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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
    <article-id pub-id-type="publisher-id">v19i8e285</article-id>
    <article-id pub-id-type="pmid">28768608</article-id>
    <article-id pub-id-type="doi">10.2196/jmir.8114</article-id>
    <article-categories>
      <subj-group subj-group-type="heading">
        <subject>Original Paper</subject>
      </subj-group>
      <subj-group subj-group-type="article-type">
        <subject>Original Paper</subject>
      </subj-group>
    </article-categories>
    <title-group>
      <article-title>Web-Based Medical Service: Technology Attractiveness, Medical Creditability, Information Source, and Behavior Intention</article-title>
    </title-group>
    <contrib-group>
      <contrib contrib-type="editor">
        <name>
          <surname>Eysenbach</surname>
          <given-names>Gunther</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Wu</surname>
          <given-names>Jyh-Jeng</given-names>
        </name>
      </contrib>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Sapkota</surname>
          <given-names>Binaya</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="author" id="contrib1" corresp="yes">
      <name name-style="western">
        <surname>Wang</surname>
        <given-names>Shan Huei</given-names>
      </name>
      <degrees>PhD</degrees>
      <xref rid="aff1" ref-type="aff">1</xref>
      <address>
        <institution>Department and Graduate Institute of Business Administration</institution>
        <institution>National Taiwan University</institution>
        <addr-line>9th Floor, Building I, College of Management</addr-line>
        <addr-line>No. 85, Section 4, Roosevelt Road</addr-line>
        <addr-line>Taipei,</addr-line>
        <country>Taiwan</country>
        <phone>886 2 33661058</phone>
        <fax>886 2 23625379</fax>
        <email>d98741001@ntu.edu.tw</email>
      </address>  
      <ext-link ext-link-type="orcid">http://orcid.org/0000-0001-6999-7134</ext-link></contrib>
    </contrib-group>
    <aff id="aff1">
    <sup>1</sup>
    <institution>Department and Graduate Institute of Business Administration</institution>
    <institution>National Taiwan University</institution>  
    <addr-line>Taipei</addr-line>
    <country>Taiwan</country></aff>
    <author-notes>
      <corresp>Corresponding Author: Shan Huei Wang 
      <email>d98741001@ntu.edu.tw</email></corresp>
    </author-notes>
    <pub-date pub-type="collection"><month>08</month><year>2017</year></pub-date>
    <pub-date pub-type="epub">
      <day>02</day>
      <month>08</month>
      <year>2017</year>
    </pub-date>
    <volume>19</volume>
    <issue>8</issue>
    <elocation-id>e285</elocation-id>
    <!--history from ojs - api-xml-->
    <history>
      <date date-type="received">
        <day>30</day>
        <month>5</month>
        <year>2017</year>
      </date>
      <date date-type="rev-request">
        <day>28</day>
        <month>6</month>
        <year>2017</year>
      </date>
      <date date-type="accepted">
        <day>10</day>
        <month>7</month>
        <year>2017</year>
      </date>
    </history>
    <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
    <copyright-statement>©Shan Huei Wang. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 02.08.2017.</copyright-statement>
    <copyright-year>2017</copyright-year>
    <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
      <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.</p>
    </license>  
    <self-uri xlink:href="http://www.jmir.org/2017/8/e285/" xlink:type="simple"/>
    <abstract>
      <sec sec-type="background">
        <title>Background</title>
        <p>Web-based medical service (WBMS), a cooperative relationship between medical service and Internet technology, has been called one of the most innovative services of the 21st century. However, its business promotion and implementation in the medical industry have neither been expected nor executed. Few studies have explored this phenomenon from the viewpoint of inexperienced patients.</p>
      </sec>
      <sec sec-type="objective">
        <title>Objective</title>
        <p>The primary goal of this study was to explore whether technology attractiveness, medical creditability, and diversified medical information sources could increase users’ behavior intention.</p>
      </sec>
      <sec sec-type="methods">
        <title>Methods</title>
        <p>This study explored the effectiveness of web-based medical service by using three situations to manipulate sources of medical information. A total of 150 questionnaires were collected from people who had never used WBMS before. Hierarchical regression was used to examine the mediation and moderated-mediation effects.</p>
      </sec>
      <sec sec-type="results">
        <title>Results</title>
        <p>Perceived ease of use (<italic>P</italic>=.002) and perceived usefulness (<italic>P</italic>=.001) significantly enhance behavior intentions. Medical credibility is a mediator (<italic>P</italic>=.03), but the relationship does not significantly differ under diverse manipulative information channels (<italic>P</italic>=.39).</p>
      </sec>
      <sec sec-type="conclusions">
        <title>Conclusions</title>
        <p>Medical credibility could explain the extra variation between technology attractiveness and behavior intention, but not significant under different moderating effect of medical information sources.</p>
      </sec>
    </abstract>
    <kwd-group>
      <kwd>web-based medical service</kwd>
      <kwd>technology attractiveness</kwd>
      <kwd>medical creditability</kwd>
      <kwd>information source</kwd>
      <kwd>behavior intention</kwd>
    </kwd-group></article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <p>With the increase in the aging population and rising Medicare expenditures, medical circles [<xref ref-type="bibr" rid="ref1">1</xref>-<xref ref-type="bibr" rid="ref3">3</xref>] and management practitioners are debating how people can use technology and the Internet to improve health services [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>]. Web-based medical services (WBMS) such as eHealth, mHealth, and telehealth seem feasible solutions [<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref7">7</xref>]. WBMS is considered as one of the most innovative services in medical technology in the 21<sup>st</sup>century [<xref ref-type="bibr" rid="ref8">8</xref>]; however, promoting these services is still a challenge [<xref ref-type="bibr" rid="ref5">5</xref>]. There are 3 impediments: perceived usefulness, behavior change, and medical law limitation.</p>
