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    <front>
        <journal-meta>
            <journal-id journal-id-type="publisher-id">JMIR</journal-id>
            <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
            <journal-title>Journal of Medical Internet Research</journal-title>
            <issn pub-type="epub">1438-8871</issn>
            <publisher>
                <publisher-name>JMIR Publications Inc.</publisher-name>
                <publisher-loc>Toronto, Canada</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="publisher-id">v18i2e39</article-id>
            <article-id pub-id-type="pmid">26887959</article-id>
            <article-id pub-id-type="doi">10.2196/jmir.5343</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Original Paper</subject>
                </subj-group>
                <subj-group subj-group-type="article-type">
                    <subject>Original Paper</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Association Between Media Dose, Ad Tagging, and Changes in Web Traffic for a National Tobacco Education Campaign: A Market-Level Longitudinal Study</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="editor">
                    <name>
                        <surname>Eysenbach</surname>
                        <given-names>Gunther</given-names>
                    </name>
                </contrib>
            </contrib-group>
            <contrib-group>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Vera</surname>
                        <given-names>Lisa</given-names>
                    </name>
                </contrib>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Kite</surname>
                        <given-names>James</given-names>
                    </name>
                </contrib>
            </contrib-group>
            <contrib-group>
                <contrib contrib-type="author" id="contrib1" corresp="yes">
                    <name name-style="western">
                        <surname>Shafer</surname>
                        <given-names>Paul R</given-names>
                    </name>
                    <degrees>MA</degrees>
                    <xref rid="aff1" ref-type="aff">1</xref>
                    <address>
                        <institution>Center for Health Policy Science and Tobacco Research</institution>
                        <institution>RTI International</institution>
                        <addr-line>3040 East Cornwallis Road</addr-line>
                        <addr-line>Research Triangle Park, NC, 27709</addr-line>
                        <country>United States</country>
                        <phone>1 919 260 2711</phone>
                        <fax>1 919 485 5555</fax>
                        <email>pshafer@rti.org</email>
                    </address>
                    <xref rid="aff2" ref-type="aff">2</xref>
                    <ext-link ext-link-type="orcid">http://orcid.org/0000-0003-0654-5821</ext-link>
                </contrib>
                <contrib contrib-type="author" id="contrib2">
                    <name name-style="western">
                        <surname>Davis</surname>
                        <given-names>Kevin C</given-names>
                    </name>
                    <degrees>MA</degrees>
                    <xref rid="aff1" ref-type="aff">1</xref>
                    <ext-link ext-link-type="orcid">http://orcid.org/0000-0001-8517-1295</ext-link>
                </contrib>
                <contrib contrib-type="author" id="contrib3">
                    <name name-style="western">
                        <surname>Patel</surname>
                        <given-names>Deesha</given-names>
                    </name>
                    <degrees>MPH</degrees>
                    <xref rid="aff3" ref-type="aff">3</xref>
                    <ext-link ext-link-type="orcid">http://orcid.org/0000-0003-3080-0642</ext-link>
                </contrib>
                <contrib contrib-type="author" id="contrib4">
                    <name name-style="western">
                        <surname>Rodes</surname>
                        <given-names>Robert</given-names>
                    </name>
                    <degrees>MS</degrees>
                    <xref rid="aff3" ref-type="aff">3</xref>
                    <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-0610-560X</ext-link>
                </contrib>
                <contrib contrib-type="author" id="contrib5">
                    <name name-style="western">
                        <surname>Beistle</surname>
                        <given-names>Diane</given-names>
                    </name>
                    <degrees>BA</degrees>
                    <xref rid="aff3" ref-type="aff">3</xref>
                    <ext-link ext-link-type="orcid">http://orcid.org/0000-0003-0405-5044</ext-link>
                </contrib>
            </contrib-group>
            <aff id="aff1">
                <sup>1</sup>
                <institution>Center for Health Policy Science and Tobacco Research</institution>
                <institution>RTI International</institution>
                <addr-line>Research Triangle Park, NC</addr-line>
                <country>United States</country>
            </aff>
