<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "http://dtd.nlm.nih.gov/publishing/2.0/journalpublishing.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="2.0">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
    <article-id pub-id-type="publisher-id">v20i11e11032</article-id>
    <article-id pub-id-type="pmid">30455169</article-id>
    <article-id pub-id-type="doi">10.2196/11032</article-id>
    <article-categories>
      <subj-group subj-group-type="heading">
        <subject>Original Paper</subject>
      </subj-group>
      <subj-group subj-group-type="article-type">
        <subject>Original Paper</subject>
      </subj-group>
    </article-categories>
    <title-group>
      <article-title>New Integrated Model Approach to Understand the Factors That Drive Electronic Health Record Portal Adoption: Cross-Sectional National Survey</article-title>
    </title-group>
    <contrib-group>
      <contrib contrib-type="editor">
        <name>
          <surname>Eysenbach</surname>
          <given-names>Gunther</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Dias</surname>
          <given-names>Sara</given-names>
        </name>
      </contrib>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Dehghan</surname>
          <given-names>Hamid</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="author" id="contrib1" corresp="yes" equal-contrib="yes">
      <name name-style="western">
        <surname>Tavares</surname>
        <given-names>Jorge</given-names>
      </name>
      <degrees>MSc, PhD</degrees>
      <xref rid="aff1" ref-type="aff">1</xref>
      <address>
        <institution>NOVA Information Management School</institution>
        <institution>Universidade NOVA de Lisboa</institution>
        <addr-line>Campus de Campolide</addr-line>
        <addr-line>Lisboa, 1070 312</addr-line>
        <country>Portugal</country>
        <phone>351 213 828 610</phone>
        <email>d2012072@novaims.unl.pt</email>
      </address>  
      <ext-link ext-link-type="orcid">http://orcid.org/0000-0001-5551-8243</ext-link></contrib>
      <contrib contrib-type="author" id="contrib2">
        <name name-style="western">
          <surname>Oliveira</surname>
          <given-names>Tiago</given-names>
        </name>
        <degrees>PhD</degrees>
        <xref rid="aff1" ref-type="aff">1</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0001-6523-0809</ext-link>
      </contrib>
    </contrib-group>
    <aff id="aff1">
    <label>1</label>
    <institution>NOVA Information Management School</institution>
    <institution>Universidade NOVA de Lisboa</institution>  
    <addr-line>Lisboa</addr-line>
    <country>Portugal</country></aff>
    <author-notes>
      <corresp>Corresponding Author: Jorge Tavares 
      <email>d2012072@novaims.unl.pt</email></corresp>
    </author-notes>
    <pub-date pub-type="collection">
      <month>11</month>
      <year>2018</year>
    </pub-date>
    <pub-date pub-type="epub">
      <day>19</day>
      <month>11</month>
      <year>2018</year>
    </pub-date>
    <volume>20</volume>
    <issue>11</issue>
    <elocation-id>e11032</elocation-id>
    <!--history from ojs - api-xml-->
    <history>
      <date date-type="received">
        <day>13</day>
        <month>5</month>
        <year>2018</year>
      </date>
      <date date-type="rev-request">
        <day>4</day>
        <month>7</month>
        <year>2018</year>
      </date>
      <date date-type="rev-recd">
        <day>17</day>
        <month>7</month>
        <year>2018</year>
      </date>
      <date date-type="accepted">
        <day>17</day>
        <month>7</month>
        <year>2018</year>
      </date>
    </history>
    <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
    <copyright-statement>©Jorge Tavares, Tiago Oliveira. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 19.11.2018.</copyright-statement>
    <copyright-year>2018</copyright-year>
    <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
      <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.</p>
    </license>  
    <self-uri xlink:href="https://www.jmir.org/2018/11/e11032/" xlink:type="simple"/>
    <abstract>
      <sec sec-type="background">
        <title>Background</title>
        <p>The future of health care delivery is becoming more patient-focused, and electronic health record (EHR) portals are gaining more attention from worldwide governments that consider this technology as a valuable asset for the future sustainability of the national health care systems. Overall, this makes the adoption of EHR portals an important field to study.</p>
      </sec>
      <sec sec-type="objective">
        <title>Objective</title>
        <p>The aim of this study is to understand the factors that drive individuals to adopt EHR portals.</p>
      </sec>
      <sec sec-type="methods">
        <title>Methods</title>
        <p>We applied a new adoption model that combines 3 different theories, namely, extended unified theory of acceptance and use of technology, health belief model, and the diffusion of innovation; all the 3 theories provided relevant contributions for the understanding of EHR portals. To test the research model, we used the partial least squares causal modeling approach. We executed a national survey based on randomly generated mobile phone numbers. We collected 139 questionnaires.</p>
      </sec>
      <sec sec-type="results">
        <title>Results</title>
        <p>Performance expectancy (beta=.203; <italic>t</italic>=2.699), compatibility (beta=.530; <italic>t</italic>=6.189), and habit (beta=.251; <italic>t</italic>=2.660) have a statistically significant impact on behavior intention (<italic>R</italic><sup>2</sup>=76.0%). Habit (beta=.378; <italic>t</italic>=3.821), self-perception (beta=.233; <italic>t</italic>=2.971), and behavior intention (beta=.263; <italic>t</italic>=2.379) have a statistically significant impact on use behavior (<italic>R</italic><sup>2</sup>=61.8%). In addition, behavior intention (beta=.747; <italic>t</italic>=10.737) has a statistically significant impact on intention to recommend (<italic>R</italic><sup>2</sup>=69.0%), results demonstrability (beta=.403; <italic>t</italic>=2.888) and compatibility (beta=.337; <italic>t</italic>=2.243) have a statistically significant impact on effort expectancy (<italic>R</italic><sup>2</sup>=48.3%), and compatibility (beta=.594; <italic>t</italic>=6.141) has a statistically significant impact on performance expectancy (<italic>R</italic><sup>2</sup>=42.7%).</p>
      </sec>
      <sec sec-type="conclusions">
        <title>Conclusions</title>
        <p>Our research model yields very good results, with relevant <italic>R</italic><sup>2</sup> in the most important dependent variables that help explain the adoption of EHR portals, behavior intention, and use behavior.</p>
      </sec>
    </abstract>
    <kwd-group>
      <kwd>electronic health records</kwd>
      <kwd>adoption</kwd>
      <kwd>eHealth</kwd>
      <kwd>patients</kwd>
      <kwd>patient portals</kwd>
    </kwd-group></article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Overview</title>
        <p>The electronic health record (EHR) portal or an EHR patient portal is a technology that combines an EHR system and a patient portal where patients can communicate with their health care providers (eg, send messages, schedule medical appointments, and request prescription refills online) and access their EHR and medical exams results [<xref ref-type="bibr" rid="ref1">1</xref>-<xref ref-type="bibr" rid="ref3">3</xref>]. EHR is a repository of patient data in a digital form, stored and exchanged securely. EHRs may include a range of data such as medical history, medication and allergies, immunization status, laboratory test results, radiology images, vital signs, personal statistics like age and weight, and billing information [<xref ref-type="bibr" rid="ref4">4</xref>]. EHR portals have received great attention at the governmental level worldwide [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref5">5</xref>]. In the United States, the support given to EHRs, via a meaningful use program, led the federal government to commit unparalleled resources to support the adoption of EHRs through incentive payments that can reach up to US $27 billion over 10 years [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>]. EHR portals are a relevant topic not only in the United States but also in Europe through several projects such as the European Patients Smart Open Services (EpSOS) initiative promoted by the European Union Commission [<xref ref-type="bibr" rid="ref3">3</xref>]. EpSOS focuses on developing a practical information and communication technology infrastructure that will enable secure access to patient information, including EHR among different European countries [<xref ref-type="bibr" rid="ref3">3</xref>].</p>
        <p>Understanding the adoption and use of EHR portals by patients is a very relevant topic with clear benefits for the society and future sustainability of the different health care systems in the world [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref7">7</xref>]. The warning signs are that the number of patients with chronic diseases is projected to grow by 45% between 2007 and 2025, and the health care providers’ workforce will be 10% smaller [<xref ref-type="bibr" rid="ref8">8</xref>]. Combining these 2 trends, there will be less health care professionals available in the future to provide support to the patients. EHR portals may help patients carry out self-management activities, making the use of the health care system more effective and sustainable, not only from the patient care standpoint but also from the financial perspective due to the increasing cost of the health care budget in different countries [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref8">8</xref>-<xref ref-type="bibr" rid="ref10">10</xref>]. Regarding EHR portal users’ sociodemographic characteristics, there is a consistent trend to be younger and more educated than the population average [<xref ref-type="bibr" rid="ref11">11</xref>-<xref ref-type="bibr" rid="ref13">13</xref>].</p>
        <p>Most of the EHR portals’ usage in the developing countries ranges between 5% and 10% of the total annual target population that they aim to reach [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. Most of the EHR portals are implemented at an organizational or health care unit level, but there are some examples of EHR portals that have been implemented at the national level [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. Probably the most successful nationwide implementation of an EHR portal is the Sundhed portal in Denmark with 1.1 million unique registered users, approximately 20% coverage of the Danish population [<xref ref-type="bibr" rid="ref14">14</xref>]. In Portugal, both public and private health care institutions have EHR portals [<xref ref-type="bibr" rid="ref3">3</xref>]. The most relevant public EHR portal is the National Health Service (NHS) portal that in its first implementation was not very successful, but in its new release, which was launched recently, provides a higher level of security (2-factor authentication) and broader access to the patients to their clinical information across NHS [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref7">7</xref>]. Recently in Portugal, we also have good examples of investment by private health care groups, like the EHR portal MyCuf [<xref ref-type="bibr" rid="ref7">7</xref>]. What we also perceive in the private health care institutions such as MyCuf is the exclusive delivery of the medical examination results and other documentation online, increasing the use of this online platform and making it compulsory, something that is not yet a policy in the NHS [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref7">7</xref>]. Due to the fact that some of the private health care providers perceived an efficiency advantage, they have invested in developing more sophisticated portals than the public hospitals, but the new version of the NHS portal has now also started aggregating all the patient information from the different public health care institutions, making it available to the patient at one place [<xref ref-type="bibr" rid="ref7">7</xref>]. There are differences between the different types of EHR portals in the same country and among different countries, but the most common and frequently used features identified in the literature, which generally apply to an EHR portal, are as follows: management of health information and communication with health providers, medical appointments schedule, check their own EHR, and request for medical prescription renewals [<xref ref-type="bibr" rid="ref2">2</xref>-<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref15">15</xref>-<xref ref-type="bibr" rid="ref17">17</xref>]. Taking into account the relevance of all the current initiatives that are ongoing in Portugal regarding EHR portals, a nationwide survey using a sample of randomly generated mobile numbers was applied in our study.</p>
        <p>The goals of this study are to estimate the percentage of EHR portal users among the Portuguese population and understand the factors that drive health care consumers to adopt and use EHR portals. We apply 3 different theories to build our research model: the extended unified theory of acceptance and use of technology (UTAUT2), the health belief model (HBM) theory, and the diffusion of innovation (DOI) theory. In the Research Model section, a more detailed rationale explaining why we combined these 3 theories is provided.</p>
      </sec>
      <sec>
        <title>Theoretical Background</title>
        <p>The goal of our study is to focus on the adoption of the EHR portals from the standpoint of the health care consumer. According to the literature, assessing the adoption of eHealth tools by health care consumers still demands more effort due to the persisting low number of studies published to date and in view of the importance of the topic [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>]. The most frequently used adoption models when studying eHealth adoption by health care professionals are the unified theory of acceptance and use of technology [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>] and the technology acceptance model (TAM) [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref21">21</xref>]. When evaluating the studies published in the field of consumer health information technology adoption, most of the research studies use TAM or extensions of TAM [<xref ref-type="bibr" rid="ref22">22</xref>-<xref ref-type="bibr" rid="ref25">25</xref>]. Although the studies that used extended TAM used other models and theories with TAM to adapt it to the consumer health technology context (see <xref ref-type="table" rid="table1">Table 1</xref>), TAM was not envisaged with consumer focus in mind. Rather, we need a model developed for the consumer use setting, and UTAUT2 was developed precisely with this purpose, achieving good results [<xref ref-type="bibr" rid="ref26">26</xref>]. A recent study using a UTAUT2 extension demonstrated its usefulness in assessing the critical determinants for the adoption of EHR portals in which the construct habit, which is a consumer-specific construct, was the one with the greatest impact on the adoption of EHR portals [<xref ref-type="bibr" rid="ref2">2</xref>]. This fact shows the importance of using research models that are consumer specific.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>eHealth patient-focused adoption models.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="200"/>
            <col width="210"/>
            <col width="500"/>
            <col width="90"/>
            <thead>
              <tr valign="top">
                <td>Theory</td>
                <td>Dependent variable</td>
                <td>Findings</td>
                <td>Reference</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>TAM<sup>a</sup>, integrated model, motivational model</td>
                <td>eHealth behavioral intention</td>
                <td><list list-type="bullet"><list-item><p>Users’ perceived technology usefulness, users’ perceived ease of use, intrinsic motivation, and extrinsic motivation have significant positive impact on behavioral intention</p></list-item><list-item><p>Integrated model does not have better results than TAM or motivational model when predicting behavioral intention</p></list-item></list></td>
                <td>[<xref ref-type="bibr" rid="ref25">25</xref>]</td>
              </tr>
              <tr valign="top">
                <td>UTAUT2<sup>b</sup> plus CFIP<sup>c</sup> (cross-country analysis: United States vs Portugal)</td>
                <td>Behavioral intention and use behavior in EHR<sup>d</sup> portals</td>
                <td><list list-type="bullet"><list-item><p>Behavioral intention drivers are performance expectancy, effort expectancy, social influence, hedonic motivation, price value, and habit. The predictors of use behavior are habit and behavioral intention</p></list-item><list-item><p>Social influence, hedonic motivation, and price value are only predictors in the US group</p></list-item><list-item><p>Confidentiality issues do not seem to influence acceptance</p></list-item></list></td>
                <td>[<xref ref-type="bibr" rid="ref27">27</xref>]</td>
              </tr>
              <tr valign="top">
                <td>TAM, Trust and Privacy</td>
                <td>Intention to adopt eHealth</td>
                <td><list list-type="bullet"><list-item><p>Perceived ease of use, perceived technology usefulness, and trust are significant predictors</p></list-item></list></td>
                <td>[<xref ref-type="bibr" rid="ref22">22</xref>]</td>
              </tr>
              <tr valign="top">
                <td>UTAUT2</td>
                <td>Behavioral intention and use behavior in EHR portals</td>
                <td><list list-type="bullet"><list-item><p>The behavioral intention drivers are performance expectancy, effort expectancy, social influence, and habit</p></list-item><list-item><p>Habit and behavioral intention are drivers of use behavior</p></list-item></list></td>
                <td>[<xref ref-type="bibr" rid="ref7">7</xref>]</td>
              </tr>
              <tr valign="top">
                <td>DOI<sup>e</sup> (mix of qualitative and quantitative study)</td>
                <td>Adoption rate of an e-appointment scheduling service</td>
                <td><list list-type="bullet"><list-item><p>The influence of the perceived attributes of the e-appointment scheduling service according to the DOI theory helps explaining the low adoption and use</p></list-item><list-item><p>Low socioeconomic status and lower educational level negatively influence the e-appointment scheduling service adoption rate</p></list-item></list></td>
                <td>[<xref ref-type="bibr" rid="ref13">13</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Extended TAM in health information technology</td>
                <td>Health information technology behavioral intention</td>
                <td><list list-type="bullet"><list-item><p>Perceived ease of use, perceived technology usefulness, and perceived threat significantly influenced health consumer behavioral intention</p></list-item></list></td>
                <td>[<xref ref-type="bibr" rid="ref23">23</xref>]</td>
              </tr>
              <tr valign="top">
                <td>UTAUT2 extended model</td>
                <td>Behavioral intention and use behavior in EHR portals</td>
                <td><list list-type="bullet"><list-item><p>Effort expectancy, performance expectancy, habit, and self-perception are predictors of behavioral intention</p></list-item><list-item><p>Habit and behavioral intention are predictors of use behavior</p></list-item></list></td>
                <td>[<xref ref-type="bibr" rid="ref2">2</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Institutional theory and UTAUT<sup>f</sup></td>
                <td>Patient portal use behavior</td>
                <td><list list-type="bullet"><list-item><p>Coercive and mimetic pressures significantly influence patient portal use behavior</p></list-item><list-item><p>Normative pressure was found to be not relevant</p></list-item></list></td>
                <td>[<xref ref-type="bibr" rid="ref28">28</xref>]</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>TAM: technology adoption model.</p>
            </fn>
            <fn id="table1fn2">
              <p><sup>b</sup>UTAUT2: extended unified theory of adoption and use of technology.</p>
            </fn>
            <fn id="table1fn3">
              <p><sup>c</sup>CFIP: concern for information privacy.</p>
            </fn>
            <fn id="table1fn4">
              <p><sup>d</sup>EHR: electronic health record.</p>
            </fn>
            <fn id="table1fn5">