      <p>Most WBMS focus on patients or potential patients with chronic conditions such as hypertension and diabetes. It is difficult for patients who do not use WBMS to see their value. The goal of WBMS is “prevention is better than cure.” That means WBMS needs to take a long time to show its effectiveness before serious symptoms occur. In addition, most patients are accustomed to face-to-face clinic services. Older patients in particular do not want to communicate with health care via the Internet. Finally, medical advertisement and doctor-endorsement on public are illegal for hospitals and related institutions, which makes word of mouth and noncommercial referrals by medical workers play an important role in WBMS.</p>
      <p>A large body of literature has explored the relationship between the technology acceptance model and behavior intention in medical fields [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref9">9</xref>-<xref ref-type="bibr" rid="ref13">13</xref>]. Results showed that perceived usefulness (PU) and perceived ease of use (PEOU) have positive impact on behavior intention. Other studies have investigated these relationships from the viewpoint of physicians and nurses [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref14">14</xref>-<xref ref-type="bibr" rid="ref17">17</xref>]. Unlike other medical services, WBMS incorporates the interaction among medical workers and patients into the Web-based technology system to deliver medical services [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>]. It is a patient-centered service designed to improve access to care for patients who need long term care or who have limited mobility [<xref ref-type="bibr" rid="ref20">20</xref>], however, exploring from patient’s viewpoint is still a neglected area.</p>
      <p>Earlier studies have explored antecedent factors [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref21">21</xref>], and moderating factors which affect technology attractiveness, in terms of PU, PEOU, and behavior intention [<xref ref-type="bibr" rid="ref22">22</xref>]. Previous studies claim that medical credibility plays an important role in WBMS [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref23">23</xref>]; however, few studies explore the mediating effects of medical credibility on this relationship. In addition, under the constraints of medical law, different sources of medical information may result in different moderating effects among technology attractiveness, medical credibility and behavior intentions on WBMS [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref25">25</xref>]. The purpose of this study was, therefore, to explore the relationship among technology attractiveness, medical credibility, information source, and behavior intention on WBMS service. The objectives of this study were to (1) examine the technology attractiveness of WBMS and behavior intention from inexperienced patients’ view point, (2) examine the mediating effect of medical credibility, and (3) explore the moderated-mediation effect of different medical information sources.</p>
      <p>This study begins with a review of the literature on WBMS, technology attractiveness, medical credibility, and medical information sources. Based on the literature review, this study formulates the hypotheses, describes the methods and sample, and presents the results. Finally, the theoretical contribution, managerial implications, and future directions for research are discussed.</p>
      <sec>
        <title>Literature Review and Hypotheses</title>
        <sec>
          <title>Web-Based Medical Service Model</title>
          <p>Web-based medical service (WBMS) is defined broadly as the use of Information and Communication Technologies (ICT) to provide medical information and services, including telephone intervention, medical education, and timely medical consultations [<xref ref-type="bibr" rid="ref6">6</xref>]. It is called eHealth and mHealth (mobile health) in the Journal of Medical Internet Research (JMIR) and tele-health in other journals such as New England Journal Medicine (NEJM) and the Journal of the American Medical Association (JAMA). It is a patient-centered and online to offline service that provides patients with timely medical consultations at home and is a self-management medical service [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref26">26</xref>]. It is also a promising strategy for improving heart failure outcomes by monitoring patients remotely; therefore, physicians can intervene early if there is evidence of clinical deterioration [<xref ref-type="bibr" rid="ref27">27</xref>].</p>
          <p>The service process of WBMS is as follows: a patient participating in the service is given a set of specifically designed equipment, including a mini-personal computer or mobile phone and several devices to measure physiological indicators, which are installed at his or her home. Patients are requested to measure several physiological indicators (eg, blood pressure, blood sugar, ECG, and SPO2), and these indicators are automatically uploaded to the database of the hospital via the Internet. If some of the indicators are outside the acceptable ranges set by physicians according to each patient’s physical condition, nurses will then check relevant historical indicators and provide appropriate medical education and consultations immediately. If the patient’s condition is not improving, then an early doctor visit or emergency services may be necessary.</p>
        </sec>
        <sec>
          <title>Technology Attractiveness and Behavior Intention</title>
          <p>In this study, technology attractiveness is defined as the degree of users’ acceptance of new technology, in terms of PU and PEOU of WBMS. PU is referred as the degree to which a person believes that using a particular system would enhance his or her job performance, and PEOU is referred as the degree to which a person believes that using a particular system would be free of effort [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref9">9</xref>].</p>
