<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "http://dtd.nlm.nih.gov/publishing/2.0/journalpublishing.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="2.0">
    <front>
        <journal-meta>
            <journal-id journal-id-type="publisher-id">JMIR</journal-id>
            <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
            <journal-title>Journal of Medical Internet Research</journal-title>
            <issn pub-type="epub">1438-8871</issn>
            <publisher>
                <publisher-name>Gunther Eysenbach</publisher-name>
                <publisher-loc>JMIR Publications Inc., Toronto, Canada</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="publisher-id">v15i2e28</article-id>
            <article-id pub-id-type="pmid">23388554</article-id>
            <article-id pub-id-type="doi">10.2196/jmir.2153</article-id>
            <article-categories>
                <subj-group subj-group-type="article-type">
                    <subject>Original Paper</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Influence of Delivery Strategy on Message-Processing Mechanisms and Future Adherence to a Dutch Computer-Tailored Smoking Cessation Intervention</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="editor">
                    <name>
                        <surname>Eysenbach</surname>
                        <given-names>Gunther</given-names>
                    </name>
                </contrib>
            </contrib-group>
            <contrib-group>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Bennett</surname>
                        <given-names>Gary</given-names>
                    </name>
                </contrib>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Kleijn</surname>
                        <given-names>Miriam</given-names>
                    </name>
                </contrib>
            </contrib-group>
            <contrib-group>
                <contrib contrib-type="author" id="contrib1" corresp="yes">
                    <name name-style="western">
                        <surname>Stanczyk</surname>
                        <given-names>Nicola Esther</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff1">1</xref>
                    <address>
                        <institution>Maastricht University/CAPHRI</institution>
                        <institution>Department of Health Promotion</institution>
                        <institution>Maastricht University</institution>
                        <addr-line>P.Debyeplein 1</addr-line>
                        <addr-line>Maastricht, 6229 HA</addr-line>
                        <country>Netherlands</country>
                        <phone>31 43 388 2226</phone>
                        <fax>31 43 3671032</fax>
                        <email>nicola.stanczyk@maastrichtuniversity.nl</email>
                    </address>
                </contrib>
                <contrib contrib-type="author" id="contrib2">
                    <name name-style="western">
                        <surname>Crutzen</surname>
                        <given-names>Rik</given-names>
                    </name>
                    <degrees>PhD</degrees>
                    <xref ref-type="aff" rid="aff1">1</xref>
                </contrib>
                <contrib contrib-type="author" id="contrib3">
                    <name name-style="western">
                        <surname>Bolman</surname>
                        <given-names>Catherine</given-names>
                    </name>
                    <degrees>PhD</degrees>
                    <xref ref-type="aff" rid="aff2">2</xref>
                </contrib>
                <contrib contrib-type="author" id="contrib4">
                    <name name-style="western">
                        <surname>Muris</surname>
                        <given-names>Jean</given-names>
                    </name>
                    <degrees>PhD</degrees>
                    <xref ref-type="aff" rid="aff3">3</xref>
                </contrib>
                <contrib contrib-type="author" id="contrib5">
                    <name name-style="western">
                        <surname>de Vries</surname>
                        <given-names>Hein</given-names>
                    </name>
                    <degrees>PhD</degrees>
                    <xref ref-type="aff" rid="aff1">1</xref>
                </contrib>
            </contrib-group>
            <aff id="aff1" rid="aff1">
                <sup>1</sup>
                <institution>Maastricht University/CAPHRI</institution>
                <institution>Department of Health Promotion</institution>
                <institution>Maastricht University</institution>
                <addr-line>Maastricht</addr-line>
                <country>Netherlands</country>
            </aff>
            <aff id="aff2" rid="aff2">
                <sup>2</sup>
                <institution>Open University of the Netherlands</institution>
                <institution>Department of Psychology</institution>
                <institution>Open University of the Netherlands</institution>
                <addr-line>Heerlen</addr-line>
                <country>Netherlands</country>
            </aff>
            <aff id="aff3" rid="aff3">
                <sup>3</sup>
                <institution>Maastricht University/CAPHRI</institution>
                <institution>Department of General Practice</institution>
                <addr-line>Maastricht</addr-line>
                <country>Netherlands</country>
            </aff>
            <author-notes>
                <corresp>Corresponding Author: Nicola Esther Stanczyk <email>nicola.stanczyk@maastrichtuniversity.nl</email>
                </corresp>
            </author-notes>
            <pub-date pub-type="collection">
                <month>02</month>
                <year>2013</year>
            </pub-date>
            <pub-date pub-type="epub">
                <day>06</day>
                <month>02</month>
                <year>2013</year>
            </pub-date>
            <volume>15</volume>
            <issue>2</issue>
            <elocation-id>e28</elocation-id>
            <!--history from ojs - api-xml-->
            <history>
                <date date-type="received">
                    <day>02</day>
                    <month>05</month>
                    <year>2012</year>
                </date>
                <date date-type="rev-request">
                    <day>19</day>
                    <month>06</month>
                    <year>2012</year>
                </date>
                <date date-type="rev-recd">
                    <day>16</day>
                    <month>07</month>
                    <year>2012</year>
                </date>
                <date date-type="accepted">
                    <day>16</day>
                    <month>11</month>
                    <year>2012</year>
                </date>
            </history>
            <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
            <copyright-statement>&#169;Nicola Esther Stanczyk, Rik Crutzen, Catherine Bolman, Jean Muris, Hein de Vries. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 06.02.2013. </copyright-statement>
            <copyright-year>2013</copyright-year>
            <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/">
                <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.</p>
            </license>
            <self-uri xlink:href="http://www.jmir.org/2013/2/e28/" xlink:type="simple" />
            <abstract>
                <sec sec-type="background">
                    <title>Background</title>
                    <p>Smoking tobacco is one of the most preventable causes of illness and death. Web-based tailored smoking cessation interventions have shown to be effective. Although these interventions have the potential to reach a large number of smokers, they often face high attrition rates, especially among lower educated smokers. A possible reason for the high attrition rates in the latter group is that computer-tailored smoking cessation interventions may not be attractive enough as they are mainly text-based. Video-based messages might be more effective in attracting attention and stimulating comprehension in people with a lower educational level and could therefore reduce attrition rates.</p>
                </sec>
                <sec sec-type="objective">
                    <title>Objective</title>
                    <p>The objective of the present study was to investigate whether differences exist in message-processing mechanisms (attention, comprehension, self-reference, appreciation, processing) and future adherence (intention to visit/use the website again, recommend the website to others), according to delivery strategy (video or text based messages) and educational level, to a Dutch computer-tailored smoking cessation program.</p>
                </sec>
                <sec sec-type="methods">
                    <title>Methods</title>
                    <p>Smokers who were motivated to quit within the following 6 months and who were aged over 16 were included in the program. Participants were randomly assigned to one of two conditions (video/text CT). The sample was stratified into 2 categories: lower and higher educated participants. In total, 139 participants completed the first session of the web-based tailored intervention and were subsequently asked to fill out a questionnaire assessing message-processing mechanisms and future adherence. ANOVAs and regression analyses were conducted to investigate the differences in message-processing mechanisms and future adherence with regard to delivery strategy and education.</p>
                </sec>
                <sec sec-type="results">
                    <title>Results</title>
                    <p>No interaction effects were found between delivery strategy (video vs text) and educational level on message-processing mechanisms and future adherence. Delivery strategy had no effect on future adherence and processing mechanisms. However, in both groups results indicated that lower educated participants showed higher attention (<italic>F</italic>
                        <sub>1,138</sub>=3.97; <italic>P</italic>=.05) and processing levels (<italic>F</italic>
                        <sub>1,138</sub>=4.58; <italic>P</italic>=.04). Results revealed also that lower educated participants were more inclined to visit the computer-tailored intervention website again (<italic>F</italic>
                        <sub>1,138</sub>=4.43; <italic>P</italic>=.04).</p>
                </sec>
                <sec sec-type="conclusions">
                    <title>Conclusions</title>
                    <p>Computer-tailored programs have the potential to positively influence lower educated groups as they might be more involved in the computer-tailored intervention than higher educated smokers. Longitudinal studies with a larger sample are needed to gain more insight into the role of delivery strategy in tailored information and to investigate whether the intention to visit the intervention website again results in the ultimate goal of behavior change.</p>
                </sec>
                <sec>
                    <title>Trial Registration</title>
                    <p>Netherlands Trial Register (NTR3102).</p>
                </sec>
            </abstract>
            <kwd-group>
                <kwd>computer tailoring</kwd>
                <kwd>smoking cessation</kwd>
                <kwd>message-processing mechanisms</kwd>
                <kwd>e-loyalty</kwd>
                <kwd>future adherence</kwd>
            </kwd-group>
        </article-meta>
    </front>
    <body>
        <sec sec-type="introduction">
            <title>Introduction</title>
            <p>During the last decade, an increasing number of people used the Internet to obtain health-related information. In the field of health promotion, the Internet has become an important medium for the delivery of behavioral change interventions [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref2">2</xref>]. Health professionals have started to deliver several lifestyle behavior interventions through the web, including interventions aimed at smoking cessation [<xref ref-type="bibr" rid="ref3">3</xref>], nutrition behavior [<xref ref-type="bibr" rid="ref4">4</xref>], and physical activity [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>].</p>
            <p>A successful interactive strategy consists of computer-tailored interventions [<xref ref-type="bibr" rid="ref7">7</xref>] through which individuals receive personalized information and feedback on health behavior and motives for this behavior. Tailored health messages are based on a person&#8217;s answers to a questionnaire on individual characteristics related to health behavior. Current research has shown the superiority of tailored materials over existing standard materials [<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref9">9</xref>]. In the field of smoking cessation, recent studies have revealed computer-tailored smoking cessation interventions to be more effective than non-tailored interventions [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref10">10</xref>]. Yet, as with many eHealth interventions, smoking cessation interventions delivered via the Internet have high attrition rates, especially among people with lower education [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref12">12</xref>]. However, less educated people are often those who smoke more cigarettes [<xref ref-type="bibr" rid="ref13">13</xref>] and show higher nicotine addiction rates, less quit-attempts, and more relapses compared to people with a higher level of education [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>]. Past research in the Netherlands has shown that smoking prevalence was significantly higher among less educated people (29%) compared to people with a higher level of education (20%) [<xref ref-type="bibr" rid="ref13">13</xref>]. Smokers of lower socioeconomic status (LSES) are therefore a highly relevant target group for using these computer-tailored programs. Hence, it is important to investigate how attrition rates among lower educated groups can be reduced and how computer-tailored interventions can be optimized to attract groups of different education levels.</p>
            <p>A possible reason for the high attrition rates in computer-tailored interventions is that they rely heavily on text-based messages. Research suggests that video-based messages might be more effective in attracting attention and stimulating comprehension in people with a lower educational level [<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>]. Furthermore, video-based messages have been shown to require less mental effort and may help the person focus on the core elements of the message [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>]. It is therefore conceivable that video-based messages may be better for reaching lower educated groups and realizing behavior change. Additionally, higher educated groups may benefit more from in-depth processing and accordingly may be stimulated more by text-based messages [<xref ref-type="bibr" rid="ref20">20</xref>].</p>
