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    <front>
        <journal-meta>
            <journal-id journal-id-type="publisher-id">JMIR</journal-id>
            <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
            <journal-title>Journal of Medical Internet Research</journal-title>
            <issn pub-type="epub">1438-8871</issn>
            <publisher>
                <publisher-name>Gunther Eysenbach</publisher-name>
                <publisher-loc>Centre for Global eHealth Innovation, Toronto, Canada</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="publisher-id">v7i4e39</article-id>
            <article-id pub-id-type="pmid">16236691</article-id>
            <article-id pub-id-type="doi">10.2196/jmir.7.4.e39</article-id>
            <article-categories>
                <subj-group subj-group-type="article-type">
                    <subject>Letter</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>"Is Cybermedicine Killing You?" - Peer Review and Evidence-Based Medicine: Author's Reply</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" id="contrib1" corresp="yes">
                    <name name-style="western">
                        <surname>Eysenbach</surname>
                        <given-names>Gunther</given-names>
                    </name>
                    <degrees>MD, MPH</degrees>
                    <address>
                        <institution>Centre for Global eHealth Innovation</institution>
                        <institution>University of Toronto and University Health Network</institution>
                        <addr-line>190 Elizabeth Street</addr-line>
                        <addr-line>Toronto, ON M5G 2C4</addr-line>
                        <country>Canada</country>
                        <phone>+1 416 340 4800 ext 6427</phone>
                        <fax>+1 416 340 3595</fax>
                        <email>geysenba@uhnres.utoronto.ca</email>
                    </address>
                </contrib>
            </contrib-group>
            <pub-date pub-type="collection">
                <season>Jul-Sep</season>
                <year>2005</year>
            </pub-date>
            <pub-date pub-type="epub">
                <day>28</day>
                <month>7</month>
                <year>2005</year>
            </pub-date>
            <volume>7</volume>
            <issue>4</issue>
            <elocation-id>e39</elocation-id>
            <history>
                <date date-type="received">
                  <day>18</day>
                  <month>07</month>
                  <year>2005</year>
                </date>
                <date date-type="rev-request">
                  <day>18</day>
                  <month>07</month>
                  <year>2005</year>
                </date>
                <date date-type="rev-recd">
                  <day>18</day>
                  <month>07</month>
                  <year>2005</year>
                </date>
                <date date-type="accepted">
                  <day>18</day>
                  <month>07</month>
                  <year>2005</year>
                </date>
            </history>
            <copyright-statement>© Gunther Eysenbach.  Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 28.7.2005.  Except where otherwise noted, articles published in the Journal of Medical Internet Research are distributed under the terms of the Creative Commons Attribution License (http://www.creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, including full bibliographic	details and the URL (see "please cite as" above), and this statement is included.</copyright-statement>
            <copyright-year>2005</copyright-year>
            <self-uri xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2005/4/e39/"/>
            <related-article related-article-type="commentary-article" vol="7" page="e21" xlink:href="http://www.jmir.org/2005/2/e21/" xlink:type="simple">
                <person-group person-group-type="author">
                    <name>
                        <surname>Eysenbach</surname>
                        <given-names>Gunther</given-names>
                    </name>
                    <name>
                        <surname>Kummervold</surname>
                        <given-names>Per Egil</given-names>
                    </name>
                </person-group>
                <article-title>"Is Cybermedicine Killing You?" - The Story of a Cochrane Disaster</article-title>
                <source>J Med Internet Res</source>
                <year>2005</year>
                <volume>7</volume>
                <issue>2</issue>
                <fpage>e21</fpage>
            </related-article>                                    
            <related-article related-article-type="commentary-article" vol="7" page="e38" xlink:href="http://www.jmir.org/2005/2/e38/" xlink:type="simple">
                <person-group person-group-type="author">
                    <name name-style="western">
                        <surname>Fogel</surname>
                        <given-names>Joshua</given-names>
                    </name>
                </person-group>
                <article-title>"Is Cybermedicine Killing You?" - Peer Review and Evidence-Based Medicine</article-title>
                <source>J Med Internet Res</source>
                <year>2005</year>
                <volume>7</volume>
                <issue>2</issue>
                <fpage>e38</fpage>
            </related-article>                 
        </article-meta>
    </front>
    <body>
        <sec>
            <title>Author's Response</title>
            <p>Fogel's suggestion of a grading system according to the level of peer review (reminiscent of grading systems for "level of evidence" of primary studies) is interesting, but further study is required to determine to what degree the proposed ratings actually correlate with quality or peer review rigor. My suggestion [<xref ref-type="bibr" rid="ref1">1</xref>] was to routinely invite all authors of the primary studies to comment on a draft of the systematic review. They actually do not have to peer review the entire paper in the sense of having to write a full referee report, they just should have access to the review before its actual publication to ensure that the authors did not make any major extraction errors (such as in the reported case) or misinterpret any of the original studies (as this would be most easily spotted by the authors of the primary studies). Because authors of systematic reviews often contact the authors of the primary studies anyway (to inquire about nonpublished data or ask other questions), this could be done relatively easily and routinely, in particular, if preprint servers are used, which in other disciplines are common but are underused in medicine.</p>
        </sec>
    </body>
    <back>
        <ref-list>
            <ref id="ref1">
                <label>1</label>
                <nlm-citation citation-type="journal" xlink:type="simple">
                    <person-group person-group-type="author">
                        <name name-style="western">
                            <surname>Eysenbach</surname>
                            <given-names>Gunther</given-names>
                        </name>
                        <name name-style="western">
                            <surname>Kummervold</surname>
                            <given-names>Per Egil</given-names>
                        </name>
                    </person-group>
                    <article-title>"Is cybermedicine killing you?" - the story of a Cochrane disaster</article-title>
                    <source>J Med Internet Res</source>
                    <year>2005</year>
                    <month>6</month>
                    <day>30</day>
                    <volume>7</volume>
                    <issue>2</issue>
                    <fpage>e21</fpage>
                    <comment><ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jmir.org/2005/2/e21/" ext-link-type="uri">http://www.jmir.org/2005/2/e21/</ext-link></comment>
                    <pub-id pub-id-type="medline">15998612</pub-id>
                    <pub-id pub-id-type="pii">v7i2e21</pub-id>
                    <pub-id pub-id-type="doi">10.2196/jmir.7.2.e21</pub-id>
                    </nlm-citation>
            </ref>
        </ref-list>
    </back>
</article>
