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    <front>
        <journal-meta>
            <journal-id journal-id-type="publisher-id">JMIR</journal-id>
            <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
            <journal-title>Journal of Medical Internet Research</journal-title>
            <issn pub-type="epub">1438-8871</issn>
            <publisher>
                <publisher-name>JMIR Publications Inc.</publisher-name>
                <publisher-loc>Toronto, Canada</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="publisher-id">v16i7e163</article-id>
            <article-id pub-id-type="pmid">24989982</article-id>
            <article-id pub-id-type="doi">10.2196/jmir.3458</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Original Paper</subject>
                </subj-group>
                <subj-group subj-group-type="article-type">
                    <subject>Original Paper</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>The Effectiveness of Loyalty Rewards to Promote the Use of an Internet-Based Heart Health Program</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="editor">
                    <name>
                        <surname>Eysenbach</surname>
                        <given-names>Gunther</given-names>
                    </name>
                </contrib>
            </contrib-group>
            <contrib-group>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Wielgosz</surname>
                        <given-names>Andreas</given-names>
                    </name>
                </contrib>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Mitchell</surname>
                        <given-names>Marc</given-names>
                    </name>
                </contrib>
            </contrib-group>
            <contrib-group>
                <contrib contrib-type="author" id="contrib1">
                    <name name-style="western">
                        <surname>Liu</surname>
                        <given-names>Sam</given-names>
                    </name>
                    <degrees>MSc</degrees>
                    <xref rid="aff1" ref-type="aff">1</xref>
                    <xref rid="aff2" ref-type="aff">2</xref>
                </contrib>
                <contrib contrib-type="author" id="contrib2">
                    <name name-style="western">
                        <surname>Hodgson</surname>
                        <given-names>Corinne</given-names>
                    </name>
                    <degrees>MSc</degrees>
                    <xref rid="aff3" ref-type="aff">3</xref>
                </contrib>
                <contrib contrib-type="author" id="contrib3">
                    <name name-style="western">
                        <surname>Zbib</surname>
                        <given-names>Ahmad M</given-names>
                    </name>
                    <degrees>MD</degrees>
                    <xref rid="aff4" ref-type="aff">4</xref>
                </contrib>
                <contrib contrib-type="author" id="contrib4">
                    <name name-style="western">
                        <surname>Payne</surname>
                        <given-names>Ada YM</given-names>
                    </name>
                    <degrees>PhD</degrees>
                    <xref rid="aff1" ref-type="aff">1</xref>
                </contrib>
                <contrib contrib-type="author" id="contrib5" corresp="yes">
                    <name name-style="western">
                        <surname>Nolan</surname>
                        <given-names>Robert P</given-names>
                    </name>
                    <degrees>PhD</degrees>
                    <xref rid="aff1" ref-type="aff">1</xref>
                    <address>
                        <institution>Cardiac eHealth Research Unit</institution>
                        <institution>Peter Munk Cardiac Center</institution>
                        <institution>University Health Network</institution>
                        <addr-line>Room 6N-618 NU</addr-line>
                        <addr-line>585 University Avenue</addr-line>
                        <addr-line>Toronto, ON, M5G 2C4</addr-line>
                        <country>Canada</country>
                        <phone>1 416 340 4800 ext 6400</phone>
                        <fax>1 416 340 3162</fax>
                        <email>rnolan@uhnres.utoronto.ca</email>
                    </address>
                    <xref rid="aff2" ref-type="aff">2</xref>
                </contrib>
            </contrib-group>
            <aff id="aff1">
                <sup>1</sup>
                <institution>Cardiac eHealth Research Unit</institution>
                <institution>Peter Munk Cardiac Center</institution>
                <institution>University Health Network</institution>
                <addr-line>Toronto, ON</addr-line>
                <country>Canada</country>
            </aff>
            <aff id="aff2">
                <sup>2</sup>
                <institution>Institute of Medical Science</institution>
                <institution>Faculty of Medicine</institution>
                <institution>University of Toronto</institution>
                <addr-line>Toronto, ON</addr-line>
                <country>Canada</country>
            </aff>
            <aff id="aff3">
                <sup>3</sup>
                <institution>Corinne S Hodgson &#38; Associates</institution>
                <addr-line>Burlington, ON</addr-line>
                <country>Canada</country>
            </aff>
            <aff id="aff4">
                <sup>4</sup>
                <institution>Digital Health and Innovation</institution>
                <institution>Heart and Stroke Foundation of Canada</institution>
                <addr-line>Toronto, ON</addr-line>
                <country>Canada</country>
            </aff>
            <author-notes>
                <corresp>Corresponding Author: Robert P Nolan <email>rnolan@uhnres.utoronto.ca</email>
                </corresp>
            </author-notes>
            <pub-date pub-type="collection">
                <month>07</month>
                <year>2014</year>
            </pub-date>
            <pub-date pub-type="epub">
                <day>02</day>
                <month>07</month>
                <year>2014</year>
            </pub-date>
            <volume>16</volume>
            <issue>7</issue>
            <elocation-id>e163</elocation-id>
            <!--history from ojs - api-xml-->
            <history>
                <date date-type="received">
                    <day>07</day>
                    <month>04</month>
                    <year>2014</year>
                </date>
                <date date-type="rev-request">
                    <day>28</day>
                    <month>04</month>
                    <year>2014</year>
                </date>
                <date date-type="rev-recd">
                    <day>10</day>
                    <month>05</month>
                    <year>2014</year>
                </date>
                <date date-type="accepted">
                    <day>12</day>
