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    <front>
        <journal-meta>
            <journal-id journal-id-type="publisher-id">JMIR</journal-id>
            <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
            <journal-title>Journal of Medical Internet Research</journal-title>
            <issn pub-type="epub">14388871</issn>
            <publisher>
                <publisher-name>JMIR Publications Inc.</publisher-name>
                <publisher-loc>Toronto, Canada</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="publisher-id">v15i9e196</article-id>
            <article-id pub-id-type="pmid">23999406</article-id>
            <article-id pub-id-type="doi">10.2196/jmir.2755</article-id>
            <article-categories>
                <subj-group subj-group-type="article-type">
                    <subject>Original Paper</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>A Pre-Post Study on the Appropriateness and Effectiveness of a Web- and Text Messaging-Based Intervention to Reduce Problem Drinking in Emerging Adults</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="editor">
                    <name>
                        <surname>Eysenbach</surname>
                        <given-names>Gunther</given-names>
                    </name>
                </contrib>
            </contrib-group>
            <contrib-group>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Doumas</surname>
                        <given-names>Diana</given-names>
                    </name>
                </contrib>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Naughton</surname>
                        <given-names>Felix</given-names>
                    </name>
                </contrib>
            </contrib-group>
            <contrib-group>
                <contrib contrib-type="author" id="contrib1" corresp="yes">
                    <name name-style="western">
                        <surname>Haug</surname>
                        <given-names>Severin</given-names>
                    </name>
                    <degrees>PhD</degrees>
                    <xref ref-type="aff" rid="aff1">1</xref>
                    <address>
                        <institution>Swiss Research Institute for Public Health and Addiction at Zurich University</institution>
                        <addr-line>Konradstrasse 32</addr-line>
                        <addr-line>Zurich, 8031</addr-line>
                        <country>Switzerland</country>
                        <phone>41 44 448 11 74</phone>
                        <fax>41 44 448 11 70</fax>
                        <email>severin.haug@isgf.uzh.ch</email>
                    </address>
                </contrib>
                <contrib contrib-type="author" id="contrib2">
                    <name name-style="western">
                        <surname>Schaub</surname>
                        <given-names>Michael P</given-names>
                    </name>
                    <degrees>PhD</degrees>
                    <xref ref-type="aff" rid="aff1">1</xref>
                </contrib>
                <contrib contrib-type="author" id="contrib3">
                    <name name-style="western">
                        <surname>Venzin</surname>
                        <given-names>Vigeli</given-names>
                    </name>
                    <degrees>MA</degrees>
                    <xref ref-type="aff" rid="aff2">2</xref>
                </contrib>
                <contrib contrib-type="author" id="contrib4">
                    <name name-style="western">
                        <surname>Meyer</surname>
                        <given-names>Christian</given-names>
                    </name>
                    <degrees>PhD</degrees>
                    <xref ref-type="aff" rid="aff3">3</xref>
                </contrib>
                <contrib contrib-type="author" id="contrib5">
                    <name name-style="western">
                        <surname>John</surname>
                        <given-names>Ulrich</given-names>
                    </name>
                    <degrees>PhD</degrees>
                    <xref ref-type="aff" rid="aff3">3</xref>
                </contrib>
                <contrib contrib-type="author" id="contrib6">
                    <name name-style="western">
                        <surname>Gmel</surname>
                        <given-names>Gerhard</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff4">4</xref>
                </contrib>
            </contrib-group>
            <aff id="aff1" rid="aff1">
                <sup>1</sup>
                <institution>Swiss Research Institute for Public Health and Addiction at Zurich University</institution>
                <addr-line>Zurich</addr-line>
                <country>Switzerland</country>
            </aff>
            <aff id="aff2" rid="aff2">
                <sup>2</sup>
                <institution>Cantonal Office for Secondary Education</institution>
                <addr-line>Zurich</addr-line>
                <country>Switzerland</country>
            </aff>
            <aff id="aff3" rid="aff3">
                <sup>3</sup>
                <institution>Institute of Social Medicine and Prevention</institution>
                <institution>University Medicine Greifswald</institution>
                <addr-line>Greifswald</addr-line>
                <country>Germany</country>
            </aff>
            <aff id="aff4" rid="aff4">
                <sup>4</sup>
                <institution>Addiction Switzerland</institution>
                <addr-line>Lausanne</addr-line>
                <country>Switzerland</country>
            </aff>
            <author-notes>
                <corresp>Corresponding Author: Severin Haug <email>severin.haug@isgf.uzh.ch</email>
                </corresp>
            </author-notes>
            <pub-date pub-type="collection">
                <month>09</month>
                <year>2013</year>
            </pub-date>
            <pub-date pub-type="epub">
                <day>02</day>
                <month>09</month>
                <year>2013</year>
            </pub-date>
            <volume>15</volume>
            <issue>9</issue>
            <elocation-id>e196</elocation-id>
            <!--history from ojs - api-xml-->
            <history>
                <date date-type="received">
                    <day>07</day>
                    <month>06</month>
                    <year>2013</year>
                </date>
                <date date-type="rev-request">
                    <day>12</day>
                    <month>07</month>
                    <year>2013</year>
                </date>
                <date date-type="rev-recd">
                    <day>15</day>
                    <month>07</month>
                    <year>2013</year>
                </date>
                <date date-type="accepted">
                    <day>21</day>
                    <month>07</month>
                    <year>2013</year>
                </date>
            </history>
            <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
            <copyright-statement>&#169;Severin Haug, Michael P Schaub, Vigeli Venzin, Christian Meyer, Ulrich John, Gerhard Gmel. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 02.09.2013. </copyright-statement>
            <copyright-year>2013</copyright-year>
            <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/">
                <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.</p>
            </license>
            <self-uri xlink:href="http://www.jmir.org/2013/9/e196/" xlink:type="simple" />
            <abstract>
                <sec sec-type="background">
                    <title>Background</title>
                    <p>Problem drinking, particularly risky single-occasion drinking (RSOD), also called &#8220;binge drinking&#8221;, is widespread among adolescents and young adults in most Western countries. Few studies have tested the effectiveness of interventions to reduce RSOD in young people with heterogeneous and particularly lower educational background.</p>
                </sec>
                <sec sec-type="objective">
                    <title>Objective</title>
                    <p>To test the appropriateness and initial effectiveness of a combined, individually tailored Web- and text messaging (SMS)&#8211;based intervention program to reduce problem drinking in vocational school students.</p>
                </sec>
                <sec sec-type="methods">
                    <title>Methods</title>
                    <p>The fully automated program provided: (1) online feedback about an individual&#8217;s drinking pattern compared to the drinking norms of an age- and gender-specific reference group, and (2) recurrent individualized SMS messages over a time period of 3 months. Generalized Estimating Equation (GEE) analyses were used to investigate the longitudinal courses of the following outcomes over the study period of 3 months: RSOD, alcohol-related problems, mean number of standard drinks per week, and maximum number of standard drinks on an occasion.</p>
                </sec>
                <sec sec-type="results">
                    <title>Results</title>
                    <p>The program was tested in 36 school classes at 7 vocational schools in Switzerland. Regardless of their drinking behavior, 477 vocational school students who owned a mobile phone were invited to participate in the program. Of these, 364 (76.3%) participated in the program. During the intervention period, 23 out of 364 (6.3%) persons unsubscribed from participating in the program. The GEE analyses revealed decreases in the percentage of persons with RSOD from baseline (75.5%, 210/278) to follow-up assessment (67.6%, 188/278, <italic>P</italic>&#60;.001), in the percentage of persons with alcohol-related problems (20.4%, 57/280 to 14.3%, 40/280, <italic>P</italic>=.009), and in the mean number of standard drinks per week: 13.4 (SD 15.3) to 11.3 (SD 14.0), <italic>P</italic>=.002. They also revealed a trend toward a decrease in the mean of the maximum number of drinks consumed on an occasion: 11.3 (SD 10.3) to 10.5 (SD 10.3), <italic>P</italic>=.08.</p>
                </sec>
                <sec sec-type="conclusions">
                    <title>Conclusions</title>
                    <p>The results show high acceptance and promising effectiveness of this interventional approach, which could be easily and economically implemented within school classes.</p>
                </sec>
            </abstract>
            <kwd-group>
                <kwd>alcohol intervention</kwd>
                <kwd>problem drinking</kwd>
                <kwd>young people</kwd>
                <kwd>text messaging</kwd>
                <kwd>Internet</kwd>
            </kwd-group>
        </article-meta>
    </front>
    <body>
        <sec sec-type="introduction">
            <title>Introduction</title>
            <p>Alcohol use is a major cause of the disease burden in most countries of the world [<xref ref-type="bibr" rid="ref1">1</xref>]. In Europe, alcohol is responsible for 12% of male and 2% of female premature death and disability [<xref ref-type="bibr" rid="ref2">2</xref>]. Problem drinking is associated with multiple social and interpersonal problems [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>]. Indicators of problem drinking are: (1) a daily average consumption of 30 g or more of pure alcohol for men and 20 g or more for women [<xref ref-type="bibr" rid="ref4">4</xref>], and (2) risky single-occasion drinking (RSOD) (also called &#8220;binge drinking&#8221;), defined as drinking 5 or more drinks on one occasion for men and 4 or more drinks for women [<xref ref-type="bibr" rid="ref5">5</xref>]. The prevalence rates of RSOD are particularly high in adolescence and young adulthood and are higher among men than among women [<xref ref-type="bibr" rid="ref6">6</xref>].</p>
            <p>Studies testing the efficacy of interventions to reduce problem drinking in young people have been conducted predominantly in the United States and have been targeted toward college or university students [<xref ref-type="bibr" rid="ref7">7</xref>]. Within this target group, individual interventions using motivational interviewing [<xref ref-type="bibr" rid="ref8">8</xref>] or personalized normative feedback, based on the social norms approach [<xref ref-type="bibr" rid="ref9">9</xref>], showed promising findings and resulted in lower alcohol consumption and fewer alcohol-related problems [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref11">11</xref>].</p>
            <p>Social norm interventions provide information about the actual drinking norm in a reference group. They typically include an individualized drinking profile with the quantity of alcohol consumed in relation to peers, the money spent on alcohol, the calorie intake, and the individual risk patterns of alcohol-related negative consequences. In university and college students, normative feedback interventions delivered using the Web or computer, reduced drinking quantity, drinking frequency, and binge drinking in the short- and medium-term [<xref ref-type="bibr" rid="ref12">12</xref>].</p>
            <p>Computer-tailored interventions based on the social norms approach are also promising for the reduction of problem drinking in populations with lower educational backgrounds. However, it should be noted that the efficacy of tailored messages depends on the individual&#8217;s ability and motivation to process information. The Elaboration Likelihood Model [<xref ref-type="bibr" rid="ref13">13</xref>] posits that the degree to which individuals are motivated and able to process a persuasive message (Need for Cognition or NFC) determines the care with which the central merits of a message will be considered and evaluated. Individuals with low NFC pay more attention to the source of the arguments (eg, celebrities, credible authorities, experts), the ease with which they can be processed (eg, presented pictorially versus verbally), and the number of arguments presented, to process information. Although NFC is thought to reflect a cognitive motivation rather than an intellectual ability, it is positively correlated with educational level [<xref ref-type="bibr" rid="ref14">14</xref>]. Considering individuals&#8217; NFCs in the context of health behavior, interventions could be crucial for improving their outcomes [<xref ref-type="bibr" rid="ref15">15</xref>-<xref ref-type="bibr" rid="ref17">17</xref>].</p>
            <p>Social norm interventions for reducing problem drinking typically consist of a single intervention session in which participants receive tailored Web or printed feedback. Due to their length of up to 7-8 pages of text and graphics, these interventions are primarily matched with persons of higher educational levels and higher NFCs. An approach that might be more effective for individuals with lower educational levels and that might also be more persuasive if persons are processing information on the peripheral route is to provide shorter, more recurrent feedback messages.</p>