          <p>A number of studies have investigated the relationship between technology attractiveness and behavior intention of medical workers [<xref ref-type="bibr" rid="ref4">4</xref>]. One stream focuses on physician’s intention [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>]; the other focuses on nurse’s intention [<xref ref-type="bibr" rid="ref14">14</xref>]. Wu et al [<xref ref-type="bibr" rid="ref17">17</xref>] find that when making a decision to accept or reject a telemedicine technology, physicians appear to be fairly pragmatic, concentrating on the technology’s usefulness rather than on its ease of use. Similarly, Ammenwerth et al [<xref ref-type="bibr" rid="ref14">14</xref>] introduced a computer-based nursing documentation system and systematically evaluated its preconditions and effects in a pretest-posttest intervention study. The results showed that the amount of nurse’s self-confidence when using computer is important before technology system implementation stage, but after implementation stage, the fit between nursing workflow and the functionality of the system were relatively more important. In sum, prior studies all support that PU and PEOU of computer and Internet access at workplace would be helpful in increasing medical workers’ behavior intention [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref17">17</xref>]. However, unlike other medical service, WBMS is a 3-sided cooperative model, including health care worker, patient, and technology. Patients’ acceptance will affect the success of WBMS in the early stages, but surveys from inexperienced patients’ viewpoints are still scarce [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref28">28</xref>]. According to the above reasons, this study proposes following hypothesis:</p>
          <disp-formula>Hypothesis 1: There is a positive relationship between technology attractiveness and potential patient behavior intention.</disp-formula>
        </sec>
        <sec>
          <title>The Mediation Effect of Medical Credibility</title>
          <p>Previous studies focused on the antecedent factors of intention behavior (see the review article by Or and Karsh [<xref ref-type="bibr" rid="ref21">21</xref>]), and moderating effects on technology attractiveness and behavior intention [<xref ref-type="bibr" rid="ref22">22</xref>]. Or et al [<xref ref-type="bibr" rid="ref29">29</xref>] summarize that technology attractiveness, subjective norm, and healthcare knowledge can predict most of the variance in patients’ acceptance of web-based self-management technology. Sun and Zhang [<xref ref-type="bibr" rid="ref22">22</xref>] find that organizational, technological, and individual factors can moderate the relationship between technology attractiveness and behavior intention; however, few studies have examined the mediating effects on this relationship [<xref ref-type="bibr" rid="ref9">9</xref>].</p>
          <p>Ajzen and Fishbein [<xref ref-type="bibr" rid="ref30">30</xref>] claim that a person who carries out a behavior intention is affected by subjective norm and attitude towards the behavior. However, attitudes do not fully mediate the relationship between technology attractiveness, in terms of PU and PEOU, on behavior intention [<xref ref-type="bibr" rid="ref9">9</xref>]. That means that more significant factors such as medical credibility can mediate this relationship. However, studies have seldom noted this relationship. Medical credibility is defined as the willingness of patients to be vulnerable to the actions of medical service based on the expectation that the medical workers will perform a particular and trusted medical treatment important to them [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>].</p>
          <p>Unlike traditional medical service, WBMS requires the simultaneous cooperation of medical workers, patients, and the web-based technology system to deliver medical services [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>]. However, most elderly patients are accustomed to face-to-face clinic services and they do not like communication over the Internet. McGrail et al [<xref ref-type="bibr" rid="ref20">20</xref>] found that older patients are more likely to see a known medical provider, and patients from the lowest socioeconomic strata were the least likely to use a virtual medical service. Hence, earning patients’ trust and strengthening the medical creditability of WBMS in the service delivery process is important.</p>
          <p>There are 2 stages in the medical delivery process of WBMS. In the first stage, patients encounter the technology and perceive its potential function, convenience, and fairness [<xref ref-type="bibr" rid="ref33">33</xref>]. After the patients have used the technology for a while, the medical workers will provide a monthly report that documents each day’s physiological indicators, medical education, and suggestions offered by nurses and physicians. In the second stage, patients will evaluate the credibility of medical reports and the whole medical service delivery process of WBMS [<xref ref-type="bibr" rid="ref28">28</xref>]. An earlier study supports that when patients have positive perception on medical credibility and trust this service, they are more willing to recommend it [<xref ref-type="bibr" rid="ref34">34</xref>]. Hence, this study argues that a successful business model of WBMS needs both patients’ confidence in the web-based technology system and their trust in medical service they contact via the Internet every day.</p>
          <disp-formula>Hypothesis 2: A medical creditability plays a mediator role between technology attractiveness and potential patient’s behavior intention.</disp-formula>
        </sec>
        <sec>
          <title>The Moderated Role of Medical Information Sources</title>