                    <month>06</month>
                    <year>2014</year>
                </date>
            </history>
            <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
            <copyright-statement>&#169;Sam Liu, Corinne Hodgson, Ahmad M Zbib, Ada YM Payne, Robert P Nolan. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 02.07.2014. </copyright-statement>
            <copyright-year>2014</copyright-year>
            <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/">
                <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.</p>
            </license>
            <self-uri xlink:href="http://www.jmir.org/2014/7/e163/" xlink:type="simple" />
            <related-article related-article-type="editorial" vol="16" page="e179" xlink:href="http://www.jmir.org/2014/7/e179/" xlink:type="simple" />
            <abstract>
                <sec sec-type="background">
                    <title>Background</title>
                    <p>Internet-based health programs have been shown to be effective in reducing risk for cardiovascular disease. However, their rates of enrollment and engagement remain low. It is currently unclear whether rewards from established loyalty programs can serve as a conditioned stimulus to improve the use of a freely available Internet-based program.</p>
                </sec>
                <sec sec-type="objective">
                    <title>Objective</title>
                    <p>The objectives of the study were to (1) examine enrollment rates and levels of engagement with the My Health eSupport program between a Conditioned Reward group and a Control group, and (2) investigate the influence of loyalty rewards and participant characteristics on levels of enrollment and program engagement.</p>
                </sec>
                <sec sec-type="methods">
                    <title>Methods</title>
                    <p>The study sample (n=142,726) consisted of individuals who were offered enrollment in an Internet-based health intervention (My Health eSupport) after completing the Heart&#38;Stroke Risk Assessment on the Heart and Stroke Foundation website. My Health eSupport programs provided encouragement and tips for lifestyle change. This is a free, self-guided, fully automated program that proactively delivers tailored email messages at 2-week intervals based on the participant&#8217;s stage of motivational &#8220;readiness&#8221; and priority for lifestyle change. Participants in the Conditioned Reward group were offered a single exposure of 20 loyalty reward points from the Air Miles loyalty program for completing the Heart&#38;Stroke Risk Assessment (10 reward points) and enrolling in the Internet-based program (10 reward points). Meanwhile, no rewards were given to the Control group participants. All data were collected between February 1, 2011 and February 10, 2012.</p>
                </sec>
                <sec sec-type="results">
                    <title>Results</title>
                    <p>In total, 51.38% (73,327/142,726) of individuals in the Conditioned Reward group and 48.62% (69,399/142,726) of individuals in the Control group completed the Heart&#38;Stroke Risk Assessment. Subsequently, significantly more individuals from the Conditioned Reward group (52.96%, 38,835/73,327) enrolled in the My Health eSupport program than Controls (4.07%, 2826/69,399). Regression analyses indicated that individuals were 27.9 times (95% CI 26.4-29.4; <italic>P</italic>&#60;.001) more likely to join the My Health eSupport program when presented with loyalty rewards controlling for gender, age, education, ethnicity, employment, and number of modifiable risk factors. However, ongoing engagement level was low in both groups and it was not influenced by loyalty rewards. Instead, individuals were more likely to engage with the My Health eSupport program if they were greater than 60 years of age (OR 12.56, 95% CI 5.66-27.8; <italic>P</italic>&#60;.001), were female (OR 1.27, 95% CI 1.09-1.46; <italic>P</italic>=.002), or had one or more modifiable risk factors (OR 1.38, 95% CI 1.31-1.45; <italic>P</italic>&#60;.001).</p>
                </sec>
                <sec sec-type="conclusions">
                    <title>Conclusions</title>
                    <p>Our findings suggest that a single exposure of loyalty rewards may be used to encourage individuals to enroll in an Internet-based preventative health program, but additional strategies are required to maintain engagement level. Future studies need to examine the schedules of loyalty reward reinforcement on the long-term engagement level of Internet-based health programs.</p>
                </sec>
            </abstract>
            <kwd-group>
                <kwd>Internet</kwd>
                <kwd>cardiovascular risk</kwd>
                <kwd>prevention</kwd>
                <kwd>rewards</kwd>
            </kwd-group>
        </article-meta>
    </front>
    <body>
        <sec sec-type="introduction">
            <title>Introduction</title>
            <p>Cardiovascular diseases (CVDs) are the number one cause of death globally. It is estimated that the number of people who die from CVDs will reach 23.3 million by 2030 [<xref ref-type="bibr" rid="ref1">1</xref>]. Studies have shown that more than 80% of CVDs can be prevented through lifestyle changes, such as regular exercise and a healthy diet [<xref ref-type="bibr" rid="ref2">2</xref>].</p>
            <p>The wide adoption of Internet usage presents an incredible opportunity for delivering preventive health initiatives at a population level. In 2012, approximately 83% of Canadians had personal access to the Internet: 85% of whom live in metropolitan areas and 75% in rural areas [<xref ref-type="bibr" rid="ref3">3</xref>]. This includes 63-78% of Canadians who are in the lowest income quartiles and 84% of Canadians between 45 and 64 years, which is an age group with increased risk for CVD. Several randomized controlled trials and meta-analyses have shown that Internet-based lifestyle interventions can help individuals improve self-care behaviors (physical activity, dietary habits) [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>], psychological functioning (anxiety, quality of life) [<xref ref-type="bibr" rid="ref6">6</xref>], and clinical outcomes (blood pressure, weight, blood glucose) [<xref ref-type="bibr" rid="ref7">7</xref>-<xref ref-type="bibr" rid="ref9">9</xref>]. However, enrollment and engagement in Internet-based health interventions remain a challenge [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref12">12</xref>]. This can limit the significant impact that Internet-based interventions have on health behavior change at a population level.</p>