              <p><sup>e</sup>DOI: diffusion of innovation.</p>
            </fn>
            <fn id="table1fn6">
              <p><sup>f</sup>UTAUT: unified theory of adoption and use of technology.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <p>Although EHR portals are consumer-oriented technologies, because a patient can be viewed as a health care consumer, the use of a model like UTAUT2 should not be regarded sufficient to explain the complexity of EHR portal adoption [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref26">26</xref>]. Several studies that used constructs or frameworks related to the HBM demonstrated their usefulness and statistical significance in explaining health information consumer adoption [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]. The HBM advocates that belief in health risk predicts the likelihood of engaging in health behavior, or an alternative way to look into it is to consider that the perceived severity, instead of the real severity, of the health complaint could be the driving force behind the action [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref30">30</xref>]. Evidence in the literature shows that the global usage of EHR portals is still limited [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref31">31</xref>].</p>
        <p>As the rate of adoption is still low in the use of EHR portals, literature that has addressed the eHealth patient technologies under the scope of DOI also mentioned a low level of global use and identified the users as early adopters [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref32">32</xref>]. Earlier studies that focused on understanding eHealth patient-centered technologies and EHR portals identified both performance expectancy and effort expectancy as important predictors of behavioral intention to use [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref25">25</xref>]. Both performance expectancy and effort expectancy have their equivalents within DOI theory as relative advantage and complexity [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref33">33</xref>], providing another strong argument to use DOI theory when studying EHR portals [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref13">13</xref>]. This study included intention to recommend as a dependent variable. According to our knowledge, this is the first time that intention to recommend is studied in the field of the adoption of EHR portals [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref33">33</xref>]. Understanding whether current users of new technologies that have a low level of adoption can be used to promote them is a valuable asset that should be evaluated [<xref ref-type="bibr" rid="ref33">33</xref>].</p>
      </sec>
      <sec>
        <title>Research Model</title>
        <p>As EHR portals are a new technology focused on consumer health [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>], our research model is a combination of UTAUT2 [<xref ref-type="bibr" rid="ref26">26</xref>], self-perception, a construct from the HBM [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>], and a framework based on the DOI model [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref36">36</xref>]. On the basis of the extensive literature review and previous studies, the need to have a model with patient-centric focus was identified, something that UTAUT2 provides, with consumer-specific constructs and good results in previous eHealth and EHR portal studies [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. As we are studying the EHR portals from the heath care consumers’ perspective and not from the health care providers’ standpoint, it is relevant to use UTAUT2, because most of the existing (information technology) IT adoption models are not consumer-specific [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref15">15</xref>]. In addition, previous research identified the relevance of including health care–specific constructs in studying the adoption of EHR portals and eHealth platforms [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>]; therefore, we used a construct related to HBM that already achieved good results within the scope of our study [<xref ref-type="bibr" rid="ref3">3</xref>]. EHR portals are a new eHealth technology and the DOI model revealed in past studies to be able to explain the adoption of new eHealth tools successfully, therefore making it suitable to be used to study EHR portals adoption [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref18">18</xref>]. We also made some improvements in our research model concerning the theories we used. In the UTAUT2 framework, we did not use the construct hedonic motivation. Hedonic motivation is conceptualized as intrinsic motivation (eg, pleasure or enjoyment) [<xref ref-type="bibr" rid="ref26">26</xref>]. People use EHR portals frequently when they are ill [<xref ref-type="bibr" rid="ref1">1</xref>] and that can be viewed by many as not being an enjoyable activity [<xref ref-type="bibr" rid="ref37">37</xref>]. Recent literature confirms no consistent and relevant results in predicting the adoption of EHR portals with hedonic motivation [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref27">27</xref>]. Literature evidence shows that constructs related to the HBM, such as perceived health risk or self-perception, are much better motivation predictors of adoption of EHR portals than hedonic motivation [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref23">23</xref>]. We also used intention to recommend as a dependent variable. This is a variable that has not been used in the literature to explain the adoption of EHR portals [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref38">38</xref>]. Instead, it has been used in other technologies to explain adoptions such as mobile payments [<xref ref-type="bibr" rid="ref33">33</xref>], which were also regarded as relatively new and with a low usage level [<xref ref-type="bibr" rid="ref33">33</xref>] like EHR portals [<xref ref-type="bibr" rid="ref2">2</xref>]. In these types of technologies, providers start to rely on current or potential users to recommend them to others [<xref ref-type="bibr" rid="ref33">33</xref>]. That is why we included intention to recommend in our research model. <xref ref-type="fig" rid="figure1">Figure 1</xref> illustrates the new research model.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>The research model. DOI: diffusion of innovation; HBM: health belief model; UTAUT2: extended unified theory of acceptance and use of technology.</p>
          </caption>
          <graphic xlink:href="jmir_v20i11e11032_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Extended Unified Theory of Acceptance and Use of Technology Constructs</title>
        <p>Performance expectancy is theorized to be the degree to which using a specific technology provides benefits to consumers in executing particular tasks [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref39">39</xref>]. Overall, patients adopt and use more eHealth tools and EHR portals that provide benefits in executing online health-related activities [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref25">25</xref>]:</p>
        <disp-formula>H1: Performance expectancy will positively influence behavioral intention.</disp-formula>
        <p>Effort expectancy is the degree of ease connected to consumers’ usage of a certain technology [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref39">39</xref>]. The simpler it is for health care consumers to use an EHR portal, the greater is the likelihood that they will use it [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref25">25</xref>]:</p>
        <disp-formula>H2: Effort expectancy will positively influence behavioral intention.</disp-formula>
        <p>Social influence is the extent to which people acknowledge that others who are significant to them believe they should use a particular technology [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref25">25</xref>]. According to the literature, social influence plays a role in the adoption of eHealth and EHR portals, because patients with the same health issues tend to be induced by others sharing the same or similar condition [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>]:</p>
        <disp-formula>H3: Social influence will positively influence behavioral intention.</disp-formula>
        <p>Facilitating conditions refers to consumers’ awareness of the support and resources available to execute a particular behavior [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref39">39</xref>]. A possible barrier to patients’ use of eHealth tools is the nonexistence of resources or support services that enable them to access and use these types of technology, implying that health care consumers with better conditions favor EHR portals usage and adoption [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref42">42</xref>]:</p>
        <disp-formula>H4(a): Facilitating conditions will positively influence behavioral intention.</disp-formula>
        <disp-formula>H4(b): Facilitating conditions will positively influence use behavior.</disp-formula>
        <p>If we relate to the consumer environment, price value is a relevant dimension, because consumers usually bear the costs linked with purchasing products and services [<xref ref-type="bibr" rid="ref26">26</xref>]. If health care consumers can obtain the results of their medical examination online, for example, through an EHR portal, they save time and transportation costs by avoiding an unnecessary trip to a clinic or hospital [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref43">43</xref>]:</p>
        <disp-formula>H5: Price value will positively influence behavioral intention.</disp-formula>
        <p>Habit can be described as the degree to which people tend to perform behaviors automatically due to learning [<xref ref-type="bibr" rid="ref26">26</xref>]. According to recent literature, habit positively influences the use and adoption of eHealth tools and EHR portals [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref44">44</xref>]:</p>
        <disp-formula>H6(a): Habit will positively influence behavioral intention.</disp-formula>
        <disp-formula>H6(b): Habit will positively influence use behavior.</disp-formula>
        <p>The role of behavioral intention has been recognized in eHealth with the literature affirming that the driver of use and adoption of EHR portals is preceded by the behavioral intention to use them [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref27">27</xref>]:</p>
        <disp-formula>H10(a): Behavioral intention will positively influence use behavior.</disp-formula>
      </sec>
      <sec>
        <title>Health Behavior Construct</title>
        <p>Supporting the concept of self-perception is the HBM. HBM assumes that subjective health concerns determine whether individuals execute a health-related action such as making an appointment with their physician [<xref ref-type="bibr" rid="ref30">30</xref>]. Self-perception in health [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>] posits that the perceived (rather than the real) severity of the health complaint could be the driving force inducing the action [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref45">45</xref>].</p>
        <p>There is evidence in the literature that self-perception influences behavior intention to use eHealth tools and EHR portals [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref23">23</xref>]:</p>
        <disp-formula>H7(a): Self-perception will positively influence behavioral intention.</disp-formula>
        <p>There is also evidence in the literature that self-perception can not only drive intentions but also directly influence actions with regard to the use of health-related services [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref30">30</xref>]. Often with sensitive topics and particularly with health-related topics, a mismatch between intentions and effective actions may occur [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref46">46</xref>]. It is then also relevant to evaluate the potential positive effect of self-perception on use behavior:</p>
        <disp-formula>H7(b): Self-perception will positively influence use behavior.</disp-formula>
      </sec>
      <sec>
        <title>Diffusion of Innovation Constructs</title>
        <p>Roger’s DOI theory is one of the most acknowledged theories for studying IT adoption [<xref ref-type="bibr" rid="ref13">13</xref>]. According to DOI, innovation is an idea, technology, or a process that is perceived as unknown or new to a particular group of individuals [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref47">47</xref>]. Diffusion is how the information about the innovation is shared inside the social system [<xref ref-type="bibr" rid="ref47">47</xref>]. The attributes of an innovation comprise 5 user-perceived qualities: relative advantage, compatibility, complexity, trialability, and observability [<xref ref-type="bibr" rid="ref47">47</xref>]. Moore and Benbasat [<xref ref-type="bibr" rid="ref36">36</xref>] expanded the original set of innovation attributes proposed by DOI to be applicable to the IT setting. One example was the construct observability, which was subdivided into results demonstrability and visibility [<xref ref-type="bibr" rid="ref36">36</xref>]. Subsequent studies have found that results demonstrability is more relevant than visibility in predicting users’ intention to use a technology, particularly in IT health care [<xref ref-type="bibr" rid="ref32">32</xref>]. We did not measure trialability because there was no evidence that our target population has participated in a trial usage of EHR portals [<xref ref-type="bibr" rid="ref3">3</xref>]. EHR portals should be seen as a new technology that relates to the concept of an innovation in consumer IT within the scope of health care.</p>
        <p>Relative advantage is the extent to which the consumer perceives improvements or benefits upon the current technology by adopting an innovation [<xref ref-type="bibr" rid="ref47">47</xref>]. Relative advantage measures fundamentally the same thing as performance expectancy within the context of DOI [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref33">33</xref>]. Complexity measures the extent to which an innovation is difficult to understand or be used [<xref ref-type="bibr" rid="ref47">47</xref>]. We also find a commonality between effort expectancy and complexity [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref33">33</xref>]. Both relative advantage and complexity within the context of DOI, according to the literature, may be regarded as positively influencing the behavioral intention to adopt EHR portals [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref32">32</xref>].</p>
        <p>Results demonstrability is the degree to which the tangible results of adopting and using an innovation can be visible and then communicable [<xref ref-type="bibr" rid="ref36">36</xref>]. According to the literature, this may have a direct effect on the behavioral intention to use an EHR portal [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref32">32</xref>]. In addition, potential users can better comprehend the benefits of using a new eHealth technology when noticeable results of the tool are directly evident, advocating a positive connection between results demonstrability and performance expectancy [<xref ref-type="bibr" rid="ref32">32</xref>]. The degree to which a specific individual noticed the results of using an innovation to be demonstrable partially reflects belief in using the tool and more easily achieving the desired outcome [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref32">32</xref>]. Thus, we theorize and ground on the literature that results demonstrability will positively influence effort expectancy:</p>
        <disp-formula>H8(a): Results demonstrability will positively influence behavioral intention.</disp-formula>
        <disp-formula>H8(b): Results demonstrability will positively influence performance expectancy.</disp-formula>
        <disp-formula>H8(c): Results demonstrability will positively influence effort expectancy.</disp-formula>
        <p>Compatibility measures the extent to which an innovation is perceived as being aligned with the existing consumer lifestyle values and current and past experiences [<xref ref-type="bibr" rid="ref47">47</xref>]. Compatibility has demonstrated to be a predictor of the behavioral intention to adopt a new technology in general, and also in consumer eHealth [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref33">33</xref>]. Compatibility, also like results demonstrability, is an antecedent of performance expectancy and effort expectancy [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref33">33</xref>]. Users may perceive EHR portals to be more compatible if they see advantages in using them to manage specific health care activities without additional complexity [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref33">33</xref>]. Compatibility consequently strengthens performance expectancy, effort expectancy, and behavioral intention to use EHR portals [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref33">33</xref>]:</p>
        <disp-formula>H9(a): Compatibility will positively influence behavioral intention.</disp-formula>
        <disp-formula>H9(b): Compatibility will positively influence performance expectancy.</disp-formula>
        <disp-formula>H9(c): Compatibility will positively influence effort expectancy.</disp-formula>
      </sec>
      <sec>
        <title>Users’ Intention to Recommend Electronic Health Record Portals</title>
        <p>IT consumers with a greater intention to adopt a new technology are more likely to become users and to recommend that specific technology to others [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref48">48</xref>]. Often with sensitive topics and particularly with health-related topics, a mismatch between intentions and effective actions may occur [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref46">46</xref>], so it is especially relevant to independently measure how the behavioral intention and use behavior may influence the intention to recommend the use of EHR portals:</p>
        <disp-formula>H10(b): Behavioral intention will positively influence intention to recommend EHR portals to others.</disp-formula>
        <disp-formula>H11: Use behavior will positively influence intention to recommend EHR portals to others.</disp-formula>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Measurements</title>
        <p>All the items were adopted from the studies by Venkatesh et al [<xref ref-type="bibr" rid="ref26">26</xref>], Wilson and Lankton [<xref ref-type="bibr" rid="ref25">25</xref>], van de Kar et al [<xref ref-type="bibr" rid="ref30">30</xref>], Moore and Benbasat [<xref ref-type="bibr" rid="ref36">36</xref>], and Oliveira et al [<xref ref-type="bibr" rid="ref33">33</xref>], with minor changes to adapt to EHR portal technology. The items are exhibited in <xref ref-type="app" rid="app1">Multimedia Appendix 1</xref>. The questionnaire was delivered in Portuguese after being translated by a certified translator. To guarantee that the content did not lose its original meaning, a back-translation was made from Portuguese to English by a different certified translator and compared with the original [<xref ref-type="bibr" rid="ref49">49</xref>]. The scales’ items were measured on a 7-point range scale, ranging from “strongly disagree” (1) to “strongly agree” (7). Use behavior was measured on a different scale. The scale from UTAUT2—from “never” to “many times per day”—was adapted to “never” to “every time I need,” because EHR portal usage is not expected to be as regular as mobile internet usage. Sociodemographic questions were also included. Age was measured in years, and gender was coded as a dummy variable (0 or 1), with women represented by 0. Having a private health insurance was also coded as a dummy variable (0 or 1), with its absence represented by 0. Information about the level of education of the respondents was also assessed with 3 different layers (university degree, high school education complete, and high school education incomplete).</p>
      </sec>
      <sec>
      <title>Data Collection</title>
