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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
    <article-id pub-id-type="publisher-id">v18i12e337</article-id>
    <article-id pub-id-type="pmid">28011445</article-id>
    <article-id pub-id-type="doi">10.2196/jmir.6003</article-id>
    <article-categories>
      <subj-group subj-group-type="heading">
        <subject>Original Paper</subject>
      </subj-group>
      <subj-group subj-group-type="article-type">
        <subject>Original Paper</subject>
      </subj-group>
    </article-categories>
    <title-group>
      <article-title>Drivers and Barriers to Acceptance of Web-Based Aftercare of Patients in Inpatient Routine Care: A Cross-Sectional Survey</article-title>
    </title-group>
    <contrib-group>
      <contrib contrib-type="editor">
        <name>
          <surname>Eysenbach</surname>
          <given-names>Gunther</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Eichenberg</surname>
          <given-names>Christiane</given-names>
        </name>
      </contrib>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Neter</surname>
          <given-names>Efrat</given-names>
        </name>
      </contrib>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Tavares</surname>
          <given-names>Jorge</given-names>
        </name>
      </contrib>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Moessner</surname>
          <given-names>Markus</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="author" id="contrib1">
        <name name-style="western">
          <surname>Hennemann</surname>
          <given-names>Severin</given-names>
        </name>
        <degrees>Dipl-Psych</degrees>
        <xref rid="aff1" ref-type="aff">1</xref>
        <xref rid="aff2" ref-type="aff">2</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0001-8780-9985</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib2">
        <name name-style="western">
          <surname>Beutel</surname>
          <given-names>Manfred E</given-names>
        </name>
        <degrees>PhD</degrees>
        <xref rid="aff1" ref-type="aff">1</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0003-1743-0042</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib3" corresp="yes">
      <name name-style="western">
        <surname>Zwerenz</surname>
        <given-names>Rüdiger</given-names>
      </name>
      <degrees>PhD</degrees>
      <xref rid="aff1" ref-type="aff">1</xref>
      <address>
        <institution>Department of Psychosomatic Medicine and Psychotherapy</institution>
        <institution>University Medical Center</institution>
        <institution>Gutenberg University Mainz</institution>
        <addr-line>Untere Zahlbacher Str. 8</addr-line>
        <addr-line>Mainz, 55131</addr-line>
        <country>Germany</country>
        <phone>49 6131 175981</phone>
        <fax>49 6131 175563</fax>
        <email>ruediger.zwerenz@unimedizin-mainz.de</email>
      </address>  
      <ext-link ext-link-type="orcid">http://orcid.org/0000-0003-1491-0905</ext-link></contrib>
    </contrib-group>
    <aff id="aff1">
    <sup>1</sup>  
    <institution>Department of Psychosomatic Medicine and Psychotherapy</institution>  
    <institution>University Medical Center</institution>
    <institution>Gutenberg University Mainz</institution>  
    <addr-line>Mainz</addr-line>
    <country>Germany</country></aff>
    <aff id="aff2">
    <sup>2</sup>    <institution>Department of Clinical Psychology, Psychotherapy and Experimental Psychopathology</institution>  
    <institution>Institute of Psychology</institution>

    <institution>University of Mainz</institution>  
    <addr-line>Mainz</addr-line>
    <country>Germany</country></aff>
    <author-notes>
      <corresp>Corresponding Author: Rüdiger Zwerenz 
      <email>ruediger.zwerenz@unimedizin-mainz.de</email></corresp>
    </author-notes>
    <pub-date pub-type="collection"><month>12</month><year>2016</year></pub-date>
    <pub-date pub-type="epub">
      <day>23</day>
      <month>12</month>
      <year>2016</year>
    </pub-date>
    <volume>18</volume>
    <issue>12</issue>
    <elocation-id>e337</elocation-id>
    <!--history from ojs - api-xml-->
    <history>
      <date date-type="received">
        <day>20</day>
        <month>5</month>
        <year>2016</year>
      </date>
      <date date-type="rev-request">
        <day>24</day>
        <month>8</month>
        <year>2016</year>
      </date>
      <date date-type="rev-recd">
        <day>7</day>
        <month>10</month>
        <year>2016</year>
      </date>
      <date date-type="accepted">
        <day>22</day>
        <month>10</month>
        <year>2016</year>
      </date>
    </history>
    <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
    <copyright-statement>©Severin Hennemann, Manfred E Beutel, Rüdiger Zwerenz. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 23.12.2016.</copyright-statement>
    <copyright-year>2016</copyright-year>
    <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/">
      <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.</p>
    </license>  
    <self-uri xlink:href="http://www.jmir.org/2016/12/e337/" xlink:type="simple"/>
    <abstract>
      <sec sec-type="background">
        <title>Background</title>
        <p>Web-based aftercare can help to stabilize treatment effects and support transition after inpatient treatment, yet uptake by patients seems limited in routine care and little is known about the mechanisms of adoption and implementation.</p>
      </sec>
      <sec sec-type="objective">
        <title>Objective</title>
        <p>The aim of this study was to (1) determine acceptance of Web-based aftercare and (2) explore its drivers and barriers in different subgroups of a mixed inpatient sample.</p>
      </sec>
      <sec sec-type="method">
        <title>Method</title>
        <p>In a cross-sectional design, 38.3% (374/977) of the inpatients from a broad spectrum of diagnostic groups (psychosomatic, cardiologic, orthopedic, pediatric, and substance-related disorders) filled out a self-administered questionnaire prior to discharge. Drivers and barriers to patients’ acceptance of Web-based aftercare were examined based on an extension to the “unified theory of acceptance and use of technology” (UTAUT). In total, 16.7% (59/353) of the participants indicated prior use of eHealth interventions.</p>
      </sec>
      <sec sec-type="results">
        <title>Results</title>
        <p>Acceptance (min 1, max 5) was low (mean 2.56, SD 1.22) and differed between diagnostic groups (Welch <italic>F</italic><sub>4,133.10</sub> =7.77, <italic>P</italic>&#60;.001), with highest acceptance in adolescent patients (mean 3.46, SD 1.42). Acceptance was significantly predicted by 3 UTAUT predictors: social influence (beta=.39, <italic>P</italic>&#60;.001), performance expectancy (beta=.31, <italic>P</italic>&#60;.001), and effort expectancy (beta=.22, <italic>P</italic>&#60;.001). Furthermore, stress due to permanent availability (beta=−.09, <italic>P</italic>=.01) was negatively associated with acceptance.</p>
      </sec>
      <sec sec-type="conclusion">
        <title>Conclusion</title>
        <p>This study demonstrated a limited acceptance of Web-based aftercare in inpatients. Expectations, social environment’s attitude, and negative experience with permanent availability influence eHealth acceptance. Improving implementation, therefore, means increasing eHealth experience and literacy and facilitating positive attitudes in patients and health professionals through education and reduction of misconceptions about effectiveness or usability.</p>
      </sec>
    </abstract>
    <kwd-group>
      <kwd>eHealth</kwd>
      <kwd>attitude to health</kwd>
      <kwd>aftercare</kwd>
      <kwd>rehabilitation</kwd>
      <kwd>survey</kwd>
    </kwd-group></article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>The digitalization of health care brought forth a broad range of effective eHealth interventions for various somatic [<xref ref-type="bibr" rid="ref1">1</xref>] and mental health problems [<xref ref-type="bibr" rid="ref2">2</xref>]. The effects of guided interventions for some mental disorders turned out to be comparable to those of traditional face-to-face therapy [<xref ref-type="bibr" rid="ref3">3</xref>]. eHealth interventions can be a cost-efficient, time-flexible, and location-independent extension of existing health care [<xref ref-type="bibr" rid="ref4">4</xref>], particularly in areas such as prevention, as aftercare or blended care. In the case of inpatient rehabilitation, previous research focused on Web-based aftercare [<xref ref-type="bibr" rid="ref5">5</xref>], as the transition to daily life after inpatient treatment is a critical phase, with elevated risk of relapse, sick leave, return to adverse health behavior, or even inpatient readmission [<xref ref-type="bibr" rid="ref6">6</xref>]. Therefore, clinics often recommend participation in outpatient treatment and aftercare (eg, physiotherapy, vocational rehabilitation, educative group sessions). However, organizational constraints or limited accessibility, concerns about anonymity, or negative treatment expectancies can reduce the utilization of conventional outpatient treatment or aftercare [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref8">8</xref>]. In this regard, Köpke [<xref ref-type="bibr" rid="ref9">9</xref>] describes insufficient uptake rates of conventional aftercare interventions between 18.9% for somatic and 69.6% for psychosomatic disorders after inpatient rehabilitation in Germany.</p>
        <p>Previous Web-based aftercare interventions have been developed and evaluated particularly for psychosomatic inpatients, for example, cognitive behavioral therapy (CBT)–based Internet platforms [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref11">11</xref>] or mobile interventions [<xref ref-type="bibr" rid="ref12">12</xref>], providing modular or consecutive treatment elements with a combination of health-related information and interactive tasks to promote health behavior (see also <xref ref-type="app" rid="app1">Multimedia Appendix 1</xref>). Furthermore, interventions differ by amount of guidance by health experts [<xref ref-type="bibr" rid="ref13">13</xref>], who support health behavior and self-efficacy through synchronous (eg, video- or chat-based) [<xref ref-type="bibr" rid="ref14">14</xref>] or asynchronous (email, short message service) [<xref ref-type="bibr" rid="ref11">11</xref>] interaction and task-related feedback. Most Web-based aftercare interventions with psychosomatic focus are CBT based, whereas more recent developments include psychodynamic [<xref ref-type="bibr" rid="ref15">15</xref>] or acceptance- and commitment-based approaches [<xref ref-type="bibr" rid="ref16">16</xref>].</p>