            <p>External rewards such as financial and loyalty rewards have been used as a strategy to increase the enrollment and engagement of behavioral interventions [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. The theoretical rationale for using these external rewards to reinforce behavior change is based on both operant learning and behavioral economic theory [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref15">15</xref>]. The key principle of operant learning is that behavior is conditioned by contingencies that are rewarding or punishing in nature [<xref ref-type="bibr" rid="ref13">13</xref>]. Economic theory includes the principles from operant theory and states that an individual tends to behave in ways that maximize one&#8217;s immediate reward [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref15">15</xref>]. According to these theories, the propensity for enrollment and sustained engagement in Internet-based programs may be enhanced by introducing external rewards. On the contrary, self-determination theory (SDT) asserts that an external reward may weaken intrinsic motivation for behavior change and this is known as the &#8220;crowding out&#8221; effect [<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>]. It is currently unclear whether a single bout of reward from a loyalty program can serve as a conditioned stimulus affecting the enrollment and engagement of a freely available Internet-based health program. An advantage of using loyalty rewards over financial ones is that it may be more sustainable as both businesses and consumers can mutually benefit. Loyalty reward programs can help businesses gain new and retain existing customers by rewarding them with loyalty &#8220;reward points&#8221;. These customers can then redeem their reward points for goods and/or services from the loyalty program. Thus, the aims of this study were to (1) examine enrollment rates and levels of engagement with the My Health eSupport program between the Conditioned Reward and the Control group, and (2) investigate the influence of loyalty rewards and participant characteristics on levels of enrollment and program engagement. A previous study reported that a single bout of financial reward (US$2.00-$20.00) could increase enrollment and response to a follow-up survey 3 months after enrollment for an Internet-based health program [<xref ref-type="bibr" rid="ref18">18</xref>]. Therefore, we hypothesized that enrollment rates and level of engagement would be higher in the Conditioned Reward group than Controls. Results were expected to be influenced by age, ethnicity, education, gender, employment status, and the number of modifiable risk factors [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref18">18</xref>].</p>
        </sec>
        <sec sec-type="methods">
            <title>Methods</title>
            <sec>
                <title>Overview</title>
                <p>This was an observational study and the data was collected by the Heart and Stroke Foundation of Canada (HSFC) between February 1, 2011 and February 10, 2012. The HSFC is a non-profit public organization that aims to empower Canadians to live healthy lives free of heart disease and stroke by raising awareness of the key risk factors and encouraging and supporting them to play an active role in managing their health. Study participants were 18 years or older and provided consent for the study. All personal identifiers were removed prior to retrieving the records from the HSFC database. This study was approved by the University Health Network Ethics Board.</p>
            </sec>
            <sec>
                <title>Recruitment and Study Protocol</title>
                <p>The study sample consisted of individuals who were invited to participate in an Internet-based heart health program (My Health eSupport) after completing their Heart&#38;Stroke Risk Assessment on the HSFC website. A total of 142,726 individuals completed the Heart&#38;Stroke Risk Assessment and were included in our analyses. This sample was comprised of two groups: Conditioned Reward vs Control. Participants in the Conditioned Reward group were recruited from the Air Miles loyalty program using a standardized recruitment email. The email described the opportunity to receive a non-cash, uniform reward of up to 20 Air Miles reward points for enrolling in the My Health eSupport HSFC program. Specifically, participants were assured of immediately receiving 10 Air Miles reward points for completing the Heart&#38;Stroke Risk Assessment and another 10 Air Miles for enrolling in My Health eSupport. No additional rewards were given after enrollment. The Heart&#38;Stroke Risk Assessment was a free e-tool on the HSFC website that first enabled individuals to assess their lifestyle in regard to CVD risk. It then offered enrollment to the My Health eSupport program. Enrollment in the My Health eSupport program required the participants to first complete the Heart&#38;Stroke Risk Assessment and create a log-in ID on the HSFC website. Air Miles participants accessed the Heart&#38;Stroke Risk Assessment and claimed the reward using a unique Web link embedded in the recruitment email. Air Miles participants who completed the Heart&#38;Stroke Risk Assessment were assigned to the Conditioned Reward group. Participants in the Control group accessed the Heart&#38;Stroke Risk Assessment on the HSFC website without using the unique Web link provided by the Air Miles loyalty program. Control participants did not receive any rewards for completing either program.</p>
            </sec>
            <sec>
                <title>Program Description</title>
                <p>The My Health eSupport program was a free, self-guided, fully automated healthy lifestyle program that proactively delivered tailored email messages at 2-week intervals. The emails contained information on heart healthy living with links to the HSFC website. The initial email from My Health eSupport was delivered to the participants following enrollment. The email guided participants to report their stage of motivational &#8220;readiness&#8221; to adhere to Health Canada guidelines for diet (daily intake of fruit, vegetables, and restriction of dietary fat and salt), exercise (planned exercise and daily activity), and smoke-free living. Readiness for change was operationally defined for each behavior according to the conventional algorithm of Prochaska&#8217;s Transtheoretical Model [<xref ref-type="bibr" rid="ref19">19</xref>] (Pre-contemplation, Contemplation, Preparation, Action, and Maintenance). In an effort to reinforce motivation and efficacy for self-directed change [<xref ref-type="bibr" rid="ref20">20</xref>], subjects were then prompted to choose their priority for lifestyle change from the above-noted behaviors associated with diet, exercise, and smoke-free living. Subsequently, three email messages tailored to the individuals&#8217; readiness and priority for lifestyle change were delivered at 2-week intervals. The assessment of readiness and priority for lifestyle change was then repeated 6 weeks later from the initial assessment.</p>
            </sec>
            <sec>
                <title>Measures</title>
