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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
    <article-id pub-id-type="publisher-id">v19i5e168</article-id>
    <article-id pub-id-type="pmid">28536096</article-id>
    <article-id pub-id-type="doi">10.2196/jmir.6681</article-id>
    <article-categories>
      <subj-group subj-group-type="heading">
        <subject>Original Paper</subject>
      </subj-group>
      <subj-group subj-group-type="article-type">
        <subject>Original Paper</subject>
      </subj-group>
    </article-categories>
    <title-group>
      <article-title>Harnessing Facebook for Smoking Reduction and Cessation Interventions: Facebook User Engagement and Social Support Predict Smoking Reduction</article-title>
    </title-group>
    <contrib-group>
      <contrib contrib-type="editor">
        <name>
          <surname>Parra-Calderón</surname>
          <given-names>Carlos Luis</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Mitchell</surname>
          <given-names>Jason</given-names>
        </name>
      </contrib>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Thrul</surname>
          <given-names>Johannes</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="author" id="contrib1" corresp="yes">
      <name name-style="western">
        <surname>Kim</surname>
        <given-names>Sunny Jung</given-names>
      </name>
      <degrees>PhD</degrees>
      <xref rid="aff1" ref-type="aff">1</xref>
      <address>
        <institution>Center for Technology and Behavioral Health</institution>
        <institution>Department of Biomedical Data Science, Department of Psychiatry</institution>
        <institution>Geisel School of Medicine at Dartmouth, Dartmouth College</institution>
        <addr-line>46 Centerra Parkway Suite 301</addr-line>
        <addr-line>Lebanon, NH, 03766</addr-line>
        <country>United States</country>
        <phone>1 603 646 7041</phone>
        <fax>1 603 646 7000</fax>
        <email>sunny.j.kim@dartmouth.edu</email>
      </address>  
      <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-6405-162X</ext-link></contrib>
      <contrib contrib-type="author" id="contrib2">
        <name name-style="western">
          <surname>Marsch</surname>
          <given-names>Lisa A</given-names>
        </name>
        <degrees>PhD</degrees>
        <xref rid="aff1" ref-type="aff">1</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0001-6429-0965</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib3">
        <name name-style="western">
          <surname>Brunette</surname>
          <given-names>Mary F</given-names>
        </name>
        <degrees>MD</degrees>
        <xref rid="aff2" ref-type="aff">2</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-0713-8745</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib4">
        <name name-style="western">
          <surname>Dallery</surname>
          <given-names>Jesse</given-names>
        </name>
        <degrees>PhD</degrees>
        <xref rid="aff3" ref-type="aff">3</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-2882-1105</ext-link>
      </contrib>
    </contrib-group>
    <aff id="aff1">
    <sup>1</sup>
    <institution>Center for Technology and Behavioral Health</institution>
    <institution>Department of Biomedical Data Science, Department of Psychiatry</institution>  
    <institution>Geisel School of Medicine at Dartmouth, Dartmouth College</institution>  
    <addr-line>Lebanon, NH</addr-line>
    <country>United States</country></aff>
    <aff id="aff2">
    <sup>2</sup>
    <institution>Center for Technology and Behavioral Health</institution>
    <institution>Department of Psychiatry</institution>  
    <institution>Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock</institution>  
    <addr-line>Lebanon, NH</addr-line>
    <country>United States</country></aff>
    <aff id="aff3">
    <sup>3</sup>
    <institution>Department of Psychology</institution>
    <institution>University of Florida</institution>  
    <addr-line>Gainesville, FL</addr-line>
    <country>United States</country></aff>
    <author-notes>
      <corresp>Corresponding Author: Sunny Jung Kim 
      <email>sunny.j.kim@dartmouth.edu</email></corresp>
    </author-notes>
    <pub-date pub-type="collection"><month>05</month><year>2017</year></pub-date>
    <pub-date pub-type="epub">
      <day>23</day>
      <month>05</month>
      <year>2017</year>
    </pub-date>
    <volume>19</volume>
    <issue>5</issue>
    <elocation-id>e168</elocation-id>
    <!--history from ojs - api-xml-->
    <history>
      <date date-type="received">
        <day>22</day>
        <month>9</month>
        <year>2016</year>
      </date>
      <date date-type="rev-request">
        <day>15</day>
        <month>10</month>
        <year>2016</year>
      </date>
      <date date-type="rev-recd">
        <day>17</day>
        <month>3</month>
        <year>2017</year>
      </date>
      <date date-type="accepted">
        <day>2</day>
        <month>4</month>
        <year>2017</year>
      </date>
    </history>
    <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
    <copyright-statement>©Sunny Jung Kim, Lisa A Marsch, Mary F Brunette, Jesse Dallery. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 23.05.2017.</copyright-statement>
    <copyright-year>2017</copyright-year>
    <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/">
      <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.</p>
    </license>  
    <self-uri xlink:href="http://www.jmir.org/2017/5/e168/" xlink:type="simple"/>
    <abstract>
      <sec sec-type="background">
        <title>Background</title>
        <p>Social media technologies offer a novel opportunity for scalable health interventions that can facilitate user engagement and social support, which in turn may reinforce positive processes for behavior change.</p>
      </sec>
      <sec sec-type="objective">
        <title>Objective</title>
        <p>By using principles from health communication and social support literature, we implemented a Facebook group–based intervention that targeted smoking reduction and cessation. This study hypothesized that participants’ engagement with and perceived social support from our Facebook group intervention would predict smoking reduction.</p>
      </sec>
      <sec sec-type="methods">
        <title>Methods</title>
        <p>We recruited 16 regular smokers who live in the United States and who were motivated in quitting smoking at screening. We promoted message exposure as well as engagement and social support systems throughout the intervention. For message exposure, we posted prevalidated, antismoking messages (such as national antismoking campaigns) on our smoking reduction and cessation Facebook group. For engagement and social support systems, we delivered a high degree of engagement and social support systems during the second and third week of the intervention and a low degree of engagement and social support systems during the first and fourth week. A total of six surveys were conducted via Amazon Mechanical Turk (MTurk) at baseline on a weekly basis and at a 2-week follow-up.</p>
      </sec>
      <sec sec-type="results">
        <title>Results</title>
        <p>Of the total 16 participants, most were female (n=13, 81%), white (n=15, 94%), and between 25 and 50 years of age (mean 34.75, SD 8.15). There was no study attrition throughout the 6-time-point baseline, weekly, and follow-up surveys. We generated Facebook engagement and social support composite scores (mean 19.19, SD 24.35) by combining the number of likes each participant received and the number of comments or wall posts each participant posted on our smoking reduction and cessation Facebook group during the intervention period. The primary outcome was smoking reduction in the past 7 days measured at baseline and at the two-week follow-up. Compared with the baseline, participants reported smoking an average of 60.56 fewer cigarettes per week (SD 38.83) at the follow-up, and 4 participants out of 16 (25%) reported 7-day point prevalence smoking abstinence at the follow-up. Adjusted linear regression models revealed that a one-unit increase in the Facebook engagement and social support composite scores predicted a 0.56-unit decrease in cigarettes smoked per week (standard error <italic>=</italic>.24, <italic>P</italic>=.04, 95% CI 0.024-1.09) when baseline readiness to quit, gender, and baseline smoking status were controlled (<italic>F</italic><sub>4, 11</sub>=8.85, <italic>P</italic>=.002).</p>
      </sec>
      <sec sec-type="conclusions">
        <title>Conclusions</title>
        <p>This study is the first Facebook group–based intervention that systemically implemented health communication strategies and engagement and social support systems to promote smoking reduction and cessation. Our findings imply that receiving one like or posting on the Facebook-based intervention platform predicted smoking approximately one less cigarette in the past 7 days, and that interventions should facilitate user interactions to foster user engagement and social support.</p>
      </sec>
    </abstract>
    <kwd-group>
      <kwd>social media</kwd>
      <kwd>social support</kwd>
      <kwd>behavior and behavior mechanisms</kwd>
      <kwd>smoking cessation</kwd>
      <kwd>persuasive communication</kwd>
      <kwd>social networking</kwd>
      <kwd>technology</kwd>
      <kwd>health promotion</kwd>
    </kwd-group></article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>Tobacco use is the primary cause of premature mortality and is responsible for almost half a million deaths every year in the United States and nearly 5 million deaths globally [<xref ref-type="bibr" rid="ref1">1</xref>]. Although mass media–based (eg, TV, radio) health campaigns have been moderately effective for health promotion—influencing 4% to 8% of the population to change health behaviors [<xref ref-type="bibr" rid="ref2">2</xref>]—several considerable drawbacks remain. First, mass media–based approaches for public health promotion, such as tobacco control and prevention campaigns, fall short in enabling a frequent and durable delivery system that can disseminate individually tailored messages. Second, a message exposure tracking system is often nonexistent or costly in traditional mass media settings. Thus, it is difficult to directly gauge the effects of mass media exposure to health messages on health behavior. Third, traditional media platforms offer a limited to nonexistent interactive engagement system that could enhance social support and user-centered engagement.</p>
        <p>Significant advances in social media technologies and their ubiquity offer novel opportunities to provide geographically distant users with easily accessible, cost-effective, personalized health content, and social network-based support. For example, Facebook, one of the most widely adopted social media platforms, hosts approximately 1.22 billion daily active users [<xref ref-type="bibr" rid="ref3">3</xref>] and has an enormous quantity of user-initiated virtual communities that are highly relevant to people seeking social support for health problems [<xref ref-type="bibr" rid="ref4">4</xref>]. The magnitude of this social network platform and its popularity can considerably extend the reach of evidence-based health messages to the public and scale-up user-centered social support to the population level to address public health problems. In fact, a growing volume of research is leveraging social media to facilitate health behavior changes such as increasing physical activities [<xref ref-type="bibr" rid="ref5">5</xref>], enabling addiction recovery support [<xref ref-type="bibr" rid="ref6">6</xref>], providing support for cancer survivors [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref8">8</xref>], and reducing sexual risk behaviors among youth [<xref ref-type="bibr" rid="ref9">9</xref>]. More evidence has shown that participants perceive social media approaches for health promotion as appealing, acceptable, and convenient [<xref ref-type="bibr" rid="ref10">10</xref>].</p>
        <p>In this regard, social media such as Facebook provide a range of communication features for putative processes of behavior change that are important to individuals with health problems. Those social media features and related processes include “posting” features for self-disclosure [<xref ref-type="bibr" rid="ref11">11</xref>], search functions via hashtags for information-seeking [<xref ref-type="bibr" rid="ref12">12</xref>], “share” features for social sharing [<xref ref-type="bibr" rid="ref13">13</xref>], and using “comment” and “reaction” features for engagement and social support [<xref ref-type="bibr" rid="ref14">14</xref>-<xref ref-type="bibr" rid="ref16">16</xref>]. Strategic use of social media features that facilitates these processes may foster desirable health outcomes [<xref ref-type="bibr" rid="ref17">17</xref>].</p>
        <p>Facebook groups, in particular, can be used as a designated online social support community for members with similar health concerns [<xref ref-type="bibr" rid="ref18">18</xref>]. They provide various social interaction features such as “likes” and “comments” for group members. Feedback “comments” from group members and clinicians as well as reciprocated interactivities can create a supportive environment for achieving health promotion [<xref ref-type="bibr" rid="ref4">4</xref>]. Researchers can also track whether the target audiences view the intervention content and observe social dynamics among group members in adopting health attitudes and behaviors.</p>
        <p>In this study, we utilized Facebook group features to effectively disseminate prevalidated antismoking messages with high frequency and longitudinal exposure. Message exposure frequency and exposure duration are pivotal factors for successful health campaigns [<xref ref-type="bibr" rid="ref19">19</xref>] that are often limited in traditional mass media environments. In addition, we harnessed multidirectional communication processes among intervention target participants (smokers) to foster user-centered engagement and social support.</p>
        <p>Despite the potential benefits of harnessing social media for health interventions, a critical gap in knowledge persists in terms of how to best utilize social media features to achieve positive health intervention outcomes. The intent of this study is to strategically leverage communication features that are available on Facebook groups to implement a smoking reduction and cessation intervention among regular smokers who are interested in quitting. For our intervention, we promoted smoking cessation as the optimal outcome to achieve, but we also accepted smoking reduction as a positive change for those who could not immediately quit smoking, as smoking reduction is a common step toward eventual cessation [<xref ref-type="bibr" rid="ref20">20</xref>]. In doing so, we designed a smoking reduction and cessation intervention through a Facebook group with two primarily theory-guided intervention components: (1) message exposure to antismoking media content in a systematic manner while strategically changing messaging frequency (high vs low), and (2) social support and engagement systems with different levels (high vs low).</p>
      </sec>
      <sec>
        <title>Exposure to Antismoking Messages</title>
        <p>Prior studies on health promotions and health behavior models have demonstrated that exposure to health communications can enhance one’s health behavior by changing core beliefs and attitudes about expected health outcomes [<xref ref-type="bibr" rid="ref21">21</xref>], by providing education on the skills needed to change health behavior [<xref ref-type="bibr" rid="ref22">22</xref>], and by disseminating knowledge about the target health behavior [<xref ref-type="bibr" rid="ref23">23</xref>]. In realizing these intermediate factors for behavior change, acquiring exposure to intervention messages is the most important requisite condition for successful health promotion [<xref ref-type="bibr" rid="ref24">24</xref>]. This study targeted systematic, frequent exposure to antismoking messages as a key factor. We posited that strategic exposure to antismoking messages could influence the target audience to form positive beliefs and behaviors about smoking reduction and cessation [<xref ref-type="bibr" rid="ref25">25</xref>]. Different from traditional media environments, leveraging social media as a communication platform for a health intervention enables investigators to predesign and administer the frequency and delivery schedule of message exposure in a systematic manner (eg, one-time message exposure at the same time of the day). Social media also enable interventionists to disseminate campaign messages to geographically distant audiences. For our Facebook group–based intervention messages, we aimed to use preexisting, well-received antismoking campaign messages (eg, the Tips From Former Smokers campaign) rather than generating a new set of antismoking messages. In order to reduce the cost, time, and risks associated with developing new campaign content, the CDC’s (Centers for Disease Control and Prevention) best practice guidelines for tobacco control and prevention campaigns recommend reuse of existing campaign messages that have shown positive campaign outcomes [<xref ref-type="bibr" rid="ref1">1</xref>].</p>
      </sec>
      <sec>
        <title>Social Support and User Engagement</title>