        <p>However, despite an increased proportion of inpatients with pronounced work-related stress and subsequently an elevated risk of early retirement [<xref ref-type="bibr" rid="ref17">17</xref>], occupational aspects play a subsidiary role in eHealth interventions in the context of inpatient treatment. Only a few projects explicitly addressed work-related stress in clinical or subclinical samples and yielded mixed effects [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>]. As the digitalization of health care is still in its early stages in Germany, eHealth interventions are scarce in inpatient care, with only 9% of studies on eHealth interventions in the area of rehabilitation according to Eichenberg and Ott [<xref ref-type="bibr" rid="ref20">20</xref>].</p>
        <p>A fundamental precondition to the implementation of eHealth interventions is the willingness to utilize and adopt new technologies by patients and help seekers [<xref ref-type="bibr" rid="ref21">21</xref>]. Despite their efficacy, uptake of and adherence in eHealth interventions pose a challenge for implementation in routine care [<xref ref-type="bibr" rid="ref22">22</xref>], and mechanisms of uptake of eHealth interventions and their relevance to implementation have not been studied sufficiently yet.</p>
      </sec>
      <sec>
        <title>Acceptance of E-Mental Health Interventions</title>
        <p>Acceptance can imply the utilization of an intervention, as expressed in uptake rates, adherence, or satisfaction. Following theoretical models of acceptance of information technology, acceptance can also be defined as the behavioral intention to use eHealth interventions [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref24">24</xref>] as an essential prerequisite to adoption and implementation of eHealth interventions.</p>
        <p>Based on their review of 36 studies, Waller and Gilbody [<xref ref-type="bibr" rid="ref25">25</xref>] concluded that participants’ satisfaction with computerized CBT (cCBT) is usually high; however, the willingness to participate is limited, with only 38% starting the intervention after recruitment. Other findings are inconsistent, with various studies documenting a low uptake rate of e-mental health interventions by patients [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref25">25</xref>] or limited acceptance in the general population [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref27">27</xref>].</p>
        <p>According to a recent representative population survey in Germany, less than 10% of the interviewed participants could imagine using psychological Web-based support and merely 2% had already used such services in the past [<xref ref-type="bibr" rid="ref27">27</xref>]. Whereas recent studies point to the acceptance of eHealth records and computer-based diagnostic systems in inpatient treatment [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref29">29</xref>], preliminary evidence on some Web-based aftercare projects in German rehabilitation shows fluctuating uptake rates between 21% and 62% [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref12">12</xref>]. <xref ref-type="app" rid="app1">Multimedia Appendix 1</xref> compares acceptance ratings (eg, uptake, adherence) of exemplary Web-based aftercare interventions including guided self-help [<xref ref-type="bibr" rid="ref11">11</xref>], blended [<xref ref-type="bibr" rid="ref31">31</xref>], mobile-based [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref32">32</xref>], and chat- or education based [<xref ref-type="bibr" rid="ref33">33</xref>-<xref ref-type="bibr" rid="ref36">36</xref>] interventions. The results of Pfaudler et al [<xref ref-type="bibr" rid="ref33">33</xref>] and Küffner [<xref ref-type="bibr" rid="ref35">35</xref>] indicate organizational and technical problems as pivotal barriers to adoption by inpatients.</p>
      </sec>
      <sec>
        <title>Methodical Shortcomings of Acceptance Assessment</title>
        <p>Although acceptance ratings have been included in most studies on eHealth interventions by now, methodical shortcomings may somehow limit their validity. Since acceptance is typically assessed retrospectively, no information about genuine attitudes toward this form of health promotion or reasons for intention to use an intervention is provided. Furthermore, acceptance ratings may be confounded with intervention satisfaction and do not reflect eHealth acceptance or attitudes. A selective dropout of dissatisfied participants and participation of Internet-oriented patients may also positively bias acceptance ratings. The lack of sufficient theoretical foundation and valid or consistent instruments of acceptance evaluation can further be criticized [<xref ref-type="bibr" rid="ref21">21</xref>]. A recent example for a methodical valuable approach is the 4-dimensional “Attitudes toward psychological online interventions” questionnaire (APOI), which has been cross-validated in a large sample of individuals with symptoms of depression [<xref ref-type="bibr" rid="ref37">37</xref>]. Furthermore, previous studies focused on acceptance in rather selected patient samples. Hence, comprehensive findings from inpatient treatment are scarce. Altogether, these methodological shortcomings may illustrate the importance of a differentiated, theory-based, and transdiagnostic assessment of eHealth acceptance and its preconditions.</p>
      </sec>
      <sec>
        <title>Barriers and Resources to eHealth Acceptance</title>
        <p>Research on predictors of eHealth acceptance has established the technology acceptance model (TAM) [<xref ref-type="bibr" rid="ref23">23</xref>], and its advancement, the unified theory of acceptance and use of technology (UTAUT) [<xref ref-type="bibr" rid="ref24">24</xref>] in several studies in patient populations [<xref ref-type="bibr" rid="ref38">38</xref>-<xref ref-type="bibr" rid="ref41">41</xref>] or health professionals [<xref ref-type="bibr" rid="ref42">42</xref>-<xref ref-type="bibr" rid="ref44">44</xref>]. Both models integrate traditional motivational theories such as the theory of planned behavior [<xref ref-type="bibr" rid="ref45">45</xref>] or Bandura’s social cognitive theory [<xref ref-type="bibr" rid="ref46">46</xref>]. Since the UTAUT is more differentiated regarding predictors on acceptance and has recently been used in similar research questions [<xref ref-type="bibr" rid="ref38">38</xref>-<xref ref-type="bibr" rid="ref41">41</xref>], we adapted this model to the following study. The UTAUT postulates 4 core predictors of behavioral intention: performance expectancy (expected benefit of technology use), effort expectancy (expected ease of use), social influence (attitude of significant others toward using the technology), and facilitating conditions (organizational or technical resources and preconditions necessary to technology use). In previous studies, performance expectancy proved to be the most important predictor of eHealth acceptance [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref48">48</xref>]. In a meta-analysis of 37 studies testing the UTAUT in various contexts, Taiwo and Downe [<xref ref-type="bibr" rid="ref48">48</xref>] found a medium aggregated effect size of correlation with acceptance (z-transformed r=.54) and somewhat smaller effect sizes for the remaining model predictors (.38-.44).</p>
        <p>However, research also points out the complex nature of acceptance and its determinants [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref43">43</xref>]. Therefore, the predictive model of eHealth acceptance needs to be extended and adapted to the context of different target groups. Typically, sociodemographic characteristics such as younger age, higher educational level, Internet access, and technical experience have been associated with acceptance of eHealth interventions in several studies [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref50">50</xref>]. Further potential barriers to acceptance include Internet anxiety [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref51">51</xref>], low Internet orientation in health problems [<xref ref-type="bibr" rid="ref27">27</xref>], insufficient knowledge of eHealth interventions [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref52">52</xref>], rural residence [<xref ref-type="bibr" rid="ref53">53</xref>], or reservations regarding data security or impersonal interaction [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]. However, barriers or facilitators to eHealth adoption in inpatient routine care have not been studied sufficiently yet.</p>
      </sec>
      <sec>
        <title>Goals of This Study</title>
        <p>This study aimed to (1) determine the current status of acceptance of Web-based aftercare with a focus on work-related stress and (2) explore its drivers and barriers based on an extended UTAUT model in a mixed sample of inpatients in a cross-sectional survey. Besides previously studied Internet-related predictors, we were interested in the influence of eHealth literacy, which is defined as the ability to find, evaluate, and utilize Internet-based health information to deal with health problems [<xref ref-type="bibr" rid="ref56">56</xref>]. Furthermore, we aimed to extend existing literature on the role of self-efficacy [<xref ref-type="bibr" rid="ref57">57</xref>] in the eHealth context. Since the evidence on the influence of symptom severity and uptake of e-mental health interventions is mixed [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref58">58</xref>], we aimed to explore the relation of mental and occupational distress with acceptance. Also, since modern technologies increase digital load and availability [<xref ref-type="bibr" rid="ref59">59</xref>], we were interested in the impact of stress due to constant availability (email, social media) on acceptance.</p>
        <p>We postulated positive relations between UTAUT- and Internet-related predictors as well as self-efficacy. We assumed that Internet anxiety and stress through permanent availability would be negatively associated with acceptance ratings. Furthermore, we investigated subgroup-specific differences. Here, we expected younger age, higher educational status, and urban residency to be associated with higher acceptance.</p>
      </sec>
    </sec>
    <sec sec-type="method">
      <title>Methods</title>
      <sec>
        <title>Study Design</title>