          <p>A person who engages in a particular behavior or produces an intention is affected by his or her subjective norm and attitude towards the behavior. Subjective norm is defined as the way in which individuals decide to take a behavioral intention when facing social pressure to accept the opinion, which may come from family, friends, supervisors, and colleagues [<xref ref-type="bibr" rid="ref30">30</xref>]. Fishbein and Ajzen [<xref ref-type="bibr" rid="ref18">18</xref>] point out that individual behavior, such as assessing a product or service, is subject to the amount of information the person has obtained. In addition, the key person (or information source) has an important role in an individual’s evaluation of information [<xref ref-type="bibr" rid="ref35">35</xref>]. For example, studies have found that the way in which consumers choose and evaluate information on medicines can influence their attitudes to and use of those medicines [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref25">25</xref>]. Peterson et al [<xref ref-type="bibr" rid="ref25">25</xref>] interviewed people who researched medicines online. Some of those participants preferred information provided by pharmaceutical companies, others preferred information from governments, organizations, and medical schools, and still others preferred word of mouth from other consumers who had already taken that medication. Koufopoulos et al [<xref ref-type="bibr" rid="ref24">24</xref>] found that communities can have positive treatment outcomes, particularly for the management of chronic illness. Some researchers have concluded that patients trust physicians more than they trust online medical information, which they consult before talking with their physicians [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>]. Accordingly, this study proposes that different information sources have different effects on the relationship among technology attractiveness, patients’ trust in medical credibility, and behavior intention. This study investigates whether information sources have a moderated-mediation effect by word of mouth of friends, recommendations from medical workers, and advertisements from a nonofficial medical company.</p>
          <disp-formula>Hypothesis 3: Medical information sources have a moderated-mediation role between technology attractiveness and potential patient’s behavior intention.</disp-formula>
        </sec>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Conceptual Framework</title>
        <p>In order to explore (1) technology attractiveness of WBMS from potential patients’ viewpoint, (2) the mediate effects of medical credibility, and (3) the moderated-mediation effect of medical information sources, the framework of this study was constructed as shown in <xref ref-type="fig" rid="figure1">Figure 1</xref>.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>The framework of this study.</p>
          </caption>
          <graphic xlink:href="jmir_v19i8e285_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Sample Selection and Design</title>
        <p>WBMS had been carried out for several years in Taiwan, but service providers wanted to know why it is still unfamiliar to and rejected by most of the population. This study collected 213 samples from several courses in Taipei; however, unlike previous studies, the purpose of this study was to investigate whether potential patients were willing to use or recommend WBMS to other potential patients. For this reason, the target sample had to meet the following criteria: (1) the participants had not used or heard of WBMS before the investigation; (2) they, their families, and friends were at high risk for high blood pressure, diabetes, and cardiovascular diseases; and (3) they had basic computer knowledge and Internet experience. Surveys with missing data were excluded, as were participants who did not meet the 3 criteria. Only 150 questionnaires were used in this study, 98 (65.3%) of which were completed by females and 52 (34.7%) were completed by males. The participants ranged in age from 26 to 50 years (mean 35). All participants used the Internet on an average of 3 to 4 times a week.</p>
        <p>To examine the effect of different information source, participants were randomly divided into 3 groups. Group 1 (n=50) manipulated information source from friends or family, group 2 (n=50) had an information source from nonofficial medical company, and group 3 (n=50) had information from an official medical source, such as a physician. Randomization was done by a random number generator [<xref ref-type="bibr" rid="ref38">38</xref>]. In addition, all participants were asked to log into the eHealth website [<xref ref-type="bibr" rid="ref39">39</xref>] that explained how to operate the WBMS instrument and the benefits of WBMS in <xref ref-type="fig" rid="figure2">Figure 2</xref>. This study conformed to the consolidated standards of reporting trials eHealth checklist (<xref ref-type="app" rid="app1">Multimedia Appendix 1</xref>) [<xref ref-type="bibr" rid="ref40">40</xref>] and CHERRIES checklist to improve the quality of questionnaires checklist (<xref ref-type="app" rid="app2">Multimedia Appendix 2</xref>) [<xref ref-type="bibr" rid="ref41">41</xref>].</p>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>Web-based medical service.</p>
          </caption>
          <graphic xlink:href="jmir_v19i8e285_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Measures</title>
        <p>To explore the intention of potential patients when they used the different information source, this study combined experimental design and questionnaires to collect data through 3 kinds of different situations. It was not possible to find a perfectly suited questionnaire to measure our hypotheses, hence appropriate amendments mainly based on past scholars’ questionnaires were made. Furthermore, the adapted scales were originally in English, so previously established protocols of back translation were followed [<xref ref-type="bibr" rid="ref42">42</xref>] to ensure that the translated Chinese questionnaire had similar meanings. Only 2 people who were bilingual in English and Chinese were hired, with one translating the English questionnaire into Chinese and the other cross-translating the items back into English. The researchers and the bilingual persons resolved any semantic inconsistencies and made minor adjustments in word choice before the survey was implemented. This study referred to Davis [<xref ref-type="bibr" rid="ref9">9</xref>] questionnaire for testing technology attractiveness and behavior intention and followed Ajzen [<xref ref-type="bibr" rid="ref35">35</xref>] and Gefen et al’s [<xref ref-type="bibr" rid="ref19">19</xref>] questionnaires for the items of medical credibility. Participants rated all items on a 5-point Likert scale ranging from 1 (‘‘strongly disagree’’) to 5 (‘‘strongly agree’’). More details are shown in <xref ref-type="app" rid="app3">Multimedia Appendix 3</xref>.</p>
      </sec>
      <sec>
        <title>Data Analyses</title>