            <p>Text messaging (short message service, SMS), which is available primarily via mobile phones, provides a suitable technology to deliver short and repeated feedback messages. This service allows a cost-effective instantaneous delivery of short messages directly to individuals at any time and place. In the field of alcohol prevention, SMS particularly allows the delivery of individualized messages at times when young people typically drink alcohol [<xref ref-type="bibr" rid="ref18">18</xref>]. In Switzerland, as in most other developed countries, nearly all adolescents (98%) between the ages of 12 and 19 own a mobile phone, and SMS is the most commonly used mobile phone application [<xref ref-type="bibr" rid="ref19">19</xref>].</p>
            <p>SMS is increasingly being applied for behavior change interventions, particularly in smoking cessation and diabetes self-management [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref21">21</xref>]. For alcohol treatment, 2 pilot studies based on relatively small sample sizes are available. Suffoletto et al [<xref ref-type="bibr" rid="ref22">22</xref>] reported fewer heavy drinking days and fewer drinks per drinking day in 15 young adults reporting harmful alcohol use receiving SMSs up to 3 months after emergency treatment. In a study using twice daily supportive text messages (n=26) or a thank you text message (n=28) every 2 weeks for 3 months, co-morbid depressive and alcohol-dependent patients reported lower depression scores and a trend for higher cumulative abstinence duration [<xref ref-type="bibr" rid="ref23">23</xref>].</p>
            <p>Vocational school students are typically characterized by heterogeneous educational levels, including a significant proportion with little or no educational attainment, and high prevalence rates of hazardous drinking [<xref ref-type="bibr" rid="ref24">24</xref>]. The objectives of the present study were (1) to test the appropriateness of a combined Web- and SMS-based intervention program for the reduction of problem drinking in vocational school students, and (2) to provide an initial test of its effectiveness.</p>
        </sec>
        <sec sec-type="methods">
            <title>Methods</title>
            <sec>
                <title>Setting</title>
                <p>In most European countries, vocational schools are post-secondary public schools that are analogous to American community colleges. They are part of the dual educational system that combines apprenticeships in a business context and vocational training in a school context. Vocational schools provide general education and specific skills for a particular profession.</p>
                <p>Based on data from the Swiss Federal Statistical Office, approximately half of all adolescents ages 16 to 19 currently attend vocational schools [<xref ref-type="bibr" rid="ref25">25</xref>], with the highest proportions among adolescents ages 17 (males: 63%, females: 48%) and 18 (males: 63%, females: 49%).</p>
            </sec>
            <sec>
                <title>Design and Procedure</title>
                <p>A longitudinal pre-post study design was used to test the initial effectiveness of the program. Furthermore, differences in the longitudinal courses of the main outcome criteria between program participants and nonparticipants were explored.</p>
                <p>Directors or contact teachers for addiction prevention from all 23 vocational schools in the Swiss canton of Zurich were invited to participate through some of their classes in a study testing the effectiveness of a Web- and text messaging-based program to reduce problem drinking. Of these 23 schools, 7 vocational schools with a total of 36 school classes agreed to participate in the study. All vocational school students in the participating school classes were invited by externally trained staff to participate in an online health survey during a regular school lesson reserved for health education. To decrease reporting bias, the study assistants did not provide further information about the purpose of the study before the screening assessment was completed. The screening assessments were conducted between April 2012 and September 2012. At the time of the assessment, 490 students were present in the school classes, of whom 488 (99.6%) agreed to participate. The online screening included the assessment of demographic data, alcohol consumption, weekly physical activity, smoking status, and ownership of a mobile phone.</p>
                <p>The inclusion criterion for program participation was ownership of a mobile phone. A total of 477 of the 488 participants (97.7%) from the screening assessment owned a mobile phone. Subsequently, eligible persons were informed about the aim of the program, assessments, reimbursement, and data protection. Study and program information was provided online and in paper form by the study assistants. Eligible persons were informed that they could unsubscribe from program participation at any time simply by sending an SMS expressing their request to withdraw from the program. Additionally, they were informed that program participants would take part in a draw for 10 vouchers worth &#8364;50. Eligible persons could then decide whether to participate in the program or not. After providing informed consent online, all program participants were invited to choose a username and to provide their mobile phone number. Furthermore, additional alcohol-related variables were assessed.</p>
                <p>Follow-up assessments after 3 months were conducted in the participating school classes during regular school lessons using paper-and-pencil questionnaires. All vocational school students present in the school classes at the follow-up assessments (also students who were not eligible for participation in the program and nonparticipants) were invited to fill in a questionnaire.</p>
                <p>The study protocol was approved by the local Ethics Committee of the Canton of Zurich, Switzerland. The study was executed in compliance with the Declaration of Helsinki.</p>
            </sec>
            <sec>
                <title>Intervention</title>
                <p>The fully automated program was based on a LAMPP-system (Linux system, Apache server, MySQL-database, PHP-programming language) and included an expert system that generated individually tailored online feedback and text messages. The interventional content was based on effective social norms intervention programs developed primarily for college and university students in the United States and Canada [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref27">27</xref>] that had been modified for the target group of German-speaking adolescents in Switzerland, aged 16-20 with different educational backgrounds.</p>
                <p>The program, Alk-Check, automatically generated individually tailored online feedback and SMS messages using data from a comprehensive online assessment. The online assessment tool collected demographic information and information on alcohol consumption, drinking behavior (eg, typical drinking days and times), and alcohol-related problems. Age- and gender-specific norms for alcohol consumption were derived from a previous study [<xref ref-type="bibr" rid="ref28">28</xref>] that assessed heavy drinking occasions, alcohol volume, and the maximum number of drinks on a single occasion among 973 vocational and secondary school students in the Canton of Zurich, Switzerland.</p>
                <p>After completing the online assessment, individually tailored online feedback was provided. The online feedback was tailored according to the individual values on the following 4 baseline variables: gender, age, number of standard drinks in a typical week, and frequency of RSOD occasions in the last 30 days. The feedback included graphical and textual information concerning (1) drinks per week in relation to the age and gender-specific reference group, (2) financial costs of drinking, (3) calories consumed with alcoholic drinks, and (4) number of heavy drinking occasions in relation to the age and gender-specific reference group. The online feedback could be printed and sent by mail to the participants&#8217; email accounts.</p>
                <p>On the first level, the content and number of text messages were tailored according to baseline drinking patterns. Participants were assigned to one of three risk groups (derived from [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>]), based on their baseline drinking patterns: (1) &#8220;Non-Risk&#8221;: No RSOD occasion during the last 30 days and &#60;18 (12 for females) standard drinks in a typical week, (2) &#8220;Low-Risk&#8221;: 1 or 2 RSOD occasions during the last 30 days or no RSOD occasions during the last 30 days, and &#8805;18 (12 for females) standard drinks in a typical week, and (3) &#8220;High Risk&#8221;: &#62;2 RSOD occasions during the last 30 days.</p>
                <p>On the second level, the content of the text messages was tailored according to the individual values on the following baseline variables: gender, motivation for reduced alcohol consumption, alcohol-related problems, typical drinking day and time, number of standard drinks in a typical week, and maximum number of drinks on a single occasion during the last 30 days.</p>
                <p>Participants from all risk groups received text messages for a period of 12 weeks. Participants of the non-risk group received one weekly text message providing information from the following content categories: (1) drinking and body weight/fitness, (2) resisting peer pressure, (3) pros of sensible drinking, and (4) motivation to maintain sensible drinking.</p>
                <p>Participants of the low-risk group received one weekly text message providing information from the following content categories: (1-3), (5) motivation for sensible drinking, (6) alcohol-related problems, (7) maximum number of drinks on a single occasion and related risks, (8) risks of binge drinking, and (9) importance of reducing alcohol consumption. Additionally, they received biweekly text messages sent on the individually indicated typical drinking day and time. The latter messages specifically focused on strategies to reduce alcohol consumption and to motivate them toward sensible drinking practices. Participants of the high-risk group received one weekly text message providing information from the content categories: (1-3), (5-9), and (10) local outpatient services for alcohol counseling. They also received the additional biweekly text messages sent on the individually indicated typical drinking day and time that focused on strategies to reduce alcohol consumption and to motivate them to adopt sensible drinking practices. Examples of these text messages are shown in <xref ref-type="table" rid="table1">Table 1</xref>.</p>
                <p>Before the study, a prototype of this program was tested and evaluated in 3 focus groups. Within these focus groups, vocational school adolescents aged between 16 and 20 years evaluated the program flow, the layout and content of the online assessment and feedback, and the content of the text messages. The optimizations that resulted from these focus groups were integrated in the final program version.</p>
            </sec>
            <sec>
                <title>Measures and Outcome Criteria</title>
                <p>The screening assessment included the following demographic variables: gender, age, education, and migration background. Common Swiss levels of educational attainment were assessed: (1) none, (2) secondary school, (3) extended secondary school, and (4) technical or high school. We assessed the country of birth of both parents of the vocational school students to identify a potential migration background. Based on this information, persons were assigned to one of the following categories: (1) persons with neither parent born outside Switzerland, (2) persons with one parent born outside Switzerland, and (3) persons with both parents born outside Switzerland.</p>
                <p>Tobacco smoking was assessed using the question, &#8220;Do you currently smoke cigarettes or did you smoke in the past?&#8221; with the following response options: (1) I smoke cigarettes daily, (2) I smoke cigarettes occasionally, but not daily, (3) I smoked cigarettes in the past, but I do not smoke anymore, and (4) I have never smoked cigarettes or have smoked fewer than 100 cigarettes in my life. Current daily and occasional smokers (categories 1 and 2) were considered smokers. Self-reported moderate to vigorous physical activity was measured by a question derived from the Health Behavior in School Aged Children (HBSC) study [<xref ref-type="bibr" rid="ref29">29</xref>]: &#8220;Outside school: How many hours a week do you exercise or participate in sports that make you sweat or out of breath?&#8221;.</p>
                <p>The following 3 alcohol-related variables were included in the screening assessment: (1) frequency of RSOD occasions in the last 30 days (&#8220;How often did you have 5 [4 for females] or more drinks on one occasion in the last 30 days?&#8221; with the response categories &#8220;never&#8221;, &#8220;1-2 times&#8221;, &#8220;3-4 times&#8221;, &#8220;5-6 times&#8221;, &#8220;7-8 times&#8221;, &#8220;9-10 times&#8221;, &#8220;11-12 times&#8221;, &#8220;more than 12 times&#8221;); (2) quantity of alcohol consumption, as assessed by a 7-day drinking calendar similar to the Daily Drinking Questionnaire (DDQ) [<xref ref-type="bibr" rid="ref30">30</xref>], for which participants were asked to think about a typical week in the past month and, for each day, to record the number of standard drinks they typically consumed on that day; and (3) the maximum number of drinks consumed on a single occasion in the last 30 days.</p>
                <p>In the program, we also assessed alcohol-related problems and the motivation to reduce their alcohol consumption among participants. Alcohol-related problems were assessed by a questionnaire derived from the European School Survey Project on Alcohol and Other Drugs (ESPAD) [<xref ref-type="bibr" rid="ref31">31</xref>]. The participants were asked about the number of occasions during the last 3 months when they had experienced problems related to their alcohol use. Ten problems are listed in the questionnaire, which could be grouped into 4 categories: (1) individual problems, (2) relational problems, (3) sexual problems, and (4) delinquency problems. The importance of reducing alcohol consumption was assessed by the question, &#8220;How important is it for you to modify your alcohol consumption and to drink less?&#8221; with the response categories &#8220;very important&#8221;, &#8220;rather important&#8221;, &#8220;rather unimportant&#8221;, and &#8220;very unimportant&#8221;.</p>
                <p>To obtain the number of program participants who unsubscribed from the program (program attrition), we analyzed the log files of the SMS system in which all incoming and outgoing text messages were recorded.</p>
                <p>At follow-up, we also assessed an aspect of the usage of the SMS messages by asking the participants whether they (1) read through the SMS feedback messages thoroughly, (2) took only a short look at the feedback messages, or (3) did not read the feedback messages. Using a yes/no question, we evaluated whether the times when participants received the SMS messages were appropriate. We assessed whether the number of received SMS messages was appropriate or whether the participants would have preferred less or more SMS messages. The program participants also indicated their approval of certain statements concerning different aspects of the SMS messages and the online feedback (comprehensibility, content, degree of tailoring), using the response categories &#8220;rather yes&#8221; and &#8220;rather no&#8221;.</p>