            <p>Recent research examining computer tailoring identified different underlying message processing-mechanisms that play an important role in enhancing health communication [<xref ref-type="bibr" rid="ref21">21</xref>]. In tailored communication, five important message-processing mechanisms have been identified: attention, comprehension, processing, self-reference, and appreciation. Attention refers to the ability to focus on the receiving message. Due to the fact that paying less attention to a message lowers the overall effect, one purpose of tailored material is to increase the attention to the message. A recent study has shown stronger attention processes in people reading tailored material [<xref ref-type="bibr" rid="ref22">22</xref>]. Comprehension refers to the ability to understand the content of the message. Past studies have shown that the better the message was matched to personal attributes and preferences, the more the message was understood and remembered [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref24">24</xref>]. A psychological theory that has been used to explain the effects of tailoring is the Elaboration Likelihood Model (ELM). This theory states there are two processing routes, the peripheral and the central. Related to this theory, personally relevant messages are processed by the &#8220;central route&#8221; and therefore take more effort to process [<xref ref-type="bibr" rid="ref25">25</xref>]. The idea of tailoring is to increase the perceived relevance of the message in order to elicit a careful consideration of the message, which leads to a deeper impact of the received content. Indeed, a study about weight loss information indicated participants engaged in deeper processing of tailored information when compared to non-tailored information [<xref ref-type="bibr" rid="ref26">26</xref>]. Besides effortful processing, a further aim of tailoring is to stimulate self-referential thinking. Self-referential thinking refers to the ability to refer the given information to one&#8217;s own situation. For example, tailored weight loss materials have been shown to encourage participants to link the information to their own situation [<xref ref-type="bibr" rid="ref26">26</xref>]. Furthermore, it is also theorized that tailoring influences the appraisal of a message. Tailored materials may enhance the feeling of being well understood and would therefore lead to more appreciation compared to non-tailored information. To sum up, tailoring is used to increase the relevance of a health message by stimulating attention, comprehension, and the overall depth of message processing. The effects of tailoring on message-processing mechanisms might be further increased by the use of a suitable delivery strategy. However, as already indicated, these possible effects might be different for people with a lower or higher educational level.</p>
            <p>To our knowledge, no previous studies have empirically examined the effects of delivery strategies (video vs text) and their impact on message-processing mechanisms among different educational groups. The first aim of this paper was to explore whether there exist differences in message-processing mechanisms according to delivery strategy (video or text based messages) and educational level. Past research has shown that information processing in lower educated groups was less profound and more influenced by visual than textual information [<xref ref-type="bibr" rid="ref27">27</xref>]. Based on this, it was expected that tailoring would result in deeper information processing in lower educated smokers who received the video-based messages. In contrast, it was expected that the effects of tailoring would increase for higher educated smokers who received the text-based messages.</p>
            <p>Additionally, eHealth research has acknowledged the importance of user experience of the intervention website. User experience refers to what a person thinks and feels during and after being exposed to a website [<xref ref-type="bibr" rid="ref28">28</xref>]. Past research demonstrated the importance of user experiences (eg, trustworthiness, enjoyment) with regard to revisiting the website [<xref ref-type="bibr" rid="ref29">29</xref>]. A positive user experience is related to an increased website use [<xref ref-type="bibr" rid="ref28">28</xref>], resulting in future adherence [<xref ref-type="bibr" rid="ref30">30</xref>]. Future adherence can comprise two components: (1) the intention to revisit an Internet-delivered intervention, and (2) recommending an Internet-delivered intervention to others [<xref ref-type="bibr" rid="ref30">30</xref>]. Internet-delivered interventions and especially computer-tailored interventions often consist of several modules/feedback sessions. Since several sessions are often necessary to achieve behavior change in the long run [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>], it is important to know whether people would like to revisit the intervention website. People with a high intention to revisit the website intervention might be likely to follow further important parts/sessions of the intervention and could therefore benefit more from the intervention than people leaving the program after their first visit. Next, it is important to know whether people would recommend the Internet-delivered intervention to others since previous studies demonstrated that the &#8220;word of mouth&#8221; strategy is effective in order to increase the use of eHealth interventions [<xref ref-type="bibr" rid="ref33">33</xref>]. In order for web-based interventions to have an impact on public health, it is important that the intervention is also disseminated by the target population [<xref ref-type="bibr" rid="ref34">34</xref>]. Now that computer-tailored interventions have become an increasingly popular strategy in the field of smoking cessation interventions, it is important to examine whether future adherence of computer-tailored intervention websites is influenced by delivery strategy (video vs text) and whether these effects vary among different educational groups.</p>
            <p>The second aim of this study was to investigate whether there exist differences in future adherence according to delivery strategy (video or text based messages) and educational level. It was expected that future adherence would increase in lower educated smokers who received the video-based messages; whereas, we expected the same effects for higher educated smokers who received the text-based messages.</p>
            <p>In summary, the current study was designed to assess whether a different delivery strategy (video vs text) interacted with educational level on message-processing mechanisms and future adherence of a Dutch computer-tailored smoking cessation program.</p>
        </sec>
        <sec sec-type="methods">
            <title>Methods</title>
            <sec>
                <title>Background</title>
                <p>This study aims to provide an in-depth exploration of the effects of video and text computer tailoring on message-processing mechanisms, which are also tested within the currently tested RCT [<xref ref-type="bibr" rid="ref35">35</xref>]. Hence, the sample and the study we describe in this paper are different from the currently tested RCT. The described study uses only one session of the intervention tested within the RCT to test a different hypothesis (ie, differences between video/text on outcome measures regarding message-processing mechanisms and future adherence, which are not directly related to health, and not the hypothesis stated in the RCT protocol concerning the effect on smoking cessation) and was therefore not registered as a trial.</p>
            </sec>
            <sec>
                <title>Sample</title>
                <p>Participants for this study were recruited in May 2011 through the Dutch Internet research agency Flycatcher [<xref ref-type="bibr" rid="ref36">36</xref>]. From this panel, a sample of potential participants (N=11,583) was approached to fill in a short web-based questionnaire about their smoking behavior, their motivation to quit, and their educational level. The main purpose of this pre-analysis was to include participants who smoked only at the time of the study inclusion, were aged 16 years or older, were motivated to quit, and could be categorized as lower or higher educated participants. They were first asked to indicate whether they smoked. Participants who indicated they smoke were next asked to indicate how often they smoked ranging from daily to once a month or less. Motivation to quit smoking was measured by one item assessing whether the participant intended to quit smoking in the future on an 8-item scale ranging from &#8220;definitely not&#8221; (1) to &#8220;definitely yes&#8221; (8). All participants who at least indicated that they were most likely (6) to quit in the near future were categorized as motivated. Educational level was divided into low (primary, basic vocational, lower general school), intermediate (higher general secondary education, preparatory academic education, medium vocational school) and high (higher vocational school or university level). Only participants with a low or high educational level (categorized to the standards of Statistics Netherlands) were invited to take part in the study [<xref ref-type="bibr" rid="ref37">37</xref>]. In total, a random sample of panel members (N=300) who met these inclusion criteria was invited to participate in the study.</p>
                <p>From this sample, 240 clicked on the link of the intervention website and agreed to participate in the study (response rate: 80%); 36 participants did not fill out the questionnaire resulting in a sample of 204 participants who finished the study (retention rate: 85%). From these 204, only smokers who stayed more than 5 minutes on the intervention website (n=139) were included in the main analysis. We used this inclusion criterion since a minimum of 5 minutes is needed to process the information in both conditions. In order test our hypotheses on message-processing mechanisms and future adherence correctly, we found it necessary to include only smokers who thoroughly completed the program. This resulted in a sample of 139 participants (see <xref ref-type="fig" rid="figure1">Figure 1</xref>). As an additional strategy, we also conducted an intention-to-treat analysis of the data from all participants, also including those who stayed less than 5 minutes on the website.</p>
                <fig id="figure1" position="float">
                    <label>Figure 1</label>
                    <caption>
                        <p>Flowchart of the study.</p>
                    </caption>
                    <graphic xlink:href="jmir_v15i2e28_fig1.jpg" alt-version="no" mimetype="image" position="float" xlink:type="simple" />
                </fig>
            </sec>
            <sec>
                <title>Procedure</title>
                <p>After signing up for participation and giving online informed consent, all included smokers were exposed to the website of a Dutch smoking cessation computer-tailored intervention [<xref ref-type="bibr" rid="ref38">38</xref>]. Participants were informed that they were able to discontinue their participation in the study at any time without any consequences. Smokers were randomly allocated to either the text condition or the video condition. Allocation to the two conditions was executed by the Tailor Builder computer software program (OSE, Sittard, the Netherlands). This software was developed for the execution of different web-based tailored interventions [<xref ref-type="bibr" rid="ref39">39</xref>]. Smokers had to follow only one session of the currently tested computer-tailored smoking cessation intervention. After completing this session, they were asked to fill out a web-based questionnaire assessing message-processing mechanisms and the intention to revisit the website and recommend it to others.</p>
            </sec>
            <sec>
                <title>Content</title>
                <sec>
                    <title>Intervention</title>
                    <p>The computer-tailored smoking cessation intervention was based on the I-Change model [<xref ref-type="bibr" rid="ref40">40</xref>]. Participants in the text condition received computer-tailored text messages, whereas participants in the video condition received computer-tailored video messages. In the text condition, participants were presented text phrases without any further graphics or animations. For the video condition, the text-driven messages were translated into narrated video-driven messages that had a news-driven format with different adults delivering the tailored messages. We used simple videos without any other animation effects such as cartoons, hyperlinks, etc. In the video condition, the same tailored advice was used as in the text condition. The only difference between the two conditions was the strategy of delivery; the content of the advice was the same in both conditions (see <xref ref-type="fig" rid="figure2">Figures 2</xref> and <xref ref-type="fig" rid="figure3">3</xref>) Feedback messages were based on a participant&#8217;s answers to a questionnaire and tailored to their individual characteristics, such as their beliefs towards smoking, their intention to quit, and their overall smoking behavior. The session that smokers had to follow in this study was intended to increase participants&#8217; motivation to quit smoking and to encourage smokers to quit smoking in the near future. First, smokers received three tailored feedback messages on their perceived advantages and disadvantages of quitting. Next, one piece of advice was offered with respect to participants&#8217; perceived social support. Last, one piece of tailored advice was provided on their perceived self-efficacy to quit smoking. A detailed description of the different intervention components that are assessed in the currently tested RCT are reported elsewhere [<xref ref-type="bibr" rid="ref35">35</xref>].</p>
                    <fig id="figure2" position="float">
                        <label>Figure 2</label>
                        <caption>
                            <p>Screenshot of personal advice from the video condition.</p>
                        </caption>
                        <graphic xlink:href="jmir_v15i2e28_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple" />
                    </fig>
                    <fig id="figure3" position="float">
                        <label>Figure 3</label>
                        <caption>
                            <p>Screenshot of personal advice from the text condition.</p>
                        </caption>
                        <graphic xlink:href="jmir_v15i2e28_fig3.png" alt-version="no" mimetype="image" position="float" xlink:type="simple" />
                    </fig>
                </sec>
                <sec>
                    <title>Measures</title>
                    <p>The following demographic variables were measured: age, gender (0=male; 1=female), and educational level (0=low; 1=high) [<xref ref-type="bibr" rid="ref37">37</xref>]. Furthermore, time spent on the intervention website was logged by the program system in minutes and seconds.</p>
                    <p>
                        <italic>Addiction level</italic> was measured by 6 items using the Fagerstr&#246;m Test for Nicotine Dependence (FTND), asking participants how many cigarettes they smoked per day, at which time points, and whether they had difficulties not smoking in smoke-free places. The answers were converted into an overall sum score (0=not addicted; 10=highly addicted) [<xref ref-type="bibr" rid="ref41">41</xref>].</p>
                    <p>
                        <italic>Readiness to quit smoking</italic> was measured by one item asking participants whether they intended to quit smoking, resulting in 6 categories (6=yes, within the following month; 5=yes, within 1-3 months; 4=yes, within 4-6 months; 3=yes, within 1 year; 2=yes, within 1-5 years; 1=yes, but not within the following 5 years) [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref43">43</xref>].</p>
                    <p>
                        <italic>Cognitive processing</italic> (eg, &#8220;I like tasks where I do not have to think much&#8221;, assessing to what extent people engage in effortful processing) was measured by 6 items on a 5-point scale of the Heuristic Systematic Processing Questionnaire ranging from 5, &#8220;I totally agree&#8221; to 1, &#8220;I totally disagree&#8221; (Cronbach alpha=.74) [<xref ref-type="bibr" rid="ref44">44</xref>].</p>
                    <p>Future adherence was measured by two concepts: intention and recommendation. <italic>Intention to revisit</italic> (eg, &#8220;It is likely that I will visit the website again in the future&#8221;) was measured by 3 items on a 7-point scale, ranging from 7, &#8220;I totally agree&#8221; to 1, &#8220;I totally disagree&#8221; (Cronbach alpha=.91). <italic>Recommendation</italic> to others (eg, &#8220;It is likely that I will recommend this website to others&#8221;) was measured by 3 items on a 7-point scale ranging from 7, &#8220;I totally agree&#8221; to 1, &#8220;I totally disagree&#8221; (Cronbach alpha=.97) [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref45">45</xref>].</p>
                    <p>User experiences (also known as user perceptions) [<xref ref-type="bibr" rid="ref30">30</xref>] were measured by four concepts: trustworthiness, enjoyment, active trust, and design aesthetic. <italic>Trustworthiness</italic> (eg, &#8220;I trust the information presented on this website&#8221;) was measured by 3 items on a 7-point scale ranging from 7, &#8220;I totally agree&#8221; to 1, &#8220;I totally disagree&#8221; (Cronbach alpha=.87). <italic>Enjoyment</italic> (eg, &#8220;I found my visit to this website enjoyable&#8221;) was measured by 3 items on a 7-point scale ranging from 7, &#8220;I totally agree&#8221; to 1, &#8220;I totally disagree&#8221; (Cronbach alpha=.92). <italic>Active trust</italic> (eg, &#8220;I would act on the information presented on this website if needed&#8221;) was measured by 3 items on a 7-point scale ranging from 7, &#8220;I totally agree&#8221; to 1,&#8220;I totally disagree&#8221; (Cronbach alpha=.91). <italic>Design aesthetic</italic> (eg, &#8220;The whole design of the website/program is attractive&#8221;) was measured by 3 items on a 7-point scale ranging from 7, &#8220;I totally agree&#8221; to 1, &#8220;I totally disagree&#8221; (Cronbach alpha=.93) [<xref ref-type="bibr" rid="ref30">30</xref>].</p>