        <p>Social support and engagement systems were additional theoretical components that were applied in our Facebook group–based smoking reduction and cessation intervention. Social support is defined as informational, emotional, reassuring, or tangible resources [<xref ref-type="bibr" rid="ref26">26</xref>] provided by professional or nonprofessional social capital. Social support has been shown to be one of the most considerable coping resources for achieving desirable health outcomes [<xref ref-type="bibr" rid="ref27">27</xref>], including behavioral health [<xref ref-type="bibr" rid="ref28">28</xref>], physical health [<xref ref-type="bibr" rid="ref5">5</xref>], and mental health [<xref ref-type="bibr" rid="ref29">29</xref>]. Social media can be an excellent outlet for active user engagement and peer-to-peer health support [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref31">31</xref>]. Social media technologies offer various communication and social networking features that individuals can use to share their health concerns and engage their social networks for support [<xref ref-type="bibr" rid="ref30">30</xref>]. In the intervention, we implemented health communication strategies to deliver social support and user engagement systems, which in turn may foster smoking reduction and cessation [<xref ref-type="bibr" rid="ref32">32</xref>]</p>
        <p>Based on the four dimensions of the social support conceptual framework [<xref ref-type="bibr" rid="ref33">33</xref>], we operationalized three types of social support constructs—emotional support, informational support, and reassuring support—through comments and wall postings on our smoking reduction and cessation Facebook group. For emotional support, we showed an empathic understanding of the issues of participants (eg, We know how hard it is to quit smoking, and understand what you are going through). To operationalize informational support, we appraised the participants’ circumstances and posted advising comments on topics ranging from nicotine craving symptoms to possible solutions (eg, Here are some tips for managing cravings), and we also provided reassuring support by assuring self-confidence to the participants through affirmative comments (eg, You can do it!).</p>
        <p>One’s perceived social support can help them enhance their self-efficacy beliefs in order to overcome barriers to adopting the health behavior being promoted. To deliver social support and engagement in relation to promoting smoking reduction and cessation during the 4-week intervention period, we manipulated the level of engagement and social support systems (high vs low) and juxtaposed it with high versus low message exposure.</p>
      </sec>
      <sec>
        <title>Specific Objectives</title>
        <p>We examined the feasibility of a Facebook group–based smoking reduction and cessation intervention. Additionally, the preliminary efficacy on smoking reduction (the reduced number of cigarettes consumed per week) and on 7-day point smoking abstinence at the follow-up was tested. We also tested whether the intervention components (social support and engagement systems) predict smoking reduction.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Recruitment</title>
        <p>Recruitment messages and preliminary screening questions were disseminated through Amazon Mechanical Turk (MTurk) and social media platforms. MTurk is an anonymous Web-based labor market with over 500,000 registered workers worldwide. MTurk workers complete tasks distributed by requesters for small financial rewards. MTurk has been used as a recruitment pool in various fields of research for an array of tasks, including decision-making [<xref ref-type="bibr" rid="ref34">34</xref>-<xref ref-type="bibr" rid="ref36">36</xref>], health literacy [<xref ref-type="bibr" rid="ref37">37</xref>], and natural language processing tasks [<xref ref-type="bibr" rid="ref38">38</xref>].</p>
      </sec>
      <sec>
        <title>Inclusion Criteria</title>
        <p>Over 200 applicants who were interested in our four-week smoking reduction and cessation interventions were screened based on their self-reported characteristics. The inclusion criteria were regular smokers (smoking 5 days per week) who were between the ages of 18 and 65 years and living in the United States. To be eligible, participants had to have no chronic disease interfering with their daily lives, no use of illicit drugs, and be motivated to quit smoking (&#62; 80, on a 100-point motivation to quit smoking scale [<xref ref-type="bibr" rid="ref39">39</xref>]). To ensure that access to and use of Facebook were not barriers to participate in the intervention, participants had to have Internet access and had to use Facebook through their mobile or computer devices on a regular basis.</p>
        <p>Qualified applicants (N=132) were invited to participate in our study. The eligible participants who responded to our invitation (N=46) were randomly assigned to one of the following conditions: email condition, MTurk-only condition, or the Facebook condition. Participants were introduced to their intervention and coached on how to participate in it. This report focuses on the subjects who were randomized to the Facebook condition (n=16) in order to give special attention to the findings that are unique due to the social media features exclusively available on Facebook (eg, comments, share, likes, and wall postings). Primary outcomes from all three conditions will be published in a separate report.</p>
      </sec>
      <sec>
        <title>Intervention Guidelines</title>
        <p>Participants were first provided with an electronic informed consent form. Before the start date of the intervention, researchers contacted consenting individuals through an individual phone call meeting and provided guidelines in greater detail on how to participate in the Facebook intervention. For example, participants were encouraged to share their thoughts, progress, and peer support. We also provided practical methods on engaging with the intervention materials on a daily basis by leaving comments, liking posts, and interacting with other peers in the group throughout the four-week intervention period. The participants were informed that there is no incentive for intervention engagement in our smoking reduction and cessation Facebook group. We informed participants that our research members would post different antismoking messages throughout the intervention period and provide social support to keep participants motivated to engage in action for smoking reduction and cessation. In addition, on the start date, the research team greeted all participants on the Facebook group wall by posting encouraging statements such as “…If you are having a hard time quitting, let us hear. We are here to support you and encourage you to achieve your goal.” This greeting statement was used to set a positive tone and an atmosphere inclusive of all participants. All procedures, materials, and study protocols were reviewed and approved by the university’s Institutional Review Board.</p>
      </sec>
      <sec>
        <title>Research Design of the Smoking Reduction and Cessation Facebook Group</title>
        <p>We implemented and targeted different levels of message exposure and engagement and social support systems over four weeks. During week 1 (high message exposure combined with low engagement and social support), we posted antismoking messages three times per day without directly encouraging people to respond to the materials or share their thoughts. During week 2 (low message exposure combined with high engagement and social support), we posted antismoking materials once per day and delivered supportive comments and fostered user engagement by directly asking participants to share their motivating factors, their thoughts on posted antismoking messages, and their progress on quitting smoking with the group. During week 3 (high message exposure combined with high engagement and social support), we posted antismoking messages three times per day. In addition, a professional clinical expert joined the Facebook group and provided guidance on smoking reduction and cessation as well as methods to cope with nicotine withdrawal. We also continued our targeted engagement and social support communications by asking people to share their thoughts toward the guidance. During the last week (low message exposure and low engagement and social support), we posted antismoking materials once per day that focused on mindfulness, self-regulatory tips, and resources for smoking reduction and cessation. Participants were blinded from the intention of the intervention designs regarding message exposure frequency and levels of engagement and social support systems.</p>
      </sec>
      <sec>
        <title>Stimulus Materials for Antismoking Message Exposure</title>
        <p>In order to prepare intervention materials to be disseminated on our smoking reduction and cessation Facebook group for four weeks, a total of 80 different antismoking advertisements, campaign messages, and news articles were collected from publicly available online sources, such as smokefree.gov, cancer.gov, and the CDC’s Media Campaign Resource Center (MCRC), a rich database with more than 10,000 antismoking ads produced by different states and federal agencies. The collected antismoking materials were either video-based or text-and-image-based materials that have shown population-level success or promising evidence on promoting tobacco control and prevention (eg, the “Tips From Former Smokers” campaign). To select the final set of intervention materials, in a separate MTurk-based randomized experiment, we evaluated the relative effectiveness of 80 antismoking materials among 1288 smokers prior to the interventions. Based on composite scores of message effectiveness and post-antismoking attitudes toward randomly assigned antismoking material, a total of 56 antismoking messages out of the 80 units were selected as intervention materials (3 messages × 7 days for the first week, 1 message × 7 days for the second week, 3 messages × 7 days for the third week, and 1 message × 7 days for the last week).</p>
        <p>The 56 units of antismoking messages were posted in a random order on our smoking reduction and cessation Facebook group. Based on the ongoing feedback from our participants and weekly surveys, 5 message units of these 56 (approximately 9%) were replaced with other antismoking materials to correspond to the needs of participants (eg, asking for more information on smoking cessation tips).</p>
        <p><bold>Systematic Delivery of Evidence-Based Antismoking Materials</bold></p>
        <p>Our smoking reduction and cessation Facebook group intervention started in late November 2015 and ended in early January 2016. We delivered antismoking materials with different frequencies across four intervention weeks (as described above) but with fixed time schedules: 8:00 AM, 12:00 PM, and 5:00 PM (Pacific Time) for the first and third week; and 11:00 AM (Pacific Time) for the second and fourth week.</p>
        <p><bold>Engagement and Social Support Systems via Social Media Features</bold></p>
        <p>In addition to using social media as an intervention modality where participants were exposed to antismoking messages frequently, the research team utilized communication features on the Facebook group, such as pressing the “like” button to express support and affective responses toward users’ wall postings and comments and leaving “comments” to provide constructive feedback. These activities were implemented to synchronously reciprocate them with information and foster social support and user engagement.</p>
      </sec>
      <sec>
        <title>Research Assessments</title>
        <p>A baseline survey, all weekly surveys administered during the four-week intervention period, and a two-week follow-up survey were conducted to participants via MTurk by using the “qualification type” function on MTurk. This function made the survey available only to our intervention participants. Participants were compensated with US $8 for each baseline and weekly survey and US $15 for the two-week follow-up survey for a total of US $55 over the study period. The median values of the time spent by participants on survey assessments throughout the entire intervention period ranged between 4.21 minutes and 13.96 minutes.</p>
      </sec>
      <sec>
        <title>Demographic and Smoking Characteristics at Baseline</title>
        <p>Demographic information such as age, gender, marital status, ethnicity, and race, self-reported smoking status (the average number of cigarettes participants smoked in the past 7 days), motivation to quit [<xref ref-type="bibr" rid="ref39">39</xref>], and behavioral intention to quit smoking [<xref ref-type="bibr" rid="ref40">40</xref>] were assessed at baseline. The readiness to quit smoking was also measured on a 10-point Likert scale [<xref ref-type="bibr" rid="ref41">41</xref>], where scores between 1 and 3 reflect low readiness to quit (eg, “I don’t want to quit. Tobacco is not a problem for me.”); the range between 4 and 7 indicates moderate readiness to quit (eg, “I know quitting would be good for my health. I am interested in advice about quitting.”); and the scores between 7 and 10 indicate high readiness to quit (eg, “I am ready to quit using tobacco. I would like help to quit using tobacco.”).</p>
      </sec>
      <sec>
        <title>Data Analysis: Facebook ESSC Scores, Smoking Reduction and Cessation</title>
        <sec>
          <title>Primary Outcomes</title>
          <p>The primary outcome was self-reported smoking reduction reported at baseline and the last follow-up (adopted from [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref43">43</xref>] and modified for the study). The number of cigarettes participants smoked per week measured at follow-up was subtracted from that measured at baseline to compute the reduced number of weekly cigarettes consumed per participant. Another primary outcome was smoking cessation (7-day point smoking abstinence at the follow-up).</p>
        </sec>
        <sec>
          <title>Predictor Variable (Facebook ESSC [/ˈesit/] Scores)</title>
          <p>For the key independent variable, we constructed individual-level Facebook engagement and social support composite scores (referred to as “Facebook ESSC Scores” hereafter) to capture user engagement and the social support received from our Facebook group. The Facebook ESSC score was aggregated for each participant by combining the number of postings each participant generated (both wall postings and comments) and the number of “likes” each participant received during the intervention period. Two trained coders verified the number of likes each participant received and the number of comments or wall posts each participant made. The two coders reached a consensus on these results.</p>
        </sec>
        <sec>
          <title>Secondary Outcomes</title>
          <p>Secondary constructs measured at baseline, weekly, and follow-up surveys include the antismoking attitudes scale on a 7-point semantic differential scale [<xref ref-type="bibr" rid="ref44">44</xref>], readiness to quit on a 10-point Likert scale [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref45">45</xref>], motivation to quit [<xref ref-type="bibr" rid="ref39">39</xref>], self-efficacy beliefs on a 7-point Likert scale (adopted from Wei et al study [<xref ref-type="bibr" rid="ref46">46</xref>] and modified for the study), and perceived social support on a 5-point Likert scale [<xref ref-type="bibr" rid="ref47">47</xref>]. In all of these scales, higher values indicate positive attitudes toward smoking, greater readiness to quit smoking, greater belief in self-efficacy, and greater perceived social support, respectively.</p>
        </sec>
        <sec>
          <title>Facebook Intervention Feasibility Inventory</title>
          <p>We generated the Facebook Intervention Feasibility Inventory by adopting and modifying questionnaires from usability and acceptability scales that were validated in the mHealth intervention context [<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref50">50</xref>]. The Facebook Intervention Feasibility Inventory was designed to measure the perceived feasibility of using a Facebook group for smoking reduction and cessation interventions with 24 randomly ordered items on a 7-point Likert scale at follow-up. Examples of responses include statements such as “I thought the anti-smoking Facebook Group was easy to use.” and “I felt very confident using the Anti-smoking Facebook Group.”</p>
        </sec>
        <sec>
          <title>User Engagement Patterns and Message Exposure Tracking</title>
          <p>We monitored participants’ engagement with the intervention content and other members by looking at the frequency of postings and “likes” that participants generated on the Facebook group. Due to limited access to extract user data specific to “seen by” activities, our trained research members counted the number of “seen by” activities per post. We also unobtrusively observed participants’ exposure to intervention messages by checking the “seen by” feature on a daily basis, which enabled the research team to track whether each user had seen the materials posted on the wall of our Facebook group.</p>
        </sec>
        <sec>
          <title>Statistical Analysis</title>