                <p>This paper evaluated enrollment rates and levels of engagement in the My Health eSupport program in both the Conditioned Reward and Control groups. Enrollment rate was calculated as the number of individuals who enrolled in the My Health eSupport program divided by the number of participants who completed the Heart&#38;Stroke Risk Assessment. Two measures of engagement level with the program were calculated. The initial engagement was defined as the proportion of individuals who completed the assessment of readiness and priority for lifestyle change during the first email. Ongoing engagement was defined as completion of the assessment of readiness and priority for lifestyle the second time at 6 weeks following initial engagement. Participants completed the second assessment of readiness and priority for lifestyle change within 8 weeks from receiving the re-assessment email. Characteristics of participants were extracted from self-reported data in the Heart&#38;Stroke Risk Assessment, which is an online self-assessment questionnaire. Characteristics included age, gender, education level, ethnicity, employment, medical condition(s), and body mass index (calculated from height and weight). Modifiable CVD risk factors were defined as the following: physical activity level (whether participants achieved 30-60 minutes of moderate exercise, 4 times per week), smoking status (Yes or No), excess alcohol consumption (Male: consumed &#62;2 drinks a day or &#62;14 drinks a week; Female: consumed &#62;2 drinks a day, &#62;9 drinks a week), and whether participants consumed high fat foods (3 or more times per week), fruits and vegetable (5 or more servings per day), and food with high salt content (3 or more times per week).</p>
            </sec>
            <sec>
                <title>Data Analysis</title>
                <p>Chi-square and independent <italic>t</italic> tests were used to compare characteristic differences between the Conditioned Reward and Control groups. Statistical significance can be influenced by a large sample size [<xref ref-type="bibr" rid="ref21">21</xref>]; therefore, we calculated effect size using Cramer&#8217;s <italic>V</italic> (post chi-square statistic) and Cohen&#8217;s <italic>d</italic> (post independent <italic>t</italic> test) to determine the strength of these statistically significant results. A weak, moderate, and strong association (effect size) for Cramer&#8217;s <italic>V</italic> was defined as &#60;0.2, 0.2-0.6, and &#62;0.6, respectively [<xref ref-type="bibr" rid="ref22">22</xref>]. Meanwhile, a small, moderate, and large effect size for Cohen&#8217;s <italic>d</italic> was defined as &#8804;0.2, 0.5, and &#8805;0.8, respectively [<xref ref-type="bibr" rid="ref23">23</xref>]. Binary logistic regressions were conducted to estimate the association between loyalty rewards and enrollment (model 1), initial engagement (model 2), and ongoing engagement (model 3) of the Internet-based health program. Odds ratios were calculated to identify the effects of loyalty rewards on the likelihood of enrolling and engaging with the My Health eSupport program. Based on previous research [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref18">18</xref>], all models were adjusted for age, ethnicity, education, gender, employment status, and the number of modifiable risk factors. Data were analyzed using SPSS version 19 and significance was accepted at an alpha level of .01.</p>
            </sec>
        </sec>
        <sec sec-type="results">
            <title>Results</title>
            <sec>
                <title>Participants</title>
                <p>A total of 73,327 individuals in the Conditioned Reward group and 69,399 individuals in the Control group completed the Heart&#38;Stroke Risk Assessment. Baseline characteristics of the participants are presented in <xref ref-type="table" rid="table1">Table 1</xref>. Overall, both groups attracted a larger proportion of females than males (68.48%, 97,732/142,726 vs. 31.52%, 44,994/142,726). Most of the participants were Caucasian (83.54%, 119,239/142,726). The most common illnesses in both groups were hypertension (22.43%, 32,014/142,726) and dyslipidemia (17.86%, 25,487/142,726). More than 50% of individuals reported having a BMI higher than 25. Two of the most common lifestyle factors associated with CVD risk for both groups were physical inactivity (44.10%, 62,942/142,726) and inadequate fruit and vegetable consumption (43.32%, 61,828/142,726) (<xref ref-type="table" rid="table2">Table 2</xref>).</p>
                <table-wrap position="float" id="table1">
                    <label>Table 1</label>
                    <caption>
                        <p>Baseline participant characteristics.</p>
                    </caption>
                    <table width="800" border="0" cellpadding="7" cellspacing="0" rules="groups" frame="hsides">
                        <col width="146" />
                        <col width="128" />
                        <col width="109" />
                        <col width="99" />
                        <col width="54" />
                        <col width="51" />
                        <thead>
                            <tr valign="top">
                                <td colspan="2">Characteristics</td>
                                <td>Conditioned Rewardn=73,327 n (%)</td>
                                <td>Controln=69,399 n (%)</td>
                                <td>
                                    <italic>P</italic> value</td>
                                <td>Effect size</td>
                            </tr>
                        </thead>
                        <tbody>
                            <tr valign="top">
                                <td>Age (years), mean (SD)</td>
                                <td>
                                    <break />
                                </td>
                                <td>50.4 (14.2)</td>
                                <td>50.5 (14.4)</td>
                                <td>.54</td>
                                <td>0.003</td>
                            </tr>
                            <tr valign="top">
                                <td>Female</td>
                                <td>
                                    <break />
                                </td>
                                <td>49,778 (67.88%)</td>
                                <td>47,954 (69.11%)</td>
                                <td>&#60;.001</td>
                                <td>0.01</td>
                            </tr>
                            <tr valign="top">
                                <td>Completed university education</td>
                                <td>
                                    <break />
                                </td>
                                <td>43,783 (60.74%)</td>
                                <td>41,208 (60.53%)</td>
                                <td>.40</td>
                                <td>0.002</td>
                            </tr>
                            <tr valign="top">
                                <td colspan="4">
                                    <bold>Ethnicity</bold>
                                </td>
                                <td>&#60;.001</td>
                                <td>0.13</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Caucasian</td>