                    <p>Tailored-processing mechanisms were measured by five concepts. <italic>Attention</italic> for the tailored advice (eg, &#8220;The advice was interesting&#8221;) was measured by 4 items on a 7-point scale ranging from 7, &#8220;I totally agree&#8221; to 1, &#8220;I totally disagree&#8221; (Cronbach alpha=.89). <italic>Comprehension</italic> of the advice (eg, &#8220;The advice was clear to me&#8221;) was measured by 4 items on a 7-point scale ranging from 7, &#8220;I totally agree&#8221; to 1, &#8220;I totally disagree&#8221; (Cronbach alpha=.91). <italic>Self-reference</italic> towards the advice (eg, &#8220;The advice was personally relevant for me&#8221;) was measured by 4 items on a 7-point scale ranging from 7, &#8220;I totally agree&#8221; to 1, &#8220;I totally disagree&#8221; (Cronbach alpha=.91). <italic>Appreciation</italic> of the advice (eg, &#8220;I appreciated the advice&#8221;) was measured by 3 items on a 7-point scale ranging from 7, &#8220;I totally agree&#8221; to 1, &#8220;I totally disagree&#8221; (Cronbach alpha=.94). <italic>Processing</italic> of the advice (eg, &#8220;The advice encouraged me to think more about smoking cessation&#8221;) was measured by 4 items on a 7-point scale ranging from 7, &#8220;I totally agree&#8221; to 1, &#8220;I totally disagree&#8221; (Cronbach alpha=.93) [<xref ref-type="bibr" rid="ref21">21</xref>].</p>
                    <p>An overall grade for the advice was measured by 1 item asking participants to give an overall score for the provided advice from 1 (very bad) to 10 (very good).</p>
                </sec>
            </sec>
            <sec>
                <title>Statistical Analysis</title>
                <p>First, descriptive analyses were used to determine the sample&#8217;s characteristics. To test whether any baseline differences existed between the video and text condition, <italic>t</italic> tests were performed for interval scaled variables, whereas Chi-square tests were conducted for categorical variables. Additionally, the same analyses were executed to investigate whether baseline differences existed between higher educated and lower educated participants. Those variables that differed between condition and educational levels were included as covariates in all further analyses.</p>
                <p>Second, two-way analyses of co-variance (ANCOVA) were carried out to assess whether any differences existed in message-processing mechanisms according to delivery strategy and educational level. The same analyses were executed to detect any differences in future adherence according to delivery strategy and educational level.</p>
                <p>Last, a linear regression analysis was conducted to determine the unique predictive power of delivery strategy and educational level on future adherence when user experiences were included as independent predictors in the analysis. All analyses were conducted with SPSS 17.0.</p>
                <p>In the main analyses, we used the sample of the 139 participants who stayed more than 5 minutes on the intervention website. These analyses were repeated using an intention-to-treat analysis of the data from all 204 participants to verify whether we did not introduce a selection bias by our restriction criterion.</p>
            </sec>
        </sec>
        <sec sec-type="results">
            <title>Results</title>
            <sec>
                <title>Sample Characteristics</title>
                <p>There were no significant differences between participants in the video and text condition with regard to gender, educational level, age, cognitive processing, addiction level, and intention to quit smoking.</p>
                <p>Participants in the video condition spent more time on the website in comparison with participants in the text condition (<italic>t</italic> (137) =5.06, <italic>P</italic>&#60;.001), most probably due to the fact that the video condition lasted slightly longer than the text condition. Age of participants included in the analysis varied from 20 to 72 years (mean 47.39; SD 11.94). Overall, men were slightly underrepresented (37.4%). A description of the overall sample at baseline can be found in <xref ref-type="table" rid="table1">Table 1</xref>.</p>
                <table-wrap position="float" id="table1">
                    <label>Table 1</label>
                    <caption>
                        <p>Sample characteristics of adult Dutch smokers (N=139).</p>
                    </caption>
                    <table width="615" border="1" cellpadding="7" cellspacing="0" rules="groups" frame="hsides">
                        <col width="98" />
                        <col width="109" />
                        <col width="90" />
                        <col width="90" />
                        <col width="99" />
                        <col width="42" />
                        <thead>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>Overall sample</td>
                                <td>Text condition</td>
                                <td>Video condition</td>
                                <td>
                                    <italic>P</italic>
                                </td>
                            </tr>
                        </thead>
                        <tbody>
                            <tr valign="top">
                                <td>
                                    <bold>Gender, n (%)</bold>
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>.42</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Female</td>
                                <td>87 (62.6 %)</td>
                                <td>44 (59.5%)</td>
                                <td>43 (66.2%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Male</td>
                                <td>52 (37.4%)</td>
                                <td>30 (40.5%)</td>
                                <td>22 (33.8%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <bold>Educational level, n (%)</bold>
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>.45</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Low</td>
                                <td>68 (48.9%)</td>
                                <td>34 (45.9%)</td>
                                <td>34 (52.3%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>High</td>
                                <td>71 (51.1%)</td>
                                <td>40 (54.1%)</td>
                                <td>31 (47.7%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <bold>Age, mean (SD)</bold>
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>47.39 (11.94)</td>
                                <td>46.66 (11.90)</td>
                                <td>48.22 (12.03)</td>
                                <td>.45</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <bold>Cognitive processing, mean (SD)</bold>
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>3.56 (0.61)</td>
                                <td>3.55 (0.62)</td>
                                <td>3.57 (0.60)</td>
                                <td>.83</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <bold>FTND score (1-10), mean (SD)</bold>
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>3.57 (2.54)</td>
                                <td>3.41 (2.52)</td>
                                <td>3.75 (2.57)</td>
                                <td>.43</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <bold>Readiness to quit, n (%)</bold>
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>.93</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Within 1 month</td>
                                <td>26 (18.8%)</td>
                                <td>14 (19.2%)</td>
                                <td>12 (18.5%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Within 1-3 months</td>
                                <td>43 (31.25%)</td>
                                <td>22 (30.1%)</td>
                                <td>21 (32.3%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Within 4-6 months</td>
                                <td>28 (20.3%)</td>
                                <td>14 (19.2%)</td>
                                <td>14 (21.5%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Within 1 year</td>
                                <td>24 (17.4%)</td>
                                <td>12 (16.4%)</td>
                                <td>12 (18.5%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Within 1-5 years</td>
                                <td>15 (10.9%)</td>
                                <td>10 (13.7%)</td>
                                <td>5 (33.3%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>After 5 years</td>
                                <td>2 (1.4%)</td>
                                <td>1 (1.4%)</td>
                                <td>1 (1.5%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <bold>Time spent on website (min), mean (SD)</bold>
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>8.11 (12.82%)</td>
                                <td>7.15 (9.82%)</td>
                                <td>7.81 (16.24%)</td>
                                <td>&#60; .001</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>
                    <xref ref-type="table" rid="table2">Table 2</xref> shows that participants with either a high or low educational level did not differ with respect to condition, gender, readiness to quit smoking, and time spent on the website. However, educational level differed significantly with respect to age (<italic>t</italic> (137)=1.90; <italic>P</italic>=.05) and nicotine addiction (<italic>t</italic> (136)=4.69; <italic>P</italic>&#60;.001). Lower educated participants were older and more addicted to nicotine compared to higher educated participants. Participants with a higher educational level scored significantly higher on cognitive processing than those with a lower educational level (<italic>t</italic> (137)=-5.00; <italic>P</italic>&#60;.001).</p>
                <table-wrap position="float" id="table2">
                    <label>Table 2</label>
                    <caption>
                        <p>Differences of characteristics between lower and higher educational levels (N=139).</p>
                    </caption>
                    <table width="632" border="1" cellpadding="7" cellspacing="0" rules="groups" frame="hsides">
                        <col width="108" />
                        <col width="109" />
                        <col width="99" />
                        <col width="99" />
                        <col width="90" />
                        <col width="40" />
                        <thead>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>Overall sample</td>
                                <td>High level</td>
                                <td>Low level</td>
                                <td>
                                    <italic>P</italic>
                                </td>
                            </tr>
                        </thead>
                        <tbody>
                            <tr valign="top">
                                <td>
                                    <bold>Condition, n (%)</bold>
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>.45</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Text</td>
                                <td>74 (53.2%)</td>
                                <td>40 (56.3%)</td>
                                <td>34 (50.0%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Video</td>
                                <td>65 (46.8%)</td>
                                <td>31 (43.7%)</td>
                                <td>34 (50.0%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <bold>Gender, n (%)</bold>
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>.39</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Female</td>
                                <td>87 (62.6%)</td>
                                <td>42 (59.2%)</td>
                                <td>45 (66.2%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Male</td>
                                <td>52 (37.4%)</td>
                                <td>29 (20.9%)</td>
                                <td>23 (33.8%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <bold>Age, mean (SD)</bold>
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>47.39 (11.94)</td>
                                <td>45.52 (13.63)</td>
                                <td>49.34 (9.60)</td>
                                <td>.05</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <bold>Cognitive processing, mean (SD)</bold>
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>3.56 (0.61)</td>
                                <td>3.79 (0.56)</td>
                                <td>3.31 (0.57)</td>
                                <td>&#60;.001</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <bold>FTND score (1-10), mean (SD)</bold>
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>3.57 (2.54)</td>
                                <td>2.65 (2.45)</td>
                                <td>4.54 (2.27)</td>
                                <td>&#60;.001</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <bold>Readiness to quit, n (%)</bold>
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>.109</td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Within 1 month</td>
                                <td>26 (18.8)</td>
                                <td>17 (23.9%)</td>
                                <td>9 (13.4%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Within 1-3 months</td>
                                <td>43 (31.2%)</td>
                                <td>27 (38.0%)</td>
                                <td>16 (23.9%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Within 4-6 months</td>
                                <td>28 (20.3%)</td>
                                <td>12 (16.9%)</td>
                                <td>16 (23.9%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Within 1 year</td>
                                <td>24 (17.4%)</td>
                                <td>8 (11.3%)</td>
                                <td>16 (23.9%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>Within 1-5 years</td>
                                <td>15 (10.9%)</td>
                                <td>6 (8.5%)</td>
                                <td>9 (13.4%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <break />
                                </td>
                                <td>After 5 years</td>
                                <td>2 (1.4%)</td>
                                <td>1 (1.4%)</td>
                                <td>1 (1.5%)</td>
                                <td>
                                    <break />
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>
                                    <bold>Time spent on website, mean (SD)</bold>
                                </td>
                                <td>
                                    <break />
                                </td>
                                <td>12.82 (8.11)</td>
                                <td>13.49 (9.92)</td>
                                <td>12.13 (5.62)</td>
                                <td>.33</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec>
                <title>Differences in Message-Processing Mechanisms</title>
                <p>To test possible interaction effects of delivery strategy and educational level on message-processing mechanisms, ANOVAs were conducted using each of the five message-processing measures as dependent variables. For the five measures, no interaction effects were found between delivery strategy and educational level. Subsequently, main effects of delivery strategy were tested on message-processing measures. As shown in <xref ref-type="table" rid="table3">Table 3</xref>, none of the measures approached significance. Furthermore, main effects of educational level were tested on message-processing measures. As shown in <xref ref-type="table" rid="table4">Table 4</xref>, lower educated participants devoted more attention to the tailored advice compared to higher educated participants (<italic>F</italic>(1,138)=3.97; <italic>P</italic>=.05). Also, the extent to which participants processed the information was shown to be higher among lower educated groups (<italic>F</italic>(1,138)=4.58; <italic>P</italic>=.04). No differences between lower and higher educated smokers could be found with regard to understanding, self-reference, appreciation, and the overall grade for the advice.</p>