      <p>A pilot survey was performed to validate the questions and the scale of the survey. From the pilot survey, we had 20 responses. No issues were reported that could question the fact that the questionnaire items were not reliable. However, from the outcome of the pilot survey, there was strong evidence that our nonresponse rate in the main survey could be high (&gt;50%). The data from the pilot survey were not included in the main survey. As one of the goals of our study is to determine the usage prevalence rate of this type of technology, we subdivided our survey into 2 phases. Two-phase sampling designs are frequently used in epidemiological studies, in health care, when a disease is rare, and when the diagnosis of the disease is difficult or expensive [<xref ref-type="bibr" rid="ref50">50</xref>]. In the first phase, a bigger random sample from the targeted population is screened with less intensive and expensive screening. In the second stage, a random subsample of the individuals is studied more intensively [<xref ref-type="bibr" rid="ref50">50</xref>]. We used a similar approach; our target population is also infrequent, but in our case, the aim is to handle a potential high nonresponse rate. Specifically, our population of interest is the Portuguese adult population (age≥18 years) who are users of EHR portals. In the first section, we asked the potential respondent if she or he was a Portuguese adult. If the response was positive, we asked if she or he was a user of EHR portals, and only after identifying that she or he was a user, we asked about her or his interest in replying to our main survey. The EHR portal user is a current user of any of the 4 main functionalities that EHR portals can provide in general (management of health information and communication with health providers, medical appointments schedule, check their own EHR, and request for medical prescription renewals) [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref3">3</xref>-<xref ref-type="bibr" rid="ref7">7</xref>].</p>
      <fig id="figure2" position="float">
        <label>Figure 2</label>
        <caption>
          <p>Sampling procedure and results. EHR: electronic health record.</p>
        </caption>
        <graphic xlink:href="jmir_v20i11e11032_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
      </fig>
      <p>To interview our target population, we used a nationwide mobile phone survey. According to the latest research, 94.5% of the Portuguese adult population had a mobile phone by December 2016 [<xref ref-type="bibr" rid="ref51">51</xref>], making it a valuable approach to conduct this survey due to its high coverage of the target population. The survey was computer-assisted, and all answers were recorded immediately. The mobile phone sample consisted of randomly generated numbers. Portuguese mobile phone numbers are of 9 digits, and the first 2 digits identify the operator [<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref52">52</xref>].</p>  
      <p>The Portuguese Telecommunications Regulation Authority (ANACOM) delivers information concerning the market share of the 3 operators offering mobile services in Portugal [<xref ref-type="bibr" rid="ref51">51</xref>]. This was used to split the sample into 3 mobile subsamples proportional to the market share [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>].</p>
      <p>Within each 2-digit prefix of the 3 operators, numbers were created by a generator of 7-digit random numbers [<xref ref-type="bibr" rid="ref52">52</xref>]. Up to 4 additional call attempts were made to each number to establish contact, with the exceptions when the number was identified as nonworking or not attributed (a message from the operator provides this information) [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>]. The survey took place between July 25, 2017, and October 15, 2017. All study participants were informed about the research purpose, confidentiality protection, and the anonymity of the information collected and that by answering all the questions, they were giving their consent to participate in the survey. In total, we obtained 15,080 valid numbers. From this sample, we obtained a 71.0% response rate regarding the question to identify the users of EHR portals. From the ones that were eligible to answer the survey, we obtained 139 completed questionnaires and a response rate of 15.1% (see <xref ref-type="fig" rid="figure2">Figure 2</xref>).</p></sec>
      <sec>
        <title>Data Analysis</title>
        <p>To test our research model, we applied partial least squares structural equation modeling (PLS-SEM). The motivations for choosing this approach were the model complexity (many constructs and many indicators), formatively measured constructs are part of the structural model, and the fact that the PLS-SEM method is oriented to explain variance of the research model and to detect statistically significant constructs [<xref ref-type="bibr" rid="ref54">54</xref>-<xref ref-type="bibr" rid="ref56">56</xref>]. SmartPLS 3 [<xref ref-type="bibr" rid="ref57">57</xref>] was used to estimate the model. Before evaluating the structural model, we assessed the measurement model to evaluate construct reliability, indicator reliability, convergent validity, and discriminant validity.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Sample Characteristics</title>
        <p>The sample characteristics results versus the target population profile are displayed in <xref ref-type="table" rid="table2">Table 2</xref>.</p>
        <p>Age groups are from 2011census data [<xref ref-type="bibr" rid="ref58">58</xref>], the level of education uses the latest inquiry from the National Institute of Statistics in 2016 [<xref ref-type="bibr" rid="ref59">59</xref>] as a source, and for the number of people with private health insurance in Portugal, the information is from the Portuguese Association of Insurance Companies from 2016 [<xref ref-type="bibr" rid="ref60">60</xref>]. Except for the case of gender, all other sample characteristics differ from the target population. We should not generalize these results as representative of the target population due to the high nonresponse rate in the second phase (<xref ref-type="fig" rid="figure2">Figure 2</xref>). Early adopters in eHealth are usually younger and more educated than the general population, in line with the findings of our study [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref61">61</xref>]. Higher income is also related to eHealth early adopters, which may justify the higher percentage of people in our sample compared with the target population with private insurance [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref38">38</xref>]. In Portugal, there is a NHS that provides coverage to all citizens, but in the last decade, there was a substantial increase in the number of people obtaining complementary private health insurance [<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref63">63</xref>]. In Portugal, the main private health care institutions have also implemented measures to encourage the use of eHealth tools, including EHR portals [<xref ref-type="bibr" rid="ref7">7</xref>].</p>
        <p>We also assessed the common method variance initially using Harman one-factor test. If the total variance for a single factor is less than 50%, it suggests that common method variance is not an issue [<xref ref-type="bibr" rid="ref64">64</xref>]. The greatest variance (47.16%) explained by 1 factor was, in our case by the first one, still lower than 50%. Subsequently, the marker-variable technique was applied, in which we used a theoretical unrelated construct, the marker variable [<xref ref-type="bibr" rid="ref65">65</xref>]. We found no significant correlation between the research model constructs and the marker variable. Therefore, we can conclude that common method variance was not a serious problem, verified by 2 different and established criteria [<xref ref-type="bibr" rid="ref64">64</xref>-<xref ref-type="bibr" rid="ref66">66</xref>].</p>
      </sec>
      <sec>
        <title>Usage Results</title>
        <p>According to the results in the first stage of our inquiry, 8.6% of the Portuguese adult population uses EHR portals. This value is within the range of 5%-10%, most commonly reported in the literature [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. We obtained a response rate of 71.0% in the first stage. In the case of our survey, we cannot assume that the nonresponses are <italic>missing at random</italic>, and hence, their lack may lead to a bias [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]. According to the literature, the ideal value for responses in a survey should be greater than or equal to 80% to make assumptions about the results and be representative of the population [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]. The types of nonresponses in our survey are included in <xref ref-type="fig" rid="figure2">Figure 2</xref>. They include 4.0% of individuals who were ineligible, mostly because their age was less than 18 years. Overall, according to other surveys in general and surveys for populations of low prevalence, our response rate may be regarded as reasonable [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref71">71</xref>].</p>
        <p>The usage patterns reported in <xref ref-type="table" rid="table3">Table 3</xref> show a good adoption and usage by the users. The feature with the least usage is the request for medical prescription renewals; our sample is relatively young (mean age: 36.0 years). The request for prescription renewals is usually related with chronic conditions that are more prevalent among older people [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref72">72</xref>]. The descriptive statistics of the other questionnaire items are provided in <xref ref-type="app" rid="app1">Multimedia Appendix 1</xref>.</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Sample characteristics versus target population.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="450"/>
            <col width="180"/>
            <col width="250"/>
            <col width="90"/>
            <thead>
              <tr valign="bottom">
                <td colspan="2">Characteristics</td>
                <td>Sample (n=139), n (%)</td>
                <td>Population, (n=8,657,240)<sup>a</sup>, n (%)</td>
                <td><italic>P</italic> value<sup>b</sup></td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="2"><bold>Age (in years)</bold></td>
                <td><break/></td>
                <td><break/></td>
                <td><bold>&lt;.001</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>18-34</td>
                <td>67 (48.2)</td>
                <td>2,243,957 (25.92)</td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>35-49</td>
                <td>58 (41.7)</td>
                <td>2,367,755 (27.35)</td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>50-64</td>
                <td>8 (5.8)</td>
                <td>2,035,317 (23.51)</td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>≥65</td>
                <td>6 (4.3)</td>
                <td>2,010,211 (23.22)</td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td colspan="2"><bold>Gender</bold></td>
                <td><break/></td>
                <td><break/></td>
                <td><bold>.81</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Male</td>
                <td>64 (46.0)</td>
                <td>4,072,366 (47.04)</td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Female</td>
                <td>75 (54.0)</td>
                <td>4,584,874 (52.96)</td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td colspan="2"><bold>Private health insurance</bold></td>
                <td><break/></td>
                <td><break/></td>
                <td><bold>&lt;.001</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Yes</td>
                <td>78 (56.1)</td>
                <td>2,172,967 (25.10)</td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>No</td>
                <td>61 (43.9)</td>
                <td>6,484,273 (74.90)</td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td colspan="2"><bold>Education</bold></td>
                <td><break/></td>
                <td><break/></td>
                <td><bold>&lt;.001</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>University degree</td>
                <td>88 (63.3)</td>
                <td>1,576,483 (18.21)</td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Nonuniversity degree</td>
                <td>51 (36.7)</td>
                <td>7,080,757 (81.79)</td>
                <td><break/></td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table2fn1">
              <p><sup>a</sup>Portuguese census 2011 adult population.</p>
            </fn>
            <fn id="table2fn3">
              <p><sup>b</sup><italic>χ</italic><sup>2</sup> test.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Electronic health record portals’ usage patterns.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="600"/>
            <col width="100"/>
            <col width="100"/>
            <col width="100"/>
            <col width="100"/>
            <thead>
              <tr valign="top">
                <td>Use indicators</td>
                <td>Average</td>
                <td>Median</td>
                <td>Minimum</td>
                <td>Maximum</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>UB1: Management of personal information and communication with health providers</td>
                <td>4.37</td>
                <td>5.00</td>
                <td>1.00</td>
                <td>7.00</td>
              </tr>
              <tr valign="top">
                <td>UB2: Medical appointments schedule</td>
                <td>4.75</td>
                <td>5.00</td>
                <td>1.00</td>
                <td>7.00</td>
              </tr>
              <tr valign="top">
                <td>UB3: Check their own electronic health record</td>
                <td>4.56</td>
                <td>5.00</td>
                <td>1.00</td>
                <td>7.00</td>
              </tr>
              <tr valign="top">
                <td>UB4: Request for medical prescription renewals</td>
                <td>3.34</td>
                <td>3.00</td>
                <td>1.00</td>
                <td>7.00</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
      <sec>
      <title>Measurement Model</title>
      <p>Typically, the first criterion to be assessed is construct reliability or internal consistency reliability. It is traditionally evaluated by Cronbach alpha, which delivers an estimation of the reliability grounded on the intercorrelations of the observed indicator variables [<xref ref-type="bibr" rid="ref54">54</xref>]. Cronbach alpha assumes that all indicators are equally reliable. However, PLS-SEM prioritizes the indicators according to their individual reliability [<xref ref-type="bibr" rid="ref54">54</xref>]. Due to Cronbach alpha’s stated limitations, it is technically more suitable to apply an alternative measure for the same purpose, which is mentioned to as composite reliability [<xref ref-type="bibr" rid="ref54">54</xref>]. The composite reliability measure takes into account the different indicator variables’ outer loadings [<xref ref-type="bibr" rid="ref54">54</xref>]. <xref ref-type="table" rid="table4">Table 4</xref> shows that all constructs have composite reliability higher than .70, showing evidence of internal consistency [<xref ref-type="bibr" rid="ref26">26</xref>].</p>
      <p>The most commonly used PLS-SEM measure to access convergent validity on the construct level is the average variance extracted (AVE) [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]. According to the literature, we should aim to an AVE value of .50 or greater, meaning that on average, the construct explains more than 50% of the variance of its indicators [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]. The results in <xref ref-type="table" rid="table4">Table 4</xref> demonstrate that this criterion is fully achieved. In addition, to evaluate indicator reliability, a well-known rule of thumb is that a latent variable should explain a significant part of each indicator’s variance, ideally at least half [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref73">73</xref>]. This means that an indicator’s outer loading should be greater than or equal to .70 [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref73">73</xref>]. Nevertheless, indicators with outer loadings between .40 and .70 should be removed only when deleting the indicators leads to an increase in the AVE or the composite reliability above the suggested threshold value [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>].</p>  
      <p>Only 1 indicator was removed SP4, with an outer loading below .40. All other indicators have an outer loading higher than .70, and they are shown in <xref ref-type="app" rid="app2">Multimedia Appendix 2</xref>.</p>
      <p>Discriminant validity is the degree to which a construct is truly dissimilar from the other constructs in the model [<xref ref-type="bibr" rid="ref54">54</xref>]. Traditionally, researchers have relied on 2 measures of discriminant validity [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]. One is the Fornell-Larcker criterion that compares the square root of the AVE values with the latent variables’ correlations. Particularly, the square root of each construct’s AVE should be greater than its highest correlation with any other construct [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>], and as seen in <xref ref-type="table" rid="table5">Table 5</xref>, this criterion is met. The other traditional measure of discriminant validity is the cross-loadings. Particularly, an indicator’s outer loading on the associated construct should be higher than any of its cross-loadings on other constructs [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]. This criterion is also met, as seen in <xref ref-type="app" rid="app2">Multimedia Appendix 2</xref>. Recent research suggests the use of an alternative criterion, the heterotrait-monotrait ratio (HTMT) of the correlations. HTMT is the ratio of the between-trait correlations to the within-trait correlation [<xref ref-type="bibr" rid="ref54">54</xref>]. Ideally, the HTMT value should be different from 1; prior research suggests a threshold value of .90 [<xref ref-type="bibr" rid="ref54">54</xref>]. Ideally, to avoid any ambiguity, the most recent research applied a procedure called bootstrapping to derive a distribution of the HTMT statistic and to determine if it is significantly different from 1 [<xref ref-type="bibr" rid="ref54">54</xref>]. With this procedure, it is feasible to derive a bootstrap CI (eg, 95%). A CI including the value 1 indicates a lack of discriminant validity. On the contrary, if the value 1 falls outside the interval’s range, this advocates that the 2 constructs are empirically different [<xref ref-type="bibr" rid="ref54">54</xref>]. This criterion is also met for our model, as seen in <xref ref-type="app" rid="app2">Multimedia Appendix 2</xref>.</p>
      <p>Use behavior, which was modeled using 4 formative indicators, is evaluated by specific quality criteria linked to formative indicators [<xref ref-type="bibr" rid="ref54">54</xref>]. A recently proposed way to evaluate the formative construct’s validity is to examine its correlation with an alternative measure of the construct, using a global single item or reflective measures (redundancy analysis). The strength of the path coefficients linking the 2 constructs should be at least .70 [<xref ref-type="bibr" rid="ref54">54</xref>]. In our study, we used a global single item for use behavior, obtaining a path coefficient of .851, thus confirming the convergent validity for the use behavior formatively measured construct. In addition, we need to assess the formative indicators for potential collinearity issues. As seen in <xref ref-type="table" rid="table6">Table 6</xref>, all variance inflation factors are below 5, meaning that collinearity is not an issue [<xref ref-type="bibr" rid="ref54">54</xref>]. An additional relevant criterion for evaluating the contribution of a formative indicator is its weight to be statistically significant, or in case it is not significant, its outer loading must be greater than .50 [<xref ref-type="bibr" rid="ref54">54</xref>]. All formative indicators comply with these assumptions, as shown in <xref ref-type="table" rid="table6">Table 6</xref>.</p>
      <table-wrap position="float" id="table4">
        <label>Table 4</label>
        <caption>
          <p>Cronbach alpha, composite reliability, and average variance extracted.</p>
        </caption>
        <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
          <col width="480"/>
          <col width="160"/>
          <col width="170"/>
          <col width="200"/>
          <thead>
            <tr valign="top">
              <td>Constructs</td>
              <td>Cronbach alpha</td>
              <td>Composite reliability</td>
              <td>Average variance extracted</td>
            </tr>
          </thead>
          <tbody>
            <tr valign="top">
              <td>Behavior intention</td>
              <td>.929</td>
              <td>.955</td>
              <td>.876</td>
            </tr>
            <tr valign="top">
              <td>Compatibility</td>