                                <td>62,658 (85.48%)</td>
                                <td>56,581 (81.62%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>South Asian</td>
                                <td>1688 (2.30%)</td>
                                <td>1911 (2.76%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Chinese</td>
                                <td>3040 (4.15%)</td>
                                <td>1236 (1.78%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Aboriginal</td>
                                <td>1038 (1.42%)</td>
                                <td>1253 (1.81%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>African/black</td>
                                <td>683 (0.93%)</td>
                                <td>1160 (1.67%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td colspan="4">
                                    <bold>Marital status</bold>
                                </td>
                                <td>&#60;.001</td>
                                <td>0.03</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Married</td>
                                <td>42,396 (57.85%)</td>
                                <td>40365 (58.18%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Widowed, divorced</td>
                                <td>10,177 (13.89%)</td>
                                <td>8423 (12.14%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Single</td>
                                <td>10,787 (14.72%)</td>
                                <td>10,397 (14.99%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td colspan="6">
                                    <bold>Employment</bold>
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Full or part-time</td>
                                <td>41,279 (56.33%)</td>
                                <td>40,345 (58.16%)</td>
                                <td>&#60;.001</td>
                                <td>0.07</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Self-employed</td>
                                <td>6675 (9.11%)</td>
                                <td>6726 (9.70%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Retired</td>
                                <td>14,644 (19.98%)</td>
                                <td>11,654 (16.80%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Stay-at-home parent</td>
                                <td>3049 (4.16%)</td>
                                <td>2350 (3.39%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td colspan="4">
                                    <bold>Type of employment</bold>
                                </td>
                                <td>&#60;.001</td>
                                <td>0.08</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Management/white collar</td>
                                <td>45,660 (63.00%)</td>
                                <td>43,364 (68.81%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Sales or services</td>
                                <td>9491 (13.09%)</td>
                                <td>6757 (10.72%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Trades</td>
                                <td>6408 (8.84%)</td>
                                <td>6082 (9.65%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td colspan="4">
                                    <bold>Body Mass Index</bold>
                                </td>
                                <td>&#60;.001</td>
                                <td>0.13</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Underweight (&#60;18.5)</td>
                                <td>1464 (2.00%)</td>
                                <td>1109 (1.60%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Normal weight (18.5-24.9)</td>
                                <td>21,942 (29.93%)</td>
                                <td>19,384 (27.94%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Overweight (25-29.9)</td>
                                <td>21,240 (28.97%)</td>
                                <td>22,356 (32.21%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Obesity (&#8805;30)</td>
                                <td>16,459 (22.45%)</td>
                                <td>20,039 (28.88%)</td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <bold>Mean number of cardiovascular co-morbidities (SD)</bold>
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>0.54 (0.93)</td>
                                <td>0.51 (0.89)</td>
                                <td>&#60;.001</td>
                                <td>0.03</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Diabetes</td>
                                <td>5298 (7.23%)</td>
                                <td>3072 (4.43%)</td>
                                <td>&#60;.001</td>
                                <td>0.06</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Dyslipidemia</td>
                                <td>13,984 (19.07%)</td>
                                <td>11,503 (16.58%)</td>
                                <td>&#60;.001</td>
                                <td>0.03</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Heart disease</td>
                                <td>2795 (3.81%)</td>
                                <td>2662 (3.84%)</td>
                                <td>.81</td>
                                <td>0.001</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Hypertension</td>
                                <td>15,520 (21.17%)</td>
                                <td>16,494 (23.77%)</td>
                                <td>&#60;.001</td>
                                <td>0.11</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Stroke</td>
                                <td>1254 (1.71%)</td>
                                <td>1327 (1.91%)</td>
                                <td>.004</td>
                                <td>0.01</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Mood disorder</td>
                                <td>11,906 (16.24%)</td>
                                <td>8857 (12.76%)</td>
                                <td>&#60;.001</td>
                                <td>0.05</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Sleep apnea</td>
                                <td>3988 (5.44%)</td>
                                <td>3065 (4.42%)</td>
                                <td>&#60;.001</td>
                                <td>0.02</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <table-wrap position="float" id="table2">
                    <label>Table 2</label>
                    <caption>
                        <p>Baseline modifiable risk factors.</p>
                    </caption>
                    <table width="671" border="0" cellpadding="7" cellspacing="0" rules="groups" frame="hsides">
                        <col width="269" />
                        <col width="118" />
                        <col width="109" />
                        <col width="52" />
                        <col width="53" />
                        <thead>