            <aff id="aff2">
                <sup>2</sup>
                <institution>Department of Health Policy and Management</institution>
                <institution>Gillings School of Global Public Health</institution>
                <institution>University of North Carolina at Chapel Hill</institution>
                <addr-line>Chapel Hill, NC</addr-line>
                <country>United States</country>
            </aff>
            <aff id="aff3">
                <sup>3</sup>
                <institution>Office on Smoking and Health</institution>
                <institution>Centers for Disease Control and Prevention</institution>
                <addr-line>Atlanta, GA</addr-line>
                <country>United States</country>
            </aff>
            <author-notes>
                <corresp>Corresponding Author: Paul R Shafer <email>pshafer@rti.org</email>
                </corresp>
            </author-notes>
            <pub-date pub-type="collection">
                <month>02</month>
                <year>2016</year>
            </pub-date>
            <pub-date pub-type="epub">
                <day>17</day>
                <month>02</month>
                <year>2016</year>
            </pub-date>
            <volume>18</volume>
            <issue>2</issue>
            <elocation-id>e39</elocation-id>
            <!--history from ojs - api-xml-->
            <history>
                <date date-type="received">
                    <day>13</day>
                    <month>11</month>
                    <year>2015</year>
                </date>
                <date date-type="rev-request">
                    <day>2</day>
                    <month>12</month>
                    <year>2015</year>
                </date>
                <date date-type="rev-recd">
                    <day>14</day>
                    <month>12</month>
                    <year>2015</year>
                </date>
                <date date-type="accepted">
                    <day>3</day>
                    <month>1</month>
                    <year>2016</year>
                </date>
            </history>
            <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
            <copyright-statement>&#169;Paul R Shafer, Kevin C Davis, Deesha Patel, Robert Rodes, Diane Beistle. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 17.02.2016. </copyright-statement>
            <copyright-year>2016</copyright-year>
            <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/">
                <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.</p>
            </license>
            <self-uri xlink:href="http://www.jmir.org/2016/2/e39/" xlink:type="simple" />
            <abstract>
                <sec sec-type="background">
                    <title>Background</title>
                    <p>In 2012, the US Centers for Disease Control and Prevention (CDC) launched <italic>Tips From Former Smokers (Tips)</italic>, the first federally funded national tobacco education campaign. In 2013, a follow-up <italic>Tips</italic> campaign aired on national cable television networks, radio, and other channels, with supporting digital advertising to drive traffic to the <italic>Tips</italic> campaign website.</p>
                </sec>
                <sec sec-type="objective">
                    <title>Objective</title>
                    <p>The objective of this study was to use geographic and temporal variability in 2013 <italic>Tips</italic> campaign television media doses and ad tagging to evaluate changes in traffic to the campaign website in response to specific doses of campaign media.</p>
                </sec>
                <sec sec-type="methods">
                    <title>Methods</title>
                    <p>Linear regression models were used to estimate the dose-response relationship between weekly market-level television gross rating points (GRPs) and weekly Web traffic to the <italic>Tips</italic> campaign website. This relationship was measured using unique visitors, total visits, and page views as outcomes. Ad GRP effects were estimated separately for ads tagged with the <italic>Tips</italic> campaign website URL and 1-800-QUIT-NOW.</p>
                </sec>
                <sec sec-type="results">
                    <title>Results</title>
                    <p>In the average media market, an increase of 100 television GRPs per week for ads tagged with the <italic>Tips</italic> campaign website URL was associated with an increase of 650 unique visitors (<italic>P</italic>&#60;.001), 769 total visits (<italic>P</italic>&#60;.001), and 1255 total page views (<italic>P</italic>&#60;.001) per week. The associations between GRPs for ads tagged with 1-800-QUIT-NOW and each Web traffic measure were also statistically significant (<italic>P</italic>&#60;.001), but smaller in magnitude.</p>
                </sec>
                <sec sec-type="conclusions">
                    <title>Conclusions</title>
                    <p>Based on these findings, we estimate that the 16-week 2013 <italic>Tips</italic> television campaign generated approximately 660,000 unique visitors, 900,000 total visits, and 1,390,000 page views for the <italic>Tips</italic> campaign website. These findings can help campaign planners forecast the likely impact of targeted advertising efforts on consumers&#8217; use of campaign-specific websites.</p>