        <p>A cross-sectional approach was adopted to compare acceptance and its predictors in different inpatient diagnostic groups with a self-administered questionnaire. The survey was based on a qualitative pilot study, in which inpatients of various diagnostic groups were interviewed on health-related Internet use and barriers or resources to eHealth utilization in semistructured interviews. The questionnaires were built upon previous findings on predictors of acceptance, which were adapted to this study. In a consensual approach, the content, clarity, and face validity of the items were appraised by internal and external researchers and pretested in one of the cooperation clinics. The survey was conducted in 4 inpatient rehabilitation centers of the German statutory pension insurance scheme, covering a broad range of the most common diagnostic groups: psychosomatic medicine and psycho-oncology (PSY), orthopedics (OPE), cardiology (CAR), pediatric disorders of adolescent patients (PED), and substance use disorders (SUD).</p>
      </sec>
      <sec>
        <title>Participants and Recruitment</title>
        <p>Participants were recruited consecutively by 4 research assistants from August 2015 to January 2016. Participants were required to be aged 14 or above due to ethical rules. Inpatients with at least two weeks of treatment or half of treatment completed were included in the study. Since the focus on work-related stress in Web-based aftercare, retired patients were excluded from further analyses. Of 977 eligible patients who received a questionnaire, 374 (38.3%) responded. Participants were first informed at admission (eg, in an introductory course or at intake) and recruited subsequent to a regular group screening prior to discharge. After oral and written information, patients could fill out the paper-pencil questionnaire. The survey contained 69 questions (59 in pediatric sample, as items regarding occupational aspects were omitted) and took about 15 minutes to fill out. The survey was completely anonymous. No written consent was needed for participants older than 15 years. However, 14-year-old participants and their parents had to fill out a written consent. Gift cards served as an incentive for participation. Participants who wanted to take part in the draw of the gift cards could leave their contact details, which were detached from the questionnaire and kept separately and inaccessible to the project manager to ensure anonymity. All procedures involved in the study were approved by the ethics committee of the Federal State of Rhineland Palatinate, Germany (Ref. No. 9434-F) and the data protection commissioner of the German statutory pension insurance scheme.</p>
      </sec>
      <sec>
        <title>Measures</title>
        <sec>
          <title>Primary Outcome: Acceptance of Web-Based Aftercare</title>
          <p>Based on the UTAUT [<xref ref-type="bibr" rid="ref23">23</xref>], acceptance was operationalized as the intention to use Web-based aftercare. Acceptance was measured using 3 items (<xref ref-type="table" rid="table1">Table 1</xref>). All items were rated on 5-point Likert scales ranging from (1) “totally disagree” to (5) “totally agree,” with higher scores indicating elevated acceptance. The items were adapted from previous studies [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref38">38</xref>-<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref47">47</xref>]. Following a short introduction with general information about Web-based aftercare, the prefix to all items was “A Web-based aftercare for the management of work-related stress...” (for adolescent patients: “Aftercare delivered over the Internet...”). Reliability was calculated as Cronbach alpha. To avoid underestimation of true reliability, the internal consistency of 2-item subscales was not calculated [<xref ref-type="bibr" rid="ref60">60</xref>]. Cronbach alpha of the acceptance scale in this study was .85.</p>
          <table-wrap position="float" id="table1">
            <label>Table 1</label>
            <caption>
              <p>Adapted items of the UTAUT model and references of original studies.</p>
            </caption>
            <table width="569" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
              <col width="100"/>
              <col width="300"/>
              <thead>
                <tr valign="top">
                  <td>Variable</td>
                  <td>Items</td>
                </tr>
              </thead>
              <tbody>
                <tr valign="top">
                  <td>Behavioral Intention</td>
                  <td>“I would like to try a Web-based aftercare.”<sup>a,b,c</sup></td>
                </tr>
                <tr valign="top">
                  <td><break/></td>
                  <td>“I would use a Web-based aftercare if offered to me.”<sup>a,b,c</sup></td>
                </tr>
                <tr valign="top">
                  <td><break/></td>
                  <td>“A Web-based aftercare would be worth paying for.”<sup>a,b,c</sup></td>
                </tr>
                <tr valign="top">
                  <td>Social influence</td>
                  <td>“People close to me would approve a Web-based aftercare.”<sup>a,b,c,d</sup></td>
                </tr>
                <tr valign="top">
                  <td><break/></td>
                  <td>“My general practitioner would approve the use of a Web-based aftercare.”<sup>a,b,c</sup></td>
                </tr>
                <tr valign="top">
                  <td><break/></td>
                  <td>“My friends would approve a Web-based aftercare.”<sup>e</sup></td>
                </tr>
                <tr valign="top">
                  <td>Performance expectancy</td>
                  <td>“A Web-based aftercare could improve my work-related well-being.”<sup>a,b,c</sup></td>
                </tr>
                <tr valign="top">
                  <td><break/></td>
                  <td>“A Web-based aftercare could help me with work-related stress.”<sup>a,b,c</sup></td>
                </tr>
                <tr valign="top">
                  <td><break/></td>
                  <td>“A Web-based aftercare could help me to improve my personal health.”<sup>a,b,c,e</sup></td>
                </tr>
                <tr valign="top">
                  <td><break/></td>
                  <td>“A Web-based aftercare could help me with my health problems.”<sup>a,b,c,e</sup></td>
                </tr>
                <tr valign="top">
                  <td>Effort expectancy</td>
                  <td>“A Web-based aftercare would be easy to operate and comprehend.”<sup>a,b,c,d,f</sup></td>
                </tr>
                <tr valign="top">
                  <td><break/></td>
                  <td>“I could arrange using a Web-based aftercare in my everyday life.”<sup>g</sup></td>
                </tr>
                <tr valign="top">
                  <td>Facilitating conditions</td>
                  <td>“I have the necessary technical preconditions for using a Web-based aftercare.”<sup>a,b,c,d</sup></td>
                </tr>
                <tr valign="top">
                  <td><break/></td>
                  <td>“I possess the required technical knowledge to utilize a Web-based aftercare.”<sup>c,d,f</sup></td>
                </tr>
              </tbody>
            </table>
            <table-wrap-foot>
              <fn id="table1fn1">
                <p><sup>a</sup>Baumeister et al [<xref ref-type="bibr" rid="ref38">38</xref>].</p>
              </fn>
              <fn id="table1fn2">
                <p><sup>b</sup>Baumeister et al [<xref ref-type="bibr" rid="ref39">39</xref>].</p>
              </fn>
              <fn id="table1fn3">
                <p><sup>c</sup>Ebert et al [<xref ref-type="bibr" rid="ref40">40</xref>].</p>
              </fn>
              <fn id="table1fn4">
                <p><sup>d</sup>Venkatesh et al [<xref ref-type="bibr" rid="ref23">23</xref>].</p>
              </fn>
              <fn id="table1fn5">
                <p><sup>e</sup>Items used in the adolescent sample (PED).</p>
              </fn>
              <fn id="table1fn6">
                <p><sup>f</sup>Liu et al [<xref ref-type="bibr" rid="ref47">47</xref>].</p>
              </fn>
              <fn id="table1fn7">
                <p><sup>g</sup>Self-constructed.</p>
              </fn>
            </table-wrap-foot>
          </table-wrap>
        </sec>
        <sec>
          <title>Secondary Outcome: Predictors of Acceptance</title>
          <p>The UTAUT predictors were measured using 2 items each, adapted from previous studies [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref38">38</xref>-<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref47">47</xref>]. Answers were rated on a 5-point Likert scale ranging from from (1) “totally disagree” to (5) “totally agree.” The items of the UTAUT predictors used in the questionnaire and the original studies they were adapted from are listed in <xref ref-type="table" rid="table1">Table 1</xref>.</p>
          <p>Further differential factors were included: <italic>knowledge of eHealth interventions</italic> was measured in 2 items following a short explanation of eHealth interventions based on a previous study by Ebert et al [<xref ref-type="bibr" rid="ref40">40</xref>]. Two items measuring <italic>Internet anxiety</italic> were adapted from previous studies [<xref ref-type="bibr" rid="ref38">38</xref>-<xref ref-type="bibr" rid="ref40">40</xref>]. Answers were rated analogous on a 5-point Likert scale ranging from (1) “totally disagree” to (5) “totally agree.” The frequency (from [1] “never” to [5] “always”) of <italic>health-related Internet and mobile use</italic> was evaluated for different applications (fitness, vital parameters, nutrition, mental and occupational problems). <italic>Self-efficacy</italic> was assessed with the German general self-efficacy short form (ASKU) [<xref ref-type="bibr" rid="ref61">61</xref>], consisting of 3 items with responses rated on a 5-point Likert-type scale ranging from (1) “does not apply at all” to (5) “applies completely.” The questionnaire has proven to be reliable with alpha=.81 to .86 [<xref ref-type="bibr" rid="ref62">62</xref>]. Cronbach alpha in this study was .89.</p>
          <p><italic>eHealth literacy</italic> was measured with the German adaption of the eHealth literacy scale (eHEALS) [<xref ref-type="bibr" rid="ref63">63</xref>], consisting of 8 items. Answers were rated on a 5-point Likert scale ranging from (1) “strongly disagree” to (5) “strongly agree.” Previous research by Norman et al [<xref ref-type="bibr" rid="ref64">64</xref>] showed a high internal consistency of .88. For economic reasons, the questionnaire for adolescent patients included only 3 items of the eHEALS. Items were selected regarding linguistic appropriateness for the target population and high factorial loadings [<xref ref-type="bibr" rid="ref63">63</xref>]. Cronbach alpha of the original scale in this study was .95.</p>