              <td>.936</td>
              <td>.955</td>
              <td>.841</td>
            </tr>
            <tr valign="top">
              <td>Effort expectancy</td>
              <td>.897</td>
              <td>.929</td>
              <td>.767</td>
            </tr>
            <tr valign="top">
              <td>Facilitating condition</td>
              <td>.822</td>
              <td>.883</td>
              <td>.655</td>
            </tr>
            <tr valign="top">
              <td>Habit</td>
              <td>.876</td>
              <td>.924</td>
              <td>.803</td>
            </tr>
            <tr valign="top">
              <td>Intention to recommend</td>
              <td>.879</td>
              <td>.942</td>
              <td>.891</td>
            </tr>
            <tr valign="top">
              <td>Performance expectancy</td>
              <td>.863</td>
              <td>.917</td>
              <td>.786</td>
            </tr>
            <tr valign="top">
              <td>Price value</td>
              <td>.953</td>
              <td>.970</td>
              <td>.915</td>
            </tr>
            <tr valign="top">
              <td>Results demonstrability</td>
              <td>.880</td>
              <td>.926</td>
              <td>.806</td>
            </tr>
            <tr valign="top">
              <td>Social influence</td>
              <td>.958</td>
              <td>.973</td>
              <td>.923</td>
            </tr>
            <tr valign="top">
              <td>Self-perception</td>
              <td>.817</td>
              <td>.893</td>
              <td>.739</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <table-wrap position="float" id="table5">
        <label>Table 5</label>
        <caption>
          <p>Correlations and square roots of all average variance extracted in the model. Diagonal elements are square roots of all average variance extracted, and off-diagonal elements are correlations.</p>
        </caption>
        <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
          <col width="370"/>
          <col width="50"/>
          <col width="50"/>
          <col width="50"/>
          <col width="50"/>
          <col width="50"/>
          <col width="50"/>
          <col width="50"/>
          <col width="50"/>
          <col width="50"/>
          <col width="50"/>
          <col width="50"/>
          <col width="80"/>
          <thead>
            <tr valign="top">
              <td>Constructs</td>
              <td>BI</td>
              <td>CO</td>
              <td>EE</td>
              <td>FC</td>
              <td>HT</td>
              <td>IR</td>
              <td>PE</td>
              <td>PV</td>
              <td>RD</td>
              <td>SI</td>
              <td>SP</td>
              <td>UB</td>
            </tr>
          </thead>
          <tbody>
            <tr valign="top">
              <td>Behavioral intention (BI)</td>
              <td><italic>.936</italic></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Compatibility (CO)</td>
              <td>.809</td>
              <td><italic>.917</italic></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Effort expectancy (EE)</td>
              <td>.561</td>
              <td>.645</td>
              <td><italic>.876</italic></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Facilitating conditions (FC)</td>
              <td>.605</td>
              <td>.644</td>
              <td>.674</td>
              <td><italic>.809</italic></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Habit (HT)</td>
              <td>.703</td>
              <td>.616</td>
              <td>.541</td>
              <td>.534</td>
              <td><italic>.896</italic></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Intention to recommend (IR)</td>
              <td>.826</td>
              <td>.779</td>
              <td>.610</td>
              <td>.593</td>
              <td>.585</td>
              <td><italic>.944</italic></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Performance expectancy (PE)</td>
              <td>.695</td>
              <td>.651</td>
              <td>.481</td>
              <td>.468</td>
              <td>.537</td>
              <td>.648</td>
              <td><italic>.887</italic></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Price value (PV)</td>
              <td>.554</td>
              <td>.581</td>
              <td>.510</td>
              <td>.408</td>
              <td>.683</td>
              <td>.537</td>
              <td>.462</td>
              <td><italic>.956</italic></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Results demonstrability (RD)</td>
              <td>.615</td>
              <td>.763</td>
              <td>.660</td>
              <td>.581</td>
              <td>.556</td>
              <td>.635</td>
              <td>.528</td>
              <td>.521</td>
              <td><italic>.898</italic></td>
              <td><break/></td>
              <td><break/></td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Social influence (SI)</td>
              <td>.487</td>
              <td>.415</td>
              <td>.415</td>
              <td>.321</td>
              <td>.574</td>
              <td>.490</td>
              <td>.494</td>
              <td>.409</td>
              <td>.374</td>
              <td><italic>.961</italic></td>
              <td><break/></td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Self-perception (SP)</td>
              <td>.514</td>
              <td>.432</td>
              <td>.224</td>
              <td>.333</td>
              <td>.552</td>
              <td>.401</td>
              <td>.494</td>
              <td>.243</td>
              <td>.449</td>
              <td>.380</td>
              <td><italic>.860</italic></td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Use behavior (UB)</td>
              <td>.682</td>
              <td>.565</td>
              <td>.491</td>
              <td>.494</td>
              <td>.721</td>
              <td>.625</td>
              <td>.554</td>
              <td>.516</td>
              <td>.508</td>
              <td>.534</td>
              <td>.596</td>
              <td>formative</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <table-wrap position="float" id="table6">
        <label>Table 6</label>
        <caption>
          <p>Formative indicators’ quality criteria.</p>
        </caption>
        <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
          <col width="530"/>
          <col width="200"/>
          <col width="150"/>
          <col width="120"/>
          <thead>
            <tr valign="bottom">
              <td>Indicators</td>
              <td>Variance inflation factor</td>
              <td><italic>t</italic> value (weights)<sup>a,b</sup></td>
              <td>Outer loadings</td>
            </tr>
          </thead>
          <tbody>
            <tr valign="top">
              <td>UB1: Management of personal information and communication with health providers</td>
              <td>1.976</td>
              <td>4.923<sup>a</sup></td>
              <td>.892</td>
            </tr>
            <tr valign="top">
              <td>UB2: Medical appointment schedule</td>
              <td>2.432</td>
              <td>4.475<sup>a</sup></td>
              <td>.860</td>
            </tr>
            <tr valign="top">
              <td>UB3: Check their own electronic health record</td>
              <td>3.401</td>
              <td>0.753</td>
              <td>.800</td>
            </tr>
            <tr valign="top">
              <td>UB4: Request for medical prescription renewals</td>
              <td>1.566</td>
              <td>1.791</td>
              <td>.660</td>
            </tr>
          </tbody>
        </table>
        <table-wrap-foot>
          <fn id="table6fn1">
            <p><sup>a</sup><italic>P</italic>&lt;.01.</p>
          </fn>
        </table-wrap-foot>
        <table-wrap-foot>
          <fn id="table6fn2">
            <p><sup>b</sup><italic>P</italic>&lt;.05.</p>
          </fn>
        </table-wrap-foot>
      </table-wrap>
      <p>Considering all the results and findings, all reflective and formative constructs exhibit satisfactory levels of quality. Thus, we can proceed with the evaluation of the structural model.</p></sec>
      <sec>
        <title>Structural Model</title>
        <p>Structural model path significance levels were estimated using a bootstrap with 5000 iterations of resampling to obtain the maximum possible consistency in the results [<xref ref-type="bibr" rid="ref54">54</xref>]. We checked the structural model for collinearity issues by examining the variance inflation factor values of all sets of predictor constructs, and all variance inflation factor values are below the threshold of 5. Therefore, collinearity is not a critical issue in the structural model [<xref ref-type="bibr" rid="ref54">54</xref>]. To assess the structural model we used the <italic>R</italic><sup>2</sup>, path coefficients significance, and the <italic>f</italic><sup>2</sup> effect size [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]. The results are shown in <xref ref-type="table" rid="table7">Table 7</xref>. Overall, the model explains 76.0% of the variance in behavioral intention and 61.8% in use behavior, with these 2 being the most relevant dependent variables in our model. In addition to assessing the <italic>R</italic><sup>2</sup> values of all endogenous constructs, the change in the <italic>R</italic><sup>2</sup> value when a specific construct is removed from our model can be used to assess whether the construct has a substantial impact on the endogenous constructs [<xref ref-type="bibr" rid="ref54">54</xref>]. Guidelines for measuring <italic>f</italic><sup>2</sup> are that values of .02, .15, and .35, respectively, represent small, medium, and large effects of the exogenous latent variable; values of less than .02 denote that there is a null effect [<xref ref-type="bibr" rid="ref54">54</xref>]. Taking a particularly important role in our model, compatibility has a medium effect on both behavior intention and performance expectancy and a small effect on effort expectancy, showing the relevance of this construct in our research model. Another construct with a relevant role in our model is behavior intention, with a large effect on intention to recommend and a small effect on use behavior. Finally, habit is a construct that has a medium effect size on use behavior and a small effect size on behavior intention. With only small effect sizes, we have the effect of performance expectancy on behavior intention, self-perception on use behavior, results demonstrability on effort expectancy, and use behavior on intention to recommend; however, the last one is without a statistically significant path coefficient.</p>
        <table-wrap position="float" id="table7">
          <label>Table 7</label>
          <caption>
            <p>Structural model results and findings regarding hypotheses.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="460"/>
            <col width="50"/>
            <col width="50"/>
            <col width="70"/>
            <col width="100"/>
            <col width="120"/>
            <col width="50"/>
            <col width="70"/>
            <thead>
              <tr valign="bottom">
                <td colspan="2">Dependent and independent variables</td>
                <td><italic>f</italic><sup><italic>2</italic> </sup></td>
                <td>beta</td>
                <td><italic>t<sub>beta</sub></italic></td>
                <td>Hypothesis</td>
                <td>Results</td>
                <td><italic>R</italic><sup>2</sup></td>
                <td><italic>R</italic><sup>2</sup><sub>adj</sub></td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="7"><bold>Behavioral intention</bold></td>
                <td><bold>.760</bold></td>
                <td><bold>.743</bold></td>
              </tr>
              <tr valign="bottom">
                <td><break/></td>
                <td>Performance expectancy</td>
                <td>.081</td>
                <td>.203</td>
                <td>2.699<sup>a</sup></td>
                <td>H1</td>
                <td>Supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Effort expectancy</td>
                <td>.001</td>
                <td>−.022</td>
                <td>.311</td>
                <td>H2</td>
                <td>Not supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Social influence</td>
                <td>.002</td>
                <td>.025</td>
                <td>.450</td>
                <td>H3</td>
                <td>Not supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Facilitating conditions</td>
                <td>.014</td>
                <td>.086</td>
                <td>1.547</td>
                <td>H4(a)</td>
                <td>Not supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Price value</td>
                <td>.000</td>
                <td>−.015</td>
                <td>.277</td>
                <td>H5</td>
                <td>Not supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="bottom">
                <td><break/></td>
                <td>Habit</td>
                <td>.079</td>
                <td>.251</td>
                <td>2.660<sup>a</sup></td>
                <td>H6(a)</td>
                <td>Supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Self-perception</td>
                <td>.008</td>
                <td>.062</td>
                <td>.916</td>
                <td>H7(a)</td>
                <td>Not supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Results demonstrability</td>
                <td>.015</td>
                <td>−.102</td>
                <td>1.357</td>
                <td>H8(a)</td>
                <td>Not supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="bottom">
                <td><break/></td>
                <td>Compatibility</td>
                <td>.328</td>
                <td>.530</td>
                <td>6.189<sup>a</sup></td>
                <td>H9(a)</td>
                <td>Supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td colspan="7"><bold>Use behavior</bold></td>
                <td><bold>.618</bold></td>
                <td><bold>.607</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Facilitating conditions</td>
                <td>.005</td>
                <td>.056</td>
                <td>.727</td>
                <td>H4(b)</td>
                <td>Not supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="bottom">
                <td><break/></td>
                <td>Habit</td>
                <td>.165</td>
                <td>.378</td>
                <td>3.821<sup>a</sup></td>
                <td>H6(b)</td>
                <td>Supported</td>
                <td> </td>
                <td> </td>
              </tr>
              <tr valign="bottom">
                <td><break/></td>
                <td>Self-perception</td>
                <td>.095</td>
                <td>.233</td>
                <td>2.971<sup>a</sup></td>
                <td>H7(b)</td>
                <td>Supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="bottom">
                <td><break/></td>
                <td>Behavioral intention</td>
                <td>.075</td>
                <td>.263</td>
                <td>2.379<sup>b</sup></td>
                <td>H10(a)</td>
                <td>Supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td colspan="7"><bold>Intention to recommend</bold></td>
                <td><bold>.690</bold></td>
                <td><bold>.685</bold></td>
              </tr>
              <tr valign="bottom">
                <td><break/></td>
                <td>Behavioral intention</td>
                <td>.962</td>
                <td>.747</td>
                <td>10.737<sup>a</sup></td>
                <td>H10(b)</td>
                <td>Supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Use behavior</td>
                <td>.023</td>
                <td>.116</td>
                <td>1.565</td>
                <td>H11</td>
                <td>Not supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td colspan="7"><bold>Effort expectancy</bold></td>
                <td><bold>.483</bold></td>
                <td><bold>.476</bold></td>
              </tr>
              <tr valign="bottom">
                <td><break/></td>
                <td>Compatibility</td>
                <td>.092</td>
                <td>.337</td>
                <td>2.243<sup>b</sup></td>
                <td>H9(c)</td>
                <td>Supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="bottom">
                <td><break/></td>
                <td>Results demonstrability</td>
                <td>.131</td>
                <td>.403</td>
                <td>2.888<sup>a</sup></td>
                <td>H8(c)</td>
                <td>Supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td colspan="7"><bold>Performance expectancy</bold></td>
                <td><bold>.427</bold></td>
                <td><bold>.418</bold></td>
              </tr>
              <tr valign="bottom">
                <td><break/></td>
                <td>Compatibility</td>
                <td>.257</td>
                <td>.594</td>
                <td>6.141<sup>a</sup></td>
                <td>H9(b)</td>
                <td>Supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Results demonstrability</td>
                <td>.004</td>
                <td>.075</td>
                <td>.561</td>
                <td>H8(b)</td>
                <td>Not supported</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table7fn1">
              <p><sup>a</sup><italic>P</italic>&lt;.01.</p>
            </fn>
            <fn id="table7fn2">
              <p><sup>b</sup><italic>P</italic>&lt;.05.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>The results advocate that using our new research model in an eHealth-related area—EHR portal acceptance by patients—yields very good results, explaining 76.0% of the variance on behavioral intention and 61.8% of the variance in use behavior, the most relevant dependent variables in our model [<xref ref-type="bibr" rid="ref26">26</xref>]. We also obtained an <italic>R</italic><sup>2</sup> of 69.0% in intention to recommend, also a very good result [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref33">33</xref>]. Overall, the use of the 3 theories, UTAUT2, HBM, and DOI, was a successful strategy because in all of them we had constructs with statistically significant impact on explaining the adoption of EHR portals (see <xref ref-type="fig" rid="figure3">Figure 3</xref>). The constructs with the highest effect size in the model were compatibility, habit, and behavioral intention.</p>
      </sec>
      <sec>
        <title>Theoretical Implications</title>
        <p>In our model, performance expectancy has a statistically significant effect on behavior intention, suggesting that individuals care about the results and advantages that EHR portals can bring for them to manage their own health more effectively, supporting <italic>H1.</italic> This finding is supported by previous studies [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref27">27</xref>]. In regard to effort expectancy, there is no statistically significant impact, not supporting <italic>H2</italic>. This finding contradicts results from earlier studies that used effort expectancy as part of UTAUT2 [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref7">7</xref>], but in other studies also with new technologies and within health care, when effort expectancy is evaluated as part of DOI, it also obtained nonsignificant results [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref33">33</xref>]. A possible explanation, also supported by the literature, is that early adopters of new technologies have a higher cognitive ability and are more used to manage complexity and that they do not perceive it as an obstacle to use EHR portals [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref47">47</xref>].</p>
        <fig id="figure3" position="float">
          <label>Figure 3</label>
          <caption>
            <p>Structural model results. Note: path coefficients that are not statistically significant are in dashed arrows.</p>
          </caption>