                </sec>
            </abstract>
            <kwd-group>
                <kwd>Internet</kwd>
                <kwd>advertising</kwd>
                <kwd>health communication</kwd>
                <kwd>smoking cessation</kwd>
                <kwd>public health</kwd>
                <kwd>tobacco control</kwd>
            </kwd-group>
        </article-meta>
    </front>
    <body>
        <sec sec-type="introduction">
            <title>Introduction</title>
            <p>As websites and social media have evolved into powerful channels for tobacco advertising [<xref ref-type="bibr" rid="ref1">1</xref>], they have also become a vital component of health education campaigns. Daily Internet use is high among US adults (82%) and most Internet users (80%) report searching for health-related information online [<xref ref-type="bibr" rid="ref2">2</xref>]. State tobacco control programs have accelerated their creation of state-sponsored websites and social media accounts [<xref ref-type="bibr" rid="ref2">2</xref>], offering multiple platforms to tobacco users for outreach and cessation interventions. Furthermore, Web analytics have evolved to allow organizations to assess the effectiveness of campaigns on increasing traffic to websites [<xref ref-type="bibr" rid="ref3">3</xref>].</p>
            <p>In 2012, the US Centers for Disease Control and Prevention (CDC) launched <italic>Tips From Former Smokers</italic> (<italic>Tips</italic>), the first federally funded national tobacco education campaign, resulting in an estimated additional 1.6 million quit attempts nationally [<xref ref-type="bibr" rid="ref4">4</xref>]. A second wave of <italic>Tips</italic> aired from March 4 to June 21, 2013, using similar creative content&#8212;graphic, emotional advertisements portraying the health consequences of smoking. Approximately one-third of all television ads were tagged with the <italic>Tips</italic> campaign website URL [<xref ref-type="bibr" rid="ref5">5</xref>], while two-thirds promoted the national 1-800-QUIT-NOW telephone quitline. The 2013 campaign was also supported by digital advertising, including online video, display, mobile, and paid search ads.</p>
            <p>Previous research has shown that weekly traffic to the <italic>Tips</italic> website increased dramatically during the 2013 <italic>Tips</italic> campaign compared with the 4 weeks before and after the campaign [<xref ref-type="bibr" rid="ref6">6</xref>]. However, a limitation of this analysis was the use of a pre-post analysis that assesses changes in Web traffic purely as a function of campaign airdates. This approach fails to account for variation in media dose during the campaign (ie, temporal variation) and across media markets (ie, geographic variation), in addition to the differences in population and sociodemographic characteristics of each market. To our knowledge, no studies have examined the relationship between varying doses of advertising for a national health education campaign and the magnitude of changes in Web traffic over time. To address this gap in the literature, we used geographic and temporal variation in 2013 <italic>Tips</italic> gross rating points (GRPs) to quantify market-level changes in use of the <italic>Tips</italic> website in response to specific unit increases in weekly dose of GRPs. These results were used to estimate the additional traffic to the <italic>Tips</italic> website attributable to the 2013 <italic>Tips</italic> television ads tagged with the <italic>Tips</italic> campaign website URL or 1-800-QUIT-NOW.</p>
        </sec>
        <sec sec-type="methods">
            <title>Methods</title>
            <sec>
                <title>Outcome Variables</title>
                <p>We assessed three primary outcomes of Web traffic to the <italic>Tips</italic> website: (1) total unique visitors, (2) total visits, and (3) total page views. These metrics were derived from Adobe SiteCatalyst, a tool that provides utilization and engagement metrics for websites.</p>
                <p>Unique visitors included the total number of unique individuals who visited the site during a given period, regardless of number of repeat visits by each individual. Visits are defined as the total number of visits made to the website during a given time period. A visit occurs when an individual arrives at and navigates the website, even if the individual has previously visited the site. A visit may consist of multiple page views, and each individual visit continues until there are 30 minutes of browser inactivity or 12 hours of continuous activity. Page views are the total number of times that individual website pages are viewed. For example, if one user views five pages on the site, this represents five total page views for that period. For these three aforementioned outcomes, metrics for each of the 210 US media markets were aggregated for each of the 16 weeks of the 2013 <italic>Tips</italic> campaign and for the 4 weeks before and after the campaign&#8212;24 weeks total.</p>
            </sec>
            <sec>
                <title>Control Variables</title>