          <p><italic>Mental distress</italic> was assessed with the Patient Health Questionnaire-4 (PHQ-4) as a brief screening instrument for depression and anxiety [<xref ref-type="bibr" rid="ref65">65</xref>] in the adult patient sample. In 4 items with answers on a 4-point scale ranging from 0 (“Not at all) to 3 (“Nearly every day”), the extent of symptoms in the last 2 weeks was evaluated. Sum scores can be categorized as normal (0-2), mild (3-5), moderate (6-8), and severe (9-12) [<xref ref-type="bibr" rid="ref65">65</xref>]. Cronbach alpha in this study was .93.</p>
          <fig id="figure1" position="float">
            <label>Figure 1</label>
            <caption>
              <p>Research model based on the UTAUT (left) and extended predictors (right). UTAUT: unified theory of acceptance and use of technology.</p>
            </caption>
            <graphic xlink:href="jmir_v18i12e337_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
          <p>Furthermore, we measured the <italic>subjective risk of incapacity to work</italic> with the 3-item subjective prognosis of work ability scale (SPE) [<xref ref-type="bibr" rid="ref66">66</xref>] in adult participants. Answers were dichotomized, and sum scores ranged from 0 to 3. Probability of retirement doubles with each scale interval [<xref ref-type="bibr" rid="ref67">67</xref>]. Cronbach alpha in this study was .70. Additionally, the influence of <italic>IT-literacy</italic> [answers ranging from (1) “very little knowledge” to (5) “very good knowledge”] and <italic>stress through permanent availability</italic> (level of agreement on a 5-point Likert-type scale from [1] “strongly disagree” to [5] “strongly agree”) on acceptance were examined in self-constructed items.</p>
          <p>To further explore preconditions of intended usage, participants could state subjective advantages or disadvantages of using a Web-based aftercare. Finally, 1 item measured preferences for different forms of Internet-based support. The research model is depicted in <xref ref-type="fig" rid="figure1">Figure 1</xref>.</p>
        </sec>
        <sec>
          <title>Sociodemographic Characteristics</title>
          <p>The survey contained items regarding sex, age, education or current school type, population of residence, Internet access, time spent on Internet in free time per day, occupational status prior to rehabilitation, and days on sick leave (from [1] “less than 9 days” to [5] “100-365 days”) from the Work Ability Index [<xref ref-type="bibr" rid="ref68">68</xref>]. One item differentiating between types of experience with eHealth interventions was adapted from a previous study by Eichenberg et al [<xref ref-type="bibr" rid="ref27">27</xref>].</p>
        </sec>
      </sec>
      <sec>
        <title>Statistical Analyses</title>
        <p>The data were analyzed using SPSS Statistics version 23 (IBM). Out of 374 datasets, 18 individuals with missing values exceeding 50% (mean 77.73% missing, SD 17.37) were excluded from further analysis [<xref ref-type="bibr" rid="ref69">69</xref>]. Furthermore, 18 individuals who indicated being retired were excluded, resulting in 338 participants analyzed. We addressed missing data under the assumption of data missing at random with multiple imputation technique in SPSS including all analysis variables [<xref ref-type="bibr" rid="ref62">62</xref>]. To demonstrate the extent of missing data, sociodemographic statistics (<xref ref-type="app" rid="app2">Multimedia Appendix 2</xref>) were calculated with observed data, whereas further analyses were based on imputed values (0.6%-15.7% missing values per variable). Imputed statistics were comparable to observed statistics. Group differences of demographics, primary, and secondary outcomes were analyzed using the chi-square test or G-test, analysis of variance with post-hoc comparisons (Games-Howell), or independent <italic>t</italic> tests. In case of variance inhomogeneity, Welch F-ratio was calculated. Acceptance scores were further categorized by mean to describe low (1-2.34), moderate (2.35-3.67), and high (3.68-5) acceptance, and frequency of categories was calculated. The predictive model of acceptance was tested using multiple hierarchical regression. Predictors were included blockwise: (1) sociodemographic and background variables (mental and occupational distress, self-efficacy), (2) Internet-related variables, and (3) UTAUT predictors. According to Midi, Sarkar, and Rana [<xref ref-type="bibr" rid="ref70">70</xref>], no sign of severe multicollinearity could be detected and all predictors could enter the regression. To perform further between-group comparisons of acceptance, mental distress and risk of incapacity to work were dichotomized with a median split. Open answers regarding advantages and disadvantages of Web-based aftercare were rated according to qualitative content analysis [<xref ref-type="bibr" rid="ref71">71</xref>] by 2 independent raters following a-priori consensually developed categories. An inter-rater reliability analysis using Cohen kappa statistic was performed to evaluate consistency.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Sociodemographic Characteristics</title>
        <p>General characteristics of 374 participants are shown in <xref ref-type="app" rid="app2">Multimedia Appendix 2</xref>. More men than women participated in the study, and mean age was 45.49 years (SD 14.17, min 14, max 78). The age range of the pediatric subsample was 14-18 years. The majority of adult inpatients indicated being employed prior to treatment. Educational status was moderate overall. A total of 59 (16.7%, 59/353) participants stated prior eHealth use. Significant differences between diagnostic groups were found in all sociodemographic variables with exception to the distribution of wearables and prior e-mental health usage, primarily in comparison to the pediatric subsample.</p>
      </sec>
      <sec>
        <title>Acceptance of Web-Based Aftercare</title>
        <p>Acceptance of Web-based aftercare was overall low in patients with a mean of 2.56 (SD 1.23). The highest acceptance was found in pediatric patients with a mean of 3.46 (SD 1.42), the lowest in orthopedic patients with a mean of 2.18 (SD 1.00). The diagnostic groups differed statistically significantly (Welch <italic>F</italic><sub>4,133.10</sub>=7.77, <italic>P</italic>&#60;.001). Post-hoc comparisons demonstrated significant differences in all disorder groups compared with the pediatric patients, but not between other diagnostic groups. When including sociodemographic variables as covariates, diagnostic group differences remained marginally significant (<italic>F</italic><sub>4, 326</sub>=2.41, <italic>P</italic>=.05). Acceptance between diagnostic groups is depicted in <xref ref-type="fig" rid="figure2">Figure 2</xref>.</p>
        <p>Further analyses revealed that 48.8% (165/338) could be categorized with a low, 32.8% (111/338) with a moderate, and 18.4% (62/338) with a high acceptance. This pattern only differed in cardiological (42% [28/67] “low,” 48% [32/67] “moderate,” 10% [7/67] “high”) and pediatric patients (22% [11/51] “low,” 24% [12/51] “moderate,” 55% [28/51] “high”). Only 10.2% (31/305) participants with valid answers agreed that they would be willing to pay for participation in a Web-based aftercare.</p>
        <p>Acceptance differed significantly between age groups (<italic>F</italic><sub>3,342</sub>=9.97, <italic>P</italic>&#60;.001) with highest acceptance in the youngest quartile (14-26 years). Post-hoc tests revealed significant differences between the youngest and all other age groups. Further data inspection of sociodemographic variables revealed no differences in acceptance regarding gender, population of residence, and occupational status. However, prior eHealth use, higher educational status, and private Internet access were associated with higher acceptance. <xref ref-type="table" rid="table2">Table 2</xref> contains acceptance scores as a function of demographics.</p>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>Acceptance (means) of Web-based aftercare between diagnostic groups. Sample size in brackets. Error bars represent standard deviations.</p>
          </caption>
          <graphic xlink:href="jmir_v18i12e337_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Differences in acceptance by demographics (N=338).</p>
          </caption>
          <table width="584" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="10"/>
            <col width="100"/>
            <col width="100"/>
            <col width="100"/>
            <col width="100"/>
            <col width="100"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Variable</td>
                <td>n</td>
                <td>Mean (SD)</td>
                <td>Test</td>
                <td><italic>P</italic> value</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="5"><bold>Sex</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Male</td>
                <td>198</td>
                <td>2.62 (1.21)</td>
                <td><italic>t</italic><sub>336</sub>=0.93</td>
                <td>.35</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Female</td>
                <td>140</td>
                <td>2.49 (1.26)</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td colspan="5"><bold>Age in years</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>14-26</td>
                <td>57</td>
                <td>3.34 (1.42)</td>
                <td><italic>F</italic><sub>3,334</sub>=9.57</td>
                <td><italic>P</italic>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>27-39</td>
                <td>32</td>
                <td>2.40 (1.18)</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>40-52</td>
                <td>130</td>
                <td>2.41 (1.11)</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>53-65</td>
                <td>119</td>
                <td>2.40 (1.23)</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td colspan="5"><bold>Educational status</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>No graduation</td>
                <td>10</td>
                <td>1.95 (1.04)</td>
                <td><italic>F</italic><sub>2,335</sub>=8.00</td>
                <td><italic>P</italic>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Secondary school</td>
                <td>277</td>
                <td>2.48 (1.18)</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>A-level</td>
                <td>51</td>
                <td>3.14 (1.38)</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td colspan="5"><bold>eHealth experience</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Yes</td>
                <td>56</td>
                <td>2.44 (1.20)</td>
                <td>Mann-Whitney <italic>U</italic>=5315</td>
                <td><italic>P</italic>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>No</td>
                <td>282</td>