        <p>This study used LISREL 8.54 (Scientific Software International, Inc. Skokie, IL, USA) to assess the convergent and discriminant validity of the constructs with a confirmatory factor analysis (CFA), and adopted maximum likelihood to rotate the constructs [<xref ref-type="bibr" rid="ref43">43</xref>]. This study used multiple indexes to assess model fit: chi-square test (χ<sup>2</sup>), root mean of squared error of approximation (RMSEA), and its confidence interval, comparative fit index (CFI), incremental fit index (IFI), and goodness-of-fit index (GFI) [<xref ref-type="bibr" rid="ref44">44</xref>]. In addition, scholars pointed out that the RMSEA higher than 1.0 meant poor model fit, between 0.05 and 0.08 meant accepted range, and lower than 0.05 meant good model fit [<xref ref-type="bibr" rid="ref44">44</xref>]. CFI, GFI, and IFI were between 0 and 1, and the minimum acceptable value of CFI, GFI and IFI were 0.9 [<xref ref-type="bibr" rid="ref45">45</xref>]. This study also used SPSS version 10 (SPSS Inc, Chicago, IL, USA) statistical software to examine the hypotheses. To test Hypotheses 1 and 2, this study followed Baron and Kenny [<xref ref-type="bibr" rid="ref46">46</xref>] procedures for the partial mediation test. A total of 3 conditions were applied: (1) a significant effect of technology attractiveness on patients’ behavior intention, (2) a significant effect of technology attractiveness on medical credibility, and (3) a significant effect of medical credibility on potential patients’ intentions when model considered technology attractiveness.</p>
        <p>To test the moderated-mediation effects in the model (Hypothesis 3), this study followed 3 condition steps recommended by Muller et al [<xref ref-type="bibr" rid="ref47">47</xref>], (1) a significant effect of technology attractiveness on patients’ behavior intention, (2) a significant effect of technology attractiveness on medical credibility and a significant interaction between technology attractiveness and medical information source, and (3) a significant interaction between technology attractiveness and medical information source on potential patients’ behavior intention and a significant interaction between medical credibility and information sources.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <p><xref ref-type="table" rid="table1">Table 1</xref> shows the means, standard deviations, and correlations of all dimensions. The correlations of 4 dimensions are highly relevant to each other, hence, this study used variance inflation factor (VIF) to examine the problem. None of the VIF was larger than 0.5, which means that there is no multicollinearity problem in this study [<xref ref-type="bibr" rid="ref48">48</xref>].</p>
      <sec>
        <title>Reliability and Validity</title>
        <p>To make sure the questionnaire items reflect the true meaning of constructs, a series of reliability and validity tests were conducted. This study used CFA to examine convergent validity, and 2 items were deleted in this study. The overall model fit of the measurement model was examined from several fit indexes: chi-square test was significant (χ<sup>2</sup><sub>51</sub>=89.6, <italic>P</italic>&#60;.001), RMSEA was .07, GFI was .91, CFI was .93, adjusted goodness-of-fit (AGFI) was .857, and all indicators ensured good model fit in the measurement [<xref ref-type="bibr" rid="ref49">49</xref>-<xref ref-type="bibr" rid="ref52">52</xref>]. Furthermore, the average variance extracted [<xref ref-type="bibr" rid="ref20">20</xref>] of each construct was larger than 0.5, a good convergent validity in the measurement model [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref53">53</xref>]. Finally, Fornell and Larcker [<xref ref-type="bibr" rid="ref53">53</xref>] claimed that a good discriminant validity was evident when the Average Variance Extracted (AVE) was larger than the square root of the construct correlation (Φ2). All correlations in <xref ref-type="table" rid="table2">Table 2</xref> were significant (<italic>P</italic>&#60;.001). All together, these results provided evidences for the convergent and discriminant validity of the proposed model. In addition, the range of composite reliability [<xref ref-type="bibr" rid="ref23">23</xref>] was 0.79, indicating good internal reliability of the questionnaire items [<xref ref-type="bibr" rid="ref54">54</xref>].</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Means, standard deviations, and intercorrelations of all dimensions. All correlation values are significant.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="505"/>
            <col width="50"/>
            <col width="50"/>
            <col width="50"/>
            <col width="50"/>
            <col width="50"/>
            <col width="75"/>
            <col width="150"/>
            <thead>
              <tr valign="top">
                <td>Variables</td>
                <td>1</td>
                <td>2</td>
                <td>3</td>
                <td>4</td>
                <td>5</td>
                <td>Means</td>
                <td>Standard deviation</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Perceived usefulness</td>
                <td>1</td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td>3.91</td>
                <td>0.82</td>
              </tr>
              <tr valign="top">
                <td>Perceived ease to use</td>
                <td>.47</td>
                <td>1</td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td>3.81</td>
                <td>0.74</td>
              </tr>
              <tr valign="top">
                <td>Medical credibility</td>
                <td>.47</td>
                <td>.37</td>
                <td>1</td>
                <td><break/></td>
                <td><break/></td>
                <td>3.92</td>
                <td>0.63</td>
              </tr>
              <tr valign="top">
                <td>Willing to use</td>
                <td>.34</td>
                <td>.31</td>
                <td>.37</td>
                <td>1</td>
                <td><break/></td>
                <td>3.84</td>
                <td>0.95</td>
              </tr>
              <tr valign="top">
                <td>Recommend to other person</td>
                <td>.35</td>
                <td>.34</td>
                <td>.36</td>
                <td>.55</td>
                <td>1</td>
                <td>3.90</td>