          <p>R package version 3.2.5 [<xref ref-type="bibr" rid="ref51">51</xref>] and IBM SPSS statistics version 22 [<xref ref-type="bibr" rid="ref52">52</xref>] were used for statistical analyses. Descriptive analyses were first performed on the demographic variables, predictors, and primary and secondary outcomes to summarize distributions and patterns of each construct. For the primary outcome, we ran adjusted regression analyses to examine the relationship between the predictor and the primary outcome variable while controlling for baseline covariates (gender, readiness to quit, and smoking status, ie, the number of cigarettes participants smoked in the past 7 days at baseline). For secondary outcome variables, we performed General Linear Model (GLM) analysis with repeated measures to explore the main effects of Facebook ESSC scores on repeated secondary outcomes while controlling for the same baseline covariates. We performed a confirmatory factor analysis with an oblimin rotation on the Facebook intervention feasibility questionnaires. A bivariate correlation matrix was computed to examine reliability coefficients between predictors, smoking reduction, and Facebook feasibility subfactors. We also used various R packages and publicly available online software for data visualization to demonstrate participants’ engagement trends based on the total number of postings aggregated throughout the intervention period.</p>
        </sec>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Demographic and Smoking Characteristics at Baseline</title>
        <p>The majority of participants were white (n=15, 94%), female (n=13, 81%), and between 25 and 50 years old (mean 34.75, SD 8.15). On average, participants smoked 11.31 cigarettes per day (SD 6.81) and 6.93 days per week (SD 0.25) at baseline. The degree of readiness scores for smoking cessation was 7.50 (SD 1.59), which indicates high readiness to quit smoking. During the past 12 months prior to baseline, participants stopped smoking 1.81 times (SD 1.47 times) for at least one day or longer. The 7-item antismoking attitude scale at baseline had a high inter-reliability (Cronbach alpha=.91) and loaded on a single confirmatory factor (with an eigenvalue=4.965 with 70% variances being explained by this one factor). Thus, we created a composite score (mean 2.37, SD 1.22): lower values indicate strong antismoking attitudes, such as smoking cigarettes is “bad, useless, and harmful for my health”; and higher values indicate positive attitudes toward smoking, such as smoking cigarettes is “good, beneficial, and useful.”</p>
      </sec>
      <sec>
        <title>Facebook ESSC Scores, Smoking Reduction and Cessation</title>
        <p>All participants (N=16) completed all 6-time-point surveys. Descriptive statistics of predictors (Facebook ESSC scores), primary and secondary outcomes, and Facebook intervention feasibility questionnaires are presented in <xref ref-type="table" rid="table1">Table 1</xref>. Compared with the baseline, participants reported smoking an average of 60.56 fewer cigarettes per week (SD 38.83) at the follow-up, and 25% of the participants reported 7-day point smoking abstinence at the follow-up. Facebook engagement and social support composite scores (Facebook ESSC scores) were generated (mean 19.19, SD 24.35). The final adjusted linear regression model revealed that a one-unit increase in Facebook ESSC scores predicted a 0.56 unit decrease in cigarettes consumed in the past 7 days (standard error, SE=.24, <italic>P</italic>=.04, 95% CI 0.024-1.09) when baseline covariate characteristics were controlled, <italic>F</italic><sub>4, 11</sub>=8.85, <italic>P</italic>=.002, adjusted R<sup>2</sup>=.68.</p>
      </sec>
      <sec>
        <title>Composite Scores of Secondary Outcomes and Exploratory Analyses</title>
        <p>Seven-item antismoking attitudes showed a high reliability for each time-point survey, ranging from Cronbach alpha=.91 to .99. Thus, we created a composite score for each time-point. Similarly, 5-item self-efficacy questionnaires had a high reliability for each time-point survey, ranging from Cronbach alpha=.88 to .98. We generated a composite score for self-efficacy beliefs measured at each time-point of the surveys. For perceived social support questionnaires, five items were averaged to a single factor for each time-point survey after verifying a good reliability score for each survey (Cronbach alpha scores ranged from .84 to .92). The descriptive statistics of secondary outcomes are reported in <xref ref-type="table" rid="table1">Table 1</xref>. Exploratory GLM analysis with repeated measures revealed that Facebook ESSC scores were not significant predictors of secondary outcomes when the baseline covariates were adjusted (<italic>Fs</italic>&#60;1).</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Predictors, primary and secondary outcomes, and Facebook feasibility.</p>
          </caption>
          <table width="750" cellpadding="7" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="15"/>
            <col width="80"/>
            <col width="29"/>
            <col width="29"/>
            <col width="29"/>
            <col width="29"/>
            <col width="29"/>
            <col width="32"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Variables</td>
                <td>Statistics</td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="2"><bold>Predictors</bold></td>
                <td>Mean (SD)</td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Number of Facebook “likes” received</td>
                <td>13.25 (17.67)</td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Number of Facebook “comments/wall posts” generated</td>
                <td>5.94 (6.96)</td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Number of Facebook engagement scores</td>
                <td>19.19 (24.35)</td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td><break/></td>
                <td>Baseline</td>
                <td>Week 1</td>
                <td>Week 2</td>
                <td>Week 3</td>
                <td>Week 4</td>
                <td>Follow-up</td>
              </tr>
              <tr valign="top">
                <td colspan="2"><bold>Primary outcomes</bold></td>
                <td/>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Mean number of cigarettes smoked per week among smokers mean (SD)</td>
                <td>79.19 (47.66)</td>
                <td>44.38 (60.09)</td>
                <td>32.44 (44.42)</td>
                <td>29.81 (41.84)</td>
                <td>20.44 (36.51)</td>
                <td>18.63 (35.33)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Number of people who quit smoking in the past 7 days, n (%)</td>
                <td>0 (0)</td>
                <td>0 (0)</td>
                <td>2 (13)</td>
                <td>3 (19)</td>
                <td>3 (19)</td>
                <td>4 (25)</td>
              </tr>
              <tr valign="top">
                <td colspan="2"><bold>Secondary outcomes, mean (SD)</bold></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Mean Antismoking attitude scale score</td>
                <td>2.37 (1.22)</td>
                <td>1.76 (1.33)</td>
                <td>1.73 (1.34)</td>
                <td>1.66 (1.32)</td>
                <td>1.60 (1.51)</td>
                <td>1.60 (1.53)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Mean self-efficacy for smoking cessation scale score</td>
                <td>–</td>
                <td>6.06 (0.70)</td>
                <td>5.83 (0.83)</td>
                <td>6.18 (0.75)</td>
                <td>6.40 (0.67)</td>
                <td>6.05 (1.50)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Mean score on readiness to quit item</td>
                <td>7.50 (1.59)</td>
                <td>8.19 (1.22)</td>
                <td>7.88 (1.59)</td>
                <td>7.94 (1.53)</td>
                <td>8.63 (1.20)</td>
                <td>8.56 (1.41)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Mean perceived social support scale score</td>
                <td>–</td>
                <td>3.95 (0.87)</td>
                <td>4.10 (0.64)</td>
                <td>4.03 (0.79)</td>
                <td>4.18 (0.84)</td>
                <td>3.89 (0.88)</td>
              </tr>
              <tr valign="top">
                <td colspan="2"><bold>Facebook intervention feasibility questionnaires, mean (SD)</bold></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Response efficacy (alpha =.96)</td>
                <td>–</td>
                <td>–</td>
                <td>–</td>
                <td>–</td>
                <td>–</td>
                <td>5.47 (1.20)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Perceived technology barriers (alpha=.97)</td>
                <td>–</td>
                <td>–</td>
                <td>–</td>
                <td>–</td>
                <td>–</td>
                <td>2.23 (1.45)</td>
              </tr>
              <tr valign="top">
                <td> </td>
                <td>Easiness to use (alpha=.96)</td>
                <td>–</td>
                <td>–</td>
                <td>–</td>
                <td>–</td>
                <td>–</td>
                <td>6.02 (0.98)</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Correlations across predictors, smoking reduction, and Facebook feasibility subfactors. Facebook engagement and social support composite scores (Facebook ESSC scores) are combined values of the number of Facebook “likes” one received (1 in the table) and the number of Facebook “comments” and “wall postings” each person generated (2 in the table).</p>
          </caption>
          <table width="669" cellpadding="7" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="8"/>
            <col width="281"/>
            <col width="1"/>
            <col width="65"/>
            <col width="1"/>
            <col width="45"/>
            <col width="1"/>
            <col width="45"/>
            <col width="1"/>
            <col width="45"/>
            <col width="1"/>
            <col width="45"/>
            <col width="1"/>
            <col width="42"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Variables</td>
                <td colspan="2">1</td>
                <td colspan="2">2</td>
                <td colspan="2">3</td>
                <td colspan="2">4</td>
                <td colspan="2">5</td>
                <td colspan="2">6</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>1</td>
                <td colspan="2">Number of Facebook “likes” received</td>
                <td colspan="2">–</td>
                <td colspan="2"><break/></td>
                <td colspan="2"><break/></td>
                <td colspan="2"><break/></td>
                <td colspan="2"><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td>2</td>
                <td colspan="2">Number of Facebook “comments/wall posts” generated</td>
                <td colspan="2">.95<sup>a</sup></td>
                <td colspan="2">–</td>
                <td colspan="2"><break/></td>
                <td colspan="2"><break/></td>
                <td colspan="2"><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td>3</td>
                <td colspan="2">Facebook ESSC scores</td>
                <td colspan="2">.996<sup>a</sup></td>
                <td colspan="2">.97<sup>a</sup></td>
                <td colspan="2">–</td>
                <td colspan="2"><break/></td>
                <td colspan="2"><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td>4</td>
                <td colspan="2">Reduced number of cigarettes smoked</td>
                <td colspan="2">.49<sup>c</sup></td>
                <td colspan="2">.48</td>
                <td colspan="2">.49<sup>c</sup></td>
                <td colspan="2">–</td>
                <td colspan="2"><break/></td>
                <td/>
              </tr>
              <tr valign="top">
                <td>5</td>
                <td colspan="2">Facebook response efficacy</td>
                <td colspan="2">−.19</td>
                <td colspan="2">.01</td>
                <td colspan="2">−.01</td>
                <td colspan="2">.14</td>
                <td colspan="2">–</td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td>6</td>
                <td colspan="2">Perceived technology barriers</td>
                <td colspan="2">−.34</td>
                <td colspan="2">−.35</td>
                <td colspan="2">−.34</td>
                <td colspan="2">−.56<sup>b</sup></td>
                <td colspan="2">.12</td>
                <td>–</td>
              </tr>
              <tr valign="top">
                <td>7</td>
                <td colspan="2">Easiness to use</td>
                <td colspan="2">.24</td>
                <td colspan="2">.20</td>
                <td colspan="2">.23</td>
                <td colspan="2">.35</td>
                <td colspan="2">.62<sup>b</sup></td>
                <td>−.15</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table2fn1">
              <p><sup>a</sup><italic>P</italic>&#60;.01.</p>
            </fn>
            <fn id="table2fn2">
              <p><sup>b</sup><italic>P</italic>&#60;.05.</p>
            </fn>
            <fn id="table2fn3">
              <p><sup>c</sup><italic>P</italic>=.05.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Factor Analysis on Facebook Intervention Feasibility Questionnaires</title>
        <p>A confirmatory factor analysis with a direct oblimin rotation was performed on the 24-item Facebook intervention feasibility questionnaires. Items within each subfactor with loading scores greater than 0.6 were averaged to compose three subconcepts under the umbrella concept of perceived Facebook feasibility for health interventions. Those subfactors represent Facebook response efficacy (alpha=.96), perceived barriers of using Facebook (alpha=.97), and easiness of using Facebook for smoking reduction and cessation interventions (alpha=.96), respectively (<xref ref-type="table" rid="table1">Table 1</xref> for descriptive analyses). Bivariate correlation coefficients between these feasibility subfactors and predictors and primary outcomes are presented in <xref ref-type="table" rid="table2">Table 2</xref>. Participants with low perceived barriers of using the Facebook Group tend to have greater reduction in weekly cigarette smoking compared to those with high perceived barriers of using the Facebook group intervention (Pearson <italic>r</italic>=−.56, <italic>P</italic>=.02).</p>
      </sec>
      <sec>
        <title>User Engagement Patterns and Message Exposure Tracking</title>
        <p><xref ref-type="fig" rid="figure1">Figure 1</xref> presents the aggregated number of postings from participants across the four-week intervention period. The second and third weeks, in which a high level of engagement and social support systems were targeted, demonstrate an increased generation of comments and wall posts by the participants during these two weeks. We proposed that the number of comments and wall posts indicated active user engagement. Note that week 1 and week 4 (low engagement and social support systems) revealed a decreased number of comments and wall posts in the graphic pattern, indicating relatively passive user engagement. After the intervention was over, we received a few posts from participants reporting their success in maintaining smoking cessation, as well as thanking the researchers for their help and requesting further assistance about tips for completely quitting smoking.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>User engagement during the four-week intervention period. The y-axis indicates the number of wall posts and comments participants generated within the smoking reduction and cessation Facebook group. The values are indicative of user engagement.</p>
          </caption>
          <graphic xlink:href="jmir_v19i5e168_fig1.jpg" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings and Comparison With Prior Work</title>
        <p>Using a closed Facebook group, we developed and delivered a smoking reduction and cessation intervention in a cost-effective manner while overcoming geolocational barriers and time constraints. We found that Facebook was highly feasible and we demonstrated 100% study retention and survey completion rates. In this study, 25% of participants reported 7-day smoking abstinence at the follow-up, and those who continued had dramatically reduced the number of cigarettes they smoked weekly. These outcomes are consistent with and comparable with previous studies of Facebook-delivered interventions for smoking [<xref ref-type="bibr" rid="ref53">53</xref>].</p>
        <p>Although we promoted smoking cessation as an optimal outcome for our intervention, we also accepted smoking reduction as a positive form of behavior change. Helping smokers to cut down on cigarette use has been attempted in many controlled trials [<xref ref-type="bibr" rid="ref54">54</xref>]. However, we acknowledge that smoking reduction should be considered as an intermediate precursor to quitting rather than a goal of the intervention because reduced- and light-smoking still carry a considerable level of health risk for cardiovascular disease and cancer, as observed among heavy daily smokers [<xref ref-type="bibr" rid="ref55">55</xref>]. That said, smoking reduction can have a substantial health impact in the long run [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref57">57</xref>]. For example, in a 30-year longitudinal follow-up cohort study, Godtfredsen and colleagues [<xref ref-type="bibr" rid="ref58">58</xref>] found that a 50% smoking reduction significantly decreased lung cancer risk among heavy regular smokers.</p>