                <p>The primary measure of 2013 <italic>Tips</italic> exposure was weekly media market-level GRPs for television ads. GRPs measure the relative &#8220;dose&#8221; of advertising delivered to a target audience in a given media market and time period. They are defined as the product of the proportion of an audience that is potentially exposed (ie, audience reach) and the frequency of that exposure (ie, number of times an ad was aired). For example, if a television ad reaches 50% of an audience twice in one week, the GRP for this ad during that week is 100 (50 x 2) [<xref ref-type="bibr" rid="ref7">7</xref>].</p>
                <p>During 2013 <italic>Tips</italic>, CDC also delivered a significantly higher dose of digital video advertising to three media markets&#8212;Cleveland, Ohio; Sacramento, California; and Tampa, Florida. This additional digital video advertising used the same creative content as the television ads, all of which were linked to the <italic>Tips</italic> website. To account for the impact of this higher dose of digital video advertising on Web traffic in these three markets, separately from the main effect of <italic>Tips</italic> television GRPs, our analysis included an indicator (fixed effect) for the higher-dose markets that is equal to 1 for those three markets and 0 otherwise.</p>
            </sec>
            <sec>
                <title>Statistical Analysis</title>
                <p>We used linear regression models to estimate each outcome variable at the media market level as a function of market-level weekly television GRPs (in 100s) tagged with the <italic>Tips</italic> website URL and GRPs tagged with 1-800-QUIT-NOW. We estimated separate models to assess the impact of each type of ad tagging. We also controlled for week of the campaign; additional state-funded airings of <italic>Tips</italic> ads, measured with GRPs (in 100s); and market-level sociodemographic characteristics, including total population (in 10,000s), cigarette smoking prevalence (0-100), percentage African American (0-100), percentage Hispanic (0-100), percentage with a bachelor&#8217;s degree (0-100), and median income (in US dollars). Linear predictions were made using the observed <italic>Tips</italic> GRP effect and effect of higher-dose digital advertising (actual) and an alternate scenario that assumed zero television GRPs and no higher-dose digital advertising (counterfactual). The differences between the actual and counterfactual predictions for each outcome are reported as the campaign-attributable effects. All analyses were conducted using Stata 13.2 (StataCorp LP) [<xref ref-type="bibr" rid="ref8">8</xref>].</p>
            </sec>
        </sec>
        <sec sec-type="results">
            <title>Results</title>
            <p>An increase of 100 television GRPs per week for ads tagged with the <italic>Tips</italic> website URL was associated with increases of 650 unique visitors (<italic>P</italic>&#60;.001), 769 total visits (<italic>P</italic>&#60;.001), and 1255 total page views (<italic>P</italic>&#60;.001) per week in each media market (see <xref ref-type="table" rid="table1">Table 1</xref>). An increase of 100 television GRPs per week for ads tagged with 1-800-QUIT-NOW was associated with increases of 280 unique visitors (<italic>P</italic>&#60;.001), 334 total visits (<italic>P</italic>&#60;.001), and 547 page views (<italic>P</italic>&#60;.001) per week in each media market. State-funded <italic>Tips</italic> campaign GRPs were not associated with measures of Web traffic. Media markets that received higher-dose digital advertising had approximately 2950 more unique visitors (<italic>P</italic>&#60;.001), 6050 more visits (<italic>P</italic>&#60;.001), and nearly 8150 more page views (<italic>P</italic>&#60;.001) at the <italic>Tips</italic> website per week than markets that did not receive higher-dose digital advertising. Increases in market-level smoking prevalence were significantly associated with lower weekly Web traffic. Specifically, a 1% increase in smoking prevalence was associated with a decrease of approximately 19 unique visitors, 21 visits, and 28 page views per week.</p>
            <p>Based on these findings, we estimate that 2013 <italic>Tips</italic> was responsible for approximately 660,000 additional unique visitors, 900,000 additional visits, and 1,390,000 additional page views to the <italic>Tips</italic> website over the course of the 16-week campaign (see <xref ref-type="table" rid="table2">Table 2</xref>).</p>
            <table-wrap position="float" id="table1">
                <label>Table 1</label>
                <caption>
                    <p>Multivariate regressions for Web traffic as a function of 2013 <italic>Tips</italic> campaign dose.</p>
                </caption>
                <table width="684" border="1" cellpadding="8" cellspacing="0" rules="groups" frame="hsides">
                    <col width="243" />
                    <col width="56" />
                    <col width="62" />
                    <col width="52" />
                    <col width="56" />
                    <col width="50" />
                    <col width="52" />
                    <thead>
                        <tr valign="top">
                            <td rowspan="2">Independent variable</td>