                <td>3.16 (1.24)</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td colspan="5"><bold>Internet access</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Yes</td>
                <td>296</td>
                <td>2.65 (1.23)</td>
                <td><italic>t</italic><sub>336</sub>=−3.60</td>
                <td><italic>P</italic>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>No</td>
                <td>42</td>
                <td>1.98 (1.11)</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td colspan="5"><bold>Occupational status</bold> (287)<sup>a</sup></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Employed</td>
                <td>195</td>
                <td>2.43 (1.13)</td>
                <td><italic>F</italic><sub>2,284</sub>=0.41</td>
                <td>.66</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Unemployed</td>
                <td>44</td>
                <td>2.26 (1.11)</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Sick leave</td>
                <td>48</td>
                <td>2.42 (1.14)</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td colspan="5"><bold>Population of residence</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Rural</td>
                <td>145</td>
                <td>2.53 (1.27)</td>
                <td><italic>t</italic><sub>336</sub>=−0.41</td>
                <td>.68</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Urban</td>
                <td>193</td>
                <td>2.59 (1.21)</td>
                <td> </td>
                <td><break/></td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table2fn1">
              <p><sup>a</sup>Retired and adolescent patients (PED) excluded.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Drivers and Barriers to Acceptance</title>
        <p>Multiple hierarchical regression in adult inpatients (PSY, OPE, CAR, SUD) showed that out of the demographic and background variables entered in the first step, gender (beta=–0.13, <italic>P</italic>=.04) and Internet access (beta=0.13, <italic>P</italic>=.03) predicted acceptance, although explained variance was low (<italic>R</italic><sup>2</sup>=.06, <italic>F</italic><sub>9,272</sub>=2.09, <italic>P</italic>=.03). When entering Internet-related variables, explained variance increased significantly (<italic>R</italic><sup>2</sup>=.17, <italic>F</italic><sub>17,264</sub>=3.22, <italic>P</italic>&#60;.001), but only health-related Internet and mobile use significantly predicted acceptance (beta=0.22, <italic>P</italic>&#60;.001). The full regressive model including UTAUT variables showed high explained variance (<italic>R</italic><sup>2</sup>=.78, <italic>F</italic><sub>21,260</sub>=43.86, <italic>P</italic>&#60;.001). Social influence (beta=.39, <italic>P</italic>&#60;.001), performance expectancy (beta=.31, <italic>P</italic>&#60;.001), and effort expectancy (beta=.22 <italic>, P</italic>&#60;.001) significantly predicted acceptance, whereas facilitating conditions did not reach significance (<xref ref-type="table" rid="table3">Table 3</xref>). Furthermore, stress through permanent availability (beta=–.09, <italic>P</italic>=.01) could be observed as a fourth significant predictor. <xref ref-type="table" rid="table3">Table 3</xref> contains the regression parameters of the complete regression model.</p>
        <p>In a separate regression analysis of the adolescent subsample (PED), explained variance of acceptance significantly improved in the model including UTAUT-predictors (<italic>R²</italic> = .85, <italic>F</italic><sub>18,32</sub>=10.28, <italic>P</italic>&#60;.001) in comparison to the previous steps (demographic variables only: <italic>R²</italic> = .24, <italic>F</italic><sub>6,44</sub>=2.33, <italic>P</italic>=.05; demographic and Internet-related variables: <italic>R²</italic>=.43, <italic>F</italic><sub>14,36</sub>=1.94, <italic>P</italic>=.06). However, of the UTAUT-predictors, only performance expectancy (beta=.67, <italic>P</italic>&#60;.001) significantly predicted acceptance of Web-based aftercare. Knowledge of eHealth interventions (beta=.21, <italic>P</italic>=.02) and IT literacy (beta=−.22, <italic>P</italic>=.04) proved to be further predictors of acceptance in the full model. The correlation matrix of the total sample can be found in the <xref ref-type="app" rid="app3">Multimedia Appendix 3</xref>. Absolute values of intercorrelations ranged from &#124;0.0&#124; to &#124;0.79&#124;.</p>
        <table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Regression model of acceptance (full model, adult sample, N=282).</p>
          </caption>
          <table width="575" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="10"/>
            <col width="200"/>
            <col width="50"/>
            <col width="80"/>
            <col width="100"/>
            <col width="50"/>
            <col width="50"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Predictor</td>
                <td>b</td>
                <td>Standard error</td>
                <td>95% CI</td>
                <td>Beta</td>
                <td><italic>P</italic> value</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td/>
                <td>Constant</td>
                <td>.08</td>
                <td>.44</td>
                <td>−0.78 to 0.94</td>
                <td> </td>
                <td>.86</td>
              </tr>
              <tr valign="top">
                <td colspan="7"><bold>Sociodemographic predictors</bold></td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Sex</td>
                <td>.03</td>
                <td>.07</td>
                <td>−0.11 to 0.18</td>
                <td>.01</td>
                <td>.64</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Age</td>
                <td>.01</td>
                <td>.00</td>
                <td>0.00 to 0.02</td>
                <td>.05</td>
                <td>.17</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Days on sick leave</td>
                <td>–.01</td>
                <td>.03</td>
                <td>−.0.06 to 0.05</td>
                <td>−.01</td>
                <td>.76</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Internet access</td>
                <td>–.05</td>
                <td>.11</td>
                <td>−0.27 to 0.18</td>
                <td>−.01</td>
                <td>.68</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Population of residence</td>
                <td>–.11</td>
                <td>.07</td>
                <td>−0.25 to 0.03</td>
                <td>−.05</td>
                <td>.12</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Educational status</td>
                <td>–.06</td>
                <td>.09</td>
                <td>−0.24 to 0.11</td>
                <td>−.02</td>
                <td>.49</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Self-efficacy<sup>a</sup></td>
                <td>–.01</td>
                <td>.05</td>
                <td>−0.10 to 0.08</td>
                <td>−.01</td>
                <td>.80</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Mental distress<sup>b</sup></td>
                <td>.01</td>
                <td>.01</td>
                <td>−0.02 to 0.03</td>
                <td>.02</td>
                <td>.66</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Risk of incapacity to work<sup>c</sup></td>
                <td>–.01</td>
                <td>.03</td>
                <td>−0.07 to 0.06</td>
                <td>−.01</td>
                <td>.85</td>
              </tr>
              <tr valign="top">
                <td colspan="7"><bold>Internet-related predictors</bold></td>
              </tr>
              <tr valign="top">
                <td/>
                <td>eHealth literacy<sup>d</sup></td>
                <td>.01</td>
                <td>.06</td>
                <td>−0.10 to 0.12</td>
                <td>.01</td>
                <td>.90</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Internet anxiety</td>
                <td>.02</td>
                <td>.04</td>
                <td>−0.06 to 0.10</td>
                <td>.02</td>
                <td>.67</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Knowledge of eHealth interventions</td>
                <td>–.06</td>
                <td>.04</td>
                <td>−0.14 to 0.02</td>
                <td>−.06</td>
                <td>.14</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Time on Internet</td>
                <td>–.01</td>
                <td>.02</td>
                <td>−0.04 to 0.03</td>
                <td>−.01</td>
                <td>.71</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>eHealth experience</td>
                <td>.18</td>
                <td>.11</td>
                <td>−0.03 to 0.39</td>
                <td>.05</td>
                <td>.09</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Health-related Internet <break/>and mobile use</td>
                <td>.07</td>
                <td>.06</td>
                <td>−0.04 to 0.19</td>
                <td>.04</td>
                <td>.21</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>IT literacy</td>
                <td>.00</td>
                <td>.04</td>
                <td>−0.09 to 0.08</td>
                <td>.00</td>
                <td>.95</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Permanent availability stress</td>
                <td>–.08</td>
                <td>.03</td>
                <td>−0.14 to −0.02</td>
                <td>−.09</td>
                <td>.01</td>
              </tr>
              <tr valign="top">
                <td colspan="7"><bold>UTAUT-predictors</bold></td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Social influence</td>
                <td>.42</td>
                <td>.06</td>
                <td>0.30 to 0.54</td>
                <td>.39</td>
                <td>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Performance expectancy</td>
                <td>.31</td>
                <td>.06</td>
                <td>0.19 to 0.43</td>
                <td>.31</td>
                <td>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Effort expectancy</td>
                <td>.20</td>
                <td>.06</td>
                <td>.0.09 to 0.31</td>
                <td>.22</td>
                <td>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td/>
                <td>Facilitating conditions</td>
                <td>.06</td>
                <td>.05</td>
                <td>−0.03 to 0.16</td>
                <td>.07</td>
                <td>.19</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table3fn1">
              <p><sup>a</sup>General self-efficacy short form (ASKU) [<xref ref-type="bibr" rid="ref61">61</xref>].</p>
            </fn>
            <fn id="table3fn2">