        <p>Results also suggest that engagement and receipt of social support within this Facebook health communications intervention predicted smoking reduction among motivated smokers. Specifically, a one-unit increase in Facebook ESSC scores predicted a 0.56 unit decrease in cigarettes consumed in the past 7 days. That is, participants who received more “likes” and those who posted more content on our Facebook group, indicative of social support and user engagement, were more likely to reduce their weekly smoking (<italic>F</italic><sub>4,11</sub>=8.85, <italic>P</italic>=.002, ΔR<sup>2</sup>=.68), suggesting a potential mechanism of action for the intervention.</p>
        <p>We generated the term “Facebook engagement and social support composite scores” (ESSC [/ˈesit/] scores) in this study and tested the predictive validity of the ESSC scores on smoking reduction. The composite score was based on our conceptualization that “writing comments and wall posts” is an indicator of user engagement, as also defined by Facebook [<xref ref-type="bibr" rid="ref59">59</xref>]. We used the “like” feature on Facebook to express our positive reaction toward participants and form perceived social support. The number of likes participants received from the interventionists and other participants within the intervention Facebook group was conceptualized as an index for receiving social support. However, we acknowledge that receiving comments (reciprocity) is not only an indicator of user engagement, but also an indicator of social support (as perceived social support increases when self-disclosed information is reciprocated [<xref ref-type="bibr" rid="ref60">60</xref>]). That is, these two constructs (user engagement and social support) are covarying and correlated constructs as we found in our study (Pearson <italic>r</italic>=.95).</p>
        <p>Given this conceptualization, we were interested in how the user engagement and social support systems worked synergistically to enhance intervention outcomes. Determining whether user engagement is exclusively more important than perceived social support or vice versa for predicting smoking reduction was beyond the scope of our research. Thus, we proposed a composite score by combining them to serve our conceptual approach. In addition, our approach was aligned with the principle from test theory that composite scores are more reliable than individual items [<xref ref-type="bibr" rid="ref61">61</xref>]. Note that the number of likes participants received from peers and interventionists (beta coefficient=.72, SE=.33, <italic>P</italic>=.05) as well as the number of comments and wall posts each participant generated (beta coefficient=2.05, SE=.78, <italic>P</italic>=.02) were independently significant predictors of the reduced number of cigarettes consumed in the past 7 days. We suggest that future work disentangle the unique value of these two constructs and build a prediction model focusing on each construct as a single predictor. We also encourage future research to validate and examine the replicability of this composite score.</p>
        <p>Throughout the intervention period, on average, participants generated six comments during the four-week intervention period (SD 6.96, median 3.50). Thrul and colleague [<xref ref-type="bibr" rid="ref62">62</xref>] found that 79 participants made a total of 718 individual comments during the three-month intervention period, which are about nine comments per participant for three months. When averaged by month, their engagement level is three comments per participant per month. We consider our user engagement level (six comments or wall posts per participant for four-week) is comparable with other social media–based interventions for smoking. In fact, we found that the average number of comments and wall posts were negatively skewed due to observers who did not generate any comments or wall posts (n=6, 37.5%). This proportion of observers is relatively low compared with that reported in Thrul et al’s study [<xref ref-type="bibr" rid="ref62">62</xref>]. On social media health forums, lurking or observing is a common practice [<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref64">64</xref>]. In future studies, we hope to develop and examine engagement strategies specific to targeting these intervention observers.</p>
        <p>To understand how and for whom social media–based interventions work, future work may examine potential moderating factors that impact the relationship between user engagement and intervention outcomes. An array of baseline characteristics have predicted technology-based intervention outcomes [<xref ref-type="bibr" rid="ref65">65</xref>]. These characteristics may include demographic characteristics, personalities and traits (eg, self-regulation [<xref ref-type="bibr" rid="ref66">66</xref>]), and even the stage of change for smoking cessation [<xref ref-type="bibr" rid="ref62">62</xref>]. By investigating moderating factors in future research, researchers may identify subgroups of smokers that may benefit the most from social media–based interventions for smoking reduction and cessation.</p>
        <p>We operationalized two key intervention components to maximize the persuasive effects of social media platforms in promoting smoking reduction and cessation: (1) exposure to antismoking messages and (2) participant engagement and social support systems. Prior studies have demonstrated that exposure to health campaign messages can enhance health behavior by changing one’s beliefs about expected health outcomes [<xref ref-type="bibr" rid="ref67">67</xref>] and by providing educational messages to increase necessary knowledge and skills [<xref ref-type="bibr" rid="ref22">22</xref>]. Message exposure was successful as most of the posted materials were “seen by” almost everyone throughout the intervention weeks, although there was a slight decrease in message exposure during the last week. The diminished message exposure was not surprising but rather consistent with previous social media–based health interventions [<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref68">68</xref>].</p>
        <p>CDC’s Best Practices Report, released in 2014, recommends the reuse of existing advertisements and campaign messages rather than producing new content in order to reduce the cost, time, and untested risks associated with developing new ones [<xref ref-type="bibr" rid="ref1">1</xref>]. In this regard, we focused on systematically delivering evidence-based antismoking messages from existing campaigns and advertisements, which not only helped us save on time and cost but also enabled us to readily examine how message exposure and engagement with the intervention content led to smoking reduction.</p>
        <p>At the time we developed this study, there was no standardized, evidence-based model or framework applicable to designing Facebook group–based interventions for smoking reduction and cessation. Thus, based on prior health communication and technology literature, we developed an intervention model using two main components: “persuasive message exposure” and “supportive engagement systems.” We used a varied frequency of message exposure (three times per day or one time per day), as there was no empirical evidence on the optimal dose of message exposure for a social media–based intervention. We randomly juxtaposed these two components (high vs low message exposure frequency × high vs low engagement and social support) to develop our intervention model. This randomly juxtaposed combination led to four weekly designs, including high message exposure and low engagement and social support systems for week 1; low message exposure and high engagement and social support systems for week 2; high message exposure and high engagement and social support systems for week 3; and low message exposure and low engagement and social support systems for week 4. Our findings should be understood with caution. We did not examine which weeks resulted in the most successful intervention outcome (smoking reduction), but we tested the overall impact of the intervention as a whole (before and after the intervention) on smoking reduction. Thus, the risk of any possible confounding effect due to the varied frequency of message exposure is minimized because we did not test smoking reduction by individual week.</p>
        <p>An interesting finding about user engagement is that although we manipulated the frequency of message exposure, there was no resulting effect on increasing user engagement, as shown in <xref ref-type="fig" rid="figure1">Figure 1</xref>. The targeted engagement and social support systems directly influenced user engagement, not the message exposure frequency. The distinctive weekly patterns shown in <xref ref-type="fig" rid="figure1">Figure 1</xref> highlight the notion that in order to foster active user engagement, a significant predictor of smoking reduction, interventionists should directly target user interactivities. For example, the second week delivered a high level of user engagement by directly asking personally relevant questions and encouraging participants to share their progress with others in the Facebook group [<xref ref-type="bibr" rid="ref69">69</xref>] (eg, “What motivates you to quit smoking?” and “Have you reduced the number of cigarettes today?”). Note that week 2 and week 4 had the same messaging frequency: antismoking message was posted once a day during these two weeks. When controlling for the messaging frequency as once per day, the number of user comments and wall posts (indicative of user engagement) in week 2 was higher than that of user comments and wall posts during week 4. This pattern indicates that interventionists should specifically target user engagement in addition to posting antismoking messages. We encourage researchers to adopt and apply effective persuasion tactics and principles to strategically target user engagement within social media–based health interventions.</p>
        <p>Another strength of the study was 100% study retention throughout the MTurk-linked surveys at six different time points. Various technology features on MTurk, such as qualification assignment and the online payment system allowed us to conduct longitudinal surveys. We demonstrated that MTurk can be a platform for a wide range of research activities, ranging from recruitment of smokers living in the United States to multiple times of follow-up assessments with participants.</p>
      </sec>
      <sec>
        <title>Limitations and Future Directions</title>
        <p>Our findings successfully demonstrated the feasibility of social media technologies to offer smoking reduction and cessation interventions with the strategic delivery of engagement and social support systems. Our findings, however, should be understood within the limitations imposed by research budgets and the scope of the study. We did not objectively verify self-reported abstinence; thus, it is possible that the impact of the intervention may be inflated. The reported outcome on the reduced number of cigarettes per week does not correspond to the same level of reduction in toxicant exposure. In future technology-based interventions for smoking reduction and cessation, researchers should embrace practically feasible methods for measuring objective markers of nicotine toxicology [<xref ref-type="bibr" rid="ref70">70</xref>].</p>
        <p>Our sample size in this study was relatively small. Thus, rather than using a complex modeling approach such as latent growth curve modeling, we simplified our statistical model and directly examined the predictive value of Facebook-mediated engagement and social support in explaining smoking reduction outcomes. The dataset of 16 participants with no missing data still provided enough statistical power to detect the effect of the primary regression model outcomes.</p>
        <p>Another limitation is that the gender and race of our sample were relatively homogeneous, mostly white women. In future research, we hope to replicate the interventions with bigger sample sizes and involve participants with characteristics that are more heterogeneous than the current sample to establish the generalizability and reproducibility of the findings. With an increased sample size, future studies should examine pathways of intervention processes with intermediate factors, such as enhanced self-efficacy and perceived social support, to reflect the dynamics of behavior change [<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref72">72</xref>]. Also, <xref ref-type="fig" rid="figure1">Figure 1</xref> shows different descriptive patterns by week. We did not examine a statistical difference using repeated measures by week on the number of wall posts and comments (user engagement). In future research, we encourage to examine statistical difference on this engagement matrix, and perhaps to design multiple Facebook groups to prevent any potential confounding or spillover effects across weeks.</p>
        <p>We examined the feasibility of the communication features in our Facebook group that were utilized to deliver theory-guided intervention components such as message exposure and engagement and social support systems among the optimal set of participants (self-motivated participants who wanted to quit smoking at baseline). In future work, another important question might be whether social media–based interventions can have a significant impact on enhancing these intermediate factors (eg, enhancing motivation to quit, and pro-quitting attitudes), even among those with low motivation to quit smoking at baseline. If social media–based interventions can successfully enhance those factors and smoking reduction and cessation among participants with low motivation, the expected significance of the interventions can be much greater than this study.</p>
        <p>After our four-week intervention, followed by a two-week follow-up survey, we learned that participants continued to use our Facebook group and some participants expressed that they wanted the interventions for a longer period of time. Social media platforms provide novel opportunities to operationalize persuasive technologies for scalable interventions and to maintain active engagement and long-lasting intervention outcomes [<xref ref-type="bibr" rid="ref18">18</xref>]. Future efforts in this line of research may examine and identify which communication and intervention strategies are most effective in sustaining active user engagement and maintaining long-lasting social ties for supportive networks. Additionally, there are several challenges and questions to consider for the future implementation of this work, including finding an optimal dose and information balance between support providers and support recipients and protecting the privacy of online intervention participants, especially for a large-scale intervention.</p>
        <p>As reviewed, theory-driven and evidence-based interventions using Facebook for health promotions are promising. A growing line of research has shown positive effects of Facebook use on various health outcomes, from smoking cessation [<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref73">73</xref>] and physical activities [<xref ref-type="bibr" rid="ref74">74</xref>] to sexual health promotion [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref75">75</xref>]. The benefits of social media, however, go beyond its technological affordability, scalability, and accessibility. In fact, social media use provides psychological benefits that are essential to fundamental human needs. Researchers from various fields have examined psychological benefits and gratification from using Facebook [<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref76">76</xref>-<xref ref-type="bibr" rid="ref81">81</xref>], such as enhanced self-esteem and psychological well-being [<xref ref-type="bibr" rid="ref78">78</xref>], increased social capital [<xref ref-type="bibr" rid="ref79">79</xref>], and refinement of self-affirming values [<xref ref-type="bibr" rid="ref77">77</xref>]. Furthermore, technology features of Facebook facilitate self-disclosure and reciprocal interactions with others, and these activities have been found to be intrinsically therapeutic and rewarding for humans [<xref ref-type="bibr" rid="ref82">82</xref>]. Although targeting these psychological benefits were not within the scope of our study, and thus were not measured nor manipulated, we hope future work will consider how to actively facilitate these psychological benefits when using Facebook as an intervention tool for health promotions.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>This study is the first Facebook-mediated intervention research that systemically promoted antismoking communication strategies and social support and engagement systems as mechanisms of behavior change within a Facebook group. We conceptualized Facebook “likes” and “wall postings and comments” as the manifestation of social support and user engagement. Our findings imply that receiving one Facebook “like” or posting on the Facebook group at least once predicts almost one less cigarette in the past 7 days. The study supports positive effects of Facebook-mediated communication, engagement and social support systems for smoking reduction and cessation, and highlights the public health potential of social media interventions for scaling-up tobacco control and prevention efforts. It also provides practical guidelines for designing communication strategies and persuasive, social media–based smoking reduction and cessation interventions that might be useful for future research.</p>