                <table-wrap position="float" id="table3">
                    <label>Table 3</label>
                    <caption>
                        <p>Differences in variances of delivery strategy with regard to message-processing mechanisms (N=139).</p>
                    </caption>
                    <table width="613" border="1" cellpadding="7" cellspacing="0" rules="groups" frame="hsides">
                        <col width="146" />
                        <col width="99" />
                        <col width="99" />
                        <col width="62" />
                        <col width="62" />
                        <col width="60" />
                        <thead>
                            <tr valign="top">
                                <td colspan="6">Delivery strategy</td>
                            </tr>
                            <tr valign="bottom">
                                <td>
                                    <break />
                                </td>
                                <td>Text group Mean (SD)</td>
                                <td>Video group Mean (SD)</td>
                                <td>F</td>
                                <td>
                                    <italic>P</italic>
                                </td>
                                <td>&#951;<sup>2</sup>
                                </td>
                            </tr>
                        </thead>
                        <tbody>
                            <tr valign="top">
                                <td>Attention</td>
                                <td>4.85 (1.43)</td>
                                <td>4.83 (1.28)</td>
                                <td>.00</td>
                                <td>.97</td>
                                <td>.000</td>
                            </tr>
                            <tr valign="top">
                                <td>Comprehension</td>
                                <td>5.50 (1.12)</td>
                                <td>5.41 (1.04)</td>
                                <td>1.15</td>
                                <td>.29</td>
                                <td>.008</td>
                            </tr>
                            <tr valign="top">
                                <td>Self-reference</td>
                                <td>4.93 (1.47)</td>
                                <td>4.97 (1.20)</td>
                                <td>.06</td>
                                <td>.81</td>
                                <td>.000</td>
                            </tr>
                            <tr valign="top">
                                <td>Appreciation</td>
                                <td>5.23 (1.43)</td>
                                <td>5.08 (1.32)</td>
                                <td>.40</td>
                                <td>.53</td>
                                <td>.003</td>
                            </tr>
                            <tr valign="top">
                                <td>Processing</td>
                                <td>4.56 (1.54)</td>
                                <td>4.83 (1.38)</td>
                                <td>.97</td>
                                <td>.33</td>
                                <td>.007</td>
                            </tr>
                            <tr valign="top">
                                <td>Grade advice</td>
                                <td>7.19 (1.36)</td>
                                <td>6.91 (1.56)</td>
                                <td>1.89</td>
                                <td>.17</td>
                                <td>.014</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <table-wrap position="float" id="table4">
                    <label>Table 4</label>
                    <caption>
                        <p>Differences in variances of socioeconomic status with regard to message-processing mechanisms (N=139).</p>
                    </caption>
                    <table width="613" border="1" cellpadding="7" cellspacing="0" rules="groups" frame="hsides">
                        <col width="146" />
                        <col width="99" />
                        <col width="99" />
                        <col width="62" />
                        <col width="62" />
                        <col width="60" />
                        <thead>
                            <tr valign="top">
                                <td colspan="6">Educational Level</td>
                            </tr>
                            <tr valign="bottom">
                                <td>
                                    <break />
                                </td>
                                <td>High level  <break />
                                </td>
                                <td>Low level Mean (SD)</td>
                                <td>F</td>
                                <td>
                                    <italic>P</italic>
                                </td>
                                <td>&#951;<sup>2</sup>
                                </td>
                            </tr>
                        </thead>
                        <tbody>
                            <tr valign="top">
                                <td>Attention</td>
                                <td>4.51 (1.46)</td>
                                <td>5.21 (1.14)</td>
                                <td>3.97</td>
                                <td>.05</td>
                                <td>.029</td>
                            </tr>
                            <tr valign="top">
                                <td>Comprehension</td>
                                <td>5.41 (1.16)</td>
                                <td>5.54 (0.98)</td>
                                <td>.02</td>
                                <td>.67</td>
                                <td>.001</td>
                            </tr>
                            <tr valign="top">
                                <td>Self-reference</td>
                                <td>4.74 (1.42)</td>
                                <td>5.19 (1.23)</td>
                                <td>2.10</td>
                                <td>.15</td>
                                <td>.016</td>
                            </tr>
                            <tr valign="top">
                                <td>Appreciation</td>
                                <td>4.88 (1.50)</td>
                                <td>5.47 (1.16)</td>
                                <td>1.75</td>
                                <td>.19</td>
                                <td>.013</td>
                            </tr>
                            <tr valign="top">
                                <td>Processing</td>
                                <td>4.32 (1.53)</td>
                                <td>5.09 (1.31)</td>
                                <td>4.58</td>
                                <td>.04</td>
                                <td>.033</td>
                            </tr>
                            <tr valign="top">
                                <td>Grade advice</td>
                                <td>6.92 (1.46)</td>
                                <td>7.21 (1.54)</td>
                                <td>1.45</td>
                                <td>.23</td>
                                <td>.011</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec>
                <title>Differences in Future Adherence</title>
                <p>To test for possible interaction effects of delivery strategy and educational level on future adherence, ANOVAs were conducted using each of the two measures as dependent variables. For both measures, interaction effects between delivery strategy and educational level were found to be insignificant. Next, main effects of delivery strategy were tested on future adherence. As shown in <xref ref-type="table" rid="table5">Table 5</xref>, the two measures did not approach significance. Furthermore, main effects of educational level on future adherence were conducted. As shown in <xref ref-type="table" rid="table6">Table 6</xref>, lower educated participants had a higher intention to visit the website again compared to participants with a higher educational level (<italic>F</italic>(1,138)=4.43; <italic>P</italic>=.04). Recommending the website to others did not differ among lower and higher educated smokers.</p>
                <table-wrap position="float" id="table5">
                    <label>Table 5</label>
                    <caption>
                        <p>Differences in variances of delivery strategy with regard to future adherence (N=139).</p>
                    </caption>
                    <table width="613" border="1" cellpadding="7" cellspacing="0" rules="groups" frame="hsides">
                        <col width="146" />
                        <col width="99" />
                        <col width="99" />
                        <col width="62" />
                        <col width="62" />
                        <col width="60" />
                        <thead>
                            <tr valign="top">
                                <td colspan="6">Delivery strategy</td>
                            </tr>
                            <tr valign="bottom">
                                <td>
                                    <break />
                                </td>
                                <td>Text group Mean (SD)</td>
                                <td>Video group Mean (SD)</td>
                                <td>F</td>
                                <td>
                                    <italic>P</italic>
                                </td>
                                <td>&#951;<sup>2</sup>
                                </td>
                            </tr>
                        </thead>
                        <tbody>
                            <tr valign="top">
                                <td>Intention</td>
                                <td>4.61 (1.58)</td>
                                <td>4.54 (1.61)</td>
                                <td>.00</td>
                                <td>.95</td>
                                <td>.000</td>
                            </tr>
                            <tr valign="top">
                                <td>Recommendation</td>
                                <td>4.65 (1.63)</td>
                                <td>4.74 (1.58)</td>
                                <td>.03</td>
                                <td>.87</td>
                                <td>.000</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <table-wrap position="float" id="table6">
                    <label>Table 6</label>
                    <caption>
                        <p>Differences in variances of socioeconomic status with regard to future adherence (N=139).</p>
                    </caption>
                    <table width="613" border="1" cellpadding="7" cellspacing="0" rules="groups" frame="hsides">
                        <col width="146" />
                        <col width="99" />
                        <col width="99" />
                        <col width="62" />
                        <col width="62" />
                        <col width="60" />
                        <thead>
                            <tr valign="top">
                                <td colspan="6">Educational level</td>
                            </tr>
                            <tr valign="bottom">
                                <td>
                                    <break />
                                </td>
                                <td>High level Mean (SD)</td>
                                <td>Low level Mean (SD)</td>
                                <td>F</td>
                                <td>
                                    <italic>P</italic>
                                </td>
                                <td>&#951;<sup>2</sup>
                                </td>
                            </tr>
                        </thead>
                        <tbody>
                            <tr valign="top">
                                <td>Intention</td>
                                <td>4.23 (1.76)</td>
                                <td>4.96 (1.28)</td>
                                <td>4.43</td>
                                <td>.04</td>
                                <td>.032</td>
                            </tr>
                            <tr valign="top">
                                <td>Recommendation</td>
                                <td>4.37 (1.72)</td>
                                <td>5.05 (1.41)</td>
                                <td>2.72</td>
                                <td>.10</td>
                                <td>.020</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec>
                <title>Predictors of Future Adherence</title>
                <p>In order to test whether delivery strategy, educational level, age, smoking dependency, cognitive processing, and time spent on the website were independent predictors of future adherence, multiple regression analysis was executed. User experiences were included as well as independent predictors in the analysis to determine the unique predictive power of delivery strategy and educational level in addition to user experiences. Therefore, the first model consisted of user experiences. Second, we investigated whether these results would change after controlling for delivery strategy, educational level, age, gender, and smoking behavior. Results of the multiple regression analysis are presented in <xref ref-type="table" rid="table7">Table 7</xref>. User experiences did not alter the observed results.</p>
                <table-wrap position="float" id="table7">
                    <label>Table 7</label>
                    <caption>
                        <p>Multiple regression analysis for future adherence (N=139).</p>
                    </caption>
                    <table width="613" border="1" cellpadding="7" cellspacing="0" rules="groups" frame="hsides">
                        <col width="240" />
                        <col width="166" />
                        <col width="164" />
                        <thead>
                            <tr valign="top">
                                <td>Predictor variable (Beta)</td>
                                <td>Intention</td>
                                <td>Recommendation</td>
                            </tr>
                        </thead>
                        <tbody>
                            <tr valign="top">
                                <td>Trustworthiness</td>
                                <td>-.145</td>
                                <td>-.093</td>
                            </tr>
                            <tr valign="top">
                                <td>Enjoyment</td>
                                <td>-.057</td>
                                <td>-.171</td>
                            </tr>
                            <tr valign="top">
                                <td>Active trust</td>
                                <td>-.544<sup>b</sup>
                                </td>
                                <td>-.487<sup>b</sup>
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>Design aesthetics</td>
                                <td>-.128</td>
                                <td>-.158<sup>b</sup>
                                </td>
                            </tr>
                            <tr valign="top">
                                <td>Condition</td>
                                <td>-.053</td>
                                <td>-.010</td>
                            </tr>
                            <tr valign="top">
                                <td>SES</td>
                                <td>-.156</td>
                                <td>-.032</td>
                            </tr>