              <p><sup>b</sup>Patient Health Questionnaire-4 (PHQ-4) [<xref ref-type="bibr" rid="ref65">65</xref>].</p>
            </fn>
            <fn id="table3fn3">
              <p><sup>c</sup>Subjective prognosis of work ability scale (SPE) [<xref ref-type="bibr" rid="ref66">66</xref>].</p>
            </fn>
            <fn id="table3fn4">
              <p><sup>d</sup>eHealth literacy scale (eHEALS) [<xref ref-type="bibr" rid="ref63">63</xref>].</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Secondary Outcome</title>
        <p>Overall, eHealth and IT literacy, knowledge of eHealth interventions, and self-efficacy were moderate. Mental distress ranged from “normal” (CAR) to “moderate” (PSY). Risk of incapacity to work was on average. Acceptance did not differ in extreme-group comparisons (PHQ-9: <italic>t</italic><sub>285</sub>=0.54, <italic>P</italic>=.59; SPE: <italic>t</italic><sub>214</sub>=1.48, <italic>P</italic>=.14). Participants reported low health-related Internet or mobile use, with less than 1 in 10 participants who indicated utilization for mental health problems or occupational stress. Significant differences of diagnostic groups were observed in all secondary outcome variables. Secondary outcome is reported in <xref ref-type="table" rid="table4">Table 4</xref>. Post-hoc tests revealed a distinguished role of the pediatric (higher IT literacy, eHealth literacy, eHealth knowledge, eHealth experience, lower ratings on stress through permanent availability, and Internet anxiety) and the psychosomatic subsample (low eHealth literacy, eHealth knowledge, eHealth experience, low self-efficacy, and high Internet anxiety). When including age as a covariate, these group differences remained significant.</p>
        <table-wrap position="float" id="table4">
          <label>Table 4</label>
          <caption>
            <p>Means, standard deviations, and test statistics of group differences for secondary outcome measures (N=338).</p>
          </caption>
          <table width="633" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="120"/>
            <col width="45"/>
            <col width="45"/>
            <col width="45"/>
            <col width="45"/>
            <col width="45"/>
            <col width="45"/>
            <col width="84"/>
            <col width="35"/>
            <thead>
              <tr valign="top">
                <td> Variable</td>
                <td>PSY<sup>a</sup></td>
                <td>OPE<sup>b</sup></td>
                <td>CAR<sup>c</sup></td>
                <td>PED<sup>d</sup></td>
                <td>SUD<sup>e</sup></td>
                <td>Total</td>
                <td><italic>F</italic></td>
                <td><italic>P</italic> value</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Mean (SD)</td>
                <td>Mean (SD)</td>
                <td>Mean (SD)</td>
                <td>Mean (SD)</td>
                <td>Mean (SD)</td>
                <td>Mean (SD)</td>
                <td><break/></td>
                <td><break/></td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Performance expectancy</td>
                <td>2.41 (1.21)</td>
                <td>2.26 (1.09)</td>
                <td>2.59 (1.07)</td>
                <td>3.24 (1.14)</td>
                <td>2.34 (1.06)</td>
                <td>2.54 (1.17)</td>
                <td><italic>F</italic><sub>4,333</sub>=6.23</td>
                <td><italic>P</italic>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td>Effort expectancy</td>
                <td>2.70 (1.29)</td>
                <td>2.60 (1.13)</td>
                <td>2.98 (1.16)</td>
                <td>3.42 (1.03)</td>
                <td>2.57 (1.20)</td>
                <td>2.83 (1.22)</td>
                <td>Welch <italic>F</italic><sub>4,134.92</sub>=5.64</td>
                <td><italic>P</italic>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td>Social influence</td>
                <td>2.52 (1.06)</td>
                <td>2.41 (1.14)</td>
                <td>2.79 (0.96)</td>
                <td>2.87 (0.97)</td>
                <td>2.38 (1.10)</td>
                <td>2.59 (1.05)</td>
                <td><italic>F</italic><sub>4,333</sub>=2.57</td>
                <td>.04</td>
              </tr>
              <tr valign="top">
                <td>Facilitating conditions</td>
                <td>3.09 (1.38)</td>
                <td>2.95 (1.30)</td>
                <td>3.30 (1.19)</td>
                <td>3.98 (1.19)</td>
                <td>2.91 (1.24)</td>
                <td>3.22 (1.32)</td>
                <td><italic>F</italic><sub>4,333</sub>=6.10</td>
                <td><italic>P</italic>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td>eHealth literacy<sup>f</sup></td>
                <td>3.30 (1.00)</td>
                <td>3.63 (0.90)</td>
                <td>3.76 (0.90)</td>
                <td>4.08 (0.73)</td>
                <td>3.37 (1.13)</td>
                <td>3.56 (1.00)</td>
                <td>Welch <italic>F</italic><sub>4,134.52</sub>=9.37</td>
                <td><italic>P</italic>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td>Internet anxiety</td>
                <td>2.57 (1.27)</td>
                <td>2.28 (1.14)</td>
                <td>2.10 (1.28)</td>
                <td>1.87 (1.06)</td>
                <td>2.24 (1.08)</td>
                <td>2.28 (1.22)</td>
                <td><italic>F</italic><sub>4,333</sub>=3.76</td>
                <td><italic>P</italic>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td>Self-efficacy<sup>g</sup></td>
                <td>3.10 (0.91)</td>
                <td>4.07 (0.87)</td>
                <td>4.11 (0.71)</td>
                <td>3.50 (0.99)</td>
                <td>3.67 (0.72)</td>
                <td>3.57 (0.94)</td>
                <td>Welch <italic>F</italic><sub>4,132.09</sub>=20.75</td>
                <td><italic>P</italic>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td>Knowledge of eHealth interventions</td>
                <td>2.43 (1.10)</td>
                <td>3.08 (1.03)</td>
                <td>2.90 (1.03)</td>
                <td>3.28 (1.05)</td>
                <td>2.73 (1.15)</td>
                <td>2.78 (1.12)</td>
                <td><italic>F</italic><sub>4,333</sub>=6.99</td>
                <td><italic>P</italic>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td>Health-related Internet and mobile use</td>
                <td>1.38 (0.55)</td>
                <td>1.51 (0.65)</td>
                <td>1.71 (0.77)</td>
                <td>1.97 (0.86)</td>
                <td>1.55 (0.77)</td>
                <td>1.58 (0.73)</td>
                <td>Welch <italic>F</italic><sub>4,124.91</sub>=6.28</td>
                <td><italic>P</italic>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td>Permanent availability stress</td>
                <td>3.07 (1.37)</td>
                <td>3.03 (1.26)</td>
                <td>2.81 (1.31)</td>
                <td>1.77 (1.08)</td>
                <td>2.72 (1.37)</td>
                <td>2.76 (1.37)</td>
                <td><italic>F</italic><sub>4,333</sub>=9.55</td>
                <td><italic>P</italic>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td>Mental distress<sup>h</sup></td>
                <td>7.34 (3.21)</td>
                <td>3.36 (3.24)</td>
                <td>1.84 (2.29)</td>
                <td>--</td>
                <td>3.21 (2.85)</td>
                <td>4.69 (3.77)</td>
                <td><italic>F</italic><sub>3,283</sub>=61.72</td>
                <td><italic>P</italic>&#60;.001</td>
              </tr>
              <tr valign="top">
                <td>Risk of incapacity to work<sup>i</sup></td>
                <td>1.41 (1.14)</td>
                <td>1.38 (0.95)</td>
                <td>0.89 (1.12)</td>
                <td>-- <break/></td>
                <td>1.07 (1.10)</td>
                <td>1.22 (1.12)</td>
                <td><italic>F</italic><sub>3,278</sub>=3.79</td>
                <td>.01</td>
              </tr>
              <tr valign="top">
                <td>IT literacy</td>
                <td>2.88 (1.19)</td>
                <td>3.02 (1.14)</td>
                <td>3.24 (1.18)</td>
                <td>4.1 (0.76)</td>
                <td>2.93 (1.25)</td>
                <td>3.16 (1.2)</td>
                <td>Welch <italic>F</italic><sub>4,134.68</sub>=19.56</td>
                <td><italic>P</italic>&#60;.001</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table4fn1">
              <p><sup>a</sup>PSY: psychosomatic medicine and psycho-oncology.</p>
            </fn>
            <fn id="table4fn2">
              <p><sup>b</sup>OPE: orthopedics.</p>
            </fn>
            <fn id="table4fn3">
              <p><sup>c</sup>CAR: cardiology.</p>
            </fn>
            <fn id="table4fn4">
              <p><sup>d</sup>PED: pediatric disorders of adolescent patients.</p>
            </fn>
            <fn id="table4fn5">
              <p><sup>e</sup>SUD: substance use disorders.</p>
            </fn>
            <fn id="table4fn6">
              <p><sup>f</sup>eHealth literacy scale (eHEALS) [<xref ref-type="bibr" rid="ref63">63</xref>].</p>
            </fn>
            <fn id="table4fn7">
              <p><sup>g</sup>General self-efficacy short form (ASKU) [<xref ref-type="bibr" rid="ref61">61</xref>]</p>
            </fn>
            <fn id="table4fn8">
              <p><sup>h</sup>Patient Health Questionnaire-4 (PHQ-4) [<xref ref-type="bibr" rid="ref65">65</xref>].</p>
            </fn>
            <fn id="table4fn9">
              <p><sup>i</sup>Subjective prognosis of work ability scale (SPE) [<xref ref-type="bibr" rid="ref66">66</xref>].</p>
            </fn>


          </table-wrap-foot>
        </table-wrap>
        <p>Furthermore, the majority of inpatients with valid answers (n=280) indicated interest in digital health-related information (68.9%, 193/280) and exercises (56.8%, 159/280). Half of the patients were interested in a Web-based expert contact (52.1%, 146/280) and the use of an app for aftercare (37.9%, 106/280). However, most participants with valid answers preferred face-to-face aftercare (53.4%, 179/335) over Web-based aftercare (4.8%, 16/335), 38.2% (128/335) rated Web-based aftercare as an add-on to traditional methods and 3.6% (12/335) had no interest in any form of aftercare (<italic>χ</italic><sup>2</sup><sub>3</sub>=247.99, <italic>P</italic>&#60;.001).</p>
        <p>Inter-rater reliability of open answers on advantages and disadvantages was high (Cohen kappa=.89, <italic>P</italic>&#60;.001, 95% CI 0.54-1). Flexibility in terms of time and location of utilization were rated as main advantages, while impersonality and concerns about data security were perceived as main disadvantages of Web-based aftercare. <xref ref-type="table" rid="table5">Table 5</xref> contains the most frequently reported advantages of 113 and disadvantages of 121 participants.</p>