                            <td colspan="3">
                                <italic>Tips</italic> website URL,<break />ad model coefficient (SE), <italic>P</italic>
                            </td>
                            <td colspan="3">1-800-QUIT-NOW,<break />ad model coefficient (SE), <italic>P</italic>
                            </td>
                        </tr>
                        <tr valign="top">
                            <td>Unique visitors</td>
                            <td>Visits</td>
                            <td>Page views</td>
                            <td>Unique visitors</td>
                            <td>Visits</td>
                            <td>Page views</td>
                        </tr>
                    </thead>
                    <tbody>
                        <tr valign="top">
                            <td>Weekly GRPs<sup>a</sup> for ads tagged with <italic>Tips</italic> campaign website URL (in 100s)</td>
                            <td>650.2<break />(59.8),<break />&#60;.001</td>
                            <td>768.5<break />(77.3),<break />&#60;.001</td>
                            <td>1254.6<break />(116.7),<break />&#60;.001</td>
                            <td>N/A<sup>b</sup>
                            </td>
                            <td>N/A</td>
                            <td>N/A</td>
                        </tr>
                        <tr valign="top">
                            <td>Weekly GRPs for ads tagged with 1-800-QUIT-NOW (in 100s)</td>
                            <td>N/A</td>
                            <td>N/A</td>
                            <td>N/A</td>
                            <td>279.6<break />(27.3),<break />&#60;.001</td>
                            <td>333.8<break />(35.3),<break />&#60;.001</td>
                            <td>546.7<break />(53.3),<break />&#60;.001</td>
                        </tr>
                        <tr valign="top">
                            <td>Weekly state-funded GRPs (in 100s)</td>
                            <td>11.5<break />(6.0),<break />.06</td>
                            <td>12.2<break />(7.8),<break />.12</td>
                            <td>19.3<break />(11.8),<break />.10</td>
                            <td>11.6<break />(6.0),<break />.05</td>
                            <td>12.4<break />(7.8),<break />.11</td>
                            <td>19.6<break />(11.8),<break />.10</td>
                        </tr>
                        <tr valign="top">
                            <td>Digital advertising higher-dose markets</td>
                            <td>2951.8<break />(98.2),<break />&#60;.001</td>
                            <td>6051.3<break />(126.9),<break />&#60;.001</td>
                            <td>8173.3<break />(191.6),<break />&#60;.001</td>
                            <td>2956.1<break />(98.3),<break />&#60;.001</td>
                            <td>6056.6<break />(127.0),<break />&#60;.001</td>
                            <td>8182.0<break />(191.8),<break />&#60;.001</td>
                        </tr>
                        <tr valign="top">
                            <td>Population of market (in 10,000s)</td>
                            <td>-330.8<break />(33.3),<break />&#60;.001</td>
                            <td>-358.6<break />(43.0),<break />&#60;.001</td>
                            <td>-602.8<break />(64.9),<break />&#60;.001</td>
                            <td>-331.7<break />(33.3),<break />&#60;.001</td>
                            <td>-359.5<break />(43.0),<break />&#60;.001</td>
                            <td>-546.7<break />(53.3),<break />&#60;.001</td>
                        </tr>
                        <tr valign="top">
                            <td>Smoking prevalence of market</td>
                            <td>-19.6<break />(5.8),<break />.001</td>
                            <td>-22.0<break />(7.5),<break />.003</td>
                            <td>-28.7<break />(11.3),<break />.01</td>
                            <td>-19.0<break />(5.8),<break />.001</td>
                            <td>-21.4<break />(7.5),<break />.005</td>
                            <td>-27.7<break />(11.3),<break />.02</td>
                        </tr>
                        <tr valign="top">
                            <td>Percentage of market population that is African American</td>
                            <td>11.9<break />(0.9),<break />&#60;.001</td>
                            <td>12.8<break />(1.2),<break />&#60;.001</td>
                            <td>20.7<break />(1.8),<break />&#60;.001</td>
                            <td>12.0<break />(0.9),<break />&#60;.001</td>
                            <td>12.9<break />(1.2),<break />&#60;.001</td>
                            <td>20.8<break />(1.8),<break />&#60;.001</td>
                        </tr>
                        <tr valign="top">
                            <td>Percentage of market population that is Hispanic</td>
                            <td>8.9<break />(1.1),<break />&#60;.001</td>
                            <td>9.7<break />(1.4),<break />&#60;.001</td>
                            <td>15.8<break />(2.1),<break />&#60;.001</td>