                            <tr valign="top">
                                <td>Age</td>
                                <td>-.086</td>
                                <td>.017</td>
                            </tr>
                            <tr valign="top">
                                <td>Gender</td>
                                <td>-.061</td>
                                <td>-.028</td>
                            </tr>
                            <tr valign="top">
                                <td>Smoking dependency</td>
                                <td>-.008</td>
                                <td>-.015</td>
                            </tr>
                            <tr valign="top">
                                <td>Cognitive processing</td>
                                <td>.015</td>
                                <td>-.033</td>
                            </tr>
                            <tr valign="top">
                                <td>Time on the website</td>
                                <td>.006</td>
                                <td>.075</td>
                            </tr>
                            <tr valign="top">
                                <td>R square</td>
                                <td>.697</td>
                                <td>.721</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <fn id="table7fn1">
                            <p>
                                <sup>a</sup>
                                <italic>P</italic>&#60;.01.</p>
                        </fn>
                        <fn id="table7fn2">
                            <p>
                                <sup>b</sup>
                                <italic>P</italic>&#60;.05.</p>
                        </fn>
                    </table-wrap-foot>
                </table-wrap>
            </sec>
            <sec>
                <title>Intention-to-Treat Analysis</title>
                <p>The intention-to-treat analysis revealed no different results with regard to sample characteristics. For both, message-processing mechanisms and future adherence interaction effects between delivery strategy and educational level were found to be insignificant. Next, main effects of delivery strategy and educational level were tested on message-processing mechanisms and future adherence. We found a significant difference between the two message methods only regarding the concept of comprehension. Participants in the text condition showed a higher comprehension of the tailored messages compared to people in the video condition (<italic>F</italic>(1,201)=4.34; <italic>P</italic>=.04). However, the results of this analysis should be carefully interpreted since people staying less than 5 minutes on the website could not possibly have read the advice in-depth.</p>
            </sec>
        </sec>
        <sec sec-type="discussion">
            <title>Discussion</title>
            <p>The first objective of the present study was to investigate whether differences exist in message-processing mechanisms according to delivery strategy and education level for a computer-tailored smoking cessation intervention. Results revealed that delivery strategy did not interact with education on message-processing mechanisms. This means that delivery strategy had no influence on the processing of the message by participants with different educational levels. Moreover, the processing of the tailored information did not differ between the two conditions. The idea that the processing of computer-tailored information would depend on the delivery strategy did not hold for this computer-tailored intervention. This conclusion is in line with results found in a recent study concerning physical activity, which demonstrated no differences between video- and text-generated computer-tailored messages [<xref ref-type="bibr" rid="ref46">46</xref>]. One explanation for these findings may be the exposure time of the intervention. Participants may have needed to follow more than one session of the intervention in order to detect differences between the two delivery modes. Next, our findings revealed that lower educated smokers paid more attention to the tailored advice and seemed to process information more deeply. As such, lower educated smokers seemed to be more involved in the computer-tailored intervention than higher educated smokers. The findings imply that the current intervention session succeeded in approaching those smokers in the general population who might profit the most from these computer-tailored interventions. Our findings correspond with those from a recent study that found that lower educated participants were more likely to finish a module of a computer-tailored lifestyle intervention [<xref ref-type="bibr" rid="ref47">47</xref>]. We did not find other differences between educational groups with respect to the other message-processing mechanisms: comprehension, self-reference, and appreciation, which is contrary to previous research that did find higher appreciation rates of computer-tailored advice among lower educated participants [<xref ref-type="bibr" rid="ref48">48</xref>].</p>
            <p>The second objective of this study was to examine whether differences exist in future adherence (intention to revisit, recommend the website to others) with regard to delivery strategy and education. The results revealed no interaction between delivery strategy and education on the intention to adhere; implying that a different delivery strategy did not influence future adherence of lower and higher educated smokers. Again, delivery strategy was found to have no particular effect on future adherence. However, the results demonstrated that lower educated smokers were more inclined to revisit the website compared to higher educated smokers. Although not significant, our findings revealed a slightly better appreciation of the website by lower educated participants, which may have contributed to the positive intention to revisit the website. As already mentioned, this is in line with findings of a previous study that lower educated participants were more inclined to initiate a lifestyle program [<xref ref-type="bibr" rid="ref47">47</xref>]. Additionally, our lower educated participants were slightly less motivated (<italic>P</italic>&#60;.11) to quit immediately, which also could explain a need for continued help to prepare them to quit in the future. Although lower educated smokers were more inclined to visit the website again, we could not find any educational differences with regard to recommending the website to others. As the results indicate that the &#8220;word of mouth&#8221;&#8217; strategy might be not sufficient to recruit participants for Internet interventions, other recruitment strategies may also be needed such as recruitment through general practitioners [<xref ref-type="bibr" rid="ref49">49</xref>]. A question raised by our results is why delivery strategy did not influence message-processing mechanisms and future adherence among different educational groups. One explanation could be that we recruited persons via an Internet research agency, which may have more innovative members that have already an open mind to Internet interventions. It might be possible that for those people, delivery mode did not differ that much. It is conceivable that delivery mode preference might have been different if we had recruited participants via other strategies, eg, newspaper advertisements. Furthermore, it might be possible that participants were not engaged by the design of the intervention components. The two conditions might have been presented in a more engaging way with further images, graphics, hyperlinks, and other animation effects. However, an important precondition for our experimental design was that the information of the video condition was contingent on the information provided by text condition to reveal the added effect of presenting information through a video format.</p>
            <p>Our findings reveal that the tailored advice given was more positively evaluated by lower educated smokers. This outcome is in contrast with earlier studies indicating that web-based programs may result in a digital divide between lower and higher educated groups. Perhaps high Internet use among the Dutch (over 90%) may explain these effects [<xref ref-type="bibr" rid="ref37">37</xref>]. Moreover, since our less educated smokers often show higher addiction rates, fewer quit attempts, and more relapses [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>], approaching them via Internet may have added potential.</p>
            <sec>
                <title>Study Limitations</title>
                <p>The present study is subject to certain limitations. First, as with many health communication studies, we could not objectively assess quality of information processing as we could not measure it. Yet we did assess how long participants stayed on the website via server registrations and therefore could exclude all participants who briefly visited the intervention website and probably did not accurately process the given information. Second, our sample size was limited. Additional longitudinal research with a larger sample size is needed to investigate the role of delivery strategy in tailored information and to examine whether smokers will actually revisit the website and whether this will result in the ultimate goal of behavior change.</p>
            </sec>
            <sec>
                <title>Conclusions</title>
                <p>Delivery strategy did not play a role in the processing of the tailored information. Lower educated participants showed higher attention and processing levels. Lower educated participants were also more inclined to visit the intervention website again compared to higher educated participants. Due to the fact that all participants were members of an Internet research panel, the results can be applied only to people who are already regularly using the Internet. This study can be seen as an important first step to assess the influence of delivery strategy among different educational groups and especially among lower educated smokers in the Netherlands. Effective smoking cessation interventions are important to decreasing the gap between lower and higher educated smokers. Yet, longitudinal studies with larger sample sizes are needed to see whether these counterintuitive findings still hold true and to further assess additional aspects that we could not assess, such as actual revisit and long-term behavioral effects of the two strategies among lower and higher educated smokers in order to improve computer-tailored smoking cessation interventions.</p>
            </sec>
        </sec>
    </body>
    <back>
        <ack>
            <p>The study was funded by ZonMw, the Netherlands Organization for Health Research and Development (grant number: 20011007). The second author was supported by the Innovational Research Incentives Scheme Veni from NWO-MaGW (Netherlands Organization for Scientific Research, Division for the Social Sciences).</p>
        </ack>
        <fn-group>
            <fn fn-type="conflict">
                <p>Hein de Vries is scientific director of Vision2-Health, a company that licenses evidence-based innovative computer-tailored health communication tools.</p>
            </fn>
        </fn-group>
        <ref-list>
            <ref id="ref1">
                <label>1</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Leung</surname>
                            <given-names>L</given-names>
                        </name>
                    </person-group>
                    <article-title>Internet embeddedness: links with online health information seeking, expectancy value/quality of health information websites, and Internet usage patterns</article-title>
                    <source>Cyberpsychol Behav</source>
                    <year>2008</year>
                    <month>10</month>
                    <volume>11</volume>
                    <issue>5</issue>
                    <fpage>565</fpage>
                    <lpage>9</lpage>
                    <pub-id pub-id-type="doi">10.1089/cpb.2007.0189</pub-id>
                    <pub-id pub-id-type="medline">18771393</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref2">
                <label>2</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Oenema</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Brug</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Dijkstra</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Weerdt</surname>
                            <given-names>I</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>H</given-names>
                        </name>
                    </person-group>
                    <article-title>Efficacy and use of an internet-delivered computer-tailored lifestyle intervention, targeting saturated fat intake, physical activity and smoking cessation: a randomized controlled trial</article-title>
                    <source>Ann Behav Med</source>
                    <year>2008</year>
                    <month>04</month>
                    <volume>35</volume>
                    <issue>2</issue>
                    <fpage>125</fpage>
                    <lpage>35</lpage>
                    <pub-id pub-id-type="doi">10.1007/s12160-008-9023-1</pub-id>
                    <pub-id pub-id-type="medline">18363076</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref3">
                <label>3</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Te Poel</surname>
                            <given-names>F</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bolman</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Reubsaet</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>H</given-names>
                        </name>
                    </person-group>
                    <article-title>Efficacy of a single computer-tailored e-mail for smoking cessation: results after 6 months</article-title>
                    <source>Health Educ Res</source>
                    <year>2009</year>
                    <month>12</month>
                    <volume>24</volume>
                    <issue>6</issue>
                    <fpage>930</fpage>
                    <lpage>40</lpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://her.oxfordjournals.org/cgi/pmidlookup?view=long&#38;pmid=19574405" />
                    </comment>
                    <pub-id pub-id-type="doi">10.1093/her/cyp036</pub-id>
                    <pub-id pub-id-type="medline">19574405</pub-id>
                    <pub-id pub-id-type="pii">cyp036</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref4">
                <label>4</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Oenema</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Brug</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Lechner</surname>
                            <given-names>L</given-names>
                        </name>
                    </person-group>
                    <article-title>Web-based tailored nutrition education: results of a randomized controlled trial</article-title>
                    <source>Health Educ Res</source>
                    <year>2001</year>
                    <month>12</month>
                    <volume>16</volume>
                    <issue>6</issue>
                    <fpage>647</fpage>
                    <lpage>60</lpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://her.oxfordjournals.org/cgi/pmidlookup?view=long&#38;pmid=11780705" />
                    </comment>
                    <pub-id pub-id-type="medline">11780705</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref5">
                <label>5</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Steele</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Mummery</surname>
                            <given-names>WK</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Dwyer</surname>
                            <given-names>T</given-names>
                        </name>
                    </person-group>
                    <article-title>Using the Internet to promote physical activity: a randomized trial of intervention delivery modes</article-title>
                    <source>J Phys Act Health</source>
                    <year>2007</year>
                    <month>07</month>
                    <volume>4</volume>
                    <issue>3</issue>
                    <fpage>245</fpage>
                    <lpage>60</lpage>
                    <pub-id pub-id-type="medline">17846455</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref6">