                            <tr valign="top">
                                <td>Modifiable risk factors</td>
                                <td>Conditioned Reward n=73,327 n (%)</td>
                                <td>Control n=69,399 n (%)</td>
                                <td>
                                    <italic>P</italic> value</td>
                                <td>Effect size</td>
                            </tr>
                        </thead>
                        <tbody>
                            <tr valign="top">
                                <td>Physical inactivity</td>
                                <td>30,972 (42.24%)</td>
                                <td>31,970 (46.07%)</td>
                                <td>&#60;.001</td>
                                <td>0.04</td>
                            </tr>
                            <tr valign="top">
                                <td>Smoker</td>
                                <td>5704 (8.22%)</td>
                                <td>8270 (11.30%)</td>
                                <td>&#60;.001</td>
                                <td>0.05</td>
                            </tr>
                            <tr valign="top">
                                <td>Excess alcohol</td>
                                <td>17,095 (23.31%)</td>
                                <td>16,615 (23.94%)</td>
                                <td>.005</td>
                                <td>0.01</td>
                            </tr>
                            <tr valign="top">
                                <td>Fatty foods</td>
                                <td>8537 (11.69%)</td>
                                <td>10,663 (15.42%)</td>
                                <td>&#60;.001</td>
                                <td>0.06</td>
                            </tr>
                            <tr valign="top">
                                <td>Infrequent fruit and vegetable</td>
                                <td>30,601 (41.82%)</td>
                                <td>31,227 (45.05%)</td>
                                <td>&#60;.001</td>
                                <td>0.03</td>
                            </tr>
                            <tr valign="top">
                                <td>Salt</td>
                                <td>19,738 (26.92%)</td>
                                <td>14,205 (20.47%)</td>
                                <td>&#60;.001</td>
                                <td>0.08</td>
                            </tr>
                            <tr valign="top">
                                <td>Mean number of modifiable risk factors (SD)</td>
                                <td>2.51 (1.37)</td>
                                <td>2.58 (1.37)</td>
                                <td>&#60;.001</td>
                                <td>0.05</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec>
                <title>Enrollment Rates</title>
                <p>Enrollment in the My Health eSupport program was higher in the Conditioned Reward group (52.96%, 38,835/73,327) than the Controls (4.07%, 2826/69,399). Loyalty rewards provision was the strongest predictor for enrollment in the My Health eSupport program (OR 27.9, 95% CI 26.4-29.4; <italic>P</italic>&#60;.001). Factors influencing enrollment are presented in <xref ref-type="table" rid="table3">Table 3</xref>.</p>
                <table-wrap position="float" id="table3">
                    <label>Table 3</label>
                    <caption>
                        <p>Prediction of enrollment and engagement.</p>
                    </caption>
                    <table width="1100" border="0" cellpadding="7" cellspacing="0" rules="groups" frame="hsides">
                        <col width="110" />
                        <col width="62" />
                        <col width="30" />
                        <col width="49" />
                        <col width="45" />
                        <col width="30" />
                        <col width="49" />
                        <col width="45" />
                        <col width="30" />
                        <col width="49" />
                        <col width="45" />
                        <thead>
                            <tr valign="top">
                                <td rowspan="2" colspan="2">Factors</td>
                                <td colspan="3">Enrollment</td>
                                <td colspan="3">Initial engagement</td>
                                <td colspan="3">Ongoing engagement</td>
                            </tr>
                            <tr valign="top">
                                <td>OR</td>
                                <td>(95% CI)</td>
                                <td>
                                    <italic>P</italic> value</td>
                                <td>OR</td>
                                <td>(95% CI)</td>
                                <td>
                                    <italic>P</italic> value</td>
                                <td>OR</td>
                                <td>(95% CI)</td>
                                <td>
                                    <italic>P</italic> value</td>
                            </tr>
                        </thead>
                        <tbody>
                            <tr valign="top">
                                <td colspan="2">Loyalty rewards (Conditioned Reward vs Control)</td>
                                <td>27.9</td>
                                <td>(26.4-29.4)</td>
                                <td>&#60;.001</td>
                                <td>0.79</td>
                                <td>(0.66-0.92)</td>
                                <td>.004</td>
                                <td>0.93</td>
                                <td>(0.68-1.26)</td>
                                <td>.662</td>
                            </tr>
                            <tr valign="top">
                                <td>Gender (female vs male)</td>
                                <td>
                                    <break />
                                </td>
                                <td>0.96</td>
                                <td>(0.93-0.99)</td>
                                <td>.007</td>
                                <td>1.26</td>
                                <td>(1.17-1.36)</td>
                                <td>&#60;.001</td>
                                <td>1.27</td>
                                <td>(1.09-1.46)</td>
                                <td>.002</td>
                            </tr>
                            <tr valign="top">
                                <td colspan="11">
                                    <bold>Age</bold>
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>&#8804;29 years</td>
                                <td>1.98</td>
                                <td>(1.82-2.15)</td>
                                <td>&#60;.001</td>
                                <td>1.37</td>