        <table-wrap position="float" id="table5">
          <label>Table 5</label>
          <caption>
            <p>Advantages and disadvantages of Web-based aftercare as measured by number of statements. Frequencies above 5% reported; infrequent statements aggregated in “others” category.</p>
          </caption>
          <table width="612" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="10"/>
            <col width="245"/>
            <col width="91"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Category</td>
                <td>n (%)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="3"><bold>Advantages (n=152 statements)</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Flexibility in time</td>
                <td>51 (33.6%)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Local flexibility</td>
                <td>33 (21.7%)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Availability of personal support</td>
                <td>11 (7.2%)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Reduced expenditure of time</td>
                <td>9 (5.9%)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Availability and topicality of health <break/>information</td>
                <td>8 (5.3%)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Anonymity</td>
                <td>8 (5.3%)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Other</td>
                <td>32 (21.1%)</td>
              </tr>
              <tr valign="top">
                <td colspan="3"><bold>Disadvantages (n=142 statements)</bold></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Too impersonal</td>
                <td>39 (27.5%)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Concerns about data security</td>
                <td>14 (9.9%)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Increased expenditure of time</td>
                <td>14 (9.9%)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Organizational conflicts</td>
                <td>12 (8.5%)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Insufficient professional supervision</td>
                <td>10 (7.0%)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Insufficient knowledge of Internet use</td>
                <td>10 (7.0%)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>General concerns about Internet use</td>
                <td>8 (5.6%)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Insufficient motivation</td>
                <td>8 (5.6%)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Other</td>
                <td>27 (19.0%)</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>This study examined barriers and motivators to acceptance of Web-based aftercare in a transdiagnostic sample of inpatients building upon the UTAUT [<xref ref-type="bibr" rid="ref23">23</xref>] and explored subgroup-specific effects.</p>
        <p>The results indicated a rather low level of acceptance of Web-based aftercare for work-related stress. Taken together, 81.6% of the patients reported a low-to-moderate acceptance, which was comparable to previous findings in different clinical settings, such as inpatient diabetic [<xref ref-type="bibr" rid="ref38">38</xref>], chronic pain [<xref ref-type="bibr" rid="ref39">39</xref>], or primary care patients [<xref ref-type="bibr" rid="ref40">40</xref>], and evidence from surveys in the general population [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref27">27</xref>]. Interestingly, acceptance ratings for Web-based aftercare were lower compared to uptake rates of face-to-face-aftercare [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref9">9</xref>]. This was confirmed by a clear face-to-face treatment preference of inpatients in this study, which corresponded to evidence from previous studies [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref72">72</xref>]. Despite growing evidence on the efficacy of eHealth interventions [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref2">2</xref>], acceptance in target groups seems limited, which points to different drivers and barriers to eHealth acceptance and adoption. However, high acceptance, eHealth literacy, and Internet-orientation in younger patients suggest sufficient resources to eHealth implementation in adolescent care. Since the incidence rates of mental disorders in adolescents are quite high [<xref ref-type="bibr" rid="ref73">73</xref>], eHealth interventions thus seem promising in preventing or treating mental health problems.</p>
        <p>This study supported the viability of the UTAUT model in assessing acceptance and found that social influence, performance, and effort expectancy, as well as stress through permanent availability, predicted acceptance. These factors may provide a framework for improving acceptance and implementation of eHealth interventions in inpatient rehabilitation.</p>
        <p>The effect of <italic>social influence</italic> on acceptance was prominent, in contrast to some previous evidence, where this predictor reached smaller effects [<xref ref-type="bibr" rid="ref48">48</xref>]. The influence of significant others in eHealth acceptance (family, friends, general practitioner) thus underlines the systemic aspect of the person-environment interaction in clinical settings. A positive attitude of significant others about eHealth efficacy and practitioners’ willingness to refer these programs can foster adoption and adherence in patients. In particular, general practitioners may play an important role as gate keepers to eHealth adoption [<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref75">75</xref>]. A study by van Voorhees et al [<xref ref-type="bibr" rid="ref75">75</xref>] could demonstrate, for example, that uptake of a e-mental health intervention increased with client-centered information by clinicians, targeting intrinsic motivation. Therefore, facilitation of acceptance needs to include relevant stakeholders of health care (eg, practitioners, clinicians, administrators) as important mediators of eHealth implementation.</p>
        <p>In line with previous research [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref48">48</xref>], we identified <italic>performance expectancy</italic> as a key predictor of acceptance, with negative outcome expectations predicting lower intention of utilization. Similarly, research suggests that performance expectancy may also be a predictor of treatment outcome in psychotherapy [<xref ref-type="bibr" rid="ref76">76</xref>]. However, the disparity between low performance expectancy and actual efficacy of eHealth interventions [<xref ref-type="bibr" rid="ref2">2</xref>] supports the need for further, transparent eHealth education, targeting common misconceptions, for example, about inferior efficacy in contrast to traditional therapies [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref72">72</xref>].</p>
        <p>The influence of <italic>effort expectancy</italic> reflects the importance of a fit of usability and adoption in everyday life. This corroborates prior research, suggesting that incongruity of organization and scheduling of aftercare sessions with working life are key aspects of participation rate [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref35">35</xref>]. It seems that mechanisms of uptake are, to some extent, comparable between Web-based and face-to-face treatment. However, technical barriers and concerns about data security or impersonality as well as facilitators such as flexibility or anonymity are unique to eHealth interventions. Usability may relate to eHealth literacy as well [<xref ref-type="bibr" rid="ref77">77</xref>], which was above average in this study and comparable to previous research in a student population [<xref ref-type="bibr" rid="ref63">63</xref>]. However, future studies should expand the concept of eHealth literacy by investigating the ability to utilize eHealth interventions.</p>
        <p>Interestingly, <italic>stress through permanent availability</italic> was associated with a lower acceptance, although the effect was very small. It would seem that Web-based aftercare may raise concerns about privacy or technological weariness in coping with health problems. In a qualitative study, Donkin and Glozier [<xref ref-type="bibr" rid="ref78">78</xref>] identified technology fatigue as an important barrier to adherence to e-mental health interventions. A German survey of 538 employees found that 88% stated being reachable to clients or coworkers, and that 42% could not recognize a clear boundary between professional and private life [<xref ref-type="bibr" rid="ref79">79</xref>]. Moreover, Reinecke et al [<xref ref-type="bibr" rid="ref59">59</xref>] found that digital communication load was associated with burnout, depression, and anxiety in a representative survey. However, further studies are recommended to develop a full picture of the association between eHealth utilization, experience of stress through availability, and other sources of occupational stress.</p>
        <p>Furthermore, our data show a differential influence of <italic>demographics</italic>, with a pattern of higher acceptance in younger, more educated, and eHealth literate patients with private Internet access and those with eHealth experience. This pattern confirms previous evidence on a relationship with Internet use [<xref ref-type="bibr" rid="ref80">80</xref>], Internet competence [<xref ref-type="bibr" rid="ref81">81</xref>], and acceptance of e-mental health interventions [<xref ref-type="bibr" rid="ref27">27</xref>]. It may be that these mediate the influence of Internet affinity and prior use of eHealth interventions on acceptance. However, we could not find a continuous relation of acceptance and age. Nevertheless, our data point to a “digital divide” in eHealth adoption that may reflect existing social barriers to education or health promotion [<xref ref-type="bibr" rid="ref82">82</xref>,<xref ref-type="bibr" rid="ref83">83</xref>]. A recent survey, for example, revealed that only 30% of Germans older than 60 years used the Internet on a regular basis [<xref ref-type="bibr" rid="ref80">80</xref>]. In this regard, Renahy et al [<xref ref-type="bibr" rid="ref83">83</xref>] criticized limited access to eHealth not only in old aged but also in chronically ill patients. Future research should therefore aim to facilitate access and education and to adapt eHealth interventions to undersupplied or risk groups in particular.</p>