      </sec>
    </sec>
  </body>
  <back>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">Facebook ESSC Score</term>
          <def>
            <p>Facebook engagement and social support composite score</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This study was funded by the National Institutes of Health (NIH) NIDA Grant No. P30DA029926 Pilot Core. NIDA had no role in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication. The authors would like to thank Gene Geter for his assistance in data collection, as well as Lamar D Moss for his sharp proofreading and valuable feedback.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <collab>U.S. Department of Health and Human Services</collab>
        </person-group>
        <source>Surgeon General</source>  
        <year>2014</year>  
        <comment>The health consequences of smoking—50 years of progress: a report of the Surgeon General 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://www.surgeongeneral.gov/library/reports/50-years-of-progress/full-report.pdf">https://www.surgeongeneral.gov/library/reports/50-years-of-progress/full-report.pdf</ext-link></comment> </nlm-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Noar</surname>
            <given-names>SM</given-names>
          </name>
        </person-group>
        <article-title>A 10-year retrospective of research in health mass media campaigns: where do we go from here?</article-title>
        <source>J Health Commun</source>  
        <year>2006</year>  
        <volume>11</volume>  
        <issue>1</issue>  
        <fpage>21</fpage>  
        <lpage>42</lpage>  
        <pub-id pub-id-type="doi">10.1080/10810730500461059</pub-id>
        <pub-id pub-id-type="medline">16546917</pub-id>
        <pub-id pub-id-type="pii">H6Q277205W1540U0</pub-id></nlm-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <nlm-citation citation-type="web">
        <source>Statista</source>  
        <year>2016</year>  
        <access-date>2017-01-02</access-date>
        <comment>Leading social networks worldwide as of January 2016, ranked by number of active users 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://www.statista.com/statistics/272014/global-social-networks-ranked-by-number-of-users/">https://www.statista.com/statistics/272014/global-social-networks-ranked-by-number-of-users/</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6nCrZGfxF"/></comment> </nlm-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Nabi</surname>
            <given-names>RL</given-names>
          </name>
          <name name-style="western">
            <surname>Prestin</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>So</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>Facebook friends with (health) benefits? exploring social network site use and perceptions of social support, stress, and well-being</article-title>
        <source>Cyberpsychol Behav Soc Netw</source>  
        <year>2013</year>  
        <month>10</month>  
        <volume>16</volume>  
        <issue>10</issue>  
        <fpage>721</fpage>  
        <lpage>7</lpage>  
        <pub-id pub-id-type="doi">10.1089/cyber.2012.0521</pub-id>
        <pub-id pub-id-type="medline">23790356</pub-id></nlm-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Cavallo</surname>
            <given-names>DN</given-names>
          </name>
          <name name-style="western">
            <surname>Tate</surname>
            <given-names>DF</given-names>
          </name>
          <name name-style="western">
            <surname>Ries</surname>
            <given-names>AV</given-names>
          </name>
          <name name-style="western">
            <surname>Brown</surname>
            <given-names>JD</given-names>
          </name>
          <name name-style="western">
            <surname>DeVellis</surname>
            <given-names>RF</given-names>
          </name>
          <name name-style="western">
            <surname>Ammerman</surname>
            <given-names>AS</given-names>
          </name>
        </person-group>
        <article-title>A social media-based physical activity intervention: a randomized controlled trial</article-title>
        <source>Am J Prev Med</source>  
        <year>2012</year>  
        <month>11</month>  
        <volume>43</volume>  
        <issue>5</issue>  
        <fpage>527</fpage>  
        <lpage>32</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/23079176"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1016/j.amepre.2012.07.019</pub-id>
        <pub-id pub-id-type="medline">23079176</pub-id>
        <pub-id pub-id-type="pii">S0749-3797(12)00520-X</pub-id>
        <pub-id pub-id-type="pmcid">PMC3479432</pub-id></nlm-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <nlm-citation citation-type="confproc">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>MacLean</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Gupta</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Lembke</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Manning</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Heer</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>An analysis of an online health forum dedicated to addiction recovery</article-title>
        <year>2015</year>  
        <conf-name>Proceedings of the 18th ACM Conference on Computer Supported Cooperative WorkSocial Computing</conf-name>
        <conf-date>March 14–18, 2015</conf-date>
        <conf-loc>Vancouver, BC, Canada</conf-loc>
        <publisher-loc>2675146</publisher-loc>
        <publisher-name>ACM</publisher-name>
        <pub-id pub-id-type="doi">10.1145/2675133.2675146</pub-id></nlm-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Han</surname>
            <given-names>JY</given-names>
          </name>
          <name name-style="western">
            <surname>Hou</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Kim</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Gustafson</surname>
            <given-names>DH</given-names>
          </name>
        </person-group>
        <article-title>Lurking as an active participation process: a longitudinal investigation of engagement with an online cancer support group</article-title>
        <source>Health Commun</source>  
        <year>2014</year>  
        <volume>29</volume>  
        <issue>9</issue>  
        <fpage>911</fpage>  
        <lpage>23</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/24345206"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1080/10410236.2013.816911</pub-id>
        <pub-id pub-id-type="medline">24345206</pub-id>
        <pub-id pub-id-type="pmcid">PMC4469645</pub-id></nlm-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Setoyama</surname>
            <given-names>Y</given-names>
          </name>
          <name name-style="western">
            <surname>Yamazaki</surname>
            <given-names>Y</given-names>
          </name>
          <name name-style="western">
            <surname>Namayama</surname>
            <given-names>K</given-names>
          </name>
        </person-group>
        <article-title>Benefits of peer support in online Japanese breast cancer communities: differences between lurkers and posters</article-title>
        <source>J Med Internet Res</source>  
        <year>2011</year>  
        <volume>13</volume>  
        <issue>4</issue>  
        <fpage>e122</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2011/4/e122/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.1696</pub-id>
        <pub-id pub-id-type="medline">22204869</pub-id>
        <pub-id pub-id-type="pii">v13i4e122</pub-id>
        <pub-id pub-id-type="pmcid">PMC3278108</pub-id></nlm-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Bull</surname>
            <given-names>SS</given-names>
          </name>
          <name name-style="western">
            <surname>Levine</surname>
            <given-names>DK</given-names>
          </name>
          <name name-style="western">
            <surname>Black</surname>
            <given-names>SR</given-names>
          </name>
          <name name-style="western">
            <surname>Schmiege</surname>
            <given-names>SJ</given-names>
          </name>
          <name name-style="western">
            <surname>Santelli</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>Social media-delivered sexual health intervention: a cluster randomized controlled trial</article-title>
        <source>Am J Prev Med</source>  
        <year>2012</year>  
        <month>11</month>  
        <volume>43</volume>  
        <issue>5</issue>  
        <fpage>467</fpage>  
        <lpage>74</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/23079168"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1016/j.amepre.2012.07.022</pub-id>
        <pub-id pub-id-type="medline">23079168</pub-id>
        <pub-id pub-id-type="pii">S0749-3797(12)00526-0</pub-id>
        <pub-id pub-id-type="pmcid">PMC3479665</pub-id></nlm-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Phua</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>Participating in health issue-specific social networking sites to quit smoking: how does online social interconnectedness influence smoking cessation self-efficacy?</article-title>
        <source>J Commun</source>  
        <year>2013</year>  
        <month>09</month>  
        <day>16</day>  
        <volume>63</volume>  
        <issue>5</issue>  
        <fpage>933</fpage>  
        <lpage>52</lpage>  
        <pub-id pub-id-type="doi">10.1111/jcom.12054</pub-id></nlm-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <nlm-citation citation-type="confproc">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Bazarova</surname>
            <given-names>N</given-names>
          </name>
          <name name-style="western">
            <surname>Choi</surname>
            <given-names>Y</given-names>
          </name>
          <name name-style="western">
            <surname>Sosik</surname>
            <given-names>V</given-names>
          </name>
          <name name-style="western">
            <surname>Cosley</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Whitlock</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>Social sharing of emotions on facebook: channel differences, satisfaction,replies</article-title>
        <year>2015</year>  
        <conf-name>Proceedings of the 18th ACM Conference on Computer Supported Cooperative Work &#38; Social Computing</conf-name>
        <conf-date>March 14-18, 2015</conf-date>
        <conf-loc>Vancouver, BC, Canada</conf-loc>
        <publisher-loc>2675297</publisher-loc>
        <publisher-name>ACM</publisher-name>
        <fpage>154</fpage>  
        <lpage>64</lpage> </nlm-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Zhao</surname>
            <given-names>X</given-names>
          </name>
          <name name-style="western">
            <surname>Cai</surname>
            <given-names>X</given-names>
          </name>
        </person-group>
        <article-title>The role of risk, efficacy, and anxiety in smokers' cancer information seeking</article-title>
        <source>Health Commun</source>  
        <year>2009</year>  
        <month>04</month>  
        <volume>24</volume>  
        <issue>3</issue>  
        <fpage>259</fpage>  
        <lpage>69</lpage>  
        <pub-id pub-id-type="doi">10.1080/10410230902805932</pub-id>
        <pub-id pub-id-type="medline">19415558</pub-id>
        <pub-id pub-id-type="pii">910939867</pub-id></nlm-citation>
      </ref>
      <ref id="ref13">
        <label>13</label>
        <nlm-citation citation-type="confproc">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Newman</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Lauterbach</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Munson</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Resnick</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Morris</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>i don't have problems, i'm just not putting them on facebook: challenges and opportunities in using online social networks for health</article-title>
        <year>2011</year>  
        <conf-name>It's not that Proceedings of the ACM 2011 conference on Computer Supported Cooperative Work</conf-name>
        <conf-date>March 19-23, 2011</conf-date>
        <conf-loc>Hangzhou, China</conf-loc>
        <publisher-loc>1958876</publisher-loc>
        <publisher-name>ACM</publisher-name>
        <fpage>341</fpage>  
        <lpage>50</lpage> </nlm-citation>
      </ref>
      <ref id="ref14">
        <label>14</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Lee</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Noh</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Koo</surname>
            <given-names>D</given-names>
          </name>
        </person-group>
        <article-title>Lonely people are no longer lonely on social networking sites: the mediating role of self-disclosure and social support</article-title>
        <source>Cyberpsychol Behav Soc Netw</source>  
        <year>2013</year>  
        <month>06</month>  
        <volume>16</volume>  
        <issue>6</issue>  
        <fpage>413</fpage>  
        <lpage>8</lpage>  
        <pub-id pub-id-type="doi">10.1089/cyber.2012.0553</pub-id>
        <pub-id pub-id-type="medline">23621716</pub-id></nlm-citation>
      </ref>
      <ref id="ref15">
        <label>15</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ellison</surname>
            <given-names>N</given-names>
          </name>
          <name name-style="western">
            <surname>Steinfield</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Lampe</surname>
            <given-names>C</given-names>
          </name>
        </person-group>
        <article-title>The benefits of facebook “Friends:” social capital and college students’ use of online social network sites</article-title>
        <source>J Comput Mediat Commun</source>  
        <year>2007</year>  
        <volume>12</volume>  
        <fpage>1143</fpage>  
        <lpage>68</lpage>  
        <pub-id pub-id-type="doi">10.1111/j.1083-6101.2007.00367.x</pub-id></nlm-citation>
      </ref>
      <ref id="ref16">
        <label>16</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Davis</surname>
            <given-names>MA</given-names>
          </name>
          <name name-style="western">
            <surname>Anthony</surname>
            <given-names>DL</given-names>
          </name>
          <name name-style="western">
            <surname>Pauls</surname>
            <given-names>SD</given-names>
          </name>
        </person-group>
        <article-title>Seeking and receiving social support on facebook for surgery</article-title>
        <source>Soc Sci Med</source>  
        <year>2015</year>  
        <month>04</month>  
        <volume>131</volume>  
        <fpage>40</fpage>  
        <lpage>7</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/25753284"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1016/j.socscimed.2015.02.038</pub-id>
        <pub-id pub-id-type="medline">25753284</pub-id>
        <pub-id pub-id-type="pii">S0277-9536(15)00130-6</pub-id>
        <pub-id pub-id-type="pmcid">PMC4380756</pub-id></nlm-citation>
      </ref>
      <ref id="ref17">
        <label>17</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Eysenbach</surname>
            <given-names>G</given-names>
          </name>
          <name name-style="western">
            <surname>Powell</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Englesakis</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Rizo</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Stern</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <article-title>Health related virtual communities and electronic support groups: systematic review of the effects of online peer to peer interactions</article-title>
        <source>BMJ</source>  
        <year>2004</year>  
        <month>05</month>  
        <day>15</day>  
        <volume>328</volume>  
        <issue>7449</issue>  
        <fpage>1166</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/15142921"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1136/bmj.328.7449.1166</pub-id>
        <pub-id pub-id-type="medline">15142921</pub-id>
        <pub-id pub-id-type="pii">328/7449/1166</pub-id>
        <pub-id pub-id-type="pmcid">PMC411092</pub-id></nlm-citation>
      </ref>
      <ref id="ref18">
        <label>18</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Shahab</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>McEwen</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <article-title>Online support for smoking cessation: a systematic review of the literature</article-title>
        <source>Addiction</source>  
        <year>2009</year>  
        <month>11</month>  
        <volume>104</volume>  
        <issue>11</issue>  
        <fpage>1792</fpage>  
        <lpage>804</lpage>  
        <pub-id pub-id-type="doi">10.1111/j.1360-0443.2009.02710.x</pub-id>
        <pub-id pub-id-type="medline">19832783</pub-id>
        <pub-id pub-id-type="pii">ADD2710</pub-id></nlm-citation>
      </ref>
      <ref id="ref19">
        <label>19</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Durkin</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Brennan</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Wakefield</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>Mass media campaigns to promote smoking cessation among adults: an integrative review</article-title>