                                <td>(0.95-1.97)</td>
                                <td>.085</td>
                                <td>1.49</td>
                                <td>(0.62-3.55)</td>
                                <td>.371</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>30-39 years</td>
                                <td>1.69</td>
                                <td>(1.56-1.82)</td>
                                <td>&#60;.001</td>
                                <td>2.32</td>
                                <td>(1.64-3.27)</td>
                                <td>&#60;.001</td>
                                <td>1.99</td>
                                <td>(0.86-4.57)</td>
                                <td>.104</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>40-49 years</td>
                                <td>1.80</td>
                                <td>(1.66-1.94)</td>
                                <td>&#60;.001</td>
                                <td>4.41</td>
                                <td>(3.14-6.17)</td>
                                <td>&#60;.001</td>
                                <td>5.86</td>
                                <td>(2.63-13.0)</td>
                                <td>&#60;.001</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>50-59 years</td>
                                <td>1.80</td>
                                <td>(1.66-1.94)</td>
                                <td>&#60;.001</td>
                                <td>6.81</td>
                                <td>(4.87-9.49)</td>
                                <td>&#60;.001</td>
                                <td>9.45</td>
                                <td>(4.27-20.8)</td>
                                <td>&#60;.001</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>&#8805;60 years</td>
                                <td>2.12</td>
                                <td>(1.96-2.30)</td>
                                <td>&#60;.001</td>
                                <td>8.40</td>
                                <td>(6.00-11.7)</td>
                                <td>&#60;.001</td>
                                <td>12.56</td>
                                <td>(5.66-27.8)</td>
                                <td>&#60;.001</td>
                            </tr>
                            <tr valign="top">
                                <td colspan="2">Ethnicity (Caucasian vs other)</td>
                                <td>1.20</td>
                                <td>(1.15-1.25)</td>
                                <td>&#60;.001</td>
                                <td>1.13</td>
                                <td>(1.01-1.24)</td>
                                <td>.025</td>
                                <td>1.12</td>
                                <td>(0.89-1.38)</td>
                                <td>.318</td>
                            </tr>
                            <tr valign="top">
                                <td colspan="2">Total number of modifiable risk factors</td>
                                <td>0.96</td>
                                <td>(0.95-0.97)</td>
                                <td>&#60;.001</td>
                                <td>1.37</td>
                                <td>(1.33-1.40)</td>
                                <td>&#60;.001</td>
                                <td>1.38</td>
                                <td>(1.31-1.45)</td>
                                <td>&#60;.001</td>
                            </tr>
                            <tr valign="top">
                                <td colspan="2">Employment (employed vs not employed)</td>
                                <td>1.02</td>
                                <td>(0.99-1.06)</td>
                                <td>.201</td>
                                <td>0.89</td>
                                <td>(0.82-0.95)</td>
                                <td>&#60;.001</td>
                                <td>1.03</td>
                                <td>(0.88-1.20)</td>
                                <td>.676</td>
                            </tr>
                            <tr valign="top">
                                <td colspan="2">University education (completed vs not completed)</td>
                                <td>1.05</td>
                                <td>(1.01-1.08)</td>
                                <td>.004</td>
                                <td>0.86</td>
                                <td>(0.79-0.91)</td>
                                <td>&#60;.001</td>
                                <td>0.88</td>
                                <td>(0.76-1.01)</td>
                                <td>.068</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec>
                <title>Engagement Level</title>
                <p>After participants enrolled in the My Health eSupport program, only 12.43% (4829/38,835) of individuals in the Conditioned Reward group and 8.49% (240/2826) of the Controls assessed their readiness for change and selected a priority area for lifestyle change. Out of these participants, 20.98% (1013/4829) in the Conditioned Reward group and 24.17% (58/240) in the Control group completed the second assessment at week 6. In our regression analyses, loyalty rewards strategy was negatively associated with initial engagement (OR 0.79, 95% CI 0.66-0.92;
                    <italic>P</italic>=.004) and it was not a significant predictor for ongoing engagement (
                    <italic>P</italic>=.66). Meanwhile, age, gender, and numbers of modifiable risk factors were significant predictors of ongoing engagement (<xref ref-type="table" rid="table3">Table 3</xref>).</p>
            </sec>
        </sec>
        <sec sec-type="discussion">
            <title>Discussion</title>
            <sec>
                <title>Principal Findings</title>
                <p>The main finding of this study was that a single exposure of loyalty rewards significantly influenced enrollment for the My Health eSupport program. Individuals were 27.9 times more likely to enroll when presented with loyalty rewards. However, contrary to our hypothesis, ongoing engagement was not influenced by loyalty rewards. Individuals were more likely to engage with the program if they were greater than 60 years of age, female, or had one or more modifiable risk factors. These findings suggest that a single exposure of loyalty rewards may be used to encourage individuals to sign up for an Internet-based preventative health initiative, but supplemental strategies are required to maintain engagement.</p>
                <p>Our findings on the effects of loyalty rewards with online enrollment were consistent with other study findings using financial rewards [<xref ref-type="bibr" rid="ref24">24</xref>]. Alexander et al [<xref ref-type="bibr" rid="ref18">18</xref>] reported that financial incentives of $2.00, $5.00, and $10.00 offered at the point of enrollment were able to enroll 3.5%, 7.5%, and 2.7% of the participants, respectively. It is encouraging to observe that, in this study, 20 Air Miles (equivalent to about $2.00 CAD) was sufficient to enroll approximately 50% of the participants. It is important to take into consideration that the participants in the Conditioned Reward group were from the Air Miles loyalty reward program. These individuals may have perceived the value of the loyalty reward as being greater than the direct monetary value of $2.00. As a result, our findings may be limited in the ability to generalize beyond Air Miles members.</p>