                <td>0.74</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Confirmatory factor analysis standardized loading.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="440"/>
            <col width="175"/>
            <col width="200"/>
            <col width="150"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Variables</td>
                <td>Standardized loading<sup>a</sup></td>
                <td>Average variance extracted</td>
                <td>Composite reliability</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="2"><bold>Perceived usefulness</bold></td>
                <td><break/></td>
                <td>.5</td>
                <td>.79</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>PU1</td>
                <td>.50</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>PU2</td>
                <td>.47</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>PU3</td>
                <td>.46</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>PU4</td>
                <td>.70</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td colspan="2"><bold>Perceived ease to use</bold></td>
                <td><break/></td>
                <td>.5</td>
                <td>.79</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>PEOU1</td>
                <td>.64</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>PEOU 2</td>
                <td>.68</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>PEOU 3</td>
                <td>.93</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>PEOU4</td>
                <td>.80</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td colspan="2"><bold>Medical credibility</bold></td>
                <td><break/></td>
                <td>.5</td>
                <td>.79</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>PMP1</td>
                <td>.73</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>PMP 2</td>
                <td>.62</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>PMP 3</td>
                <td>.61</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>PMP 4</td>
                <td>.75</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table2fn1">
              <p><sup>a</sup>All standardized loading values are significant.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Hypotheses Testing</title>
        <p>This study used the recommendations of Baron and Kenny [<xref ref-type="bibr" rid="ref46">46</xref>] and Muller et al [<xref ref-type="bibr" rid="ref47">47</xref>] to examine the hypotheses. First, as reported in Model 1 of <xref ref-type="table" rid="table3">Tables 3</xref> and <xref ref-type="table" rid="table4">4</xref>, technology attractiveness were positively significantly related to potential patients’ behavior intentions, PU and PEOU were positively related to willingness to use (beta=.29, SE=0.14, <italic>P</italic>=.04; beta =.36, SE=0.11, <italic>P</italic>=.002) and to recommend to other persons (beta =.39, SE=0.12, <italic>P</italic>=.002; beta =.32, SE=0.09, <italic>P</italic>=.001), so Hypothesis 1 was supported. Second, PU and PEOU were positively significantly related to medical credibility (beta =.38, SE=0.08, <italic>P</italic>=.001; beta =.30, SE=0.06, <italic>P</italic>=.001) in Model 2. Third, after considering the technology attractiveness, medical creditability, and potential patients’ behavior intentions in Model 3, the coefficient of medical creditability was significant. Furthermore, PU and PEOU in Model 3 were significantly smaller than those in Model 1. Hence, medical credibility had partial mediating effect on technology attractiveness and potential patients’ behavior intentions, so Hypothesis 2 was supported. This study also used the Sobel test [<xref ref-type="bibr" rid="ref55">55</xref>] to examine the mediating effect. Sobel test assumed that the relationships between the dependent variable and independent variables were hypothesized to have an indirect effect due to the influence of mediating effect. More specifically, in a regression model that includes the mediator, the effect of the independent variables is reduced, and the effect of the mediator is still statistically significant. The result showed that the medical credibility played a mediation role on the relationship between technology attractiveness and willingness to use (Z=2.32, SE=0.02, <italic>P</italic>=.03; Z=1.91, SE=0.04, <italic>P</italic>=.06) and the relationship between technology attractiveness and willingness to recommend (Z=1.96, SE=0.05, <italic>P</italic>=.05; Z=2.08, SE=0.03, <italic>P</italic>=.04). Hence, the Sobel test provided a more robust examination, and Hypothesis 2 was supported. Finally, this study explored whether medical information sources played a moderated-mediation effect. The testing conditions 1 and 2 were same as above; this study only described condition 3 here. Model 3 of <xref ref-type="table" rid="table3">Tables 3</xref> and <xref ref-type="table" rid="table4">4</xref> showed that the interaction between medical credibility and medical information sources on willingness to use (beta =.01, SE=0.12, <italic>P</italic>=.39) and willingness to recommend to others (beta =.00, SE=.01, <italic>P</italic>=.39) were not significant, so Hypothesis 3 was not supported. Hence, medical information sources did not play a moderated-mediation role on technology attractiveness and potential patients’ behavior intentions when medical credibility existed.</p>
        <table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Hierarchical linear regression results for testing willing to use (mediating effect). Table entries corresponding to the predicting variables are unstandardized estimations of the fixed effects, two-tailed.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="405"/>
            <col width="200"/>
            <col width="200"/>
            <col width="160"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Variables<sup>a</sup></td>
                <td>Model 1</td>
                <td>Model 2</td>
                <td>Model 3</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td><break/></td>
                <td>Willing to use</td>
                <td>Medical credibility</td>
                <td>Willing to use</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td><break/></td>
                <td>beta (SE)</td>
                <td>beta (SE)</td>
