <given-names>C</given-names>
            </name>
          </person-group>
          <article-title>Blockchain technology for healthcare: facilitating the transition to patient-driven interoperability</article-title>
          <source>Comput Struct Biotechnol J</source>
          <year>2018</year>
          <volume>16</volume>
          <fpage>224</fpage>
          <lpage>30</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://linkinghub.elsevier.com/retrieve/pii/S2001-0370(18)30028-X"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.csbj.2018.06.003</pub-id>
          <pub-id pub-id-type="medline">30069284</pub-id>
          <pub-id pub-id-type="pii">S2001-0370(18)30028-X</pub-id>
          <pub-id pub-id-type="pmcid">PMC6068317</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref16">
        <label>16</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Min</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>Is power powerful? Power, confidence, and goal pursuit</article-title>
          <source>Int J Res Mark</source>
          <year>2013</year>
          <volume>30</volume>
          <issue>3</issue>
          <fpage>265</fpage>
          <lpage>75</lpage>
          <pub-id pub-id-type="doi">10.1016/j.ijresmar.2012.12.001</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref17">
        <label>17</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Bettman</surname>
              <given-names>JR</given-names>
            </name>
            <name name-style="western">
              <surname>Park</surname>
              <given-names>CW</given-names>
            </name>
          </person-group>
          <article-title>Effects of prior knowledge and experience and phase of the choice process on consumer decision processes: a protocol analysis</article-title>
          <source>J Consum Res</source>
          <year>1980</year>
          <volume>7</volume>
          <issue>3</issue>
          <fpage>234</fpage>
          <lpage>48</lpage>
          <pub-id pub-id-type="doi">10.1086/208812</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref18">
        <label>18</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Champoux</surname>
              <given-names>JE</given-names>
            </name>
          </person-group>
          <source>Organizational Behavior: Integrating Individuals, Groups, and Process</source>
          <year>1996</year>
          <publisher-loc>West Third Street, St. Paul</publisher-loc>
          <publisher-name>West Publishing Company</publisher-name>
        </nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