                <p>Outcome criteria for the test of effectiveness of the intervention were: (1) RSOD in the last 30 days (yes/no), (2) frequent RSOD in the last 30 days (0-2 RSOD occasions vs &#62;2 RSOD occasions), (3) number of standard drinks in a typical week, (4) maximum number of drinks on an occasion in the last 30 days, and (5) alcohol-related problems in the last 3 months (yes/no).</p>
            </sec>
            <sec>
                <title>Data Analyses</title>
                <p>To test for baseline differences between program participants and nonparticipants, chi-square tests for categorical variables and Mann-Whitney U-tests for continuous or ordinal variables were used. For the attrition analysis (program participants lost to follow-up), we also used chi-square tests for categorical variables and Mann-Whitney U-tests for continuous or ordinal variables.</p>
                <p>We used Generalized Estimating Equation (GEE) analyses to investigate the longitudinal course of the outcome criteria over the study period of 3 months. GEE is a repeated-measures regression model that takes into account the correlation of the repeated measures within a person [<xref ref-type="bibr" rid="ref32">32</xref>]. It is a powerful and versatile procedure for analyzing longitudinal data under minimal assumptions about time dependence and allowed us to use all available longitudinal data, regardless of single missing values at follow-up.</p>
                <p>We used logistic GEE models for the binary outcome variables &#8220;RSOD&#8221; and &#8220;alcohol-related problems&#8221;, as well as GEE models for the count data of the variables &#8220;number of standard drinks in a typical week&#8221; and &#8220;maximum number of drinks on a single occasion&#8221;. Each GEE-model included the examined time variable (baseline vs follow-up assessment) as a predictor and an outcome variable as dependent variable.</p>
                <p>Given the clustered nature of the data (students within school classes), we computed robust variance estimators for all GEE analyses. An alpha level of 0.05 (2-tailed) was chosen for all statistical tests in this study. All analyses were performed using the Stata software package, version 10.</p>
                <p>Beyond the statistical examination of the longitudinal course of the outcome variables for program participants, we graphically explored the longitudinal course of the outcome variables for non-program participants in contrast to program participants. Due to a lack of statistical power, we did not use statistical tests for this comparison.</p>
                <table-wrap position="float" id="table1">
                    <label>Table 1</label>
                    <caption>
                        <p>Sample text messages from different risk groups and content categories.</p>
                    </caption>
                    <table width="619" border="0" cellpadding="7" cellspacing="0" rules="groups" frame="hsides">
                        <col width="78" />
                        <col width="166" />
                        <col width="334" />
                        <thead>
                            <tr valign="top">
                                <td>Risk Group</td>
                                <td>Content Category</td>
                                <td>Text Message</td>
                            </tr>
                        </thead>
                        <tbody>
                            <tr valign="top">
                                <td>Non-Risk</td>
                                <td>Drinking and body weight/fitness</td>
                                <td>Hi Peter. Alcohol is rich in calories, slows down the body&#8217;s burning of fat and increases one&#8217;s appetite. In short: drinking alcohol regularly makes you overweight in the long term. It&#8217;s great that you don&#8217;t drink alcohol at all!</td>
                            </tr>
                            <tr valign="top">
                                <td>Non-Risk</td>
                                <td>Resisting peer pressure</td>
                                <td>Hi Sarah. You are not just a follower who drinks alcohol to fit in. Awesome! This shows strength of character and can even impress others. Only do what you think is right.</td>
                            </tr>
                            <tr valign="top">
                                <td>Non-Risk</td>
                                <td>Pros of sensible drinking</td>
                                <td>Hey. Even with a blood alcohol content of only 0.03% (eg, 1 to 2 beers), you have an increased risk of accidents. Whether by walking, riding your bike or driving your car, without alcohol in the blood you are always safer on the road. Way to go!</td>
                            </tr>
                            <tr valign="top">
                                <td>Low-Risk</td>
                                <td>Importance of reducing alcohol consumption</td>
                                <td>Hi. You would like to drink less alcohol. That&#8217;s a smart decision for you! If you consume less alcohol, you will feel better and have more energy the next day.</td>
                            </tr>
                            <tr valign="top">
                                <td>Low-Risk</td>
                                <td>Alcohol-related problems</td>
                                <td>Hello Lucy, due to consumption of alcohol, you&#8217;ve had problems with your parents. That&#8217;s not necessary! Keep in mind that you can avoid these problems by drinking less or no alcohol at all!</td>
                            </tr>
                            <tr valign="top">
                                <td>High-Risk</td>
                                <td>Maximum number of drinks on a single occasion and related risks</td>
                                <td>Hey Mike. You recently had 14 drinks on one occasion. Your blood alcohol concentration was about 0.34% that time. With that amount of alcohol in your blood you can experience unconsciousness, loss of memory, shallow breathing, a reduction of body temperature and loss of reflexes. Watch out!</td>
                            </tr>
                            <tr valign="top">
                                <td>High-Risk</td>
                                <td>Strategies to reduce alcohol consumption and to motivate for sensible drinking</td>
                                <td>Hey. It&#8217;s good for your body to have soft drinks every now and then! Non-alcoholic drinks provide your body with important minerals and are a good, thirst-quenching alternative. By drinking them you can prevent yourself from getting drunk as quickly.</td>
                            </tr>
                            <tr valign="top">
                                <td>High-Risk</td>
                                <td>Local outpatient services for alcohol counseling</td>
                                <td>Hi Robin. Are you concerned about your own alcohol intake or that of a friend? Talking to someone about it can be really helpful. The website www.alcocheck.ch can offer you support. Write an email to info@alcocheck.ch or call 043 444 77.</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
        </sec>
        <sec sec-type="results">
            <title>Results</title>
            <sec>
                <title>Study Participants</title>
                <p>Of the 477 persons who owned a mobile phone and were therefore eligible for study participation, 364 (76.3%) registered for program participation. <xref ref-type="table" rid="table2">Table 2</xref> presents the demographic, health, and alcohol-related characteristics of program participants and nonparticipants. Program participants differed from nonparticipants with respect to the baseline variables &#8220;educational attainment&#8221; and &#8220;maximum number of drinks on an occasion in the last 30 days&#8221;. Program participants had a lower level of educational attainment (<italic>U</italic>=17402.0, <italic>P</italic>&#60;.001) and had a higher maximum number of drinks on a single occasion (<italic>U</italic>=17958.5, <italic>P</italic>=.04).</p>
                <p>After 3 months, 367 of the 477 (76.9%) students who were eligible for program participation completed follow-up assessment: program participants 280/364 (76.9%); nonparticipants 87/113 (77.0%). The attrition analysis showed that persons dropping out were significantly more likely to be smokers (&#967;<sup>2</sup>=6.2, <italic>P</italic>=.01) and to have more frequent RSOD within the last month (<italic>U</italic>=17297.5, <italic>P</italic>=.02).</p>
            </sec>
            <sec>
                <title>Appropriateness of the Intervention</title>
                <sec>
                    <title>Program Attrition</title>
                    <p>During the program, which lasted for 3 months, 23 out of the 364 (6.3%) program participants unsubscribed from participating in the program.</p>
                </sec>
                <sec>
                    <title>Program Use and Evaluation</title>
                    <p>Out of the 280 program participants who could be reached for follow-up assessment, we obtained data concerning the program use and evaluation from 234 to 269 persons, depending on the respective variable. These different frequencies are due to missing data, inconsistent data, or variables that were only assessed in some persons depending on their previous answers.</p>
                    <p>Of the program participants, 254 out of 269 persons (94.4%) with valid data indicated that they regularly received the SMS messages. Of the 249 persons with valid data, 124 (49.8%) indicated that they &#8220;read the SMS messages thoroughly&#8221;; 111 persons (44.6%) reported that they &#8220;took a short look at the feedback messages&#8221;; and 14 persons (5.6%) chose the predefined response category, &#8220;I did not read the feedback messages&#8221;.</p>
                    <p>The time when participants received the SMS messages was rated as appropriate by 75.4% of the program participants (196/260). The number of received SMS messages was rated as appropriate by 57.5% (149/259); 35.5% (92/259) would have preferred fewer; and 6.9% (18/259) would have preferred more SMS messages. <xref ref-type="table" rid="table3">Table 3</xref> presents additional evaluations of the tailored online feedback and of the SMS messages by the program participants.</p>
                    <table-wrap position="float" id="table2">
                        <label>Table 2</label>
                        <caption>
                            <p>Baseline characteristics of program participants and nonparticipants; values are numbers (%), unless stated otherwise.</p>
                        </caption>
                        <table width="619" border="0" cellpadding="7" cellspacing="0" rules="groups" frame="hsides">
                            <col width="200" />
                            <col width="185" />
                            <col width="99" />
                            <col width="78" />
                            <thead>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>
                                        <break />
                                    </td>
                                    <td>Program participants (n=364)</td>
                                    <td>Non-participants (n=113)</td>
                                </tr>
                            </thead>
                            <tbody>
                                <tr valign="top">
                                    <td>Female gender</td>
                                    <td>
                                        <break />
                                    </td>
                                    <td>89 (24.5%)</td>
                                    <td>22 (19.5%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <bold>Age in years, mean (SD)</bold>
                                    </td>
                                    <td>
                                        <break />
                                    </td>
                                    <td>18.0 (2.4)</td>
                                    <td>17.8 (1.7)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>15-16 years</td>
                                    <td>73 (20.1%)</td>
                                    <td>20 (17.7%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>17-18 years</td>
                                    <td>194 (53.3%)</td>
                                    <td>64 (56.6%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>19-20 years</td>
                                    <td>72 (19.8%)</td>
                                    <td>23 (20.4%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>21 years or older</td>
                                    <td>25 (6.9%)</td>
                                    <td>6 (5.3%)</td>
                                </tr>
                                <tr valign="top">
                                    <td colspan="4">
                                        <bold>Immigration background</bold>
                                    </td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>No immigration background</td>
                                    <td>185 (50.8%)</td>
                                    <td>45 (39.8%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>One parent born outside Switzerland</td>
                                    <td>69 (19.0%)</td>
                                    <td>22 (19.5%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>Both parents born outside Switzerland</td>
                                    <td>110 (30.2%)</td>
                                    <td>46 (40.7%)</td>
                                </tr>
                                <tr valign="top">
                                    <td colspan="4">
                                        <bold>Educational attainment</bold>
                                    </td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>None</td>
                                    <td>18 (4.9%)</td>
                                    <td>3 (2.7%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>Secondary school</td>
                                    <td>300 (82.4%)</td>
                                    <td>80 (70.8%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>Extended secondary school</td>
                                    <td>39 (10.7%)</td>
                                    <td>24 (21.2%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>Technical or high school</td>
                                    <td>7 (1.9%)</td>
                                    <td>6 (5.3%)</td>
                                </tr>
                                <tr valign="top">
                                    <td colspan="4">
                                        <bold>Tobacco smoking</bold>
                                    </td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>Never smokers or recent quitters</td>
                                    <td>171 (47.0%)</td>
                                    <td>65 (57.5%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>Current daily or occasional smokers</td>
                                    <td>193 (53.0%)</td>