          <graphic xlink:href="jmir_v20i11e11032_fig3.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <p>In our research model, social influence did not show a statistically significant effect on behavioral intention, thus not supporting <italic>H3</italic>. Previous studies have shown potential differences, with results differing among countries, with its positive significance being more consistent in the United States [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref28">28</xref>]. Potential cultural differences may explain the different behaviors. In our study, our early adopters of EHR portals seem to be more driven by their own individual willingness to try a new technology than to be influenced by what the society generally does. This is also an assumption supported by DOI theory [<xref ref-type="bibr" rid="ref47">47</xref>]. The nonconfirmation of the facilitating conditions hypothesis, <italic>H4(a)</italic> and <italic>H4(b),</italic> advocates that the individuals in our study believe that the resources or know-how to use EHR portals are not an issue. This can be justified by the ability of having access to a computer and the internet and is aligned with recent literature findings [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref44">44</xref>]. In Europe, access to most of the eHealth services is free of charge; so, the value that is provided to the patients is to permit them to execute specific activities more efficiently online. Unfortunately, that fact seems to be not acknowledged by the patients and <italic>H5</italic> was rejected. Habit has a statistically significant impact on both behavior intention and use behavior, supporting both <italic>H6(a)</italic> and <italic>H6(b)</italic>. Habit is a consumer-specific construct with a very significant role in our model, showing how important it is to have models tailored with consumer-specific constructs and not just general IT adoption constructs [<xref ref-type="bibr" rid="ref26">26</xref>], and it is also supported by recent literature findings [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref44">44</xref>].</p>
        <p>Self-perception has a statistically significant impact on use behavior, supporting <italic>H7(b)</italic>, and a nonsignificant impact on behavior intention, not supporting <italic>H7(a)</italic>. Often with sensitive topics and particularly with health-related topics, mismatch between intentions and effective actions occur [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref46">46</xref>]. In fact, this is the case with self-perception. Although it does not drive the intentions, self-perception directly influences actions in the usage of EHR portals. Results demonstrability has a statistically significant impact on effort expectancy, supporting <italic>H8(c)</italic>, and a nonsignificant impact on both performance expectancy <italic>H8(b)</italic> and behavior intention <italic>H8(a)</italic>, not supporting these 2 last hypotheses. Our results point out that when an innovation produces results that are readily discernible, perceptions of how easy it is to use a technology are considerably affected (this finding is in accordance with the literature [<xref ref-type="bibr" rid="ref32">32</xref>]), but not the perceptions related with performance expectancy or a direct influence on behavior intention. Compared with results demonstrability and also from DOI, compatibility has a much greater effect in our research model demonstrated not only by the <italic>f</italic><sup><italic>2</italic> </sup> but also by having all its paths in the model statistically significant. Compatibility has a statistically significant impact on behavior intention <italic>H9(a</italic>), performance expectancy <italic>H9(b)</italic>, and effort expectancy <italic>H9(c)</italic>, supporting these 3 hypotheses. The results indicate that behavior intention <italic>H9(a</italic>), performance expectancy <italic>H9(b)</italic>, and effort expectancy <italic>H9(c)</italic> are greater when the heath care consumer perceives the technology to be compatible. Our study’s results are in line with other studies in this regard [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref32">32</xref>]. Behavioral intention positively influences use behavior, supporting <italic>H10(a</italic>). This finding is in accordance with the literature suggesting that using EHR portals and eHealth tools is preceded by the intention to use them [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref44">44</xref>]. Behavioral intention also positively influences intention to recommend, supporting <italic>H10(b</italic>). Our model explains 69.0% of the variance in recommendation, and the findings validate the significant influence of behavioral intention over it. Nevertheless, use behavior does not have a significant impact on intention to recommend, not supporting <italic>H11</italic>. A probable explanation might be that being a high user does not necessarily link to higher recommendation, but that a strong intention to use, independent of the usage level, is a stronger predictor of intention to recommend.</p>
      </sec>
      <sec>
        <title>Managerial Implications</title>
        <p>The study identifies areas that may influence EHR portal adoption, regarding its conceptualization, implementation, and redesign. Performance expectancy is a significant adoption driver of EHR portals. Therefore, while conceiving and promoting EHR portals, it is relevant to emphasize the advantages that they provide to the users in managing their health-related activities more efficiently. It is also important when conceiving an EHR portal that results are easily demonstrable because perceptions of how easy a technology is to use are affected by them. Compatibility is a very important construct in our model, and it is important to develop EHR portals that fit the health care customers’ lifestyle. A good example is the providers that are already developing mobile versions of their EHR portals, allowing people to access their data everywhere [<xref ref-type="bibr" rid="ref7">7</xref>]. In addition to the automatic and direct effect of habit on usage, habit also operates as a stored intention path to influence behavior [<xref ref-type="bibr" rid="ref26">26</xref>]. This requires more communication effort to reinforce both the stored intention and its link to behavior [<xref ref-type="bibr" rid="ref26">26</xref>]. As habit has been defined as the degree to which individuals tend to execute behaviors automatically due to learning [<xref ref-type="bibr" rid="ref26">26</xref>], it is advisable that EHR portals have customer support services to help and provide support to the users with the platform.</p>
        <p>Another relevant outcome is that the construct that is specific to health care—self-perception—also has a statistically significant role on the EHR portals usage. Self-perception is linked to the fact that the perceived, rather than the real, severity of the health problem is the driving force behind the action [<xref ref-type="bibr" rid="ref30">30</xref>]. Health care interventions that enable the patient to be more conscious of her or his health condition may also endorse the usage of the EHR portal. In addition, the inclusion of educational health materials in the EHR portals may encourage patients to use the platform. Another important contribution of our study is to be able to demonstrate the influence of the intention to recommend in the adoption of EHR portals. Social network marketing and the opinions shared by friends and relatives are influential ways to help in the promotion and successful adoption of EHR portals. The managerial implications stated here are relevant not only for enhancing the adoption of EHR portals but also for growing the usage frequency of current users. These can be done by developing new EHR portals or by making improvements to existing ones.</p>
      </sec>
      <sec>
        <title>Limitations and Future Research</title>
        <p>Unfortunately, our study had a very high nonresponse rate concerning people that refused to answer the main questionnaire. With this high nonresponse rate, it is difficult to make direct assumptions related with the users in the Portuguese population. Nevertheless, earlier literature indicates that users and early users of eHealth tools and EHR portals are younger and more educated than the population average [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref61">61</xref>], in line with our study findings. The use of SEM is usually linked with the need of having questionnaires that are not short, making it more difficult for people to answer this questionnaire, especially by phone [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref73">73</xref>]. The use of gifts and other incentives may be a useful strategy to overcome the issue of the high nonresponse rate [<xref ref-type="bibr" rid="ref26">26</xref>]. Testing the research model with samples of EHR users from other countries may also be an interesting path to follow, as the literature has shown that multicountry assessment provides interesting and diverse insights [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref27">27</xref>]. We used PLS-SEM instead of covariance based-SEM for the following reasons [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref73">73</xref>]: we have a complex model (many constructs and many indicators), we had the goal of identifying key <italic>driver</italic> constructs, and we also verified that our data were non-normally distributed. We acknowledge that future research may go in the direction of using covariance based-SEM, which allows using global goodness-of-fit criteria, but due to the circumstances and the study goals, we adopted PLS-SEM in our research [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref73">73</xref>].</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>Although we acknowledge that we had a very high nonresponse rate in the second stage of our sampling procedure, the much lower nonresponse rate in the first stage provides an estimate of 8.6% usage of these types of platforms in Portugal, a valuable contribution from our study. Our respondents’ demographics follow the same trend as reported in other similar studies in the literature [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref61">61</xref>], providing additional support to our findings. Overall, the use of the 3 theories, UTAUT2, HBM, and DOI, to support our research was a successful strategy because in all of them, we had constructs with statistically significant impact on explaining the adoption of EHR portals. We were also able to demonstrate that consumers with a greater intention to adopt a new technology are more likely to become users and to recommend that specific technology to others. The new research model obtained very good results, with relevant <italic>R</italic><sup>2</sup> in the most important dependent variables that help to explain the adoption of EHR portals, behavior intention (76.0%), and use behavior (61.8%).</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <app id="app1">
        <title>Multimedia Appendix 1</title>
        <p>Questionnaire items.</p>
        <media xlink:href="jmir_v20i11e11032_app1.pdf" xlink:title="PDF File (Adobe PDF File), 103KB"/>
      </app>
      <app id="app2">
        <title>Multimedia Appendix 2</title>
        <p>Partial least squares loadings and cross-loadings plus CI for heterotrait-monotrait ratio.</p>
        <media xlink:href="jmir_v20i11e11032_app2.pdf" xlink:title="PDF File (Adobe PDF File), 139KB"/>
      </app>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">AVE</term>
          <def>
            <p>average variance extracted</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">CFIP</term>
          <def>
            <p>concern for information privacy</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">DOI</term>
          <def>
            <p>diffusion of innovation</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">EHR</term>
          <def>
            <p>electronic health record</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">epSOS</term>
          <def>
            <p>European patients smart open services</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">HBM</term>
          <def>
            <p>health belief model</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">HTMT</term>
          <def>
            <p>heterotrait-monotrait ratio</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb8">IT</term>
          <def>
            <p>information technology</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb9">NHS</term>
          <def>
            <p>National Health Service</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb10">PLS-SEM</term>
          <def>
            <p>partial least squares structural equation modeling</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb11">TAM</term>
          <def>
            <p>technology acceptance model</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb12">UTAUT</term>
          <def>
            <p>unified theory of acceptance and use of technology</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb13">UTAUT2</term>
          <def>
            <p>extended unified theory of acceptance and use of technology</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ancker</surname>
            <given-names>JS</given-names>
          </name>
          <name name-style="western">
            <surname>Barrón</surname>
            <given-names>Y</given-names>
          </name>
          <name name-style="western">
            <surname>Rockoff</surname>
            <given-names>ML</given-names>
          </name>
          <name name-style="western">
            <surname>Hauser</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Pichardo</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Szerencsy</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Calman</surname>
            <given-names>N</given-names>
          </name>
        </person-group>
        <article-title>Use of an electronic patient portal among disadvantaged populations</article-title>
        <source>J Gen Intern Med</source>  
        <year>2011</year>  
        <month>10</month>  
        <volume>26</volume>  
        <issue>10</issue>  
        <fpage>1117</fpage>  
        <lpage>23</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/21647748"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1007/s11606-011-1749-y</pub-id>
        <pub-id pub-id-type="medline">21647748</pub-id>
        <pub-id pub-id-type="pmcid">PMC3181304</pub-id></nlm-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Tavares</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Oliveira</surname>
            <given-names>T</given-names>
          </name>
        </person-group>
        <article-title>Electronic health record patient portal adoption by health care consumers: an acceptance model and survey</article-title>
        <source>J Med Internet Res</source>  
        <year>2016</year>  
        <month>03</month>  
        <volume>18</volume>  
        <issue>3</issue>  
        <fpage>e49</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://www.jmir.org/2016/3/e49/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.5069</pub-id>
        <pub-id pub-id-type="medline">26935646</pub-id>
        <pub-id pub-id-type="pii">v18i3e49</pub-id>
        <pub-id pub-id-type="pmcid">PMC4795321</pub-id></nlm-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <nlm-citation citation-type="book">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Tavares</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Oliveira</surname>
            <given-names>T</given-names>
          </name>
        </person-group>
        <person-group person-group-type="editor">
          <name name-style="western">
            <surname>Cruz Cunha</surname>
            <given-names>MM</given-names>
          </name>
          <name name-style="western">
            <surname>Miranda</surname>
            <given-names>IM</given-names>
          </name>
          <name name-style="western">
            <surname>Martinho</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Rijo</surname>
            <given-names>R</given-names>
          </name>
        </person-group>
        <article-title>Electronic health record portals definition and usage</article-title>
        <source>Encyclopedia of E-Health and Telemedicine</source>  
        <year>2016</year>  
        <publisher-loc>Hershey, PA, USA</publisher-loc>
        <publisher-name>IGI Global</publisher-name>
        <fpage>555</fpage>  
        <lpage>62</lpage> </nlm-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Angst</surname>
            <given-names>CM</given-names>
          </name>
          <name name-style="western">
            <surname>Agarwal</surname>
            <given-names>R</given-names>
          </name>
        </person-group>
        <article-title>Adoption of electronic health records in the presence of privacy concerns: the elaboration likelihood model and individual persuasion</article-title>
        <source>MIS Q</source>  
        <year>2009</year>  
        <volume>33</volume>  
        <issue>2</issue>  
        <fpage>339</fpage>  
        <lpage>70</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="https://www3.nd.edu/~cangst/CoreyAngst_FacultyWebsite_files/Angst2009MISQ.pdf"/>
        </comment> </nlm-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Kern</surname>
            <given-names>LM</given-names>
          </name>
          <name name-style="western">
            <surname>Edwards</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Kaushal</surname>
            <given-names>R</given-names>
          </name>
          <collab>HITEC Investigators</collab>
        </person-group>
        <article-title>The meaningful use of electronic health records and health care quality</article-title>
        <source>Am J Med Qual</source>  
        <year>2015</year>  
        <month>08</month>  
        <volume>30</volume>  
        <issue>6</issue>  
        <fpage>512</fpage>  
        <lpage>9</lpage>  
        <pub-id pub-id-type="doi">10.1177/1062860614546547</pub-id>
        <pub-id pub-id-type="medline">25122006</pub-id>
        <pub-id pub-id-type="pii">1062860614546547</pub-id></nlm-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Blumenthal</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Tavenner</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>The "meaningful use" regulation for electronic health records</article-title>
        <source>N Engl J Med</source>  
        <year>2010</year>  
        <month>08</month>  
        <day>5</day>  
        <volume>363</volume>  
        <issue>6</issue>  
        <fpage>501</fpage>  
        <lpage>4</lpage>  
        <pub-id pub-id-type="doi">10.1056/NEJMp1006114</pub-id>
        <pub-id pub-id-type="medline">20647183</pub-id>
        <pub-id pub-id-type="pii">NEJMp1006114</pub-id></nlm-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Tavares</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Goulão</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Oliveira</surname>
            <given-names>T</given-names>
          </name>
        </person-group>
        <article-title>Electronic health record portals adoption: empirical model based on UTAUT2</article-title>
        <source>Inform Health Soc Care</source>  
        <year>2018</year>  
        <month>03</month>  
        <volume>43</volume>  
        <issue>2</issue>  
        <fpage>109</fpage>  
        <lpage>25</lpage>  
        <pub-id pub-id-type="doi">10.1080/17538157.2017.1363759</pub-id>
        <pub-id pub-id-type="medline">29035646</pub-id></nlm-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Alpay</surname>
            <given-names>LL</given-names>
          </name>
          <name name-style="western">
            <surname>Henkemans</surname>
            <given-names>OB</given-names>
          </name>
          <name name-style="western">
            <surname>Otten</surname>
            <given-names>W</given-names>
          </name>
          <name name-style="western">
            <surname>Rövekamp</surname>
            <given-names>TA</given-names>
          </name>
          <name name-style="western">
            <surname>Dumay</surname>
            <given-names>AC</given-names>
          </name>
        </person-group>
        <article-title>E-health applications and services for patient empowerment: directions for best practices in The Netherlands</article-title>
        <source>Telemed J E Health</source>  
        <year>2010</year>  
        <month>09</month>  
        <volume>16</volume>  
        <issue>7</issue>  
        <fpage>787</fpage>  
        <lpage>91</lpage>  
        <pub-id pub-id-type="doi">10.1089/tmj.2009.0156</pub-id>
        <pub-id pub-id-type="medline">20815745</pub-id></nlm-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>McKee</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Karanikolos</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Belcher</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Stuckler</surname>
            <given-names>D</given-names>
          </name>
        </person-group>
        <article-title>Austerity: a failed experiment on the people of Europe</article-title>
        <source>Clin Med (Lond)</source>  
        <year>2012</year>  