                <label>6</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Peels</surname>
                            <given-names>DA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>van Stralen</surname>
                            <given-names>MM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bolman</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Golsteijn</surname>
                            <given-names>RH</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Mudde</surname>
                            <given-names>AN</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Lechner</surname>
                            <given-names>L</given-names>
                        </name>
                    </person-group>
                    <article-title>Development of web-based computer-tailored advice to promote physical activity among people older than 50 years</article-title>
                    <source>J Med Internet Res</source>
                    <year>2012</year>
                    <volume>14</volume>
                    <issue>2</issue>
                    <fpage>e39</fpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2012/2/e39/" />
                    </comment>
                    <pub-id pub-id-type="doi">10.2196/jmir.1742</pub-id>
                    <pub-id pub-id-type="medline">22390878</pub-id>
                    <pub-id pub-id-type="pii">v14i2e39</pub-id>
                    <pub-id pub-id-type="pmcid">PMC3376526</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref7">
                <label>7</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Brug</surname>
                            <given-names>J</given-names>
                        </name>
                    </person-group>
                    <article-title>Computer-tailored interventions motivating people to adopt health promoting behaviours: introduction to a new approach</article-title>
                    <source>Patient Educ Couns</source>
                    <year>1999</year>
                    <month>02</month>
                    <volume>36</volume>
                    <issue>2</issue>
                    <fpage>99</fpage>
                    <lpage>105</lpage>
                    <pub-id pub-id-type="medline">10223015</pub-id>
                    <pub-id pub-id-type="pii">S073839919800127X</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref8">
                <label>8</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Dijkstra</surname>
                            <given-names>A</given-names>
                        </name>
                    </person-group>
                    <article-title>Working mechanisms of computer-tailored health education: evidence from smoking cessation</article-title>
                    <source>Health Educ Res</source>
                    <year>2005</year>
                    <month>10</month>
                    <volume>20</volume>
                    <issue>5</issue>
                    <fpage>527</fpage>
                    <lpage>39</lpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://her.oxfordjournals.org/cgi/pmidlookup?view=long&#38;pmid=15701665" />
                    </comment>
                    <pub-id pub-id-type="doi">10.1093/her/cyh014</pub-id>
                    <pub-id pub-id-type="medline">15701665</pub-id>
                    <pub-id pub-id-type="pii">cyh014</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref9">
                <label>9</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Civljak</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Sheikh</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Stead</surname>
                            <given-names>LF</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Car</surname>
                            <given-names>J</given-names>
                        </name>
                    </person-group>
                    <article-title>Internet-based interventions for smoking cessation</article-title>
                    <source>Cochrane Database Syst Rev</source>
                    <year>2010</year>
                    <issue>9</issue>
                    <fpage>CD007078</fpage>
                    <pub-id pub-id-type="doi">10.1002/14651858.CD007078.pub3</pub-id>
                    <pub-id pub-id-type="medline">20824856</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref10">
                <label>10</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Myung</surname>
                            <given-names>SK</given-names>
                        </name>
                        <name name-style="western">
                            <surname>McDonnell</surname>
                            <given-names>DD</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kazinets</surname>
                            <given-names>G</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Seo</surname>
                            <given-names>HG</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Moskowitz</surname>
                            <given-names>JM</given-names>
                        </name>
                    </person-group>
                    <article-title>Effects of Web- and computer-based smoking cessation programs: meta-analysis of randomized controlled trials</article-title>
                    <source>Arch Intern Med</source>
                    <year>2009</year>
                    <month>05</month>
                    <day>25</day>
                    <volume>169</volume>
                    <issue>10</issue>
                    <fpage>929</fpage>
                    <lpage>37</lpage>
                    <pub-id pub-id-type="doi">10.1001/archinternmed.2009.109</pub-id>
                    <pub-id pub-id-type="medline">19468084</pub-id>
                    <pub-id pub-id-type="pii">169/10/929</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref11">
                <label>11</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Bennett</surname>
                            <given-names>GG</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Glasgow</surname>
                            <given-names>RE</given-names>
                        </name>
                    </person-group>
                    <article-title>The delivery of public health interventions via the Internet: actualizing their potential</article-title>
                    <source>Annu Rev Public Health</source>
                    <year>2009</year>
                    <volume>30</volume>
                    <fpage>273</fpage>
                    <lpage>92</lpage>
                    <pub-id pub-id-type="doi">10.1146/annurev.publhealth.031308.100235</pub-id>
                    <pub-id pub-id-type="medline">19296777</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref12">
                <label>12</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Eysenbach</surname>
                            <given-names>G</given-names>
                        </name>
                    </person-group>
                    <article-title>The law of attrition</article-title>
                    <source>J Med Internet Res</source>
                    <year>2005</year>
                    <volume>7</volume>
                    <issue>1</issue>
                    <fpage>e11</fpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2005/1/e11/" />
                    </comment>
                    <pub-id pub-id-type="doi">10.2196/jmir.7.1.e11</pub-id>
                    <pub-id pub-id-type="medline">15829473</pub-id>
                    <pub-id pub-id-type="pii">v7e11</pub-id>
                    <pub-id pub-id-type="pmcid">PMC1550631</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref13">
                <label>13</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Nagelhout</surname>
                            <given-names>GE</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Korte-de Boer</surname>
                            <given-names>D</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kunst</surname>
                            <given-names>AE</given-names>
                        </name>
                        <name name-style="western">
                            <surname>van der Meer</surname>
                            <given-names>RM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>van Gelder</surname>
                            <given-names>BM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Willemsen</surname>
                            <given-names>MC</given-names>
                        </name>
                    </person-group>
                    <article-title>Trends in socioeconomic inequalities in smoking prevalence, consumption, initiation, and cessation between 2001 and 2008 in the Netherlands. Findings from a national population survey</article-title>
                    <source>BMC Public Health</source>
                    <year>2012</year>
                    <volume>12</volume>
                    <fpage>303</fpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.biomedcentral.com/1471-2458/12/303" />
                    </comment>
                    <pub-id pub-id-type="doi">10.1186/1471-2458-12-303</pub-id>
                    <pub-id pub-id-type="medline">22537139</pub-id>
                    <pub-id pub-id-type="pii">1471-2458-12-303</pub-id>
                    <pub-id pub-id-type="pmcid">PMC3356226</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref14">
                <label>14</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Brouwer</surname>
                            <given-names>W</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Oenema</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Raat</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Crutzen</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Nooijer</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>NK</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Brug</surname>
                            <given-names>J</given-names>
                        </name>
                    </person-group>
                    <article-title>Characteristics of visitors and revisitors to an Internet-delivered computer-tailored lifestyle intervention implemented for use by the general public</article-title>
                    <source>Health Educ Res</source>
                    <year>2010</year>
                    <month>08</month>
                    <volume>25</volume>
                    <issue>4</issue>
                    <fpage>585</fpage>
                    <lpage>95</lpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://her.oxfordjournals.org/cgi/pmidlookup?view=long&#38;pmid=19897515" />
                    </comment>
                    <pub-id pub-id-type="doi">10.1093/her/cyp063</pub-id>
                    <pub-id pub-id-type="medline">19897515</pub-id>
                    <pub-id pub-id-type="pii">cyp063</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref15">
                <label>15</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Hiscock</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Judge</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bauld</surname>
                            <given-names>L</given-names>
                        </name>
                    </person-group>
                    <article-title>Social inequalities in quitting smoking: what factors mediate the relationship between socioeconomic position and smoking cessation?</article-title>
                    <source>J Public Health (Oxf)</source>
                    <year>2011</year>
                    <month>03</month>
                    <volume>33</volume>
                    <issue>1</issue>
                    <fpage>39</fpage>
                    <lpage>47</lpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://jpubhealth.oxfordjournals.org/cgi/pmidlookup?view=long&#38;pmid=21178184" />
                    </comment>
                    <pub-id pub-id-type="doi">10.1093/pubmed/fdq097</pub-id>
                    <pub-id pub-id-type="medline">21178184</pub-id>
                    <pub-id pub-id-type="pii">fdq097</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref16">
                <label>16</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Nielsen</surname>
                            <given-names>E</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Sheppard</surname>
                            <given-names>MA</given-names>
                        </name>
                    </person-group>
                    <article-title>Television as a patient education tool: a review of its effectiveness</article-title>
                    <source>Patient Educ Couns</source>
                    <year>1988</year>
                    <month>02</month>
                    <volume>11</volume>
                    <issue>1</issue>
                    <fpage>3</fpage>
                    <lpage>16</lpage>
                    <pub-id pub-id-type="medline">10302261</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref17">
                <label>17</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Houts</surname>
                            <given-names>PS</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Doak</surname>
                            <given-names>CC</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Doak</surname>
                            <given-names>LG</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Loscalzo</surname>
                            <given-names>MJ</given-names>
                        </name>
                    </person-group>
                    <article-title>The role of pictures in improving health communication: a review of research on attention, comprehension, recall, and adherence</article-title>
                    <source>Patient Educ Couns</source>
                    <year>2006</year>
                    <month>05</month>
                    <volume>61</volume>
                    <issue>2</issue>
                    <fpage>173</fpage>
                    <lpage>90</lpage>
                    <pub-id pub-id-type="doi">10.1016/j.pec.2005.05.004</pub-id>
                    <pub-id pub-id-type="medline">16122896</pub-id>
                    <pub-id pub-id-type="pii">S0738-3991(05)00146-1</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref18">
                <label>18</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Salomon</surname>
                            <given-names>G</given-names>
                        </name>
                    </person-group>
                    <article-title>Television Is Easy and Print is Tough: The differences investment of mental effort in learning as a function of perceptions and attributions</article-title>
                    <source>Journal of Education Psychology</source>
                    <year>1984</year>
                    <volume>76</volume>
                    <issue>4</issue>
                    <fpage>647</fpage>
                    <lpage>658</lpage>
                </nlm-citation>
            </ref>
            <ref id="ref19">
                <label>19</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Salomon</surname>
                            <given-names>G</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Gardner</surname>
                            <given-names>H</given-names>
                        </name>
                    </person-group>
                    <article-title>The computer as educator: Lessons from television research</article-title>
                    <source>Educational Researcher</source>
                    <year>1986</year>
                    <volume>15</volume>
                    <issue>1</issue>
                    <fpage>13</fpage>
                    <lpage>17</lpage>
                </nlm-citation>
            </ref>
            <ref id="ref20">
                <label>20</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Soetens</surname>
                            <given-names>KCM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Vandelanotte</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Mummery</surname>
                            <given-names>KW</given-names>
                        </name>
                    </person-group>
                    <article-title>Using online computer tailoring to promote physical activity: a randomized trial of text, video and combined intervention delivery-modes</article-title>
                    <source>Journal of Health Communication</source>
                    <year>2013</year>
                    <comment>(forthcoming)</comment>
                </nlm-citation>
            </ref>
            <ref id="ref21">