                                    <td>48 (42.5%)</td>
                                </tr>
                                <tr valign="top">
                                    <td colspan="2">Hours of extracurricular moderate to vigorous physical activity per week, M (SD)</td>
                                    <td>4.5 (4.6)</td>
                                    <td>4.8 (3.9)</td>
                                </tr>
                                <tr valign="top">
                                    <td colspan="4">
                                        <bold>Frequency of risky single-occasion drinking in the last 30 days</bold>
                                    </td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>Never</td>
                                    <td>85 (23.4%)</td>
                                    <td>36 (31.9%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>1-2 times</td>
                                    <td>106 (29.1%)</td>
                                    <td>29 (25.7%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>3-4 times</td>
                                    <td>71 (19.5%)</td>
                                    <td>23 (20.4%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>5-6 times</td>
                                    <td>48 (13.2%)</td>
                                    <td>5 (4.4%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>7-8 times</td>
                                    <td>20 (5.5%)</td>
                                    <td>7 (6.2%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>9-10 times</td>
                                    <td>14 (3.8%)</td>
                                    <td>5 (4.4%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>11-12 times</td>
                                    <td>6 (1.6%)</td>
                                    <td>1 (0.9%)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>More than 12 times</td>
                                    <td>14 (3.8%)</td>
                                    <td>7 (6.2%)</td>
                                </tr>
                                <tr valign="top">
                                    <td colspan="2">Number of standard drinks in a typical week, mean (SD)</td>
                                    <td>14.1 (16.1)</td>
                                    <td>11.3 (14.4)</td>
                                </tr>
                                <tr valign="top">
                                    <td colspan="2">Maximum number of drinks on an occasion in the last 30 days, mean (SD)</td>
                                    <td>11.6 (10.8)</td>
                                    <td>10.0 (11.3)</td>
                                </tr>
                                <tr valign="top">
                                    <td colspan="2">One or more alcohol-related problems in the last 3 months</td>
                                    <td>80 (22.0%)</td>
                                    <td>
                                        <break />
                                    </td>
                                </tr>
                                <tr valign="top">
                                    <td colspan="4">
                                        <bold>Importance of reducing alcohol consumption</bold>
                                    </td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>Very unimportant</td>
                                    <td>164 (45.1%)</td>
                                    <td>
                                        <break />
                                    </td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>Rather unimportant</td>
                                    <td>121 (33.2%)</td>
                                    <td>
                                        <break />
                                    </td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>Rather important</td>
                                    <td>48 (13.2%)</td>
                                    <td>
                                        <break />
                                    </td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>Very important</td>
                                    <td>31 (8.5%)</td>
                                    <td>
                                        <break />
                                    </td>
                                </tr>
                            </tbody>
                        </table>
                    </table-wrap>
                    <table-wrap position="float" id="table3">
                        <label>Table 3</label>
                        <caption>
                            <p>Evaluation of online feedback and text messages by program participants; values are numbers (%).</p>
                        </caption>
                        <table width="619" border="0" cellpadding="7" cellspacing="0" rules="groups" frame="hsides">
                            <col width="109" />
                            <col width="204" />
                            <col width="126" />
                            <col width="123" />
                            <thead>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>
                                        <break />
                                    </td>
                                    <td>Rather Yes, n (%)</td>
                                    <td>Rather No, n (%)</td>
                                </tr>
                            </thead>
                            <tbody>
                                <tr valign="top">
                                    <td colspan="4">
                                        <bold>The online feedback was&#8230;</bold>
                                    </td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>comprehensible (n=265 )</td>
                                    <td>250 (94.3)</td>
                                    <td>15 (5.7)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>interesting (n=258)</td>
                                    <td>182 (70.5)</td>
                                    <td>76 (29.5)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>individually tailored for me (n=257)</td>
                                    <td>127 (49.4)</td>
                                    <td>130 (50.6)</td>
                                </tr>
                                <tr valign="top">
                                    <td colspan="4">
                                        <bold>The text messages were&#8230;</bold>
                                    </td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>comprehensible (n=240)</td>
                                    <td>232 (96.7)</td>
                                    <td>8 (3.3)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>helpful (n=235)</td>
                                    <td>71 (30.2)</td>
                                    <td>164 (69.8)</td>
                                </tr>
                                <tr valign="top">
                                    <td>
                                        <break />
                                    </td>
                                    <td>individually tailored for me (n=234)</td>
                                    <td>79 (33.8)</td>
                                    <td>155 (66.2)</td>
                                </tr>
                            </tbody>
                        </table>
                    </table-wrap>
                </sec>
            </sec>
            <sec>
                <title>Program Effectiveness</title>
                <sec>
                    <title>Risky Single-Occasion Drinking (RSOD)</title>
                    <p>The GEE analyses revealed a statistically significant decrease in the percentage of persons with at least one RSOD occasion in the last month from the baseline assessment to the follow-up assessment (OR 0.66, 95% CI 0.53-0.83, <italic>P</italic>&#60;.001). Considering only program participants with appropriate follow-up data, the percentage of program participants with at least one RSOD occasion in the last month was 75.5% (210/278) at baseline and 67.6% (188/278) at follow-up (<xref ref-type="fig" rid="figure1">Figure 1</xref>).</p>
                    <p>The GEE analyses also revealed a statistically significant decrease in the percentage of persons with more than two RSOD occasions in the last month from the baseline assessment to the follow-up assessment (OR 0.76, 95% CI 0.61-0.94, <italic>P</italic>=.01). Considering only program participants with follow-up data, the percentage of program participants with more than two RSOD occasions in the last month was 48.2% (134/278) at baseline and 41.0% (114/278) at follow-up (<xref ref-type="fig" rid="figure2">Figure 2</xref>).</p>
                </sec>
                <sec>
                    <title>Number of Standard Drinks in a Typical Week</title>
                    <p>The GEE analyses revealed a statistically significant decrease in the number of standard drinks in a typical week from the baseline assessment to the follow-up assessment (IRR 0.83, 95% CI 0.74-0.93, <italic>P=</italic>.002). Considering only program participants with follow-up data, the mean number of standard drinks in a typical week was 13.4 (SD 15.3) at baseline and 11.3 (SD 14.0) at follow-up (<xref ref-type="fig" rid="figure3">Figure 3</xref>).</p>
                </sec>
                <sec>
                    <title>Maximum Number of Drinks on an Occasion</title>
                    <p>An effect close to reaching statistical significance was observed on the decrease in the maximum number of drinks on an occasion in the last 30 days from baseline to follow-up assessment (IRR 0.91, 95% CI 0.83-1.01, <italic>P</italic>=.08). Considering only program participants with follow-up data, the maximum number of drinks on an occasion was 11.3 (SD 10.3) at baseline and 10.5 (SD 10.3) at follow-up (<xref ref-type="fig" rid="figure4">Figure 4</xref>).</p>
                </sec>
                <sec>
                    <title>Alcohol-Related Problems</title>
                    <p>The GEE analyses revealed a statistically significant decrease in the percentage of persons with one or more alcohol-related problems in the last 3 months from the baseline assessment to the follow-up assessment (OR 0.60, 95% CI 0.41-0.88, <italic>P</italic>=.009). Considering only program participants with follow-up data, the percentage of persons with one or more alcohol-related problems in the last 3 months was 20.4% (57/280) at baseline and 14.3% (40/280) at follow-up.</p>
                    <fig id="figure1" position="float">
                        <label>Figure 1</label>
                        <caption>
                            <p>Percentage of persons with at least one RSOD occasion in the last month (program participants: n=278; nonparticipants: n=86).</p>
                        </caption>
                        <graphic xlink:href="jmir_v15i9e196_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple" />
                    </fig>
                    <fig id="figure2" position="float">
                        <label>Figure 2</label>
                        <caption>
                            <p>Percentage of persons with more than two RSOD occasions in the last month (program participants: n=278; nonparticipants: n=86).</p>
                        </caption>
                        <graphic xlink:href="jmir_v15i9e196_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple" />
                    </fig>
                    <fig id="figure3" position="float">
                        <label>Figure 3</label>
                        <caption>
                            <p>Mean number of standard drinks in a typical week (program participants: n=247; nonparticipants: n=79).</p>
                        </caption>
                        <graphic xlink:href="jmir_v15i9e196_fig3.png" alt-version="no" mimetype="image" position="float" xlink:type="simple" />
                    </fig>
                    <fig id="figure4" position="float">
                        <label>Figure 4</label>
                        <caption>
                            <p>Maximum number of drinks on an occasion (program participants: n=275; nonparticipants: n=83).</p>
                        </caption>
                        <graphic xlink:href="jmir_v15i9e196_fig4.png" alt-version="no" mimetype="image" position="float" xlink:type="simple" />
                    </fig>
                </sec>
            </sec>
        </sec>
        <sec sec-type="discussion">
            <title>Discussion</title>
            <sec>
                <title>Principal Findings</title>
                <p>The study revealed three main findings: (1) a large percentage of vocational school students could be reached by the program, (2) the acceptance of the program was good, and (3) the program may reduce problematic alcohol consumption in young people with heterogeneous and primarily lower educational levels.</p>
                <p>The data of this study and other epidemiological studies [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref33">33</xref>] showed high prevalence rates of problem drinking in vocational school students compared to population surveys of adolescents and young adults in this age group [<xref ref-type="bibr" rid="ref34">34</xref>]. Within this high-risk group, the proactive invitation for program participation in combination with the offer of a low-threshold intervention using the Internet and SMS allowed us to reach 3 out of 4 vocational school students (76%) for participation in the program Alk-Check. Taking into account that 4 out of 5 (78%) program participants indicated that a reduction of alcohol consumption was rather unimportant or unimportant for them, this high participation rate is of special relevance. It underlines the importance of proactive recruitment and the attractiveness of the applied communication media for this target group.</p>
                <p>Participation in the program was relatively independent of gender, age, and immigration background, but participation rates were higher for persons with lower school educations and for persons with higher alcohol consumption. The latter finding shows that we were able to particularly reach the main target group of the intervention, namely young people with problem drinking.</p>
                <p>The overall acceptance of the intervention was good. Nearly all program participants (94%) stayed logged in until the end of the program lasting 3 months. The SMS messages were read by almost all program participants (94%), and both the SMS messages and the online feedback were comprehensible for almost all participants (SMS: 97%, online feedback: 94%). Room for improvement was indicated in particular concerning the tailoring of the SMS messages. While nearly half of the participants (50%) rated the online feedback as individually tailored, only 34% indicated that they perceived the SMS messages as individually tailored.</p>