                <td>beta (SE)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="2">Constant</td>
                <td>1.26 (0.53)</td>
                <td>1.16 (0.29)</td>
                <td>.87 (0.56)</td>
              </tr>
              <tr valign="top">
                <td colspan="2"><bold>Independent variable</bold></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Perceived usefulness</td>
                <td>.29 (0.14)</td>
                <td>.38 (0.08)</td>
                <td>.16 (0.06)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Perceived ease to use</td>
                <td>.36 (0.11)</td>
                <td>.30 (0.06)</td>
                <td>.27 (0.13)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Medical credibility</td>
                <td><break/></td>
                <td><break/></td>
                <td>.30 (0.16)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Information source x Medical credibility</td>
                <td><break/></td>
                <td><break/></td>
                <td>.01 (0.12)</td>
              </tr>
              <tr valign="top">
                <td colspan="2"><italic>r</italic><sup>2</sup></td>
                <td>.15</td>
                <td>.38</td>
                <td>.18</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table3fn1">
              <p><sup>a</sup>n=150.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <table-wrap position="float" id="table4">
          <label>Table 4</label>
          <caption>
            <p>Hierarchical linear regression results for testing recommend to others (mediating effect). Table entries corresponding to the predicting variables are unstandardized estimations of the fixed effects, two-tailed.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="405"/>
            <col width="200"/>
            <col width="200"/>
            <col width="160"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Variables<sup>a</sup></td>
                <td>Model 1</td>
                <td>Model 2</td>
                <td>Model 3</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td><break/></td>
                <td>Recommend to others</td>
                <td>Medical credibility</td>
                <td>Recommend to others</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td><break/></td>
                <td>beta (SE)</td>
                <td>beta (SE)</td>
                <td>beta (SE)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="2">Constant</td>
                <td>.99 (0.43)</td>
                <td>1.16 (0.29)</td>
                <td>.64 (0.45)</td>
              </tr>
              <tr valign="top">
                <td colspan="2"><bold>Independent variables</bold></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Perceived usefulness</td>
                <td>.39 (0.12)</td>
                <td>.38 (0.08)</td>
                <td>.28 (0.13)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Perceived ease to use</td>
                <td>.32 (0.09)</td>
                <td>.30 (0.06)</td>
                <td>.23 (0.10)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Medical credibility</td>
                <td><break/></td>
                <td><break/></td>
                <td>.39 (0.12)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Information source x Medical credibility</td>
                <td><break/></td>
                <td><break/></td>
                <td>.00 (0.01)</td>
              </tr>
              <tr valign="top">
                <td colspan="2"><italic>r</italic><sup>2</sup></td>
                <td>.24</td>
                <td>.38</td>
                <td>.28</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table4fn1">
              <p><sup>a</sup>n=150.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>The purpose of this study is to explore whether technology attractiveness, medical creditability, and different medical information sources could create different behavior intentions. The finding indicates that technology attractiveness must be significantly positive to enhance behavior intentions. In addition, medical credibility is a mediator but not significantly different under diverse manipulative information channels <italic>.</italic></p>
      </sec>
      <sec>
        <title>Comparison With Prior Work</title>
        <p>Prior studies explored technology attractiveness and behavior intention from the viewpoints of physicians and nurses. This study finds a positive relationship between technology attractiveness and potential patients’ behavior intentions. The result is completely consistent with Davis [<xref ref-type="bibr" rid="ref9">9</xref>] TAM models. This finding indicates that even though potential patients have never used WBMS before, they are willing to share information about this medical service with their friends and family members, as they perceive the technology attractiveness of WBMS.</p>
        <p>This study also finds that medical credibility plays a mediating role between technology attractiveness and patients’ behavior intentions. This finding echoes the conclusions of McGrail et al [<xref ref-type="bibr" rid="ref20">20</xref>] and Hesse et al [<xref ref-type="bibr" rid="ref23">23</xref>] that patients have more trust in the medical credibility of face-to-face clinic service than face-to-machine, meaning that medical credibility has an important role in the service delivery process of WBMS.</p>
        <p>This study also finds that attitudes do not fully mediate the relationship between technology attractiveness and behavior intention [<xref ref-type="bibr" rid="ref9">9</xref>]. This study provides additional evidence that medical credibility is an important mediator. Finally, this study finds that different sources of medical information do not significantly moderate the relationship. This finding is not consistent with previous studies that emphasize the effects of different information sources on behavior intention [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref35">35</xref>]. Possible reasons are that the dependent variables of this study are willingness to use and willingness to recommend. The target group of WBMS is patients with chronic medical conditions, such as cardiovascular disease, hypertension, and diabetes. According to social network theory, inexperienced patients may not need this service, but their friends and family may need it. It is not costly to share this information, so the information channel of WBMS may not be important for inexperienced patients after receiving the information.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>This study makes several contributions. Numerous studies have used the technology acceptance model (TAM) to explore customers’ intentions after new technology adoption, focusing on physicians’ and nurses’ intentions, but few studies have investigated the acceptance of web-based medical service by inexperienced patients. In addition, most extensive studies of TAM explore antecedent factors [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref21">21</xref>]. This study fills the research gap on mediation effect of TAM. The result shows that medical credibility is an important mediator in WBMS. Finally, this study is one of the few to explore whether differences in sources of medical information have a moderated-mediation effect on web-based medical service.</p>