                <label>21</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Hawkins</surname>
                            <given-names>RP</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kreuter</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Resnicow</surname>
                            <given-names>K</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Fishbein</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Dijkstra</surname>
                            <given-names>A</given-names>
                        </name>
                    </person-group>
                    <article-title>Understanding tailoring in communicating about health</article-title>
                    <source>Health Educ Res</source>
                    <year>2008</year>
                    <month>06</month>
                    <volume>23</volume>
                    <issue>3</issue>
                    <fpage>454</fpage>
                    <lpage>66</lpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://her.oxfordjournals.org/cgi/pmidlookup?view=long&#38;pmid=18349033" />
                    </comment>
                    <pub-id pub-id-type="doi">10.1093/her/cyn004</pub-id>
                    <pub-id pub-id-type="medline">18349033</pub-id>
                    <pub-id pub-id-type="pii">cyn004</pub-id>
                    <pub-id pub-id-type="pmcid">PMC3171505</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref22">
                <label>22</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Kessels</surname>
                            <given-names>LT</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ruiter</surname>
                            <given-names>RA</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Brug</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Jansma</surname>
                            <given-names>BM</given-names>
                        </name>
                    </person-group>
                    <article-title>The effects of tailored and threatening nutrition information on message attention. Evidence from an event-related potential study</article-title>
                    <source>Appetite</source>
                    <year>2011</year>
                    <month>02</month>
                    <volume>56</volume>
                    <issue>1</issue>
                    <fpage>32</fpage>
                    <lpage>8</lpage>
                    <pub-id pub-id-type="doi">10.1016/j.appet.2010.11.139</pub-id>
                    <pub-id pub-id-type="medline">21094195</pub-id>
                    <pub-id pub-id-type="pii">S0195-6663(10)00686-0</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref23">
                <label>23</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Skinner</surname>
                            <given-names>CS</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Strecher</surname>
                            <given-names>VJ</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Hospers</surname>
                            <given-names>H</given-names>
                        </name>
                    </person-group>
                    <article-title>Physicians' recommendations for mammography: do tailored messages make a difference?</article-title>
                    <source>Am J Public Health</source>
                    <year>1994</year>
                    <month>01</month>
                    <volume>84</volume>
                    <issue>1</issue>
                    <fpage>43</fpage>
                    <lpage>9</lpage>
                    <pub-id pub-id-type="medline">8279610</pub-id>
                    <pub-id pub-id-type="pmcid">PMC1614921</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref24">
                <label>24</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Campbell</surname>
                            <given-names>MK</given-names>
                        </name>
                        <name name-style="western">
                            <surname>DeVellis</surname>
                            <given-names>BM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Strecher</surname>
                            <given-names>VJ</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ammerman</surname>
                            <given-names>AS</given-names>
                        </name>
                        <name name-style="western">
                            <surname>DeVellis</surname>
                            <given-names>RF</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Sandler</surname>
                            <given-names>RS</given-names>
                        </name>
                    </person-group>
                    <article-title>Improving dietary behavior: the effectiveness of tailored messages in primary care settings</article-title>
                    <source>Am J Public Health</source>
                    <year>1994</year>
                    <month>05</month>
                    <volume>84</volume>
                    <issue>5</issue>
                    <fpage>783</fpage>
                    <lpage>7</lpage>
                    <pub-id pub-id-type="medline">8179049</pub-id>
                    <pub-id pub-id-type="pmcid">PMC1615043</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref25">
                <label>25</label>
                <nlm-citation citation-type="book">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Petty</surname>
                            <given-names>RE</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Cacioppo</surname>
                            <given-names>JT</given-names>
                        </name>
                    </person-group>
                    <person-group person-group-type="editor">
                        <name name-style="western">
                            <surname>Berkowitz</surname>
                            <given-names>L</given-names>
                        </name>
                    </person-group>
                    <article-title>The Elaboration Likelihood Model of Persuasion</article-title>
                    <source>Advances in experimental social psychology</source>
                    <year>1986</year>
                    <publisher-loc>New York</publisher-loc>
                    <publisher-name>Academic Press</publisher-name>
                </nlm-citation>
            </ref>
            <ref id="ref26">
                <label>26</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Kreuter</surname>
                            <given-names>MW</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bull</surname>
                            <given-names>FC</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Clark</surname>
                            <given-names>EM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Oswald</surname>
                            <given-names>DL</given-names>
                        </name>
                    </person-group>
                    <article-title>Understanding how people process health information: a comparison of tailored and nontailored weight-loss materials</article-title>
                    <source>Health Psychol</source>
                    <year>1999</year>
                    <month>09</month>
                    <volume>18</volume>
                    <issue>5</issue>
                    <fpage>487</fpage>
                    <lpage>94</lpage>
                    <pub-id pub-id-type="medline">10519465</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref27">
                <label>27</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Cacioppo</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Petty</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Feinstein</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Jarvis</surname>
                            <given-names>WBG</given-names>
                        </name>
                    </person-group>
                    <article-title>Dispositional differences in cognitive motivation: The life and times of individuals varying in need for cognition</article-title>
                    <source>Psychological Bulletin</source>
                    <year>1996</year>
                    <volume>119</volume>
                    <issue>2</issue>
                    <fpage>197</fpage>
                    <lpage>253</lpage>
                </nlm-citation>
            </ref>
            <ref id="ref28">
                <label>28</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Crutzen</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Nooijer</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Brouwer</surname>
                            <given-names>W</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Oenema</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Brug</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>NK</given-names>
                        </name>
                    </person-group>
                    <article-title>A conceptual framework for understanding and improving adolescents' exposure to Internet-delivered interventions</article-title>
                    <source>Health Promot Int</source>
                    <year>2009</year>
                    <month>09</month>
                    <volume>24</volume>
                    <issue>3</issue>
                    <fpage>277</fpage>
                    <lpage>84</lpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://heapro.oxfordjournals.org/cgi/pmidlookup?view=long&#38;pmid=19515716" />
                    </comment>
                    <pub-id pub-id-type="doi">10.1093/heapro/dap018</pub-id>
                    <pub-id pub-id-type="medline">19515716</pub-id>
                    <pub-id pub-id-type="pii">dap018</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref29">
                <label>29</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Cyr</surname>
                            <given-names>D</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Head</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ivanov</surname>
                            <given-names>A</given-names>
                        </name>
                    </person-group>
                    <article-title>Perceived interactivity leading to e-loyalty: Development of a model for cognitive-affective user responses</article-title>
                    <source>International Journal of Human-computer studies</source>
                    <year>2009</year>
                    <volume>67</volume>
                    <issue>10</issue>
                    <fpage>850</fpage>
                    <lpage>869</lpage>
                </nlm-citation>
            </ref>
            <ref id="ref30">
                <label>30</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Crutzen</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Cyr</surname>
                            <given-names>D</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>NK</given-names>
                        </name>
                    </person-group>
                    <article-title>Bringing loyalty to e-Health: theory validation using three internet-delivered interventions</article-title>
                    <source>J Med Internet Res</source>
                    <year>2011</year>
                    <volume>13</volume>
                    <issue>3</issue>
                    <fpage>e73</fpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2011/3/e73/" />
                    </comment>
                    <pub-id pub-id-type="doi">10.2196/jmir.1837</pub-id>
                    <pub-id pub-id-type="medline">21946128</pub-id>
                    <pub-id pub-id-type="pii">v13i3e73</pub-id>
                    <pub-id pub-id-type="pmcid">PMC3222180</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref31">
                <label>31</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Strecher</surname>
                            <given-names>VJ</given-names>
                        </name>
                        <name name-style="western">
                            <surname>McClure</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Alexander</surname>
                            <given-names>G</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Chakraborty</surname>
                            <given-names>B</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Nair</surname>
                            <given-names>V</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Konkel</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Greene</surname>
                            <given-names>S</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Couper</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Carlier</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Wiese</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Little</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Pomerleau</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Pomerleau</surname>
                            <given-names>O</given-names>
                        </name>
                    </person-group>
                    <article-title>The role of engagement in a tailored web-based smoking cessation program: randomized controlled trial</article-title>
                    <source>J Med Internet Res</source>
                    <year>2008</year>
                    <volume>10</volume>
                    <issue>5</issue>
                    <fpage>e36</fpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2008/5/e36/" />
                    </comment>
                    <pub-id pub-id-type="doi">10.2196/jmir.1002</pub-id>
                    <pub-id pub-id-type="medline">18984557</pub-id>
                    <pub-id pub-id-type="pii">v10i5e36</pub-id>
                    <pub-id pub-id-type="pmcid">PMC2630833</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref32">
                <label>32</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Verheijden</surname>
                            <given-names>MW</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Jans</surname>
                            <given-names>MP</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Hildebrandt</surname>
                            <given-names>VH</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Hopman-Rock</surname>
                            <given-names>M</given-names>
                        </name>
                    </person-group>
                    <article-title>Rates and determinants of repeated participation in a web-based behavior change program for healthy body weight and healthy lifestyle</article-title>
                    <source>J Med Internet Res</source>
                    <year>2007</year>
                    <volume>9</volume>
                    <issue>1</issue>
                    <fpage>e1</fpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2007/1/e1/" />
                    </comment>
                    <pub-id pub-id-type="doi">10.2196/jmir.9.1.e1</pub-id>
                    <pub-id pub-id-type="medline">17478410</pub-id>
                    <pub-id pub-id-type="pii">v9i1e1</pub-id>
                    <pub-id pub-id-type="pmcid">PMC1794672</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref33">
                <label>33</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Crutzen</surname>
                            <given-names>R</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Nooijer</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Brouwer</surname>
                            <given-names>W</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Oenema</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Brug</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>N</given-names>
                        </name>
                    </person-group>
                    <article-title>Effectiveness of online word of mouth on exposure to an Internet-delivered intervention</article-title>
                    <source>Psychol Health</source>
                    <year>2009</year>
                    <month>07</month>
                    <volume>24</volume>
                    <issue>6</issue>
                    <fpage>651</fpage>
                    <lpage>61</lpage>
                    <pub-id pub-id-type="doi">10.1080/08870440802521094</pub-id>
                    <pub-id pub-id-type="medline">20205018</pub-id>
                    <pub-id pub-id-type="pii">905685535</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref34">
                <label>34</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Glasgow</surname>
                            <given-names>RE</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Vogt</surname>