        <month>08</month>  
        <volume>12</volume>  
        <issue>4</issue>  
        <fpage>346</fpage>  
        <lpage>50</lpage>  
        <pub-id pub-id-type="medline">22930881</pub-id></nlm-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ancker</surname>
            <given-names>JS</given-names>
          </name>
          <name name-style="western">
            <surname>Brenner</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Richardson</surname>
            <given-names>JE</given-names>
          </name>
          <name name-style="western">
            <surname>Silver</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Kaushal</surname>
            <given-names>R</given-names>
          </name>
        </person-group>
        <article-title>Trends in public perceptions of electronic health records during early years of meaningful use</article-title>
        <source>Am J Manag Care</source>  
        <year>2015</year>  
        <month>08</month>  
        <volume>21</volume>  
        <issue>8</issue>  
        <fpage>e487</fpage>  
        <lpage>93</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/26625503"/>
        </comment>  
        <pub-id pub-id-type="medline">26625503</pub-id>
        <pub-id pub-id-type="pmcid">PMC5474313</pub-id></nlm-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ancker</surname>
            <given-names>JS</given-names>
          </name>
          <name name-style="western">
            <surname>Osorio</surname>
            <given-names>SN</given-names>
          </name>
          <name name-style="western">
            <surname>Cheriff</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Cole</surname>
            <given-names>CL</given-names>
          </name>
          <name name-style="western">
            <surname>Silver</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Kaushal</surname>
            <given-names>R</given-names>
          </name>
        </person-group>
        <article-title>Patient activation and use of an electronic patient portal</article-title>
        <source>Inform Health Soc Care</source>  
        <year>2015</year>  
        <month>04</month>  
        <volume>40</volume>  
        <issue>3</issue>  
        <fpage>254</fpage>  
        <lpage>66</lpage>  
        <pub-id pub-id-type="doi">10.3109/17538157.2014.908200</pub-id>
        <pub-id pub-id-type="medline">24786648</pub-id></nlm-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Smith</surname>
            <given-names>SG</given-names>
          </name>
          <name name-style="western">
            <surname>O'Conor</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Aitken</surname>
            <given-names>W</given-names>
          </name>
          <name name-style="western">
            <surname>Curtis</surname>
            <given-names>LM</given-names>
          </name>
          <name name-style="western">
            <surname>Wolf</surname>
            <given-names>MS</given-names>
          </name>
          <name name-style="western">
            <surname>Goel</surname>
            <given-names>MS</given-names>
          </name>
        </person-group>
        <article-title>Disparities in registration and use of an online patient portal among older adults: findings from the LitCog cohort</article-title>
        <source>J Am Med Inform Assoc</source>  
        <year>2015</year>  
        <month>07</month>  
        <volume>22</volume>  
        <issue>4</issue>  
        <fpage>888</fpage>  
        <lpage>95</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://jamia.oxfordjournals.org/cgi/pmidlookup?view=long&amp;pmid=25914099"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1093/jamia/ocv025</pub-id>
        <pub-id pub-id-type="medline">25914099</pub-id>
        <pub-id pub-id-type="pii">ocv025</pub-id></nlm-citation>
      </ref>
      <ref id="ref13">
        <label>13</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Zhang</surname>
            <given-names>X</given-names>
          </name>
          <name name-style="western">
            <surname>Yu</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Yan</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Ton AM Spil</surname>
            <given-names>I</given-names>
          </name>
        </person-group>
        <article-title>Using diffusion of innovation theory to understand the factors impacting patient acceptance and use of consumer e-health innovations: a case study in a primary care clinic</article-title>
        <source>BMC Health Serv Res</source>  
        <year>2015</year>  
        <month>02</month>  
        <day>21</day>  
        <volume>15</volume>  
        <fpage>71</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-015-0726-2"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1186/s12913-015-0726-2</pub-id>
        <pub-id pub-id-type="medline">25885110</pub-id>
        <pub-id pub-id-type="pii">10.1186/s12913-015-0726-2</pub-id>
        <pub-id pub-id-type="pmcid">PMC4391079</pub-id></nlm-citation>
      </ref>
      <ref id="ref14">
        <label>14</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Gheorghiu</surname>
            <given-names>B</given-names>
          </name>
          <name name-style="western">
            <surname>Hagens</surname>
            <given-names>S</given-names>
          </name>
        </person-group>
        <article-title>Use and maturity of electronic patient portals</article-title>
        <source>Stud Health Technol Inform</source>  
        <year>2017</year>  
        <volume>234</volume>  
        <fpage>136</fpage>  
        <lpage>41</lpage>  
        <pub-id pub-id-type="medline">28186030</pub-id></nlm-citation>
      </ref>
      <ref id="ref15">
        <label>15</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Andreassen</surname>
            <given-names>HK</given-names>
          </name>
          <name name-style="western">
            <surname>Bujnowska-Fedak</surname>
            <given-names>MM</given-names>
          </name>
          <name name-style="western">
            <surname>Chronaki</surname>
            <given-names>CE</given-names>
          </name>
          <name name-style="western">
            <surname>Dumitru</surname>
            <given-names>RC</given-names>
          </name>
          <name name-style="western">
            <surname>Pudule</surname>
            <given-names>I</given-names>
          </name>
          <name name-style="western">
            <surname>Santana</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Voss</surname>
            <given-names>H</given-names>
          </name>
          <name name-style="western">
            <surname>Wynn</surname>
            <given-names>R</given-names>
          </name>
        </person-group>
        <article-title>European citizens' use of E-health services: a study of seven countries</article-title>
        <source>BMC Public Health</source>  
        <year>2007</year>  
        <volume>7</volume>  
        <fpage>53</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://www.biomedcentral.com/1471-2458/7/53"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1186/1471-2458-7-53</pub-id>
        <pub-id pub-id-type="medline">17425798</pub-id>
        <pub-id pub-id-type="pii">1471-2458-7-53</pub-id>
        <pub-id pub-id-type="pmcid">PMC1855923</pub-id></nlm-citation>
      </ref>
      <ref id="ref16">
        <label>16</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Weingart</surname>
            <given-names>SN</given-names>
          </name>
          <name name-style="western">
            <surname>Rind</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Tofias</surname>
            <given-names>Z</given-names>
          </name>
          <name name-style="western">
            <surname>Sands</surname>
            <given-names>DZ</given-names>
          </name>
        </person-group>
        <article-title>Who uses the patient internet portal? The PatientSite experience</article-title>
        <source>J Am Med Inform Assoc</source>  
        <year>2006</year>  
        <month>01</month>  
        <volume>13</volume>  
        <issue>1</issue>  
        <fpage>91</fpage>  
        <lpage>5</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/16221943"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1197/jamia.M1833</pub-id>
        <pub-id pub-id-type="medline">16221943</pub-id>
        <pub-id pub-id-type="pii">M1833</pub-id>
        <pub-id pub-id-type="pmcid">PMC1380201</pub-id></nlm-citation>
      </ref>
      <ref id="ref17">
        <label>17</label>
        <nlm-citation citation-type="book">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Daim</surname>
            <given-names>TU</given-names>
          </name>
          <name name-style="western">
            <surname>Behkami</surname>
            <given-names>NA</given-names>
          </name>
          <name name-style="western">
            <surname>Basoglu</surname>
            <given-names>N</given-names>
          </name>
          <name name-style="western">
            <surname>Kök</surname>
            <given-names>OM</given-names>
          </name>
          <name name-style="western">
            <surname>Hogaboam</surname>
            <given-names>L</given-names>
          </name>
        </person-group>
        <source>Healthcare Technology Innovation Adoption: Electronic Health Records and Other Emerging Health Information Technology Innovations</source>  
        <year>2016</year>  
        <publisher-loc>New York</publisher-loc>
        <publisher-name>Springer</publisher-name></nlm-citation>
      </ref>
      <ref id="ref18">
        <label>18</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Chang</surname>
            <given-names>I</given-names>
          </name>
          <name name-style="western">
            <surname>Hwang</surname>
            <given-names>H</given-names>
          </name>
          <name name-style="western">
            <surname>Hung</surname>
            <given-names>W</given-names>
          </name>
          <name name-style="western">
            <surname>Li</surname>
            <given-names>Y</given-names>
          </name>
        </person-group>
        <article-title>Physicians' acceptance of pharmacokinetics-based clinical decision support systems</article-title>
        <source>Expert Syst Appl</source>  
        <year>2007</year>  
        <month>8</month>  
        <volume>33</volume>  
        <issue>2</issue>  
        <fpage>296</fpage>  
        <lpage>303</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.eswa.2006.05.001</pub-id></nlm-citation>
      </ref>
      <ref id="ref19">
        <label>19</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Vanneste</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Vermeulen</surname>
            <given-names>B</given-names>
          </name>
          <name name-style="western">
            <surname>Declercq</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <article-title>Healthcare professionals' acceptance of BelRAI, a web-based system enabling person-centred recording and data sharing across care settings with interRAI instruments: a UTAUT analysis</article-title>
        <source>BMC Med Inform Decis Mak</source>  
        <year>2013</year>  
        <month>11</month>  
        <day>27</day>  
        <volume>13</volume>  
        <fpage>129</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcmedinformdecismak.biomedcentral.com/articles/10.1186/1472-6947-13-129"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1186/1472-6947-13-129</pub-id>
        <pub-id pub-id-type="medline">24279650</pub-id>
        <pub-id pub-id-type="pii">1472-6947-13-129</pub-id>
        <pub-id pub-id-type="pmcid">PMC4222843</pub-id></nlm-citation>
      </ref>
      <ref id="ref20">
        <label>20</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Dünnebeil</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Sunyaev</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Blohm</surname>
            <given-names>I</given-names>
          </name>
          <name name-style="western">
            <surname>Leimeister</surname>
            <given-names>JM</given-names>
          </name>
          <name name-style="western">
            <surname>Krcmar</surname>
            <given-names>H</given-names>
          </name>
        </person-group>
        <article-title>Determinants of physicians' technology acceptance for e-health in ambulatory care</article-title>
        <source>Int J Med Inform</source>  
        <year>2012</year>  
        <month>11</month>  
        <volume>81</volume>  
        <issue>11</issue>  
        <fpage>746</fpage>  
        <lpage>60</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.ijmedinf.2012.02.002</pub-id>
        <pub-id pub-id-type="medline">22397989</pub-id>
        <pub-id pub-id-type="pii">S1386-5056(12)00034-2</pub-id></nlm-citation>
      </ref>
      <ref id="ref21">
        <label>21</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ketikidis</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Dimitrovski</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Lazuras</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>Bath</surname>
            <given-names>PA</given-names>
          </name>
        </person-group>
        <article-title>Acceptance of health information technology in health professionals: an application of the revised technology acceptance model</article-title>
        <source>Health Informatics J</source>  
        <year>2012</year>  
        <month>06</month>  
        <volume>18</volume>  
        <issue>2</issue>  
        <fpage>124</fpage>  
        <lpage>34</lpage>  
        <pub-id pub-id-type="doi">10.1177/1460458211435425</pub-id>
        <pub-id pub-id-type="medline">22733680</pub-id>
        <pub-id pub-id-type="pii">18/2/124</pub-id></nlm-citation>
      </ref>
      <ref id="ref22">
        <label>22</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Hoque</surname>
            <given-names>MR</given-names>
          </name>
          <name name-style="western">
            <surname>Bao</surname>
            <given-names>YK</given-names>
          </name>
          <name name-style="western">
            <surname>Sorwar</surname>
            <given-names>G</given-names>
          </name>
        </person-group>
        <article-title>Investigating factors influencing the adoption of e-Health in developing countries: a patient's perspective</article-title>
        <source>Inform Health Soc Care</source>  
        <year>2017</year>  
        <month>01</month>  
        <volume>42</volume>  
        <issue>1</issue>  
        <fpage>1</fpage>  
        <lpage>17</lpage>  
        <pub-id pub-id-type="doi">10.3109/17538157.2015.1075541</pub-id>
        <pub-id pub-id-type="medline">26865037</pub-id></nlm-citation>
      </ref>
      <ref id="ref23">
        <label>23</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Kim</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Park</surname>
            <given-names>H</given-names>
          </name>
        </person-group>
        <article-title>Development of a health information technology acceptance model using consumers' health behavior intention</article-title>
        <source>J Med Internet Res</source>  
        <year>2012</year>  
        <month>10</month>  
        <volume>14</volume>  
        <issue>5</issue>  
        <fpage>e133</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://www.jmir.org/2012/5/e133/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.2143</pub-id>
        <pub-id pub-id-type="medline">23026508</pub-id>
        <pub-id pub-id-type="pii">v14i5e133</pub-id>
        <pub-id pub-id-type="pmcid">PMC3510715</pub-id></nlm-citation>
      </ref>
      <ref id="ref24">
        <label>24</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Lemire</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Paré</surname>
            <given-names>G</given-names>
          </name>
          <name name-style="western">
            <surname>Sicotte</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Harvey</surname>
            <given-names>C</given-names>
          </name>
        </person-group>
        <article-title>Determinants of internet use as a preferred source of information on personal health</article-title>
        <source>Int J Med Inform</source>  
        <year>2008</year>  
        <month>11</month>  
        <volume>77</volume>  
        <issue>11</issue>  
        <fpage>723</fpage>  
        <lpage>34</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.ijmedinf.2008.03.002</pub-id>
        <pub-id pub-id-type="medline">18434246</pub-id>
        <pub-id pub-id-type="pii">S1386-5056(08)00039-7</pub-id></nlm-citation>
      </ref>
      <ref id="ref25">
        <label>25</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Wilson</surname>
            <given-names>EV</given-names>
          </name>
          <name name-style="western">
            <surname>Lankton</surname>
            <given-names>NK</given-names>
          </name>
        </person-group>
        <article-title>Modeling patients' acceptance of provider-delivered e-health</article-title>
        <source>J Am Med Inform Assoc</source>  
        <year>2004</year>  
        <month>04</month>  
        <volume>11</volume>  
        <issue>4</issue>  
        <fpage>241</fpage>  
        <lpage>8</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/15064290"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1197/jamia.M1475</pub-id>
        <pub-id pub-id-type="medline">15064290</pub-id>
        <pub-id pub-id-type="pii">M1475</pub-id>
        <pub-id pub-id-type="pmcid">PMC436070</pub-id></nlm-citation>
      </ref>
      <ref id="ref26">
        <label>26</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Venkatesh</surname>
            <given-names>V</given-names>
          </name>
          <name name-style="western">
            <surname>Thong</surname>
            <given-names>JY</given-names>
          </name>
          <name name-style="western">
            <surname>Xu</surname>
            <given-names>X</given-names>
          </name>
        </person-group>
        <article-title>Consumer acceptance and use of information technology: extending the Unified Theory of Acceptance and Use of Technology</article-title>
        <source>MIS Q</source>  
        <year>2012</year>  
        <volume>36</volume>  
        <issue>1</issue>  
        <fpage>157</fpage>  
        <lpage>178</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="https://pdfs.semanticscholar.org/512d/d3c7e1b55786e6f918bd0411ff744bb4cf62.pdf"/>
        </comment> </nlm-citation>
      </ref>
      <ref id="ref27">
        <label>27</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Tavares</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Oliveira</surname>
            <given-names>T</given-names>
          </name>
        </person-group>
        <article-title>Electronic health record portal adoption: a cross country analysis</article-title>
        <source>BMC Med Inform Decis Mak</source>  
        <year>2017</year>  
        <month>07</month>  
        <day>05</day>  
        <volume>17</volume>  
        <issue>1</issue>  
        <fpage>97</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcmedinformdecismak.biomedcentral.com/articles/10.1186/s12911-017-0482-9"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1186/s12911-017-0482-9</pub-id>
        <pub-id pub-id-type="medline">28679423</pub-id>
        <pub-id pub-id-type="pii">10.1186/s12911-017-0482-9</pub-id>
        <pub-id pub-id-type="pmcid">PMC5499062</pub-id></nlm-citation>
      </ref>
      <ref id="ref28">
        <label>28</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Bozan</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Davey</surname>
            <given-names>B</given-names>
          </name>
          <name name-style="western">
            <surname>Parker</surname>
            <given-names>K</given-names>
          </name>
        </person-group>
        <article-title>Social influence on health IT adoption patterns of the elderly: an institutional theory based use behavior approach</article-title>
        <source>Procedia Comput Sci</source>  
        <year>2015</year>  
        <volume>63</volume>  
        <fpage>517</fpage>  
        <lpage>23</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.procs.2015.08.378</pub-id></nlm-citation>
      </ref>
      <ref id="ref29">
        <label>29</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ahadzadeh</surname>
            <given-names>AS</given-names>
          </name>
          <name name-style="western">
            <surname>Pahlevan</surname>
            <given-names>SS</given-names>
          </name>
          <name name-style="western">
            <surname>Ong</surname>
            <given-names>FS</given-names>
          </name>