        <source>Tob Control</source>  
        <year>2012</year>  
        <month>02</month>  
        <day>16</day>  
        <volume>21</volume>  
        <issue>2</issue>  
        <fpage>127</fpage>  
        <lpage>38</lpage>  
        <pub-id pub-id-type="doi">10.1136/tobaccocontrol-2011-050345</pub-id></nlm-citation>
      </ref>
      <ref id="ref20">
        <label>20</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Hughes</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Carpenter</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>The feasibility of smoking reduction: an update</article-title>
        <source>Addiction (Abingdon, England)</source>  
        <year>2005</year>  
        <volume>100</volume>  
        <issue>8</issue>  
        <fpage>1074</fpage>  
        <lpage>89</lpage>  
        <pub-id pub-id-type="pmcid">1419056</pub-id></nlm-citation>
      </ref>
      <ref id="ref21">
        <label>21</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Fishbein</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Cappella</surname>
            <given-names>JN</given-names>
          </name>
        </person-group>
        <article-title>The role of theory in developing effective health communications</article-title>
        <source>J Commun</source>  
        <year>2006</year>  
        <month>08</month>  
        <volume>56</volume>  
        <issue>s1</issue>  
        <fpage>S1</fpage>  
        <lpage>S17</lpage>  
        <pub-id pub-id-type="doi">10.1111/j.1460-2466.2006.00280.x</pub-id></nlm-citation>
      </ref>
      <ref id="ref22">
        <label>22</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Bandura</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <article-title>Health promotion from the perspective of social cognitive theory</article-title>
        <source>Psychol Health</source>  
        <year>1998</year>  
        <month>07</month>  
        <volume>13</volume>  
        <issue>4</issue>  
        <fpage>623</fpage>  
        <lpage>49</lpage>  
        <pub-id pub-id-type="doi">10.1080/08870449808407422</pub-id></nlm-citation>
      </ref>
      <ref id="ref23">
        <label>23</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Schooler</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Chaffee</surname>
            <given-names>SH</given-names>
          </name>
          <name name-style="western">
            <surname>Flora</surname>
            <given-names>JA</given-names>
          </name>
          <name name-style="western">
            <surname>Roser</surname>
            <given-names>C</given-names>
          </name>
        </person-group>
        <article-title>Health campaign channels tradeoffs among reach, specificity, and impact</article-title>
        <source>Human Comm Res</source>  
        <year>1998</year>  
        <month>03</month>  
        <volume>24</volume>  
        <issue>3</issue>  
        <fpage>410</fpage>  
        <lpage>32</lpage>  
        <pub-id pub-id-type="doi">10.1111/j.1468-2958.1998.tb00423.x</pub-id></nlm-citation>
      </ref>
      <ref id="ref24">
        <label>24</label>
        <nlm-citation citation-type="book">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Hornik</surname>
            <given-names>R</given-names>
          </name>
        </person-group>
        <person-group person-group-type="editor">
          <name name-style="western">
            <surname>Salmon</surname>
            <given-names>CT</given-names>
          </name>
        </person-group>
        <article-title>The knowledge-behavior gap in public information campaigns: a development communication view</article-title>
        <source>Information campaigns: Balancing social values and social change</source>  
        <year>1989</year>  
        <publisher-loc>Newbury Park, CA</publisher-loc>
        <publisher-name>Sage Publications</publisher-name></nlm-citation>
      </ref>
      <ref id="ref25">
        <label>25</label>
        <nlm-citation citation-type="confproc">
        <person-group person-group-type="author">
          <collab>Centers for Disease Control Prevention</collab>
        </person-group>
        <article-title>Best practices for comprehensive tobacco control programs</article-title>
        <source>U.S. Department of Health and Human Services, Centers for Disease Control and Prevention</source>  
        <year>2014</year>  
        <conf-name>National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health</conf-name>
        <conf-date>2014</conf-date>
        <conf-loc>Atlanta, GA</conf-loc></nlm-citation>
      </ref>
      <ref id="ref26">
        <label>26</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Gottlieb</surname>
            <given-names>BH</given-names>
          </name>
          <name name-style="western">
            <surname>Bergen</surname>
            <given-names>AE</given-names>
          </name>
        </person-group>
        <article-title>Social support concepts and measures</article-title>
        <source>J Psychosom Res</source>  
        <year>2010</year>  
        <month>11</month>  
        <volume>69</volume>  
        <issue>5</issue>  
        <fpage>511</fpage>  
        <lpage>20</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.jpsychores.2009.10.001</pub-id>
        <pub-id pub-id-type="medline">20955871</pub-id>
        <pub-id pub-id-type="pii">S0022-3999(09)00411-5</pub-id></nlm-citation>
      </ref>
      <ref id="ref27">
        <label>27</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Namkoong</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Shah</surname>
            <given-names>DV</given-names>
          </name>
          <name name-style="western">
            <surname>Gustafson</surname>
            <given-names>DH</given-names>
          </name>
        </person-group>
        <article-title>Offline social relationships and online cancer communication: effects of social and family support on online social network building</article-title>
        <source>Health Commun</source>  
        <year>2016</year>  
        <month>11</month>  
        <day>08</day>  
        <fpage>1</fpage>  
        <lpage>8</lpage>  
        <pub-id pub-id-type="doi">10.1080/10410236.2016.1230808</pub-id>
        <pub-id pub-id-type="medline">27824257</pub-id></nlm-citation>
      </ref>
      <ref id="ref28">
        <label>28</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Havassy</surname>
            <given-names>BE</given-names>
          </name>
          <name name-style="western">
            <surname>Hall</surname>
            <given-names>SM</given-names>
          </name>
          <name name-style="western">
            <surname>Wasserman</surname>
            <given-names>DA</given-names>
          </name>
        </person-group>
        <article-title>Social support and relapse: commonalities among alcoholics, opiate users, and cigarette smokers</article-title>
        <source>Addict Behav</source>  
        <year>1991</year>  
        <volume>16</volume>  
        <issue>5</issue>  
        <fpage>235</fpage>  
        <lpage>46</lpage>  
        <pub-id pub-id-type="medline">1663695</pub-id></nlm-citation>
      </ref>
      <ref id="ref29">
        <label>29</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ali</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Farrer</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>Gulliver</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Griffiths</surname>
            <given-names>KM</given-names>
          </name>
        </person-group>
        <article-title>Online peer-to-peer support for young people with mental health problems: a systematic review</article-title>
        <source>JMIR Ment Health</source>  
        <year>2015</year>  
        <volume>2</volume>  
        <issue>2</issue>  
        <fpage>e19</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://mental.jmir.org/2015/2/e19/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/mental.4418</pub-id>
        <pub-id pub-id-type="medline">26543923</pub-id>
        <pub-id pub-id-type="pii">v2i2e19</pub-id>
        <pub-id pub-id-type="pmcid">PMC4607385</pub-id></nlm-citation>
      </ref>
      <ref id="ref30">
        <label>30</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Fox</surname>
            <given-names>S</given-names>
          </name>
        </person-group>
        <source>Pew Research Center</source>  
        <year>2011</year>  
        <access-date>2017-05-02</access-date>
        <comment>Peer-to-peer health care 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.pewinternet.org/2011/02/28/peer-to-peer-health-care-2/">http://www.pewinternet.org/2011/02/28/peer-to-peer-health-care-2/</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6qANEwqa7"/></comment> </nlm-citation>
      </ref>
      <ref id="ref31">
        <label>31</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Pagoto</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Waring</surname>
            <given-names>ME</given-names>
          </name>
          <name name-style="western">
            <surname>May</surname>
            <given-names>CN</given-names>
          </name>
          <name name-style="western">
            <surname>Ding</surname>
            <given-names>EY</given-names>
          </name>
          <name name-style="western">
            <surname>Kunz</surname>
            <given-names>WH</given-names>
          </name>
          <name name-style="western">
            <surname>Hayes</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Oleski</surname>
            <given-names>JL</given-names>
          </name>
        </person-group>
        <article-title>Adapting behavioral interventions for social media delivery</article-title>
        <source>J Med Internet Res</source>  
        <year>2016</year>  
        <volume>18</volume>  
        <issue>1</issue>  
        <fpage>e24</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2016/1/e24/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.5086</pub-id>
        <pub-id pub-id-type="medline">26825969</pub-id>
        <pub-id pub-id-type="pii">v18i1e24</pub-id>
        <pub-id pub-id-type="pmcid">PMC4752690</pub-id></nlm-citation>
      </ref>
      <ref id="ref32">
        <label>32</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Warren</surname>
            <given-names>JI</given-names>
          </name>
          <name name-style="western">
            <surname>Stein</surname>
            <given-names>JA</given-names>
          </name>
          <name name-style="western">
            <surname>Grella</surname>
            <given-names>CE</given-names>
          </name>
        </person-group>
        <article-title>Role of social support and self-efficacy in treatment outcomes among clients with co-occurring disorders</article-title>
        <source>Drug Alcohol Depend</source>  
        <year>2007</year>  
        <month>07</month>  
        <day>10</day>  
        <volume>89</volume>  
        <issue>2-3</issue>  
        <fpage>267</fpage>  
        <lpage>74</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/17329040"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1016/j.drugalcdep.2007.01.009</pub-id>
        <pub-id pub-id-type="medline">17329040</pub-id>
        <pub-id pub-id-type="pii">S0376-8716(07)00045-2</pub-id>
        <pub-id pub-id-type="pmcid">PMC2753536</pub-id></nlm-citation>
      </ref>
      <ref id="ref33">
        <label>33</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Neuling</surname>
            <given-names>SJ</given-names>
          </name>
          <name name-style="western">
            <surname>Winefield</surname>
            <given-names>HR</given-names>
          </name>
        </person-group>
        <article-title>Social support and recovery after surgery for breast cancer: frequency and correlates of supportive behaviours by family, friends and surgeon</article-title>
        <source>Soc Sci Med</source>  
        <year>1988</year>  
        <volume>27</volume>  
        <issue>4</issue>  
        <fpage>385</fpage>  
        <lpage>92</lpage>  
        <pub-id pub-id-type="medline">3175721</pub-id></nlm-citation>
      </ref>
      <ref id="ref34">
        <label>34</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Mason</surname>
            <given-names>W</given-names>
          </name>
          <name name-style="western">
            <surname>Suri</surname>
            <given-names>S</given-names>
          </name>
        </person-group>
        <article-title>Conducting behavioral research on Amazon's mechanical turk</article-title>
        <source>Behav Res Methods</source>  
        <year>2012</year>  
        <month>03</month>  
        <volume>44</volume>  
        <issue>1</issue>  
        <fpage>1</fpage>  
        <lpage>23</lpage>  
        <pub-id pub-id-type="doi">10.3758/s13428-011-0124-6</pub-id>
        <pub-id pub-id-type="medline">21717266</pub-id></nlm-citation>
      </ref>
      <ref id="ref35">
        <label>35</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Buhrmester</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Kwang</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Gosling</surname>
            <given-names>SD</given-names>
          </name>
        </person-group>
        <article-title>Amazon's mechanical turk: a new source of inexpensive, yet high-quality, data?</article-title>
        <source>Perspect Psychol Sci</source>  
        <year>2011</year>  
        <month>02</month>  
        <day>03</day>  
        <volume>6</volume>  
        <issue>1</issue>  
        <fpage>3</fpage>  
        <lpage>5</lpage>  
        <pub-id pub-id-type="doi">10.1177/1745691610393980</pub-id></nlm-citation>
      </ref>
      <ref id="ref36">
        <label>36</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Kim</surname>
            <given-names>SJ</given-names>
          </name>
          <name name-style="western">
            <surname>Hancock</surname>
            <given-names>JT</given-names>
          </name>
        </person-group>
        <article-title>How advertorials deactivate advertising schema: MTurk-based experiments to examine persuasion tactics and outcomes in health advertisements</article-title>
        <source>‎Comm Res</source>  
        <year>2016</year>  
        <month>04</month>  
        <day>25</day>  
        <fpage>-</fpage>  
        <comment>Epub ahead of print</comment>  
        <pub-id pub-id-type="doi">10.1177/0093650216644017</pub-id></nlm-citation>
      </ref>
      <ref id="ref37">
        <label>37</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Yu</surname>
            <given-names>B</given-names>
          </name>
          <name name-style="western">
            <surname>Willis</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Sun</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Wang</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>Crowdsourcing participatory evaluation of medical pictograms using Amazon mechanical turk</article-title>
        <source>J Med Internet Res</source>  
        <year>2013</year>  
        <volume>15</volume>  
        <issue>6</issue>  
        <fpage>e108</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2013/6/e108/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.2513</pub-id>
        <pub-id pub-id-type="medline">23732572</pub-id>
        <pub-id pub-id-type="pii">v15i6e108</pub-id>
        <pub-id pub-id-type="pmcid">PMC3785992</pub-id></nlm-citation>
      </ref>
      <ref id="ref38">
        <label>38</label>
        <nlm-citation citation-type="confproc">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Snow</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>O'Connor</surname>
            <given-names>B</given-names>
          </name>
          <name name-style="western">
            <surname>Jurafsky</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Ng</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <article-title>Cheap and fast---but is it good? evaluating non-expert annotations for natural language tasks</article-title>
        <year>2008</year>  
        <conf-name>Proceedings of the Conference on Empirical Methods in Natural Language Processing</conf-name>
        <conf-date>October 25-27, 2008</conf-date>
        <conf-loc>Honolulu, HI</conf-loc>
        <publisher-loc>1613751</publisher-loc>
        <publisher-name>Association for Computational Linguistics</publisher-name>
        <fpage>254</fpage>  
        <lpage>63</lpage> </nlm-citation>
      </ref>
      <ref id="ref39">
        <label>39</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Wilson</surname>
            <given-names>DK</given-names>
          </name>
          <name name-style="western">
            <surname>Wallston</surname>
            <given-names>KA</given-names>
          </name>
          <name name-style="western">
            <surname>King</surname>
            <given-names>JE</given-names>
          </name>
        </person-group>
        <article-title>Effects of contract framing, motivation to quit, and self-efficacy on smoking reduction</article-title>
        <source>J Appl Social Pyschol</source>  
        <year>1990</year>  
        <month>04</month>  
        <volume>20</volume>  
        <issue>7</issue>  
        <fpage>531</fpage>  
        <lpage>47</lpage>  
        <pub-id pub-id-type="doi">10.1111/j.1559-1816.1990.tb00426.x</pub-id></nlm-citation>
      </ref>
      <ref id="ref40">
        <label>40</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Sterling</surname>