        <p>This study also offers some practical suggestions for telemedicine providers and hospitals wishing to promote WBMS. Patients are accustomed to face-to-face clinic services; they do not like communication via the Internet, especially if they are elderly. This study therefore suggests that telemedicine providers not only emphasize technology attractiveness but also the medical credibility of WBMS when introducing the service to new patients. WBMS combines online and offline services, and therefore, too much emphasis on the technology side of WBMS without taking into account the contributions of medical innovation and medical support may not appeal to the general population. This study suggests that the telemedicine providers and hospitals should pay attention to the convenience of technology (online) and medical credibility (offline) and educate patients on why prevention is better than treatment and why immediate medical intervention is important. Besides, most nonofficial medical companies think they are underperforming because they lack a physician’s recommendation. This study finds that the medical information channel is not a significant variable in influencing inexperienced patients’ behavior intentions. This study suggests that telemedicine providers should rethink their promotion strategy, rather than spend a lot of money on medical advertisement and doctor-endorsement fees. Finally, most of the target groups comprise patients with chronic disease. According to social network theory, the inexperienced patients may not need this service, but their friends and family may need the service. Telemedicine providers should not underestimate the power of social networks, especially the recommendations of inexperienced patients and the general population.</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>This study uses website descriptions and experiment designs to measure the intentions of inexperienced patients; however, the pay issues and different charging mechanisms are not considered, which could be one of the reasons that make the service difficult to promote. After all, there are still differences between intention and actual use behavior. This study suggests future research should consider this potential problem. Besides, medical information sources such as government promotion or community outreach service have not been considered. Hence, this study suggests further research should consider another effect of different sources.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <app id="app1">
        <title>Multimedia Appendix 1</title>
        <p>CONSORT-EHEALTH checklist (V1.6.1).</p>
        <media xlink:href="jmir_v19i8e285_app1.pdf" xlink:title="PDF File (Adobe PDF File), 1MB"/>
      </app>
      <app id="app2">
        <title>Multimedia Appendix 2</title>
        <p>Checklist for reporting results of Internet E-Surveys (CHERRIES).</p>
        <media xlink:href="jmir_v19i8e285_app2.pdf" xlink:title="PDF File (Adobe PDF File), 39KB"/>
      </app>
      <app id="app3">
        <title>Multimedia Appendix 3</title>
        <p>Questionnaires.</p>
        <media xlink:href="jmir_v19i8e285_app3.pdf" xlink:title="PDF File (Adobe PDF File), 50KB"/>
      </app>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">AGFI</term>
          <def>
            <p>adjusted goodness-of-fit</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">AVE</term>
          <def>
            <p>Average Variance Extracted</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">CFA</term>
          <def>
            <p>confirmatory factor analysis</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">CFI</term>
          <def>
            <p>comparative fit index</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">GFI</term>
          <def>
            <p>goodness-of-fit</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">IFI</term>
          <def>
            <p>incremental fit index</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">JMIR</term>
          <def>
            <p>journal of medical Internet research</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb8">JAMA</term>
          <def>
            <p>journal of the American medical association</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb9">NEJM</term>
          <def>
            <p>New England journal medicine</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb10">PU</term>
          <def>
            <p>perceived usefulness</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb11">PEOU</term>
          <def>
            <p>perceived ease of use</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb12">RMSEA</term>
          <def>
            <p>root mean of squared error of approximation</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb13">TAM</term>
          <def>
            <p>technology acceptance model</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb14">VIF</term>
          <def>
            <p>variance inflation factor</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb15">WBMS</term>
          <def>
            <p>Web-based medical services</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Desai</surname>
            <given-names>AS</given-names>
          </name>
          <name name-style="western">
            <surname>Stevenson</surname>
            <given-names>LW</given-names>
          </name>
        </person-group>
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