          <name name-style="western">
            <surname>Khong</surname>
            <given-names>KW</given-names>
          </name>
        </person-group>
        <article-title>Integrating health belief model and technology acceptance model: an investigation of health-related internet use</article-title>
        <source>J Med Internet Res</source>  
        <year>2015</year>  
        <month>02</month>  
        <volume>17</volume>  
        <issue>2</issue>  
        <fpage>e45</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://www.jmir.org/2015/2/e45/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.3564</pub-id>
        <pub-id pub-id-type="medline">25700481</pub-id>
        <pub-id pub-id-type="pii">v17i2e45</pub-id>
        <pub-id pub-id-type="pmcid">PMC4376166</pub-id></nlm-citation>
      </ref>
      <ref id="ref30">
        <label>30</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>van de Kar</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Knottnerus</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Meertens</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Dubois</surname>
            <given-names>V</given-names>
          </name>
          <name name-style="western">
            <surname>Kok</surname>
            <given-names>G</given-names>
          </name>
        </person-group>
        <article-title>Why do patients consult the general practitioner? Determinants of their decision</article-title>
        <source>Br J Gen Pract</source>  
        <year>1992</year>  
        <month>08</month>  
        <volume>42</volume>  
        <issue>361</issue>  
        <fpage>313</fpage>  
        <lpage>6</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://bjgp.org/cgi/pmidlookup?view=long&amp;pmid=1457150"/>
        </comment>  
        <pub-id pub-id-type="medline">1457150</pub-id>
        <pub-id pub-id-type="pmcid">PMC1372171</pub-id></nlm-citation>
      </ref>
      <ref id="ref31">
        <label>31</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Nøhr</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Parv</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>Kink</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Cummings</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Almond</surname>
            <given-names>H</given-names>
          </name>
          <name name-style="western">
            <surname>Nørgaard</surname>
            <given-names>JR</given-names>
          </name>
          <name name-style="western">
            <surname>Turner</surname>
            <given-names>P</given-names>
          </name>
        </person-group>
        <article-title>Nationwide citizen access to their health data: analysing and comparing experiences in Denmark, Estonia and Australia</article-title>
        <source>BMC Health Serv Res</source>  
        <year>2017</year>  
        <month>08</month>  
        <day>07</day>  
        <volume>17</volume>  
        <issue>1</issue>  
        <fpage>534</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-017-2482-y"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1186/s12913-017-2482-y</pub-id>
        <pub-id pub-id-type="medline">28784173</pub-id>
        <pub-id pub-id-type="pii">10.1186/s12913-017-2482-y</pub-id>
        <pub-id pub-id-type="pmcid">PMC5547535</pub-id></nlm-citation>
      </ref>
      <ref id="ref32">
        <label>32</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Yi</surname>
            <given-names>MY</given-names>
          </name>
          <name name-style="western">
            <surname>Jackson</surname>
            <given-names>JD</given-names>
          </name>
          <name name-style="western">
            <surname>Park</surname>
            <given-names>JS</given-names>
          </name>
          <name name-style="western">
            <surname>Probst</surname>
            <given-names>JC</given-names>
          </name>
        </person-group>
        <article-title>Understanding information technology acceptance by individual professionals: toward an integrative view</article-title>
        <source>Inf Manag</source>  
        <year>2006</year>  
        <month>4</month>  
        <volume>43</volume>  
        <issue>3</issue>  
        <fpage>350</fpage>  
        <lpage>63</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.im.2005.08.006</pub-id></nlm-citation>
      </ref>
      <ref id="ref33">
        <label>33</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Oliveira</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Thomas</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Baptista</surname>
            <given-names>G</given-names>
          </name>
          <name name-style="western">
            <surname>Campos</surname>
            <given-names>F</given-names>
          </name>
        </person-group>
        <article-title>Mobile payment: understanding the determinants of customer adoption and intention to recommend the technology</article-title>
        <source>Comput Hum Behav</source>  
        <year>2016</year>  
        <month>08</month>  
        <volume>61</volume>  
        <fpage>404</fpage>  
        <lpage>14</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.chb.2016.03.030</pub-id></nlm-citation>
      </ref>
      <ref id="ref34">
        <label>34</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Chan</surname>
            <given-names>KM</given-names>
          </name>
          <name name-style="western">
            <surname>Pang</surname>
            <given-names>WS</given-names>
          </name>
          <name name-style="western">
            <surname>Ee</surname>
            <given-names>CH</given-names>
          </name>
          <name name-style="western">
            <surname>Ding</surname>
            <given-names>YY</given-names>
          </name>
          <name name-style="western">
            <surname>Choo</surname>
            <given-names>P</given-names>
          </name>
        </person-group>
        <article-title>Self-perception of health among elderly community dwellers in Singapore</article-title>
        <source>Ann Acad Med Singapore</source>  
        <year>1998</year>  
        <month>07</month>  
        <volume>27</volume>  
        <issue>4</issue>  
        <fpage>461</fpage>  
        <lpage>7</lpage>  
        <pub-id pub-id-type="medline">9791647</pub-id></nlm-citation>
      </ref>
      <ref id="ref35">
        <label>35</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Kaleta</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Polańska</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Dziankowska-Zaborszczyk</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Hanke</surname>
            <given-names>W</given-names>
          </name>
          <name name-style="western">
            <surname>Drygas</surname>
            <given-names>W</given-names>
          </name>
        </person-group>
        <article-title>Factors influencing self-perception of health status</article-title>
        <source>Cent Eur J Public Health</source>  
        <year>2009</year>  
        <month>09</month>  
        <volume>17</volume>  
        <issue>3</issue>  
        <fpage>122</fpage>  
        <lpage>7</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://apps.szu.cz/svi/cejph/archiv/2009-3-02-full.pdf"/>
        </comment>  
        <pub-id pub-id-type="medline">20020600</pub-id></nlm-citation>
      </ref>
      <ref id="ref36">
        <label>36</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Moore</surname>
            <given-names>GC</given-names>
          </name>
          <name name-style="western">
            <surname>Benbasat</surname>
            <given-names>I</given-names>
          </name>
        </person-group>
        <article-title>Development of an instrument to measure the perceptions of adopting an information technology innovation</article-title>
        <source>Inf Syst Res</source>  
        <year>1991</year>  
        <month>09</month>  
        <volume>2</volume>  
        <issue>3</issue>  
        <fpage>192</fpage>  
        <lpage>222</lpage>  
        <pub-id pub-id-type="doi">10.1287/isre.2.3.192</pub-id></nlm-citation>
      </ref>
      <ref id="ref37">
        <label>37</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Lee</surname>
            <given-names>CJ</given-names>
          </name>
          <name name-style="western">
            <surname>Gray</surname>
            <given-names>SW</given-names>
          </name>
          <name name-style="western">
            <surname>Lewis</surname>
            <given-names>N</given-names>
          </name>
        </person-group>
        <article-title>Internet use leads cancer patients to be active health care consumers</article-title>
        <source>Patient Educ Couns</source>  
        <year>2010</year>  
        <month>12</month>  
        <volume>81 Suppl</volume>  
        <fpage>S63</fpage>  
        <lpage>9</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/20889279"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1016/j.pec.2010.09.004</pub-id>
        <pub-id pub-id-type="medline">20889279</pub-id>
        <pub-id pub-id-type="pii">S0738-3991(10)00552-5</pub-id>
        <pub-id pub-id-type="pmcid">PMC4209608</pub-id></nlm-citation>
      </ref>
      <ref id="ref38">
        <label>38</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Or</surname>
            <given-names>CK</given-names>
          </name>
          <name name-style="western">
            <surname>Karsh</surname>
            <given-names>BT</given-names>
          </name>
        </person-group>
        <article-title>A systematic review of patient acceptance of consumer health information technology</article-title>
        <source>J Am Med Inform Assoc</source>  
        <year>2009</year>  
        <month>07</month>  
        <volume>16</volume>  
        <issue>4</issue>  
        <fpage>550</fpage>  
        <lpage>60</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://jamia.oxfordjournals.org/cgi/pmidlookup?view=long&amp;pmid=19390112"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1197/jamia.M2888</pub-id>
        <pub-id pub-id-type="medline">19390112</pub-id>
        <pub-id pub-id-type="pii">M2888</pub-id>
        <pub-id pub-id-type="pmcid">PMC2705259</pub-id></nlm-citation>
      </ref>
      <ref id="ref39">
        <label>39</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Venkatesh</surname>
            <given-names>V</given-names>
          </name>
          <name name-style="western">
            <surname>Morris</surname>
            <given-names>MG</given-names>
          </name>
          <name name-style="western">
            <surname>Davis</surname>
            <given-names>GB</given-names>
          </name>
          <name name-style="western">
            <surname>Davis</surname>
            <given-names>FD</given-names>
          </name>
        </person-group>
        <article-title>User acceptance of information technology: toward a unified view</article-title>
        <source>MIS Q</source>  
        <year>2003</year>  
        <volume>27</volume>  
        <issue>3</issue>  
        <fpage>157</fpage>  
        <lpage>78</lpage>  
        <pub-id pub-id-type="doi">10.2307/30036540</pub-id></nlm-citation>
      </ref>
      <ref id="ref40">
        <label>40</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Fisher</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Clayton</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>Who gives a tweet: assessing patients' interest in the use of social media for health care</article-title>
        <source>Worldviews Evid Based Nurs</source>  
        <year>2012</year>  
        <month>04</month>  
        <volume>9</volume>  
        <issue>2</issue>  
        <fpage>100</fpage>  
        <lpage>8</lpage>  
        <pub-id pub-id-type="doi">10.1111/j.1741-6787.2012.00243.x</pub-id>
        <pub-id pub-id-type="medline">22432730</pub-id></nlm-citation>
      </ref>
      <ref id="ref41">
        <label>41</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Thackeray</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Crookston</surname>
            <given-names>BT</given-names>
          </name>
          <name name-style="western">
            <surname>West</surname>
            <given-names>JH</given-names>
          </name>
        </person-group>
        <article-title>Correlates of health-related social media use among adults</article-title>
        <source>J Med Internet Res</source>  
        <year>2013</year>  
        <month>01</month>  
        <day>30</day>  
        <volume>15</volume>  
        <issue>1</issue>  
        <fpage>e21</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://www.jmir.org/2013/1/e21/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.2297</pub-id>
        <pub-id pub-id-type="medline">23367505</pub-id>
        <pub-id pub-id-type="pii">v15i1e21</pub-id>
        <pub-id pub-id-type="pmcid">PMC3636287</pub-id></nlm-citation>
      </ref>
      <ref id="ref42">
        <label>42</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Keselman</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Logan</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Smith</surname>
            <given-names>CA</given-names>
          </name>
          <name name-style="western">
            <surname>Leroy</surname>
            <given-names>G</given-names>
          </name>
          <name name-style="western">
            <surname>Zeng-Treitler</surname>
            <given-names>Q</given-names>
          </name>
        </person-group>
        <article-title>Developing informatics tools and strategies for consumer-centered health communication</article-title>
        <source>J Am Med Inform Assoc</source>  
        <year>2008</year>  
        <month>07</month>  
        <volume>15</volume>  
        <issue>4</issue>  
        <fpage>473</fpage>  
        <lpage>83</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/18436895"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1197/jamia.M2744</pub-id>
        <pub-id pub-id-type="medline">18436895</pub-id>
        <pub-id pub-id-type="pii">M2744</pub-id>
        <pub-id pub-id-type="pmcid">PMC2442255</pub-id></nlm-citation>
      </ref>
      <ref id="ref43">
        <label>43</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Peek</surname>
            <given-names>ST</given-names>
          </name>
          <name name-style="western">
            <surname>Wouters</surname>
            <given-names>EJ</given-names>
          </name>
          <name name-style="western">
            <surname>van Hoof</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Luijkx</surname>
            <given-names>KG</given-names>
          </name>
          <name name-style="western">
            <surname>Boeije</surname>
            <given-names>HR</given-names>
          </name>
          <name name-style="western">
            <surname>Vrijhoef</surname>
            <given-names>HJ</given-names>
          </name>
        </person-group>
        <article-title>Factors influencing acceptance of technology for aging in place: a systematic review</article-title>
        <source>Int J Med Inform</source>  
        <year>2014</year>  
        <month>04</month>  
        <volume>83</volume>  
        <issue>4</issue>  
        <fpage>235</fpage>  
        <lpage>48</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.ijmedinf.2014.01.004</pub-id></nlm-citation>
      </ref>
      <ref id="ref44">
        <label>44</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Yuan</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Ma</surname>
            <given-names>W</given-names>
          </name>
          <name name-style="western">
            <surname>Kanthawala</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Peng</surname>
            <given-names>W</given-names>
          </name>
        </person-group>
        <article-title>Keep using my health apps: discover users' perception of health and fitness apps with the UTAUT2 model</article-title>
        <source>Telemed J E Health</source>  
        <year>2015</year>  
        <month>09</month>  
        <volume>21</volume>  
        <issue>9</issue>  
        <fpage>735</fpage>  
        <lpage>41</lpage>  
        <pub-id pub-id-type="doi">10.1089/tmj.2014.0148</pub-id>
        <pub-id pub-id-type="medline">25919238</pub-id></nlm-citation>
      </ref>
      <ref id="ref45">
        <label>45</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Menec</surname>
            <given-names>VH</given-names>
          </name>
          <name name-style="western">
            <surname>Chipperfield</surname>
            <given-names>JG</given-names>
          </name>
          <name name-style="western">
            <surname>Perry</surname>
            <given-names>RP</given-names>
          </name>
        </person-group>
        <article-title>Self-perceptions of health: a prospective analysis of mortality, control, and health</article-title>
        <source>J Gerontol B Psychol Sci Soc Sci</source>  
        <year>1999</year>  
        <month>03</month>  
        <volume>54</volume>  
        <issue>2</issue>  
        <fpage>85</fpage>  
        <lpage>93</lpage>  
        <pub-id pub-id-type="medline">10097770</pub-id></nlm-citation>
      </ref>
      <ref id="ref46">
        <label>46</label>
        <nlm-citation citation-type="book">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Baumgartner</surname>
            <given-names>H</given-names>
          </name>
        </person-group>
        <source>The Handbook of Marketing Research: Uses, Misuses, and Future Advances</source>  
        <year>2006</year>  
        <publisher-loc>Thousand Oaks, California</publisher-loc>
        <publisher-name>SAGE Publications, Inc</publisher-name></nlm-citation>
      </ref>
      <ref id="ref47">
        <label>47</label>
        <nlm-citation citation-type="book">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Rogers</surname>
            <given-names>EM</given-names>
          </name>
        </person-group>
        <source>Diffusion of Innovations, 5th ed</source>  
        <year>2003</year>  
        <publisher-loc>New York</publisher-loc>
        <publisher-name>The Free Press/ Simon &amp; Schuster, Inc</publisher-name></nlm-citation>
      </ref>
      <ref id="ref48">
        <label>48</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Miltgen</surname>
            <given-names>CL</given-names>
          </name>
          <name name-style="western">
            <surname>Popovič</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Oliveira</surname>
            <given-names>T</given-names>
          </name>
        </person-group>
        <article-title>Determinants of end-user acceptance of biometrics: integrating the "Big 3" of technology acceptance with privacy context</article-title>
        <source>Decision Support Systems</source>  
        <year>2013</year>  
        <month>12</month>  
        <volume>56</volume>  
        <fpage>103</fpage>  
        <lpage>14</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.dss.2013.05.010</pub-id></nlm-citation>
      </ref>
      <ref id="ref49">
        <label>49</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Brislin</surname>
            <given-names>RW</given-names>
          </name>
        </person-group>
        <article-title>Back-translation for cross-cultural research</article-title>
        <source>J Cross Cult Psychol</source>  
        <year>1970</year>  
        <month>09</month>  
        <day>01</day>  
        <volume>1</volume>  
        <issue>3</issue>  
        <fpage>185</fpage>  
        <lpage>216</lpage>  
        <pub-id pub-id-type="doi">10.1177/135910457000100301</pub-id></nlm-citation>
      </ref>
      <ref id="ref50">
        <label>50</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Gao</surname>
            <given-names>SJ</given-names>
          </name>
          <name name-style="western">
            <surname>Hui</surname>
            <given-names>SL</given-names>
          </name>
          <name name-style="western">
            <surname>Hall</surname>
            <given-names>KS</given-names>
          </name>
          <name name-style="western">
            <surname>Hendrie</surname>
            <given-names>HC</given-names>
          </name>
        </person-group>
        <article-title>Estimating disease prevalence from two-phase surveys with non-response at the second phase</article-title>
        <source>Stat Med</source>  
        <year>2000</year>  
        <month>08</month>  
        <day>30</day>  
        <volume>19</volume>  
        <issue>16</issue>  
        <fpage>2101</fpage>  
        <lpage>14</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/10931514"/>
        </comment>  
        <pub-id pub-id-type="medline">10931514</pub-id>