            <given-names>KL</given-names>
          </name>
          <name name-style="western">
            <surname>Diamond</surname>
            <given-names>PM</given-names>
          </name>
          <name name-style="western">
            <surname>Mullen</surname>
            <given-names>PD</given-names>
          </name>
          <name name-style="western">
            <surname>Pallonen</surname>
            <given-names>U</given-names>
          </name>
          <name name-style="western">
            <surname>Ford</surname>
            <given-names>KH</given-names>
          </name>
          <name name-style="western">
            <surname>McAlister</surname>
            <given-names>AL</given-names>
          </name>
        </person-group>
        <article-title>Smoking-related self-efficacy, beliefs, and intention: assessing factorial validity and structural relationships in 9 th–12th grade current smokers in Texas</article-title>
        <source>Addict Behav</source>  
        <year>2007</year>  
        <volume>32</volume>  
        <issue>9</issue>  
        <fpage>1863</fpage>  
        <lpage>76</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.addbeh.2006.12.018</pub-id>
        <pub-id pub-id-type="pmcid">PMC2093963</pub-id></nlm-citation>
      </ref>
      <ref id="ref41">
        <label>41</label>
        <nlm-citation citation-type="web">
        <source>Maryland Resource Center</source>  
        <access-date>2017-01-11</access-date>
        <comment>The A3C clinical model 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://mdquit.org/fax-to-assist/module-2">http://mdquit.org/fax-to-assist/module-2</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6nRaFo6X7"/></comment> </nlm-citation>
      </ref>
      <ref id="ref42">
        <label>42</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Norman</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Conner</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Bell</surname>
            <given-names>R</given-names>
          </name>
        </person-group>
        <article-title>The theory of planned behavior and smoking cessation</article-title>
        <source>Health Psychol</source>  
        <year>1999</year>  
        <month>01</month>  
        <volume>18</volume>  
        <issue>1</issue>  
        <fpage>89</fpage>  
        <lpage>94</lpage>  
        <pub-id pub-id-type="medline">9925050</pub-id></nlm-citation>
      </ref>
      <ref id="ref43">
        <label>43</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Douglas</surname>
            <given-names>KA</given-names>
          </name>
          <name name-style="western">
            <surname>Collins</surname>
            <given-names>JL</given-names>
          </name>
          <name name-style="western">
            <surname>Warren</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Kann</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>Gold</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Clayton</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Ross</surname>
            <given-names>JG</given-names>
          </name>
          <name name-style="western">
            <surname>Kolbe</surname>
            <given-names>LJ</given-names>
          </name>
        </person-group>
        <article-title>Results from the 1995 National College Health Risk Behavior Survey</article-title>
        <source>J Am Coll Health</source>  
        <year>1997</year>  
        <month>09</month>  
        <volume>46</volume>  
        <issue>2</issue>  
        <fpage>55</fpage>  
        <lpage>66</lpage>  
        <pub-id pub-id-type="doi">10.1080/07448489709595589</pub-id>
        <pub-id pub-id-type="medline">9276349</pub-id></nlm-citation>
      </ref>
      <ref id="ref44">
        <label>44</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Kim</surname>
            <given-names>SJ</given-names>
          </name>
          <name name-style="western">
            <surname>Niederdeppe</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>Emotional expressions in antismoking television advertisements: consequences of anger and sadness framing on pathways to persuasion</article-title>
        <source>J Health Commun</source>  
        <year>2014</year>  
        <volume>19</volume>  
        <issue>6</issue>  
        <fpage>692</fpage>  
        <lpage>709</lpage>  
        <pub-id pub-id-type="doi">10.1080/10810730.2013.837550</pub-id>
        <pub-id pub-id-type="medline">24417482</pub-id></nlm-citation>
      </ref>
      <ref id="ref45">
        <label>45</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Chung</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Maisto</surname>
            <given-names>SA</given-names>
          </name>
          <name name-style="western">
            <surname>Mihalo</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Martin</surname>
            <given-names>CS</given-names>
          </name>
          <name name-style="western">
            <surname>Cornelius</surname>
            <given-names>JR</given-names>
          </name>
          <name name-style="western">
            <surname>Clark</surname>
            <given-names>DB</given-names>
          </name>
        </person-group>
        <article-title>Brief assessment of readiness to change tobacco use in treated youth</article-title>
        <source>J Subst Abuse Treat</source>  
        <year>2011</year>  
        <month>09</month>  
        <volume>41</volume>  
        <issue>2</issue>  
        <fpage>137</fpage>  
        <lpage>47</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/21489740"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1016/j.jsat.2011.02.010</pub-id>
        <pub-id pub-id-type="pii">S0740-5472(11)00053-5</pub-id>
        <pub-id pub-id-type="pmcid">PMC3137741</pub-id></nlm-citation>
      </ref>
      <ref id="ref46">
        <label>46</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
        <name name-style="western">
        <surname>Wei</surname> 
        <given-names>R</given-names></name> 
        <name name-style="western">
        <surname>Lo</surname> 
        <given-names>V</given-names></name> 
        <name name-style="western">
        <surname>Lu</surname> 
        <given-names>H</given-names></name> </person-group>
        <article-title>Reconsidering the relationship between the third-person perception and optimistic bias</article-title>
        <source>‎Comm Res</source> 
        <year>2007</year> 
        <month>12</month> 
        <day>01</day> 
        <volume>34</volume> 
        <issue>6</issue> 
        <fpage>665</fpage> 
        <lpage>84</lpage> 
        <pub-id pub-id-type="doi">10.1177/0093650207307903</pub-id></nlm-citation>
      </ref>
      <ref id="ref47">
        <label>47</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Wright</surname>
            <given-names>KB</given-names>
          </name>
          <name name-style="western">
            <surname>Rosenberg</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Egbert</surname>
            <given-names>N</given-names>
          </name>
          <name name-style="western">
            <surname>Ploeger</surname>
            <given-names>NA</given-names>
          </name>
          <name name-style="western">
            <surname>Bernard</surname>
            <given-names>DR</given-names>
          </name>
          <name name-style="western">
            <surname>King</surname>
            <given-names>S</given-names>
          </name>
        </person-group>
        <article-title>Communication competence, social support, and depression among college students: a model of facebook and face-to-face support network influence</article-title>
        <source>J Health Commun</source>  
        <year>2013</year>  
        <volume>18</volume>  
        <issue>1</issue>  
        <fpage>41</fpage>  
        <lpage>57</lpage>  
        <pub-id pub-id-type="doi">10.1080/10810730.2012.688250</pub-id>
        <pub-id pub-id-type="medline">23030518</pub-id></nlm-citation>
      </ref>
      <ref id="ref48">
        <label>48</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Lund</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <source>STC Usability SIG Newsletter</source>  
        <year>2000</year>  
        <access-date>2017-05-02</access-date>
        <comment>Measuring usability with the USE questionnaire 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.stcsig.org/usability/newsletter/index.html">http://www.stcsig.org/usability/newsletter/index.html</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6qAQFwDvc"/></comment> </nlm-citation>
      </ref>
      <ref id="ref49">
        <label>49</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Lewis</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>IBM computer usability satisfaction questionnaires: psychometric evaluation and instructions for use</article-title>
        <source>Int J Hum Comput Interact</source>  
        <year>1995</year>  
        <month>01</month>  
        <volume>7</volume>  
        <issue>1</issue>  
        <fpage>57</fpage>  
        <lpage>78</lpage>  
        <pub-id pub-id-type="doi">10.1080/10447319509526110</pub-id></nlm-citation>
      </ref>
      <ref id="ref50">
        <label>50</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ben-Zeev</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Brenner</surname>
            <given-names>CJ</given-names>
          </name>
          <name name-style="western">
            <surname>Begale</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Duffecy</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Mohr</surname>
            <given-names>DC</given-names>
          </name>
          <name name-style="western">
            <surname>Mueser</surname>
            <given-names>KT</given-names>
          </name>
        </person-group>
        <article-title>Feasibility, acceptability, and preliminary efficacy of a smartphone intervention for schizophrenia</article-title>
        <source>Schizophr Bull</source>  
        <year>2014</year>  
        <month>11</month>  
        <volume>40</volume>  
        <issue>6</issue>  
        <fpage>1244</fpage>  
        <lpage>53</lpage>  
        <pub-id pub-id-type="doi">10.1093/schbul/sbu033</pub-id>
        <pub-id pub-id-type="medline">24609454</pub-id>
        <pub-id pub-id-type="pii">sbu033</pub-id>
        <pub-id pub-id-type="pmcid">PMC4193714</pub-id></nlm-citation>
      </ref>
      <ref id="ref51">
        <label>51</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <collab>R Core Team</collab>
        </person-group>
        <source>R-project</source>  
        <year>2016</year>  
        <access-date>2017-05-02</access-date>
        <publisher-loc>Vienna, Austria</publisher-loc>
        <comment>R: A language and environment for statistical computing 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.R-project.org">http://www.R-project.org</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6qAQYB5kB"/></comment> </nlm-citation>
      </ref>
      <ref id="ref52">
        <label>52</label>
        <nlm-citation citation-type="web">
        <source>IBM</source>  
        <year>2013</year>  
        <access-date>2017-05-02</access-date>
        <comment>IBM SPSS Statistics for Windows 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://www.ibm.com/us-en/">https://www.ibm.com/us-en/</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6qAQimBxs"/></comment> </nlm-citation>
      </ref>
      <ref id="ref53">
        <label>53</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ramo</surname>
            <given-names>DE</given-names>
          </name>
          <name name-style="western">
            <surname>Thrul</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Chavez</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Delucchi</surname>
            <given-names>KL</given-names>
          </name>
          <name name-style="western">
            <surname>Prochaska</surname>
            <given-names>JJ</given-names>
          </name>
        </person-group>
        <article-title>Feasibility and quit rates of the tobacco status project: a facebook smoking cessation intervention for young adults</article-title>
        <source>J Med Internet Res</source>  
        <year>2015</year>  
        <volume>17</volume>  
        <issue>12</issue>  
        <fpage>e291</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2015/12/e291/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.5209</pub-id>
        <pub-id pub-id-type="medline">26721211</pub-id>
        <pub-id pub-id-type="pii">v17i12e291</pub-id>
        <pub-id pub-id-type="pmcid">PMC4736286</pub-id></nlm-citation>
      </ref>
      <ref id="ref54">
        <label>54</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Stead</surname>
            <given-names>LF</given-names>
          </name>
          <name name-style="western">
            <surname>Lancaster</surname>
            <given-names>T</given-names>
          </name>
        </person-group>
        <article-title>Interventions to reduce harm from continued tobacco use</article-title>
        <source>Cochrane Database Syst Rev</source>  
        <year>2007</year>  
        <month>07</month>  
        <day>18</day>  
        <issue>3</issue>  
        <fpage>CD005231</fpage>  
        <pub-id pub-id-type="doi">10.1002/14651858.CD005231.pub2</pub-id>
        <pub-id pub-id-type="medline">17636791</pub-id></nlm-citation>
      </ref>
      <ref id="ref55">
        <label>55</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Bjartveit</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Tverdal</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <article-title>Health consequences of smoking 1-4 cigarettes per day</article-title>
        <source>Tob Control</source>  
        <year>2005</year>  
        <month>10</month>  
        <volume>14</volume>  
        <issue>5</issue>  
        <fpage>315</fpage>  
        <lpage>20</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://tobaccocontrol.bmj.com/cgi/pmidlookup?view=long&#38;pmid=16183982"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1136/tc.2005.011932</pub-id>
        <pub-id pub-id-type="medline">16183982</pub-id>
        <pub-id pub-id-type="pii">14/5/315</pub-id>
        <pub-id pub-id-type="pmcid">PMC1748107</pub-id></nlm-citation>
      </ref>
      <ref id="ref56">
        <label>56</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Wennike</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Danielsson</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Landfeldt</surname>
            <given-names>B</given-names>
          </name>
          <name name-style="western">
            <surname>Westin</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Tønnesen</surname>
            <given-names>Philip</given-names>
          </name>
        </person-group>
        <article-title>Smoking reduction promotes smoking cessation: results from a double blind, randomized, placebo-controlled trial of nicotine gum with 2-year follow-up</article-title>
        <source>Addiction</source>  
        <year>2003</year>  
        <month>10</month>  
        <volume>98</volume>  
        <issue>10</issue>  
        <fpage>1395</fpage>  
        <lpage>402</lpage>  
        <pub-id pub-id-type="medline">14519176</pub-id>
        <pub-id pub-id-type="pii">489</pub-id></nlm-citation>
      </ref>
      <ref id="ref57">
        <label>57</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Vangeli</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Stapleton</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Smit</surname>
            <given-names>ES</given-names>
          </name>
          <name name-style="western">
            <surname>Borland</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>West</surname>
            <given-names>R</given-names>
          </name>
        </person-group>
        <article-title>Predictors of attempts to stop smoking and their success in adult general population samples: a systematic review</article-title>
        <source>Addiction</source>  
        <year>2011</year>  
        <month>12</month>  
        <volume>106</volume>  
        <issue>12</issue>  
        <fpage>2110</fpage>  
        <lpage>21</lpage>  
        <pub-id pub-id-type="doi">10.1111/j.1360-0443.2011.03565.x</pub-id>
        <pub-id pub-id-type="medline">21752135</pub-id></nlm-citation>
      </ref>
      <ref id="ref58">
        <label>58</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Godtfredsen</surname>
            <given-names>NS</given-names>
          </name>
          <name name-style="western">
            <surname>Prescott</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Osler</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>Effect of smoking reduction on lung cancer risk</article-title>
        <source>JAMA</source>  
        <year>2005</year>  
        <month>09</month>  
        <day>28</day>  
        <volume>294</volume>  
        <issue>12</issue>  
        <fpage>1505</fpage>  
        <lpage>10</lpage>  
        <pub-id pub-id-type="doi">10.1001/jama.294.12.1505</pub-id>
        <pub-id pub-id-type="medline">16189363</pub-id>
        <pub-id pub-id-type="pii">294/12/1505</pub-id></nlm-citation>
      </ref>
      <ref id="ref59">
        <label>59</label>
        <nlm-citation citation-type="web">
        <source>Facebook</source>  
        <year>2017</year>  
        <access-date>2017-05-02</access-date>
        <comment>How is engagement rate defined? 