        <p>However, other predictors did not prove to be relevant barriers or resources to eHealth acceptance in our sample. It would seem that a technical infrastructure is widely available and accessible to the majority of inpatients. As previously noted, attitudes may have a greater impact compared with structural barriers on utilization and adherence of eHealth interventions, in particular with ongoing technical progress [<xref ref-type="bibr" rid="ref25">25</xref>]. However, eHealth intervention knowledge, eHealth experience, and health-related Internet and mobile use were low in most inpatients in our study. This can be applied to health professionals too, where previous studies found that only few practitioners offer e-mental health interventions to patients [<xref ref-type="bibr" rid="ref84">84</xref>,<xref ref-type="bibr" rid="ref85">85</xref>], thus limiting availability and exposure to effective treatment tools. Perle et al [<xref ref-type="bibr" rid="ref52">52</xref>] found that 75% of clinical psychologists would reconsider using a Web camera–based e-mental health intervention after appropriate education. However, eHealth training for health professionals is scarce. When considering methods to facilitate acceptance, initial evidence in different target groups suggests that a brief video-based introduction or interactive presentation containing information about effectiveness, data security, or advantages of eHealth interventions can be an economic way to facilitate acceptance and resources to eHealth adoption [<xref ref-type="bibr" rid="ref38">38</xref>-<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]. Recently, Donovan et al [<xref ref-type="bibr" rid="ref87">87</xref>] provided promising, yet mixed, evidence for a PowerPoint-based eHealth education in mental health professionals. However, further work is required to establish the viability of eHealth training and acceptance facilitation in different clinical contexts such as inpatient rehabilitation and to enhance familiarity and experience with eHealth interventions.</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>Despite the strengths of our study, several limitations should be considered when interpreting the results. First, since we adapted items to the specific context of our study, psychometric validity cannot be fully ensured. To maintain parsimony, some predictors were operationalized with only 2 items, limiting their reliability. Also, differences in diagnostic groups may partly reflect diverging areas of application of Web-based aftercare between the adolescent and the adult populations. Future designs should increase item quantity to improve reliability of measurement and perform confirmatory factor or moderator analyses with larger sample sizes.</p>
        <p>Second, the generalizability to other samples might be limited due to possible selection effects and diverging recruitment efficacy. This is reflected in a low overall response rate, ranging from 26% to 100% between facilities. In a way, the response rate may also represent an indicator of low acceptance of eHealth interventions. Furthermore, a large proportion of adult participants (36.4%) were not working before treatment, which might have limited acceptance of work-related interventions. Moreover, small sample sizes of some subgroup analyses (eg, diagnostic group comparisons, open answers) need to be considered. However, we were able to investigate a broad range of the most common diagnostic groups of German inpatient rehabilitation [<xref ref-type="bibr" rid="ref88">88</xref>] without preselection of Internet-oriented individuals. Our study relied on a well-established theoretical model and validated secondary outcome measures and proved their reliability in, and applicability to, a mixed inpatient sample. However, future research should promote reliable instruments of acceptance evaluation in different contexts. The aforementioned APOI [<xref ref-type="bibr" rid="ref37">37</xref>] found the factors “Scepticism and Perception of Risks,” “Confidence in Effectiveness” (similar to performance expectancy), “Technologization Threat” (similar to stress through constant availability), and “Anonymity Benefits” (p. 140) as dimensions of attitudes toward e-mental-health interventions. Moreover, Boß et al [<xref ref-type="bibr" rid="ref89">89</xref>] recently adapted the Client Satisfaction Questionnaire [<xref ref-type="bibr" rid="ref90">90</xref>] to eHealth interventions. Also, Mohr et al [<xref ref-type="bibr" rid="ref91">91</xref>] developed a 24-item questionnaire measuring perceived barriers to psychological treatment, which could be adapted to the context of eHealth interventions. Prospectively, these could also provide clinicians with reliable and valuable information in the implementation of eHealth interventions in practice.</p>
        <p>Third, it should be noted that in line with previous studies, we measured acceptance as behavioral intention, which allows only for a prediction but not for direct translation into actual use behavior, given the well-known intention-behavior gap [<xref ref-type="bibr" rid="ref92">92</xref>]. Future research should therefore include uptake rate as an outcome measure to improve interpretability of motivational aspects and allow for a direct comparison of utilization of Web-based and face-to-face aftercare. Fourth, not only motivational but also structural barriers to eHealth adoption need to be considered when investigating acceptance. Institutional or technical constraints may limit application of eHealth interventions [<xref ref-type="bibr" rid="ref93">93</xref>]. In Germany and other countries, the use of eHealth interventions still underlies legal constraints, requiring at least an initial face-to-face contact with practitioners. Thus, even if willingness to use eHealth interventions was higher, uptake could be limited by such macro-level constraints.</p>
        <p>Finally, the cross-sectional design of the study does not allow for a direct projection to further technical developments and progress of implementation of eHealth interventions. Longitudinal designs will be needed to accompany technical progress and change in underlying barriers and facilitators to acceptance.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>Our study contributes to the exploration of barriers and drivers to eHealth implementation in inpatient treatment and illustrates a limited but developable acceptance. Our results suggest that expectations on efficacy and usability, social norms, and experience of permanent availability modulate acceptance of Web-based aftercare. Thus, it seems critical not only to increase eHealth experience and literacy but to facilitate positive attitudes and target misconceptions about eHealth interventions, regarding competitiveness to face-to-face treatment, effectiveness, individuality, or therapeutic relationship. More elaborate forms of education and quality assurance in implementation are needed, for example, with the development of mandatory and comprehensible quality criteria or training in the application of eHealth interventions for health professionals. Future developments of eHealth interventions therefore should include patients as well as other stakeholders in a collaborative approach to allow for a better conjunction between technical, contextual, and motivational factors influencing adoption and effectiveness of eHealth interventions.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <app id="app1">
        <title>Multimedia Appendix 1</title>
        <p>Exemplary description of different Web-based aftercare interventions following inpatient treatment.</p>
        <media xlink:href="jmir_v18i12e337_app1.xlsx" xlink:title="XLSX File (Microsoft Excel File), 14KB"/>
      </app>
      <app id="app2">
        <title>Multimedia Appendix 2</title>
        <p>Characteristics of the sample.</p>
        <media xlink:href="jmir_v18i12e337_app2.xlsx" xlink:title="XLSX File (Microsoft Excel File), 17KB"/>
      </app>
      <app id="app3">
        <title>Multimedia Appendix 3</title>
        <p>Correlation matrix of acceptance predictors.</p>
        <media xlink:href="jmir_v18i12e337_app3.xlsx" xlink:title="XLSX File (Microsoft Excel File), 15KB"/>
      </app>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>


        <def-item>
          <term id="abb2">ASKU</term>
          <def>
            <p>general self-efficacy short form</p>

</def></def-item>
        <def-item>
          <term id="abb3">CAR</term>
          <def>
            <p>cardiology</p>
          </def>
</def-item>
        <def-item>
          <term id="abb4">CBT</term>
          <def>
            <p>cognitive behavioral therapy</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">eHEALS</term>
          <def>
            <p>eHealth literacy scale</p>
          </def>
        </def-item>

        <def-item>
          <term id="abb6">OPE</term>
          <def>
            <p>orthopedics</p>
          </def>
        </def-item>



        <def-item>
          <term id="abb7">PED</term>
          <def>
            <p>pediatric disorders of adolescent patients</p>
          </def>
        </def-item>


        <def-item>
          <term id="abb8">PSY</term>
          <def>
            <p>psychosomatic medicine and psycho-oncology</p>
          </def>
        </def-item>

        <def-item>
          <term id="abb9">PHQ-4</term>
          <def>
            <p>Patient Health Questionnaire-4</p>
          </def>
        </def-item>

        <def-item>
          <term id="abb10">SPE</term>
          <def>
            <p>subjective prognosis of work ability scale</p>
          </def>
        </def-item>

        <def-item>
          <term id="abb11">SUD</term>
          <def>
            <p>substance use disorders</p>
          </def>
        </def-item>

        <def-item>
          <term id="abb12">UTAUT</term>
          <def>
            <p>unified theory of acceptance and use of technology</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>Our study was part of a dissertation project of SH and funded by a research grant of the Illa and Werner Zarnekow Foundation for rehabilitation sciences. The funders had no role in designing the study, data collection and analysis, or preparation of this manuscript. We would like to thank all participants of the survey and the clinical directors and research assistants of the Mittelrhein-Klinik Boppard/Bad Salzig (Frank M Rudolph, MD; Ursula Wittig), Edelsteinklinik Bruchweiler (Edith Waldeck, MD; Daniel Funck), Drei-Burgen-Klinik Bad Kreuznach (Ute Dederichs-Masius, MD; Michael Wiegert), and Fachklinik Eußerthal (Thomas Korte, MD; Nikolaus Lange).</p>
    </ack>
    <fn-group>
      <fn fn-type="con">
        <p>RZ initiated the study. SH designed and conducted the study and wrote the draft of the manuscript. RZ and MB contributed to the design of this study. All authors contributed to the further writing of the manuscript and approved the final version of the manuscript.</p>
      </fn>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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