        <pub-id pub-id-type="pii">10.1002/1097-0258(20000830)19:16&lt;2101::AID-SIM523&gt;3.0.CO;2-G</pub-id>
        <pub-id pub-id-type="pmcid">PMC2837370</pub-id></nlm-citation>
      </ref>
      <ref id="ref51">
        <label>51</label>
        <nlm-citation citation-type="web">
        <source>Anacom</source>  
        <year>2016</year>  
        <access-date>2017-05-05</access-date>
        <publisher-name>O Sector das Comunicações '16. Edited by Comunicações ANd</publisher-name>
        <comment>The Communications Sector 2016 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="https://www.anacom.pt/render.jsp?contentId=1411094&amp;languageId=1">https://www.anacom.pt/render.jsp?contentId=1411094&amp;languageId=1</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6yvdbi6Wj"/></comment> </nlm-citation>
      </ref>
      <ref id="ref52">
        <label>52</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Vicente</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Reis</surname>
            <given-names>E</given-names>
          </name>
        </person-group>
        <article-title>Telephone surveys using mobile phones: an analysis of response rates, survey procedures and respondents' characteristics</article-title>
        <source>Aust J Mark Soc Res</source>  
        <year>2009</year>  
        <volume>17</volume>  
        <issue>2</issue>  
        <fpage>49</fpage>  
        <lpage>56</lpage> </nlm-citation>
      </ref>
      <ref id="ref53">
        <label>53</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Aanerud</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Braut</surname>
            <given-names>H</given-names>
          </name>
          <name name-style="western">
            <surname>Wentzel-Larsen</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Eagan</surname>
            <given-names>TM</given-names>
          </name>
          <name name-style="western">
            <surname>Bakke</surname>
            <given-names>PS</given-names>
          </name>
        </person-group>
        <article-title>Non-response in telephone surveys of COPD patients does not introduce bias</article-title>
        <source>J Telemed Telecare</source>  
        <year>2013</year>  
        <month>01</month>  
        <volume>19</volume>  
        <issue>1</issue>  
        <fpage>40</fpage>  
        <lpage>4</lpage>  
        <pub-id pub-id-type="doi">10.1177/1357633X12474960</pub-id>
        <pub-id pub-id-type="medline">23449960</pub-id>
        <pub-id pub-id-type="pii">1357633X12474960</pub-id></nlm-citation>
      </ref>
      <ref id="ref54">
        <label>54</label>
        <nlm-citation citation-type="book">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Hair</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Hult</surname>
            <given-names>GT</given-names>
          </name>
          <name name-style="western">
            <surname>Ringle</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Sarstedt</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <source>A Primer on Partial Least Squares Structural Equation Modeling (PLS-SEM), Second edition</source>  
        <year>2017</year>  
        <publisher-loc>Thousand Oaks</publisher-loc>
        <publisher-name>SAGE Publications, Inc</publisher-name></nlm-citation>
      </ref>
      <ref id="ref55">
        <label>55</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Hair</surname>
            <given-names>JF</given-names>
          </name>
          <name name-style="western">
            <surname>Sarstedt</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Ringle</surname>
            <given-names>CM</given-names>
          </name>
          <name name-style="western">
            <surname>Mena</surname>
            <given-names>JA</given-names>
          </name>
        </person-group>
        <article-title>An assessment of the use of partial least squares structural equation modeling in marketing research</article-title>
        <source>J Acad Mark Sci</source>  
        <year>2012</year>  
        <volume>40</volume>  
        <issue>3</issue>  
        <fpage>414</fpage>  
        <lpage>33</lpage>  
        <pub-id pub-id-type="doi">10.1007/s11747-011-0261-6</pub-id></nlm-citation>
      </ref>
      <ref id="ref56">
        <label>56</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ringle</surname>
            <given-names>CM</given-names>
          </name>
          <name name-style="western">
            <surname>Sarstedt</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Straub</surname>
            <given-names>DW</given-names>
          </name>
        </person-group>
        <article-title>A critical look at the use of PLS-SEM in MIS Quarterly</article-title>
        <source>MIS Q</source>  
        <year>2012</year>  
        <volume>36</volume>  
        <issue>1</issue>  
        <fpage>3</fpage>  
        <lpage>14</lpage>  
        <pub-id pub-id-type="doi">10.1108/IMR-04-2014-0148</pub-id></nlm-citation>
      </ref>
      <ref id="ref57">
        <label>57</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ringle</surname>
            <given-names>CM</given-names>
          </name>
          <name name-style="western">
            <surname>Wende</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Becker</surname>
            <given-names>JM</given-names>
          </name>
        </person-group>
        <source>Smartpls</source>  
        <access-date>2018-04-24</access-date>
        <comment>SmartPLS 3 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="https://www.smartpls.com/downloads">https://www.smartpls.com/downloads</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6yvcS6KNb"/></comment> </nlm-citation>
      </ref>
      <ref id="ref58">
        <label>58</label>
        <nlm-citation citation-type="web">
        <source>Censo.ine</source>  
        <comment>Censos 2011 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://censos.ine.pt/xportal/xmain?xpid=CENSOS&amp;xpgid=censos_quadros_populacao">http://censos.ine.pt/xportal/xmain?xpid=CENSOS&amp;xpgid=censos_quadros_populacao</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6yvch9RVO"/></comment> </nlm-citation>
      </ref>
      <ref id="ref59">
        <label>59</label>
        <nlm-citation citation-type="web">
        <source>Pordata</source>  
        <access-date>2018-04-24</access-date>
        <comment>Thousands of Statistics about Municipalities, Portugal and Europe 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="https://www.pordata.pt/en/Home">https://www.pordata.pt/en/Home</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6yvcsiqUn"/></comment> </nlm-citation>
      </ref>
      <ref id="ref60">
        <label>60</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Mateus</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Ramalho</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Oliveira</surname>
            <given-names>H</given-names>
          </name>
          <name name-style="western">
            <surname>Rodrigues</surname>
            <given-names>H</given-names>
          </name>
          <name name-style="western">
            <surname>Ferreira</surname>
            <given-names>R</given-names>
          </name>
        </person-group>
        <source>Aphp-pt</source>  
        <access-date>2018-04-24</access-date>
        <comment>Sector Privado da Saúde em Portugal 2017 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://www.aphp-pt.org/pdf/Estudo-Sector_Privado_da_Sa%C3%BAde_em_Portugal.pdf">http://www.aphp-pt.org/pdf/Estudo-Sector_Privado_da_Sa%C3%BAde_em_Portugal.pdf</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6yvc3pmLm"/></comment> </nlm-citation>
      </ref>
      <ref id="ref61">
        <label>61</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ronda</surname>
            <given-names>MC</given-names>
          </name>
          <name name-style="western">
            <surname>Dijkhorst-Oei</surname>
            <given-names>LT</given-names>
          </name>
          <name name-style="western">
            <surname>Gorter</surname>
            <given-names>KJ</given-names>
          </name>
          <name name-style="western">
            <surname>Beulens</surname>
            <given-names>JW</given-names>
          </name>
          <name name-style="western">
            <surname>Rutten</surname>
            <given-names>G</given-names>
          </name>
        </person-group>
        <article-title>Differences between diabetes patients who are interested or not in the use of a patient Web portal</article-title>
        <source>Diabetes Technol Ther</source>  
        <year>2013</year>  
        <month>07</month>  
        <volume>15</volume>  
        <issue>7</issue>  
        <fpage>556</fpage>  
        <lpage>63</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/23777369"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1089/dia.2013.0023</pub-id>
        <pub-id pub-id-type="medline">23777369</pub-id>
        <pub-id pub-id-type="pmcid">PMC3709590</pub-id></nlm-citation>
      </ref>
      <ref id="ref62">
        <label>62</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Böhm</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Schmid</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Götze</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Landwehr</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Rothgang</surname>
            <given-names>H</given-names>
          </name>
        </person-group>
        <article-title>Five types of OECD healthcare systems: empirical results of a deductive classification</article-title>
        <source>Health Policy</source>  
        <year>2013</year>  
        <month>12</month>  
        <volume>113</volume>  
        <issue>3</issue>  
        <fpage>258</fpage>  
        <lpage>69</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.healthpol.2013.09.003</pub-id>
        <pub-id pub-id-type="medline">24095274</pub-id>
        <pub-id pub-id-type="pii">S0168-8510(13)00228-5</pub-id></nlm-citation>
      </ref>
      <ref id="ref63">
        <label>63</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Jhamb</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Cavanaugh</surname>
            <given-names>KL</given-names>
          </name>
          <name name-style="western">
            <surname>Bian</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Chen</surname>
            <given-names>G</given-names>
          </name>
          <name name-style="western">
            <surname>Ikizler</surname>
            <given-names>TA</given-names>
          </name>
          <name name-style="western">
            <surname>Unruh</surname>
            <given-names>ML</given-names>
          </name>
          <name name-style="western">
            <surname>Abdel-Kader</surname>
            <given-names>K</given-names>
          </name>
        </person-group>
        <article-title>Disparities in electronic health record patient portal use in nephrology clinics</article-title>
        <source>Clin J Am Soc Nephrol</source>  
        <year>2015</year>  
        <month>11</month>  
        <day>06</day>  
        <volume>10</volume>  
        <issue>11</issue>  
        <fpage>2013</fpage>  
        <lpage>22</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://cjasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=26493242"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2215/CJN.01640215</pub-id>
        <pub-id pub-id-type="medline">26493242</pub-id>
        <pub-id pub-id-type="pii">CJN.01640215</pub-id>
        <pub-id pub-id-type="pmcid">PMC4633780</pub-id></nlm-citation>
      </ref>
      <ref id="ref64">
        <label>64</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Podsakoff</surname>
            <given-names>PM</given-names>
          </name>
          <name name-style="western">
            <surname>MacKenzie</surname>
            <given-names>SB</given-names>
          </name>
          <name name-style="western">
            <surname>Lee</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Podsakoff</surname>
            <given-names>NP</given-names>
          </name>
        </person-group>
        <article-title>Common method biases in behavioral research: a critical review of the literature and recommended remedies</article-title>
        <source>J Appl Psychol</source>  
        <year>2003</year>  
        <month>10</month>  
        <volume>88</volume>  
        <issue>5</issue>  
        <fpage>879</fpage>  
        <lpage>903</lpage>  
        <pub-id pub-id-type="doi">10.1037/0021-9010.88.5.879</pub-id>
        <pub-id pub-id-type="medline">14516251</pub-id>
        <pub-id pub-id-type="pii">2003-08045-010</pub-id></nlm-citation>
      </ref>
      <ref id="ref65">
        <label>65</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Lindell</surname>
            <given-names>MK</given-names>
          </name>
          <name name-style="western">
            <surname>Whitney</surname>
            <given-names>DJ</given-names>
          </name>
        </person-group>
        <article-title>Accounting for common method variance in cross-sectional research designs</article-title>
        <source>J Appl Psychol</source>  
        <year>2001</year>  
        <month>02</month>  
        <volume>86</volume>  
        <issue>1</issue>  
        <fpage>114</fpage>  
        <lpage>21</lpage>  
        <pub-id pub-id-type="medline">11302223</pub-id></nlm-citation>
      </ref>
      <ref id="ref66">
        <label>66</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Malhotra</surname>
            <given-names>NK</given-names>
          </name>
          <name name-style="western">
            <surname>Kim</surname>
            <given-names>SS</given-names>
          </name>
          <name name-style="western">
            <surname>Patil</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <article-title>Common method variance in IS Research: a comparison of alternative approaches and a reanalysis of past research</article-title>
        <source>Manage Sci</source>  
        <year>2006</year>  
        <month>12</month>  
        <volume>52</volume>  
        <issue>12</issue>  
        <fpage>1865</fpage>  
        <lpage>83</lpage>  
        <pub-id pub-id-type="doi">10.1287/mnsc.1060.0597</pub-id></nlm-citation>
      </ref>
      <ref id="ref67">
        <label>67</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Altman</surname>
            <given-names>DG</given-names>
          </name>
          <name name-style="western">
            <surname>Bland</surname>
            <given-names>JM</given-names>
          </name>
        </person-group>
        <article-title>Missing data</article-title>
        <source>Br Med J</source>  
        <year>2007</year>  
        <month>02</month>  
        <day>24</day>  
        <volume>334</volume>  
        <issue>7590</issue>  
        <fpage>424</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/17322261"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1136/bmj.38977.682025.2C</pub-id>
        <pub-id pub-id-type="medline">17322261</pub-id>
        <pub-id pub-id-type="pii">334/7590/424</pub-id>
        <pub-id pub-id-type="pmcid">PMC1804157</pub-id></nlm-citation>
      </ref>
      <ref id="ref68">
        <label>68</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Powney</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Williamson</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Kirkham</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Kolamunnage-Dona</surname>
            <given-names>R</given-names>
          </name>
        </person-group>
        <article-title>A review of the handling of missing longitudinal outcome data in clinical trials</article-title>
        <source>Trials</source>  
        <year>2014</year>  
        <month>06</month>  
        <day>19</day>  
        <volume>15</volume>  
        <fpage>237</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="https://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-15-237"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1186/1745-6215-15-237</pub-id>
        <pub-id pub-id-type="medline">24947664</pub-id>
        <pub-id pub-id-type="pii">1745-6215-15-237</pub-id>
        <pub-id pub-id-type="pmcid">PMC4087243</pub-id></nlm-citation>
      </ref>
      <ref id="ref69">
        <label>69</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Evans</surname>
            <given-names>SJ</given-names>
          </name>
        </person-group>
        <article-title>Good surveys guide</article-title>
        <source>Br Med J</source>  
        <year>1991</year>  
        <month>02</month>  
        <day>09</day>  
        <volume>302</volume>  
        <issue>6772</issue>  
        <fpage>302</fpage>  
        <lpage>3</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/2001503"/>
        </comment>  
        <pub-id pub-id-type="medline">2001503</pub-id>
        <pub-id pub-id-type="pmcid">PMC1669002</pub-id></nlm-citation>
      </ref>
      <ref id="ref70">
        <label>70</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Kalton</surname>
            <given-names>G</given-names>
          </name>
          <name name-style="western">
            <surname>Anderson</surname>
            <given-names>DW</given-names>
          </name>
        </person-group>
        <article-title>Sampling rare populations</article-title>
        <source>J R Stat Soc Ser A</source>  
        <year>1986</year>  
        <volume>149</volume>  
        <issue>1</issue>  
        <fpage>65</fpage>  
        <lpage>82</lpage>  
        <pub-id pub-id-type="doi">10.2307/2981886</pub-id></nlm-citation>
      </ref>
      <ref id="ref71">
        <label>71</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Picot</surname>
            <given-names>SJ</given-names>
          </name>
          <name name-style="western">
            <surname>Samonte</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Tierney</surname>
            <given-names>JA</given-names>
          </name>
          <name name-style="western">
            <surname>Connor</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Powel</surname>
            <given-names>LL</given-names>
          </name>
        </person-group>
        <article-title>Effective sampling of rare population elements: black female caregivers and noncaregivers</article-title>
        <source>Res Aging</source>  
        <year>2001</year>  
        <month>11</month>  
        <day>01</day>  
        <volume>23</volume>  
        <issue>6</issue>  
        <fpage>694</fpage>  
        <lpage>712</lpage>  
        <pub-id pub-id-type="doi">10.1177/0164027501236004</pub-id></nlm-citation>
      </ref>
      <ref id="ref72">
        <label>72</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Osborn</surname>
            <given-names>CY</given-names>
          </name>
          <name name-style="western">
            <surname>Mayberry</surname>
            <given-names>LS</given-names>
          </name>
          <name name-style="western">
            <surname>Wallston</surname>
            <given-names>KA</given-names>
          </name>
          <name name-style="western">
            <surname>Johnson</surname>
            <given-names>KB</given-names>
          </name>
          <name name-style="western">
            <surname>Elasy</surname>
            <given-names>TA</given-names>
          </name>
        </person-group>
        <article-title>Understanding patient portal use: implications for medication management</article-title>
        <source>J Med Internet Res</source>  
        <year>2013</year>  
        <month>07</month>  
        <day>03</day>  
        <volume>15</volume>  
        <issue>7</issue>  
        <fpage>e133</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:type="simple" xlink:href="http://www.jmir.org/2013/7/e133/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.2589</pub-id>
        <pub-id pub-id-type="medline">23823974</pub-id>
        <pub-id pub-id-type="pii">v15i7e133</pub-id>
        <pub-id pub-id-type="pmcid">PMC3713921</pub-id></nlm-citation>
      </ref>
      <ref id="ref73">
        <label>73</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Hair</surname>
            <given-names>JF</given-names>
          </name>
          <name name-style="western">
            <surname>Ringle</surname>
            <given-names>CM</given-names>
          </name>
          <name name-style="western">
            <surname>Sarstedt</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>PLS-SEM: indeed a silver bullet</article-title>
        <source>J Mark Theory Pract</source>  
        <year>2011</year>  
        <volume>19</volume>  
        <issue>2</issue>  
        <fpage>139</fpage>  
        <lpage>51</lpage>  
        <pub-id pub-id-type="doi">10.2753/MTP1069-6679190202</pub-id></nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