                            <td>9.0<break />(1.1),<break />&#60;.001</td>
                            <td>9.7<break />(1.4),<break />&#60;.001</td>
                            <td>15.9<break />(2.1),<break />&#60;.001</td>
                        </tr>
                        <tr valign="top">
                            <td>Percentage of market population that has a bachelor&#8217;s degree or higher</td>
                            <td>-11.3<break />(3.4),<break />.001</td>
                            <td>-12.4<break />(4.4),<break />.005</td>
                            <td>-15.7<break />(6.7),<break />.02</td>
                            <td>-11.1<break />(3.4),<break />.001</td>
                            <td>-12.2<break />(4.4),<break />.006</td>
                            <td>-15.5<break />(6.7),<break />.02</td>
                        </tr>
                        <tr valign="top">
                            <td>Median income in market</td>
                            <td>0<break />(0),<break />&#60;.001</td>
                            <td>0.1<break />(0),<break />&#60;.001</td>
                            <td>0.1<break />(0),<break />&#60;.001</td>
                            <td>0<break />(0),<break />&#60;.001</td>
                            <td>0.1<break />(0),<break />&#60;.001</td>
                            <td>0.1<break />(0)<break />&#60;.001</td>
                        </tr>
                        <tr valign="top">
                            <td>Week of the campaign</td>
                            <td>-1.0<break />(1.7),<break />.57</td>
                            <td>-0.2<break />(2.2),<break />.91</td>
                            <td>1.1<break />(3.3),<break />.74</td>
                            <td>0.2<break />(1.7),<break />.92</td>
                            <td>1.1<break />(2.2),<break />.61</td>
                            <td>3.3<break />(3.3),<break />.31</td>
                        </tr>
                        <tr valign="top">
                            <td>Number of observations, n</td>
                            <td>5040</td>
                            <td>5040</td>
                            <td>5040</td>
                            <td>5040</td>
                            <td>5040</td>
                            <td>5040</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <fn id="table1fn1">
                        <p>
                            <sup>a</sup>GRP: gross rating point.</p>
                    </fn>
                    <fn id="table1fn2">
                        <p>
                            <sup>b</sup>N/A: not applicable.</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
            <table-wrap position="float" id="table2">
                <label>Table 2</label>
                <caption>
                    <p>Linear predictions of 2013 <italic>Tips</italic> campaign-attributable effects on unique visitors, visits, and page views for <italic>Tips</italic> campaign website.</p>
                </caption>
                <table width="638" border="1" cellpadding="7" cellspacing="0" rules="groups" frame="hsides">
                    <col width="297" />
                    <col width="114" />
                    <col width="82" />
                    <col width="88" />
                    <thead>
                        <tr valign="top">
                            <td>Prediction scenario<sup>a</sup>
                            </td>
                            <td>Unique visitors<sup>b</sup>, n</td>
                            <td>Visits<sup>c</sup>, n</td>
                            <td>Page views<sup>d</sup>, n</td>
                        </tr>
                    </thead>
                    <tbody>
                        <tr valign="top">
                            <td>Actual (observed campaign)</td>
                            <td>1,560,000</td>
                            <td>1,850,000</td>
                            <td>2,950,000</td>
                        </tr>
                        <tr valign="top">
                            <td>Counterfactual (no campaign)</td>
                            <td>900,000</td>
                            <td>950,000</td>
                            <td>1,560,000</td>
                        </tr>
                        <tr valign="top">
                            <td>Difference (campaign-attributable effect)</td>
                            <td>660,000</td>
                            <td>900,000</td>
                            <td>1,390,000</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <fn id="table2fn1">
                        <p>
                            <sup>a</sup>All predictions are rounded to the nearest 10,000.</p>
                    </fn>
                    <fn id="table2fn2">
                        <p>
                            <sup>b</sup>Unique visitors represents the number of unique users of the website over a given time period.</p>
                    </fn>
                    <fn id="table2fn3">
                        <p>
                            <sup>c</sup>Visits represents total number of visits (including multiples by the same individual) to the website over a given period.</p>
                    </fn>
                    <fn id="table2fn4">
                        <p>