                <p>The results concerning the initial effectiveness of this program derived from a pre-post investigation are promising. The data revealed a statistically significant decrease in the percentage of persons with at least one RSOD occasion in the last month from baseline assessment (76%) to follow-up assessment (68%), as well as a statistically significant decrease in the percentage of persons with more than two RSOD occasions in the last month (from 48% to 41%). Furthermore, we found statistically significant decreases in the percentages of persons with alcohol-related problems and in the mean number of standard drinks per week. These positive changes could not be observed in persons not participating in the program.</p>
            </sec>
            <sec>
                <title>Limitations</title>
                <p>One limitation of this study is its lack of a control group that was derived on the basis of random assignment. Although participants were included into the study regardless of their drinking behavior, the comparison of baseline characteristics of program participants and nonparticipants indicates toward higher levels of alcohol consumption in program participants. Therefore, beyond the intervention effects, regression to the mean might have influenced the course of alcohol-related variables from baseline to follow-up. However, lack of a control group resulted in a greater proximity to prevention practices and allowed a better estimation of the participation rate in the program.</p>
            </sec>
            <sec>
                <title>Conclusions</title>
                <p>This is the first study to test a combined Web- and SMS-based intervention program for the reduction of problem drinking and one of the very few studies to test an intervention reducing problem drinking in a school sample. The results of this study show appropriateness and promising effectiveness for this intervention approach of combining singular online feedback to provide comprehensive individualized data about a person&#8217;s alcohol consumption compared to an age- and gender-specific reference group and repeated individualized SMS messages encouraging sensible drinking. The intervention could be easily and economically implemented within school classes. Based on these initial positive results, testing this interventional approach within a randomized controlled trial would be reasonable.</p>
            </sec>
        </sec>
    </body>
    <back>
        <glossary>
            <title>Abbreviations</title>
            <def-list>
                <def-item>
                    <term id="abb1">DDQ</term>
                    <def>
                        <p>Daily Drinking Questionnaire</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb2">ESPAD</term>
                    <def>
                        <p>European School Survey Project on Alcohol and Other Drugs</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb3">GEE</term>
                    <def>
                        <p>Generalized Estimating Equation</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb4">HBSC</term>
                    <def>
                        <p>Health Behavior in School Aged Children study</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb5">NFC</term>
                    <def>
                        <p>Need for Cognition</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb6">RSOD</term>
                    <def>
                        <p>risky single-occasion drinking</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb7">SMS</term>
                    <def>
                        <p>short message service</p>
                    </def>
                </def-item>
            </def-list>
        </glossary>
        <ack>
            <p>Funding for this study was provided by the Swiss Office for the Coordination of Addiction Facilities Infodrog (Grant No 4991/11/ZH Reduktion Alkoholkonsum via SMS). We would like to thank Dr Ahmet Turan Tagmat for the technical development of the program. We appreciate the work of the study assistants who collected the data. Furthermore, we would like to thank the teachers and students of the vocational schools for supporting the project.</p>
        </ack>
        <fn-group>
            <fn fn-type="con">
                <p>Single authors (SH, GG) were also involved in the development of the intervention.</p>
            </fn>
        </fn-group>
        <ref-list>
            <ref id="ref1">
                <label>1</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Lim</surname>
                            <given-names>SS</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Vos</surname>
                            <given-names>T</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Flaxman</surname>
                            <given-names>AD</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Danaei</surname>
                            <given-names>G</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Shibuya</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Adair-Rohani</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Amann</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Anderson</surname>
                            <given-names>HR</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Andrews</surname>
                            <given-names>KG</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Aryee</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Atkinson</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bacchus</surname>
                            <given-names>LJ</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bahalim</surname>
                            <given-names>AN</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Balakrishnan</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Balmes</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Barker-Collo</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Baxter</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bell</surname>
                            <given-names>ML</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Blore</surname>
                            <given-names>JD</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Blyth</surname>
                            <given-names>F</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bonner</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Borges</surname>
                            <given-names>G</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bourne</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Boussinesq</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Brauer</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Brooks</surname>
                            <given-names>P</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bruce</surname>
                            <given-names>NG</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Brunekreef</surname>
                            <given-names>B</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bryan-Hancock</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bucello</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Buchbinder</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bull</surname>
                            <given-names>F</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Burnett</surname>
                            <given-names>RT</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Byers</surname>
                            <given-names>TE</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Calabria</surname>
                            <given-names>B</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Carapetis</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Carnahan</surname>
                            <given-names>E</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Chafe</surname>
                            <given-names>Z</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Charlson</surname>
                            <given-names>F</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Chen</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Chen</surname>
                            <given-names>JS</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Cheng</surname>
                            <given-names>AT</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Child</surname>
                            <given-names>JC</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Cohen</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Colson</surname>
                            <given-names>KE</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Cowie</surname>
                            <given-names>BC</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Darby</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Darling</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Davis</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Degenhardt</surname>
                            <given-names>L</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Dentener</surname>
                            <given-names>F</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Des Jarlais</surname>
                            <given-names>DC</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Devries</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Dherani</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ding</surname>
                            <given-names>EL</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Dorsey</surname>
                            <given-names>ER</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Driscoll</surname>
                            <given-names>T</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Edmond</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ali</surname>
                            <given-names>SE</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Engell</surname>
                            <given-names>RE</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Erwin</surname>
                            <given-names>PJ</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Fahimi</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Falder</surname>
                            <given-names>G</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Farzadfar</surname>
                            <given-names>F</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ferrari</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Finucane</surname>
                            <given-names>MM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Flaxman</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Fowkes</surname>
                            <given-names>FG</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Freedman</surname>
                            <given-names>G</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Freeman</surname>
                            <given-names>MK</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Gakidou</surname>
                            <given-names>E</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ghosh</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Giovannucci</surname>
                            <given-names>E</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Gmel</surname>
                            <given-names>G</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Graham</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Grainger</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Grant</surname>
                            <given-names>B</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Gunnell</surname>
                            <given-names>D</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Gutierrez</surname>
                            <given-names>HR</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Hall</surname>
                            <given-names>W</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Hoek</surname>
                            <given-names>HW</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Hogan</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Hosgood</surname>
                            <given-names>HD</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Hoy</surname>
                            <given-names>D</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Hu</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Hubbell</surname>
                            <given-names>BJ</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Hutchings</surname>
                            <given-names>SJ</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ibeanusi</surname>
                            <given-names>SE</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Jacklyn</surname>
                            <given-names>GL</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Jasrasaria</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Jonas</surname>
                            <given-names>JB</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kan</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kanis</surname>
                            <given-names>JA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kassebaum</surname>
                            <given-names>N</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kawakami</surname>
                            <given-names>N</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Khang</surname>
                            <given-names>YH</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Khatibzadeh</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Khoo</surname>
                            <given-names>JP</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kok</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Laden</surname>
                            <given-names>F</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Lalloo</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Lan</surname>
                            <given-names>Q</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Lathlean</surname>
                            <given-names>T</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Leasher</surname>
                            <given-names>JL</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Leigh</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Li</surname>
                            <given-names>Y</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Lin</surname>
                            <given-names>JK</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Lipshultz</surname>
                            <given-names>SE</given-names>
                        </name>
                        <name name-style="western">
                            <surname>London</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Lozano</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Lu</surname>
                            <given-names>Y</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Mak</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Malekzadeh</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Mallinger</surname>
                            <given-names>L</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Marcenes</surname>
                            <given-names>W</given-names>
                        </name>
                        <name name-style="western">
                            <surname>March</surname>
                            <given-names>L</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Marks</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Martin</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>McGale</surname>
                            <given-names>P</given-names>
                        </name>