                            <given-names>TM</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Boles</surname>
                            <given-names>SM</given-names>
                        </name>
                    </person-group>
                    <article-title>Evaluating the public health impact of health promotion interventions: the RE-AIM framework</article-title>
                    <source>Am J Public Health</source>
                    <year>1999</year>
                    <month>09</month>
                    <volume>89</volume>
                    <issue>9</issue>
                    <fpage>1322</fpage>
                    <lpage>7</lpage>
                    <pub-id pub-id-type="medline">10474547</pub-id>
                    <pub-id pub-id-type="pmcid">PMC1508772</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref35">
                <label>35</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Stanczyk</surname>
                            <given-names>NE</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bolman</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Muris</surname>
                            <given-names>JW</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>H</given-names>
                        </name>
                    </person-group>
                    <article-title>Study protocol of a Dutch smoking cessation e-health program</article-title>
                    <source>BMC Public Health</source>
                    <year>2011</year>
                    <volume>11</volume>
                    <fpage>847</fpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.biomedcentral.com/1471-2458/11/847" />
                    </comment>
                    <pub-id pub-id-type="doi">10.1186/1471-2458-11-847</pub-id>
                    <pub-id pub-id-type="medline">22059446</pub-id>
                    <pub-id pub-id-type="pii">1471-2458-11-847</pub-id>
                    <pub-id pub-id-type="pmcid">PMC3220643</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref36">
                <label>36</label>
                <nlm-citation citation-type="web">
                    <person-group person-group-type="author">
                        <collab>Flycatcher Internet Research</collab>
                    </person-group>
                    <source>Het onderzoeksbureau voor online onderzoek</source>
                    <year>2012</year>
                    <access-date>2012-10-22</access-date>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.flycatcher.eu/">http://www.flycatcher.eu/</ext-link>
                    </comment>
                    <pub-id pub-id-type="other">6BbZFzK72</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref37">
                <label>37</label>
                <nlm-citation citation-type="web">
                    <person-group person-group-type="author">
                        <collab>CBS</collab>
                    </person-group>
                    <source>Centraal Bureau voor de Statistiek</source>
                    <year>2012</year>
                    <access-date>2012-04-26</access-date>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.cbs.nl/nl-NL/menu/home/default.htm">http://www.cbs.nl/nl-NL/menu/home/default.htm</ext-link>
                    </comment>
                    <pub-id pub-id-type="other">67D55bpsp</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref38">
                <label>38</label>
                <nlm-citation citation-type="web">
                    <source>Steunbijstoppen.nl</source>
                    <year>2012</year>
                    <access-date>2012-10-22</access-date>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.steunbijstoppen.nl/">http://www.steunbijstoppen.nl/</ext-link>
                    </comment>
                    <pub-id pub-id-type="other">6BbakEW1j</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref39">
                <label>39</label>
                <nlm-citation citation-type="web">
                    <person-group person-group-type="author">
                        <collab>OSE</collab>
                    </person-group>
                    <source>OverNite Software Europe BV</source>
                    <year>2012</year>
                    <access-date>2012-04-26</access-date>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.ose.nl/home">http://www.ose.nl/home</ext-link>
                    </comment>
                    <pub-id pub-id-type="other">67D59McaM</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref40">
                <label>40</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Mudde</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Leijs</surname>
                            <given-names>I</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Charlton</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Vartiainen</surname>
                            <given-names>E</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Buijs</surname>
                            <given-names>G</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Clemente</surname>
                            <given-names>MP</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Storm</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Gonz&#225;lez Navarro</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Nebot</surname>
                            <given-names>M</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Prins</surname>
                            <given-names>T</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kremers</surname>
                            <given-names>S</given-names>
                        </name>
                    </person-group>
                    <article-title>The European Smoking Prevention Framework Approach (EFSA): an example of integral prevention</article-title>
                    <source>Health Educ Res</source>
                    <year>2003</year>
                    <month>10</month>
                    <volume>18</volume>
                    <issue>5</issue>
                    <fpage>611</fpage>
                    <lpage>26</lpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://her.oxfordjournals.org/cgi/pmidlookup?view=long&#38;pmid=14572020" />
                    </comment>
                    <pub-id pub-id-type="medline">14572020</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref41">
                <label>41</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Heatherton</surname>
                            <given-names>TF</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kozlowski</surname>
                            <given-names>LT</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Frecker</surname>
                            <given-names>RC</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Fagerstr&#246;m</surname>
                            <given-names>KO</given-names>
                        </name>
                    </person-group>
                    <article-title>The Fagerstr&#246;m Test for Nicotine Dependence: a revision of the Fagerstr&#246;m Tolerance Questionnaire</article-title>
                    <source>Br J Addict</source>
                    <year>1991</year>
                    <month>09</month>
                    <volume>86</volume>
                    <issue>9</issue>
                    <fpage>1119</fpage>
                    <lpage>27</lpage>
                    <pub-id pub-id-type="medline">1932883</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref42">
                <label>42</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kremers</surname>
                            <given-names>SP</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Smeets</surname>
                            <given-names>T</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Brug</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Eijmael</surname>
                            <given-names>K</given-names>
                        </name>
                    </person-group>
                    <article-title>The effectiveness of tailored feedback and action plans in an intervention addressing multiple health behaviors</article-title>
                    <source>Am J Health Promot</source>
                    <year>2008</year>
                    <volume>22</volume>
                    <issue>6</issue>
                    <fpage>417</fpage>
                    <lpage>25</lpage>
                    <pub-id pub-id-type="doi">10.4278/ajhp.22.6.417</pub-id>
                    <pub-id pub-id-type="medline">18677882</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref43">
                <label>43</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Dijkstra</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>H</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bakker</surname>
                            <given-names>M</given-names>
                        </name>
                    </person-group>
                    <article-title>Pros and cons of quitting, self-efficacy, and the stages of change in smoking cessation</article-title>
                    <source>J Consult Clin Psychol</source>
                    <year>1996</year>
                    <month>08</month>
                    <volume>64</volume>
                    <issue>4</issue>
                    <fpage>758</fpage>
                    <lpage>63</lpage>
                    <pub-id pub-id-type="medline">8803366</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref44">
                <label>44</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Cacioppo</surname>
                            <given-names>JT</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Petty</surname>
                            <given-names>RE</given-names>
                        </name>
                    </person-group>
                    <article-title>The need for cognition</article-title>
                    <source>Journal of Personality and Social Psychology</source>
                    <year>1982</year>
                    <volume>42</volume>
                    <issue>1</issue>
                    <fpage>116</fpage>
                    <lpage>131</lpage>
                </nlm-citation>
            </ref>
            <ref id="ref45">
                <label>45</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Cyr</surname>
                            <given-names>D</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bonanni</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Bowes</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Ilsever</surname>
                            <given-names>J</given-names>
                        </name>
                    </person-group>
                    <article-title>Beyond Trust: Website Design Preferences across cultures</article-title>
                    <source>Journal of Global Information Management</source>
                    <year>2005</year>
                    <volume>13</volume>
                    <fpage>24</fpage>
                    <lpage>52</lpage>
                </nlm-citation>
            </ref>
            <ref id="ref46">
                <label>46</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Vandelanotte</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Duncan</surname>
                            <given-names>MJ</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Plotnikoff</surname>
                            <given-names>RC</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Mummery</surname>
                            <given-names>WK</given-names>
                        </name>
                    </person-group>
                    <article-title>Do participants' preferences for mode of delivery (text, video, or both) influence the effectiveness of a Web-based physical activity intervention?</article-title>
                    <source>J Med Internet Res</source>
                    <year>2012</year>
                    <volume>14</volume>
                    <issue>1</issue>
                    <fpage>e37</fpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2012/1/e37/" />
                    </comment>
                    <pub-id pub-id-type="doi">10.2196/jmir.1998</pub-id>
                    <pub-id pub-id-type="medline">22377834</pub-id>
                    <pub-id pub-id-type="pii">v14i1e37</pub-id>
                    <pub-id pub-id-type="pmcid">PMC3374539</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref47">
                <label>47</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Schneider</surname>
                            <given-names>F</given-names>
                        </name>
                        <name name-style="western">
                            <surname>van Osch</surname>
                            <given-names>L</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Schulz</surname>
                            <given-names>DN</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kremers</surname>
                            <given-names>SP</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>H</given-names>
                        </name>
                    </person-group>
                    <article-title>The influence of user characteristics and a periodic email prompt on exposure to an internet-delivered computer-tailored lifestyle program</article-title>
                    <source>J Med Internet Res</source>
                    <year>2012</year>
                    <volume>14</volume>
                    <issue>2</issue>
                    <fpage>e40</fpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2012/2/e40/" />
                    </comment>
                    <pub-id pub-id-type="doi">10.2196/jmir.1939</pub-id>
                    <pub-id pub-id-type="medline">22382037</pub-id>
                    <pub-id pub-id-type="pii">v14i2e40</pub-id>
                    <pub-id pub-id-type="pmcid">PMC3376522</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref48">
                <label>48</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Brug</surname>
                            <given-names>J</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Oenema</surname>
                            <given-names>A</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Campbell</surname>
                            <given-names>M</given-names>
                        </name>
                    </person-group>
                    <article-title>Past, present, and future of computer-tailored nutrition education</article-title>
                    <source>Am J Clin Nutr</source>
                    <year>2003</year>
                    <month>04</month>
                    <volume>77</volume>
                    <issue>4 Suppl</issue>
                    <fpage>1028S</fpage>
                    <lpage>1034S</lpage>
                    <comment>
                        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.ajcn.org/cgi/pmidlookup?view=long&#38;pmid=12663313" />
                    </comment>
                    <pub-id pub-id-type="medline">12663313</pub-id>
                </nlm-citation>
            </ref>
            <ref id="ref49">
                <label>49</label>
                <nlm-citation citation-type="journal">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Smit</surname>
                            <given-names>ES</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Hoving</surname>
                            <given-names>C</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Cox</surname>
                            <given-names>VC</given-names>
                        </name>
                        <name name-style="western">
                            <surname>de Vries</surname>
                            <given-names>H</given-names>
                        </name>
                    </person-group>
                    <article-title>Influence of recruitment strategy on the reach and effect of a web-based multiple tailored smoking cessation intervention among Dutch adult smokers</article-title>
                    <source>Health Educ Res</source>
                    <year>2012</year>
                    <month>04</month>
                    <volume>27</volume>
                    <issue>2</issue>
                    <fpage>191</fpage>
                    <lpage>9</lpage>
                    <pub-id pub-id-type="doi">10.1093/her/cyr099</pub-id>
                    <pub-id pub-id-type="medline">22058288</pub-id>
                    <pub-id pub-id-type="pii">cyr099</pub-id>
                </nlm-citation>
            </ref>
        </ref-list>
    </back>
</article>