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://www.facebook.com/help/178043462360087">https://www.facebook.com/help/178043462360087</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6qAR6gppN"/></comment> </nlm-citation>
      </ref>
      <ref id="ref60">
        <label>60</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Bazarova</surname>
            <given-names>NN</given-names>
          </name>
          <name name-style="western">
            <surname>Choi</surname>
            <given-names>YH</given-names>
          </name>
        </person-group>
        <article-title>Self-disclosure in social media: extending the functional approach to disclosure motivations and characteristics on social network sites</article-title>
        <source>J Commun</source>  
        <year>2014</year>  
        <month>06</month>  
        <day>19</day>  
        <volume>64</volume>  
        <issue>4</issue>  
        <fpage>635</fpage>  
        <lpage>57</lpage>  
        <pub-id pub-id-type="doi">10.1111/jcom.12106</pub-id></nlm-citation>
      </ref>
      <ref id="ref61">
        <label>61</label>
        <nlm-citation citation-type="book">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Nunnally</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <source>Psychometric theory</source>  
        <year>1978</year>  
        <publisher-loc>New York</publisher-loc>
        <publisher-name>McGraw-Hill</publisher-name></nlm-citation>
      </ref>
      <ref id="ref62">
        <label>62</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Thrul</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Klein</surname>
            <given-names>AB</given-names>
          </name>
          <name name-style="western">
            <surname>Ramo</surname>
            <given-names>DE</given-names>
          </name>
        </person-group>
        <article-title>Smoking cessation intervention on facebook: which content generates the best engagement?</article-title>
        <source>J Med Internet Res</source>  
        <year>2015</year>  
        <volume>17</volume>  
        <issue>11</issue>  
        <fpage>e244</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2015/11/e244/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.4575</pub-id>
        <pub-id pub-id-type="medline">26561529</pub-id>
        <pub-id pub-id-type="pii">v17i11e244</pub-id>
        <pub-id pub-id-type="pmcid">PMC4704894</pub-id></nlm-citation>
      </ref>
      <ref id="ref63">
        <label>63</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>van Uden-Kraan</surname>
            <given-names>CF</given-names>
          </name>
          <name name-style="western">
            <surname>Drossaert</surname>
            <given-names>CH</given-names>
          </name>
          <name name-style="western">
            <surname>Taal</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Seydel</surname>
            <given-names>ER</given-names>
          </name>
          <name name-style="western">
            <surname>van de Laar</surname>
            <given-names>MA</given-names>
          </name>
        </person-group>
        <article-title>Self-reported differences in empowerment between lurkers and posters in online patient support groups</article-title>
        <source>J Med Internet Res</source>  
        <year>2008</year>  
        <month>06</month>  
        <day>30</day>  
        <volume>10</volume>  
        <issue>2</issue>  
        <fpage>e18</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2008/2/e18/"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2196/jmir.992</pub-id>
        <pub-id pub-id-type="medline">18653442</pub-id>
        <pub-id pub-id-type="pii">v10i2e18</pub-id>
        <pub-id pub-id-type="pmcid">PMC2483925</pub-id></nlm-citation>
      </ref>
      <ref id="ref64">
        <label>64</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Han</surname>
            <given-names>JY</given-names>
          </name>
          <name name-style="western">
            <surname>Hou</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Kim</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Gustafson</surname>
            <given-names>DH</given-names>
          </name>
        </person-group>
        <article-title>Lurking as an active participation process: a longitudinal investigation of engagement with an online cancer support group</article-title>
        <source>Health Commun</source>  
        <year>2014</year>  
        <volume>29</volume>  
        <issue>9</issue>  
        <fpage>911</fpage>  
        <lpage>23</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/24345206"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1080/10410236.2013.816911</pub-id>
        <pub-id pub-id-type="medline">24345206</pub-id>
        <pub-id pub-id-type="pmcid">PMC4469645</pub-id></nlm-citation>
      </ref>
      <ref id="ref65">
        <label>65</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Kim</surname>
            <given-names>SJ</given-names>
          </name>
          <name name-style="western">
            <surname>Marsch</surname>
            <given-names>LA</given-names>
          </name>
          <name name-style="western">
            <surname>Guarino</surname>
            <given-names>H</given-names>
          </name>
          <name name-style="western">
            <surname>Acosta</surname>
            <given-names>MC</given-names>
          </name>
          <name name-style="western">
            <surname>Aponte-Melendez</surname>
            <given-names>Y</given-names>
          </name>
        </person-group>
        <article-title>Predictors of outcome from computer-based treatment for substance use disorders: Results from a randomized clinical trial</article-title>
        <source>Drug Alcohol Depend</source>  
        <year>2015</year>  
        <volume>157</volume>  
        <fpage>174</fpage>  
        <lpage>8</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.drugalcdep.2015.09.019</pub-id></nlm-citation>
      </ref>
      <ref id="ref66">
        <label>66</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Leventhal</surname>
            <given-names>H</given-names>
          </name>
          <name name-style="western">
            <surname>Leventhal</surname>
            <given-names>EA</given-names>
          </name>
          <name name-style="western">
            <surname>Contrada</surname>
            <given-names>RJ</given-names>
          </name>
        </person-group>
        <article-title>Self-regulation, health, and behavior: a perceptual-cognitive approach</article-title>
        <source>Psychol Health</source>  
        <year>1998</year>  
        <month>07</month>  
        <volume>13</volume>  
        <issue>4</issue>  
        <fpage>717</fpage>  
        <lpage>33</lpage>  
        <pub-id pub-id-type="doi">10.1080/08870449808407425</pub-id></nlm-citation>
      </ref>
      <ref id="ref67">
        <label>67</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Fishbein</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Yzer</surname>
            <given-names>MC</given-names>
          </name>
        </person-group>
        <article-title>Using theory to design effective health behavior interventions</article-title>
        <source>Commun Theory</source>  
        <year>2003</year>  
        <month>05</month>  
        <volume>13</volume>  
        <issue>2</issue>  
        <fpage>164</fpage>  
        <lpage>83</lpage>  
        <pub-id pub-id-type="doi">10.1111/j.1468-2885.2003.tb00287.x</pub-id></nlm-citation>
      </ref>
      <ref id="ref68">
        <label>68</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Valle</surname>
            <given-names>CG</given-names>
          </name>
          <name name-style="western">
            <surname>Tate</surname>
            <given-names>DF</given-names>
          </name>
          <name name-style="western">
            <surname>Mayer</surname>
            <given-names>DK</given-names>
          </name>
          <name name-style="western">
            <surname>Allicock</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Cai</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>A randomized trial of a facebook-based physical activity intervention for young adult cancer survivors</article-title>
        <source>J Cancer Surviv</source>  
        <year>2013</year>  
        <month>09</month>  
        <volume>7</volume>  
        <issue>3</issue>  
        <fpage>355</fpage>  
        <lpage>68</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/23532799"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1007/s11764-013-0279-5</pub-id>
        <pub-id pub-id-type="medline">23532799</pub-id>
        <pub-id pub-id-type="pmcid">PMC3737370</pub-id></nlm-citation>
      </ref>
      <ref id="ref69">
        <label>69</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
        <name name-style="western">
        <surname>Lee</surname> 
        <given-names>E-J</given-names></name> 
        <name name-style="western">
        <surname>Kim</surname> 
        <given-names>YW</given-names></name> </person-group>
        <article-title>Effects of infographics on news elaboration, acquisition, and evaluation: prior knowledge and issue involvement as moderators</article-title>
        <source>‎New Media &#38; Soc</source> 
        <year>2015</year> 
        <month>01</month> 
        <day>14</day> 
        <volume>18</volume> 
        <issue>8</issue> 
        <fpage>1579</fpage> 
        <lpage>98</lpage> 
        <pub-id pub-id-type="doi">10.1177/1461444814567982</pub-id></nlm-citation>
      </ref>
      <ref id="ref70">
        <label>70</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Dallery</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Raiff</surname>
            <given-names>BR</given-names>
          </name>
          <name name-style="western">
            <surname>Kim</surname>
            <given-names>SJ</given-names>
          </name>
          <name name-style="western">
            <surname>Marsch</surname>
            <given-names>LA</given-names>
          </name>
          <name name-style="western">
            <surname>Stitzer</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Grabinski</surname>
            <given-names>MJ</given-names>
          </name>
        </person-group>
        <article-title>Nationwide access to an internet-based contingency management intervention to promote smoking cessation: a randomized controlled trial</article-title>
        <source>Addiction</source>  
        <year>2016</year>  
        <month>12</month>  
        <day>06</day>  
        <volume>112</volume>  
        <issue>5</issue>  
        <fpage>875</fpage>  
        <lpage>83</lpage>  
        <pub-id pub-id-type="doi">10.1111/add.13715</pub-id>
        <pub-id pub-id-type="medline">27923264</pub-id></nlm-citation>
      </ref>
      <ref id="ref71">
        <label>71</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ajzen</surname>
            <given-names>I</given-names>
          </name>
          <name name-style="western">
            <surname>Fishbein</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>Attitude-behavior relations: a theoretical analysis and review of empirical research</article-title>
        <source>Psychol Bull</source>  
        <year>1977</year>  
        <volume>84</volume>  
        <issue>5</issue>  
        <fpage>888</fpage>  
        <lpage>918</lpage>  
        <pub-id pub-id-type="doi">10.1037/0033-2909.84.5.888</pub-id></nlm-citation>
      </ref>
      <ref id="ref72">
        <label>72</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Fishbein</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Yzer</surname>
            <given-names>MC</given-names>
          </name>
        </person-group>
        <article-title>Using theory to design effective health behavior interventions</article-title>
        <source>Commun Theory</source>  
        <year>2003</year>  
        <month>05</month>  
        <volume>13</volume>  
        <issue>2</issue>  
        <fpage>164</fpage>  
        <lpage>83</lpage>  
        <pub-id pub-id-type="doi">10.1111/j.1468-2885.2003.tb00287.x</pub-id></nlm-citation>
      </ref>
      <ref id="ref73">
        <label>73</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Cobb</surname>
            <given-names>NK</given-names>
          </name>
          <name name-style="western">
            <surname>Jacobs</surname>
            <given-names>MA</given-names>
          </name>
          <name name-style="western">
            <surname>Wileyto</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Valente</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Graham</surname>
            <given-names>AL</given-names>
          </name>
        </person-group>
        <article-title>Diffusion of an evidence-based smoking cessation intervention through facebook: a randomized controlled trial</article-title>
        <source>Am J Public Health</source>  
        <year>2016</year>  
        <month>06</month>  
        <volume>106</volume>  
        <issue>6</issue>  
        <fpage>1130</fpage>  
        <lpage>5</lpage>  
        <pub-id pub-id-type="doi">10.2105/AJPH.2016.303106</pub-id>
        <pub-id pub-id-type="medline">27077358</pub-id>
        <pub-id pub-id-type="pmcid">PMC4880261</pub-id></nlm-citation>
      </ref>
      <ref id="ref74">
        <label>74</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Williams</surname>
            <given-names>G</given-names>
          </name>
          <name name-style="western">
            <surname>Hamm</surname>
            <given-names>MP</given-names>
          </name>
          <name name-style="western">
            <surname>Shulhan</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Vandermeer</surname>
            <given-names>B</given-names>
          </name>
          <name name-style="western">
            <surname>Hartling</surname>
            <given-names>L</given-names>
          </name>
        </person-group>
        <article-title>Social media interventions for diet and exercise behaviours: a systematic review and meta-analysis of randomised controlled trials</article-title>
        <source>BMJ Open</source>  
        <year>2014</year>  
        <volume>4</volume>  
        <issue>2</issue>  
        <fpage>e003926</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://bmjopen.bmj.com/cgi/pmidlookup?view=long&#38;pmid=24525388"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1136/bmjopen-2013-003926</pub-id>
        <pub-id pub-id-type="medline">24525388</pub-id>
        <pub-id pub-id-type="pii">bmjopen-2013-003926</pub-id>
        <pub-id pub-id-type="pmcid">PMC3927930</pub-id></nlm-citation>
      </ref>
      <ref id="ref75">
        <label>75</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Nguyen</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Gold</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Pedrana</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Chang</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Howard</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Ilic</surname>
            <given-names>O</given-names>
          </name>
          <name name-style="western">
            <surname>Hellard</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Stoove</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>Sexual health promotion on social networking sites: a process evaluation of The FaceSpace Project</article-title>
        <source>J Adolesc Health</source>  
        <year>2013</year>  
        <month>07</month>  
        <volume>53</volume>  
        <issue>1</issue>  
        <fpage>98</fpage>  
        <lpage>104</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.jadohealth.2013.02.007</pub-id>
        <pub-id pub-id-type="medline">23583509</pub-id>
        <pub-id pub-id-type="pii">S1054-139X(13)00084-0</pub-id></nlm-citation>
      </ref>
      <ref id="ref76">
        <label>76</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Kim</surname>
            <given-names>SJ</given-names>
          </name>
          <name name-style="western">
            <surname>Hancock</surname>
            <given-names>JT</given-names>
          </name>
        </person-group>
        <article-title>Optimistic bias and Facebook use: self-other discrepancies about potential risks and benefits of facebook use</article-title>
        <source>Cyberpsychol Behav Soc Netw</source>  
        <year>2015</year>  
        <month>04</month>  
        <volume>18</volume>  
        <issue>4</issue>  
        <fpage>214</fpage>  
        <lpage>20</lpage>  
        <pub-id pub-id-type="doi">10.1089/cyber.2014.0656</pub-id>
        <pub-id pub-id-type="medline">25879379</pub-id></nlm-citation>
      </ref>
      <ref id="ref77">
        <label>77</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Toma</surname>
            <given-names>CL</given-names>
          </name>
          <name name-style="western">
            <surname>Hancock</surname>
            <given-names>JT</given-names>
          </name>
        </person-group>
        <article-title>Self-affirmation underlies Facebook use</article-title>
        <source>Pers Soc Psychol Bull</source>  
        <year>2013</year>  
        <month>03</month>  
        <volume>39</volume>  
        <issue>3</issue>  
        <fpage>321</fpage>  
        <lpage>31</lpage>  
        <pub-id pub-id-type="doi">10.1177/0146167212474694</pub-id>
        <pub-id pub-id-type="medline">23359086</pub-id>
        <pub-id pub-id-type="pii">0146167212474694</pub-id></nlm-citation>
      </ref>
      <ref id="ref78">
        <label>78</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Gonzales</surname>
            <given-names>AL</given-names>
          </name>
          <name name-style="western">
            <surname>Hancock</surname>
            <given-names>JT</given-names>
          </name>
        </person-group>
        <article-title>Mirror, mirror on my facebook wall: effects of exposure to Facebook on self-esteem</article-title>
        <source>Cyberpsychol Behav Soc Netw</source>  
        <year>2011</year>  
        <volume>14</volume>  
        <issue>1-2</issue>  
        <fpage>79</fpage>  
        <lpage>83</lpage>  
        <pub-id pub-id-type="doi">10.1089/cyber.2009.0411</pub-id>
        <pub-id pub-id-type="medline">21329447</pub-id></nlm-citation>
      </ref>
      <ref id="ref79">
        <label>79</label>
        <nlm-citation citation-type="book">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ellison</surname>
            <given-names>NB</given-names>
          </name>
          <name name-style="western">
            <surname>Lampe</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Steinfield</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Vitak</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <person-group person-group-type="editor">
          <name name-style="western">
            <surname>Papacharissi</surname>
            <given-names>Z</given-names>
          </name>
        </person-group>
        <article-title>With a little help from my friends: how social network sites affect social capital processes</article-title>
        <source>A networked self: identity, community and culture on social network sites</source>  
        <year>2011</year>  
        <publisher-loc>New York</publisher-loc>
        <publisher-name>Routledge</publisher-name></nlm-citation>
      </ref>
      <ref id="ref80">
        <label>80</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Burke</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Kraut</surname>
            <given-names>RE</given-names>
          </name>
        </person-group>
        <article-title>The relationship between facebook use and well-being depends on communication type and tie strength</article-title>
        <source>J Comput Mediat Commun</source>  
        <year>2016</year>  
        <month>07</month>  
        <day>26</day>  
        <volume>21</volume>  
        <issue>4</issue>  
        <fpage>265</fpage>  
        <lpage>81</lpage>  
        <pub-id pub-id-type="doi">10.1111/jcc4.12162</pub-id></nlm-citation>
      </ref>
      <ref id="ref81">
        <label>81</label>
        <nlm-citation citation-type="confproc">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Burke</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Marlow</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Lento</surname>
            <given-names>T</given-names>
          </name>
        </person-group>
        <article-title>Social network activitysocial well-being</article-title>
        <year>2010</year>  
        <conf-name>Proceedings of the SIGCHI Conference on Human Factors in Computing Systems</conf-name>
        <conf-date>April 10-15, 2010</conf-date>
        <conf-loc>Atlanta, GA</conf-loc>
        <publisher-loc>1753613</publisher-loc>
        <publisher-name>ACM</publisher-name>
        <fpage>1909</fpage>  
        <lpage>12</lpage> </nlm-citation>
      </ref>
      <ref id="ref82">
        <label>82</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Tamir</surname>
            <given-names>DI</given-names>
          </name>
          <name name-style="western">
            <surname>Mitchell</surname>
            <given-names>JP</given-names>
          </name>
        </person-group>
        <article-title>Disclosing information about the self is intrinsically rewarding</article-title>
        <source>Proc Natl Acad Sci U S A</source>  
        <year>2012</year>  
        <month>05</month>  
        <day>22</day>  
        <volume>109</volume>  
        <issue>21</issue>  
        <fpage>8038</fpage>  
        <lpage>43</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.pnas.org/cgi/pmidlookup?view=long&#38;pmid=22566617"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1073/pnas.1202129109</pub-id>
        <pub-id pub-id-type="medline">22566617</pub-id>
        <pub-id pub-id-type="pii">1202129109</pub-id>
        <pub-id pub-id-type="pmcid">PMC3361411</pub-id></nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