                        <name name-style="western">
                            <surname>McGrath</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Mehta</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Mensah</surname>
                            <given-names>GA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Merriman</surname>
                            <given-names>TR</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Micha</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Michaud</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Mishra</surname>
                            <given-names>V</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Mohd Hanafiah</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Mokdad</surname>
                            <given-names>AA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Morawska</surname>
                            <given-names>L</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Mozaffarian</surname>
                            <given-names>D</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Murphy</surname>
                            <given-names>T</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Naghavi</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Neal</surname>
                            <given-names>B</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Nelson</surname>
                            <given-names>PK</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Nolla</surname>
                            <given-names>JM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Norman</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Olives</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Omer</surname>
                            <given-names>SB</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Orchard</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Osborne</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ostro</surname>
                            <given-names>B</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Page</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Pandey</surname>
                            <given-names>KD</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Parry</surname>
                            <given-names>CD</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Passmore</surname>
                            <given-names>E</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Patra</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Pearce</surname>
                            <given-names>N</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Pelizzari</surname>
                            <given-names>PM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Petzold</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Phillips</surname>
                            <given-names>MR</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Pope</surname>
                            <given-names>D</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Pope</surname>
                            <given-names>CA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Powles</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Rao</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Razavi</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Rehfuess</surname>
                            <given-names>EA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Rehm</surname>
                            <given-names>JT</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ritz</surname>
                            <given-names>B</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Rivara</surname>
                            <given-names>FP</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Roberts</surname>
                            <given-names>T</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Robinson</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Rodriguez-Portales</surname>
                            <given-names>JA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Romieu</surname>
                            <given-names>I</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Room</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Rosenfeld</surname>
                            <given-names>LC</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Roy</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Rushton</surname>
                            <given-names>L</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Salomon</surname>
                            <given-names>JA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Sampson</surname>
                            <given-names>U</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Sanchez-Riera</surname>
                            <given-names>L</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Sanman</surname>
                            <given-names>E</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Sapkota</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Seedat</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Shi</surname>
                            <given-names>P</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Shield</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Shivakoti</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Singh</surname>
                            <given-names>GM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Sleet</surname>
                            <given-names>DA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Smith</surname>
                            <given-names>E</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Smith</surname>
                            <given-names>KR</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Stapelberg</surname>
                            <given-names>NJ</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Steenland</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>St&#246;ckl</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Stovner</surname>
                            <given-names>LJ</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Straif</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Straney</surname>
                            <given-names>L</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Thurston</surname>
                            <given-names>GD</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Tran</surname>
                            <given-names>JH</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Van Dingenen</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>van Donkelaar</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Veerman</surname>
                            <given-names>JL</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Vijayakumar</surname>
                            <given-names>L</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Weintraub</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Weissman</surname>
                            <given-names>MM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>White</surname>
                            <given-names>RA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Whiteford</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Wiersma</surname>
                            <given-names>ST</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Wilkinson</surname>
                            <given-names>JD</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Williams</surname>
                            <given-names>HC</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Williams</surname>
                            <given-names>W</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Wilson</surname>
                            <given-names>N</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Woolf</surname>
                            <given-names>AD</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Yip</surname>
                            <given-names>P</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Zielinski</surname>
                            <given-names>JM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Lopez</surname>
                            <given-names>AD</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Murray</surname>
                            <given-names>CJ</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ezzati</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>AlMazroa</surname>
                            <given-names>MA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Memish</surname>
                            <given-names>ZA</given-names>
                        </name>
                    </person-group>
                    <article-title>A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010</article-title>
                    <source>Lancet</source>
                    <year>2012</year>
                    <month>12</month>
                    <day>15</day>
                    <volume>380</volume>
                    <issue>9859</issue>
                    <fpage>2224</fpage>
                    <lpage>60</lpage>
                    <pub-id pub-id-type="doi">10.1016/S0140-6736(12)61766-8</pub-id>
                    <pub-id pub-id-type="medline">23245609</pub-id>
                    <pub-id pub-id-type="pii">S0140-6736(12)61766-8</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref2">
                <label>2</label>
                <nlm-citation citation-type="book">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Anderson</surname>
                            <given-names>P</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Baumberg</surname>
                            <given-names>B</given-names>
                        </name>
                    </person-group>
                    <source>Alcohol in Europe. A Public Health Perspective. A Report for the European Commission</source>
                    <year>2006</year>
                    <publisher-loc>London</publisher-loc>
                    <publisher-name>Institute for Alcohol Studies</publisher-name>
                </nlm-citation>
            </ref>
            <ref id="ref3">
                <label>3</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Hingson</surname>
                            <given-names>RW</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Edwards</surname>
                            <given-names>EM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Heeren</surname>
                            <given-names>T</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Rosenbloom</surname>
                            <given-names>D</given-names>
                        </name>
                    </person-group>
                    <article-title>Age of drinking onset and injuries, motor vehicle crashes, and physical fights after drinking and when not drinking</article-title>
                    <source>Alcohol Clin Exp Res</source>
                    <year>2009</year>
                    <month>05</month>
                    <volume>33</volume>
                    <issue>5</issue>
                    <fpage>783</fpage>
                    <lpage>90</lpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/19298330" />
                    </comment>
                    <pub-id pub-id-type="doi">10.1111/j.1530-0277.2009.00896.x</pub-id>
                    <pub-id pub-id-type="medline">19298330</pub-id>
                    <pub-id pub-id-type="pii">ACER896</pub-id>
                    <pub-id pub-id-type="pmcid">PMC3383090</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref4">
                <label>4</label>
                <nlm-citation citation-type="book">
                    <person-group person-group-type="author">
                        <collab>British Medical Association (BMA)</collab>
                    </person-group>
                    <source>Alcohol: Guidelines on sensible drinking</source>
                    <year>1995</year>
                    <publisher-loc>London, UK</publisher-loc>
                    <publisher-name>British Medical Association</publisher-name>
                </nlm-citation>
            </ref>
            <ref id="ref5">
                <label>5</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Gmel</surname>
                            <given-names>G</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kuntsche</surname>
                            <given-names>E</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Rehm</surname>
                            <given-names>J</given-names>
                        </name>
                    </person-group>
                    <article-title>Risky single-occasion drinking: bingeing is not bingeing</article-title>
                    <source>Addiction</source>
                    <year>2011</year>
                    <month>06</month>
                    <volume>106</volume>
                    <issue>6</issue>
                    <fpage>1037</fpage>
                    <lpage>45</lpage>
                    <pub-id pub-id-type="doi">10.1111/j.1360-0443.2010.03167.x</pub-id>
                    <pub-id pub-id-type="medline">21564366</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref6">
                <label>6</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Kuntsche</surname>
                            <given-names>E</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Rehm</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Gmel</surname>
                            <given-names>G</given-names>
                        </name>
                    </person-group>
                    <article-title>Characteristics of binge drinkers in Europe</article-title>
                    <source>Soc Sci Med</source>
                    <year>2004</year>
                    <month>07</month>
                    <volume>59</volume>
                    <issue>1</issue>
                    <fpage>113</fpage>
                    <lpage>27</lpage>
                    <pub-id pub-id-type="doi">10.1016/j.socscimed.2003.10.009</pub-id>
                    <pub-id pub-id-type="medline">15087148</pub-id>
                    <pub-id pub-id-type="pii">S0277953603005458</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref7">
                <label>7</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Bewick</surname>
                            <given-names>BM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Trusler</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Barkham</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Hill</surname>
                            <given-names>AJ</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Cahill</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Mulhern</surname>
                            <given-names>B</given-names>
                        </name>
                    </person-group>
                    <article-title>The effectiveness of web-based interventions designed to decrease alcohol consumption--a systematic review</article-title>
                    <source>Prev Med</source>
                    <year>2008</year>
                    <month>07</month>
                    <volume>47</volume>
                    <issue>1</issue>
                    <fpage>17</fpage>
                    <lpage>26</lpage>
                    <pub-id pub-id-type="doi">10.1016/j.ypmed.2008.01.005</pub-id>