                <p>Engagement level with Internet-based interventions has always been a challenge as high dropout and losses to follow-up are common. This phenomenon is described by Eysenbach as &#8220;the law of attrition&#8221; [<xref ref-type="bibr" rid="ref25">25</xref>]. It is hypothesized that the attrition curve can be a valuable marker of the underlying causes for attrition. In our study, the attrition followed an L-shaped curve, which reflected an initial rapid decline of participants, with a remaining group of steady &#8220;hardcore&#8221; users who continuously used the system over the 6-week interval of this study. This type of attrition curve may indicate that the enrolled participants may not be the appropriate user group for the HSFC website [<xref ref-type="bibr" rid="ref25">25</xref>] and/or that participants did not perceive the benefits of continued engagement with the Internet-based health intervention [<xref ref-type="bibr" rid="ref26">26</xref>]. Since the My Health eSupport program was designed to reduce CVD risk through lifestyle changes, it may not be surprising that the minority of individuals who continued to engage with the eSupport program were those with higher CVD risk, such as older individuals or individuals with one or more modifiable CVD risk factors.</p>
                <p>A single exposure of loyalty reward may have also contributed to the low level of engagement with the My Health eSupport program. Since rewards were presented at the point of enrollment, some individuals in the Conditioned Reward group may have enrolled for the sole purpose of obtaining this reward. This may explain the negative association found between loyalty rewards and initial engagement level. Charness et al [<xref ref-type="bibr" rid="ref27">27</xref>] found that financial rewards may need to be presented on a number of occurrences (for at least 5 weeks) in order to help individuals pass the &#8220;threshold&#8221; level needed to sustain an activity on their own for up to 16 weeks. The long-term effectiveness (&#62;6 months) of using financial incentives to maintain behavior change remains unclear, primarily due to the fact that the majority of studies are short term (&#60;6 months) [<xref ref-type="bibr" rid="ref17">17</xref>]. A recent meta-analysis reported several design features for financial rewards that may help increase adherence to exercise programs. These included (1) providing an assured financial incentive rather than lottery or chance-based reward, (2) offering larger incentives, and (3) incorporating incentives that are designed to be indexed (eg, $25/pound of weight loss), or escalating (eg, $10 for the first pound lost, $15 for second pound lost, etc) [<xref ref-type="bibr" rid="ref17">17</xref>]. It is important to incorporate these design features into future studies aimed at behavior change using loyalty rewards.</p>
                <p>Some researchers have cautioned against the use of any external incentives as they may have the undesired effects of inhibiting intrinsic motivation [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref28">28</xref>]. Future studies on Internet-based interventions should consider how indexed or escalated loyalty rewards could be used to sustain program engagement while maintaining or increasing intrinsic motivation associated with a health behavior change. Based on self-determination theory, intrinsic motivation is fulfilled by the psychological needs of competence (a sense of mastery), autonomy (ownership over behavior), and social relatedness (feel socially connected to others) [<xref ref-type="bibr" rid="ref29">29</xref>]. Mitchell et al suggested that extrinsic rewards may be used to fulfill these psychological needs in order to avoid harming intrinsic motivation by (1) rewarding achievements of realistic self-regulatory goals (eg, the use of self-monitoring), (2) providing choice for the types of reward and the activities chosen, and (3) offering rewards that are related to social outcomes (eg, group contingencies or charitable donations) [<xref ref-type="bibr" rid="ref17">17</xref>]. Additionally, it may be necessary to combine loyalty rewards with previously established key components of counselling in order to maintain levels of engagement in Internet-based interventions. These components include: goal setting and self-monitoring; the provision of feedback based on the patients&#8217; activity; self-efficacy enhancement; and relapse prevention [<xref ref-type="bibr" rid="ref30">30</xref>].</p>
            </sec>
            <sec>
                <title>Limitations and Strengths</title>
                <p>Several limitations of the present study should be noted. The accuracy of self-reported data is open to challenge for validity. Self-report bias such as lifestyle behaviors of exercise, diet, and smoking could have influenced the accuracy of our results. Engagement with the system was defined when participants re-assessed their readiness for change and selected another priority area for lifestyle change. It is possible that individuals maintained engagement with the program but never completed the re-assessment, which may underestimate the levels of engagement with the My Health eSupport Program. There are other variables that may be associated with levels of enrollment and engagement which were not assessed, such as income, anxiety, and depression. Finally, there may be selection bias in our study as the Conditioned Reward group consisted of participants from the Air Miles loyalty reward program. This may limit our ability to generalize our findings beyond Air Miles members. A strength of this study includes the large sample size. This is one of the first &#8220;real-world&#8221; (eg, population-based) studies that has been conducted to examine the effects of loyalty rewards on enrollment and engagement with an Internet-based intervention.</p>
            </sec>
            <sec>
                <title>Conclusions</title>
                <p>Internet-based interventions hold great potential for delivering preventive health initiatives at a population level. A single exposure of loyalty rewards can increase enrollment but additional strategies are required to maintain engagement level. This study has significant design implications for incorporating loyalty rewards as an effective enrollment strategy for future Internet-based interventions. More research is needed that explores the long-term effects of using loyalty rewards to reinforce engagement level and the associated efficacy of Internet-based health programs.</p>
            </sec>
        </sec>
    </body>
    <back>
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