                            <sup>d</sup>Page views represents the total number of pages viewed on the website [<xref ref-type="bibr" rid="ref5">5</xref>] across all visits in a given period.</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
        </sec>
        <sec sec-type="discussion">
            <title>Discussion</title>
            <sec>
                <title>Principal Findings</title>
                <p>This is the first study to quantify specific dosing levels for television advertising that are associated with weekly traffic to the <italic>Tips</italic> website. Although the estimated campaign-attributable increase in visits is substantial, the increase estimated in this study&#8212;660,000 additional unique visitors&#8212;is lower than the estimated 2.8 million additional unique visitors reported in earlier aggregate results [<xref ref-type="bibr" rid="ref6">6</xref>]. Our estimates are likely more conservative because this analysis specifically quantifies the response of website use to specific unit increases in media doses while controlling for potential confounders, as opposed to a more crude approach of comparing Web traffic during the campaign period to time periods before and after the campaign.</p>
                <p>As expected, the impact on Web traffic of ads tagged with 1-800-QUIT-NOW was smaller than the effect of ads tagged with the <italic>Tips</italic> website URL. The existence of an association with 1-800-QUIT-NOW tagging suggests that <italic>Tips</italic> ads, regardless of tagging, may generate measurable traffic to the <italic>Tips</italic> website. We also found that after adjusting for market-level sociodemographic characteristics, the higher-dose digital video advertising was associated with substantial increases in Web traffic. These findings demonstrate that a targeted digital strategy can help drive consumers to online resources offered by campaigns.</p>
                <p>Our study is limited by the relatively short period of pre- and postcampaign Web traffic data available at the media market level (4 weeks before and after) compared to the length of the campaign (16 weeks). Our estimates may also be understated because traffic from users whose market location could not be established were excluded from the analysis. We also cannot establish that visitors to the campaign website were looking for cessation information, though with data on specific pages viewed, such an analysis would be possible and could establish an important link between increases in traffic to campaign websites and information-seeking for health education.</p>
            </sec>
            <sec>
                <title>Conclusions</title>
                <p>In conclusion, this analysis demonstrates a significant relationship between specific doses of television advertising and the magnitude of changes in campaign Web traffic over time. This is important given that one of the primary functions of the <italic>Tips</italic> campaign website is to provide smokers with information and resources to help quit; it is likely that many of the additional visitors are smokers seeking help in quitting. This study shows that direct tagging of traditional television ads with campaign website addresses and/or targeted digital advertising strategies can play a direct role in increasing the use of health-related online resources, independently of the dose-response effect of campaign intensity on Web traffic. These findings may help campaign planners forecast the likely impact of advertising efforts on consumers&#8217; use of campaign-specific websites and optimize their campaigns to increase use of online resources.</p>
            </sec>
        </sec>
    </body>
    <back>
        <glossary>
            <title>Abbreviations</title>
            <def-list>
                <def-item>
                    <term id="abb1">CDC</term>
                    <def>
                        <p>Centers for Disease Control and Prevention</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb2">GRP</term>
                    <def>
                        <p>gross rating point</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb3">N/A</term>
                    <def>
                        <p>not applicable</p>
                    </def>
                </def-item>
            </def-list>
        </glossary>
        <ack>
            <p>This work was funded by the Centers for Disease Control and Prevention. The findings and conclusions in this manuscript are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention or RTI International. The authors would like to acknowledge Caryn Coln and Amy Rowland for providing the data and answering follow-up questions needed for the analysis.</p>
        </ack>
        <fn-group>
            <fn fn-type="con">
                <p>PS led drafting of the manuscript and conducted the analysis. KD assisted with study design and drafting of the manuscript. DP assisted in the drafting of the manuscript. RR and DB assisted in the implementation of the media buy and provided feedback on the manuscript.</p>
            </fn>
            <fn fn-type="conflict">
                <p>None declared.</p>
            </fn>
        </fn-group>
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