                    <pub-id pub-id-type="medline">18302970</pub-id>
                    <pub-id pub-id-type="pii">S0091-7435(08)00043-1</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref8">
                <label>8</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Miller</surname>
                            <given-names>JH</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Moyers</surname>
                            <given-names>T</given-names>
                        </name>
                    </person-group>
                    <article-title>Motivational interviewing in substance abuse: applications for occupational medicine</article-title>
                    <source>Occup Med</source>
                    <year>2002</year>
                    <volume>17</volume>
                    <issue>1</issue>
                    <fpage>51</fpage>
                    <lpage>65, iv</lpage>
                    <pub-id pub-id-type="medline">11726336</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref9">
                <label>9</label>
                <nlm-citation citation-type="book">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Perkins</surname>
                            <given-names>HW</given-names>
                        </name>
                    </person-group>
                    <source>The Social Norms Approach to Preventing School and College Age Substance Abuse: A Handbook for Educators, Counselors, and Clinicians. First ed</source>
                    <year>2003</year>
                    <publisher-loc>San Francisco</publisher-loc>
                    <publisher-name>Jossey-Bass</publisher-name>
                </nlm-citation>
            </ref>
            <ref id="ref10">
                <label>10</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Carey</surname>
                            <given-names>KB</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Scott-Sheldon</surname>
                            <given-names>LA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Carey</surname>
                            <given-names>MP</given-names>
                        </name>
                        <name name-style="western">
                            <surname>DeMartini</surname>
                            <given-names>KS</given-names>
                        </name>
                    </person-group>
                    <article-title>Individual-level interventions to reduce college student drinking: a meta-analytic review</article-title>
                    <source>Addict Behav</source>
                    <year>2007</year>
                    <month>11</month>
                    <volume>32</volume>
                    <issue>11</issue>
                    <fpage>2469</fpage>
                    <lpage>94</lpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/17590277" />
                    </comment>
                    <pub-id pub-id-type="doi">10.1016/j.addbeh.2007.05.004</pub-id>
                    <pub-id pub-id-type="medline">17590277</pub-id>
                    <pub-id pub-id-type="pii">S0306-4603(07)00145-1</pub-id>
                    <pub-id pub-id-type="pmcid">PMC2144910</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref11">
                <label>11</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Riper</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>van Straten</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Keuken</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Smit</surname>
                            <given-names>F</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Schippers</surname>
                            <given-names>G</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Cuijpers</surname>
                            <given-names>P</given-names>
                        </name>
                    </person-group>
                    <article-title>Curbing problem drinking with personalized-feedback interventions: a meta-analysis</article-title>
                    <source>Am J Prev Med</source>
                    <year>2009</year>
                    <month>03</month>
                    <volume>36</volume>
                    <issue>3</issue>
                    <fpage>247</fpage>
                    <lpage>55</lpage>
                    <pub-id pub-id-type="doi">10.1016/j.amepre.2008.10.016</pub-id>
                    <pub-id pub-id-type="medline">19215850</pub-id>
                    <pub-id pub-id-type="pii">S0749-3797(08)00968-9</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref12">
                <label>12</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Moreira</surname>
                            <given-names>MT</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Smith</surname>
                            <given-names>LA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Foxcroft</surname>
                            <given-names>D</given-names>
                        </name>
                    </person-group>
                    <article-title>Social norms interventions to reduce alcohol misuse in university or college students</article-title>
                    <source>Cochrane Database Syst Rev</source>
                    <year>2009</year>
                    <issue>3</issue>
                    <fpage>CD006748</fpage>
                    <pub-id pub-id-type="doi">10.1002/14651858.CD006748.pub2</pub-id>
                    <pub-id pub-id-type="medline">19588402</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref13">
                <label>13</label>
                <nlm-citation citation-type="book">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Petty</surname>
                            <given-names>RE</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Cacioppo</surname>
                            <given-names>JT</given-names>
                        </name>
                    </person-group>
                    <article-title>The elaboration likelihood model of persuasion</article-title>
                    <source>Berkowitz L ed, Advances in Experimental and Social Psychology</source>
                    <year>1986</year>
                    <publisher-loc>New York</publisher-loc>
                    <publisher-name>Academic Press</publisher-name>
                    <fpage>123</fpage>
                    <lpage>205</lpage>
                </nlm-citation>
            </ref>
            <ref id="ref14">
                <label>14</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Cacioppo</surname>
                            <given-names>JT</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Petty</surname>
                            <given-names>RE</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Feinstein</surname>
                            <given-names>JA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Jarvis</surname>
                            <given-names>WBG</given-names>
                        </name>
                    </person-group>
                    <article-title>Dispositional differences in cognitive motivation: The life and time of individuals varying in need for cognition</article-title>
                    <source>Psychological Bulletin</source>
                    <year>1996</year>
                    <volume>119</volume>
                    <fpage>197</fpage>
                    <lpage>253</lpage>
                </nlm-citation>
            </ref>
            <ref id="ref15">
                <label>15</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Carnaghi</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Cadinu</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Castelli</surname>
                            <given-names>L</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kiesner</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bragantini</surname>
                            <given-names>C</given-names>
                        </name>
                    </person-group>
                    <article-title>The best way to tell you to use a condom: the interplay between message format and individuals' level of need for cognition</article-title>
                    <source>AIDS Care</source>
                    <year>2007</year>
                    <month>03</month>
                    <volume>19</volume>
                    <issue>3</issue>
                    <fpage>432</fpage>
                    <lpage>40</lpage>
                    <pub-id pub-id-type="doi">10.1080/09540120600582013</pub-id>
                    <pub-id pub-id-type="medline">17453580</pub-id>
                    <pub-id pub-id-type="pii">777050803</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref16">
                <label>16</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Haug</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Meyer</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ulbricht</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Gross</surname>
                            <given-names>B</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Rumpf</surname>
                            <given-names>HJ</given-names>
                        </name>
                        <name name-style="western">
                            <surname>John</surname>
                            <given-names>U</given-names>
                        </name>
                    </person-group>
                    <article-title>Need for cognition as a predictor and a moderator of outcome in a tailored letters smoking cessation intervention</article-title>
                    <source>Health Psychol</source>
                    <year>2010</year>
                    <month>07</month>
                    <volume>29</volume>
                    <issue>4</issue>
                    <fpage>367</fpage>
                    <lpage>73</lpage>
                    <pub-id pub-id-type="doi">10.1037/a0019450</pub-id>
                    <pub-id pub-id-type="medline">20658823</pub-id>
                    <pub-id pub-id-type="pii">2010-14873-008</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref17">
                <label>17</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Vidrine</surname>
                            <given-names>JI</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Simmons</surname>
                            <given-names>VN</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Brandon</surname>
                            <given-names>TH</given-names>
                        </name>
                    </person-group>
                    <article-title>Construction of smoking-relevant risk perceptions among college students: the influence of need for cognition and message content</article-title>
                    <source>Journal of Applied Social Psychology</source>
                    <year>2007</year>
                    <volume>37</volume>
                    <fpage>91</fpage>
                    <lpage>114</lpage>
                </nlm-citation>
            </ref>
            <ref id="ref18">
                <label>18</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Kuntsche</surname>
                            <given-names>E</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Robert</surname>
                            <given-names>B</given-names>
                        </name>
                    </person-group>
                    <article-title>Short message service (SMS) technology in alcohol research--a feasibility study</article-title>
                    <source>Alcohol Alcohol</source>
                    <year>2009</year>
                    <volume>44</volume>
                    <issue>4</issue>
                    <fpage>423</fpage>
                    <lpage>8</lpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://alcalc.oxfordjournals.org/cgi/pmidlookup?view=long&#38;pmid=19482879" />
                    </comment>
                    <pub-id pub-id-type="doi">10.1093/alcalc/agp033</pub-id>
                    <pub-id pub-id-type="medline">19482879</pub-id>
                    <pub-id pub-id-type="pii">agp033</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref19">
                <label>19</label>
                <nlm-citation citation-type="book">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Willemse</surname>
                            <given-names>I</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Waller</surname>
                            <given-names>G</given-names>
                        </name>
                        <name name-style="western">
                            <surname>S&#252;ss</surname>
                            <given-names>D</given-names>
                        </name>
                    </person-group>
                    <source>JAMES: Youth, Activity, Media in Switzerland</source>
                    <year>2010</year>
                    <publisher-loc>Zürich</publisher-loc>
                    <publisher-name>Z&#252;rcher Hochschule f&#252;r angewandte Wissenschaften</publisher-name>
                </nlm-citation>
            </ref>
            <ref id="ref20">
                <label>20</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Whittaker</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>McRobbie</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bullen</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Borland</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Rodgers</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Gu</surname>
                            <given-names>Y</given-names>
                        </name>
                    </person-group>
                    <article-title>Mobile phone-based interventions for smoking cessation</article-title>
                    <source>Cochrane Database Syst Rev</source>
                    <year>2012</year>
                    <volume>11</volume>
                    <fpage>CD006611</fpage>
                    <pub-id pub-id-type="doi">10.1002/14651858.CD006611.pub3</pub-id>
                    <pub-id pub-id-type="medline">23152238</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref21">
                <label>21</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Fjeldsoe</surname>
                            <given-names>BS</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Marshall</surname>
                            <given-names>AL</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Miller</surname>
                            <given-names>YD</given-names>
                        </name>
                    </person-group>
                    <article-title>Behavior change interventions delivered by mobile telephone short-message service</article-title>
                    <source>Am J Prev Med</source>
                    <year>2009</year>
                    <month>02</month>
                    <volume>36</volume>
                    <issue>2</issue>
                    <fpage>165</fpage>
                    <lpage>73</lpage>
                    <pub-id pub-id-type="doi">10.1016/j.amepre.2008.09.040</pub-id>
                    <pub-id pub-id-type="medline">19135907</pub-id>
                    <pub-id pub-id-type="pii">S0749-3797(08)00892-1</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref22">
                <label>22</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Suffoletto</surname>
                            <given-names>B</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Callaway</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kristan</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kraemer</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Clark</surname>
                            <given-names>DB</given-names>
                        </name>
                    </person-group>
                    <article-title>Text-message-based drinking assessments and brief interventions for young adults discharged from the emergency department</article-title>
                    <source>Alcohol Clin Exp Res</source>
                    <year>2012</year>
                    <month>03</month>
                    <volume>36</volume>
                    <issue>3</issue>
                    <fpage>552</fpage>
                    <lpage>60</lpage>
                    <pub-id pub-id-type="doi">10.1111/j.1530-0277.2011.01646.x</pub-id>
                    <pub-id pub-id-type="medline">22168137</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref23">
                <label>23</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Agyapong</surname>
                            <given-names>VI</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ahern</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>McLoughlin</surname>
                            <given-names>DM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Farren</surname>
                            <given-names>CK</given-names>
                        </name>
                    </person-group>
                    <article-title>Supportive text messaging for depression and comorbid alcohol use disorder: single-blind randomised trial</article-title>
                    <source>J Affect Disord</source>
                    <year>2012</year>
                    <month>12</month>
                    <day>10</day>
                    <volume>141</volume>
                    <issue>2-3</issue>
                    <fpage>168</fpage>
                    <lpage>76</lpage>
                    <pub-id pub-id-type="doi">10.1016/j.jad.2012.02.040</pub-id>
                    <pub-id pub-id-type="medline">22464008</pub-id>
                    <pub-id pub-id-type="pii">S0165-0327(12)00189-9</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref24">
                <label>24</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Haug</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Schaub</surname>
                            <given-names>MP</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Salis Gross</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>John</surname>
                            <given-names>U</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Meyer</surname>
                            <given-names>C</given-names>
                        </name>
                    </person-group>
                    <article-title>Predictors of hazardous drinking, tobacco smoking and physical inactivity in vocational school students</article-title>
                    <source>BMC Public Health</source>
                    <year>2013</year>
                    <volume>13</volume>
                    <fpage>475</fpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.biomedcentral.com/1471-2458/13/475" />
                    </comment>
                    <pub-id pub-id-type="doi">10.1186/1471-2458-13-475</pub-id>
                    <pub-id pub-id-type="medline">23672294</pub-id>
                    <pub-id pub-id-type="pii">1471-2458-13-475</pub-id>
                    <pub-id pub-id-type="pmcid">PMC3658930</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref25">
                <label>25</label>
                <nlm-citation citation-type="web">
                    <person-group person-group-type="author">
                        <collab>Bundesamt f&#252;r Statistik</collab>
                    </person-group>
                    <source>School attendance of persons aged 16 to 26 in Switzerland</source>
                    <year>2010</year>
                    <publisher-loc>Neuchatel</publisher-loc>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.bfs.admin.ch/bfs/portal/de/index/themen/15/04/00/blank/uebersicht.html">http://www.bfs.admin.ch/bfs/portal/de/index/themen/15/04/00/blank/uebersicht.html</ext-link>
                    </comment>
                </nlm-citation>
            </ref>
            <ref id="ref26">
                <label>26</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Cunningham</surname>
                            <given-names>JA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Humphreys</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kypri</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>van Mierlo</surname>
                            <given-names>T</given-names>
                        </name>
                    </person-group>
                    <article-title>Formative evaluation and three-month follow-up of an online personalized assessment feedback intervention for problem drinkers</article-title>
                    <source>J Med Internet Res</source>
                    <year>2006</year>
                    <volume>8</volume>
                    <issue>2</issue>
                    <fpage>e5</fpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2006/2/e5/" />
                    </comment>
                    <pub-id pub-id-type="doi">10.2196/jmir.8.2.e5</pub-id>
                    <pub-id pub-id-type="medline">16867968</pub-id>
                    <pub-id pub-id-type="pii">v8i2e5</pub-id>
                    <pub-id pub-id-type="pmcid">PMC1550700</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref27">
                <label>27</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Doumas</surname>
                            <given-names>DM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>McKinley</surname>
                            <given-names>LL</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Book</surname>
                            <given-names>P</given-names>
                        </name>
                    </person-group>
                    <article-title>Evaluation of two Web-based alcohol interventions for mandated college students</article-title>
                    <source>J Subst Abuse Treat</source>
                    <year>2009</year>
                    <month>01</month>
                    <volume>36</volume>
                    <issue>1</issue>
                    <fpage>65</fpage>
                    <lpage>74</lpage>
                    <pub-id pub-id-type="doi">10.1016/j.jsat.2008.05.009</pub-id>
                    <pub-id pub-id-type="medline">18657941</pub-id>
                    <pub-id pub-id-type="pii">S0740-5472(08)00084-6</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref28">
                <label>28</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Gmel</surname>
                            <given-names>G</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Venzin</surname>
                            <given-names>V</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Marmet</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Danko</surname>
                            <given-names>G</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Labhart</surname>
                            <given-names>F</given-names>
                        </name>
                    </person-group>
                    <article-title>A quasi-randomized group trial of a brief alcohol intervention on risky single occasion drinking among secondary school students</article-title>
                    <source>Int J Public Health</source>
                    <year>2012</year>
                    <month>12</month>
                    <volume>57</volume>
                    <issue>6</issue>
                    <fpage>935</fpage>
                    <lpage>44</lpage>
                    <pub-id pub-id-type="doi">10.1007/s00038-012-0419-0</pub-id>
                    <pub-id pub-id-type="medline">23089675</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref29">
                <label>29</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Suppli</surname>
                            <given-names>CH</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Due</surname>
                            <given-names>P</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Henriksen</surname>
                            <given-names>PW</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Rayce</surname>
                            <given-names>SL</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Holstein</surname>
                            <given-names>BE</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Rasmussen</surname>
                            <given-names>M</given-names>
                        </name>
                    </person-group>
                    <article-title>Low vigorous physical activity at ages 15, 19 and 27: childhood socio-economic position modifies the tracking pattern</article-title>
                    <source>Eur J Public Health</source>
                    <year>2013</year>
                    <month>02</month>
                    <volume>23</volume>
                    <issue>1</issue>
                    <fpage>19</fpage>
                    <lpage>24</lpage>
                    <pub-id pub-id-type="doi">10.1093/eurpub/cks040</pub-id>
                    <pub-id pub-id-type="medline">22552259</pub-id>
                    <pub-id pub-id-type="pii">cks040</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref30">
                <label>30</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Collins</surname>
                            <given-names>RL</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Parks</surname>
                            <given-names>GA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Marlatt</surname>
                            <given-names>GA</given-names>
                        </name>
                    </person-group>
                    <article-title>Social determinants of alcohol consumption: the effects of social interaction and model status on the self-administration of alcohol</article-title>
                    <source>J Consult Clin Psychol</source>
                    <year>1985</year>
                    <month>04</month>
                    <volume>53</volume>
                    <issue>2</issue>
                    <fpage>189</fpage>
                    <lpage>200</lpage>
                    <pub-id pub-id-type="medline">3998247</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref31">
                <label>31</label>
                <nlm-citation citation-type="book">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Hibell</surname>
                            <given-names>B</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Guttormsson</surname>
                            <given-names>U</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ahlstr&#246;m</surname>
                            <given-names>S</given-names>
                        </name>
                    </person-group>
                    <source>The 2011 ESPAD report. Substance use among students in 36 European countries</source>
                    <year>2012</year>
                    <publisher-loc>Stockholm, Sweden</publisher-loc>
                    <publisher-name>The Swedish Council for Information on Alcohol and other Drugs (CAN)</publisher-name>
                </nlm-citation>
            </ref>
            <ref id="ref32">
                <label>32</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Zeger</surname>
                            <given-names>SL</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Liang</surname>
                            <given-names>KY</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Albert</surname>
                            <given-names>PS</given-names>
                        </name>
                    </person-group>
                    <article-title>Models for longitudinal data: a generalized estimating equation approach</article-title>
                    <source>Biometrics</source>
                    <year>1988</year>
                    <month>12</month>
                    <volume>44</volume>
                    <issue>4</issue>
                    <fpage>1049</fpage>
                    <lpage>60</lpage>
                    <pub-id pub-id-type="medline">3233245</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref33">
                <label>33</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Hanke</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ulbricht</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Freyer-Adam</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>John</surname>
                            <given-names>U</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Meyer</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Haug</surname>
                            <given-names>S</given-names>
                        </name>
                    </person-group>
                    <article-title>[Tobacco smoking and alcohol consumption among apprentices at vocational schools in West Pomerania, Germany]</article-title>
                    <source>Gesundheitswesen</source>
                    <year>2013</year>
                    <month>04</month>
                    <volume>75</volume>
                    <issue>4</issue>
                    <fpage>216</fpage>
                    <lpage>24</lpage>
                    <pub-id pub-id-type="doi">10.1055/s-0032-1311621</pub-id>
                    <pub-id pub-id-type="medline">22864848</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref34">
                <label>34</label>
                <nlm-citation citation-type="book">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Gmel</surname>
                            <given-names>G</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kuendig</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Maffli</surname>
                            <given-names>E</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Notari</surname>
                            <given-names>L</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Wicki</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Georges</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Grisel-Staub</surname>
                            <given-names>E</given-names>
                        </name>
                        <name name-style="western">
                            <surname>M&#252;ller</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Dubois-Arber</surname>
                            <given-names>F</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Gervasoni</surname>
                            <given-names>J-P</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Lucia</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Jeannin</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Uchtenhagen</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Schaub</surname>
                            <given-names>M</given-names>
                        </name>
                    </person-group>
                    <source>Addiction Monitoring Switzerland, Data 2011</source>
                    <year>2012</year>
                    <publisher-loc>Bern</publisher-loc>
                    <publisher-name>Bundesamt f&#252;r Gesundheit</publisher-name>
                </nlm-citation>
            </ref>
        </ref-list>
    </back>
</article>
